Professor Imran Ahmad

Professor of Urological Oncology (Clinical Research Garscube)

CRUK Beatson Institute, Garscube Estate, Switchback Road, Bearsden, Glasgow, G61 1BD

https://orcid.org/0000-0002-4404-1926

Research interests

Research Interests

I am currently Professor of Urologcial Oncology at the CRUK Beatson Institute and the School of Cancer Sciences (SCS) at the University of Glasgow. My current research interest is in understanding the mechanisms of treatment-resistance in advanced prostate cancer. Work in my laboratory uses state-of-the-art in vivo models in conjunction with patient samples to interrogate the disease processes in advanced and treatment-resistant prostate cancer. This work will help to provide information on drivers of prostate cancer progression and to identify novel biomarkers of disease and/or drug targets to treat the disease.

As an Honorary Consultant Urological Surgeon based at the Queen Elizabeth University Hospital in Glasgow, I have a special interest in robotic surgery for advanced prostate and bladder cancer. I have successfully set up and trained members of the Robotic Pelvic Cancer Service in the West of Scotland. As a partnership between NHS Greater Glasgow & Clyde and the University of Glasgow, the service has delivered several practice-changing clinical surgical trials over the last 5-years.

Awards & Prizes

2022 EAU Best Paper on Fundamental Research

2018 American Urological Association and BAUS Visiting Scholar Programme Winner
2017 Chairman’s Award at NHS GG&C (Introduction of Robotic Prostatectomy Service)
2017 EAU Best Paper on Fundamental Research
2014 ARTP Award 2014 (L'Association pour la Recherche sur les Tumeurs de la Prostate)
2013 Thomas and Margaret Smellie Prize (Best PhD thesis by a medical graduate) – University of Glasgow
2013 Hunterian Professorship – Royal College of Surgeons of England
2013 EAU Prostate Cancer Research Award 2013

Research groups

Comprehensive Cancer Models

Publications

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Number of items: 72.

2024

Mariappan, P. et al. (2024) Achieving benchmarks for national quality indicators reduces recurrence and progression in non-muscle-invasive bladder cancer. European Urology Oncology, (doi: 10.1016/j.euo.2024.01.012) (PMID:38296735) (In Press)

2023

Tibbo, A. J., Hartley, A., Vasan, R. , Shaw, R., Galbraith, L., Mui, E., Leung, H. Y. and Ahmad, I. (2023) MBTPS2 acts as a regulator of lipogenesis and cholesterol synthesis through SREBP signalling in prostate cancer. British Journal of Cancer, 128(11), pp. 1991-1999. (doi: 10.1038/s41416-023-02237-7) (PMID:36991255) (PMCID:PMC10205813)

Hartley, A. and Ahmad, I. (2023) The role of PPARγ in prostate cancer development and progression. British Journal of Cancer, 128(6), pp. 940-945. (doi: 10.1038/s41416-022-02096-8) (PMID:36510001) (PMCID:PMC10006070)

Bennett, S. S., Leung, H. Y. and Ahmad, I. (2023) A cohort analysis of patients receiving neoadjuvant androgen deprivation therapy prior to robot-assisted laparoscopic prostatectomy during the Covid-19 pandemic. Journal of Clinical Urology, 16(2), pp. 13-139. (doi: 10.1177/20514158211022216)

2022

Sooriakumaran, P. et al. (2022) Feasibility and safety of radical prostatectomy for oligo‐metastatic prostate cancer: the Testing Radical prostatectomy in men with prostate cancer and oligo‐Metastases to the bone (TRoMbone) trial. BJU International, 130(1), pp. 43-53. (doi: 10.1111/bju.15669) (PMID:34878715)

Catto, J. W. F. et al. (2022) Effect of robot-assisted radical cystectomy with intracorporeal urinary diversion vs open radical cystectomy on 90-day morbidity and mortality among patients with bladder cancer. JAMA: Journal of the American Medical Association, 327(21), pp. 2092-2103. (doi: 10.1001/jama.2022.7393) (PMID:35569079) (PMCID:PMC9109000)

Dinneen, E. et al. (2022) Negative mpMRI rules out extra-prostatic extension in prostate cancer before robot-assisted radical prostatectomy. Diagnostics, 12(5), e1057. (doi: 10.3390/diagnostics12051057) (PMID:35626214) (PMCID:PMC9139507)

2021

Massanova, M., Robertson, S., Barone, B., Butto, L., Caputo, V. F., Bhatt, J. R., Ahmad, I. , Bada, M., Obeidallah, A. and Crocetto, F. (2021) The comparison of imaging and clinical methods to estimate prostate volume: a single-centre retrospective study. Urologia Internationalis, 105(9-10), pp. 804-810. (doi: 10.1159/000516681) (PMID:34247169)

Stonier, T. et al. (2021) The "Is mpMRI Enough" or IMRIE Study: a multicentre evaluation of prebiopsy multiparametric magnetic resonance imaging compared with biopsy. European Urology Focus, 7(5), pp. 1027-1034. (doi: 10.1016/j.euf.2020.09.012) (PMID:33046412)

Ntala, C. et al. (2021) Analysis of prostate cancer tumor microenvironment identifies reduced stromal CD4 effector T-cell infiltration in tumors with pelvic nodal metastasis. European Urology Open Science, 29, pp. 19-29. (doi: 10.1016/j.euros.2021.05.001) (PMID:34337530) (PMCID:PMC8317840)

Galbraith, L. C.A., Mui, E., Nixon, C., Hedley, A., Strachan, D., MacKay, G., Sumpton, D., Sansom, O. J. , Leung, H. Y. and Ahmad, I. (2021) PPAR-gamma induced AKT3 expression increases levels of mitochondrial biogenesis driving prostate cancer. Oncogene, 40(13), pp. 2355-2366. (doi: 10.1038/s41388-021-01707-7) (PMID:33654198) (PMCID:PMC8016665)

Hartley, A., Leung, H. Y. and Ahmad, I. (2021) Targeting the BAF complex in advanced prostate cancer. Expert Opinion on Drug Discovery, 16(2), pp. 173-181. (doi: 10.1080/17460441.2020.1821644) (PMID:32936685)

2020

Mevel, R. et al. (2020) RUNX1 marks a luminal castration-resistant lineage established at the onset of prostate development. eLife, 9, e60225. (doi: 10.7554/elife.60225) (PMID:33025905) (PMCID:PMC7644213)

Mariappan, P. et al. (2020) Enhanced quality and effectiveness of transurethral resection of bladder tumour in non–muscle-invasive bladder cancer: a multicentre real-world experience from Scotland’s Quality Performance Indicators programme. European Urology, 78(4), pp. 520-530. (doi: 10.1016/j.eururo.2020.06.051) (PMID:32690321)

Dinneen, E. et al. (2020) NeuroSAFE PROOF randomised controlled feasibility study: brief report of perioperative outcomes, histological concordance, and feasibility. European Urology, 78(3), pp. 476-478. (doi: 10.1016/j.eururo.2020.03.052) (PMID:32340693)

Patel, R. et al. (2020) Activation of β-catenin cooperates with loss of Pten to drive AR-independent castration-resistant prostate cancer. Cancer Research, 80(3), pp. 576-590. (doi: 10.1158/0008-5472.CAN-19-1684) (PMID:31719098)

Loveridge, C. J. et al. (2020) BRF1 accelerates prostate tumourigenesis and perturbs immune infiltration. Oncogene, 39, pp. 1797-1806. (doi: 10.1038/s41388-019-1106-x) (PMID:31740786) (PMCID:PMC7033044)

2019

Clyde, M., McAllister, J., Obeidallah, A. and Ahmad, I. (2019) Actinomyces odontolyticus infection 3 months post-robotic-assisted laparoscopic prostatectomy. BMJ Case Reports, 12(4), e228184. (doi: 10.1136/bcr-2018-228184) (PMID:30981988)

2018

Salji, M. , Hendry, J., Patel, A., Ahmad, I. , Nixon, C. and Leung, H. Y. (2018) Peri-prostatic fat volume measurement as a predictive tool for castration resistance in advanced prostate cancer. European Urology Focus, 4(6), pp. 858-866. (doi: 10.1016/j.euf.2017.01.019) (PMID:28753854) (PMCID:PMC6314965)

Ahmad, I. and Sansom, O. J. (2018) Role of Wnt signalling in advanced prostate cancer. Journal of Pathology, 245, pp. 3-5. (doi: 10.1002/path.5029) (PMID:29314004)

Galbraith, L., Leung, H. Y. and Ahmad, I. (2018) Lipid pathway deregulation in advanced prostate cancer. Pharmacological Research, 131, pp. 177-184. (doi: 10.1016/j.phrs.2018.02.022) (PMID:29466694)

Patel, R. et al. (2018) Sprouty2 loss‐induced IL6 drives castration‐resistant prostate cancer through scavenger receptor B1. EMBO Molecular Medicine, 10(4), e8347. (doi: 10.15252/emmm.201708347) (PMID:29540470) (PMCID:PMC5887544)

2017

Loveridge, C. J. et al. (2017) Analysis of Nkx3.1:Cre-driven Erk5 deletion reveals a profound spinal deformity which is linked to increased osteoclast activity. Scientific Reports, 7, 13241. (doi: 10.1038/s41598-017-13346-8) (PMID:29038439) (PMCID:PMC5643304)

Loveridge, C. J. et al. (2017) Increased T cell infiltration elicited by Erk5 deletion in a Pten-deficient mouse model of prostate carcinogenesis. Cancer Research, 77(12), pp. 3158-3168. (doi: 10.1158/0008-5472.CAN-16-2565) (PMID:28515147)

Tan, W. S., Lamb, B. W., Tan, M.-Y., Ahmad, I. , Sridhar, A., Nathan, S., Hines, J., Shaw, G., Briggs, T. P. and Kelly, J. D. (2017) In-depth critical analysis of complications following robot-assisted radical cystectomy with intracorporeal urinary diversion. European Urology Focus, 3(2-3), pp. 273-279. (doi: 10.1016/j.euf.2016.06.002) (PMID:28753745)

2016

Salji, M. , Ahmad, I. and Winchester, C. (2016) Non-clinical research – laboratory based. Journal of Clinical Urology, 9(6), pp. 362-364. (doi: 10.1177/2051415816650134)

Lamb, B. W. et al. (2016) Benefits of robotic cystectomy with intracorporeal diversion for patients with low cardiorespiratory fitness: a prospective cohort study. Urologic Oncology: Seminars and Original Investigations, 34(9), 417.e17-417.e23. (doi: 10.1016/j.urolonc.2016.04.006) (PMID:27197920)

Ahmad, I. et al. (2016) Sleeping Beauty screen reveals Pparg activation in metastatic prostate cancer. Proceedings of the National Academy of Sciences of the United States of America, 113(29), pp. 8290-8295. (doi: 10.1073/pnas.1601571113) (PMID:27357679) (PMCID:PMC4961202)

2015

Loveridge, C., Mui, E., Ahmad, I. , Welsh, M., Tan, E., Fleming, J., Sansom, O. and Leung, H. (2015) The Role of Erk5 in Prostate Carcinogenesis. In: 11th World Congress on Urological Research, Nijmegen, The Nertherlands, September 2015, (Unpublished)

Zekri, J., Ahmad, I. , Elkhodary, T.R., Al-Gahmi, A., Hassouna, A., El Sayed, M.E., Ur Rehman, J., Karim, S.M. and Bin Sadiq, B. (2015) Lymph node ratio may predict relapse free survival and overall survival in patients with stage II & III colorectal carcinoma. Hepato-Gastroenterology, 62(138), pp. 291-294. (PMID:25916051)

Ahmad, I. (2015) The role of WNT signalling in urothelial cell carcinoma. Annals of the Royal College of Surgeons of England, 97(7), pp. 481-486. (doi: 10.1308/rcsann.2015.0008) (PMID:26274747) (PMCID:PMC5210134)

2014

Rajan, P. et al. (2014) Next-generation sequencing of advanced prostate cancer treated with androgen-deprivation therapy. European Urology, 66(1), pp. 32-39. (doi: 10.1016/j.eururo.2013.08.011) (PMID:24054872) (PMCID:PMC4062940)

Choudhury, Y., Yang, Z., Ahmad, I. , Nixon, C., Salt, I. P. and Leung, H. Y. (2014) AMP-activated protein kinase (AMPK) as a potential therapeutic target independent of PI3K/Akt signaling in prostate cancer. Oncoscience, 1(6), pp. 446-456. (doi: 10.18632/oncoscience.49) (PMID:25594043) (PMCID:PMC4284621)

Stockley, J., Villasevil, M. E. M., Nixon, C., Ahmad, I. , Leung, H. and Rajan, P. (2014) The RNA-binding protein hnRNPA2 regulates β-catenin protein expression and is overexpressed in prostate cancer. RNA Biology, 11(6), pp. 755-765. (doi: 10.4161/rna.28800) (PMID:24823909) (PMCID:PMC4156506)

2013

Patel, R. et al. (2013) Sprouty2, PTEN, and PP2A interact to regulate prostate cancer progression. Journal of Clinical Investigation, 123(3), pp. 1157-1175. (doi: 10.1172/JCI63672)

Ahmad, I. , Gao, M., Patel, R. and Leung, H.Y. (2013) Modelling synergistic interactions between HER2, Sprouty2 and PTEN in driving prostate carcinogenesis. Asian Journal of Andrology, 15(3), pp. 323-327. (doi: 10.1038/aja.2013.40)

Ahmad, I. et al. (2013) Mir143 expression inversely correlates with nuclear ERK5 immunoreactivity in clinical prostate cancer. British Journal of Cancer, 108(1), pp. 149-154. (doi: 10.1038/bjc.2012.510)

Yang, Z., Laird, A., Monaghan, A., Seywright, M., Ahmad, I. and Leung, H.Y. (2013) Incidental seminal vesicle amyloidosis observed in diagnostic prostate biopsies—are routine investigations for systemic amyloidosis warranted? Asian Journal of Andrology, 15(1), pp. 149-151. (doi: 10.1038/aja.2012.125)

2012

Ahmad, I. , Iwata, T. and Leung, H.Y. (2012) Mechanisms of FGFR-mediated carcinogenesis. Biochimica et Biophysica Acta: Molecular Cell Research, 1823(4), pp. 850-860. (doi: 10.1016/j.bbamcr.2012.01.004)

McCall, P. et al. (2012) NFκB signalling is upregulated in a subset of castrate-resistant prostate cancer patients and correlates with disease progression. British Journal of Cancer, 107(9), pp. 1554-1563. (doi: 10.1038/bjc.2012.372)

2011

Armstrong, K., Ahmad, I. , Kalna, G., Tan, S.S., Edwards, J. , Robson, C.N. and Leung, H.Y. (2011) Upregulated FGFR1 expression is associated with the transition of hormone-naive to castrate-resistant prostate cancer. British Journal of Cancer, 105(9), pp. 1362-1369. (doi: 10.1038/bjc.2011.367)

Ahmad, I. , Singh, L.B., Foth, M., Morris, C.-A., Taketo, M.M., Wu, X.-R., Leung, H.Y. , Sansom, O.J. and Iwata, T. (2011) K-Ras and β-catenin mutations cooperate with Fgfr3 mutations in mice to promote tumorigenesis in the skin and lung, but not in the bladder. Disease Models and Mechanisms, 4(4), pp. 548-555. (doi: 10.1242/dmm.006874)

Ahmad, I. , Patel, R., Liu, Y., Singh, L.B., Taketo, M.M., Wu, X.-R., Leung, H.Y. and Sansom, O.J. (2011) Ras mutation cooperates with β-catenin activation to drive bladder tumourigenesis. Cell Death and Disease, 2, e124. (doi: 10.1038/cddis.2011.7)

Tan, S.S., Ahmad, I. , Bennett, H.L., Singh, L., Nixon, C., Seywright, M., Barnetson, R.J., Edwards, J. and Leung, H. (2011) GRP78 up-regulation is associated with androgen receptor status, Hsp70-Hsp90 client proteins and castrate-resistant prostate cance. Journal of Pathology, 223(1), pp. 81-87. (doi: 10.1002/path.2795) (PMID:21125667)

Ahmad, I. et al. (2011) β-Catenin activation synergizes with PTEN loss to cause bladder cancer formation. Oncogene, 30(2), pp. 178-189. (doi: 10.1038/onc.2010.399)

Ahmad, I. et al. (2011) HER2 overcomes PTEN (loss)-induced senescence to cause aggressive prostate cancer. Proceedings of the National Academy of Sciences of the United States of America, 108(39), pp. 16392-16397. (doi: 10.1073/pnas.1101263108)

Ramsay, A.K. et al. (2011) ERK5 signalling in prostate cancer promotes an invasive phenotype. British Journal of Cancer, 104(4), pp. 664-672. (doi: 10.1038/sj.bjc.6606062)

2010

Ahmad, I. and Sansom, O.J. (2010) Today’s research: tomorrow’s therapies. Future Oncology, 6(7), pp. 1095-1097. (doi: 10.2217/fon.10.77)

2009

Ahmad, I. , Krishna, N.S., Small, D.R. and Conn, I.G. (2009) Aetiology and management of acute female urinary retention. British Journal of Medical and Surgical Urology, 2(1), pp. 27-33. (doi: 10.1016/j.bjmsu.2008.10.004)

Ahmad, I. , Sansom, O.J. and Leung, H.Y. (2009) The role of murine models of prostate cancer in drug target discovery and validation. Expert Opinion on Drug Discovery, 4(8), pp. 879-888. (doi: 10.1517/17460440903049308)

Nelson, A.W., Ahmad, I. , Pickard, R.S. and Leung, H.Y. (2009) The new BAUS section of academic urology: a survey of the urological community. British Journal of Medical and Surgical Urology, 2(4), pp. 147-153. (doi: 10.1016/j.bjmsu.2009.04.003)

2008

Ahmad, I. , Barnetson, R.J. and Krishna, N.S. (2008) Keratinizing squamous metaplasia of the bladder: a review. Urologia Internationalis, 81(3), pp. 247-251. (doi: 10.1159/000151398) (PMID:18931537)

Ahmad, I. , Sarath Krishna, N., Small, D.R. and Conn, I.G. (2008) Management of female urinary retention: an 11 year experience. BJU International, 101(S5), p. 29.

Ahmad, I. , Sarath Krishna, N. and Meddings, R.N. (2008) Sequential hydrodistension and intravesical instillation of hyaluronic acid under general anaesthesia for treatment of refractory interstitial cystitis: a pilot study. International Urogynecology Journal, 19(4), pp. 543-546. (doi: 10.1007/s00192-007-0443-4)

Ahmad, I. , Sansom, O.J. and Leung, H.Y. (2008) Advances in mouse models of prostate cancer. Expert Reviews in Molecular Medicine, 10, e16. (doi: 10.1017/S1462399408000689)

Ahmad, I. , Small, D.R. and Granitsiotis, P. (2008) The role of ultrasound for the measurement of bladder volume. Urology News, 12(2), pp. 10-13.

2007

Ahmad, I. and Granitsiotis, P. (2007) Urological follow-up of adult spina bifida patients. Neurourology and Urodynamics, 26(7), pp. 978-980. (doi: 10.1002/nau.20447) (PMID:17626275)

Ahmad, I. and Konduru, S. (2007) Change in functional status of patients whilst awaiting primary total knee arthroplasty. Surgeon, 5(5), pp. 266-267. (doi: 10.1016/S1479-666X(07)80022-9) (PMID:17958223)

Ahmad, I. and Patil, S. (2007) Isolated deep peroneal (fibular) nerve palsy in association with primary total hip arthroplasty. Clinical Anatomy, 20(6), pp. 703-704. (doi: 10.1002/ca.20468)

Ahmad, I. , Sarath Krishna, N., Clark, R., Al-Saffar, N. and Nairn, R. (2007) Interval development of testicular carcinoma in patients with previously demonstrated testicular microlithiasis. BJU International, 99(S4), p. 51.

Ahmad, I. , Sarath Krishna, N., Small, D.R., Morrison, L. and Akhtar, M.N. (2007) CT urogram as an initial investigation in Frank haematuria. BJU International, 99(S4), p. 22.

Ahmad, I. and Krishna, N. S. (2007) Hemospermia. Journal of Urology, 177(5), pp. 1613-1618. (doi: 10.1016/j.juro.2007.01.004) (PMID:17437771)

Ahmad, I. , Sarath Krishna, N., Small, D.R., Morrison, L. and Akhtar, M.N. (2007) Prostate cancer incidence in patients on finasteride for lower urinary tract symptoms. European Urology Supplements, 6(2), p. 177. (doi: 10.1016/S1569-9056(07)60615-0)

Ahmad, I. , Sarath Krishna, N. and Meddings, R.N. (2007) Role of EMLA cream in biopsy and excision of penile lesions. Annals of the Royal College of Surgeons of England, 89(1), p. 73. (doi: 10.1308/rcsann.2007.89.1.73a) (PMCID:PMC1963559)

Ahmad, I. , Adlard, P., Duncan, P., Bunyan, D.J., Harvey, J., Tolmie, J. and Donaldson, M.D.C. (2007) A novel mutation of DAX-1 with an atypical presentation of X-linked adrenal hypoplasia congenita. Hormone Research, 68, pp. 32-37.

Ahmad, I. , Hilmy, M., Small, D.R. and Conn, I.G. (2007) Is urethroplasty a feasible long-term solution for urethral stricture? Journal of Urology, 177(S4), pp. 13-14.

Ahmad, I. , Krishna, N.S., Clark, R., Nairn, R. and Al-Saffar, N. (2007) Testicular microlithiasis: prevalence and risk of concurrent and interval development of testicular tumor in a referred population. International Urology and Nephrology, 39(4), pp. 1177-1181. (doi: 10.1007/s11255-007-9203-0)

Ahmad, I. , Paterson, W.F., Lin, L., Adlard, P., Duncan, P. and Donaldson, M.D.C. (2007) A novel missense mutation in Dax-1 with an unusual presentation of X-linked adrenal hypoplasia congenita. Hormone Research, 68(1), pp. 32-37. (doi: 10.1159/000099835)

Ahmad, I. , Sarath Krishna, N. and Meddings, R.N. (2007) Role of hydrodistension and intravesical instillation of cystistat for resistant interstitial cystitis. Journal of Urology, 177(S4), p. 47.

Ahmad, I. , Sarath Krishna, N., Small, D.R., Morrison, L. and Akhtar, M.N. (2007) Prostate cancer incidence in patients on finasteride for lower urinary tract symptoms. Journal of Urology, 177(S4), p. 75.

2006

Ahmad, I. , Sarath Krishna, N. and Meddings, R.N. (2006) Role of hydrodistension and intravesical instillation of cystistat for resistant interstitial cystitis. BJU International, 97(S3), p. 34.

This list was generated on Wed Apr 17 16:01:30 2024 BST.

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