Professor Kevin Ryan

  • Professor (Beatson Institute for Cancer Research)

telephone: 3655
email: Kevin.Ryan@glasgow.ac.uk

Beatson Institute, Glasgow G61 1BD

ORCID iDhttps://orcid.org/0000-0002-1059-9681

Publications

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Jump to: 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001
Number of items: 95.

2021

McEwan, D. G. and Ryan, K. (2021) ATG2 and VPS13 proteins: Molecular highways transporting lipids to drive membrane expansion and organelle communication. FEBS Journal, (doi: 10.1111/febs.16280) (Early Online Publication)

Klionsky, D. J. et al. (2021) Autophagy in major human diseases. EMBO Journal, 40(19), e108863. (doi: 10.15252/embj.2021108863) (PMID:34459017) (PMCID:PMC8488577)

Barthet, V. J.A. et al. (2021) Autophagy suppresses the formation of hepatocyte-derived cancer-initiating ductular progenitor cells in the liver. Science Advances, 7(23), eabf9141. (doi: 10.1126/sciadv.abf9141) (PMID:34088666)

Rosenfeldt, M. T., O’Prey, J., Lindsay, C. R., Nixon, C., Roth, S., Sansom, O. J. and Ryan, K. (2021) Loss of autophagy affects melanoma development in a manner dependent on PTEN status. Cell Death and Differentiation, 28(4), pp. 1437-1439. (doi: 10.1038/s41418-021-00746-7) (PMID:33664481) (PMCID:PMC8027884)

Latif, A.-L. et al. (2021) BRD4-mediated repression of p53 is a target for combination therapy in AML. Nature Communications, 12(1), 241. (doi: 10.1038/s41467-020-20378-8) (PMID:33431824) (PMCID:PMC7801601)

Klionsky, D. J. et al. (2021) Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy, 17(1), pp. 1-382. (doi: 10.1080/15548627.2020.1797280) (PMID:33634751) (PMCID:PMC7996087)

2020

Torretta, S., Scagliola, A., Ricci, L., Mainini, F., Di Marco, S., Cuccovillo, I., Kajaste-Rudnitski, A., Sumpton, D., Ryan, K. M. and Cardaci, S. (2020) D-mannose suppresses macrophage IL-1β production. Nature Communications, 11, 6343. (doi: 10.1038/s41467-020-20164-6) (PMID:33311467) (PMCID:PMC7733482)

2019

Baquero, P. et al. (2019) Targeting quiescent leukemic stem cells using second generation autophagy inhibitors. Leukemia, 33(4), pp. 981-994. (doi: 10.1038/s41375-018-0252-4) (PMID:30185934) (PMCID:PMC6292500)

Beauvarlet, J. et al. (2019) Modulation of the ATM/autophagy pathway by a G-quadruplex ligand tips the balance between senescence and apoptosis in cancer cells. Nucleic Acids Research, 47(6), pp. 2739-2756. (doi: 10.1093/nar/gkz095) (PMID:30759257) (PMCID:PMC6451122)

Beaumatin, F. et al. (2019) DRAM-1 is required for mTORC1 activation by facilitating lysosomal amino acid efflux. Molecular Cell, 76(1), 163-176.E8. (doi: 10.1016/j.molcel.2019.07.021) (PMID:31492633) (PMCID:PMC6892261)

2018

Riley, J. S. et al. (2018) Mitochondrial inner membrane permeabilisation enables mtDNA release during apoptosis. EMBO Journal, 37(17), e99238. (doi: 10.15252/embj.201899238) (PMID:30049712) (PMCID:PMC6120664)

Mitchell, R. et al. (2018) Targeting BCR-ABL independent TKI resistance in chronic myeloid leukaemia by mTOR and autophagy inhibition. Journal of the National Cancer Institute, 110(5), pp. 467-478. (doi: 10.1093/jnci/djx236) (PMID:29165716) (PMCID:PMC5946859)

Galluzzi, L. et al. (2018) Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Cell Death and Differentiation, 25(3), pp. 486-541. (doi: 10.1038/s41418-017-0012-4) (PMID:29362479) (PMCID:PMC5864239)

Campbell, K. J. et al. (2018) MCL-1 is a prognostic indicator and drug target in breast cancer. Cell Death and Disease, 9, 19. (doi: 10.1038/s41419-017-0035-2) (PMID:29339815) (PMCID:PMC5833338)

Deretic, V. et al. (2018) Autophagy, Inflammation, and Metabolism (AIM) Center of Biomedical Research Excellence: supporting the next generation of autophagy researchers and fostering international collaborations. Autophagy, 14(6), pp. 925-929. (doi: 10.1080/15548627.2018.1465784) (PMID:29938597) (PMCID:PMC6103399)

Sierra Gonzalez, P. et al. (2018) Mannose impairs tumour growth and enhances chemotherapy. Nature, 563, pp. 719-723. (doi: 10.1038/s41586-018-0729-3) (PMID:30464341)

2017

Sakamaki, J.-I., Long, J. S., New, M., Van Acker, T., Tooze, S. A. and Ryan, K. M. (2017) Emerging roles of transcriptional programs in autophagy regulation. Transcription, 9(2), pp. 131-136. (doi: 10.1080/21541264.2017.1372045) (PMID:28980873) (PMCID:PMC5834222)

Giampazolias, E. et al. (2017) Mitochondrial permeabilization engages NF-κB-dependent anti-tumour activity under caspase deficiency. Nature Cell Biology, 19(9), pp. 1116-1129. (doi: 10.1038/ncb3596) (PMID:28846096) (PMCID:PMC5624512)

Galluzzi, L. et al. (2017) Molecular definitions of autophagy and related processes. EMBO Journal, 36(13), pp. 1811-1836. (doi: 10.15252/embj.201796697) (PMID:28596378)

Rosenfeldt, M. T., O'Prey, J., Flossbach, L., Nixon, C., Morton, J. P. , Sansom, O. J. and Ryan, K. M. (2017) PTEN deficiency permits the formation of pancreatic cancer in the absence of autophagy. Cell Death and Differentiation, 24(7), pp. 1303-1304. (doi: 10.1038/cdd.2016.120) (PMID:28106883)

Simon, H.-U., Friis, R., Tait, S. W.G. and Ryan, K. M. (2017) Retrograde signaling from autophagy modulates stress responses. Science Signaling, 10(468), eaag2791. (doi: 10.1126/scisignal.aag2791) (PMID:28246201)

Sakamaki, J.-I. and Ryan, K. M. (2017) Transcriptional regulation of autophagy and lysosomal function by bromodomain protein BRD4. Autophagy, 13(11), pp. 2006-2007. (doi: 10.1080/15548627.2017.1364822) (PMID:28933601) (PMCID:PMC5788487)

2016

Patella, F., Neilson, L., Athineos, D., Erami Rud Majani, Z., Anderson, K. I., Blyth, K. , Ryan, K. and Zanivan, S. R. (2016) In-depth proteomics identifies a role for autophagy in controlling reactive oxygen species mediated endothelial permeability. Journal of Proteome Research, 15(7), pp. 2187-2197. (doi: 10.1021/acs.jproteome.6b00166) (PMID:27246970)

Sakamaki, J.-i. and Ryan, K. M. (2016) Autophagy determines the path on the TRAIL to death. Developmental Cell, 37(4), pp. 291-293. (doi: 10.1016/j.devcel.2016.05.010) (PMID:27219055)

Baudot, A. D., Crighton, D., O'Prey, J., Somers, J., Sierra Gonzalez, P. and Ryan, K. M. (2016) p53 directly regulates the glycosidase FUCA1 to promote chemotherapy-induced cell death. Cell Cycle, 15(17), pp. 2299-2308. (doi: 10.1080/15384101.2016.1191714) (PMID:27315169) (PMCID:PMC5004703)

Gillespie, D. A. and Ryan, K. M. (2016) Autophagy is critically required for DNA repair by homologous recombination. Molecular and Cellular Oncology, 3(1), e1030538. (doi: 10.1080/23723556.2015.1030538) (PMID:27308547) (PMCID:PMC4845186)

Klionsky, D. J. et al. (2016) Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy, 12(1), pp. 1-222. (doi: 10.1080/15548627.2015.1100356) (PMID:26799652) (PMCID:PMC4835977)

Mrschtik, M. and Ryan, K. M. (2016) Another DRAM involved in autophagy and cell death. Autophagy, 12(3), pp. 603-605. (doi: 10.1080/15548627.2015.1137412) (PMID:27046253) (PMCID:PMC4836028)

2015

Graczyk, D., White, R. and Ryan, K. (2015) Involvement of RNA polymerase III in immune responses. Molecular and Cellular Biology, 35(10), pp. 1848-1859. (doi: 10.1128/MCB.00990-14) (PMID:25776554)

Mrschtik, M. and Ryan, K. M. (2015) Lysosomal proteins in cell death and autophagy. FEBS Journal, 282(10), pp. 1858-1870. (doi: 10.1111/febs.13253) (PMID:25735653)

Baudot, A., Haller, M., Mrschtik, M., Tait, S. and Ryan, K. (2015) Using enhanced-mitophagy to measure autophagic flux. Methods, 75, pp. 105-111. (doi: 10.1016/j.ymeth.2014.11.014) (PMID:25498004) (PMCID:PMC4358839)

Liu, E. Y. et al. (2015) Loss of autophagy causes a synthetic lethal deficiency in DNA repair. Proceedings of the National Academy of Sciences of the United States of America, 112(3), pp. 773-778. (doi: 10.1073/pnas.1409563112)

Galluzzi, L. et al. (2015) Autophagy in malignant transformation and cancer progression. EMBO Journal, 34(7), pp. 856-880. (doi: 10.15252/embj.201490784) (PMID:25712477) (PMCID:PMC4388596)

Long, J.S., Schoonen, P.M., Graczyk, D., O'Prey, J. and Ryan, K. (2015) p73 engages A2B receptor signalling to prime cancer cells to chemotherapy-induced death. Oncogene, 34(40), pp. 5152-5162. (doi: 10.1038/onc.2014.436) (PMID:25659586)

Mrschtik, M., O'Prey, J., Lao, L.Y., Long, J.S., Beaumatin, F., Strachan, D., O'Prey, M., Skommer, J. and Ryan, K.M. (2015) DRAM-3 modulates autophagy and promotes cell survival in the absence of glucose. Cell Death and Differentiation, 22(10), pp. 1714-1726. (doi: 10.1038/cdd.2015.26) (PMID:25929859) (PMCID:PMC4563785)

2014

Joshi, S. and Ryan, K.M. (2014) Autophagy chews Fap to promote apoptosis. Nature Cell Biology, 16(1), pp. 23-25. (doi: 10.1038/ncb2899)

Haller, M., Hock, A. K., Giampazolias, E., Oberst, A., Green, D. R., Debnath, J., Ryan, K. M. , Vousden, K. H. and Tait, S. W. G. (2014) Ubiquitination and proteasomal degradation of ATG12 regulates its proapoptotic activity. Autophagy, 10(12), pp. 2269-2278. (doi: 10.4161/15548627.2014.981914) (PMID:25629932) (PMCID:PMC4502749)

Rosenfeldt, M.T., Bell, L.A., Long, J.S., O'Prey, J., Nixon, C., Roberts, F., Dufès, C. and Ryan, K.M. (2014) E2F1 drives chemotherapeutic drug resistance via ABCG2. Oncogene, 33(32), pp. 4164-4172. (doi: 10.1038/onc.2013.470)

2013

Macintosh, R.L. and Ryan, K.M. (2013) Autophagy in tumour cell death. Seminars in Cancer Biology, 23(5), pp. 344-351. (doi: 10.1016/j.semcancer.2013.05.006)

Long, J.S., Crighton, D., O’Prey, J., MacKay, G., Zheng, L., Palmer, T.M., Gottlieb, E. and Ryan, K.M. (2013) Extracellular adenosine sensing—a metabolic cell death priming mechanism downstream of p53. Molecular Cell, 50(3), pp. 394-406. (doi: 10.1016/j.molcel.2013.03.016)

Bennett, H.L., Stockley, J., Fleming, J.T., Mandal, R., O'Prey, J., Ryan, K.M. , Robson, C.N. and Leung, H.Y. (2013) Does androgen-ablation therapy (AAT) associated autophagy have a pro-survival effect in LNCaP human prostate cancer cells? BJU International, 111(4), pp. 672-682. (doi: 10.1111/j.1464-410X.2012.11409.x)

Laine, A. et al. (2013) Senescence sensitivity of breast cancer cells is defined by positive feedback loop between CIP2A and E2F1. Cancer Discovery, 3(2), pp. 182-197. (doi: 10.1158/2159-8290.CD-12-0292)

Helgason, G.V. , Holyoake, T.L. and Ryan, K.M. (2013) Role of autophagy in cancer prevention, development and therapy. Essays in Biochemistry, 55(1), pp. 133-151. (doi: 10.1042/BSE0550133)

Ramirez-Peinado, S., Leon-Annicchiarico, C. L., Galindo-Moreno, J., Iurlaro, R., Caro-Maldonado, A., Prehn, J. H.M., Ryan, K. M. and Munoz-Pinedo, C. (2013) Glucose-starved cells do not engage in prosurvival autophagy. Journal of Biological Chemistry, 288(42), pp. 30387-30398. (doi: 10.1074/jbc.M113.490581)

Rosenfeldt, M.T. et al. (2013) p53 status determines the role of autophagy in pancreatic tumour development. Nature, 504(7479), pp. 296-300. (doi: 10.1038/nature12865)

2012

Klionsky, D. J. et al. (2012) Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy, 8(4), pp. 445-544. (doi: 10.4161/auto.19496) (PMID:22966490) (PMCID:PMC3404883)

Liu, E.Y. and Ryan, K.M. (2012) Autophagy and cancer - issues we need to digest. Journal of Cell Science, 125(10), pp. 2349-2358.

Ladoire, S. et al. (2012) Immunohistochemical detection of cytoplasmic LC3 puncta in human cancer specimens. Autophagy, 8(8), pp. 1175-1184. (doi: 10.4161/auto.20353)

Lemarié, F., Croft, D.R., Tate, R.J., Ryan, K.M. and Dufès, C. (2012) Tumor regression following intravenous administration of a tumor-targeted p73 gene delivery system. Biomaterials, 33(9), pp. 2701-2709. (doi: 10.1016/j.biomaterials.2011.12.019)

Long, J.S. and Ryan, K.M. (2012) New frontiers in promoting tumour cell death: targeting apoptosis, necroptosis and autophagy. Oncogene, 31(49), pp. 5045-5060. (doi: 10.1038/onc.2012.7)

Mah, L.Y. and Ryan, K.M. (2012) Autophagy and cancer. Cold Spring Harbor Perspectives in Biology, 4(1), a008821-a008821. (doi: 10.1101/cshperspect.a008821)

2011

Croft, D.R. et al. (2011) p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival. Cell Research, 21(4), pp. 666-682. (doi: 10.1038/cr.2010.154)

Baudot, A.D. and Ryan, K.M. (2011) p53 and tumor surveillance: killer finds way to recruit assassins. Cell Cycle, 10(22), p. 3818. (doi: 10.4161/cc.10.22.18191)

Rosenfeldt, M.T. and Ryan, K.M. (2011) The multiple roles of autophagy in cancer. Carcinogenesis, 32(7), pp. 955-963. (doi: 10.1093/carcin/bgr031)

Ryan, K.M. (2011) p53 and autophagy in cancer: Guardian of the genome meets guardian of the proteome. European Journal of Cancer, 47(1), pp. 44-50. (doi: 10.1016/j.ejca.2010.10.020)

Stindt, M.H., Carter, S., Vigneron, A.M., Ryan, K.M. and Vousden, K.H. (2011) MDM2 promotes SUMO-2/3 modification of p53 to modulate transcriptional activity. Cell Cycle, 10(18), pp. 3176-3188. (doi: 10.4161/cc.10.18.17436)

Wilkinson, S., Croft, D.R., O’Prey, J., Meedendorp, A., O’Prey, M., Dufès, C. and Ryan, K.M. (2011) The cyclin-dependent kinase PITSLRE/CDK11 is required for successful autophagy. Autophagy, 7(11), pp. 1295-1301. (doi: 10.4161/auto.7.11.16646)

2010

Long, J.S. and Ryan, K.M. (2010) p53 and senescence: a little goes a long way. Cell Cycle, 9(20), pp. 4050-4051. (doi: 10.4161/cc.9.20.13747)

Bennett, H.L., Fleming, J.T., O'Prey, J., Ryan, K.M. and Leung, H.Y. (2010) Androgens modulate autophagy and cell death via regulation of the endoplasmic reticulum chaperone glucose-regulated protein 78/BiP in prostate cancer cells. Cell Death and Disease, 1(9), e72. (doi: 10.1038/cddis.2010.50)

Fricker, M., O'Prey, J., Tolkovsky, A.M. and Ryan, K.M. (2010) Phosphorylation of Puma modulates its apoptotic function by regulating protein stability. Cell Death and Disease, 1(7), e59. (doi: 10.1038/cddis.2010.38)

Helgason, G.V. , O'Prey, J. and Ryan, K.M. (2010) Oncogene-induced sensitization to chemotherapy-induced death requires induction as well as deregulation of E2F1. Cancer Research, 70(10), pp. 4074-4080. (doi: 10.1158/0008-5472.CAN-09-2876)

Huser, C.A., Pringle, M.A., Heath, V.J., Bell, A.K., Kendrick, H., Smalley, M.J., Crighton, D., Ryan, K.M., Gusterson, B.A. and Stein, T. (2010) TSC-22D1 isoforms have opposing roles in mammary epithelial cell survival. Cell Death and Differentiation, 17(2), pp. 304-315. (doi: 10.1038/cdd.2009.126)

Lorin, S., Pierron, G., Ryan, K.M. , Codogno, P. and Djavaheri-Mergny, M. (2010) Evidence for the interplay between JNK and p53-DRAM signaling pathways in the regulation of autophagy. Autophagy, 6(1), pp. 153-154. (doi: 10.4161/auto.6.1.10537)

O'Prey, J., Crighton, D., Martin, A., Vousden, K., Fearnhead, H. and Ryan, K. (2010) p53-mediated induction of Noxa and p53AIP1 requires NF kappa B. Cell Cycle, 9(5), pp. 947-952.

Ryan, K.M. (2010) Cancer: Viruses' backup plan. Nature, 466(7310), pp. 1054-1055. (doi: 10.1038/4661054a)

Wilkinson, S. and Ryan, K.M. (2010) Autophagy: an adaptable modifier of tumourigenesis. Current Opinion in Genetics and Development, 20(1), pp. 57-64. (doi: 10.1016/j.gde.2009.12.004)

2009

Lorin, S., Borges, A., Ribeiro Dos Santos, L., Souquere, S., Pierron, G., Ryan, K.M. , Codogno, P. and Djavaheri-Mergny, M. (2009) c-Jun NH2-Terminal Kinase Activation Is Essential for DRAM-Dependent Induction of Autophagy and Apoptosis in 2-Methoxyestradiol-Treated Ewing Sarcoma Cells. Cancer Research, 69(17), pp. 6924-6931. (doi: 10.1158/0008-5472.CAN-09-1270)

Martin, A.G., Trama, J., Crighton, D., Ryan, K.M. and Fearnhead, H.O. (2009) Activation of p73 and induction of Noxa by DNA damage requires NF-kappa B. Aging, 1(3), pp. 335-349.

O'Prey, J., Skommer, J., Wilkinson, S. and Ryan, K.M. (2009) Analysis of DRAM-related proteins reveals evolutionarily conserved and divergent roles in the control of autophagy. Cell Cycle, 8(14), pp. 2260-2265. (doi: 10.4161/cc.8.14.9050)

Rosenfeldt, M.T. and Ryan, K.M. (2009) The role of autophagy in tumour development and cancer therapy. Expert Reviews in Molecular Medicine, 11, e36. (doi: 10.1017/S1462399409001306)

Vousden, K. and Ryan, K. (2009) p53 and metabolism. Nature Reviews Cancer, 9(10), pp. 691-700. (doi: 10.1038/nrc2715)

Wilkinson, S., O'Prey, J., Fricker, M. and Ryan, K.M. (2009) Hypoxia-selective macroautophagy and cell survival signaled by autocrine PDGFR activity. Genes and Development, 23(11), pp. 1283-1288. (doi: 10.1101/gad.521709)

Wilkinson, S. and Ryan, K.M. (2009) Growth factor signaling permits hypoxia-induced autophagy by a HIF1 alpha-dependent, BNIP3/3L-independent transcriptional program in human cancer cells. Autophagy, 5(7), pp. 1068-1069.

Yee, K., Wilkinson, S., James, J., Ryan, K. and Vousden, K. (2009) PUMA- and Bax-induced autophagy contributes to apoptosis. Cell Death and Differentiation, 16(8), pp. 1135-1145. (doi: 10.1038/cdd.2009.28)

2008

Huser, C. , Heath, V., Pringle, M.-A. , Bell, A.K., Crighton, D., Ryan, K. , Inman, G. , Stein, T. and Gusterson, B. (2008) TSC22 in Mammary Gland Development and Breast Cancer. Breast Cancer Research 2008, London, UK, 13 May 2008. (doi: 10.1186/bcr1901)

Bell, H. and Ryan, K. (2008) iASPP inhibition: Increased options in targeting the p53 family for cancer therapy. Cancer Research, 68(13), pp. 4959-4962. (doi: 10.1158/0008-5472.CAN-08-0182)

O'Prey, J., Wilkinson, S. and Ryan, K.M. (2008) Tumor Antigen LRRC15 Impedes Adenoviral Infection: Implications for Virus-Based Cancer Therapy. Journal of Virology, 82(12), pp. 5933-5939. (doi: 10.1128/JVI.02273-07)

Park, M. et al. (2008) Vorinostat and sorafenib increase ER stress, autophagy and apoptosis via ceramide-dependent CD95 and PERK activation. Cancer Biology and Therapy, 7(10), pp. 1648-1662.

2007

Bell, H., Dufes, C., O'Prey, J., Crighton, D., Bergamaschi, D., Lu, X., Schatzlein, A., Vousden, K. and Ryan, K. (2007) A p53-derived apoptotic peptide derepresses p73 to cause tumor regression in vivo. Journal of Clinical Investigation, 117, pp. 1008-1018. (doi: 10.1172/JCI28920)

Bell, H. and Ryan, K. (2007) Targeting the p53 family for cancer therapy - 'Big brother' joins the fight. Cell Cycle, 6(16), pp. 1995-2000. (doi: 10.4161/cc.6.16.4614)

Crighton, D., Wilkinson, S. and Ryan, K. (2007) DRAM links autophagy to p53 and programmed cell death. Autophagy, 3(1), pp. 72-74.

Crighton, D., O'Prey, J., Bell, H.S. and Ryan, K.M. (2007) p73 regulates DRAM-independent autophagy that does not contribute to programmed cell death. Cell Death and Differentiation, 14(6), pp. 1071-1079. (doi: 10.1038/sj.cdd.4402108)

Ewings, K.E. and Ryan, K.M. (2007) Hzf and hCAS/CSE1L: making the right choice in p53-mediated tumour suppression. Cell Research, 17(10), pp. 829-831. (doi: 10.1038/cr.2007.85)

2006

Bell, L.A., O'Prey, J. and Ryan, K.M. (2006) DNA-binding independent cell death from a minimal proapoptotic region of E2F-1. Oncogene, 25(41), pp. 5656-5663. (doi: 10.1038/sj.onc.1209580)

Crighton, D., Wilkinson, S., O'Prey, J., Syed, N., Smith, P., Harrison, P.R., Gasco, M., Garrone, O., Crook, T. and Ryan, K. (2006) DRAM, a p53-induced modulator of autophagy, is critical for apoptosis. Cell, 126(1), pp. 121-134. (doi: 10.1016/j.cell.2006.05.034)

2005

Bell, H. and Ryan, K. (2005) Intracellular signalling and cancer: complex pathways lead to multiple targets. European Journal of Cancer, 41(2), pp. 206-215. (doi: 10.1016/j.ejca.2004.10.022)

2004

Bell, L. and Ryan, K. (2004) Life and death decisions by E2F-1. Cell Death and Differentiation, 11(2), pp. 137-142. (doi: 10.1038/sj.cdd.4401324)

Crighton, D. and Ryan, K.M. (2004) Splicing DNA-damage responses to turnour cell death. Biochimica et Biophysica Acta: Reviews on Cancer, 1705(1), pp. 3-15. (doi: 10.1016/j.bbcan.2004.09.001)

Ryan, K. , O'Prey, J. and Vousden, K. (2004) Loss of nuclear factor-KB is tumor promoting but does not substitute for loss of p53. Cancer Research, 64(13), pp. 4415-4418. (doi: 10.1158/0008-5472.CAN-04-1474)

Wang, W., Cassidy, J., O'Brien, V., Ryan, K. and Collie-Duguid, E. (2004) Mechanistic and Predictive Profiling of 5-Fluorouracil Resistance in Human Cancer Cells. Cancer Research, 64(22), pp. 8167-8176. (doi: 10.1158/0008-5472.CAN-04-0970)

2003

Gorgoulis, V.G., Zacharatos, P., Kotsinas, A., Kletsas, D., Mariatos, G., Zoumpourlis, V., Ryan, K.M. , Kittas, C. and Papavassiliou, A.G. (2003) p53 activates ICAM-1 (CD54) expression in an NF-kappaB-independent manner. EMBO Journal, 22(7), pp. 1567-1578. (doi: 10.1093/emboj/cdg157)

2002

Ryan, K. and Vousden, K. (2002) Cancer: Pinning a change on p53. Nature, 419(6909), pp. 795-797. (doi: 10.1038/419795a)

2001

Baird, J. et al. (2001) Differentiating embryonal stem cells are a rich source of haemopoietic gene products and suggest erythroid preconditioning of primitive haemopoietic stem cells. Journal of Biological Chemistry, 276(12), pp. 9189-9198. (doi: 10.1074/jbc.M008354200)

Blagosklonny, M., Giannakakou, P., Romanova, L., Ryan, K. , Vousden, K. and Fojo, T. (2001) Inhibition of HIF-1-and wild-type p53-stimulated transcription by codon Arg175 p53 mutants with selective loss of functions. Carcinogenesis, 22(6), pp. 861-867. (doi: 10.1093/carcin/22.6.861)

Ryan, K. , Phillips, A. and Vousden, K. (2001) Regulation and function of the p53 tumor suppressor protein. Current Opinion in Cell Biology, 13(3), pp. 332-337. (doi: 10.1016/S0955-0674(00)00216-7)

This list was generated on Tue Nov 30 14:23:51 2021 GMT.
Number of items: 95.

Articles

McEwan, D. G. and Ryan, K. (2021) ATG2 and VPS13 proteins: Molecular highways transporting lipids to drive membrane expansion and organelle communication. FEBS Journal, (doi: 10.1111/febs.16280) (Early Online Publication)

Klionsky, D. J. et al. (2021) Autophagy in major human diseases. EMBO Journal, 40(19), e108863. (doi: 10.15252/embj.2021108863) (PMID:34459017) (PMCID:PMC8488577)

Barthet, V. J.A. et al. (2021) Autophagy suppresses the formation of hepatocyte-derived cancer-initiating ductular progenitor cells in the liver. Science Advances, 7(23), eabf9141. (doi: 10.1126/sciadv.abf9141) (PMID:34088666)

Rosenfeldt, M. T., O’Prey, J., Lindsay, C. R., Nixon, C., Roth, S., Sansom, O. J. and Ryan, K. (2021) Loss of autophagy affects melanoma development in a manner dependent on PTEN status. Cell Death and Differentiation, 28(4), pp. 1437-1439. (doi: 10.1038/s41418-021-00746-7) (PMID:33664481) (PMCID:PMC8027884)

Latif, A.-L. et al. (2021) BRD4-mediated repression of p53 is a target for combination therapy in AML. Nature Communications, 12(1), 241. (doi: 10.1038/s41467-020-20378-8) (PMID:33431824) (PMCID:PMC7801601)

Klionsky, D. J. et al. (2021) Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy, 17(1), pp. 1-382. (doi: 10.1080/15548627.2020.1797280) (PMID:33634751) (PMCID:PMC7996087)

Torretta, S., Scagliola, A., Ricci, L., Mainini, F., Di Marco, S., Cuccovillo, I., Kajaste-Rudnitski, A., Sumpton, D., Ryan, K. M. and Cardaci, S. (2020) D-mannose suppresses macrophage IL-1β production. Nature Communications, 11, 6343. (doi: 10.1038/s41467-020-20164-6) (PMID:33311467) (PMCID:PMC7733482)

Baquero, P. et al. (2019) Targeting quiescent leukemic stem cells using second generation autophagy inhibitors. Leukemia, 33(4), pp. 981-994. (doi: 10.1038/s41375-018-0252-4) (PMID:30185934) (PMCID:PMC6292500)

Beauvarlet, J. et al. (2019) Modulation of the ATM/autophagy pathway by a G-quadruplex ligand tips the balance between senescence and apoptosis in cancer cells. Nucleic Acids Research, 47(6), pp. 2739-2756. (doi: 10.1093/nar/gkz095) (PMID:30759257) (PMCID:PMC6451122)

Beaumatin, F. et al. (2019) DRAM-1 is required for mTORC1 activation by facilitating lysosomal amino acid efflux. Molecular Cell, 76(1), 163-176.E8. (doi: 10.1016/j.molcel.2019.07.021) (PMID:31492633) (PMCID:PMC6892261)

Riley, J. S. et al. (2018) Mitochondrial inner membrane permeabilisation enables mtDNA release during apoptosis. EMBO Journal, 37(17), e99238. (doi: 10.15252/embj.201899238) (PMID:30049712) (PMCID:PMC6120664)

Mitchell, R. et al. (2018) Targeting BCR-ABL independent TKI resistance in chronic myeloid leukaemia by mTOR and autophagy inhibition. Journal of the National Cancer Institute, 110(5), pp. 467-478. (doi: 10.1093/jnci/djx236) (PMID:29165716) (PMCID:PMC5946859)

Galluzzi, L. et al. (2018) Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Cell Death and Differentiation, 25(3), pp. 486-541. (doi: 10.1038/s41418-017-0012-4) (PMID:29362479) (PMCID:PMC5864239)

Campbell, K. J. et al. (2018) MCL-1 is a prognostic indicator and drug target in breast cancer. Cell Death and Disease, 9, 19. (doi: 10.1038/s41419-017-0035-2) (PMID:29339815) (PMCID:PMC5833338)

Deretic, V. et al. (2018) Autophagy, Inflammation, and Metabolism (AIM) Center of Biomedical Research Excellence: supporting the next generation of autophagy researchers and fostering international collaborations. Autophagy, 14(6), pp. 925-929. (doi: 10.1080/15548627.2018.1465784) (PMID:29938597) (PMCID:PMC6103399)

Sierra Gonzalez, P. et al. (2018) Mannose impairs tumour growth and enhances chemotherapy. Nature, 563, pp. 719-723. (doi: 10.1038/s41586-018-0729-3) (PMID:30464341)

Sakamaki, J.-I., Long, J. S., New, M., Van Acker, T., Tooze, S. A. and Ryan, K. M. (2017) Emerging roles of transcriptional programs in autophagy regulation. Transcription, 9(2), pp. 131-136. (doi: 10.1080/21541264.2017.1372045) (PMID:28980873) (PMCID:PMC5834222)

Giampazolias, E. et al. (2017) Mitochondrial permeabilization engages NF-κB-dependent anti-tumour activity under caspase deficiency. Nature Cell Biology, 19(9), pp. 1116-1129. (doi: 10.1038/ncb3596) (PMID:28846096) (PMCID:PMC5624512)

Galluzzi, L. et al. (2017) Molecular definitions of autophagy and related processes. EMBO Journal, 36(13), pp. 1811-1836. (doi: 10.15252/embj.201796697) (PMID:28596378)

Rosenfeldt, M. T., O'Prey, J., Flossbach, L., Nixon, C., Morton, J. P. , Sansom, O. J. and Ryan, K. M. (2017) PTEN deficiency permits the formation of pancreatic cancer in the absence of autophagy. Cell Death and Differentiation, 24(7), pp. 1303-1304. (doi: 10.1038/cdd.2016.120) (PMID:28106883)

Simon, H.-U., Friis, R., Tait, S. W.G. and Ryan, K. M. (2017) Retrograde signaling from autophagy modulates stress responses. Science Signaling, 10(468), eaag2791. (doi: 10.1126/scisignal.aag2791) (PMID:28246201)

Sakamaki, J.-I. and Ryan, K. M. (2017) Transcriptional regulation of autophagy and lysosomal function by bromodomain protein BRD4. Autophagy, 13(11), pp. 2006-2007. (doi: 10.1080/15548627.2017.1364822) (PMID:28933601) (PMCID:PMC5788487)

Patella, F., Neilson, L., Athineos, D., Erami Rud Majani, Z., Anderson, K. I., Blyth, K. , Ryan, K. and Zanivan, S. R. (2016) In-depth proteomics identifies a role for autophagy in controlling reactive oxygen species mediated endothelial permeability. Journal of Proteome Research, 15(7), pp. 2187-2197. (doi: 10.1021/acs.jproteome.6b00166) (PMID:27246970)

Sakamaki, J.-i. and Ryan, K. M. (2016) Autophagy determines the path on the TRAIL to death. Developmental Cell, 37(4), pp. 291-293. (doi: 10.1016/j.devcel.2016.05.010) (PMID:27219055)

Baudot, A. D., Crighton, D., O'Prey, J., Somers, J., Sierra Gonzalez, P. and Ryan, K. M. (2016) p53 directly regulates the glycosidase FUCA1 to promote chemotherapy-induced cell death. Cell Cycle, 15(17), pp. 2299-2308. (doi: 10.1080/15384101.2016.1191714) (PMID:27315169) (PMCID:PMC5004703)

Gillespie, D. A. and Ryan, K. M. (2016) Autophagy is critically required for DNA repair by homologous recombination. Molecular and Cellular Oncology, 3(1), e1030538. (doi: 10.1080/23723556.2015.1030538) (PMID:27308547) (PMCID:PMC4845186)

Klionsky, D. J. et al. (2016) Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy, 12(1), pp. 1-222. (doi: 10.1080/15548627.2015.1100356) (PMID:26799652) (PMCID:PMC4835977)

Mrschtik, M. and Ryan, K. M. (2016) Another DRAM involved in autophagy and cell death. Autophagy, 12(3), pp. 603-605. (doi: 10.1080/15548627.2015.1137412) (PMID:27046253) (PMCID:PMC4836028)

Graczyk, D., White, R. and Ryan, K. (2015) Involvement of RNA polymerase III in immune responses. Molecular and Cellular Biology, 35(10), pp. 1848-1859. (doi: 10.1128/MCB.00990-14) (PMID:25776554)

Mrschtik, M. and Ryan, K. M. (2015) Lysosomal proteins in cell death and autophagy. FEBS Journal, 282(10), pp. 1858-1870. (doi: 10.1111/febs.13253) (PMID:25735653)

Baudot, A., Haller, M., Mrschtik, M., Tait, S. and Ryan, K. (2015) Using enhanced-mitophagy to measure autophagic flux. Methods, 75, pp. 105-111. (doi: 10.1016/j.ymeth.2014.11.014) (PMID:25498004) (PMCID:PMC4358839)

Liu, E. Y. et al. (2015) Loss of autophagy causes a synthetic lethal deficiency in DNA repair. Proceedings of the National Academy of Sciences of the United States of America, 112(3), pp. 773-778. (doi: 10.1073/pnas.1409563112)

Galluzzi, L. et al. (2015) Autophagy in malignant transformation and cancer progression. EMBO Journal, 34(7), pp. 856-880. (doi: 10.15252/embj.201490784) (PMID:25712477) (PMCID:PMC4388596)

Long, J.S., Schoonen, P.M., Graczyk, D., O'Prey, J. and Ryan, K. (2015) p73 engages A2B receptor signalling to prime cancer cells to chemotherapy-induced death. Oncogene, 34(40), pp. 5152-5162. (doi: 10.1038/onc.2014.436) (PMID:25659586)

Mrschtik, M., O'Prey, J., Lao, L.Y., Long, J.S., Beaumatin, F., Strachan, D., O'Prey, M., Skommer, J. and Ryan, K.M. (2015) DRAM-3 modulates autophagy and promotes cell survival in the absence of glucose. Cell Death and Differentiation, 22(10), pp. 1714-1726. (doi: 10.1038/cdd.2015.26) (PMID:25929859) (PMCID:PMC4563785)

Joshi, S. and Ryan, K.M. (2014) Autophagy chews Fap to promote apoptosis. Nature Cell Biology, 16(1), pp. 23-25. (doi: 10.1038/ncb2899)

Haller, M., Hock, A. K., Giampazolias, E., Oberst, A., Green, D. R., Debnath, J., Ryan, K. M. , Vousden, K. H. and Tait, S. W. G. (2014) Ubiquitination and proteasomal degradation of ATG12 regulates its proapoptotic activity. Autophagy, 10(12), pp. 2269-2278. (doi: 10.4161/15548627.2014.981914) (PMID:25629932) (PMCID:PMC4502749)

Rosenfeldt, M.T., Bell, L.A., Long, J.S., O'Prey, J., Nixon, C., Roberts, F., Dufès, C. and Ryan, K.M. (2014) E2F1 drives chemotherapeutic drug resistance via ABCG2. Oncogene, 33(32), pp. 4164-4172. (doi: 10.1038/onc.2013.470)

Macintosh, R.L. and Ryan, K.M. (2013) Autophagy in tumour cell death. Seminars in Cancer Biology, 23(5), pp. 344-351. (doi: 10.1016/j.semcancer.2013.05.006)

Long, J.S., Crighton, D., O’Prey, J., MacKay, G., Zheng, L., Palmer, T.M., Gottlieb, E. and Ryan, K.M. (2013) Extracellular adenosine sensing—a metabolic cell death priming mechanism downstream of p53. Molecular Cell, 50(3), pp. 394-406. (doi: 10.1016/j.molcel.2013.03.016)

Bennett, H.L., Stockley, J., Fleming, J.T., Mandal, R., O'Prey, J., Ryan, K.M. , Robson, C.N. and Leung, H.Y. (2013) Does androgen-ablation therapy (AAT) associated autophagy have a pro-survival effect in LNCaP human prostate cancer cells? BJU International, 111(4), pp. 672-682. (doi: 10.1111/j.1464-410X.2012.11409.x)

Laine, A. et al. (2013) Senescence sensitivity of breast cancer cells is defined by positive feedback loop between CIP2A and E2F1. Cancer Discovery, 3(2), pp. 182-197. (doi: 10.1158/2159-8290.CD-12-0292)

Helgason, G.V. , Holyoake, T.L. and Ryan, K.M. (2013) Role of autophagy in cancer prevention, development and therapy. Essays in Biochemistry, 55(1), pp. 133-151. (doi: 10.1042/BSE0550133)

Ramirez-Peinado, S., Leon-Annicchiarico, C. L., Galindo-Moreno, J., Iurlaro, R., Caro-Maldonado, A., Prehn, J. H.M., Ryan, K. M. and Munoz-Pinedo, C. (2013) Glucose-starved cells do not engage in prosurvival autophagy. Journal of Biological Chemistry, 288(42), pp. 30387-30398. (doi: 10.1074/jbc.M113.490581)

Rosenfeldt, M.T. et al. (2013) p53 status determines the role of autophagy in pancreatic tumour development. Nature, 504(7479), pp. 296-300. (doi: 10.1038/nature12865)

Klionsky, D. J. et al. (2012) Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy, 8(4), pp. 445-544. (doi: 10.4161/auto.19496) (PMID:22966490) (PMCID:PMC3404883)

Liu, E.Y. and Ryan, K.M. (2012) Autophagy and cancer - issues we need to digest. Journal of Cell Science, 125(10), pp. 2349-2358.

Ladoire, S. et al. (2012) Immunohistochemical detection of cytoplasmic LC3 puncta in human cancer specimens. Autophagy, 8(8), pp. 1175-1184. (doi: 10.4161/auto.20353)

Lemarié, F., Croft, D.R., Tate, R.J., Ryan, K.M. and Dufès, C. (2012) Tumor regression following intravenous administration of a tumor-targeted p73 gene delivery system. Biomaterials, 33(9), pp. 2701-2709. (doi: 10.1016/j.biomaterials.2011.12.019)

Long, J.S. and Ryan, K.M. (2012) New frontiers in promoting tumour cell death: targeting apoptosis, necroptosis and autophagy. Oncogene, 31(49), pp. 5045-5060. (doi: 10.1038/onc.2012.7)

Mah, L.Y. and Ryan, K.M. (2012) Autophagy and cancer. Cold Spring Harbor Perspectives in Biology, 4(1), a008821-a008821. (doi: 10.1101/cshperspect.a008821)

Croft, D.R. et al. (2011) p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival. Cell Research, 21(4), pp. 666-682. (doi: 10.1038/cr.2010.154)

Baudot, A.D. and Ryan, K.M. (2011) p53 and tumor surveillance: killer finds way to recruit assassins. Cell Cycle, 10(22), p. 3818. (doi: 10.4161/cc.10.22.18191)

Rosenfeldt, M.T. and Ryan, K.M. (2011) The multiple roles of autophagy in cancer. Carcinogenesis, 32(7), pp. 955-963. (doi: 10.1093/carcin/bgr031)

Ryan, K.M. (2011) p53 and autophagy in cancer: Guardian of the genome meets guardian of the proteome. European Journal of Cancer, 47(1), pp. 44-50. (doi: 10.1016/j.ejca.2010.10.020)

Stindt, M.H., Carter, S., Vigneron, A.M., Ryan, K.M. and Vousden, K.H. (2011) MDM2 promotes SUMO-2/3 modification of p53 to modulate transcriptional activity. Cell Cycle, 10(18), pp. 3176-3188. (doi: 10.4161/cc.10.18.17436)

Wilkinson, S., Croft, D.R., O’Prey, J., Meedendorp, A., O’Prey, M., Dufès, C. and Ryan, K.M. (2011) The cyclin-dependent kinase PITSLRE/CDK11 is required for successful autophagy. Autophagy, 7(11), pp. 1295-1301. (doi: 10.4161/auto.7.11.16646)

Long, J.S. and Ryan, K.M. (2010) p53 and senescence: a little goes a long way. Cell Cycle, 9(20), pp. 4050-4051. (doi: 10.4161/cc.9.20.13747)

Bennett, H.L., Fleming, J.T., O'Prey, J., Ryan, K.M. and Leung, H.Y. (2010) Androgens modulate autophagy and cell death via regulation of the endoplasmic reticulum chaperone glucose-regulated protein 78/BiP in prostate cancer cells. Cell Death and Disease, 1(9), e72. (doi: 10.1038/cddis.2010.50)

Fricker, M., O'Prey, J., Tolkovsky, A.M. and Ryan, K.M. (2010) Phosphorylation of Puma modulates its apoptotic function by regulating protein stability. Cell Death and Disease, 1(7), e59. (doi: 10.1038/cddis.2010.38)

Helgason, G.V. , O'Prey, J. and Ryan, K.M. (2010) Oncogene-induced sensitization to chemotherapy-induced death requires induction as well as deregulation of E2F1. Cancer Research, 70(10), pp. 4074-4080. (doi: 10.1158/0008-5472.CAN-09-2876)

Huser, C.A., Pringle, M.A., Heath, V.J., Bell, A.K., Kendrick, H., Smalley, M.J., Crighton, D., Ryan, K.M., Gusterson, B.A. and Stein, T. (2010) TSC-22D1 isoforms have opposing roles in mammary epithelial cell survival. Cell Death and Differentiation, 17(2), pp. 304-315. (doi: 10.1038/cdd.2009.126)

Lorin, S., Pierron, G., Ryan, K.M. , Codogno, P. and Djavaheri-Mergny, M. (2010) Evidence for the interplay between JNK and p53-DRAM signaling pathways in the regulation of autophagy. Autophagy, 6(1), pp. 153-154. (doi: 10.4161/auto.6.1.10537)

O'Prey, J., Crighton, D., Martin, A., Vousden, K., Fearnhead, H. and Ryan, K. (2010) p53-mediated induction of Noxa and p53AIP1 requires NF kappa B. Cell Cycle, 9(5), pp. 947-952.

Ryan, K.M. (2010) Cancer: Viruses' backup plan. Nature, 466(7310), pp. 1054-1055. (doi: 10.1038/4661054a)

Wilkinson, S. and Ryan, K.M. (2010) Autophagy: an adaptable modifier of tumourigenesis. Current Opinion in Genetics and Development, 20(1), pp. 57-64. (doi: 10.1016/j.gde.2009.12.004)

Lorin, S., Borges, A., Ribeiro Dos Santos, L., Souquere, S., Pierron, G., Ryan, K.M. , Codogno, P. and Djavaheri-Mergny, M. (2009) c-Jun NH2-Terminal Kinase Activation Is Essential for DRAM-Dependent Induction of Autophagy and Apoptosis in 2-Methoxyestradiol-Treated Ewing Sarcoma Cells. Cancer Research, 69(17), pp. 6924-6931. (doi: 10.1158/0008-5472.CAN-09-1270)

Martin, A.G., Trama, J., Crighton, D., Ryan, K.M. and Fearnhead, H.O. (2009) Activation of p73 and induction of Noxa by DNA damage requires NF-kappa B. Aging, 1(3), pp. 335-349.

O'Prey, J., Skommer, J., Wilkinson, S. and Ryan, K.M. (2009) Analysis of DRAM-related proteins reveals evolutionarily conserved and divergent roles in the control of autophagy. Cell Cycle, 8(14), pp. 2260-2265. (doi: 10.4161/cc.8.14.9050)

Rosenfeldt, M.T. and Ryan, K.M. (2009) The role of autophagy in tumour development and cancer therapy. Expert Reviews in Molecular Medicine, 11, e36. (doi: 10.1017/S1462399409001306)

Vousden, K. and Ryan, K. (2009) p53 and metabolism. Nature Reviews Cancer, 9(10), pp. 691-700. (doi: 10.1038/nrc2715)

Wilkinson, S., O'Prey, J., Fricker, M. and Ryan, K.M. (2009) Hypoxia-selective macroautophagy and cell survival signaled by autocrine PDGFR activity. Genes and Development, 23(11), pp. 1283-1288. (doi: 10.1101/gad.521709)

Wilkinson, S. and Ryan, K.M. (2009) Growth factor signaling permits hypoxia-induced autophagy by a HIF1 alpha-dependent, BNIP3/3L-independent transcriptional program in human cancer cells. Autophagy, 5(7), pp. 1068-1069.

Yee, K., Wilkinson, S., James, J., Ryan, K. and Vousden, K. (2009) PUMA- and Bax-induced autophagy contributes to apoptosis. Cell Death and Differentiation, 16(8), pp. 1135-1145. (doi: 10.1038/cdd.2009.28)

Bell, H. and Ryan, K. (2008) iASPP inhibition: Increased options in targeting the p53 family for cancer therapy. Cancer Research, 68(13), pp. 4959-4962. (doi: 10.1158/0008-5472.CAN-08-0182)

O'Prey, J., Wilkinson, S. and Ryan, K.M. (2008) Tumor Antigen LRRC15 Impedes Adenoviral Infection: Implications for Virus-Based Cancer Therapy. Journal of Virology, 82(12), pp. 5933-5939. (doi: 10.1128/JVI.02273-07)

Park, M. et al. (2008) Vorinostat and sorafenib increase ER stress, autophagy and apoptosis via ceramide-dependent CD95 and PERK activation. Cancer Biology and Therapy, 7(10), pp. 1648-1662.

Bell, H., Dufes, C., O'Prey, J., Crighton, D., Bergamaschi, D., Lu, X., Schatzlein, A., Vousden, K. and Ryan, K. (2007) A p53-derived apoptotic peptide derepresses p73 to cause tumor regression in vivo. Journal of Clinical Investigation, 117, pp. 1008-1018. (doi: 10.1172/JCI28920)

Bell, H. and Ryan, K. (2007) Targeting the p53 family for cancer therapy - 'Big brother' joins the fight. Cell Cycle, 6(16), pp. 1995-2000. (doi: 10.4161/cc.6.16.4614)

Crighton, D., Wilkinson, S. and Ryan, K. (2007) DRAM links autophagy to p53 and programmed cell death. Autophagy, 3(1), pp. 72-74.

Crighton, D., O'Prey, J., Bell, H.S. and Ryan, K.M. (2007) p73 regulates DRAM-independent autophagy that does not contribute to programmed cell death. Cell Death and Differentiation, 14(6), pp. 1071-1079. (doi: 10.1038/sj.cdd.4402108)

Ewings, K.E. and Ryan, K.M. (2007) Hzf and hCAS/CSE1L: making the right choice in p53-mediated tumour suppression. Cell Research, 17(10), pp. 829-831. (doi: 10.1038/cr.2007.85)

Bell, L.A., O'Prey, J. and Ryan, K.M. (2006) DNA-binding independent cell death from a minimal proapoptotic region of E2F-1. Oncogene, 25(41), pp. 5656-5663. (doi: 10.1038/sj.onc.1209580)

Crighton, D., Wilkinson, S., O'Prey, J., Syed, N., Smith, P., Harrison, P.R., Gasco, M., Garrone, O., Crook, T. and Ryan, K. (2006) DRAM, a p53-induced modulator of autophagy, is critical for apoptosis. Cell, 126(1), pp. 121-134. (doi: 10.1016/j.cell.2006.05.034)

Bell, H. and Ryan, K. (2005) Intracellular signalling and cancer: complex pathways lead to multiple targets. European Journal of Cancer, 41(2), pp. 206-215. (doi: 10.1016/j.ejca.2004.10.022)

Bell, L. and Ryan, K. (2004) Life and death decisions by E2F-1. Cell Death and Differentiation, 11(2), pp. 137-142. (doi: 10.1038/sj.cdd.4401324)

Crighton, D. and Ryan, K.M. (2004) Splicing DNA-damage responses to turnour cell death. Biochimica et Biophysica Acta: Reviews on Cancer, 1705(1), pp. 3-15. (doi: 10.1016/j.bbcan.2004.09.001)

Ryan, K. , O'Prey, J. and Vousden, K. (2004) Loss of nuclear factor-KB is tumor promoting but does not substitute for loss of p53. Cancer Research, 64(13), pp. 4415-4418. (doi: 10.1158/0008-5472.CAN-04-1474)

Wang, W., Cassidy, J., O'Brien, V., Ryan, K. and Collie-Duguid, E. (2004) Mechanistic and Predictive Profiling of 5-Fluorouracil Resistance in Human Cancer Cells. Cancer Research, 64(22), pp. 8167-8176. (doi: 10.1158/0008-5472.CAN-04-0970)

Gorgoulis, V.G., Zacharatos, P., Kotsinas, A., Kletsas, D., Mariatos, G., Zoumpourlis, V., Ryan, K.M. , Kittas, C. and Papavassiliou, A.G. (2003) p53 activates ICAM-1 (CD54) expression in an NF-kappaB-independent manner. EMBO Journal, 22(7), pp. 1567-1578. (doi: 10.1093/emboj/cdg157)

Ryan, K. and Vousden, K. (2002) Cancer: Pinning a change on p53. Nature, 419(6909), pp. 795-797. (doi: 10.1038/419795a)

Baird, J. et al. (2001) Differentiating embryonal stem cells are a rich source of haemopoietic gene products and suggest erythroid preconditioning of primitive haemopoietic stem cells. Journal of Biological Chemistry, 276(12), pp. 9189-9198. (doi: 10.1074/jbc.M008354200)

Blagosklonny, M., Giannakakou, P., Romanova, L., Ryan, K. , Vousden, K. and Fojo, T. (2001) Inhibition of HIF-1-and wild-type p53-stimulated transcription by codon Arg175 p53 mutants with selective loss of functions. Carcinogenesis, 22(6), pp. 861-867. (doi: 10.1093/carcin/22.6.861)

Ryan, K. , Phillips, A. and Vousden, K. (2001) Regulation and function of the p53 tumor suppressor protein. Current Opinion in Cell Biology, 13(3), pp. 332-337. (doi: 10.1016/S0955-0674(00)00216-7)

Conference or Workshop Item

Huser, C. , Heath, V., Pringle, M.-A. , Bell, A.K., Crighton, D., Ryan, K. , Inman, G. , Stein, T. and Gusterson, B. (2008) TSC22 in Mammary Gland Development and Breast Cancer. Breast Cancer Research 2008, London, UK, 13 May 2008. (doi: 10.1186/bcr1901)

This list was generated on Tue Nov 30 14:23:51 2021 GMT.