Dr David Vetrie

  • Senior Lecturer (Epigenetics)

telephone: 0141 330 7258
email: David.Vetrie@glasgow.ac.uk

Research interests

Gene Regulation in Normal Haematopoietic Development and Disease

My research addresses fundamental questions about the regulatory processes that control the expression of genes during normal haematopoietic development in both human and mouse.  We use state-of-the-art approaches to study these processes both genome-wide and at specific gene loci. Similar approaches are also being implemented to understand the changes in transcriptional and regulatory programmes that occur during the development and treatment of leukaemia.

For more information see his Research pages as follows:

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • ISSF Catalyst: Identification & validation of downstream targets of the histone demethylase KDM4A(JMJD2A) in Acute Myeloid Leukaemia (AML)
    Wellcome Trust
    2015 - 2016
     
  • Targeting p53, cMyc and PRC2 regulatory hubs: A systematic and stratified approach to deliver new therapeutics for CML
    Leukaemia & Lymphoma Research
    2015 - 2020
     
  • Modulation of H3K27 methylation to eradicate TKI-persistant CML stem cells
    Leukaemia & Lymphoma Research
    2014 - 2017
     
  • CiC: Targeting neurotransmitter pathways: identifying novel therapeutics to eradicate CML stem cells
    Medical Research Council
    2014 - 2015
     
  • The role of H2B ubiquitination in genome organisation.
    Biotechnology and Biological Sciences Research Council
    2012 - 2016
     
  • BirA for ChIP -Optimisation of a non-antibody based technology to improve the efficiency of genome-wide analysis of DNA binding sites.
    European Commission
    2008 - 2010
     
  • The Histone code of human haematopoietic stem cell development
    Wellcome Trust
    2008 - 2011
     
  • High Throughput Epigenetic Regulatory Organisation in Chromatin [HEROIC] Transfer
    European Commission
    2007 - 2010
     

Publications

List by: Type | Date

Jump to: 2017 | 2016 | 2015 | 2013 | 2012 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003
Number of items: 29.

2017

Koschmieder, S. and Vetrie, D. (2017) Epigenetic dysregulation in chronic myeloid leukaemia: A myriad of mechanisms and therapeutic options. Seminars in Cancer Biology, (doi:10.1016/j.semcancer.2017.07.006) (PMID:28778403) (In Press)

Holyoake, T. L. and Vetrie, D. (2017) The chronic myeloid leukemia stem cell: stemming the tide of persistence. Blood, 129(12), pp. 1595-1606. (doi:10.1182/blood-2016-09-696013) (PMID:28159740)

Tarafdar, A. et al. (2017) CML cells actively evade host immune surveillance through cytokine-mediated downregulation of MHC-II expression. Blood, 129(2), pp. 199-208. (doi:10.1182/blood-2016-09-742049) (PMID:27793879)

2016

Scott, M. T. et al. (2016) Epigenetic reprogramming sensitizes CML stem cells to combined EZH2 and tyrosine kinase inhibition. Cancer Discovery, 6(11), pp. 1248-1257. (doi:10.1158/2159-8290.CD-16-0263) (PMID:27630125)

Abraham, S. A. et al. (2016) Dual targeting of P53 and C-MYC induces selective elimination of leukemic stem cells. Nature, 534(7607), pp. 341-346. (doi:10.1038/nature18288) (PMID:27281222) (PMCID:PMC4913876)

2015

Holyoake, T. and Vetrie, D. (2015) Cancer: repositioned to kill stem cells. Nature, 525(7569), pp. 328-329. (doi:10.1038/nature15213) (PMID:26331538)

2013

Zhou, Y., Kurukuti, S., Saffrey, P., Vukovic, M., Michie, A.M. , Strogantsev, R., West, A.G. and Vetrie, D. (2013) Chromatin looping defines expression of TAL1, its flanking genes, and regulation in T-ALL. Blood, 122(26), pp. 4199-4209. (doi:10.1182/blood-2013-02-483875)

2012

Vetrie, D. et al. (2012) The gene involved in X-linked agammaglobulinaemia is a member of the Src family of protein-tyrosine kinases. 1993. Journal of Immunology, 188, pp. 2948-2955.

2010

Dhami, P. et al. (2010) Genomic approaches uncover increasing complexities in the regulatory landscape at the human SCL (TAL1) locus. PLoS ONE, 5(2), e9059. (doi:10.1371/journal.pone.0009059)

Dhami, P. et al. (2010) Complex exon-intron marking by histone modifications is not determined solely by nucleosome distribution. PLoS ONE, 5(8), e12339. (doi:10.1371/journal.pone.0012339)

2009

Bruce, A.W. et al. (2009) Functional diversity for REST (NRSF) is defined by in vivo binding affinity hierarchies at the DNA sequence level. Genome Research, 19(6), pp. 994-1006. (doi:10.1101/gr.089086.108)

2008

Balikova, I. et al. (2008) Autosomal-dominant microtia linked to five tandem copies of a copy-number-variable region at chromosome 4p16. American Journal of Human Genetics, 82(1), pp. 181-187. (doi:10.1016/j.ajhg.2007.08.001)

2007

Rodriguez, A. et al. (2007) Requirement of bic/microRNA-155 for normal immune function. Science, 316(5824), pp. 608-611. (doi:10.1126/science.1139253) (PMID:17463290) (PMCID:PMC2610435)

Andrews, R. et al. (2007) The landscape of histone modifications across 1% of the human genome in five human cell lines. Genome Research, 17(6), pp. 691-707.

Birney, E. et al. (2007) Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature, 447(7146), pp. 799-816. (doi:10.1038/nature05874) (PMCID:PMC2212820)

2006

Bolund, L. et al. (2006) Identification of novel deletion breakpoints bordered by segmental duplications in the NF1 locus using high resolution array-CGH. Journal of Medical Genetics, 43(1), pp. 28-38.

Bruce, A. et al. (2006) Identifying gene regulatory elements by genomic microarray mapping of DNaseI hypersensitive sites. Genome Research, 16, pp. 1310-1319. (doi:10.1101/gr.5373606)

2005

Abbs, S., Andrews, R., Coffey, A., Dhami, P., Dumanski, J., Langford, C., Vermeesch, J., Vetrie, D. and Woodward, K. (2005) Exon array CGH: Detection of copy-number changes at the resolution of individual exons in the human genome. American Journal of Human Genetics, 76, pp. 750-762.

Ameur, A. et al. (2005) Binding sites for metabolic disease related transcription factors inferred at base pair resolution by chromatin immunoprecipitation and genomic microarrays. Human Molecular Genetics, 14(22), pp. 3435-3447.

Bolund, L. et al. (2005) Identification of genetic aberrations on chromosome 22 outside the NF2 locus in schwannomatosis and neurofibromatosis type 2. Human Mutation, 26(6), pp. 540-549.

2004

Almeida, R. et al. (2004) Expression profiling of the Leishmania life cycle: cDNA arrays identify developmentally regulated genes present but not annotated in the genome. Molecular and Biochemical Parasitology, 136, pp. 87-100. (doi:10.1016/j.molbiopara.2004.03.004)

Boultwood, J. et al. (2004) Gene expression profiling in the myelodysplastic syndromes using cDNA microarray technology. British Journal of Haematology, 125(5), pp. 576-583.

Breuning, M., Catsman-Berrevoets, C., Endris, V., Muncke, N., Rappold, G., Ross, M., Sistermans, E., Vetrie, D. and Wogatzky, B. (2004) Position effect on PLP1 may cause a subset of Pelizaeus-Merzbacher disease symptoms. Journal of Medical Genetics, 41(12),

Carter, N. and Vetrie, D. (2004) Applications of genomic microarrays to explore human chromosome structure and function. Human Molecular Genetics, 13, R297-R302.

2003

Bahler, J., Burns, G., Chen, D.R., Langford, C., Lyne, R., Mata, J., Penkett, C.J., Rustici, G. and Vetrie, D. (2003) Whole-genome microarrays of fission yeast: characteristics, accuracy, reproducibility, and processing of array data. BMC Genomics, 4,

Boultwood, J., Eagleton, H., Gama, S., Langford, C., Pellagatti, A., Vetrie, D. and Wainscoat, J. (2003) Gene expression profiling in polycythemia vera using cDNA microarray technology. Cancer Research, 63(14), pp. 3940-3944.

Burford, D., Carr, P., Carter, N., Douglas, E., Fiegler, H., Gorman, P., Hunt, S., Smith, J., Tomlinson, I. and Vetrie, D. (2003) DNA microarrays for comparative genomic hybridization based on DOP-PCR amplification of BAC and PAC clones. (vol 36, pg 361, 2003). Genes Chromosomes and Cancer, 37(2), p. 223.

Burford, D., Carr, P., Carter, N., Douglas, E., Fiegler, H., Gorman, P., Hunt, S., Smith, J., Tomlinson, I. and Vetrie, D. (2003) DNA microarrays for comparative genomic hybridization based on DOP-PCR amplification of BAC and PAC clones. Genes Chromosomes and Cancer, 36(4), pp. 361-374.

Vetrie, D. , Vorechovsky, I. and Zhou, J. (2003) Molecular diagnosis of X-linked agammaglobulinaemia (vol 341, pg 1153, 1993). Lancet, 361(9366), p. 1394.

This list was generated on Sun Nov 19 21:32:30 2017 GMT.
Jump to: Articles
Number of items: 29.

Articles

Koschmieder, S. and Vetrie, D. (2017) Epigenetic dysregulation in chronic myeloid leukaemia: A myriad of mechanisms and therapeutic options. Seminars in Cancer Biology, (doi:10.1016/j.semcancer.2017.07.006) (PMID:28778403) (In Press)

Holyoake, T. L. and Vetrie, D. (2017) The chronic myeloid leukemia stem cell: stemming the tide of persistence. Blood, 129(12), pp. 1595-1606. (doi:10.1182/blood-2016-09-696013) (PMID:28159740)

Tarafdar, A. et al. (2017) CML cells actively evade host immune surveillance through cytokine-mediated downregulation of MHC-II expression. Blood, 129(2), pp. 199-208. (doi:10.1182/blood-2016-09-742049) (PMID:27793879)

Scott, M. T. et al. (2016) Epigenetic reprogramming sensitizes CML stem cells to combined EZH2 and tyrosine kinase inhibition. Cancer Discovery, 6(11), pp. 1248-1257. (doi:10.1158/2159-8290.CD-16-0263) (PMID:27630125)

Abraham, S. A. et al. (2016) Dual targeting of P53 and C-MYC induces selective elimination of leukemic stem cells. Nature, 534(7607), pp. 341-346. (doi:10.1038/nature18288) (PMID:27281222) (PMCID:PMC4913876)

Holyoake, T. and Vetrie, D. (2015) Cancer: repositioned to kill stem cells. Nature, 525(7569), pp. 328-329. (doi:10.1038/nature15213) (PMID:26331538)

Zhou, Y., Kurukuti, S., Saffrey, P., Vukovic, M., Michie, A.M. , Strogantsev, R., West, A.G. and Vetrie, D. (2013) Chromatin looping defines expression of TAL1, its flanking genes, and regulation in T-ALL. Blood, 122(26), pp. 4199-4209. (doi:10.1182/blood-2013-02-483875)

Vetrie, D. et al. (2012) The gene involved in X-linked agammaglobulinaemia is a member of the Src family of protein-tyrosine kinases. 1993. Journal of Immunology, 188, pp. 2948-2955.

Dhami, P. et al. (2010) Genomic approaches uncover increasing complexities in the regulatory landscape at the human SCL (TAL1) locus. PLoS ONE, 5(2), e9059. (doi:10.1371/journal.pone.0009059)

Dhami, P. et al. (2010) Complex exon-intron marking by histone modifications is not determined solely by nucleosome distribution. PLoS ONE, 5(8), e12339. (doi:10.1371/journal.pone.0012339)

Bruce, A.W. et al. (2009) Functional diversity for REST (NRSF) is defined by in vivo binding affinity hierarchies at the DNA sequence level. Genome Research, 19(6), pp. 994-1006. (doi:10.1101/gr.089086.108)

Balikova, I. et al. (2008) Autosomal-dominant microtia linked to five tandem copies of a copy-number-variable region at chromosome 4p16. American Journal of Human Genetics, 82(1), pp. 181-187. (doi:10.1016/j.ajhg.2007.08.001)

Rodriguez, A. et al. (2007) Requirement of bic/microRNA-155 for normal immune function. Science, 316(5824), pp. 608-611. (doi:10.1126/science.1139253) (PMID:17463290) (PMCID:PMC2610435)

Andrews, R. et al. (2007) The landscape of histone modifications across 1% of the human genome in five human cell lines. Genome Research, 17(6), pp. 691-707.

Birney, E. et al. (2007) Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature, 447(7146), pp. 799-816. (doi:10.1038/nature05874) (PMCID:PMC2212820)

Bolund, L. et al. (2006) Identification of novel deletion breakpoints bordered by segmental duplications in the NF1 locus using high resolution array-CGH. Journal of Medical Genetics, 43(1), pp. 28-38.

Bruce, A. et al. (2006) Identifying gene regulatory elements by genomic microarray mapping of DNaseI hypersensitive sites. Genome Research, 16, pp. 1310-1319. (doi:10.1101/gr.5373606)

Abbs, S., Andrews, R., Coffey, A., Dhami, P., Dumanski, J., Langford, C., Vermeesch, J., Vetrie, D. and Woodward, K. (2005) Exon array CGH: Detection of copy-number changes at the resolution of individual exons in the human genome. American Journal of Human Genetics, 76, pp. 750-762.

Ameur, A. et al. (2005) Binding sites for metabolic disease related transcription factors inferred at base pair resolution by chromatin immunoprecipitation and genomic microarrays. Human Molecular Genetics, 14(22), pp. 3435-3447.

Bolund, L. et al. (2005) Identification of genetic aberrations on chromosome 22 outside the NF2 locus in schwannomatosis and neurofibromatosis type 2. Human Mutation, 26(6), pp. 540-549.

Almeida, R. et al. (2004) Expression profiling of the Leishmania life cycle: cDNA arrays identify developmentally regulated genes present but not annotated in the genome. Molecular and Biochemical Parasitology, 136, pp. 87-100. (doi:10.1016/j.molbiopara.2004.03.004)

Boultwood, J. et al. (2004) Gene expression profiling in the myelodysplastic syndromes using cDNA microarray technology. British Journal of Haematology, 125(5), pp. 576-583.

Breuning, M., Catsman-Berrevoets, C., Endris, V., Muncke, N., Rappold, G., Ross, M., Sistermans, E., Vetrie, D. and Wogatzky, B. (2004) Position effect on PLP1 may cause a subset of Pelizaeus-Merzbacher disease symptoms. Journal of Medical Genetics, 41(12),

Carter, N. and Vetrie, D. (2004) Applications of genomic microarrays to explore human chromosome structure and function. Human Molecular Genetics, 13, R297-R302.

Bahler, J., Burns, G., Chen, D.R., Langford, C., Lyne, R., Mata, J., Penkett, C.J., Rustici, G. and Vetrie, D. (2003) Whole-genome microarrays of fission yeast: characteristics, accuracy, reproducibility, and processing of array data. BMC Genomics, 4,

Boultwood, J., Eagleton, H., Gama, S., Langford, C., Pellagatti, A., Vetrie, D. and Wainscoat, J. (2003) Gene expression profiling in polycythemia vera using cDNA microarray technology. Cancer Research, 63(14), pp. 3940-3944.

Burford, D., Carr, P., Carter, N., Douglas, E., Fiegler, H., Gorman, P., Hunt, S., Smith, J., Tomlinson, I. and Vetrie, D. (2003) DNA microarrays for comparative genomic hybridization based on DOP-PCR amplification of BAC and PAC clones. (vol 36, pg 361, 2003). Genes Chromosomes and Cancer, 37(2), p. 223.

Burford, D., Carr, P., Carter, N., Douglas, E., Fiegler, H., Gorman, P., Hunt, S., Smith, J., Tomlinson, I. and Vetrie, D. (2003) DNA microarrays for comparative genomic hybridization based on DOP-PCR amplification of BAC and PAC clones. Genes Chromosomes and Cancer, 36(4), pp. 361-374.

Vetrie, D. , Vorechovsky, I. and Zhou, J. (2003) Molecular diagnosis of X-linked agammaglobulinaemia (vol 341, pg 1153, 1993). Lancet, 361(9366), p. 1394.

This list was generated on Sun Nov 19 21:32:30 2017 GMT.