2025

Weir, Daniel, Bentley-Abbot, Calum, McCowan, Jack, Loney, Colin ORCID: https://orcid.org/0000-0002-0508-1781, Roberts, Edward ORCID: https://orcid.org/0000-0002-8229-1715 and Hutchinson, Edward ORCID: https://orcid.org/0000-0003-3673-9096 (2025) Induction of tunnelling nanotube-like structures by influenza A viruses requires the onset of apoptosis. PLoS Pathogens, 21(6), e1013191. (doi: 10.1371/journal.ppat.1013191) (Early Online Publication)

2024

Hargrave, Kerrie E., Worrell, Julie C. ORCID: https://orcid.org/0000-0001-7754-1364, Pirillo, Chiara, Brennan, Euan, Masdefiol Garriga, Andreu ORCID: https://orcid.org/0000-0002-2094-3001, Gray, Joshua I., Purnell, Thomas, Roberts, Edward W. ORCID: https://orcid.org/0000-0002-8229-1715 and MacLeod, Megan K.L. ORCID: https://orcid.org/0000-0003-1843-8580 (2024) Lung influenza virus specific memory CD4 T cell location and optimal cytokine production are dependent on interactions with lung antigen-presenting cells. Mucosal Immunology, 17(5), pp. 843-857. (doi: 10.1016/j.mucimm.2024.06.001) (PMID:38851589) (PMCID:PMC11464401)

Kumar, S. et al. (2024) Specialized Tfh cell subsets driving type-1 and type-21 humoral responses in lymphoid tissue. Cell Discovery, 10, 64. (doi: 10.1038/s41421-024-00681-0) (PMID:38834551) (PMCID:PMC11150427)

Bentley-Abbot, Calum, Heslop, Rhiannon, Pirillo, Chiara, Chandrasegaran, Praveena, McConnell, Gail, Roberts, Ed ORCID: https://orcid.org/0000-0002-8229-1715, Hutchinson, Edward ORCID: https://orcid.org/0000-0003-3673-9096 and MacLeod, Annette ORCID: https://orcid.org/0000-0002-0150-5049 (2024) An easy to use tool for the analysis of subcellular mRNA transcript colocalisation in smFISH data. Scientific Reports, 14, 8348. (doi: 10.1038/s41598-024-58641-3) (PMID:38594373) (PMCID:PMC11004122)

Mahmood, M. et al. (2024) Mitochondrial DNA mutations drive aerobic glycolysis to enhance checkpoint blockade response in melanoma. Nature Cancer, (doi: 10.1038/s43018-023-00721-w) (PMID:38286828) (Early Online Publication)

2023

Young, Alexander L., Lorimer, Tara, Al-Khalidi, Sarwah K. and Roberts, Edward W. ORCID: https://orcid.org/0000-0002-8229-1715 (2023) De novo priming: driver of immunotherapy responses or epiphenomenon? Essays In Biochemistry, 67(6), pp. 929-939. (doi: 10.1042/EBC20220244) (PMID:37139854) (PMCID:PMC10539938)

Pirillo, C. et al. (2023) Cotransfer of antigen and contextual information harmonizes peripheral and lymph node conventional dendritic cell activation. Science Immunology, 8(85), eadg8249. (doi: 10.1126/sciimmunol.adg8249) (PMID:37478193) (PMCID:PMC7616026)

2022

Sims, A. et al. (2022) Superinfection exclusion creates spatially distinct influenza virus populations. PLoS Biology, 21(2), e3001941. (doi: 10.1371/journal.pbio.3001941) (PMID:36757937) (PMCID:PMC9910727)

Leslie, J. et al. (2022) CXCR2 inhibition enables NASH-HCC immunotherapy. Gut, 71(10), pp. 2093-2106. (doi: 10.1136/gutjnl-2021-326259) (PMID:35477863) (PMCID:PMC9484388)

Bravo-Blas, Alberto, Pirillo, Chiara, Shergold, Amy, Andrusaite, Anna and Roberts, Edward W. ORCID: https://orcid.org/0000-0002-8229-1715 (2022) Think global but act local: Tuning the dendritic cell response in cancer. International Journal of Biochemistry and Cell Biology, 147, 106227. (doi: 10.1016/j.biocel.2022.106227) (PMID:35605877)

Pirillo, C. et al. (2022) Metalloproteinase inhibition reduces AML growth, prevents stem cell loss and improves chemotherapy effectiveness. Blood Advances, 6(10), pp. 3126-3141. (doi: 10.1182/bloodadvances.2021004321) (PMID:35157757) (PMCID:PMC9131921)

Devlin, Ryan and Roberts, Ed ORCID: https://orcid.org/0000-0002-8229-1715 (2022) Building a healthy mouse model ecosystem to interrogate cancer biology. Disease Models and Mechanisms, 15(9), dmm049795. (doi: 10.1242/dmm.049795) (PMID:36098988) (PMCID:PMC9509886)

2021

Ntala, C. et al. (2021) Analysis of prostate cancer tumor microenvironment identifies reduced stromal CD4 effector T-cell infiltration in tumors with pelvic nodal metastasis. European Urology Open Science, 29, pp. 19-29. (doi: 10.1016/j.euros.2021.05.001) (PMID:34337530) (PMCID:PMC8317840)

2019

Binnewies, M. et al. (2019) Unleashing type-2 dendritic cells to drive protective antitumor CD4+ T cell immunity. Cell, 177(3), 556-571.e16. (doi: 10.1016/j.cell.2019.02.005) (PMID:30955881) (PMCID:PMC6954108)

2018

Morrissey, Meghan A., Williamson, Adam P., Steinbach, Adriana M., Roberts, Edward W. ORCID: https://orcid.org/0000-0002-8229-1715, Kern, Nadja, Headley, Mark B. and Vale, Ronald D. (2018) Chimeric antigen receptors that trigger phagocytosis. eLife, 7, e36688. (doi: 10.7554/eLife.36688.001) (PMID:29862966) (PMCID:PMC6008046)

Binnewies, M. et al. (2018) Understanding the tumor immune microenvironment (TIME) for effective therapy. Nature Medicine, 24(5), pp. 541-550. (doi: 10.1038/s41591-018-0014-x) (PMID:29686425) (PMCID:PMC5998822)

Denton, Alice E., Roberts, Edward W. ORCID: https://orcid.org/0000-0002-8229-1715 and Fearon, Douglas T. (2018) Stromal cells in the tumor microenvironment. In: Owens, Benjamin M.J. and Lakins, Matthew A. (eds.) Stromal Immunology. Series: Advances in Experimental Medicine and Biology, 1060. Springer, pp. 99-114. ISBN 9783319781259 (doi: 10.1007/978-3-319-78127-3_6)

2017

Wong, Pamela T., Roberts, Edward W. ORCID: https://orcid.org/0000-0002-8229-1715, Tang, Shengzhuang, Mukherjee, Jhindan, Cannon, Jayme, Nip, Alyssa J., Corbin, Kaitlin, Krummel, Matthew F. and Choi, Seok Ki (2017) Control of an unusual photo-claisen rearrangement in coumarin caged tamoxifen through an extended spacer. ACS Chemical Biology, 12(4), pp. 1001-1010. (doi: 10.1021/acschembio.6b00999) (PMID:28191924) (PMCID:PMC5404426)

2016

Flint, Thomas R., Janowitz, Tobias, Connell, Claire M., Roberts, Edward W. ORCID: https://orcid.org/0000-0002-8229-1715, Denton, Alice E., Coll, Anthony P., Jodrell, Duncan I. and Fearon, Douglas T. (2016) Tumor-induced IL-6 reprograms host metabolism to suppress anti-tumor immunity. Cell Metabolism, 24(5), pp. 672-684. (doi: 10.1016/j.cmet.2016.10.010) (PMID:27829137) (PMCID:PMC5106372)

Roberts, Edward W. ORCID: https://orcid.org/0000-0002-8229-1715, Broz, Miranda L., Binnewies, Mikhail, Headley, Mark B., Nelson, Amanda E., Wolf, Denise M., Kaisho, Tsuneyasu, Bogunovic, Dusan, Bhardwaj, Nina and Krummel, Matthew F. (2016) Critical role for CD103 + /CD141 + dendritic cells bearing CCR7 for tumor antigen trafficking and priming of T cell immunity in melanoma. Cancer Cell, 30(2), pp. 324-336. (doi: 10.1016/j.ccell.2016.06.003) (PMID:27424807) (PMCID:PMC5374862)

Headley, Mark B., Bins, Adriaan, Nip, Alyssa, Roberts, Edward W. ORCID: https://orcid.org/0000-0002-8229-1715, Looney, Mark R., Gerard, Audrey and Krummel, Matthew F. (2016) Visualization of immediate immune responses to pioneer metastatic cells in the lung. Nature, 531(7595), pp. 513-517. (doi: 10.1038/nature16985) (PMID:26982733) (PMCID:PMC4892380)

Roberts, E.W. ORCID: https://orcid.org/0000-0002-8229-1715, Denton, A.E. and Fearon, D.T. (2016) Roles of stromal cells in the immune system. In: Bradshaw, Ralph A. and Stahl, Philip D. (eds.) Encyclopedia of Cell Biology. Elsevier, pp. 616-623. ISBN 9780123947963 (doi: 10.1016/B978-0-12-394447-4.30079-7)

2014

Denton, A.E., Roberts, E.W. ORCID: https://orcid.org/0000-0002-8229-1715, Linterman, M.A. and Fearon, D.T. (2014) Fibroblastic reticular cells of the lymph node are required for retention of resting but not activated CD8+ T cells. Proceedings of the National Academy of Sciences of the United States of America, 111(33), pp. 12139-12144. (doi: 10.1073/pnas.1412910111) (PMID:25092322) (PMCID:PMC4143042)

2013

Feig, C. et al. (2013) Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer. Proceedings of the National Academy of Sciences of the United States of America, 110(50), pp. 20212-20217. (doi: 10.1073/pnas.1320318110) (PMID:24277834) (PMCID:PMC3864274)

Roberts, E. W. et al. (2013) Depletion of stromal cells expressing fibroblast activation protein-α from skeletal muscle and bone marrow results in cachexia and anemia. Journal of Experimental Medicine, 210(6), pp. 1137-1151. (doi: 10.1084/jem.20122344) (PMID:23712428) (PMCID:PMC3674708)

Articles

Weir, Daniel, Bentley-Abbot, Calum, McCowan, Jack, Loney, Colin ORCID: https://orcid.org/0000-0002-0508-1781, Roberts, Edward ORCID: https://orcid.org/0000-0002-8229-1715 and Hutchinson, Edward ORCID: https://orcid.org/0000-0003-3673-9096 (2025) Induction of tunnelling nanotube-like structures by influenza A viruses requires the onset of apoptosis. PLoS Pathogens, 21(6), e1013191. (doi: 10.1371/journal.ppat.1013191) (Early Online Publication)

Hargrave, Kerrie E., Worrell, Julie C. ORCID: https://orcid.org/0000-0001-7754-1364, Pirillo, Chiara, Brennan, Euan, Masdefiol Garriga, Andreu ORCID: https://orcid.org/0000-0002-2094-3001, Gray, Joshua I., Purnell, Thomas, Roberts, Edward W. ORCID: https://orcid.org/0000-0002-8229-1715 and MacLeod, Megan K.L. ORCID: https://orcid.org/0000-0003-1843-8580 (2024) Lung influenza virus specific memory CD4 T cell location and optimal cytokine production are dependent on interactions with lung antigen-presenting cells. Mucosal Immunology, 17(5), pp. 843-857. (doi: 10.1016/j.mucimm.2024.06.001) (PMID:38851589) (PMCID:PMC11464401)

Kumar, S. et al. (2024) Specialized Tfh cell subsets driving type-1 and type-21 humoral responses in lymphoid tissue. Cell Discovery, 10, 64. (doi: 10.1038/s41421-024-00681-0) (PMID:38834551) (PMCID:PMC11150427)

Bentley-Abbot, Calum, Heslop, Rhiannon, Pirillo, Chiara, Chandrasegaran, Praveena, McConnell, Gail, Roberts, Ed ORCID: https://orcid.org/0000-0002-8229-1715, Hutchinson, Edward ORCID: https://orcid.org/0000-0003-3673-9096 and MacLeod, Annette ORCID: https://orcid.org/0000-0002-0150-5049 (2024) An easy to use tool for the analysis of subcellular mRNA transcript colocalisation in smFISH data. Scientific Reports, 14, 8348. (doi: 10.1038/s41598-024-58641-3) (PMID:38594373) (PMCID:PMC11004122)

Mahmood, M. et al. (2024) Mitochondrial DNA mutations drive aerobic glycolysis to enhance checkpoint blockade response in melanoma. Nature Cancer, (doi: 10.1038/s43018-023-00721-w) (PMID:38286828) (Early Online Publication)

Young, Alexander L., Lorimer, Tara, Al-Khalidi, Sarwah K. and Roberts, Edward W. ORCID: https://orcid.org/0000-0002-8229-1715 (2023) De novo priming: driver of immunotherapy responses or epiphenomenon? Essays In Biochemistry, 67(6), pp. 929-939. (doi: 10.1042/EBC20220244) (PMID:37139854) (PMCID:PMC10539938)

Pirillo, C. et al. (2023) Cotransfer of antigen and contextual information harmonizes peripheral and lymph node conventional dendritic cell activation. Science Immunology, 8(85), eadg8249. (doi: 10.1126/sciimmunol.adg8249) (PMID:37478193) (PMCID:PMC7616026)

Sims, A. et al. (2022) Superinfection exclusion creates spatially distinct influenza virus populations. PLoS Biology, 21(2), e3001941. (doi: 10.1371/journal.pbio.3001941) (PMID:36757937) (PMCID:PMC9910727)

Leslie, J. et al. (2022) CXCR2 inhibition enables NASH-HCC immunotherapy. Gut, 71(10), pp. 2093-2106. (doi: 10.1136/gutjnl-2021-326259) (PMID:35477863) (PMCID:PMC9484388)

Bravo-Blas, Alberto, Pirillo, Chiara, Shergold, Amy, Andrusaite, Anna and Roberts, Edward W. ORCID: https://orcid.org/0000-0002-8229-1715 (2022) Think global but act local: Tuning the dendritic cell response in cancer. International Journal of Biochemistry and Cell Biology, 147, 106227. (doi: 10.1016/j.biocel.2022.106227) (PMID:35605877)

Pirillo, C. et al. (2022) Metalloproteinase inhibition reduces AML growth, prevents stem cell loss and improves chemotherapy effectiveness. Blood Advances, 6(10), pp. 3126-3141. (doi: 10.1182/bloodadvances.2021004321) (PMID:35157757) (PMCID:PMC9131921)

Devlin, Ryan and Roberts, Ed ORCID: https://orcid.org/0000-0002-8229-1715 (2022) Building a healthy mouse model ecosystem to interrogate cancer biology. Disease Models and Mechanisms, 15(9), dmm049795. (doi: 10.1242/dmm.049795) (PMID:36098988) (PMCID:PMC9509886)

Ntala, C. et al. (2021) Analysis of prostate cancer tumor microenvironment identifies reduced stromal CD4 effector T-cell infiltration in tumors with pelvic nodal metastasis. European Urology Open Science, 29, pp. 19-29. (doi: 10.1016/j.euros.2021.05.001) (PMID:34337530) (PMCID:PMC8317840)

Binnewies, M. et al. (2019) Unleashing type-2 dendritic cells to drive protective antitumor CD4+ T cell immunity. Cell, 177(3), 556-571.e16. (doi: 10.1016/j.cell.2019.02.005) (PMID:30955881) (PMCID:PMC6954108)

Morrissey, Meghan A., Williamson, Adam P., Steinbach, Adriana M., Roberts, Edward W. ORCID: https://orcid.org/0000-0002-8229-1715, Kern, Nadja, Headley, Mark B. and Vale, Ronald D. (2018) Chimeric antigen receptors that trigger phagocytosis. eLife, 7, e36688. (doi: 10.7554/eLife.36688.001) (PMID:29862966) (PMCID:PMC6008046)

Binnewies, M. et al. (2018) Understanding the tumor immune microenvironment (TIME) for effective therapy. Nature Medicine, 24(5), pp. 541-550. (doi: 10.1038/s41591-018-0014-x) (PMID:29686425) (PMCID:PMC5998822)

Wong, Pamela T., Roberts, Edward W. ORCID: https://orcid.org/0000-0002-8229-1715, Tang, Shengzhuang, Mukherjee, Jhindan, Cannon, Jayme, Nip, Alyssa J., Corbin, Kaitlin, Krummel, Matthew F. and Choi, Seok Ki (2017) Control of an unusual photo-claisen rearrangement in coumarin caged tamoxifen through an extended spacer. ACS Chemical Biology, 12(4), pp. 1001-1010. (doi: 10.1021/acschembio.6b00999) (PMID:28191924) (PMCID:PMC5404426)

Flint, Thomas R., Janowitz, Tobias, Connell, Claire M., Roberts, Edward W. ORCID: https://orcid.org/0000-0002-8229-1715, Denton, Alice E., Coll, Anthony P., Jodrell, Duncan I. and Fearon, Douglas T. (2016) Tumor-induced IL-6 reprograms host metabolism to suppress anti-tumor immunity. Cell Metabolism, 24(5), pp. 672-684. (doi: 10.1016/j.cmet.2016.10.010) (PMID:27829137) (PMCID:PMC5106372)

Roberts, Edward W. ORCID: https://orcid.org/0000-0002-8229-1715, Broz, Miranda L., Binnewies, Mikhail, Headley, Mark B., Nelson, Amanda E., Wolf, Denise M., Kaisho, Tsuneyasu, Bogunovic, Dusan, Bhardwaj, Nina and Krummel, Matthew F. (2016) Critical role for CD103 + /CD141 + dendritic cells bearing CCR7 for tumor antigen trafficking and priming of T cell immunity in melanoma. Cancer Cell, 30(2), pp. 324-336. (doi: 10.1016/j.ccell.2016.06.003) (PMID:27424807) (PMCID:PMC5374862)

Headley, Mark B., Bins, Adriaan, Nip, Alyssa, Roberts, Edward W. ORCID: https://orcid.org/0000-0002-8229-1715, Looney, Mark R., Gerard, Audrey and Krummel, Matthew F. (2016) Visualization of immediate immune responses to pioneer metastatic cells in the lung. Nature, 531(7595), pp. 513-517. (doi: 10.1038/nature16985) (PMID:26982733) (PMCID:PMC4892380)

Denton, A.E., Roberts, E.W. ORCID: https://orcid.org/0000-0002-8229-1715, Linterman, M.A. and Fearon, D.T. (2014) Fibroblastic reticular cells of the lymph node are required for retention of resting but not activated CD8+ T cells. Proceedings of the National Academy of Sciences of the United States of America, 111(33), pp. 12139-12144. (doi: 10.1073/pnas.1412910111) (PMID:25092322) (PMCID:PMC4143042)

Feig, C. et al. (2013) Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer. Proceedings of the National Academy of Sciences of the United States of America, 110(50), pp. 20212-20217. (doi: 10.1073/pnas.1320318110) (PMID:24277834) (PMCID:PMC3864274)

Roberts, E. W. et al. (2013) Depletion of stromal cells expressing fibroblast activation protein-α from skeletal muscle and bone marrow results in cachexia and anemia. Journal of Experimental Medicine, 210(6), pp. 1137-1151. (doi: 10.1084/jem.20122344) (PMID:23712428) (PMCID:PMC3674708)

Book Sections

Denton, Alice E., Roberts, Edward W. ORCID: https://orcid.org/0000-0002-8229-1715 and Fearon, Douglas T. (2018) Stromal cells in the tumor microenvironment. In: Owens, Benjamin M.J. and Lakins, Matthew A. (eds.) Stromal Immunology. Series: Advances in Experimental Medicine and Biology, 1060. Springer, pp. 99-114. ISBN 9783319781259 (doi: 10.1007/978-3-319-78127-3_6)

Roberts, E.W. ORCID: https://orcid.org/0000-0002-8229-1715, Denton, A.E. and Fearon, D.T. (2016) Roles of stromal cells in the immune system. In: Bradshaw, Ralph A. and Stahl, Philip D. (eds.) Encyclopedia of Cell Biology. Elsevier, pp. 616-623. ISBN 9780123947963 (doi: 10.1016/B978-0-12-394447-4.30079-7)