Professor Karen Blyth

  • Professor (Beatson Institute for Cancer Research)
  • Honorary Senior Lecturer (School of Veterinary Medicine)

telephone: 01413303686
email: Karen.Blyth@glasgow.ac.uk

Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Henry Wellcome ICM, Bearsden, Glasgow, G61 1BD

ORCID iDhttps://orcid.org/0000-0002-9304-439X

Publications

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Number of items: 111.

2021

McGarry, D. J., Armstrong, G., Castino, G., Mason, S., Clark, W., Shaw, R., McGarry, L., Blyth, K. and Olson, M. F. (2021) MICAL1 regulates actin cytoskeleton organization, directional cell migration and the growth of human breast cancer cells as orthotopic xenograft tumours. Cancer Letters, 519, pp. 226-236. (doi: 10.1016/j.canlet.2021.07.039) (PMID:34314753)

Campbell, K. J. et al. (2021) Breast cancer dependence on MCL-1 is due to its canonical anti-apoptotic function. Cell Death and Differentiation, 28(9), pp. 2589-2600. (doi: 10.1038/s41418-021-00773-4) (PMID:33785871) (PMCID:PMC8408186)

Newman, A. C., Falcone, M. , Huerta Uribe, A. , Zhang, T., Athineos, D., Pietzke, M., Vazquez, A. , Blyth, K. and Maddocks, O. D. K. (2021) Immune regulated IDO1-dependent tryptophan metabolism is source of one-carbon units for pancreatic cancer and stellate cells. Molecular Cell, 81(11), 2290-2302.e7. (doi: 10.1016/j.molcel.2021.03.019) (PMID:33831358)

Nacke, M. et al. (2021) An ARF GTPase module promoting invasion and metastasis through regulating phosphoinositide metabolism. Nature Communications, 12, 1623. (doi: 10.1038/s41467-021-21847-4) (PMID:33712589) (PMCID:PMC7955138)

Tajan, M. et al. (2021) Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy. Nature Communications, 12, 366. (doi: 10.1038/s41467-020-20223-y) (PMID:33446657) (PMCID:PMC7809039)

Latif, A.-L. et al. (2021) BRD4-mediated repression of p53 is a target for combination therapy in AML. Nature Communications, 12(1), 241. (doi: 10.1038/s41467-020-20378-8) (PMID:33431824) (PMCID:PMC7801601)

2020

Mevel, R. et al. (2020) RUNX1 marks a luminal castration-resistant lineage established at the onset of prostate development. eLife, 9, e60225. (doi: 10.7554/elife.60225) (PMID:33025905) (PMCID:PMC7644213)

Zhang, T., Bauer, C., Newman, A. C., Uribe, A. H., Athineos, D., Blyth, K. and Maddocks, O. D.K. (2020) Polyamine pathway activity promotes cysteine essentiality in cancer cells. Nature Metabolism, 2, pp. 1062-1076. (doi: 10.1038/s42255-020-0253-2) (PMID:32747794)

Millar, R., Kilbey, A., Remak, S.-J., Severson, T. M., Dhayade, S., Sandilands, E., Foster, K., Bryant, D. M. , Blyth, K. and Coffelt, S. B. (2020) The MSP-RON axis stimulates cancer cell growth in models of triple negative breast cancer. Molecular Oncology, 14(8), pp. 1868-1880. (doi: 10.1002/1878-0261.12734) (PMID:32484599) (PMCID:PMC7400785)

Dhayade, S., Pietzke, M., Wiesheu, R., Tait-Mulder, J., Athineos, D., Sumpton, D., Coffelt, S. , Blyth, K. and Vazquez, A. (2020) Impact of formate supplementation on body weight and plasma amino acids. Nutrients, 12(8), 2181. (doi: 10.3390/nu12082181) (PMID:32708052) (PMCID:PMC7469024)

Rooney, N. et al. (2020) RUNX1 is a driver of renal cell carcinoma correlating with clinical outcome. Cancer Research, 80(11), pp. 2325-2339. (doi: 10.1158/0008-5472.CAN-19-3870) (PMID:32156779)

Oizel, K. et al. (2020) Formate induces a metabolic switch in nucleotide and energy metabolism. Cell Death and Disease, 11(5), 310. (doi: 10.1038/s41419-020-2523-z) (PMID:32366892) (PMCID:PMC7198490)

Campbell, K. J. and Blyth, K. (2020) Somatic base editing to model oncogenic drivers in breast cancer. Lab Animal, 49, pp. 115-116. (doi: 10.1038/s41684-020-0510-8) (PMID:32152514)

Lie-A-Ling, M., Mevel, R., Patel, R., Blyth, K. , Baena, E., Kouskoff, V. and Lacaud, G. (2020) RUNX1 dosage in development and cancer. Molecules and Cells, 43(2), pp. 126-138. (doi: 10.14348/molcells.2019.0301) (PMID:31991535) (PMCID:PMC7057845)

Sweeney, K., Cameron, E. R. and Blyth, K. (2020) Complex interplay between the RUNX transcription factors and Wnt/β-catenin pathway in cancer: a tango in the night. Molecules and Cells, 43(2), pp. 188-197. (doi: 10.14348/molcells.2019.0310) (PMID:32041394) (PMCID:PMC7057843)

MacKenzie, D. J. et al. (2020) DNMT3B Oncogenic Activity in Human Intestinal Cancer Is Not Linked to CIMP or BRAFV600E Mutation. iScience, 23(2), 100838. (doi: 10.1016/j.isci.2020.100838) (PMID:32058953) (PMCID:PMC7000804)

Cheung, E. C., DeNicola, G. M., Nixon, C., Blyth, K. , Labuschagne, C. F., Tuveson, D. A. and Vousden, K. (2020) Dynamic ROS control by TIGAR regulates the initiation and progression of pancreatic cancer. Cancer Cell, 37(2), 168-182.e4. (doi: 10.1016/j.ccell.2019.12.012) (PMID:31983610) (PMCID:PMC7008247)

Caraffini, V. et al. (2020) Loss of RAF kinase inhibitor protein is involved in myelomonocytic differentiation and aggravates RAS-driven myeloid leukemogenesis. Haematologica, 105(2), pp. 375-386. (doi: 10.3324/haematol.2018.209650) (PMID:31097632) (PMCID:PMC7012480)

Blagih, J. et al. (2020) Cancer-specific loss of p53 leads to a modulation of myeloid and T cell responses. Cell Reports, 30(2), 481-496.e6. (doi: 10.1016/j.celrep.2019.12.028) (PMID:31940491) (PMCID:31940491)

Loveridge, C. J. et al. (2020) BRF1 accelerates prostate tumourigenesis and perturbs immune infiltration. Oncogene, 39, pp. 1797-1806. (doi: 10.1038/s41388-019-1106-x) (PMID:31740786) (PMCID:PMC7033044)

Ran, R. et al. (2020) A role for CBFβ in maintaining the metastatic phenotype of breast cancer cells. Oncogene, 39, pp. 2624-2637. (doi: 10.1038/s41388-020-1170-2) (PMID:32005976) (PMCID:PMC7082223)

2019

Liko, D. et al. (2019) Brf1 loss and not overexpression disrupts tissues homeostasis in the intestine, liver and pancreas. Cell Death and Differentiation, 26(12), pp. 2535-2550. (doi: 10.1038/s41418-019-0316-7) (PMID:30858608) (PMCID:PMC6861133)

Johnson, S. A., Ormsby, M. J., McIntosh, A., Tait, S. W.G. , Blyth, K. and Wall, D. M. (2019) Increasing the bactofection capacity of a mammalian expression vector by removal of the f1 ori. Cancer Gene Therapy, 26(7-8), pp. 183-194. (doi: 10.1038/s41417-018-0039-9) (PMID:30100607) (PMCID:PMC6760541)

Rudzka, D. A. et al. (2019) Migration through physical constraints is enabled by MAPK-induced cell softening via actin cytoskeleton re-organization. Journal of Cell Science, 132(11), jcs224071. (doi: 10.1242/jcs.224071) (PMID:31152052) (PMCID:PMC6589089)

Vande Voorde, J., Ackermann, T., Pfetzer, N., Sumpton, D., Mackay, G., Kalna, G., Nixon, C., Blyth, K. , Gottlieb, E. and Tardito, S. (2019) Improving the metabolic fidelity of cancer models with a physiological cell culture medium. Science Advances, 5(1), eaau7314. (doi: 10.1126/sciadv.aau7314) (PMID:30613774) (PMCID:PMC6314821)

Hassan, S. et al. (2019) A unique panel of patient-derived cutaneous squamous cell carcinoma cell lines provides a preclinical pathway for therapeutic testing. International Journal of Molecular Sciences, 20(14), 3428. (doi: 10.3390/ijms20143428) (PMID:31336867) (PMCID:PMC6678499)

2018

Novo, D. et al. (2018) Mutant p53s generate pro-invasive niches by influencing exosome podocalyxin levels. Nature Communications, 9, 5069. (doi: 10.1038/s41467-018-07339-y) (PMID:30498210) (PMCID:PMC6265295)

Meiser, J. et al. (2018) Increased formate overflow is a hallmark of oxidative cancer. Nature Communications, 9, 1368. (doi: 10.1038/s41467-018-03777-w) (PMID:29636461) (PMCID:PMC5893600)

Campbell, K. J. et al. (2018) MCL-1 is a prognostic indicator and drug target in breast cancer. Cell Death and Disease, 9, 19. (doi: 10.1038/s41419-017-0035-2) (PMID:29339815) (PMCID:PMC5833338)

McCarroll, C. S. et al. (2018) Runx1 deficiency protects against adverse cardiac remodeling after myocardial infarction. Circulation, 137(1), pp. 57-70. (doi: 10.1161/CIRCULATIONAHA.117.028911) (PMID:29030345) (PMCID:PMC5757664)

2017

Dornier, E. et al. (2017) Glutaminolysis drives membrane trafficking to promote invasiveness of breast cancer cells. Nature Communications, 8, 2255. (doi: 10.1038/s41467-017-02101-2) (PMID:29269878) (PMCID:PMC5740148)

Walton, J. B. et al. (2017) CRISPR/Cas9-derived models of ovarian high grade serous carcinoma targeting Brca1, Pten and Nf1, and correlation with platinum sensitivity. Scientific Reports, 7, 16827. (doi: 10.1038/s41598-017-17119-1) (PMID:29203787) (PMCID:PMC5715106)

Loveridge, C. J. et al. (2017) Analysis of Nkx3.1:Cre-driven Erk5 deletion reveals a profound spinal deformity which is linked to increased osteoclast activity. Scientific Reports, 7, 13241. (doi: 10.1038/s41598-017-13346-8) (PMID:29038439) (PMCID:PMC5643304)

van Tuyn, J. et al. (2017) Oncogene-expressing senescent melanocytes upregulate MhC class II, a candidate melanoma suppressor function. Journal of Investigative Dermatology, 137(10), pp. 2197-2207. (doi: 10.1016/j.jid.2017.05.030) (PMID:28647344) (PMCID:PMC5613751)

Giampazolias, E. et al. (2017) Mitochondrial permeabilization engages NF-κB-dependent anti-tumour activity under caspase deficiency. Nature Cell Biology, 19(9), pp. 1116-1129. (doi: 10.1038/ncb3596) (PMID:28846096) (PMCID:PMC5624512)

Reid, S. E. et al. (2017) Tumor matrix stiffness promotes metastatic cancer cell interaction with the endothelium. EMBO Journal, 36(16), pp. 2373-2389. (doi: 10.15252/embj.201694912) (PMID:28694244) (PMCID:PMC5556271)

Riggio, A. I. and Blyth, K. (2017) The enigmatic role of RUNX1 in female-related cancers - current knowledge & future perspectives. FEBS Journal, 284(15), pp. 2345-2362. (doi: 10.1111/febs.14059) (PMID:28304148)

Loveridge, C. J. et al. (2017) Increased T cell infiltration elicited by Erk5 deletion in a Pten-deficient mouse model of prostate carcinogenesis. Cancer Research, 77(12), pp. 3158-3168. (doi: 10.1158/0008-5472.CAN-16-2565) (PMID:28515147)

Hock, A. K. et al. (2017) Development of an inducible mouse model of iRFP713 to track recombinase activity and tumour development in vivo. Scientific Reports, 7, 1837. (doi: 10.1038/s41598-017-01741-0) (PMID:28500323) (PMCID:PMC5431786)

Maddocks, O. D.K. et al. (2017) Modulating the therapeutic response of tumours to dietary serine and glycine starvation. Nature, 544(7650), pp. 372-376. (doi: 10.1038/nature22056) (PMID:28425994)

Holen, I., Speirs, V., Morrissey, B. and Blyth, K. (2017) In vivo models in breast cancer research: progress, challenges and future directions. Disease Models and Mechanisms, 10(4), pp. 359-371. (doi: 10.1242/dmm.028274) (PMID:28381598) (PMCID:PMC5399571)

Rooney, N., Riggio, A. I., Mendoza-Villanueva, D., Shore, P., Cameron, E. R. and Blyth, K. (2017) Runx genes in breast cancer and the mammary lineage. In: Groner, Y., Ito, Y., Liu, P., Neil, J. C., Speck, N. A. and van Wijnen, A. (eds.) RUNX Proteins in Development and Cancer. Series: Advances in experimental medicine and biology, 96 (962). Springer, pp. 353-368. ISBN 9789811032318 (doi:10.1007/978-981-10-3233-2_22)

Hernandez-Fernaud, J. R. et al. (2017) Secreted CLIC3 drives cancer progression through its glutathione-dependent oxidoreductase activity. Nature Communications, 8, 14206. (doi: 10.1038/ncomms14206) (PMID:28198360) (PMCID:PMC5316871)

Bulusu, V. et al. (2017) Acetate recapturing by nuclear acetyl-CoA synthetase 2 prevents loss of histone acetylation during oxygen and serum limitation. Cell Reports, 18(3), pp. 647-658. (doi: 10.1016/j.celrep.2016.12.055) (PMID:28099844) (PMCID:PMC5276806)

Morrissey, B., Blyth, K. , Carter, P., Chelala, C., Jones, L., Holen, I. and Speirs, V. (2017) The sharing experimental animal resources, coordinating holdings (SEARCH) framework: encouraging reduction, replacement, and refinement in animal research. PLoS Biology, 15(1), e2000719. (doi: 10.1371/journal.pbio.2000719) (PMID:28081116) (PMCID:PMC5230739)

Weigert, M. et al. (2017) RIPK3 promotes adenovirus type 5 activity. Cell Death and Disease, 8, 3206. (doi: 10.1038/s41419-017-0110-8) (PMID:29238045) (PMCID:PMC5870599)

2016

Meiser, J. et al. (2016) Serine one-carbon catabolism with formate overflow. Science Advances, 2(10), e1601273. (doi: 10.1126/sciadv.1601273) (PMID:27819051) (PMCID:PMC5091358)

Woodward, J. et al. (2016) Condensin II mutation causes T-cell lymphoma through tissue-specific genome instability. Genes and Development, 30(19), pp. 2173-2186. (doi: 10.1101/gad.284562.116) (PMID:27737961)

Birch, J. et al. (2016) The initiator methionine tRNA drives cell migration and invasion leading to increased metastatic potential in melanoma. Biology Open, 5(10), pp. 1371-1379. (doi: 10.1242/bio.019075) (PMID:27543055) (PMCID:PMC5087684)

Walton, J. et al. (2016) CRISPR/Cas9-mediated Trp53 and Brca2 knockout to generate improved murine models of ovarian high grade serous carcinoma. Cancer Research, 76(20), pp. 6118-6129. (doi: 10.1158/0008-5472.CAN-16-1272) (PMID:27530326) (PMCID:PMC5802386)

Speirs, V., Morrisey, B., Holen, I., Blyth, K. , Carter, P., Chelala, C. and Jones, L. (2016) SEARCHBreast: an online resource designed to increase the efficiency of using materials derived from breast cancer studies in animals. Journal of Pathology, 240(1), p. 120. (doi: 10.1002/path.4755) (PMID:27265197)

Carter, P., Blyth, K. , Holen, I., Jones, L., Morrissey, B., Speirs, V. and Chelala, C. (2016) The SEARCHBreast portal: a virtual bioresource to facilitate the sharing of surplus animal materials derived from breast cancer studies. Open Journal of Bioresources, 3(1), e4. (doi: 10.5334/ojb.21) (PMID:6323741) (PMCID:PMC255634)

Morrissey, B., Holen, I., Chelala, C., Carter, P., Jones, L., Blyth, K. and Speirs, V. (2016) Introducing SEARCHBreast: a virtual resource to facilitate sharing of surplus animal material developed for breast cancer research. npj Breast Cancer, 2, 16020. (doi: 10.1038/npjbcancer.2016.20) (PMID:28721381) (PMCID:PMC5515334)

Patella, F., Neilson, L., Athineos, D., Erami Rud Majani, Z., Anderson, K. I., Blyth, K. , Ryan, K. and Zanivan, S. R. (2016) In-depth proteomics identifies a role for autophagy in controlling reactive oxygen species mediated endothelial permeability. Journal of Proteome Research, 15(7), pp. 2187-2197. (doi: 10.1021/acs.jproteome.6b00166) (PMID:27246970)

Morrissey, B., Blyth, K. , Carter, P., Chelala, C., Jones, L., Holen, I. and Speirs, V. (2016) SEARCHBreast: a new online resource to make surplus material from in vivo models of breast cancer visible and accessible to researchers. Breast Cancer Research, 18, 59. (doi: 10.1186/s13058-016-0716-2) (PMID:27246323) (PMCID:PMC4888409)

Blyth, K. , Carter, P., Morrissey, B., Chelala, C., Jones, L., Holen, I. and Speirs, V. (2016) SEARCHBreast: a new resource to locate and share surplus archival material from breast cancer animal models to help address the 3Rs. Breast Cancer Research and Treatment, 156(3), pp. 447-452. (doi: 10.1007/s10549-016-3785-0) (PMID:27083180)

Clarke, C. J. et al. (2016) The initiator methionine tRNA drives secretion of type II collagen from stromal fibroblasts to promote tumor growth and angiogenesis. Current Biology, 26(6), pp. 755-765. (doi: 10.1016/j.cub.2016.01.045) (PMID:26948875) (PMCID:PMC4819511)

Marusiak, A. A. et al. (2016) Recurrent MLK4 loss-of-function mutations suppress JNK signaling to promote colon tumorigenesis. Cancer Research, 76(3), pp. 724-735. (doi: 10.1158/0008-5472.can-15-0701-t) (PMID:26637668) (PMCID:PMC4740929)

Cheung, E., Lee, P., Ceteci, F., Nixon, C., Blyth, K. , Sansom, O. and Vousden, K. (2016) Opposing effects of TIGAR- and RAC1-derived ROS on Wnt-driven proliferation in the mouse intestine. Genes and Development, 30(1), pp. 52-63. (doi: 10.1101/gad.271130.115) (PMID:26679840) (PMCID:PMC4701978)

2015

Morrissey, B., Blyth, K. , Carter, P., Chelala, C., Holen, I., Jones, L. and Speirs, V. (2015) SEARCHBreast Workshop Proceedings: 3D modelling of breast cancer. Alternatives to Laboratory Animals, 43(6), pp. 367-375. (doi: 10.1177/026119291504300604) (PMID:26753939)

Naseer, A. et al. (2015) Frequent infection of human cancer xenografts with murine endogenous retroviruses in vivo. Viruses, 7(4), pp. 2014-2029. (doi: 10.3390/v7042014) (PMID:25912714) (PMCID:PMC4411688)

Iglesias, J. M. et al. (2015) Annexin A8 identifies a subpopulation of transiently quiescent c-kit positive luminal progenitor cells of the ductal mammary epithelium. PLoS ONE, 10(3), e0119718. (doi: 10.1371/journal.pone.0119718) (PMID:25803307) (PMCID:PMC4372349)

Ichim, G. et al. (2015) Limited mitochondrial permeabilization causes DNA damage and genomic instability in the absence of cell death. Molecular Cell, 57(5), pp. 860-872. (doi: 10.1016/j.molcel.2015.01.018) (PMID:25702873) (PMCID:PMC4352766)

Schug, Z. T. et al. (2015) Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stress. Cancer Cell, 27(1), pp. 57-71. (doi: 10.1016/j.ccell.2014.12.002) (PMID:25584894) (PMCID:PMC4297291)

Cardaci, S. et al. (2015) Pyruvate carboxylation enables growth of SDH-deficient cells by supporting aspartate biosynthesis. Nature Cell Biology, 17, pp. 1317-1326. (doi: 10.1038/ncb3233) (PMID:26302408) (PMCID:PMC4591470)

Dikovskaya, D. et al. (2015) Mitotic stress is an integral part of the oncogene-induced senescence program that promotes multinucleation and cell cycle arrest. Cell Reports, 12(9), pp. 1483-1496. (doi: 10.1016/j.celrep.2015.07.055) (PMID:26299965) (PMCID:PMC4562906)

Ferrari, N. et al. (2015) Runx2 contributes to the regenerative potential of the mammary epithelium. Scientific Reports, 5, 15658. (doi: 10.1038/srep15658) (PMID:26489514) (PMCID:PMC4614940)

Pawlikowski, J.S. et al. (2015) Acute inhibition of MEK suppresses congenital melanocytic nevus syndrome in a murine model driven by activated NRAS and Wnt signaling. Journal of Investigative Dermatology, 135(8), pp. 2093-2101. (doi: 10.1038/jid.2015.114) (PMID:25815427) (PMCID:PMC4539947)

Zheng, L. et al. (2015) Fumarate induces redox-dependent senescence by modifying glutathione metabolism. Nature Communications, 6, 6001. (doi: 10.1038/ncomms7001) (PMID:25613188) (PMCID:PMC4340546)

2014

Ferrari, N., Mohammed, Z. M. A., Nixon, C., Mason, S. M., Mallon, E., McMillan, D. C. , Morris, J. S. , Cameron, E. R. , Edwards, J. and Blyth, K. (2014) Expression of RUNX1 correlates with poor patient prognosis in triple negative breast cancer. PLoS ONE, 9(6), e100759. (doi: 10.1371/journal.pone.0100759) (PMID:24967588) (PMCID:PMC4072705)

Cheung, E., Lee, P., Berkers, C., Blyth, K. , Sansom, O. and Vousden, K. (2014) The in vivo function of TIGAR, a p53 target gene that regulates glucose metabolism. Cancer and Metabolism, 2, P15. (doi: 10.1186/2049-3002-2-S1-P15) (PMCID:PMC4072993)

Li, A. et al. (2014) Fascin is regulated by slug, promotes progression of pancreatic cancer in mice, and is associated with patient outcomes. Gastroenterology, 146(5), 1386-1396.e17. (doi: 10.1053/j.gastro.2014.01.046) (PMID:24462734) (PMCID:PMC4000441)

McDonald, L. et al. (2014) RUNX2 correlates with subtype-specific breast cancer in a human tissue microarray, and ectopic expression of Runx2 perturbs differentiation in the mouse mammary gland. Disease Models and Mechanisms, 7(5), pp. 525-534. (doi: 10.1242/dmm.015040)

Hock, A. K., Lee, P., Maddocks, O. D. , Mason, S. M., Blyth, K. and Vousden, K. H. (2014) iRFP is a sensitive marker for cell number and tumor growth in high-throughput systems. Cell Cycle, 13(2), pp. 220-226. (doi: 10.4161/cc.26985)

Rai, T. S. et al. (2014) HIRA orchestrates a dynamic chromatin landscape in senescence and is required for suppression of neoplasia. Genes and Development, 28(24), pp. 2712-2725. (doi: 10.1101/gad.247528.114) (PMID:25512559) (PMCID:PMC4265675)

2013

Pawlikowski, J.S., McBryan, T., van Tuyn, J., Drotar, M.E., Hewitt, R.N., Maier, A.B., King, A., Blyth, K. , Wu, H. and Adams, P.D. (2013) Wnt signaling potentiates nevogenesis. Proceedings of the National Academy of Sciences of the United States of America, 110(40), pp. 16009-16014. (doi: 10.1073/pnas.1303491110) (PMID:24043806) (PMCID:PMC3791768)

Cheung, E.C., Athineos, D., Lee, P., Ridgway, R.A., Lambie, W., Nixon, C., Strathdee, D., Blyth, K. , Sansom, O.J. and Vousden, K.H. (2013) TIGAR is required for efficient intestinal regeneration and tumorigenesis. Developmental Cell, 25(5), pp. 463-477. (doi: 10.1016/j.devcel.2013.05.001)

Ferrari, N., McDonald, L., Morris, J.S. , Cameron, E.R. and Blyth, K. (2013) RUNX2 in mammary gland development and breast cancer. Journal of Cellular Physiology, 228(6), pp. 1137-1142. (doi: 10.1002/jcp.24285)

Zheng, L., MacKenzie, E. D., Karim, S. A., Hedley, A., Blyth, K. , Kalna, G., Watson, D. G., Szlosarek, P., Frezza, C. and Gottlieb, E. (2013) Reversed argininosuccinate lyase activity in fumarate hydratase-deficient cancer cells. Cancer and Metabolism, 1, 12. (doi: 10.1186/2049-3002-1-12) (PMID:24280230) (PMCID:PMC4108060)

Maddocks, O.D.K. , Berkers, C.R., Mason, S.M., Zheng, L., Blyth, K. , Gottlieb, E. and Vousden, K.H. (2013) Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells. Nature, 493(7433), pp. 542-546. (doi: 10.1038/nature11743)

2012

Yu, X. et al. (2012) N-WASP coordinates the delivery and F-actin-mediated capture of MT1-MMP at invasive pseudopods. Journal of Cell Biology, 199(3), pp. 527-544. (doi: 10.1083/jcb.201203025)

Cheung, E. C., Athineos, D., Ridgway, R., Blyth, K. , Strathdee, D., Sansom, O. and Vousden, K. H. (2012) The in vivo function of the p53 target gene TIGAR. BMC Proceedings, 6, P12. (doi: 10.1186/1753-6561-6-S3-P12) (PMCID:PMC3395062)

Blyth, K. , Morton, J.P. and Sansom, O.J. (2012) The right time, the right place: will targeting human cancer-associated mutations to the mouse provide the perfect preclinical model? Current Opinion in Genetics and Development, 22(1), pp. 28-35. (doi: 10.1016/j.gde.2012.02.009)

Li, A., Ma, Y., Jin, M., Mason, S., Mort, R.L., Blyth, K. , Larue, L., Sansom, O.J. and Machesky, L.M. (2012) Activated mutant NRasQ61K drives aberrant melanocyte signaling, survival, and invasiveness via a rac1-Dependent mechanism. Journal of Investigative Dermatology, 132(11), pp. 2610-2621. (doi: 10.1038/jid.2012.186)

Zebisch, A. et al. (2012) Frequent loss of RAF kinase inhibitor protein expression in acute myeloid leukemia. Leukemia, 26(8), pp. 1842-1849. (doi: 10.1038/leu.2012.61)

2010

Blyth, K. , Vaillant, F., Jenkins, A., McDonald, L., Pringle, M. A. , Huser, C. , Stein, T., Neil, J. and Cameron, E. R. (2010) Runx2 in normal tissues and cancer cells: A developing story. Blood Cells, Molecules, and Diseases, 45(2), pp. 117-123. (doi: 10.1016/j.bcmd.2010.05.007)

Woodcock, S., Rushton, H., Castañeda-Saucedo, E., Myant, K., White, G., Blyth, K. , Sansom, O. and Malliri, A. (2010) Tiam1-Rac Signaling Counteracts Eg5 during Bipolar Spindle Assembly to Facilitate Chromosome Congression. Current Biology, 20(7), pp. 669-675. (doi: 10.1016/j.cub.2010.02.033)

2009

Blyth, K. , Slater, N., Hanlon, L., Bell, M., Mackay, N., Stewart, M., Neil, J.C. and Cameron, E.R. (2009) Runx1 promotes B-cell survival and lymphoma development. Blood Cells, Molecules, and Diseases, 43(1), pp. 12-19. (doi: 10.1016/j.bcmd.2009.01.013)

Scobie, L. et al. (2009) A novel model of SCID-X1 reconstitution reveals predisposition to retrovirus-induced lymphoma but no evidence of gammaC gene oncogenicity. Molecular Therapy, 17(6), pp. 1031-1038. (doi: 10.1038/mt.2009.59)

2007

Stewart, M., Mackay, N., Hanlon, L., Blyth, K. , Scobie, L., Cameron, E. and Neil, J. (2007) Insertional mutagenesis reveals progression genes and checkpoints in MYC/Runx2 lymphomas. Cancer Research, 67(11), pp. 5126-5133. (doi: 10.1158/0008-5472.CAN-07-0433) (PMID:17545590) (PMCID:PMC2562448)

Kilbey, A., Blyth, K. , Wotton, S., Terry, A., Jenkins, A., Bell, M., Hanlon, L., Cameron, E.R. and Neil, J.C. (2007) Runx2 disruption promotes immortalization and confers resistance to oncogene-induced senescence in primary murine fibroblasts. Cancer Research, 67(23), pp. 11263-11271. (doi: 10.1158/0008-5472.CAN-07-3016)

2006

Blyth, K. , Vaillant, F., Hanlon, L., Mackay, N., Bell, M., Jenkins, A., Neil, J.C. and Cameron, E.R. (2006) Runx2 and MYC collaborate in lymphoma development by suppressing apoptotic and growth arrest pathways in vivo. Cancer Research, 66(4), pp. 2195-2201. (doi: 10.1158/0008-5472.CAN-05-3558) (PMID:16489021)

Thrasher, A.J. et al. (2006) Gene therapy: X-SCID transgene leukaemogenicity. Nature, 443(7109), E5-E6. (doi: 10.1038/nature05219)

2005

Blyth, K. , Cameron, E.R. and Neil, J.C. (2005) The RUNX genes: gain or loss of function in cancer. Nature Reviews Cancer, 5(5), pp. 376-387. (doi: 10.1038/nrc1607) (PMID:15864279)

2004

Wotton, S. F., Blyth, K. , Kilbey, A., Jenkins, A., Terry, A., Bernardin-Fried, F., Friedman, A. D., Baxter, E. W., Neil, J. C. and Cameron, E. R. (2004) RUNX1 transformation of primary embryonic fibroblasts is revealed in the absence of p53. Oncogene, 23(32), pp. 5476-5486. (doi: 10.1038/sj.onc.1207729) (PMID:15133495)

2003

Cameron, E. R., Blyth, K. , Hanlon, L., Kilbey, A., Mackay, N., Stewart, M., Terry, A., Vaillant, F., Wotton, S. and Neil, J. C. (2003) The Runx genes as dominant oncogenes. Blood Cells, Molecules, and Diseases, 30, pp. 194-200. (doi: 10.1016/S1079-9796(03)00031-7)

Hanlon, L., Barr, N.I., Blyth, K. , Stewart, M., Haviernik, P., Wolff, L., Weston, K., Cameron, E.R. and Neil, J.C. (2003) Long-range effects of retroviral insertion on c-myb: Overexpression may be obscured by silencing during tumor growth in vitro. Journal of Virology, 77(2), pp. 1059-1068. (doi: 10.1128/JVI.77.2.1059-1068.2003) (PMID:12502821) (PMCID:PMC140821)

2002

Wotton, S., Stewart, M., Blyth, K. , Vaillant, F., Kilbey, A., Neil, J. C. and Cameron, E. R. (2002) Proviral insertion indicates a dominant oncogenic role for Runx1/AML-1 in T-cell lymphoma. Cancer Research, 62(24), pp. 7181-7185. (PMID:12499254)

Vaillant, F., Blyth, K. , Andrew, L., Neil, J. C. and Cameron, E. R. (2002) Enforced expression of Runx2 perturbs T cell development at a stage coincident with β-selection. Journal of Immunology, 169(6), pp. 2866-2874. (doi: 10.4049/jimmunol.169.6.2866)

2001

Baxter, E. W., Blyth, K. , Cameron, E. R. and Neil, J. C. (2001) Selection for loss of p53 function in T-cell lymphomagenesis is alleviated by Moloney murine leukemia virus infection in myc transgenic mice. Journal of Virology, 75(20), pp. 9790-9798. (doi: 10.1128/JVI.75.20.9790-9798.2001) (PMID:11559812) (PMCID:PMC114551)

Blyth, K. , Terry, A., Mackay, N., Vaillant, F., Bell, M., Cameron, E.R. , Neil, J.C. and Stewart, M. (2001) Runx2: A novel oncogenic effector revealed by in vivo complementation and retroviral tagging. Oncogene, 20(3), pp. 295-302. (doi: 10.1038/sj.onc.1204090) (PMID:11313958)

2000

Blyth, K. , Stewart, M., Bell, M., James, C., Evan, G., Neil, J. C. and Cameron, E. R. (2000) Sensitivity to myc-induced apoptosis is retained in spontaneous and transplanted lymphomas of CD2-mycERTM mice. Oncogene, 19(6), pp. 773-782. (doi: 10.1038/sj.onc.1203321) (PMID:10698495)

Cameron, E.R. , Morton, J. , Johnston, C.J., Irvine, J., Bell, M., Onions, D.E., Neil, J.C. , Campbell, M. and Blyth, K. (2000) Fas-independent apoptosis in T-cell tumours induced by the CD2-myc transgene. Cell Death and Differentiation, 7(1), pp. 80-88. (doi: 10.1038/sj.cdd.4400630) (PMID:10713723)

1999

Vaillant, F., Blyth, K. , Terry, A., Bell, M., Cameron, E. R. , Neil, J. and Stewart, M. (1999) A full-length Cbfa1 gene product perturbs T-cell development and promotes lymphomagenesis in synergy with myc. Oncogene, 18(50), pp. 7124-7134. (doi: 10.1038/sj.onc.1203202) (PMID:10597314)

Neil, J. , Stewart, M., Terry, A., O'Hara, M., Hu, M., Blyth, K. , Baxter, E., Onions, D. and Cameron, E. (1999) Identification of murine CBF alpha1, a runt domain transcription factor, as a putative Myc collaborator in T cell lymphoma. Leukemia, 13(S1), S83-S86. (doi: 10.1038/sj.leu.2401295) (PMID:10232373)

1998

Hall, A. P., Irvine, J., Blyth, K. , Cameron, E. R. , Onions, D. E. and Campbell, M. E.M. (1998) Tumours derived from HTLV-I tax transgenic mice are characterized by enhanced levels of apoptosis and oncogene expression. Journal of Pathology, 186(2), pp. 209-214. (doi: 10.1002/(SICI)1096-9896(1998100)186:2<209::AID-PATH162>3.0.CO;2-I) (PMID:9924438)

1997

Stewart, M., Terry, A., Hu, M., O'Hara, M., Blyth, K. , Baxter, E., Cameron, E. , Onions, D.E. and Neil, J.C. (1997) Proviral insertions induce the expression of bone-specific isoforms of PEBP2alphaA (CBFA1): evidence for a new myc collaborating oncogene. Proceedings of the National Academy of Sciences of the United States of America, 94(16), pp. 8646-8651. (doi: 10.1073/pnas.94.16.8646) (PMID:9238031) (PMCID:PMC23059)

1996

Baxter, E.W., Blyth, K. , Donehower, L., Cameron, E.R. , Onions, D.E. and Neil, J.C. (1996) Moloney murine leukemia virus-induced lymphomas in p53-deficient mice: overlapping pathways in tumor development? Journal of Virology, 70(4), pp. 2095-100. (PMID:8642629) (PMCID:PMC190045)

Cameron, E.R. , Campbell, M., Blyth, K. , Argyle, S.A., Keanie, L., Neil, J.C. and Onions, D.E. (1996) Apparent bypass of negative selection in CD8+ tumours in CD2-myc transgenic mice. British Journal of Cancer, 73(1), pp. 13-17. (doi: 10.1038/bjc.1996.3) (PMID:8554976) (PMCID:PMC2074291)

1995

Blyth, K. , Terry, A., O'Hara, M., Baxter, E.W., Campbell, M., Stewart, M., Donehower, L.A., Onions, D.E., Neil, J.C. and Cameron, E.R. (1995) Synergy between a human c-myc transgene and p53 null genotype in murine thymic lymphomas: contrasting effects of homozygous and heterozygous p53 loss. Oncogene, 10(9), pp. 1717-1723. (PMID:7753548)

1993

Stewart, M., Cameron, E., Campbell, M., McFarlane, R., Toth, S., Lang, K. , Onions, D. and Neil, J.C. (1993) Conditional expression and oncogenicity of c-myc linked to a CD2 gene dominant control region. International Journal of Cancer, 53(6), pp. 1023-30. (doi: 10.1002/ijc.2910530628) (PMID:8473043)

This list was generated on Tue Sep 21 07:08:32 2021 BST.
Number of items: 111.

Articles

McGarry, D. J., Armstrong, G., Castino, G., Mason, S., Clark, W., Shaw, R., McGarry, L., Blyth, K. and Olson, M. F. (2021) MICAL1 regulates actin cytoskeleton organization, directional cell migration and the growth of human breast cancer cells as orthotopic xenograft tumours. Cancer Letters, 519, pp. 226-236. (doi: 10.1016/j.canlet.2021.07.039) (PMID:34314753)

Campbell, K. J. et al. (2021) Breast cancer dependence on MCL-1 is due to its canonical anti-apoptotic function. Cell Death and Differentiation, 28(9), pp. 2589-2600. (doi: 10.1038/s41418-021-00773-4) (PMID:33785871) (PMCID:PMC8408186)

Newman, A. C., Falcone, M. , Huerta Uribe, A. , Zhang, T., Athineos, D., Pietzke, M., Vazquez, A. , Blyth, K. and Maddocks, O. D. K. (2021) Immune regulated IDO1-dependent tryptophan metabolism is source of one-carbon units for pancreatic cancer and stellate cells. Molecular Cell, 81(11), 2290-2302.e7. (doi: 10.1016/j.molcel.2021.03.019) (PMID:33831358)

Nacke, M. et al. (2021) An ARF GTPase module promoting invasion and metastasis through regulating phosphoinositide metabolism. Nature Communications, 12, 1623. (doi: 10.1038/s41467-021-21847-4) (PMID:33712589) (PMCID:PMC7955138)

Tajan, M. et al. (2021) Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy. Nature Communications, 12, 366. (doi: 10.1038/s41467-020-20223-y) (PMID:33446657) (PMCID:PMC7809039)

Latif, A.-L. et al. (2021) BRD4-mediated repression of p53 is a target for combination therapy in AML. Nature Communications, 12(1), 241. (doi: 10.1038/s41467-020-20378-8) (PMID:33431824) (PMCID:PMC7801601)

Mevel, R. et al. (2020) RUNX1 marks a luminal castration-resistant lineage established at the onset of prostate development. eLife, 9, e60225. (doi: 10.7554/elife.60225) (PMID:33025905) (PMCID:PMC7644213)

Zhang, T., Bauer, C., Newman, A. C., Uribe, A. H., Athineos, D., Blyth, K. and Maddocks, O. D.K. (2020) Polyamine pathway activity promotes cysteine essentiality in cancer cells. Nature Metabolism, 2, pp. 1062-1076. (doi: 10.1038/s42255-020-0253-2) (PMID:32747794)

Millar, R., Kilbey, A., Remak, S.-J., Severson, T. M., Dhayade, S., Sandilands, E., Foster, K., Bryant, D. M. , Blyth, K. and Coffelt, S. B. (2020) The MSP-RON axis stimulates cancer cell growth in models of triple negative breast cancer. Molecular Oncology, 14(8), pp. 1868-1880. (doi: 10.1002/1878-0261.12734) (PMID:32484599) (PMCID:PMC7400785)

Dhayade, S., Pietzke, M., Wiesheu, R., Tait-Mulder, J., Athineos, D., Sumpton, D., Coffelt, S. , Blyth, K. and Vazquez, A. (2020) Impact of formate supplementation on body weight and plasma amino acids. Nutrients, 12(8), 2181. (doi: 10.3390/nu12082181) (PMID:32708052) (PMCID:PMC7469024)

Rooney, N. et al. (2020) RUNX1 is a driver of renal cell carcinoma correlating with clinical outcome. Cancer Research, 80(11), pp. 2325-2339. (doi: 10.1158/0008-5472.CAN-19-3870) (PMID:32156779)

Oizel, K. et al. (2020) Formate induces a metabolic switch in nucleotide and energy metabolism. Cell Death and Disease, 11(5), 310. (doi: 10.1038/s41419-020-2523-z) (PMID:32366892) (PMCID:PMC7198490)

Campbell, K. J. and Blyth, K. (2020) Somatic base editing to model oncogenic drivers in breast cancer. Lab Animal, 49, pp. 115-116. (doi: 10.1038/s41684-020-0510-8) (PMID:32152514)

Lie-A-Ling, M., Mevel, R., Patel, R., Blyth, K. , Baena, E., Kouskoff, V. and Lacaud, G. (2020) RUNX1 dosage in development and cancer. Molecules and Cells, 43(2), pp. 126-138. (doi: 10.14348/molcells.2019.0301) (PMID:31991535) (PMCID:PMC7057845)

Sweeney, K., Cameron, E. R. and Blyth, K. (2020) Complex interplay between the RUNX transcription factors and Wnt/β-catenin pathway in cancer: a tango in the night. Molecules and Cells, 43(2), pp. 188-197. (doi: 10.14348/molcells.2019.0310) (PMID:32041394) (PMCID:PMC7057843)

MacKenzie, D. J. et al. (2020) DNMT3B Oncogenic Activity in Human Intestinal Cancer Is Not Linked to CIMP or BRAFV600E Mutation. iScience, 23(2), 100838. (doi: 10.1016/j.isci.2020.100838) (PMID:32058953) (PMCID:PMC7000804)

Cheung, E. C., DeNicola, G. M., Nixon, C., Blyth, K. , Labuschagne, C. F., Tuveson, D. A. and Vousden, K. (2020) Dynamic ROS control by TIGAR regulates the initiation and progression of pancreatic cancer. Cancer Cell, 37(2), 168-182.e4. (doi: 10.1016/j.ccell.2019.12.012) (PMID:31983610) (PMCID:PMC7008247)

Caraffini, V. et al. (2020) Loss of RAF kinase inhibitor protein is involved in myelomonocytic differentiation and aggravates RAS-driven myeloid leukemogenesis. Haematologica, 105(2), pp. 375-386. (doi: 10.3324/haematol.2018.209650) (PMID:31097632) (PMCID:PMC7012480)

Blagih, J. et al. (2020) Cancer-specific loss of p53 leads to a modulation of myeloid and T cell responses. Cell Reports, 30(2), 481-496.e6. (doi: 10.1016/j.celrep.2019.12.028) (PMID:31940491) (PMCID:31940491)

Loveridge, C. J. et al. (2020) BRF1 accelerates prostate tumourigenesis and perturbs immune infiltration. Oncogene, 39, pp. 1797-1806. (doi: 10.1038/s41388-019-1106-x) (PMID:31740786) (PMCID:PMC7033044)

Ran, R. et al. (2020) A role for CBFβ in maintaining the metastatic phenotype of breast cancer cells. Oncogene, 39, pp. 2624-2637. (doi: 10.1038/s41388-020-1170-2) (PMID:32005976) (PMCID:PMC7082223)

Liko, D. et al. (2019) Brf1 loss and not overexpression disrupts tissues homeostasis in the intestine, liver and pancreas. Cell Death and Differentiation, 26(12), pp. 2535-2550. (doi: 10.1038/s41418-019-0316-7) (PMID:30858608) (PMCID:PMC6861133)

Johnson, S. A., Ormsby, M. J., McIntosh, A., Tait, S. W.G. , Blyth, K. and Wall, D. M. (2019) Increasing the bactofection capacity of a mammalian expression vector by removal of the f1 ori. Cancer Gene Therapy, 26(7-8), pp. 183-194. (doi: 10.1038/s41417-018-0039-9) (PMID:30100607) (PMCID:PMC6760541)

Rudzka, D. A. et al. (2019) Migration through physical constraints is enabled by MAPK-induced cell softening via actin cytoskeleton re-organization. Journal of Cell Science, 132(11), jcs224071. (doi: 10.1242/jcs.224071) (PMID:31152052) (PMCID:PMC6589089)

Vande Voorde, J., Ackermann, T., Pfetzer, N., Sumpton, D., Mackay, G., Kalna, G., Nixon, C., Blyth, K. , Gottlieb, E. and Tardito, S. (2019) Improving the metabolic fidelity of cancer models with a physiological cell culture medium. Science Advances, 5(1), eaau7314. (doi: 10.1126/sciadv.aau7314) (PMID:30613774) (PMCID:PMC6314821)

Hassan, S. et al. (2019) A unique panel of patient-derived cutaneous squamous cell carcinoma cell lines provides a preclinical pathway for therapeutic testing. International Journal of Molecular Sciences, 20(14), 3428. (doi: 10.3390/ijms20143428) (PMID:31336867) (PMCID:PMC6678499)

Novo, D. et al. (2018) Mutant p53s generate pro-invasive niches by influencing exosome podocalyxin levels. Nature Communications, 9, 5069. (doi: 10.1038/s41467-018-07339-y) (PMID:30498210) (PMCID:PMC6265295)

Meiser, J. et al. (2018) Increased formate overflow is a hallmark of oxidative cancer. Nature Communications, 9, 1368. (doi: 10.1038/s41467-018-03777-w) (PMID:29636461) (PMCID:PMC5893600)

Campbell, K. J. et al. (2018) MCL-1 is a prognostic indicator and drug target in breast cancer. Cell Death and Disease, 9, 19. (doi: 10.1038/s41419-017-0035-2) (PMID:29339815) (PMCID:PMC5833338)

McCarroll, C. S. et al. (2018) Runx1 deficiency protects against adverse cardiac remodeling after myocardial infarction. Circulation, 137(1), pp. 57-70. (doi: 10.1161/CIRCULATIONAHA.117.028911) (PMID:29030345) (PMCID:PMC5757664)

Dornier, E. et al. (2017) Glutaminolysis drives membrane trafficking to promote invasiveness of breast cancer cells. Nature Communications, 8, 2255. (doi: 10.1038/s41467-017-02101-2) (PMID:29269878) (PMCID:PMC5740148)

Walton, J. B. et al. (2017) CRISPR/Cas9-derived models of ovarian high grade serous carcinoma targeting Brca1, Pten and Nf1, and correlation with platinum sensitivity. Scientific Reports, 7, 16827. (doi: 10.1038/s41598-017-17119-1) (PMID:29203787) (PMCID:PMC5715106)

Loveridge, C. J. et al. (2017) Analysis of Nkx3.1:Cre-driven Erk5 deletion reveals a profound spinal deformity which is linked to increased osteoclast activity. Scientific Reports, 7, 13241. (doi: 10.1038/s41598-017-13346-8) (PMID:29038439) (PMCID:PMC5643304)

van Tuyn, J. et al. (2017) Oncogene-expressing senescent melanocytes upregulate MhC class II, a candidate melanoma suppressor function. Journal of Investigative Dermatology, 137(10), pp. 2197-2207. (doi: 10.1016/j.jid.2017.05.030) (PMID:28647344) (PMCID:PMC5613751)

Giampazolias, E. et al. (2017) Mitochondrial permeabilization engages NF-κB-dependent anti-tumour activity under caspase deficiency. Nature Cell Biology, 19(9), pp. 1116-1129. (doi: 10.1038/ncb3596) (PMID:28846096) (PMCID:PMC5624512)

Reid, S. E. et al. (2017) Tumor matrix stiffness promotes metastatic cancer cell interaction with the endothelium. EMBO Journal, 36(16), pp. 2373-2389. (doi: 10.15252/embj.201694912) (PMID:28694244) (PMCID:PMC5556271)

Riggio, A. I. and Blyth, K. (2017) The enigmatic role of RUNX1 in female-related cancers - current knowledge & future perspectives. FEBS Journal, 284(15), pp. 2345-2362. (doi: 10.1111/febs.14059) (PMID:28304148)

Loveridge, C. J. et al. (2017) Increased T cell infiltration elicited by Erk5 deletion in a Pten-deficient mouse model of prostate carcinogenesis. Cancer Research, 77(12), pp. 3158-3168. (doi: 10.1158/0008-5472.CAN-16-2565) (PMID:28515147)

Hock, A. K. et al. (2017) Development of an inducible mouse model of iRFP713 to track recombinase activity and tumour development in vivo. Scientific Reports, 7, 1837. (doi: 10.1038/s41598-017-01741-0) (PMID:28500323) (PMCID:PMC5431786)

Maddocks, O. D.K. et al. (2017) Modulating the therapeutic response of tumours to dietary serine and glycine starvation. Nature, 544(7650), pp. 372-376. (doi: 10.1038/nature22056) (PMID:28425994)

Holen, I., Speirs, V., Morrissey, B. and Blyth, K. (2017) In vivo models in breast cancer research: progress, challenges and future directions. Disease Models and Mechanisms, 10(4), pp. 359-371. (doi: 10.1242/dmm.028274) (PMID:28381598) (PMCID:PMC5399571)

Hernandez-Fernaud, J. R. et al. (2017) Secreted CLIC3 drives cancer progression through its glutathione-dependent oxidoreductase activity. Nature Communications, 8, 14206. (doi: 10.1038/ncomms14206) (PMID:28198360) (PMCID:PMC5316871)

Bulusu, V. et al. (2017) Acetate recapturing by nuclear acetyl-CoA synthetase 2 prevents loss of histone acetylation during oxygen and serum limitation. Cell Reports, 18(3), pp. 647-658. (doi: 10.1016/j.celrep.2016.12.055) (PMID:28099844) (PMCID:PMC5276806)

Morrissey, B., Blyth, K. , Carter, P., Chelala, C., Jones, L., Holen, I. and Speirs, V. (2017) The sharing experimental animal resources, coordinating holdings (SEARCH) framework: encouraging reduction, replacement, and refinement in animal research. PLoS Biology, 15(1), e2000719. (doi: 10.1371/journal.pbio.2000719) (PMID:28081116) (PMCID:PMC5230739)

Weigert, M. et al. (2017) RIPK3 promotes adenovirus type 5 activity. Cell Death and Disease, 8, 3206. (doi: 10.1038/s41419-017-0110-8) (PMID:29238045) (PMCID:PMC5870599)

Meiser, J. et al. (2016) Serine one-carbon catabolism with formate overflow. Science Advances, 2(10), e1601273. (doi: 10.1126/sciadv.1601273) (PMID:27819051) (PMCID:PMC5091358)

Woodward, J. et al. (2016) Condensin II mutation causes T-cell lymphoma through tissue-specific genome instability. Genes and Development, 30(19), pp. 2173-2186. (doi: 10.1101/gad.284562.116) (PMID:27737961)

Birch, J. et al. (2016) The initiator methionine tRNA drives cell migration and invasion leading to increased metastatic potential in melanoma. Biology Open, 5(10), pp. 1371-1379. (doi: 10.1242/bio.019075) (PMID:27543055) (PMCID:PMC5087684)

Walton, J. et al. (2016) CRISPR/Cas9-mediated Trp53 and Brca2 knockout to generate improved murine models of ovarian high grade serous carcinoma. Cancer Research, 76(20), pp. 6118-6129. (doi: 10.1158/0008-5472.CAN-16-1272) (PMID:27530326) (PMCID:PMC5802386)

Speirs, V., Morrisey, B., Holen, I., Blyth, K. , Carter, P., Chelala, C. and Jones, L. (2016) SEARCHBreast: an online resource designed to increase the efficiency of using materials derived from breast cancer studies in animals. Journal of Pathology, 240(1), p. 120. (doi: 10.1002/path.4755) (PMID:27265197)

Carter, P., Blyth, K. , Holen, I., Jones, L., Morrissey, B., Speirs, V. and Chelala, C. (2016) The SEARCHBreast portal: a virtual bioresource to facilitate the sharing of surplus animal materials derived from breast cancer studies. Open Journal of Bioresources, 3(1), e4. (doi: 10.5334/ojb.21) (PMID:6323741) (PMCID:PMC255634)

Morrissey, B., Holen, I., Chelala, C., Carter, P., Jones, L., Blyth, K. and Speirs, V. (2016) Introducing SEARCHBreast: a virtual resource to facilitate sharing of surplus animal material developed for breast cancer research. npj Breast Cancer, 2, 16020. (doi: 10.1038/npjbcancer.2016.20) (PMID:28721381) (PMCID:PMC5515334)

Patella, F., Neilson, L., Athineos, D., Erami Rud Majani, Z., Anderson, K. I., Blyth, K. , Ryan, K. and Zanivan, S. R. (2016) In-depth proteomics identifies a role for autophagy in controlling reactive oxygen species mediated endothelial permeability. Journal of Proteome Research, 15(7), pp. 2187-2197. (doi: 10.1021/acs.jproteome.6b00166) (PMID:27246970)

Morrissey, B., Blyth, K. , Carter, P., Chelala, C., Jones, L., Holen, I. and Speirs, V. (2016) SEARCHBreast: a new online resource to make surplus material from in vivo models of breast cancer visible and accessible to researchers. Breast Cancer Research, 18, 59. (doi: 10.1186/s13058-016-0716-2) (PMID:27246323) (PMCID:PMC4888409)

Blyth, K. , Carter, P., Morrissey, B., Chelala, C., Jones, L., Holen, I. and Speirs, V. (2016) SEARCHBreast: a new resource to locate and share surplus archival material from breast cancer animal models to help address the 3Rs. Breast Cancer Research and Treatment, 156(3), pp. 447-452. (doi: 10.1007/s10549-016-3785-0) (PMID:27083180)

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Marusiak, A. A. et al. (2016) Recurrent MLK4 loss-of-function mutations suppress JNK signaling to promote colon tumorigenesis. Cancer Research, 76(3), pp. 724-735. (doi: 10.1158/0008-5472.can-15-0701-t) (PMID:26637668) (PMCID:PMC4740929)

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Ferrari, N., Mohammed, Z. M. A., Nixon, C., Mason, S. M., Mallon, E., McMillan, D. C. , Morris, J. S. , Cameron, E. R. , Edwards, J. and Blyth, K. (2014) Expression of RUNX1 correlates with poor patient prognosis in triple negative breast cancer. PLoS ONE, 9(6), e100759. (doi: 10.1371/journal.pone.0100759) (PMID:24967588) (PMCID:PMC4072705)

Cheung, E., Lee, P., Berkers, C., Blyth, K. , Sansom, O. and Vousden, K. (2014) The in vivo function of TIGAR, a p53 target gene that regulates glucose metabolism. Cancer and Metabolism, 2, P15. (doi: 10.1186/2049-3002-2-S1-P15) (PMCID:PMC4072993)

Li, A. et al. (2014) Fascin is regulated by slug, promotes progression of pancreatic cancer in mice, and is associated with patient outcomes. Gastroenterology, 146(5), 1386-1396.e17. (doi: 10.1053/j.gastro.2014.01.046) (PMID:24462734) (PMCID:PMC4000441)

McDonald, L. et al. (2014) RUNX2 correlates with subtype-specific breast cancer in a human tissue microarray, and ectopic expression of Runx2 perturbs differentiation in the mouse mammary gland. Disease Models and Mechanisms, 7(5), pp. 525-534. (doi: 10.1242/dmm.015040)

Hock, A. K., Lee, P., Maddocks, O. D. , Mason, S. M., Blyth, K. and Vousden, K. H. (2014) iRFP is a sensitive marker for cell number and tumor growth in high-throughput systems. Cell Cycle, 13(2), pp. 220-226. (doi: 10.4161/cc.26985)

Rai, T. S. et al. (2014) HIRA orchestrates a dynamic chromatin landscape in senescence and is required for suppression of neoplasia. Genes and Development, 28(24), pp. 2712-2725. (doi: 10.1101/gad.247528.114) (PMID:25512559) (PMCID:PMC4265675)

Pawlikowski, J.S., McBryan, T., van Tuyn, J., Drotar, M.E., Hewitt, R.N., Maier, A.B., King, A., Blyth, K. , Wu, H. and Adams, P.D. (2013) Wnt signaling potentiates nevogenesis. Proceedings of the National Academy of Sciences of the United States of America, 110(40), pp. 16009-16014. (doi: 10.1073/pnas.1303491110) (PMID:24043806) (PMCID:PMC3791768)

Cheung, E.C., Athineos, D., Lee, P., Ridgway, R.A., Lambie, W., Nixon, C., Strathdee, D., Blyth, K. , Sansom, O.J. and Vousden, K.H. (2013) TIGAR is required for efficient intestinal regeneration and tumorigenesis. Developmental Cell, 25(5), pp. 463-477. (doi: 10.1016/j.devcel.2013.05.001)

Ferrari, N., McDonald, L., Morris, J.S. , Cameron, E.R. and Blyth, K. (2013) RUNX2 in mammary gland development and breast cancer. Journal of Cellular Physiology, 228(6), pp. 1137-1142. (doi: 10.1002/jcp.24285)

Zheng, L., MacKenzie, E. D., Karim, S. A., Hedley, A., Blyth, K. , Kalna, G., Watson, D. G., Szlosarek, P., Frezza, C. and Gottlieb, E. (2013) Reversed argininosuccinate lyase activity in fumarate hydratase-deficient cancer cells. Cancer and Metabolism, 1, 12. (doi: 10.1186/2049-3002-1-12) (PMID:24280230) (PMCID:PMC4108060)

Maddocks, O.D.K. , Berkers, C.R., Mason, S.M., Zheng, L., Blyth, K. , Gottlieb, E. and Vousden, K.H. (2013) Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells. Nature, 493(7433), pp. 542-546. (doi: 10.1038/nature11743)

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Cheung, E. C., Athineos, D., Ridgway, R., Blyth, K. , Strathdee, D., Sansom, O. and Vousden, K. H. (2012) The in vivo function of the p53 target gene TIGAR. BMC Proceedings, 6, P12. (doi: 10.1186/1753-6561-6-S3-P12) (PMCID:PMC3395062)

Blyth, K. , Morton, J.P. and Sansom, O.J. (2012) The right time, the right place: will targeting human cancer-associated mutations to the mouse provide the perfect preclinical model? Current Opinion in Genetics and Development, 22(1), pp. 28-35. (doi: 10.1016/j.gde.2012.02.009)

Li, A., Ma, Y., Jin, M., Mason, S., Mort, R.L., Blyth, K. , Larue, L., Sansom, O.J. and Machesky, L.M. (2012) Activated mutant NRasQ61K drives aberrant melanocyte signaling, survival, and invasiveness via a rac1-Dependent mechanism. Journal of Investigative Dermatology, 132(11), pp. 2610-2621. (doi: 10.1038/jid.2012.186)

Zebisch, A. et al. (2012) Frequent loss of RAF kinase inhibitor protein expression in acute myeloid leukemia. Leukemia, 26(8), pp. 1842-1849. (doi: 10.1038/leu.2012.61)

Blyth, K. , Vaillant, F., Jenkins, A., McDonald, L., Pringle, M. A. , Huser, C. , Stein, T., Neil, J. and Cameron, E. R. (2010) Runx2 in normal tissues and cancer cells: A developing story. Blood Cells, Molecules, and Diseases, 45(2), pp. 117-123. (doi: 10.1016/j.bcmd.2010.05.007)

Woodcock, S., Rushton, H., Castañeda-Saucedo, E., Myant, K., White, G., Blyth, K. , Sansom, O. and Malliri, A. (2010) Tiam1-Rac Signaling Counteracts Eg5 during Bipolar Spindle Assembly to Facilitate Chromosome Congression. Current Biology, 20(7), pp. 669-675. (doi: 10.1016/j.cub.2010.02.033)

Blyth, K. , Slater, N., Hanlon, L., Bell, M., Mackay, N., Stewart, M., Neil, J.C. and Cameron, E.R. (2009) Runx1 promotes B-cell survival and lymphoma development. Blood Cells, Molecules, and Diseases, 43(1), pp. 12-19. (doi: 10.1016/j.bcmd.2009.01.013)

Scobie, L. et al. (2009) A novel model of SCID-X1 reconstitution reveals predisposition to retrovirus-induced lymphoma but no evidence of gammaC gene oncogenicity. Molecular Therapy, 17(6), pp. 1031-1038. (doi: 10.1038/mt.2009.59)

Stewart, M., Mackay, N., Hanlon, L., Blyth, K. , Scobie, L., Cameron, E. and Neil, J. (2007) Insertional mutagenesis reveals progression genes and checkpoints in MYC/Runx2 lymphomas. Cancer Research, 67(11), pp. 5126-5133. (doi: 10.1158/0008-5472.CAN-07-0433) (PMID:17545590) (PMCID:PMC2562448)

Kilbey, A., Blyth, K. , Wotton, S., Terry, A., Jenkins, A., Bell, M., Hanlon, L., Cameron, E.R. and Neil, J.C. (2007) Runx2 disruption promotes immortalization and confers resistance to oncogene-induced senescence in primary murine fibroblasts. Cancer Research, 67(23), pp. 11263-11271. (doi: 10.1158/0008-5472.CAN-07-3016)

Blyth, K. , Vaillant, F., Hanlon, L., Mackay, N., Bell, M., Jenkins, A., Neil, J.C. and Cameron, E.R. (2006) Runx2 and MYC collaborate in lymphoma development by suppressing apoptotic and growth arrest pathways in vivo. Cancer Research, 66(4), pp. 2195-2201. (doi: 10.1158/0008-5472.CAN-05-3558) (PMID:16489021)

Thrasher, A.J. et al. (2006) Gene therapy: X-SCID transgene leukaemogenicity. Nature, 443(7109), E5-E6. (doi: 10.1038/nature05219)

Blyth, K. , Cameron, E.R. and Neil, J.C. (2005) The RUNX genes: gain or loss of function in cancer. Nature Reviews Cancer, 5(5), pp. 376-387. (doi: 10.1038/nrc1607) (PMID:15864279)

Wotton, S. F., Blyth, K. , Kilbey, A., Jenkins, A., Terry, A., Bernardin-Fried, F., Friedman, A. D., Baxter, E. W., Neil, J. C. and Cameron, E. R. (2004) RUNX1 transformation of primary embryonic fibroblasts is revealed in the absence of p53. Oncogene, 23(32), pp. 5476-5486. (doi: 10.1038/sj.onc.1207729) (PMID:15133495)

Cameron, E. R., Blyth, K. , Hanlon, L., Kilbey, A., Mackay, N., Stewart, M., Terry, A., Vaillant, F., Wotton, S. and Neil, J. C. (2003) The Runx genes as dominant oncogenes. Blood Cells, Molecules, and Diseases, 30, pp. 194-200. (doi: 10.1016/S1079-9796(03)00031-7)

Hanlon, L., Barr, N.I., Blyth, K. , Stewart, M., Haviernik, P., Wolff, L., Weston, K., Cameron, E.R. and Neil, J.C. (2003) Long-range effects of retroviral insertion on c-myb: Overexpression may be obscured by silencing during tumor growth in vitro. Journal of Virology, 77(2), pp. 1059-1068. (doi: 10.1128/JVI.77.2.1059-1068.2003) (PMID:12502821) (PMCID:PMC140821)

Wotton, S., Stewart, M., Blyth, K. , Vaillant, F., Kilbey, A., Neil, J. C. and Cameron, E. R. (2002) Proviral insertion indicates a dominant oncogenic role for Runx1/AML-1 in T-cell lymphoma. Cancer Research, 62(24), pp. 7181-7185. (PMID:12499254)

Vaillant, F., Blyth, K. , Andrew, L., Neil, J. C. and Cameron, E. R. (2002) Enforced expression of Runx2 perturbs T cell development at a stage coincident with β-selection. Journal of Immunology, 169(6), pp. 2866-2874. (doi: 10.4049/jimmunol.169.6.2866)

Baxter, E. W., Blyth, K. , Cameron, E. R. and Neil, J. C. (2001) Selection for loss of p53 function in T-cell lymphomagenesis is alleviated by Moloney murine leukemia virus infection in myc transgenic mice. Journal of Virology, 75(20), pp. 9790-9798. (doi: 10.1128/JVI.75.20.9790-9798.2001) (PMID:11559812) (PMCID:PMC114551)

Blyth, K. , Terry, A., Mackay, N., Vaillant, F., Bell, M., Cameron, E.R. , Neil, J.C. and Stewart, M. (2001) Runx2: A novel oncogenic effector revealed by in vivo complementation and retroviral tagging. Oncogene, 20(3), pp. 295-302. (doi: 10.1038/sj.onc.1204090) (PMID:11313958)

Blyth, K. , Stewart, M., Bell, M., James, C., Evan, G., Neil, J. C. and Cameron, E. R. (2000) Sensitivity to myc-induced apoptosis is retained in spontaneous and transplanted lymphomas of CD2-mycERTM mice. Oncogene, 19(6), pp. 773-782. (doi: 10.1038/sj.onc.1203321) (PMID:10698495)

Cameron, E.R. , Morton, J. , Johnston, C.J., Irvine, J., Bell, M., Onions, D.E., Neil, J.C. , Campbell, M. and Blyth, K. (2000) Fas-independent apoptosis in T-cell tumours induced by the CD2-myc transgene. Cell Death and Differentiation, 7(1), pp. 80-88. (doi: 10.1038/sj.cdd.4400630) (PMID:10713723)

Vaillant, F., Blyth, K. , Terry, A., Bell, M., Cameron, E. R. , Neil, J. and Stewart, M. (1999) A full-length Cbfa1 gene product perturbs T-cell development and promotes lymphomagenesis in synergy with myc. Oncogene, 18(50), pp. 7124-7134. (doi: 10.1038/sj.onc.1203202) (PMID:10597314)

Neil, J. , Stewart, M., Terry, A., O'Hara, M., Hu, M., Blyth, K. , Baxter, E., Onions, D. and Cameron, E. (1999) Identification of murine CBF alpha1, a runt domain transcription factor, as a putative Myc collaborator in T cell lymphoma. Leukemia, 13(S1), S83-S86. (doi: 10.1038/sj.leu.2401295) (PMID:10232373)

Hall, A. P., Irvine, J., Blyth, K. , Cameron, E. R. , Onions, D. E. and Campbell, M. E.M. (1998) Tumours derived from HTLV-I tax transgenic mice are characterized by enhanced levels of apoptosis and oncogene expression. Journal of Pathology, 186(2), pp. 209-214. (doi: 10.1002/(SICI)1096-9896(1998100)186:2<209::AID-PATH162>3.0.CO;2-I) (PMID:9924438)

Stewart, M., Terry, A., Hu, M., O'Hara, M., Blyth, K. , Baxter, E., Cameron, E. , Onions, D.E. and Neil, J.C. (1997) Proviral insertions induce the expression of bone-specific isoforms of PEBP2alphaA (CBFA1): evidence for a new myc collaborating oncogene. Proceedings of the National Academy of Sciences of the United States of America, 94(16), pp. 8646-8651. (doi: 10.1073/pnas.94.16.8646) (PMID:9238031) (PMCID:PMC23059)

Baxter, E.W., Blyth, K. , Donehower, L., Cameron, E.R. , Onions, D.E. and Neil, J.C. (1996) Moloney murine leukemia virus-induced lymphomas in p53-deficient mice: overlapping pathways in tumor development? Journal of Virology, 70(4), pp. 2095-100. (PMID:8642629) (PMCID:PMC190045)

Cameron, E.R. , Campbell, M., Blyth, K. , Argyle, S.A., Keanie, L., Neil, J.C. and Onions, D.E. (1996) Apparent bypass of negative selection in CD8+ tumours in CD2-myc transgenic mice. British Journal of Cancer, 73(1), pp. 13-17. (doi: 10.1038/bjc.1996.3) (PMID:8554976) (PMCID:PMC2074291)

Blyth, K. , Terry, A., O'Hara, M., Baxter, E.W., Campbell, M., Stewart, M., Donehower, L.A., Onions, D.E., Neil, J.C. and Cameron, E.R. (1995) Synergy between a human c-myc transgene and p53 null genotype in murine thymic lymphomas: contrasting effects of homozygous and heterozygous p53 loss. Oncogene, 10(9), pp. 1717-1723. (PMID:7753548)

Stewart, M., Cameron, E., Campbell, M., McFarlane, R., Toth, S., Lang, K. , Onions, D. and Neil, J.C. (1993) Conditional expression and oncogenicity of c-myc linked to a CD2 gene dominant control region. International Journal of Cancer, 53(6), pp. 1023-30. (doi: 10.1002/ijc.2910530628) (PMID:8473043)

Book Sections

Rooney, N., Riggio, A. I., Mendoza-Villanueva, D., Shore, P., Cameron, E. R. and Blyth, K. (2017) Runx genes in breast cancer and the mammary lineage. In: Groner, Y., Ito, Y., Liu, P., Neil, J. C., Speck, N. A. and van Wijnen, A. (eds.) RUNX Proteins in Development and Cancer. Series: Advances in experimental medicine and biology, 96 (962). Springer, pp. 353-368. ISBN 9789811032318 (doi:10.1007/978-981-10-3233-2_22)

This list was generated on Tue Sep 21 07:08:32 2021 BST.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Evaluation of metabotropic glutamate receptor 3 as a therapeutic target in breast cancer.
    Breast Cancer Now
    2019 - 2022
     
  • Regulation of IL-17-producing T cells in breast cancer metastasis
    Breast Cancer Now
    2019 - 2021
     
  • Targeting MCL-1 in breast cancer
    Breast Cancer Now
    2016 - 2019
     
  • Annexin A8's role in progenitor cell maintenance within the cells of origin of basal-like breast cancers.
    Breast Cancer Now
    2013 - 2016
     
  • The role of Runx2 in mammary development and breast cancer
    Association for International Cancer Research
    2008 - 2008