2024

Pennel, K. A.F. et al. (2024) JAK/STAT3 represents a therapeutic target for colorectal cancer patients with stromal-rich tumors. Journal of Experimental and Clinical Cancer Research, 43, 64. (doi: 10.1186/s13046-024-02958-4)

2023

Zaweia, R., Alyamani, A., McMenemy, C. , Quinn, J. and Greenhalgh, D. (2023) Inducible E-cadherin Ablation Drives Malignant Progression in HK1.ras.fos.PTENflx/flx Carcinogenesis and Induces Conversion of HK1.fos.PTENflx/flx Keratoacanthoma. British Journal of Dermatology 189(1):e23. Meeting Abstract: British Society for Investigative Dermatology (BSID) Annual Meeting, Technology & Innovation Centre, University of Strathclyde, Glasgow, Scotland, 20–21 March 2023. (doi: 10.1093/bjd/ljad174.044)

Hatthakarnkul, P. et al. (2023) Protein expression of S100A2 reveals it association with patient prognosis and immune infiltration profile in colorectal cancer. Journal of Cancer, 14(10), pp. 1837-1847. (doi: 10.7150/jca.83910) (PMID:37476187) (PMCID:PMC10355195)

Wood, C. S. et al. (2023) Spatially resolved transcriptomics deconvolutes prognostic histological subgroups in patients with colorectal cancer and synchronous liver metastases. Cancer Research, 83(8), pp. 1329-1344. (doi: 10.1158/0008-5472.CAN-22-2794) (PMID:37057593) (PMCID:PMC10102851)

Numprasit, W., Yangngam, S., Prasopsiri, J., Quinn, J. A. , Edwards, J. and Thuwajit, C. (2023) Carbonic anhydrase IX-related tumoral hypoxia predicts worse prognosis in breast cancer: a systematic review and meta-analysis. Frontiers in Medicine, 10, 1087270. (doi: 10.3389/fmed.2023.1087270) (PMID:37007798) (PMCID:PMC10063856)

Tandon, V., Moreno, R., Allmeroth, K., Quinn, J. , Wiley, S. E., Nicely, L. G., Denzel, M. S., Edwards, J. , de la Vega, L. and Banerjee, S. (2023) Dual inhibition of HSF1 and DYRK2 impedes cancer progression. Bioscience Reports, 34(1), BSR2022210. (doi: 10.1042/BSR20222102) (PMID:36622366) (PMCID:PMC9894012)

2022

Pennel, K. A. F. et al. (2022) CXCL8 expression is associated with advanced stage, right sidedness, and distinct histological features of colorectal cancer. Journal of Pathology: Clinical Research, 8(6), pp. 509-520. (doi: 10.1002/cjp2.290) (PMID:35879507) (PMCID:PMC9535100)

Alexander, P. G. et al. (2022) The relationship between the Glasgow Microenvironment Score and markers of epithelial-mesenchymal transition in TNM II-III colorectal cancer. Human Pathology, 127, pp. 1-11. (doi: 10.1016/j.humpath.2022.05.012) (PMID:35623467)

Shamis, S. A.K., Quinn, J. , Mallon, E. E.A., Edwards, J. and McMillan, D. C. (2022) The relationship between the tumor cell expression of hypoxic markers and survival in patients with ER-positive invasive ductal breast cancer. Journal of Histochemistry and Cytochemistry, 70(7), pp. 479-494. (doi: 10.1369/00221554221110280) (PMID:35792080)

Patel, M. et al. (2022) Spatial expression of IKK-alpha is associated with a differential mutational landscape and survival in primary colorectal cancer. British Journal of Cancer, 126(12), pp. 1704-1714. (doi: 10.1038/s41416-022-01729-2) (PMID:35173303) (PMCID:PMC9174220)

Zaweia, R., McMenemy, C. , Quinn, J. and Greenhalgh, D. (2022) E-cadherin Loss Cooperates with RasHa Activation to Drive Malignant Progression in Transgenic Mouse Skin Carcinogenesis. British Journal of Dermatology 186(6):e232-e233. Meeting Abstract: British Society for Investigative Dermatology Annual Meeting, Frederick Douglass Centre, Newcastle University, Newcastle Upon Tyne, 4-6 April 2022. (doi: 10.1111/bjd.21248)

Hatthakarnkul, P. , Quinn, J. A. , Ammar, A. , Lynch, G., Van Wyk, H. , McMillan, D. C. , Thuwajit, C. and Edwards, J. (2022) Molecular mechanisms of tumour budding and its association with microenvironment in colorectal cancer. Clinical Science, 136(8), pp. 521-535. (doi: 10.1042/CS20210886) (PMID:35445707)

2021

Matly, A., Quinn, J. A. , McMillan, D. C. , Park, J. H. and Edwards, J. (2021) The relationship between β-catenin and patient survival in colorectal cancer systematic review and meta-analysis. Critical Reviews in Oncology/Hematology, 163, 103337. (doi: 10.1016/j.critrevonc.2021.103337) (PMID:33992802)

Moreno, R., Banerjee, S., Jackson, A. W., Quinn, J. , Baillie, G., Dixon, J. E., Dinkova-Kostova, A. T., Edwards, J. and de la Vega, L. (2021) The stress-responsive kinase DYRK2 activates heat shock factor 1 promoting resistance to proteotoxic stress. Cell Death and Differentiation, 28(5), pp. 1563-1578. (doi: 10.1038/s41418-020-00686-8) (PMID:33268814)

Al-Badran, S. S.F. et al. (2021) Relationship between immune checkpoint proteins, tumour microenvironment characteristics, and prognosis in primary operable colorectal cancer. Journal of Pathology: Clinical Research, 7(2), pp. 121-134. (doi: 10.1002/cjp2.193) (PMID:33338327)

Hatthakarnkul, P. , Quinn, J. A. , Matly, A. A. M., Ammar, A. , Van Wyk, H. C. , McMillan, D. C. and Edwards, J. (2021) Systematic review of tumour budding and association with common mutations in patients with colorectal cancer. Critical Reviews in Oncology/Hematology, 167, 103490. (doi: 10.1016/j.critrevonc.2021.103490) (PMID:34619332)

2020

Torrente, L. et al. (2020) High NRF2 levels correlate with poor prognosis in colorectal cancer patients and with sensitivity to the kinase inhibitor AT9283 in vitro. Biomolecules, 10(10), 1365. (doi: 10.3390/biom10101365) (PMID:32992842) (PMCID:PMC7600603)

Quinn, J. A. , Bennett, L., Patel, M., Frixou, M., Park, J. H., Roseweir, A., Horgan, P. G., McMillan, D. C. and Edwards, J. (2020) The relationship between members of the canonical NF-kB pathway, tumour microenvironment and cancer specific survival in colorectal cancer patients. Histology and Histopathology: Cellular and Molecular Biology, 35(6), pp. 569-578. (doi: 10.14670/HH-18-168) (PMID:31592535)

2019

Alyamani, A.M.A., Quinn, J.A. and Greenhalgh, D.A. (2019) Activated β-catenin Expression Inhibits Papillomas in HK1.ras Transgenic Mice Via Increased p53/p21-Associated Differentiation. British Journal of Dermatology 180(6): e186. Meeting Abstract: British Society for Investigative Dermatology Annual Meeting, Bradford, UK, 01-03 Apr 2019. (doi: 10.1111/bjd.17776)

McMenemy, C. , Quinn, J.A. and Greenhalgh, D.A. (2019) Epidermal-Specific 14-3-3σ/Stratifin Overexpressioninduces Malignant Conversion of Aggressive, Rapid-growth Papillomas, but not Slower, Regression-prone Papillomas. British Journal of Dermatology 180(6): e203. Meeting Abstract: British Society for Investigative Dermatology Annual Meeting, Bradford, UK, 01-03 Apr 2019. (doi: 10.1111/bjd.17776)

Roseweir, A. K. , Clark, J., McSorley, S. T. , vanWyk, H. C. , Quinn, J. A. , Horgan, P. G. , McMillan, D. C. , Park, J. H. and Edwards, J. (2019) The association between markers of tumour cell metabolism, the tumour microenvironment and outcomes in patients with colorectal cancer. International Journal of Cancer, 144(9), pp. 2320-2329. (doi: 10.1002/ijc.32045) (PMID:30521130)

Roseweir, A.K. et al. (2019) A novel tumor-based epithelial-to-mesenchymal transition score that associates with prognosis and metastasis in patients with stage II/III colorectal cancer. International Journal of Cancer, 144(1), pp. 150-159. (doi: 10.1002/ijc.31739) (PMID:29992570)

2018

Alyamani, A.M.A., Quinn, J.A. and Greenhalgh, D. A. (2018) Analysis of β-catenin expression in transgenic mouse skin carcinogenesis reveals inhibitory roles in papillomatogenesis and oncogenic roles in malignant conversion. BSID Annual Meeting 2018, London, UK, 26-28 Mar 2018.

McMenemy, C. , Quinn, J.A. and Greenhalgh, D. A. (2018) Fos co-operation with 14-3-3σ [Stratifin] induces malignant conversion in transgenic mouse skin carcinogenesis: a paradigm for SCC of follicular origin. BSID Annual Meeting 2018, London, UK, 26-28 Mar 2018.

2017

Bennett, L., Quinn, J. , McCall, P., Mallon, E. A., Horgan, P. G. , McMillan, D. C. , Paul, A. and Edwards, J. (2017) High IKKα expression is associated with reduced time to recurrence and cancer specific survival in oestrogen receptor (ER)-positive breast cancer. International Journal of Cancer, 140(7), pp. 1633-1644. (doi: 10.1002/ijc.30578) (PMID:28006839)

Park, J. H. , Van Wyk, H. C., McMillan, D. C. , Quinn, J. A. , Clark, J., Roxburgh, C. , Horgan, P. G. and Edwards, J. (2017) Signal transduction and activator of transcription-3 (STAT3) in patients with colorectal cancer: associations with the phenotypic features of the tumour and host. Clinical Cancer Research, 23(7), pp. 1698-1709. (doi: 10.1158/1078-0432.CCR-16-1416) (PMID:27678454)

McMenemy, C. , Guo, D., Cochrane, A., Crookston, K., Boyle, J., Quinn, J. and Greenhalgh, D. A. (2017) 14-3-3σ/Stratifin Expression in HK1.Ras/Fos-Δ5ptenflx Transgenic Mouse Skin Carcinogenesis Reveals an Early, Inhibitory Role; Lost During MDM2 Activated/P53 Inactivated Malignant Progression. British Society for Investigative Dermatology (BSID) Annual Meeting, Manchester, UK, 3-5 April 2017.

2014

Macdonald, F., Yao, D., Quinn, J. and Greenhalgh, D. (2014) PTEN ablation in RasHa/Fos skin carcinogenesis invokes p53-dependent p21 to delay conversion while p53-independent p21 limits progression via cyclin D1/E2 inhibition. Oncogene, 33(32), pp. 4132-4143. (doi: 10.1038/onc.2013.372)

2013

Macdonald, F.H., Yao, D., Quinn, J.A. and Greenhalgh, D.A. (2013) Activated p-AKT, but not MDM2, drives malignant progression in Ras/Fos/PTEN^null skin carcinogenesis via p53/p21 loss and elevated cyclin D1/E2 expression. Journal of Investigative Dermatology, 133(S1), S57-S57. (doi: 10.1038/jid.2013.96)

Nobis, M. et al. (2013) Intravital FLIM-FRET imaging reveals dasatinib-induced spatial control of Src in pancreatic cancer. Cancer Research, 73(15), pp. 4674-4686. (doi: 10.1158/0008-5472.CAN-12-4545)

2011

MacDonald, F.H., Quinn, J.A. and Greenhalgh, D.A. (2011) Skin carcinogenesis in Ras/fos/PTEN^null transgenic mice associates reveals mTOR association with papillomatogenesis/conversion and AKT with malignant progression. British Journal of Dermatology, 164(4), p. 934. (doi: 10.1111/j.1365-2133.2011.10279.x)

Edward, M., Quinn, J.A. and Sands, W. (2011) Keratinocytes stimulate fibroblast hyaluronan synthesis through the release of stratifin: A possible role in the suppression of scar tissue formation. Wound Repair and Regeneration, 19(3), pp. 379-386. (doi: 10.1111/j.1524-475X.2011.00678.x)

Timpson, P. et al. (2011) Spatial Regulation of RhoA Activity during Pancreatic Cancer Cell Invasion Driven by Mutant p53. Cancer Research, 71(3), pp. 747-757. (doi: 10.1158/0008-5472.CAN-10-2267)

2010

Edward, M., Quinn, J.A. , Pasonen-Seppanen, S.M., McCann, B.A. and Tammi, R.H. (2010) 4-Methylumbelliferone inhibits tumour cell growth and the activation of stromal hyaluronan synthesis by melanoma cell-derived factors. British Journal of Dermatology, 162(6), pp. 1224-1232. (doi: 10.1111/j.1365-2133.2010.09699.x)

Katz, E. et al. (2010) A gene on the HER2 amplicon, C35, is an oncogene in breast cancer whose actions are prevented by inhibition of Syk. British Journal of Cancer, 103(3), p. 401. (doi: 10.1038/sj.bjc.6605763)

2009

Greenhalgh, D. , Yao, D., Quinn, J. and Macdonald, F. (2009) RasHa activation interdicts compensatory p53/p21WAF expression in Fos/PTENnull skin carcinogenesis via initial p53 loss but retention of p21WAF limits malignant progression. In: American Association for Cancer Research (AACR) 100th Annual Meeting, Denver, USA, 18-22 April 2009,

Macdonald, F., Yao, D., Quinn, J. and Greenhalgh, D. (2009) Compensatory p53/p21WAF-induced differentiation in Fos/PTENnull skin carcinogenesis is interdicted by RasHa activation but retention of p21WAF inhibits malignant progression. In: British Society for Investigative Dermatology (BSID) Annual Meeting, Royal Agricultural College, Cirencester, UK, 30 March - 1 April 2009,

2008

Edward, M., Quinn, J.A., Mukherjee, S., Jensen, M.B., Jardine, A.G., Mark, P. and Burden, A. (2008) Gadodiamide contrast agent 'activates' fibroblasts: a possible cause of nephrogenic systemic fibrosis. Journal of Pathology, 214(5), pp. 584-593. (doi: 10.1002/path.2311)

Yao, D., Alexander, C., Quinn, J. , Chan, W., Wu, H. and Greenhalgh, D. (2008) Fos cooperation with PTEN loss elicits keratoacanthoma not carcinoma, owing to p53/p21(WAF)-induced differentiation triggered by GSK3 beta inactivation and reduced AKT activity. Journal of Cell Science, 121(10), pp. 1758-1769.

Articles

Pennel, K. A.F. et al. (2024) JAK/STAT3 represents a therapeutic target for colorectal cancer patients with stromal-rich tumors. Journal of Experimental and Clinical Cancer Research, 43, 64. (doi: 10.1186/s13046-024-02958-4)

Hatthakarnkul, P. et al. (2023) Protein expression of S100A2 reveals it association with patient prognosis and immune infiltration profile in colorectal cancer. Journal of Cancer, 14(10), pp. 1837-1847. (doi: 10.7150/jca.83910) (PMID:37476187) (PMCID:PMC10355195)

Wood, C. S. et al. (2023) Spatially resolved transcriptomics deconvolutes prognostic histological subgroups in patients with colorectal cancer and synchronous liver metastases. Cancer Research, 83(8), pp. 1329-1344. (doi: 10.1158/0008-5472.CAN-22-2794) (PMID:37057593) (PMCID:PMC10102851)

Numprasit, W., Yangngam, S., Prasopsiri, J., Quinn, J. A. , Edwards, J. and Thuwajit, C. (2023) Carbonic anhydrase IX-related tumoral hypoxia predicts worse prognosis in breast cancer: a systematic review and meta-analysis. Frontiers in Medicine, 10, 1087270. (doi: 10.3389/fmed.2023.1087270) (PMID:37007798) (PMCID:PMC10063856)

Tandon, V., Moreno, R., Allmeroth, K., Quinn, J. , Wiley, S. E., Nicely, L. G., Denzel, M. S., Edwards, J. , de la Vega, L. and Banerjee, S. (2023) Dual inhibition of HSF1 and DYRK2 impedes cancer progression. Bioscience Reports, 34(1), BSR2022210. (doi: 10.1042/BSR20222102) (PMID:36622366) (PMCID:PMC9894012)

Pennel, K. A. F. et al. (2022) CXCL8 expression is associated with advanced stage, right sidedness, and distinct histological features of colorectal cancer. Journal of Pathology: Clinical Research, 8(6), pp. 509-520. (doi: 10.1002/cjp2.290) (PMID:35879507) (PMCID:PMC9535100)

Alexander, P. G. et al. (2022) The relationship between the Glasgow Microenvironment Score and markers of epithelial-mesenchymal transition in TNM II-III colorectal cancer. Human Pathology, 127, pp. 1-11. (doi: 10.1016/j.humpath.2022.05.012) (PMID:35623467)

Shamis, S. A.K., Quinn, J. , Mallon, E. E.A., Edwards, J. and McMillan, D. C. (2022) The relationship between the tumor cell expression of hypoxic markers and survival in patients with ER-positive invasive ductal breast cancer. Journal of Histochemistry and Cytochemistry, 70(7), pp. 479-494. (doi: 10.1369/00221554221110280) (PMID:35792080)

Patel, M. et al. (2022) Spatial expression of IKK-alpha is associated with a differential mutational landscape and survival in primary colorectal cancer. British Journal of Cancer, 126(12), pp. 1704-1714. (doi: 10.1038/s41416-022-01729-2) (PMID:35173303) (PMCID:PMC9174220)

Hatthakarnkul, P. , Quinn, J. A. , Ammar, A. , Lynch, G., Van Wyk, H. , McMillan, D. C. , Thuwajit, C. and Edwards, J. (2022) Molecular mechanisms of tumour budding and its association with microenvironment in colorectal cancer. Clinical Science, 136(8), pp. 521-535. (doi: 10.1042/CS20210886) (PMID:35445707)

Matly, A., Quinn, J. A. , McMillan, D. C. , Park, J. H. and Edwards, J. (2021) The relationship between β-catenin and patient survival in colorectal cancer systematic review and meta-analysis. Critical Reviews in Oncology/Hematology, 163, 103337. (doi: 10.1016/j.critrevonc.2021.103337) (PMID:33992802)

Moreno, R., Banerjee, S., Jackson, A. W., Quinn, J. , Baillie, G., Dixon, J. E., Dinkova-Kostova, A. T., Edwards, J. and de la Vega, L. (2021) The stress-responsive kinase DYRK2 activates heat shock factor 1 promoting resistance to proteotoxic stress. Cell Death and Differentiation, 28(5), pp. 1563-1578. (doi: 10.1038/s41418-020-00686-8) (PMID:33268814)

Al-Badran, S. S.F. et al. (2021) Relationship between immune checkpoint proteins, tumour microenvironment characteristics, and prognosis in primary operable colorectal cancer. Journal of Pathology: Clinical Research, 7(2), pp. 121-134. (doi: 10.1002/cjp2.193) (PMID:33338327)

Hatthakarnkul, P. , Quinn, J. A. , Matly, A. A. M., Ammar, A. , Van Wyk, H. C. , McMillan, D. C. and Edwards, J. (2021) Systematic review of tumour budding and association with common mutations in patients with colorectal cancer. Critical Reviews in Oncology/Hematology, 167, 103490. (doi: 10.1016/j.critrevonc.2021.103490) (PMID:34619332)

Torrente, L. et al. (2020) High NRF2 levels correlate with poor prognosis in colorectal cancer patients and with sensitivity to the kinase inhibitor AT9283 in vitro. Biomolecules, 10(10), 1365. (doi: 10.3390/biom10101365) (PMID:32992842) (PMCID:PMC7600603)

Quinn, J. A. , Bennett, L., Patel, M., Frixou, M., Park, J. H., Roseweir, A., Horgan, P. G., McMillan, D. C. and Edwards, J. (2020) The relationship between members of the canonical NF-kB pathway, tumour microenvironment and cancer specific survival in colorectal cancer patients. Histology and Histopathology: Cellular and Molecular Biology, 35(6), pp. 569-578. (doi: 10.14670/HH-18-168) (PMID:31592535)

Roseweir, A. K. , Clark, J., McSorley, S. T. , vanWyk, H. C. , Quinn, J. A. , Horgan, P. G. , McMillan, D. C. , Park, J. H. and Edwards, J. (2019) The association between markers of tumour cell metabolism, the tumour microenvironment and outcomes in patients with colorectal cancer. International Journal of Cancer, 144(9), pp. 2320-2329. (doi: 10.1002/ijc.32045) (PMID:30521130)

Roseweir, A.K. et al. (2019) A novel tumor-based epithelial-to-mesenchymal transition score that associates with prognosis and metastasis in patients with stage II/III colorectal cancer. International Journal of Cancer, 144(1), pp. 150-159. (doi: 10.1002/ijc.31739) (PMID:29992570)

Bennett, L., Quinn, J. , McCall, P., Mallon, E. A., Horgan, P. G. , McMillan, D. C. , Paul, A. and Edwards, J. (2017) High IKKα expression is associated with reduced time to recurrence and cancer specific survival in oestrogen receptor (ER)-positive breast cancer. International Journal of Cancer, 140(7), pp. 1633-1644. (doi: 10.1002/ijc.30578) (PMID:28006839)

Park, J. H. , Van Wyk, H. C., McMillan, D. C. , Quinn, J. A. , Clark, J., Roxburgh, C. , Horgan, P. G. and Edwards, J. (2017) Signal transduction and activator of transcription-3 (STAT3) in patients with colorectal cancer: associations with the phenotypic features of the tumour and host. Clinical Cancer Research, 23(7), pp. 1698-1709. (doi: 10.1158/1078-0432.CCR-16-1416) (PMID:27678454)

Macdonald, F., Yao, D., Quinn, J. and Greenhalgh, D. (2014) PTEN ablation in RasHa/Fos skin carcinogenesis invokes p53-dependent p21 to delay conversion while p53-independent p21 limits progression via cyclin D1/E2 inhibition. Oncogene, 33(32), pp. 4132-4143. (doi: 10.1038/onc.2013.372)

Macdonald, F.H., Yao, D., Quinn, J.A. and Greenhalgh, D.A. (2013) Activated p-AKT, but not MDM2, drives malignant progression in Ras/Fos/PTEN^null skin carcinogenesis via p53/p21 loss and elevated cyclin D1/E2 expression. Journal of Investigative Dermatology, 133(S1), S57-S57. (doi: 10.1038/jid.2013.96)

Nobis, M. et al. (2013) Intravital FLIM-FRET imaging reveals dasatinib-induced spatial control of Src in pancreatic cancer. Cancer Research, 73(15), pp. 4674-4686. (doi: 10.1158/0008-5472.CAN-12-4545)

MacDonald, F.H., Quinn, J.A. and Greenhalgh, D.A. (2011) Skin carcinogenesis in Ras/fos/PTEN^null transgenic mice associates reveals mTOR association with papillomatogenesis/conversion and AKT with malignant progression. British Journal of Dermatology, 164(4), p. 934. (doi: 10.1111/j.1365-2133.2011.10279.x)

Edward, M., Quinn, J.A. and Sands, W. (2011) Keratinocytes stimulate fibroblast hyaluronan synthesis through the release of stratifin: A possible role in the suppression of scar tissue formation. Wound Repair and Regeneration, 19(3), pp. 379-386. (doi: 10.1111/j.1524-475X.2011.00678.x)

Timpson, P. et al. (2011) Spatial Regulation of RhoA Activity during Pancreatic Cancer Cell Invasion Driven by Mutant p53. Cancer Research, 71(3), pp. 747-757. (doi: 10.1158/0008-5472.CAN-10-2267)

Edward, M., Quinn, J.A. , Pasonen-Seppanen, S.M., McCann, B.A. and Tammi, R.H. (2010) 4-Methylumbelliferone inhibits tumour cell growth and the activation of stromal hyaluronan synthesis by melanoma cell-derived factors. British Journal of Dermatology, 162(6), pp. 1224-1232. (doi: 10.1111/j.1365-2133.2010.09699.x)

Katz, E. et al. (2010) A gene on the HER2 amplicon, C35, is an oncogene in breast cancer whose actions are prevented by inhibition of Syk. British Journal of Cancer, 103(3), p. 401. (doi: 10.1038/sj.bjc.6605763)

Edward, M., Quinn, J.A., Mukherjee, S., Jensen, M.B., Jardine, A.G., Mark, P. and Burden, A. (2008) Gadodiamide contrast agent 'activates' fibroblasts: a possible cause of nephrogenic systemic fibrosis. Journal of Pathology, 214(5), pp. 584-593. (doi: 10.1002/path.2311)

Yao, D., Alexander, C., Quinn, J. , Chan, W., Wu, H. and Greenhalgh, D. (2008) Fos cooperation with PTEN loss elicits keratoacanthoma not carcinoma, owing to p53/p21(WAF)-induced differentiation triggered by GSK3 beta inactivation and reduced AKT activity. Journal of Cell Science, 121(10), pp. 1758-1769.

Conference or Workshop Item

Zaweia, R., Alyamani, A., McMenemy, C. , Quinn, J. and Greenhalgh, D. (2023) Inducible E-cadherin Ablation Drives Malignant Progression in HK1.ras.fos.PTENflx/flx Carcinogenesis and Induces Conversion of HK1.fos.PTENflx/flx Keratoacanthoma. British Journal of Dermatology 189(1):e23. Meeting Abstract: British Society for Investigative Dermatology (BSID) Annual Meeting, Technology & Innovation Centre, University of Strathclyde, Glasgow, Scotland, 20–21 March 2023. (doi: 10.1093/bjd/ljad174.044)

Zaweia, R., McMenemy, C. , Quinn, J. and Greenhalgh, D. (2022) E-cadherin Loss Cooperates with RasHa Activation to Drive Malignant Progression in Transgenic Mouse Skin Carcinogenesis. British Journal of Dermatology 186(6):e232-e233. Meeting Abstract: British Society for Investigative Dermatology Annual Meeting, Frederick Douglass Centre, Newcastle University, Newcastle Upon Tyne, 4-6 April 2022. (doi: 10.1111/bjd.21248)

Alyamani, A.M.A., Quinn, J.A. and Greenhalgh, D.A. (2019) Activated β-catenin Expression Inhibits Papillomas in HK1.ras Transgenic Mice Via Increased p53/p21-Associated Differentiation. British Journal of Dermatology 180(6): e186. Meeting Abstract: British Society for Investigative Dermatology Annual Meeting, Bradford, UK, 01-03 Apr 2019. (doi: 10.1111/bjd.17776)

McMenemy, C. , Quinn, J.A. and Greenhalgh, D.A. (2019) Epidermal-Specific 14-3-3σ/Stratifin Overexpressioninduces Malignant Conversion of Aggressive, Rapid-growth Papillomas, but not Slower, Regression-prone Papillomas. British Journal of Dermatology 180(6): e203. Meeting Abstract: British Society for Investigative Dermatology Annual Meeting, Bradford, UK, 01-03 Apr 2019. (doi: 10.1111/bjd.17776)

Alyamani, A.M.A., Quinn, J.A. and Greenhalgh, D. A. (2018) Analysis of β-catenin expression in transgenic mouse skin carcinogenesis reveals inhibitory roles in papillomatogenesis and oncogenic roles in malignant conversion. BSID Annual Meeting 2018, London, UK, 26-28 Mar 2018.

McMenemy, C. , Quinn, J.A. and Greenhalgh, D. A. (2018) Fos co-operation with 14-3-3σ [Stratifin] induces malignant conversion in transgenic mouse skin carcinogenesis: a paradigm for SCC of follicular origin. BSID Annual Meeting 2018, London, UK, 26-28 Mar 2018.

McMenemy, C. , Guo, D., Cochrane, A., Crookston, K., Boyle, J., Quinn, J. and Greenhalgh, D. A. (2017) 14-3-3σ/Stratifin Expression in HK1.Ras/Fos-Δ5ptenflx Transgenic Mouse Skin Carcinogenesis Reveals an Early, Inhibitory Role; Lost During MDM2 Activated/P53 Inactivated Malignant Progression. British Society for Investigative Dermatology (BSID) Annual Meeting, Manchester, UK, 3-5 April 2017.

Conference Proceedings

Greenhalgh, D. , Yao, D., Quinn, J. and Macdonald, F. (2009) RasHa activation interdicts compensatory p53/p21WAF expression in Fos/PTENnull skin carcinogenesis via initial p53 loss but retention of p21WAF limits malignant progression. In: American Association for Cancer Research (AACR) 100th Annual Meeting, Denver, USA, 18-22 April 2009,

Macdonald, F., Yao, D., Quinn, J. and Greenhalgh, D. (2009) Compensatory p53/p21WAF-induced differentiation in Fos/PTENnull skin carcinogenesis is interdicted by RasHa activation but retention of p21WAF inhibits malignant progression. In: British Society for Investigative Dermatology (BSID) Annual Meeting, Royal Agricultural College, Cirencester, UK, 30 March - 1 April 2009,