Professor Helen Wheadon

  • Professor of Stem Cell Regulation (Paul O'Gorman Leukaemia Research Centre)

telephone: 01413017884
email: Helen.Wheadon@glasgow.ac.uk

R323 Level 3, Leukaemia Research Centre, Gartnavel General Hospital, Glasgow G11 0YN

Import to contacts

ORCID iDhttps://orcid.org/0000-0001-9902-3170

Research interests

Research groups

Publications

List by: Type | Date

Jump to: 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2011 | 2010 | 2009 | 2008 | 2004 | 2003 | 2002
Number of items: 42.

2025

Bubnova, Xenia, Wheadon, Helen ORCID logoORCID: https://orcid.org/0000-0001-9902-3170 and Hope, Lauren (2025) Evaluation of current mouse in vivo models and advanced in vitro models for leukaemia research. Blood Reviews, (doi: 10.1016/j.blre.2025.101318) (In Press)

2024

Donnelly, H. et al. (2024) Bioengineered niches that recreate physiological extracellular matrix organisation to support long-term haematopoietic stem cells. Nature Communications, 15, 5791. (doi: 10.1038/s41467-024-50054-0)

Busch, Caroline, Nyamondo, Kudzai and Wheadon, Helen ORCID logoORCID: https://orcid.org/0000-0001-9902-3170 (2024) Complexities of modelling the bone marrow microenvironment to facilitate haematopoietic research. Experimental Hematology, 135, 104233. (doi: 10.1016/j.exphem.2024.104233) (PMID:38740324)

Dawson, A. et al. (2024) Leukaemia exposure alters the transcriptional profile and function of BCR::ABL1 negative macrophages in the bone marrow niche. Nature Communications, 15, 1090. (doi: 10.1038/s41467-024-45471-0) (PMID:38316788) (PMCID:PMC10844594)

Nyamondo, Kudzai and Wheadon, Helen ORCID logoORCID: https://orcid.org/0000-0001-9902-3170 (2024) Microenvironment alterations through time leading to myeloid malignancies. British Journal of Pharmacology, 181(2), pp. 283-294. (doi: 10.1111/bph.15924) (PMID:35844165)

2023

Busch, Caroline, Mulholland, Theresa, Zagnoni, Michele, Dalby, Matthew ORCID logoORCID: https://orcid.org/0000-0002-0528-3359, Berry, Catherine ORCID logoORCID: https://orcid.org/0000-0002-6485-2187 and Wheadon, Helen ORCID logoORCID: https://orcid.org/0000-0001-9902-3170 (2023) Overcoming BCR::ABL1 dependent and independent survival mechanisms in chronic myeloid leukaemia using a multi-kinase targeting approach. Cell Communication and Signaling, 21, 342. (doi: 10.1186/s12964-023-01363-2) (PMID:38031192) (PMCID:PMC10685629)

Zarou, M. M. et al. (2023) Leukaemia Exposure Alters the Transcriptional Profile and Function of Macrophages in the Bone Marrow Niche. 65th ASH Annual Meeting and Exposition, San Diego, California, USA, 09-12 Dec 2023. (doi: 10.1182/blood-2023-181630)

2022

Parry, Narissa, Busch, Caroline, Aßmann, Victoria, Cassels, Jennifer, Hair, Alan, Helgason, G. Vignir ORCID logoORCID: https://orcid.org/0000-0003-1616-132X, Wheadon, Helen ORCID logoORCID: https://orcid.org/0000-0001-9902-3170 and Copland, Mhairi ORCID logoORCID: https://orcid.org/0000-0002-7655-016X (2022) BH3 mimetics in combination with nilotinib or ponatinib represent a promising therapeutic strategy in blast phase chronic myeloid leukemia. Cell Death Discovery, 8, 457. (doi: 10.1038/s41420-022-01211-1) (PMID:36379918) (PMCID:PMC9666353)

Pancheva, Alexandrina, Wheadon, Helen ORCID logoORCID: https://orcid.org/0000-0001-9902-3170, Rogers, Simon ORCID logoORCID: https://orcid.org/0000-0003-3578-4477 and Otto, Thomas D. ORCID logoORCID: https://orcid.org/0000-0002-1246-7404 (2022) Using topic modeling to detect cellular crosstalk in scRNA-seq. PLoS Computational Biology, 18(4), e1009975. (doi: 10.1371/journal.pcbi.1009975) (PMID:35395014) (PMCID:PMC9064087)

2021

Miari, Katerina E. ORCID logoORCID: https://orcid.org/0000-0003-3008-966X, Guzman, Monica L., Wheadon, Helen ORCID logoORCID: https://orcid.org/0000-0001-9902-3170 and Williams, Mark T. S. (2021) Macrophages in Acute Myeloid Leukaemia: significant players in therapy resistance and patient outcomes. Frontiers in Cell and Developmental Biology, 9, 692800. (doi: 10.3389/fcell.2021.692800) (PMID:34249942) (PMCID:PMC8264427)

Chantkran, Wittawat, Hsieh, Ya-Ching, Zheleva, Daniella, Frame, Sheelagh, Wheadon, Helen ORCID logoORCID: https://orcid.org/0000-0001-9902-3170 and Copland, Mhairi ORCID logoORCID: https://orcid.org/0000-0002-7655-016X (2021) Interrogation of novel CDK2/9 inhibitor fadraciclib (CYC065) as a potential therapeutic approach for AML. Cell Death Discovery, 7, 137. (doi: 10.1038/s41420-021-00496-y) (PMID:34112754) (PMCID:PMC8192769)

Parry, Narissa, Wheadon, Helen ORCID logoORCID: https://orcid.org/0000-0001-9902-3170 and Copland, Mhairi ORCID logoORCID: https://orcid.org/0000-0002-7655-016X (2021) The application of BH3 mimetics in myeloid leukemias. Cell Death and Disease, 12, 222. (doi: 10.1038/s41419-021-03500-6) (PMID:33637708) (PMCID:PMC7908010)

2020

McAllister, Milly, Constancio, Vera, Patek, Samantha, Gan, Hao, Bailey, Peter ORCID logoORCID: https://orcid.org/0000-0002-0857-2041, Wheadon, Helen ORCID logoORCID: https://orcid.org/0000-0001-9902-3170, Underwood, Mark, Leung, Hing ORCID logoORCID: https://orcid.org/0000-0002-3933-3975 and Edwards, Joanne ORCID logoORCID: https://orcid.org/0000-0002-7192-6906 (2020) Inflammatory infiltration is associated with AR expression and poor prognosis in hormone naïve prostate cancer. Prostate, 80(15), pp. 1353-1364. (doi: 10.1002/pros.24064) (PMID:32846021)

Kinstrie, R. et al. (2020) CD93 is expressed on chronic myeloid leukemia stem cells and identifies a quiescent population which persists after tyrosine kinase inhibitor therapy. Leukemia, 34(6), pp. 1613-1625. (doi: 10.1038/s41375-019-0684-5) (PMID:31896780) (PMCID:PMC7272220)

2019

Wheadon, Helen ORCID logoORCID: https://orcid.org/0000-0001-9902-3170 and Busch, Caroline (2019) Bone marrow niche crosses paths with BMPs: a road to protection and persistence in CML. Biochemical Society Transactions, 47(5), pp. 1307-1325. (doi: 10.1042/BST20190221) (PMID:31551354)

2018

Toofan, Parto, Busch, Caroline, Morrison, Heather, O'Brien, Stephen, Jørgensen, Heather ORCID logoORCID: https://orcid.org/0000-0003-4663-4191, Copland, Mhairi ORCID logoORCID: https://orcid.org/0000-0002-7655-016X and Wheadon, Helen ORCID logoORCID: https://orcid.org/0000-0001-9902-3170 (2018) Chronic myeloid leukemia cells require the bone morphogenic protein pathway for cell cycle progression and self-renewal. Cell Death and Disease, 9, 927. (doi: 10.1038/s41419-018-0905-2) (PMID:30206237) (PMCID:PMC6134087)

2017

Biggs, M. J.P. et al. (2017) The functional response of mesenchymal stem cells to electron-beam patterned elastomeric surfaces presenting micrometer to nanoscale heterogeneous rigidity. Advanced Materials, 29(39), 1702119. (doi: 10.1002/adma.201702119) (PMID:28861921)

Lewis, Natasha S., Lewis, Emily E.L., Mullin, Margaret, Wheadon, Helen ORCID logoORCID: https://orcid.org/0000-0001-9902-3170, Dalby, Matthew J. ORCID logoORCID: https://orcid.org/0000-0002-0528-3359 and Berry, Catherine C. ORCID logoORCID: https://orcid.org/0000-0002-6485-2187 (2017) Magnetically levitated mesenchymal stem cell spheroids cultured with a collagen gel maintain phenotype and quiescence. Journal of Tissue Engineering, 8, pp. 1-11. (doi: 10.1177/2041731417704428) (PMID:28616152) (PMCID:PMC5460809)

2016

Horne, Gillian A. ORCID logoORCID: https://orcid.org/0000-0001-9741-7352, Morrison, Heather, Campbell, Victoria, Kinstrie, Ross, Cassels, Jennifer, Hair, Alan, Vetrie, David ORCID logoORCID: https://orcid.org/0000-0003-2075-4662, Wheadon, Helen ORCID logoORCID: https://orcid.org/0000-0001-9902-3170, Holyoake, Tessa L. and Copland, Mhairi ORCID logoORCID: https://orcid.org/0000-0002-7655-016X (2016) Notch Pathway Activation Targets Leukemic Stem Cells in Chronic-Phase Chronic Myeloid Leukemia (CP-CML). American Society of Hematology 58th Annual Meeting, San Diego, CA, USA, 3-6 Dec 2016.

Chaudhury, Shahzya S. ORCID logoORCID: https://orcid.org/0000-0002-6732-9949, Wheadon, Helen ORCID logoORCID: https://orcid.org/0000-0001-9902-3170, Gibson, Brenda and Keeshan, Karen ORCID logoORCID: https://orcid.org/0000-0001-7266-0890 (2016) The Bone Marrow Niche Distinguishes Young and Old Leukemia. 58th ASH Annual Meeting, San Diego, CA, USA, 3-6 Dec 2016.

Toofan, Parto and Wheadon, Helen ORCID logoORCID: https://orcid.org/0000-0001-9902-3170 (2016) Role of the bone morphogenic protein pathway in developmental haemopoiesis and leukaemogenesis. Biochemical Society Transactions, 44(5), pp. 1455-1463. (doi: 10.1042/BST20160104) (PMID:27911727)

Lewis, Emily Elizabeth Louise, Wheadon, Helen ORCID logoORCID: https://orcid.org/0000-0001-9902-3170, Lewis, Natasha, Yang, Jingli, Mullin, Margaret, Hursthouse, Andrew, Stirling, David, Dalby, Matthew John ORCID logoORCID: https://orcid.org/0000-0002-0528-3359 and Berry, Catherine Cecilia ORCID logoORCID: https://orcid.org/0000-0002-6485-2187 (2016) A quiescent, regeneration-responsive tissue engineered mesenchymal stem cell bone marrow niche model via magnetic levitation. ACS Nano, 10(9), pp. 8346-8354. (doi: 10.1021/acsnano.6b02841) (PMID:27602872)

Middleton, O., Wheadon, H. ORCID logoORCID: https://orcid.org/0000-0001-9902-3170 and Michie, A. ORCID logoORCID: https://orcid.org/0000-0002-5404-475X (2016) Classical complement pathway. In: Ratcliffe, M.J.H. (ed.) Encyclopedia of Immunobiology, 1st Edition. Elsevier: New York, NY. ISBN 9780123742797 (doi: 10.1016/B978-0-12-374279-7.02014-2)

Irvine, D. A. et al. (2016) Deregulated hedgehog pathway signaling is inhibited by the smoothened antagonist LDE225 (Sonidegib) in chronic phase chronic myeloid leukaemia. Scientific Reports, 6, 25476. (doi: 10.1038/srep25476) (PMID:27157927) (PMCID:PMC4860619)

2015

Ford, C. A. et al. (2015) Oncogenic properties of apoptotic tumor cells in aggressive B cell lymphoma. Current Biology, 25(5), pp. 577-588. (doi: 10.1016/j.cub.2014.12.059) (PMID:25702581) (PMCID:PMC4353688)

Kranc, K. R. et al. (2015) Acute loss of Cited2 impairs Nanog expression and decreases self-renewal of mouse embryonic stem cells. Stem Cells, 33(3), pp. 699-712. (doi: 10.1002/stem.1889) (PMID:25377420)

Middleton, O., Cosimo, E., Dobbin, E., McCaig, A.M., Clarke, C., Brant, A.M., Leach, M.T., Michie, A.M. ORCID logoORCID: https://orcid.org/0000-0002-5404-475X and Wheadon, H. ORCID logoORCID: https://orcid.org/0000-0001-9902-3170 (2015) Complement deficiencies limit CD20 monoclonal antibody treatment efficacy in CLL. Leukemia, 29(1), pp. 107-114. (doi: 10.1038/leu.2014.146) (PMID:24787488)

2014

Gallipoli, Paolo, Cook, Amy, Rhodes, Susan ORCID logoORCID: https://orcid.org/0000-0001-6676-890X, Hopcroft, Lisa ORCID logoORCID: https://orcid.org/0000-0002-7022-1322, Wheadon, Helen ORCID logoORCID: https://orcid.org/0000-0001-9902-3170, Whetton, Anthony D., Jorgensen, Heather G. ORCID logoORCID: https://orcid.org/0000-0003-4663-4191, Bhatia, Ravi and Holyoake, Tessa L. (2014) JAK2/STAT5 inhibition by nilotinib with ruxolitinib contributes to the elimination of chronic phase CML CD34+ cells in vitro and in vivo. Blood, 124(9), pp. 1492-1501. (doi: 10.1182/blood-2013-12-545640) (PMID:24957147) (PMCID:PMC4148771)

Toofan, Parto, Irvine, David, Hopcroft, Lisa ORCID logoORCID: https://orcid.org/0000-0002-7022-1322, Copland, Mhairi ORCID logoORCID: https://orcid.org/0000-0002-7655-016X and Wheadon, Helen ORCID logoORCID: https://orcid.org/0000-0001-9902-3170 (2014) The role of the bone morphogenetic proteins in leukaemic stem cell persistence. Biochemical Society Transactions, 42(4), pp. 809-815. (doi: 10.1042/BST20140037)

2013

Cosimo, E. et al. (2013) Inhibition of NF-κB-mediated signaling by the cyclin-dependent kinase inhibitor CR8 overcomes pro-survival stimuli to induce apoptosis in chronic lymphocytic leukemia cells. Clinical Cancer Research, 19(9), pp. 2393-2405. (doi: 10.1158/1078-0432.CCR-12-2170)

Rhodes, Susan ORCID logoORCID: https://orcid.org/0000-0001-6676-890X, Copland, Mhairi ORCID logoORCID: https://orcid.org/0000-0002-7655-016X, Hopcroft, Lisa ORCID logoORCID: https://orcid.org/0000-0002-7022-1322, Sayeski, Peter and Wheadon, Helen ORCID logoORCID: https://orcid.org/0000-0001-9902-3170 (2013) Identification of JAK2 dependent transcriptional regulators in CML. In: 42nd Annual Scientific Meeting of the ISEH – Society for Hematology and Stem Cells, Vienna, Austria, 22-25 Aug 2013, S47-S47.

Sands, W.A., Copland, M. ORCID logoORCID: https://orcid.org/0000-0002-7655-016X and Wheadon, H. ORCID logoORCID: https://orcid.org/0000-0001-9902-3170 (2013) Targeting self-renewal pathways in myeloid malignancies. Cell Communication and Signaling, 11(33), (doi: 10.1186/1478-811X-11-33)

Tarafdar, A., Dobbin, E., Corrigan, P., Freeburn, R. and Wheadon, H. ORCID logoORCID: https://orcid.org/0000-0001-9902-3170 (2013) Canonical Wnt signaling promotes early hematopoietic progenitor formation and erythroid specification during embryonic stem cell differentiation. PLoS ONE, 8(11), e81030. (doi: 10.1371/journal.pone.0081030) (PMID:24324557) (PMCID:PMC3850021)

2011

Wheadon, H. ORCID logoORCID: https://orcid.org/0000-0001-9902-3170, Ramsey, J.M., Dobbin, E., Dickson, G.J., Corrigan, P.M., Freeburn, R.W. and Thompson, A. (2011) Differential Hox expression in murine embryonic stem cell models of normal and malignant hematopoiesis. Stem Cells and Development, 20(8), pp. 1465-1476. (doi: 10.1089/scd.2010.0226)

2010

Dobbin, E., Graham, C., Freeburn, R.W., Unwin, R.D., Griffiths, J.R., Pierce, A., Whetton, A.D. and Wheadon, H. ORCID logoORCID: https://orcid.org/0000-0001-9902-3170 (2010) Proteomic analysis reveals a novel mechanism induced by the leukemic oncogene Tel/PDGFRβ in stem cells: activation of the interferon response pathways. Stem Cell Research, 5(3), pp. 226-243. (doi: 10.1016/j.scr.2010.08.001)

2009

Dobbin, E., Graham, C., Corrigan, P., Thomas, K., Freeburn, R. and Wheadon, H. ORCID logoORCID: https://orcid.org/0000-0001-9902-3170 (2009) Tel/PDGFRβ induces stem cell differentiation via the Ras/ERK and STAT5 signaling pathways. Experimental Hematology, 37(1), pp. 111-121. (doi: 10.1016/j.exphem.2008.09.012)

Corrigan, P.M., Dobbin, E., Freeburn, R.W. and Wheadon, H. ORCID logoORCID: https://orcid.org/0000-0001-9902-3170 (2009) Patterns of Wnt/Fzd/LRP gene expression during embryonic hematopoiesis. Stem Cells and Development, 18(5), pp. 759-771. (doi: 10.1089/scd.2008.0270)

2008

Dobbin, E., Corrigan, P.M., Walsh, C.P., Welham, M.J., Freeburn, R.W. and Wheadon, H. ORCID logoORCID: https://orcid.org/0000-0001-9902-3170 (2008) Tel/PDGFRβ inhibits self-renewal and directs myelomonocytic differentiation of ES cells. Leukemia Research, 32(10), pp. 1554-1564. (doi: 10.1016/j.leukres.2008.02.007)

2004

Paling, N.R.D., Wheadon, H. ORCID logoORCID: https://orcid.org/0000-0001-9902-3170, Bone, H.K. and Welham, M.J. (2004) Regulation of embryonic stem cell self-renewal by phosphoinositide 3-kinase-dependent signaling. Journal of Biological Chemistry, 279(46), pp. 48063-48070. (doi: 10.1074/jbc.M406467200)

2003

Wheadon, H. ORCID logoORCID: https://orcid.org/0000-0001-9902-3170, Edmead, C. and Welham, M.J. (2003) Regulation of interleukin-3-induced substrate phosphorylation and cell survival by SHP-2 (Src-homology protein tyrosine phosphatase 2). Biochemical Journal, 376(1), pp. 147-157. (doi: 10.1042/BJ20031160)

Wheadon, H. ORCID logoORCID: https://orcid.org/0000-0001-9902-3170 and Welham, M.J. (2003) The coupling of TEL/PDGF R to distinct functional responses is modulated by the presence of cytokine: involvement of mitogen-activated protein kinases. Blood, 102(4), pp. 1480-1489. (doi: 10.1182/blood-2002-09-2974)

2002

Wheadon, H. ORCID logoORCID: https://orcid.org/0000-0001-9902-3170, Paling, N.R.D. and Welham, M.J. (2002) Molecular interactions of SHP1 and SHP2 in IL-3-signalling. Cellular Signalling, 14(3), pp. 219-229. (doi: 10.1016/S0898-6568(01)00241-8)

This list was generated on Sat Jul 5 06:52:31 2025 BST.
Jump to: Articles | Book Sections | Conference or Workshop Item | Conference Proceedings
Number of items: 42.

Articles

Bubnova, Xenia, Wheadon, Helen ORCID logoORCID: https://orcid.org/0000-0001-9902-3170 and Hope, Lauren (2025) Evaluation of current mouse in vivo models and advanced in vitro models for leukaemia research. Blood Reviews, (doi: 10.1016/j.blre.2025.101318) (In Press)

Donnelly, H. et al. (2024) Bioengineered niches that recreate physiological extracellular matrix organisation to support long-term haematopoietic stem cells. Nature Communications, 15, 5791. (doi: 10.1038/s41467-024-50054-0)

Busch, Caroline, Nyamondo, Kudzai and Wheadon, Helen ORCID logoORCID: https://orcid.org/0000-0001-9902-3170 (2024) Complexities of modelling the bone marrow microenvironment to facilitate haematopoietic research. Experimental Hematology, 135, 104233. (doi: 10.1016/j.exphem.2024.104233) (PMID:38740324)

Dawson, A. et al. (2024) Leukaemia exposure alters the transcriptional profile and function of BCR::ABL1 negative macrophages in the bone marrow niche. Nature Communications, 15, 1090. (doi: 10.1038/s41467-024-45471-0) (PMID:38316788) (PMCID:PMC10844594)

Nyamondo, Kudzai and Wheadon, Helen ORCID logoORCID: https://orcid.org/0000-0001-9902-3170 (2024) Microenvironment alterations through time leading to myeloid malignancies. British Journal of Pharmacology, 181(2), pp. 283-294. (doi: 10.1111/bph.15924) (PMID:35844165)

Busch, Caroline, Mulholland, Theresa, Zagnoni, Michele, Dalby, Matthew ORCID logoORCID: https://orcid.org/0000-0002-0528-3359, Berry, Catherine ORCID logoORCID: https://orcid.org/0000-0002-6485-2187 and Wheadon, Helen ORCID logoORCID: https://orcid.org/0000-0001-9902-3170 (2023) Overcoming BCR::ABL1 dependent and independent survival mechanisms in chronic myeloid leukaemia using a multi-kinase targeting approach. Cell Communication and Signaling, 21, 342. (doi: 10.1186/s12964-023-01363-2) (PMID:38031192) (PMCID:PMC10685629)

Parry, Narissa, Busch, Caroline, Aßmann, Victoria, Cassels, Jennifer, Hair, Alan, Helgason, G. Vignir ORCID logoORCID: https://orcid.org/0000-0003-1616-132X, Wheadon, Helen ORCID logoORCID: https://orcid.org/0000-0001-9902-3170 and Copland, Mhairi ORCID logoORCID: https://orcid.org/0000-0002-7655-016X (2022) BH3 mimetics in combination with nilotinib or ponatinib represent a promising therapeutic strategy in blast phase chronic myeloid leukemia. Cell Death Discovery, 8, 457. (doi: 10.1038/s41420-022-01211-1) (PMID:36379918) (PMCID:PMC9666353)

Pancheva, Alexandrina, Wheadon, Helen ORCID logoORCID: https://orcid.org/0000-0001-9902-3170, Rogers, Simon ORCID logoORCID: https://orcid.org/0000-0003-3578-4477 and Otto, Thomas D. ORCID logoORCID: https://orcid.org/0000-0002-1246-7404 (2022) Using topic modeling to detect cellular crosstalk in scRNA-seq. PLoS Computational Biology, 18(4), e1009975. (doi: 10.1371/journal.pcbi.1009975) (PMID:35395014) (PMCID:PMC9064087)

Miari, Katerina E. ORCID logoORCID: https://orcid.org/0000-0003-3008-966X, Guzman, Monica L., Wheadon, Helen ORCID logoORCID: https://orcid.org/0000-0001-9902-3170 and Williams, Mark T. S. (2021) Macrophages in Acute Myeloid Leukaemia: significant players in therapy resistance and patient outcomes. Frontiers in Cell and Developmental Biology, 9, 692800. (doi: 10.3389/fcell.2021.692800) (PMID:34249942) (PMCID:PMC8264427)

Chantkran, Wittawat, Hsieh, Ya-Ching, Zheleva, Daniella, Frame, Sheelagh, Wheadon, Helen ORCID logoORCID: https://orcid.org/0000-0001-9902-3170 and Copland, Mhairi ORCID logoORCID: https://orcid.org/0000-0002-7655-016X (2021) Interrogation of novel CDK2/9 inhibitor fadraciclib (CYC065) as a potential therapeutic approach for AML. Cell Death Discovery, 7, 137. (doi: 10.1038/s41420-021-00496-y) (PMID:34112754) (PMCID:PMC8192769)

Parry, Narissa, Wheadon, Helen ORCID logoORCID: https://orcid.org/0000-0001-9902-3170 and Copland, Mhairi ORCID logoORCID: https://orcid.org/0000-0002-7655-016X (2021) The application of BH3 mimetics in myeloid leukemias. Cell Death and Disease, 12, 222. (doi: 10.1038/s41419-021-03500-6) (PMID:33637708) (PMCID:PMC7908010)

McAllister, Milly, Constancio, Vera, Patek, Samantha, Gan, Hao, Bailey, Peter ORCID logoORCID: https://orcid.org/0000-0002-0857-2041, Wheadon, Helen ORCID logoORCID: https://orcid.org/0000-0001-9902-3170, Underwood, Mark, Leung, Hing ORCID logoORCID: https://orcid.org/0000-0002-3933-3975 and Edwards, Joanne ORCID logoORCID: https://orcid.org/0000-0002-7192-6906 (2020) Inflammatory infiltration is associated with AR expression and poor prognosis in hormone naïve prostate cancer. Prostate, 80(15), pp. 1353-1364. (doi: 10.1002/pros.24064) (PMID:32846021)

Kinstrie, R. et al. (2020) CD93 is expressed on chronic myeloid leukemia stem cells and identifies a quiescent population which persists after tyrosine kinase inhibitor therapy. Leukemia, 34(6), pp. 1613-1625. (doi: 10.1038/s41375-019-0684-5) (PMID:31896780) (PMCID:PMC7272220)

Wheadon, Helen ORCID logoORCID: https://orcid.org/0000-0001-9902-3170 and Busch, Caroline (2019) Bone marrow niche crosses paths with BMPs: a road to protection and persistence in CML. Biochemical Society Transactions, 47(5), pp. 1307-1325. (doi: 10.1042/BST20190221) (PMID:31551354)

Toofan, Parto, Busch, Caroline, Morrison, Heather, O'Brien, Stephen, Jørgensen, Heather ORCID logoORCID: https://orcid.org/0000-0003-4663-4191, Copland, Mhairi ORCID logoORCID: https://orcid.org/0000-0002-7655-016X and Wheadon, Helen ORCID logoORCID: https://orcid.org/0000-0001-9902-3170 (2018) Chronic myeloid leukemia cells require the bone morphogenic protein pathway for cell cycle progression and self-renewal. Cell Death and Disease, 9, 927. (doi: 10.1038/s41419-018-0905-2) (PMID:30206237) (PMCID:PMC6134087)

Biggs, M. J.P. et al. (2017) The functional response of mesenchymal stem cells to electron-beam patterned elastomeric surfaces presenting micrometer to nanoscale heterogeneous rigidity. Advanced Materials, 29(39), 1702119. (doi: 10.1002/adma.201702119) (PMID:28861921)

Lewis, Natasha S., Lewis, Emily E.L., Mullin, Margaret, Wheadon, Helen ORCID logoORCID: https://orcid.org/0000-0001-9902-3170, Dalby, Matthew J. ORCID logoORCID: https://orcid.org/0000-0002-0528-3359 and Berry, Catherine C. ORCID logoORCID: https://orcid.org/0000-0002-6485-2187 (2017) Magnetically levitated mesenchymal stem cell spheroids cultured with a collagen gel maintain phenotype and quiescence. Journal of Tissue Engineering, 8, pp. 1-11. (doi: 10.1177/2041731417704428) (PMID:28616152) (PMCID:PMC5460809)

Toofan, Parto and Wheadon, Helen ORCID logoORCID: https://orcid.org/0000-0001-9902-3170 (2016) Role of the bone morphogenic protein pathway in developmental haemopoiesis and leukaemogenesis. Biochemical Society Transactions, 44(5), pp. 1455-1463. (doi: 10.1042/BST20160104) (PMID:27911727)

Lewis, Emily Elizabeth Louise, Wheadon, Helen ORCID logoORCID: https://orcid.org/0000-0001-9902-3170, Lewis, Natasha, Yang, Jingli, Mullin, Margaret, Hursthouse, Andrew, Stirling, David, Dalby, Matthew John ORCID logoORCID: https://orcid.org/0000-0002-0528-3359 and Berry, Catherine Cecilia ORCID logoORCID: https://orcid.org/0000-0002-6485-2187 (2016) A quiescent, regeneration-responsive tissue engineered mesenchymal stem cell bone marrow niche model via magnetic levitation. ACS Nano, 10(9), pp. 8346-8354. (doi: 10.1021/acsnano.6b02841) (PMID:27602872)

Irvine, D. A. et al. (2016) Deregulated hedgehog pathway signaling is inhibited by the smoothened antagonist LDE225 (Sonidegib) in chronic phase chronic myeloid leukaemia. Scientific Reports, 6, 25476. (doi: 10.1038/srep25476) (PMID:27157927) (PMCID:PMC4860619)

Ford, C. A. et al. (2015) Oncogenic properties of apoptotic tumor cells in aggressive B cell lymphoma. Current Biology, 25(5), pp. 577-588. (doi: 10.1016/j.cub.2014.12.059) (PMID:25702581) (PMCID:PMC4353688)

Kranc, K. R. et al. (2015) Acute loss of Cited2 impairs Nanog expression and decreases self-renewal of mouse embryonic stem cells. Stem Cells, 33(3), pp. 699-712. (doi: 10.1002/stem.1889) (PMID:25377420)

Middleton, O., Cosimo, E., Dobbin, E., McCaig, A.M., Clarke, C., Brant, A.M., Leach, M.T., Michie, A.M. ORCID logoORCID: https://orcid.org/0000-0002-5404-475X and Wheadon, H. ORCID logoORCID: https://orcid.org/0000-0001-9902-3170 (2015) Complement deficiencies limit CD20 monoclonal antibody treatment efficacy in CLL. Leukemia, 29(1), pp. 107-114. (doi: 10.1038/leu.2014.146) (PMID:24787488)

Gallipoli, Paolo, Cook, Amy, Rhodes, Susan ORCID logoORCID: https://orcid.org/0000-0001-6676-890X, Hopcroft, Lisa ORCID logoORCID: https://orcid.org/0000-0002-7022-1322, Wheadon, Helen ORCID logoORCID: https://orcid.org/0000-0001-9902-3170, Whetton, Anthony D., Jorgensen, Heather G. ORCID logoORCID: https://orcid.org/0000-0003-4663-4191, Bhatia, Ravi and Holyoake, Tessa L. (2014) JAK2/STAT5 inhibition by nilotinib with ruxolitinib contributes to the elimination of chronic phase CML CD34+ cells in vitro and in vivo. Blood, 124(9), pp. 1492-1501. (doi: 10.1182/blood-2013-12-545640) (PMID:24957147) (PMCID:PMC4148771)

Toofan, Parto, Irvine, David, Hopcroft, Lisa ORCID logoORCID: https://orcid.org/0000-0002-7022-1322, Copland, Mhairi ORCID logoORCID: https://orcid.org/0000-0002-7655-016X and Wheadon, Helen ORCID logoORCID: https://orcid.org/0000-0001-9902-3170 (2014) The role of the bone morphogenetic proteins in leukaemic stem cell persistence. Biochemical Society Transactions, 42(4), pp. 809-815. (doi: 10.1042/BST20140037)

Cosimo, E. et al. (2013) Inhibition of NF-κB-mediated signaling by the cyclin-dependent kinase inhibitor CR8 overcomes pro-survival stimuli to induce apoptosis in chronic lymphocytic leukemia cells. Clinical Cancer Research, 19(9), pp. 2393-2405. (doi: 10.1158/1078-0432.CCR-12-2170)

Sands, W.A., Copland, M. ORCID logoORCID: https://orcid.org/0000-0002-7655-016X and Wheadon, H. ORCID logoORCID: https://orcid.org/0000-0001-9902-3170 (2013) Targeting self-renewal pathways in myeloid malignancies. Cell Communication and Signaling, 11(33), (doi: 10.1186/1478-811X-11-33)

Tarafdar, A., Dobbin, E., Corrigan, P., Freeburn, R. and Wheadon, H. ORCID logoORCID: https://orcid.org/0000-0001-9902-3170 (2013) Canonical Wnt signaling promotes early hematopoietic progenitor formation and erythroid specification during embryonic stem cell differentiation. PLoS ONE, 8(11), e81030. (doi: 10.1371/journal.pone.0081030) (PMID:24324557) (PMCID:PMC3850021)

Wheadon, H. ORCID logoORCID: https://orcid.org/0000-0001-9902-3170, Ramsey, J.M., Dobbin, E., Dickson, G.J., Corrigan, P.M., Freeburn, R.W. and Thompson, A. (2011) Differential Hox expression in murine embryonic stem cell models of normal and malignant hematopoiesis. Stem Cells and Development, 20(8), pp. 1465-1476. (doi: 10.1089/scd.2010.0226)

Dobbin, E., Graham, C., Freeburn, R.W., Unwin, R.D., Griffiths, J.R., Pierce, A., Whetton, A.D. and Wheadon, H. ORCID logoORCID: https://orcid.org/0000-0001-9902-3170 (2010) Proteomic analysis reveals a novel mechanism induced by the leukemic oncogene Tel/PDGFRβ in stem cells: activation of the interferon response pathways. Stem Cell Research, 5(3), pp. 226-243. (doi: 10.1016/j.scr.2010.08.001)

Dobbin, E., Graham, C., Corrigan, P., Thomas, K., Freeburn, R. and Wheadon, H. ORCID logoORCID: https://orcid.org/0000-0001-9902-3170 (2009) Tel/PDGFRβ induces stem cell differentiation via the Ras/ERK and STAT5 signaling pathways. Experimental Hematology, 37(1), pp. 111-121. (doi: 10.1016/j.exphem.2008.09.012)

Corrigan, P.M., Dobbin, E., Freeburn, R.W. and Wheadon, H. ORCID logoORCID: https://orcid.org/0000-0001-9902-3170 (2009) Patterns of Wnt/Fzd/LRP gene expression during embryonic hematopoiesis. Stem Cells and Development, 18(5), pp. 759-771. (doi: 10.1089/scd.2008.0270)

Dobbin, E., Corrigan, P.M., Walsh, C.P., Welham, M.J., Freeburn, R.W. and Wheadon, H. ORCID logoORCID: https://orcid.org/0000-0001-9902-3170 (2008) Tel/PDGFRβ inhibits self-renewal and directs myelomonocytic differentiation of ES cells. Leukemia Research, 32(10), pp. 1554-1564. (doi: 10.1016/j.leukres.2008.02.007)

Paling, N.R.D., Wheadon, H. ORCID logoORCID: https://orcid.org/0000-0001-9902-3170, Bone, H.K. and Welham, M.J. (2004) Regulation of embryonic stem cell self-renewal by phosphoinositide 3-kinase-dependent signaling. Journal of Biological Chemistry, 279(46), pp. 48063-48070. (doi: 10.1074/jbc.M406467200)

Wheadon, H. ORCID logoORCID: https://orcid.org/0000-0001-9902-3170, Edmead, C. and Welham, M.J. (2003) Regulation of interleukin-3-induced substrate phosphorylation and cell survival by SHP-2 (Src-homology protein tyrosine phosphatase 2). Biochemical Journal, 376(1), pp. 147-157. (doi: 10.1042/BJ20031160)

Wheadon, H. ORCID logoORCID: https://orcid.org/0000-0001-9902-3170 and Welham, M.J. (2003) The coupling of TEL/PDGF R to distinct functional responses is modulated by the presence of cytokine: involvement of mitogen-activated protein kinases. Blood, 102(4), pp. 1480-1489. (doi: 10.1182/blood-2002-09-2974)

Wheadon, H. ORCID logoORCID: https://orcid.org/0000-0001-9902-3170, Paling, N.R.D. and Welham, M.J. (2002) Molecular interactions of SHP1 and SHP2 in IL-3-signalling. Cellular Signalling, 14(3), pp. 219-229. (doi: 10.1016/S0898-6568(01)00241-8)

Book Sections

Middleton, O., Wheadon, H. ORCID logoORCID: https://orcid.org/0000-0001-9902-3170 and Michie, A. ORCID logoORCID: https://orcid.org/0000-0002-5404-475X (2016) Classical complement pathway. In: Ratcliffe, M.J.H. (ed.) Encyclopedia of Immunobiology, 1st Edition. Elsevier: New York, NY. ISBN 9780123742797 (doi: 10.1016/B978-0-12-374279-7.02014-2)

Conference or Workshop Item

Zarou, M. M. et al. (2023) Leukaemia Exposure Alters the Transcriptional Profile and Function of Macrophages in the Bone Marrow Niche. 65th ASH Annual Meeting and Exposition, San Diego, California, USA, 09-12 Dec 2023. (doi: 10.1182/blood-2023-181630)

Horne, Gillian A. ORCID logoORCID: https://orcid.org/0000-0001-9741-7352, Morrison, Heather, Campbell, Victoria, Kinstrie, Ross, Cassels, Jennifer, Hair, Alan, Vetrie, David ORCID logoORCID: https://orcid.org/0000-0003-2075-4662, Wheadon, Helen ORCID logoORCID: https://orcid.org/0000-0001-9902-3170, Holyoake, Tessa L. and Copland, Mhairi ORCID logoORCID: https://orcid.org/0000-0002-7655-016X (2016) Notch Pathway Activation Targets Leukemic Stem Cells in Chronic-Phase Chronic Myeloid Leukemia (CP-CML). American Society of Hematology 58th Annual Meeting, San Diego, CA, USA, 3-6 Dec 2016.

Chaudhury, Shahzya S. ORCID logoORCID: https://orcid.org/0000-0002-6732-9949, Wheadon, Helen ORCID logoORCID: https://orcid.org/0000-0001-9902-3170, Gibson, Brenda and Keeshan, Karen ORCID logoORCID: https://orcid.org/0000-0001-7266-0890 (2016) The Bone Marrow Niche Distinguishes Young and Old Leukemia. 58th ASH Annual Meeting, San Diego, CA, USA, 3-6 Dec 2016.

Conference Proceedings

Rhodes, Susan ORCID logoORCID: https://orcid.org/0000-0001-6676-890X, Copland, Mhairi ORCID logoORCID: https://orcid.org/0000-0002-7655-016X, Hopcroft, Lisa ORCID logoORCID: https://orcid.org/0000-0002-7022-1322, Sayeski, Peter and Wheadon, Helen ORCID logoORCID: https://orcid.org/0000-0001-9902-3170 (2013) Identification of JAK2 dependent transcriptional regulators in CML. In: 42nd Annual Scientific Meeting of the ISEH – Society for Hematology and Stem Cells, Vienna, Austria, 22-25 Aug 2013, S47-S47.

This list was generated on Sat Jul 5 06:52:31 2025 BST.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • NC3R Partnership and Impact Award
    National Centre for the Replacement of Animals Research
    2025 - 2026
     
  • Targeting chemo-resistance mechanisms in chronic myeloid leukaemia.
    Beatson Cancer Charity
    2025 - 2027
     
  • MAINSTREAM: EPSRC Research and Partnership Hub for Health Technologies in Manufacturing Stem Cells
    Engineering and Physical Sciences Research Council
    2025 - 2031
     
  • Targeting MDM2 dimerisation as a novel therapeutic approach for acute myeloid leukaemia
    NHS Greater Glasgow and Clyde
    2024 - 2025
     
  • Engineering the bone marrow niche to control stem cell regulation, metastaticevolution and cancer dormancy
    Engineering and Physical Sciences Research Council
    2023 - 2028
     
  • Mechanobiology-based medicine - Phase 2
    Engineering and Physical Sciences Research Council
    2023 - 2028
     
  • Translating the CML-like Ph+ALL population into clinical practice
    Beatson Cancer Charity
    2023 - 2026
     
  • CRUK Centre Renewal 2021
    Cancer Research UK
    2022 - 2023
     
  • Mechanobiology-based medicine
    Engineering and Physical Sciences Research Council
    2021 - 2022
     
  • Evaluation of key Biomarkers for the prediction of successful treatment-free remission (TFR) in chronic myeloid leukaemia
    Cancer Research UK
    2021 - 2024
     
  • Validation of an artificial in vitro humanised 3D haemopoietic system to investigate haematological malignancies.
    National Centre for the Replacement of Animals Research
    2021 - 2024
     
  • Transcriptomic and proteomic variation of CML blast phase - a step towards novel targeted therapies
    Blood Cancer UK
    2021 - 2024
     
  • Engineered haematopoietic stem cell niches for disease modelling
    National Centre for the Replacement of Animals Research
    2020 - 2020
     
  • Exploring gene expression in individual CML stem cells to predict response to therapy in newly diagnosed patients
    Tenovus Scotland
    2016 - 2017
     
  • Single cell RNA sequencing on primative human leukaemic stem cell population to identify novel biomarkers involved in drug resistance and future immunotherapy
    Wellcome Trust
    2016 - 2018
     
  • Chronic Myeloid Leukaemia tyrosine kinase inhibitor response classification by quantitative RT-PCR
    NHS Greater Glasgow and Clyde
    2015 - 2016
     
  • Validating induced pluripotent stem cells (iPSC) as an acceptable model for pre-clinical drug screening in haematological malignancies
    Animal Free Research UK
    2014 - 2017
     
  • Investigation of JAK2 targets is myeloproliferative disorders
    Chief Scientist Office
    2013 - 2016
     
  • Wellcome Trust Scottish Translational Medicine and Therapeutics Initiative studentship
    Wellcome Trust
    2012 - 2016
     
  • Human embryonic stem cells as a model for understanding transcriptional regulation of Myeloproliferative neoplasms
    Blood Cancer UK
    2011 - 2013
     

Developmental Pathways Involved in Normal and Aberrant Haemopoietic Stem Cells