Professor Helen Wheadon

  • Professor of Stem Cell Regulation (Paul O'Gorman Leukaemia Research Centre)

telephone: 01413017893
email: Helen.Wheadon@glasgow.ac.uk

R323 Level 3, Leukaemia Research Centre, Gartnavel General Hospital, Glasgow G11 0YN

ORCID iDhttps://orcid.org/0000-0001-9902-3170

Publications

List by: Type | Date

Jump to: 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2011 | 2010 | 2009 | 2008 | 2004 | 2003 | 2002
Number of items: 30.

2020

McAllister, M. , Constancio, V. , Patek, S. , Gan, H. , Bailey, P. , Wheadon, H. , Underwood, M. , Leung, H. and Edwards, J. (2020) Inflammatory infiltration is associated with AR expression and poor prognosis in hormone naïve prostate cancer. Prostate, (doi: 10.1002/pros.24064) (PMID:32846021) (Early Online Publication)

Kinstrie, R. et al. (2020) CD93 is expressed on chronic myeloid leukemia stem cells and identifies a quiescent population which persists after tyrosine kinase inhibitor therapy. Leukemia, 34(6), pp. 1613-1625. (doi: 10.1038/s41375-019-0684-5) (PMID:31896780) (PMCID:PMC7272220)

2019

Wheadon, H. and Busch, C. (2019) Bone marrow niche crosses paths with BMPs: a road to protection and persistence in CML. Biochemical Society Transactions, 47(5), pp. 1307-1325. (doi: 10.1042/BST20190221) (PMID:31551354)

2018

Toofan, P. , Busch, C. , Morrison, H. , O'Brien, S. , Jørgensen, H. , Copland, M. and Wheadon, H. (2018) Chronic myeloid leukemia cells require the bone morphogenic protein pathway for cell cycle progression and self-renewal. Cell Death and Disease, 9, 927. (doi: 10.1038/s41419-018-0905-2) (PMID:30206237) (PMCID:PMC6134087)

2017

Biggs, M. J.P. et al. (2017) The functional response of mesenchymal stem cells to electron-beam patterned elastomeric surfaces presenting micrometer to nanoscale heterogeneous rigidity. Advanced Materials, 29(39), 1702119. (doi: 10.1002/adma.201702119) (PMID:28861921)

Lewis, N. S. , Lewis, E. E.L. , Mullin, M. , Wheadon, H. , Dalby, M. J. and Berry, C. C. (2017) Magnetically levitated mesenchymal stem cell spheroids cultured with a collagen gel maintain phenotype and quiescence. Journal of Tissue Engineering, 8, pp. 1-11. (doi: 10.1177/2041731417704428) (PMID:28616152) (PMCID:PMC5460809)

2016

Horne, G. A. , Morrison, H. , Campbell, V. , Kinstrie, R. , Cassels, J. , Hair, A. , Vetrie, D. , Wheadon, H. , Holyoake, T. L. and Copland, M. (2016) Notch Pathway Activation Targets Leukemic Stem Cells in Chronic-Phase Chronic Myeloid Leukemia (CP-CML). American Society of Hematology 58th Annual Meeting, San Diego, CA, USA, 3-6 Dec 2016.

Chaudhury, S. S. , Wheadon, H. , Gibson, B. and Keeshan, K. (2016) The Bone Marrow Niche Distinguishes Young and Old Leukemia. 58th ASH Annual Meeting, San Diego, CA, USA, 3-6 Dec 2016.

Toofan, P. and Wheadon, H. (2016) Role of the bone morphogenic protein pathway in developmental haemopoiesis and leukaemogenesis. Biochemical Society Transactions, 44(5), pp. 1455-1463. (doi: 10.1042/BST20160104) (PMID:27911727)

Lewis, E. E. L. , Wheadon, H. , Lewis, N. , Yang, J. , Mullin, M. , Hursthouse, A. , Stirling, D. , Dalby, M. J. and Berry, C. C. (2016) A quiescent, regeneration-responsive tissue engineered mesenchymal stem cell bone marrow niche model via magnetic levitation. ACS Nano, 10(9), pp. 8346-8354. (doi: 10.1021/acsnano.6b02841) (PMID:27602872)

Middleton, O. , Wheadon, H. and Michie, A. (2016) Classical complement pathway. In: Ratcliffe, M.J.H. (ed.) Encyclopedia of Immunobiology, 1st Edition. Elsevier: New York, NY. ISBN 9780123742797 (doi:10.1016/B978-0-12-374279-7.02014-2)

Irvine, D. A. et al. (2016) Deregulated hedgehog pathway signaling is inhibited by the smoothened antagonist LDE225 (Sonidegib) in chronic phase chronic myeloid leukaemia. Scientific Reports, 6, 25476. (doi: 10.1038/srep25476) (PMID:27157927) (PMCID:PMC4860619)

2015

Ford, C. A. et al. (2015) Oncogenic properties of apoptotic tumor cells in aggressive B cell lymphoma. Current Biology, 25(5), pp. 577-588. (doi: 10.1016/j.cub.2014.12.059) (PMID:25702581) (PMCID:PMC4353688)

Kranc, K. R. et al. (2015) Acute loss of Cited2 impairs Nanog expression and decreases self-renewal of mouse embryonic stem cells. Stem Cells, 33(3), pp. 699-712. (doi: 10.1002/stem.1889) (PMID:25377420)

Middleton, O. , Cosimo, E. , Dobbin, E. , McCaig, A.M. , Clarke, C. , Brant, A.M. , Leach, M.T. , Michie, A.M. and Wheadon, H. (2015) Complement deficiencies limit CD20 monoclonal antibody treatment efficacy in CLL. Leukemia, 29(1), pp. 107-114. (doi: 10.1038/leu.2014.146) (PMID:24787488)

2014

Gallipoli, P. , Cook, A. , Rhodes, S. , Hopcroft, L. , Wheadon, H. , Whetton, A. D. , Jorgensen, H. G. , Bhatia, R. and Holyoake, T. L. (2014) JAK2/STAT5 inhibition by nilotinib with ruxolitinib contributes to the elimination of chronic phase CML CD34+ cells in vitro and in vivo. Blood, 124(9), pp. 1492-1501. (doi: 10.1182/blood-2013-12-545640) (PMID:24957147) (PMCID:PMC4148771)

Toofan, P. , Irvine, D. , Hopcroft, L. , Copland, M. and Wheadon, H. (2014) The role of the bone morphogenetic proteins in leukaemic stem cell persistence. Biochemical Society Transactions, 42(4), pp. 809-815. (doi: 10.1042/BST20140037)

2013

Cosimo, E. et al. (2013) Inhibition of NF-κB-mediated signaling by the cyclin-dependent kinase inhibitor CR8 overcomes pro-survival stimuli to induce apoptosis in chronic lymphocytic leukemia cells. Clinical Cancer Research, 19(9), pp. 2393-2405. (doi: 10.1158/1078-0432.CCR-12-2170)

Rhodes, S. , Copland, M. , Hopcroft, L. , Sayeski, P. and Wheadon, H. (2013) Identification of JAK2 dependent transcriptional regulators in CML. In: 42nd Annual Scientific Meeting of the ISEH – Society for Hematology and Stem Cells, Vienna, Austria, 22-25 Aug 2013, S47-S47.

Sands, W.A. , Copland, M. and Wheadon, H. (2013) Targeting self-renewal pathways in myeloid malignancies. Cell Communication and Signaling, 11(33), (doi: 10.1186/1478-811X-11-33)

Tarafdar, A. , Dobbin, E. , Corrigan, P. , Freeburn, R. and Wheadon, H. (2013) Canonical Wnt signaling promotes early hematopoietic progenitor formation and erythroid specification during embryonic stem cell differentiation. PLoS ONE, 8(11), e81030. (doi: 10.1371/journal.pone.0081030) (PMID:24324557) (PMCID:PMC3850021)

2011

Wheadon, H. , Ramsey, J.M. , Dobbin, E. , Dickson, G.J. , Corrigan, P.M. , Freeburn, R.W. and Thompson, A. (2011) Differential Hox expression in murine embryonic stem cell models of normal and malignant hematopoiesis. Stem Cells and Development, 20(8), pp. 1465-1476. (doi: 10.1089/scd.2010.0226)

2010

Dobbin, E. , Graham, C. , Freeburn, R.W. , Unwin, R.D. , Griffiths, J.R. , Pierce, A. , Whetton, A.D. and Wheadon, H. (2010) Proteomic analysis reveals a novel mechanism induced by the leukemic oncogene Tel/PDGFRβ in stem cells: activation of the interferon response pathways. Stem Cell Research, 5(3), pp. 226-243. (doi: 10.1016/j.scr.2010.08.001)

2009

Dobbin, E. , Graham, C. , Corrigan, P. , Thomas, K. , Freeburn, R. and Wheadon, H. (2009) Tel/PDGFRβ induces stem cell differentiation via the Ras/ERK and STAT5 signaling pathways. Experimental Hematology, 37(1), pp. 111-121. (doi: 10.1016/j.exphem.2008.09.012)

Corrigan, P.M. , Dobbin, E. , Freeburn, R.W. and Wheadon, H. (2009) Patterns of Wnt/Fzd/LRP gene expression during embryonic hematopoiesis. Stem Cells and Development, 18(5), pp. 759-771. (doi: 10.1089/scd.2008.0270)

2008

Dobbin, E. , Corrigan, P.M. , Walsh, C.P. , Welham, M.J. , Freeburn, R.W. and Wheadon, H. (2008) Tel/PDGFRβ inhibits self-renewal and directs myelomonocytic differentiation of ES cells. Leukemia Research, 32(10), pp. 1554-1564. (doi: 10.1016/j.leukres.2008.02.007)

2004

Paling, N.R.D. , Wheadon, H. , Bone, H.K. and Welham, M.J. (2004) Regulation of embryonic stem cell self-renewal by phosphoinositide 3-kinase-dependent signaling. Journal of Biological Chemistry, 279(46), pp. 48063-48070. (doi: 10.1074/jbc.M406467200)

2003

Wheadon, H. , Edmead, C. and Welham, M.J. (2003) Regulation of interleukin-3-induced substrate phosphorylation and cell survival by SHP-2 (Src-homology protein tyrosine phosphatase 2). Biochemical Journal, 376(1), pp. 147-157. (doi: 10.1042/BJ20031160)

Wheadon, H. and Welham, M.J. (2003) The coupling of TEL/PDGF R to distinct functional responses is modulated by the presence of cytokine: involvement of mitogen-activated protein kinases. Blood, 102(4), pp. 1480-1489. (doi: 10.1182/blood-2002-09-2974)

2002

Wheadon, H. , Paling, N.R.D. and Welham, M.J. (2002) Molecular interactions of SHP1 and SHP2 in IL-3-signalling. Cellular Signalling, 14(3), pp. 219-229. (doi: 10.1016/S0898-6568(01)00241-8)

This list was generated on Tue Sep 22 23:52:24 2020 BST.
Number of items: 30.

Articles

McAllister, M. , Constancio, V. , Patek, S. , Gan, H. , Bailey, P. , Wheadon, H. , Underwood, M. , Leung, H. and Edwards, J. (2020) Inflammatory infiltration is associated with AR expression and poor prognosis in hormone naïve prostate cancer. Prostate, (doi: 10.1002/pros.24064) (PMID:32846021) (Early Online Publication)

Kinstrie, R. et al. (2020) CD93 is expressed on chronic myeloid leukemia stem cells and identifies a quiescent population which persists after tyrosine kinase inhibitor therapy. Leukemia, 34(6), pp. 1613-1625. (doi: 10.1038/s41375-019-0684-5) (PMID:31896780) (PMCID:PMC7272220)

Wheadon, H. and Busch, C. (2019) Bone marrow niche crosses paths with BMPs: a road to protection and persistence in CML. Biochemical Society Transactions, 47(5), pp. 1307-1325. (doi: 10.1042/BST20190221) (PMID:31551354)

Toofan, P. , Busch, C. , Morrison, H. , O'Brien, S. , Jørgensen, H. , Copland, M. and Wheadon, H. (2018) Chronic myeloid leukemia cells require the bone morphogenic protein pathway for cell cycle progression and self-renewal. Cell Death and Disease, 9, 927. (doi: 10.1038/s41419-018-0905-2) (PMID:30206237) (PMCID:PMC6134087)

Biggs, M. J.P. et al. (2017) The functional response of mesenchymal stem cells to electron-beam patterned elastomeric surfaces presenting micrometer to nanoscale heterogeneous rigidity. Advanced Materials, 29(39), 1702119. (doi: 10.1002/adma.201702119) (PMID:28861921)

Lewis, N. S. , Lewis, E. E.L. , Mullin, M. , Wheadon, H. , Dalby, M. J. and Berry, C. C. (2017) Magnetically levitated mesenchymal stem cell spheroids cultured with a collagen gel maintain phenotype and quiescence. Journal of Tissue Engineering, 8, pp. 1-11. (doi: 10.1177/2041731417704428) (PMID:28616152) (PMCID:PMC5460809)

Toofan, P. and Wheadon, H. (2016) Role of the bone morphogenic protein pathway in developmental haemopoiesis and leukaemogenesis. Biochemical Society Transactions, 44(5), pp. 1455-1463. (doi: 10.1042/BST20160104) (PMID:27911727)

Lewis, E. E. L. , Wheadon, H. , Lewis, N. , Yang, J. , Mullin, M. , Hursthouse, A. , Stirling, D. , Dalby, M. J. and Berry, C. C. (2016) A quiescent, regeneration-responsive tissue engineered mesenchymal stem cell bone marrow niche model via magnetic levitation. ACS Nano, 10(9), pp. 8346-8354. (doi: 10.1021/acsnano.6b02841) (PMID:27602872)

Irvine, D. A. et al. (2016) Deregulated hedgehog pathway signaling is inhibited by the smoothened antagonist LDE225 (Sonidegib) in chronic phase chronic myeloid leukaemia. Scientific Reports, 6, 25476. (doi: 10.1038/srep25476) (PMID:27157927) (PMCID:PMC4860619)

Ford, C. A. et al. (2015) Oncogenic properties of apoptotic tumor cells in aggressive B cell lymphoma. Current Biology, 25(5), pp. 577-588. (doi: 10.1016/j.cub.2014.12.059) (PMID:25702581) (PMCID:PMC4353688)

Kranc, K. R. et al. (2015) Acute loss of Cited2 impairs Nanog expression and decreases self-renewal of mouse embryonic stem cells. Stem Cells, 33(3), pp. 699-712. (doi: 10.1002/stem.1889) (PMID:25377420)

Middleton, O. , Cosimo, E. , Dobbin, E. , McCaig, A.M. , Clarke, C. , Brant, A.M. , Leach, M.T. , Michie, A.M. and Wheadon, H. (2015) Complement deficiencies limit CD20 monoclonal antibody treatment efficacy in CLL. Leukemia, 29(1), pp. 107-114. (doi: 10.1038/leu.2014.146) (PMID:24787488)

Gallipoli, P. , Cook, A. , Rhodes, S. , Hopcroft, L. , Wheadon, H. , Whetton, A. D. , Jorgensen, H. G. , Bhatia, R. and Holyoake, T. L. (2014) JAK2/STAT5 inhibition by nilotinib with ruxolitinib contributes to the elimination of chronic phase CML CD34+ cells in vitro and in vivo. Blood, 124(9), pp. 1492-1501. (doi: 10.1182/blood-2013-12-545640) (PMID:24957147) (PMCID:PMC4148771)

Toofan, P. , Irvine, D. , Hopcroft, L. , Copland, M. and Wheadon, H. (2014) The role of the bone morphogenetic proteins in leukaemic stem cell persistence. Biochemical Society Transactions, 42(4), pp. 809-815. (doi: 10.1042/BST20140037)

Cosimo, E. et al. (2013) Inhibition of NF-κB-mediated signaling by the cyclin-dependent kinase inhibitor CR8 overcomes pro-survival stimuli to induce apoptosis in chronic lymphocytic leukemia cells. Clinical Cancer Research, 19(9), pp. 2393-2405. (doi: 10.1158/1078-0432.CCR-12-2170)

Sands, W.A. , Copland, M. and Wheadon, H. (2013) Targeting self-renewal pathways in myeloid malignancies. Cell Communication and Signaling, 11(33), (doi: 10.1186/1478-811X-11-33)

Tarafdar, A. , Dobbin, E. , Corrigan, P. , Freeburn, R. and Wheadon, H. (2013) Canonical Wnt signaling promotes early hematopoietic progenitor formation and erythroid specification during embryonic stem cell differentiation. PLoS ONE, 8(11), e81030. (doi: 10.1371/journal.pone.0081030) (PMID:24324557) (PMCID:PMC3850021)

Wheadon, H. , Ramsey, J.M. , Dobbin, E. , Dickson, G.J. , Corrigan, P.M. , Freeburn, R.W. and Thompson, A. (2011) Differential Hox expression in murine embryonic stem cell models of normal and malignant hematopoiesis. Stem Cells and Development, 20(8), pp. 1465-1476. (doi: 10.1089/scd.2010.0226)

Dobbin, E. , Graham, C. , Freeburn, R.W. , Unwin, R.D. , Griffiths, J.R. , Pierce, A. , Whetton, A.D. and Wheadon, H. (2010) Proteomic analysis reveals a novel mechanism induced by the leukemic oncogene Tel/PDGFRβ in stem cells: activation of the interferon response pathways. Stem Cell Research, 5(3), pp. 226-243. (doi: 10.1016/j.scr.2010.08.001)

Dobbin, E. , Graham, C. , Corrigan, P. , Thomas, K. , Freeburn, R. and Wheadon, H. (2009) Tel/PDGFRβ induces stem cell differentiation via the Ras/ERK and STAT5 signaling pathways. Experimental Hematology, 37(1), pp. 111-121. (doi: 10.1016/j.exphem.2008.09.012)

Corrigan, P.M. , Dobbin, E. , Freeburn, R.W. and Wheadon, H. (2009) Patterns of Wnt/Fzd/LRP gene expression during embryonic hematopoiesis. Stem Cells and Development, 18(5), pp. 759-771. (doi: 10.1089/scd.2008.0270)

Dobbin, E. , Corrigan, P.M. , Walsh, C.P. , Welham, M.J. , Freeburn, R.W. and Wheadon, H. (2008) Tel/PDGFRβ inhibits self-renewal and directs myelomonocytic differentiation of ES cells. Leukemia Research, 32(10), pp. 1554-1564. (doi: 10.1016/j.leukres.2008.02.007)

Paling, N.R.D. , Wheadon, H. , Bone, H.K. and Welham, M.J. (2004) Regulation of embryonic stem cell self-renewal by phosphoinositide 3-kinase-dependent signaling. Journal of Biological Chemistry, 279(46), pp. 48063-48070. (doi: 10.1074/jbc.M406467200)

Wheadon, H. , Edmead, C. and Welham, M.J. (2003) Regulation of interleukin-3-induced substrate phosphorylation and cell survival by SHP-2 (Src-homology protein tyrosine phosphatase 2). Biochemical Journal, 376(1), pp. 147-157. (doi: 10.1042/BJ20031160)

Wheadon, H. and Welham, M.J. (2003) The coupling of TEL/PDGF R to distinct functional responses is modulated by the presence of cytokine: involvement of mitogen-activated protein kinases. Blood, 102(4), pp. 1480-1489. (doi: 10.1182/blood-2002-09-2974)

Wheadon, H. , Paling, N.R.D. and Welham, M.J. (2002) Molecular interactions of SHP1 and SHP2 in IL-3-signalling. Cellular Signalling, 14(3), pp. 219-229. (doi: 10.1016/S0898-6568(01)00241-8)

Book Sections

Middleton, O. , Wheadon, H. and Michie, A. (2016) Classical complement pathway. In: Ratcliffe, M.J.H. (ed.) Encyclopedia of Immunobiology, 1st Edition. Elsevier: New York, NY. ISBN 9780123742797 (doi:10.1016/B978-0-12-374279-7.02014-2)

Conference or Workshop Item

Horne, G. A. , Morrison, H. , Campbell, V. , Kinstrie, R. , Cassels, J. , Hair, A. , Vetrie, D. , Wheadon, H. , Holyoake, T. L. and Copland, M. (2016) Notch Pathway Activation Targets Leukemic Stem Cells in Chronic-Phase Chronic Myeloid Leukemia (CP-CML). American Society of Hematology 58th Annual Meeting, San Diego, CA, USA, 3-6 Dec 2016.

Chaudhury, S. S. , Wheadon, H. , Gibson, B. and Keeshan, K. (2016) The Bone Marrow Niche Distinguishes Young and Old Leukemia. 58th ASH Annual Meeting, San Diego, CA, USA, 3-6 Dec 2016.

Conference Proceedings

Rhodes, S. , Copland, M. , Hopcroft, L. , Sayeski, P. and Wheadon, H. (2013) Identification of JAK2 dependent transcriptional regulators in CML. In: 42nd Annual Scientific Meeting of the ISEH – Society for Hematology and Stem Cells, Vienna, Austria, 22-25 Aug 2013, S47-S47.

This list was generated on Tue Sep 22 23:52:24 2020 BST.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Engineered haematopoietic stem cell niches for disease modelling
    National Centre for the Replacement of Animals Research
    2020 - 2020
     
  • Exploring gene expression in individual CML stem cells to predict response to therapy in newly diagnosed patients
    Tenovus Scotland
    2016 - 2017
     
  • Single cell RNA sequencing on primative human leukaemic stem cell population to identify novel biomarkers involved in drug resistance and future immunotherapy
    Wellcome Trust
    2016 - 2018
     
  • Chronic Myeloid Leukaemia tyrosine kinase inhibitor response classification by quantitative RT-PCR
    NHS Greater Glasgow and Clyde
    2015 - 2016
     
  • Validating induced pluripotent stem cells (iPSC) as an acceptable model for pre-clinical drug screening in haematological malignancies
    Animal Free Research UK
    2014 - 2017
     
  • Investigation of JAK2 targets is myeloproliferative disorders
    Chief Scientist Office
    2013 - 2016
     
  • Wellcome Trust Scottish Translational Medicine and Therapeutics Initiative studentship
    Wellcome Trust
    2012 - 2016
     
  • Human embryonic stem cells as a model for understanding transcriptional regulation of Myeloproliferative neoplasms
    Bloodwise
    2011 - 2013