2024

Pennel, K., Dutton, L. , Melissourgou-Syka, L. , Roxburgh, C. , Birch, J. and Edwards, J. (2024) Novel radiation and targeted therapy combinations for improving rectal cancer outcomes. Expert Reviews in Molecular Medicine, (doi: 10.1017/erm.2024.15) (PMID:38623751) (Accepted for Publication)

Ingham,, A. R. et al. (2024) Robotic-assisted surgery for left sided colon and rectal resections is associated with reduction in the postoperative surgical stress response and improved short-term outcomes: a cohort study. Surgical Endoscopy, (doi: 10.1007/s00464-024-10749-3) (PMID:38498212)

Pennel, K. A.F. et al. (2024) JAK/STAT3 represents a therapeutic target for colorectal cancer patients with stromal-rich tumors. Journal of Experimental and Clinical Cancer Research, 43, 64. (doi: 10.1186/s13046-024-02958-4)

Hillson, L. V. S., McCulloch, A. K., Edwards, J. , Dunne, P. D., O'Cathail, S. M. and Roxburgh, C. S. (2024) Radiation-induced changes in gene expression in rectal cancer specimens. Clinical and Translational Oncology, (doi: 10.1007/s12094-023-03361-9) (PMID:38243085) (Early Online Publication)

2023

Galbraith, N. J. et al. (2023) Effect of differing flap reconstruction strategies in perineal closure following advanced pelvic oncological resection: a retrospective cohort study. International Journal of Surgery, 109(11), pp. 3375-3382. (doi: 10.1097/JS9.0000000000000617) (PMID:37678294) (PMCID:PMC10651229)

Bradley, N.A., Walter, A., Wilson, A., Siddiqui, T., Roxburgh, C.S.D. , McMillan, D.C. and Guthrie, G.J.K. (2023) The relationship between CT-derived body composition, systemic inflammation, and survival in patients with abdominal aortic aneurysm. Journal of Vascular Surgery, 78(4), 937-944.e4. (doi: 10.1016/j.jvs.2023.06.012) (PMID:37385355)

McMahon, R. K., O'Cathail, S. M. , Nair, H., Steele, C. W. , Platt, J. J., Digby, M., McDonald, A. C., Horgan, P. G. and Roxburgh, C. S.D. (2023) The neoadjuvant rectal score and a novel magnetic resonance imaging based neoadjuvant rectal score are stage independent predictors of long-term outcome in locally advanced rectal cancer. Colorectal Disease, 25(9), pp. 1783-1794. (doi: 10.1111/codi.16667) (PMID:37485654)

Beach, C. et al. (2023) Innate immune receptor C5aR1 regulates cancer cell fate and can be targeted to improve radiotherapy in tumours with immunosuppressive microenvironments. Journal of Clinical Investigation, (Accepted for Publication)

Bradley, N.A., Walter, A., Wilson, A., Siddiqui, T., Roxburgh, C.S.D. , McMillan, D.C. and Guthrie, G.J.K. (2023) The prognostic value of pre-operative systemic inflammation-based scoring in patients undergoing endovascular repair of AAA. Journal of Vascular Surgery, 78(2), 362-369.e2. (doi: 10.1016/j.jvs.2023.04.018) (PMID:37086821)

Bradley, N. A., Walter, A., Dolan, R. , Wilson, A., Siddiqui, T., Roxburgh, C. S.D. , McMillan, D. C. and Guthrie, G. J.K. (2023) Evaluation of the prognostic value of computed tomography-derived body composition in patients undergoing endovascular aneurysm repair. Journal of Cachexia, Sarcopenia and Muscle, 14(4), pp. 1836-1847. (doi: 10.1002/jcsm.13262) (PMID:37221439) (PMCID:PMC10401537)

Bradley, N.A., Walter, A., Roxburgh, C.S.D. , McMillan, D.C. and Guthrie, G.J.K. (2023) The relationship between clinical frailty score, CT-derived body composition, systemic inflammation, and survival in patients with chronic limb threatening ischaemia. Annals of Vascular Surgery, (doi: 10.1016/j.avsg.2023.06.012) (PMID:37356659) (In Press)

Day, E. K., Galbraith, N. J. , Ward, H. J.T. and Roxburgh, C. S. (2023) Volume-outcome relationship in intra-abdominal robotic-assisted surgery: a systematic review. Journal of Robotic Surgery, 17(3), pp. 811-826. (doi: 10.1007/s11701-022-01461-2) (PMID:36315379)

Wood, C. S. et al. (2023) Spatially resolved transcriptomics deconvolutes prognostic histological subgroups in patients with colorectal cancer and synchronous liver metastases. Cancer Research, 83(8), pp. 1329-1344. (doi: 10.1158/0008-5472.CAN-22-2794) (PMID:37057593) (PMCID:PMC10102851)

Alexander, P.G., van Wyk, H.C. , Pennel, K.A.F., Hay, J., McMillan, D.C. , Horgan, P.G. , Roxburgh, C.S.D. , Edwards, J. and Park, J.H. (2023) The Glasgow Microenvironment Score and risk and site of recurrence in TNM I–III colorectal cancer. British Journal of Cancer, 128(4), pp. 556-567. (doi: 10.1038/s41416-022-02069-x) (PMID:36476660) (PMCID:PMC9938140)

2022

Golder, A. M. , Sin, L. K. E., Alani, F., Dolan, R. , Mansouri, D. , Horgan, P. G. , McMillan, D. C. and Roxburgh, C. S. (2022) The relationship between the mode of presentation, CT-derived body composition, systemic inflammatory grade and survival in colon cancer. Journal of Cachexia, Sarcopenia and Muscle, 13(6), pp. 2863-2874. (doi: 10.1002/jcsm.13097) (PMID:36218135) (PMCID:PMC9745485)

Pennel, K. A. F. et al. (2022) CXCL8 expression is associated with advanced stage, right sidedness, and distinct histological features of colorectal cancer. Journal of Pathology: Clinical Research, 8(6), pp. 509-520. (doi: 10.1002/cjp2.290) (PMID:35879507) (PMCID:PMC9535100)

Bradley, N.A., Roxburgh, C.S.D. , McMillan, D.C. and Guthrie, G.J.K. (2022) The relationship between pre-operative psoas and skeletal muscle parameters and survival following endovascular aneurysm repair: a systematic review and meta-analysis. Scientific Reports, 12, 16663. (doi: 10.1038/s41598-022-20490-3) (PMID:36198699) (PMCID:PMC9534993)

Golder, A.M. , Mshihadani, A., McMillan, D.C. , Horgan, P.G. , Roxburgh, C.S. and Mansouri, D. (2022) Route to diagnosis of colorectal cancer and association with survival within the context of a bowel screening programme. Public Health, 211, pp. 53-61. (doi: 10.1016/j.puhe.2022.06.032) (PMID:36027788)

Metcalfe, K. H.M., Knight, K., McIntosh, S., Hunter, R., MacKay, C., McCabe, G., Sahni, D., Ramsay, G., Roxburgh, C. and Richards, C. (2022) Disease recurrence after right hemicolectomy in Scotland: Is there rationale to adopt complete mesocolic excision (CME)? Surgeon, 20(5), pp. 301-308. (doi: 10.1016/j.surge.2021.09.009) (PMID:34794905)

Alexander, P. G. et al. (2022) The relationship between the Glasgow Microenvironment Score and markers of epithelial-mesenchymal transition in TNM II-III colorectal cancer. Human Pathology, 127, pp. 1-11. (doi: 10.1016/j.humpath.2022.05.012) (PMID:35623467)

Cheong, C. M., Golder, A. , Horgan, P. , Roxburgh, C. and McMillan, D. (2022) Relationship between pre‑operative glycated haemoglobin and surgical site infection in patients undergoing elective colon cancer surgery. Oncology Letters, 24(3), 296. (doi: 10.3892/ol.2022.13416) (PMID:35949622) (PMCID:PMC9353220)

Gould, L. E., Pring, E. T., Drami, I., Moorghen, M., Naghibi, M., Jenkins, J. T., Steele, C. W. and Roxburgh, C. S.D. (2022) A systematic review of the pathological determinants of outcome following resection by pelvic exenteration of locally advanced and locally recurrent rectal cancer. International Journal of Surgery, 104, 106738. (doi: 10.1016/j.ijsu.2022.106738) (PMID:35781038)

McGovern, J., Golder, A. M. , Dolan, R. D. , Roxburgh, C. S.D. , Horgan, P. G. and McMillan, D. C. (2022) The combination of computed tomography-derived muscle mass and muscle density and relationship with clinicopathological characteristics and survival in patients undergoing potentially curative surgery for colorectal cancer. JCSM Clinical Reports, 7(3), pp. 65-76. (doi: 10.1002/crt2.54)

Ross, F. A., Park, J. H. , Mansouri, D. , Combet, E. , Horgan, P. G. , McMillan, D. C. and Roxburgh, C. S.D. (2022) The role of faecal calprotectin in diagnosis and staging of colorectal neoplasia: a systematic review and meta-analysis. BMC Gastroenterology, 22, 176. (doi: 10.1186/s12876-022-02220-1) (PMID:35397505) (PMCID:PMC8994317)

Golder, A. M. , McMillan, D. C. , Horgan, P. G. and Roxburgh, C. S.D. (2022) Determinants of emergency presentation in patients with colorectal cancer: a systematic review and meta-analysis. Scientific Reports, 12, 4366. (doi: 10.1038/s41598-022-08447-y) (PMID:35288664) (PMCID:PMC8921241)

Ross, F. A., Park, J. H. , Mansouri, D. , Little, C., Di Rollo, D. G., Combet, E. , Van Wyk, H. , Horgan, P. G. , McMillan, D. C. and Roxburgh, C. S. D. (2022) The role of faecal calprotectin in the identification of colorectal neoplasia in patients attending for screening colonoscopy. Colorectal Disease, 24(2), pp. 188-196. (doi: 10.1111/codi.15942) (PMID:34614299)

Zaborowski, A. M. et al. (2022) Microsatellite instability in young patients with rectal cancer: molecular findings and treatment response. British Journal of Surgery, 109(3), pp. 251-255. (doi: 10.1093/bjs/znab437) (PMID:35030243)

Cheong, C. M., Golder, A. M. , Horgan, P. D. , McMillan, D. C. and Roxburgh, C. S.D. (2022) Evaluation of clinical prognostic variables on short-term outcome for colorectal cancer surgery: an overview and minimum dataset. Cancer Treatment and Research Communications, 31, 100544. (doi: 10.1016/j.ctarc.2022.100544) (PMID:35248885)

2021

Hernon, J. et al. (2021) SupPoRtive Exercise Programmes for Accelerating REcovery after major ABdominal Cancer surgery trial (PREPARE-ABC): pilot phase of a multicentre randomised controlled trial. Colorectal Disease, 23(11), pp. 3008-3022. (doi: 10.1111/codi.15856) (PMID:34355484)

Knight, K. A., Drami, I., McMillan, D. C. , Horgan, P. G. , Park, J. H. , Jenkins, J. T. and Roxburgh, C. S.D. (2021) Vascular calcification and response to neoadjuvant therapy in locally advanced rectal cancer: an exploratory study. Journal of Cancer Research and Clinical Oncology, 147(11), pp. 3409-3420. (doi: 10.1007/s00432-021-03570-1) (PMID:33710416) (PMCID:PMC8484095)

Zaborowski, A. M. et al. (2021) Characteristics of early-onset vs late-onset colorectal cancer. JAMA Surgery, 156(9), pp. 865-874. (doi: 10.1001/jamasurg.2021.2380) (PMID:34190968)

Hanna, C. R. et al. (2021) Durvalumab (MEDI 4736) in combination with extended neoadjuvant regimens in rectal cancer: a study protocol of a randomised phase II trial (PRIME-RT). Radiation Oncology, 16, 163. (doi: 10.1186/s13014-021-01888-1) (PMID:34446053)

Knight, K. A., Hon Fei, C., Boland, K. F., Dolan, D. R., Golder, A. M. , McMillan, D. C. , Horgan, P. G. , Black, D. H., Park, J. H. and Roxburgh, C. S.D. (2021) Aortic calcification is associated with non-infective rather than infective postoperative complications following colorectal cancer resection: an observational cohort study. European Radiology, 31(6), pp. 4319-4329. (doi: 10.1007/s00330-020-07189-7) (PMID:33201280)

Al-Badran, S. S.F. et al. (2021) Relationship between immune checkpoint proteins, tumour microenvironment characteristics, and prognosis in primary operable colorectal cancer. Journal of Pathology: Clinical Research, 7(2), pp. 121-134. (doi: 10.1002/cjp2.193) (PMID:33338327)

Alexander, P.G. et al. (2021) The Glasgow Microenvironment Score associates with prognosis and adjuvant chemotherapy response in colorectal cancer. British Journal of Cancer, 124, pp. 786-796. (doi: 10.1038/s41416-020-01168-x) (PMID:33223535)

Knight, K., Al-Wahid, M., Choong, J. X., Burton, K., Lindsay, R., McKee, R. F., Anderson, J. H. and Roxburgh, C. S.D. (2021) Multidisciplinary management of anal intraepithelial neoplasia and rate of progression to cancer: a retrospective cohort study. European Journal of Surgical Oncology, 47(2), pp. 304-310. (doi: 10.1016/j.ejso.2020.08.011) (PMID:32873453)

Alhayyan, A. M. , McSorley, S. T. , Kearns, R. J. , Horgan, P. G. , Roxburgh, C. S.D. and McMillan, D. C. (2021) The effect of anesthesia on the magnitude of the postoperative systemic inflammatory response in patients undergoing elective surgery for colorectal cancer in the context of an enhanced recovery pathway: A prospective cohort study. Medicine, 100(2), e23997. (doi: 10.1097/MD.0000000000023997) (PMID:33466141) (PMCID:PMC7808526)

Knight, K., Choong, J.X., McKee, R.F., Anderson, J.H., Horgan, P.G. , McMillan, D.C. , McDonald, A. and Roxburgh, C.S. (2021) The influence of systemic inflammation on treatment response and survival in anal squamous cell cancer. Clinical Oncology, 33(1), e22-e30. (doi: 10.1016/j.clon.2020.06.010) (PMID:32709540)

Hanna, C. R. , O'Cathail, S. M. , Graham, J., Adams, R. and Roxburgh, C. S.D. (2021) Immune checkpoint inhibition as a strategy in the neoadjuvant treatment of locally advanced rectal cancer. Journal of Immunotherapy and Precision Oncology, 4(2), (doi: 10.36401/JIPO-20-31)

2020

Dolan, R. D. , Alwahid, M., McSorley, S. T. , Park, J. H. , Stevenson, R. P., Roxburgh, C. S. , Horgan, P. G. and McMillan, D. C. (2020) A comparison of the prognostic value of composite ratios and cumulative scores in patients with operable rectal cancer. Scientific Reports, 10, 17965. (doi: 10.1038/s41598-020-73909-0) (PMID:33087753) (PMCID:PMC7578034)

Roseweir, A. K. et al. (2020) Histological phenotypic subtypes predict recurrence risk and response to adjuvant chemotherapy in patients with stage III colorectal cancer. Journal of Pathology: Clinical Research, 6(4), pp. 283-296. (doi: 10.1002/cjp2.171) (PMID:32401426) (PMCID:PMC7578335)

Golder, A.M. , Steele, C.W. , Conn, D., Mackay, G.J., McMillan, D.C. , Horgan, P.G. , Roxburgh, C.S. and McSorley, S.T. (2020) Authors' reply: Effect of preoperative oral antibiotics in combination with mechanical bowel preparation on inflammatory response and short-term outcomes following left-sided colonic and rectal resections. BJS Open, 4(4), pp. 730-731. (doi: 10.1002/bjs5.50286) (PMID:32297454) (PMCID:PMC7397349)

Park, J. H. , Fuglestad, A. J., Køstner, A. H., Oliwa, A., Graham, J., Horgan, P. G. , Roxburgh, C. S.D. , Kersten, C. and McMillan, D. C. (2020) Systemic inflammation and outcome in 2295 patients with stage I-III colorectal cancer from Scotland and Norway: First results from the ScotScan Colorectal Cancer Group. Annals of Surgical Oncology, 27, pp. 2784-2794. (doi: 10.1245/s10434-020-08268-1) (PMID:32248375) (PMCID:PMC7334267)

Cercek, A. et al. (2020) Mismatch repair-deficient rectal cancer and resistance to neoadjuvant chemotherapy. Clinical Cancer Research, 26(13), pp. 3271-3279. (doi: 10.1158/1078-0432.CCR-19-3728) (PMID:32144135) (PMCID:PMC7348681)

McSorley, S. T. , Anderson, J. H., Whittle, T., Roxburgh, C. S. , Horgan, P. G. , McMillan, D. C. and Steele, C. W. (2020) The impact of preoperative systemic inflammation on the efficacy of intravenous iron infusion to correct anaemia prior to surgery for colorectal cancer. Perioperative Medicine, 9, 17. (doi: 10.1186/s13741-020-00146-4) (PMID:32537137) (PMCID:PMC7288411)

ALHAYYAN, A. , McSorley, S. T. , Kearns, R. J. , Horgan, P. G. , Roxburgh, C. S.D. and McMillan, D. C. (2020) The relationship between anaesthetic technique, clinicopathological characteristics and the magnitude of the postoperative systemic inflammatory response in patients undergoing elective surgery for colon cancer. PLoS ONE, 15(4), e0228580. (doi: 10.1371/journal.pone.0228580) (PMID:32348308) (PMCID:PMC7190171)

Alhayyan, A. , McSorley, S. , Roxburgh, C. , Kearns, R. , Horgan, P. and McMillan, D. (2020) The effect of anesthesia on the postoperative systemic inflammatory response in patients undergoing surgery: a systematic review and meta-analysis. Surgery Open Science, 2(1), pp. 1-21. (doi: 10.1016/j.sopen.2019.06.001) (PMID:32754703) (PMCID:PMC7391900)

Chapman, S.J. et al. (2020) Safety and efficacy of non‐steroidal anti‐inflammatory drugs to reduce ileus after colorectal surgery. British Journal of Surgery, 107(2), e161-e169. (doi: 10.1002/bjs.11326) (PMID:31595986)

Knight, K.A., Horgan, P.G. , McMillan, D.C. , Roxburgh, C.S.D. and Park, J.H. (2020) The relationship between aortic calcification and anastomotic leak following gastrointestinal resection: a systematic review. International Journal of Surgery, 73, pp. 42-49. (doi: 10.1016/j.ijsu.2019.11.023) (PMID:31765846)

McSorley, S. T. , Tham, A., Dolan, R. D. , Steele, C. W. , Ramsingh, J., Roxburgh, C. , Horgan, P. G. and McMillan, D. C. (2020) Perioperative blood transfusion is associated with the postoperative systemic inflammatory response and poorer outcomes following surgery for colorectal cancer. Annals of Surgical Oncology, 27, pp. 833-843. (doi: 10.1245/s10434-019-07984-7) (PMID:31664621) (PMCID:PMC7000540)

2019

Golder, A.M. , Steele, C.W. , Conn, D., Mackay, G.J., McMillan, D.C. , Horgan, P.G. , Roxburgh, C.S. and McSorley, S.T. (2019) Effect of preoperative oral antibiotics in combination with mechanical bowel preparation on inflammatory response and short‐term outcomes following left‐sided colonic and rectal resections. BJS Open, 3(6), pp. 830-839. (doi: 10.1002/bjs5.50224) (PMID:31832590) (PMCID:PMC6887908)

Golder, A. M. , McSorley, S. T. , Kearns, R. J. , McMillan, D. C. , Horgan, P. G. and Roxburgh, C. S. (2019) Attitudes towards the use of perioperative steroids in resectional colorectal cancer surgery in the UK: a qualitative study. Annals of Medicine and Surgery, 48, pp. 23-28. (doi: 10.1016/j.amsu.2019.10.007) (PMID:31687135) (PMCID:PMC6820077)

Kroon, H. M. et al. (2019) Palliative pelvic exenteration: A systematic review of patient-centered outcomes. European Journal of Surgical Oncology, 45(10), pp. 1787-1795. (doi: 10.1016/j.ejso.2019.06.011) (PMID:31255441)

Roxburgh, C.S.D. et al. (2019) Changes in the multidisciplinary management of rectal cancer from 2009 to 2015 and associated improvements in short‐term outcomes. Colorectal Disease, 21(10), pp. 1140-1150. (doi: 10.1111/codi.14713) (PMID:31108012) (PMCID:PMC6773478)

Jackstadt, R. et al. (2019) Epithelial NOTCH signaling rewires the tumor microenvironment of colorectal cancer to drive poor-prognosis subtypes and metastasis. Cancer Cell, 36(3), 319-336.e7. (doi: 10.1016/j.ccell.2019.08.003) (PMID:31526760) (PMCID:PMC6853173)

Park, J. H. , van Wyk, H. , McMillan, D. C. , Edwards, J. , Orange, C., Horgan, P. G. and Roxburgh, C. S.D. (2019) Pre-operative, biopsy-based assessment of the tumour microenvironment in patients with primary operable colorectal cancer. Journal of Pathology: Clinical Research, 6(1), pp. 30-39. (doi: 10.1002/cjp2.143) (PMID:31486287) (PMCID:PMC6966701)

McSorley, S. T. , Dolan, R. D. , Roxburgh, C. S.D. , Horgan, P. G. , MacKay, G. J. and McMillan, D. C. (2019) Possible dose dependent effect of perioperative dexamethasone and laparoscopic surgery on the postoperative systemic inflammatory response and complications following surgery for colon cancer. European Journal of Surgical Oncology, 45(9), pp. 1613-1618. (doi: 10.1016/j.ejso.2019.05.020) (PMID:31130339)

McSorley, S. T. , Tham, A., Steele, C. W. , Dolan, R. D. , Roxburgh, C. S.D. , Horgan, P. G. and McMillan, D. C. (2019) Quantitative data on red cell measures of iron status and their relation to the magnitude of the systemic inflammatory response and survival in patients with colorectal cancer. European Journal of Surgical Oncology, 45(7), pp. 1205-1211. (doi: 10.1016/j.ejso.2019.02.027) (PMID:30850153)

Smith, J. J. et al. (2019) Assessment of a watch-and-wait strategy for rectal cancer in patients with a complete response after neoadjuvant therapy. JAMA Oncology, 5(4), e185896. (doi: 10.1001/jamaoncol.2018.5896) (PMID:30629084) (PMCID:PMC6459120)

Roxburgh, C. S.D. et al. (2019) Role of the interval from completion of neoadjuvant therapy to surgery in postoperative morbidity in patients with locally advanced rectal cancer. Annals of Surgical Oncology, 26, pp. 2019-2027. (doi: 10.1245/s10434-019-07340-9) (PMID:30963399) (PMCID:PMC6579536)

McSorley, S. , Johnstone, M., Steele, C. W. , Roxburgh, C. S.D. , Horgan, P. G. , McMillan, D. C. and Mansouri, D. (2019) Normocytic anaemia is associated with systemic inflammation and poorer survival in patients with colorectal cancer treated with curative intent. International Journal of Colorectal Disease, 34(3), pp. 401-408. (doi: 10.1007/s00384-018-3211-7) (PMID:30515556)

Roseweir, A.K. et al. (2019) A novel tumor-based epithelial-to-mesenchymal transition score that associates with prognosis and metastasis in patients with stage II/III colorectal cancer. International Journal of Cancer, 144(1), pp. 150-159. (doi: 10.1002/ijc.31739) (PMID:29992570)

2018

Roxburgh, C. S. and Weiser, M. R. (2018) Selective use of radiation for locally advanced rectal cancer: one size does not fit all. Minerva Chirurgica, 73(6), pp. 592-600. (doi: 10.23736/S0026-4733.18.07791-X) (PMID:29806758)

Roxburgh, C. S. , Fenig, Y. M., Cercek, A., Shia, J., Rassam, R. M., Paty, P. B. and Nash, G. M. (2018) Outcomes of low-grade appendiceal mucinous neoplasms with remote acellular mucinous peritoneal deposits. Annals of Surgical Oncology, 26, pp. 118-124. (doi: 10.1245/s10434-018-7003-7) (PMID:30421044) (PMCID:PMC6339600)

Park, J. H. et al. (2018) Staging the tumor and staging the host: A two centre, two country comparison of systemic inflammatory responses of patients undergoing resection of primary operable colorectal cancer. American Journal of Surgery, 216(3), pp. 458-464. (doi: 10.1016/j.amjsurg.2017.08.044) (PMID:28967380)

Dolan, R. D. , McSorley, S. T. , Park, J. H. , Watt, D. G. , Roxburgh, C. S. , Horgan, P. G. and McMillan, D. C. (2018) The prognostic value of systemic inflammation in patients undergoing surgery for colon cancer: comparison of composite ratios and cumulative scores. British Journal of Cancer, 119(1), pp. 40-51. (doi: 10.1038/s41416-018-0095-9) (PMID:29789606)

McSorley, S. T. , Roxburgh, C. S.D. , Horgan, P. G. and McMillan, D. C. (2018) The relationship between cardiopulmonary exercise test variables, the systemic inflammatory response, and complications following surgery for colorectal cancer. Perioperative Medicine, 7(1), 11. (doi: 10.1186/s13741-018-0093-8) (PMID:29983927) (PMCID:PMC6003031)

Cercek, A. et al. (2018) Adoption of total neoadjuvant therapy for locally advanced rectal cancer. JAMA Oncology, 4(6), e180071. (doi: 10.1001/jamaoncol.2018.0071) (PMID:29566109) (PMCID:PMC5885165)

Patel, M., McSorley, S. T. , Park, J. H. , Roxburgh, C. S.D. , Edwards, J. , Horgan, P. G. and McMillan, D. C. (2018) The relationship between right-sided tumour location, tumour microenvironment, systemic inflammation, adjuvant therapy and survival in patients undergoing surgery for colon and rectal cancer. British Journal of Cancer, 118(5), pp. 705-712. (doi: 10.1038/bjc.2017.441) (PMID:29337962) (PMCID:PMC5846060)

Dolan, R. , McSorley, S. T. , Park, J. H. , Roxburgh, C. S.D. , Horgan, P. G. and McMillan, D. C. (2018) The Prognostic Value of Systemic Inflammation in Patients Undergoing Surgery for Rectal Cancer: Comparison of Composite Ratios and Cumulative Scores. Gastrointestinal Cancers Symposium, San Francisco, CA, USA, 18-20 Jan 2018. (doi: 10.1200/JCO.2018.36.4_suppl.579)

Roxburgh, C. S. , Shia, J., Vakiani, E., Daniel, T. and Weiser, M. R. (2018) Potential immune priming of the tumor microenvironment with FOLFOX chemotherapy in locally advanced rectal cancer. OncoImmunology, 7(6), e1435227. (doi: 10.1080/2162402x.2018.1435227) (PMID:29872576)

2017

Mcsorley, S. T. , Roxburgh, C. S.D. , Horgan, P. G. and McMillan, D. C. (2017) The impact of preoperative dexamethasone on the magnitude of the postoperative systemic inflammatory response and complications following surgery for colorectal cancer. Annals of Surgical Oncology, 24(8), pp. 2104-2112. (doi: 10.1245/s10434-017-5817-3) (PMID:28251379)

Park, J. H. , Roxburgh, C. S.D. , Edwards, J. , Horgan, P. G. and McMillan, D. C. (2017) In reply to "Hynes S.O. et al. Back to the future: routine morphological assessment of the tumour microenvironment is prognostic in stage II/III colon cancer in a large population-based study". Histopathology, 71(2), pp. 326-327. (doi: 10.1111/his.13195) (PMID:28226191)

Park, J.H. , Van Wyk, H. , Roxburgh, C.S.D. , Horgan, P.G. , Edwards, J. and McMillan, D.C. (2017) Tumour invasiveness, the local and systemic environment and the basis of staging systems in colorectal cancer. British Journal of Cancer, 116, pp. 1444-1450. (doi: 10.1038/bjc.2017.108)

McSorley, S. T. , Roxburgh, C. S. , Horgan, P. G. and McMillan, D. C. (2017) Re: Dexamethasone versus standard treatment for postoperative nausea and vomiting in gastrointestinal surgery: randomised controlled trial (DREAMS Trial). British Medical Journal, 357, j1455.

Park, J. H. , Van Wyk, H. C., McMillan, D. C. , Quinn, J. A. , Clark, J., Roxburgh, C. , Horgan, P. G. and Edwards, J. (2017) Signal transduction and activator of transcription-3 (STAT3) in patients with colorectal cancer: associations with the phenotypic features of the tumour and host. Clinical Cancer Research, 23(7), pp. 1698-1709. (doi: 10.1158/1078-0432.CCR-16-1416) (PMID:27678454)

Little, C. H., Combet, E. , McMillan, D. C. , Horgan, P. G. and Roxburgh, C. S.D. (2017) The role of dietary polyphenols in the moderation of the inflammatory response in early stage colorectal cancer. Critical Reviews in Food Science and Nutrition, 57(11), pp. 2310-2320. (doi: 10.1080/10408398.2014.997866)

McSorley, S. T. , Dolan, R. D. , Roxburgh, C. S.D. , McMillan, D. C. and Horgan, P. G. (2017) How and why systemic inflammation worsens quality of life in patients with advanced cancer. Expert Review of Quality of Life in Cancer Care, 2(3), pp. 167-175. (doi: 10.1080/23809000.2017.1331705)

2016

Patel, S. V. et al. (2016) Distance to the anal verge is associated with pathologic complete response to neoadjuvant therapy in locally advanced rectal cancer. Journal of Surgical Oncology, 114(5), pp. 637-641. (doi: 10.1002/jso.24358) (PMID:27641934) (PMCID:PMC5516624)

Park, J. H. , McMillan, D. C. , Edwards, J. , Horgan, P. G. and Roxburgh, C. S.D. (2016) Comparison of the prognostic value of measures of the tumor inflammatory cell infiltrate and tumor-associated stroma in patients with primary operable colorectal cancer. OncoImmunology, 5(3), e1098801. (doi: 10.1080/2162402X.2015.1098801)

Park, J. H. , Watt, D. G., Roxburgh, C. S.D. , Horgan, P. G. and McMillan, D. C. (2016) Colorectal cancer, systemic inflammation, and outcome: staging the tumor and staging the host. Annals of Surgery, 263(2), pp. 326-336. (doi: 10.1097/SLA.0000000000001122) (PMID:25575264)

Roxburgh, C. and McMillan, D. (2016) Therapeutics targeting innate immune/inflammatory responses through the interleukin-6/JAK/STAT signal transduction pathway in patients with cancer. Translational Research, 167(1), pp. 61-66. (doi: 10.1016/j.trsl.2015.08.013) (PMID:26432924)

Park, J. H. , Powell, A. G., Roxburgh, C. S.D. , Horgan, P. G. , McMillan, D. c. and Edwards, J. (2016) Mismatch repair status in patients with primary operable colorectal cancer: associations with the local and systemic tumour environment. British Journal of Cancer, 114, pp. 562-570. (doi: 10.1038/bjc.2016.17) (PMID:26859693)

2015

VAN Wyk, H. C., Foulis, A., Roxburgh, C. , Orange, C., Horgan, P. and McMillan, D. (2015) Comparison of methods to identify lymphatic and blood vessel invasion and their prognostic value in patients with primary operable colorectal cancer. Anticancer Research, 35(12), pp. 6457-6463. (PMID:26637856)

Richards, C.H. and Roxburgh, C.S.D. (2015) Surgical outcome in patients undergoing reversal of Hartmann's procedures: a multicentre study. Colorectal Disease, 17(3), pp. 242-249. (doi: 10.1111/codi.12807) (PMID:25331720)

Park, J. H. , McMillan, D. C. , Powell, A. G., Richards, C. H., Horgan, P. G. , Edwards, J. and Roxburgh, C. S.D. (2015) Evaluation of a tumor microenvironment-based prognostic score in primary operable colorectal cancer. Clinical Cancer Research, 21(4), pp. 882-888. (doi: 10.1158/1078-0432.CCR-14-1686) (PMID:25473000)

van Wyk, H.C. , Park, J. , Roxburgh, C. , Horgan, P. , Foulis, A. and McMillan, D. C. (2015) The role of tumour budding in predicting survival in patients with primary operable colorectal cancer: a systematic review. Cancer Treatment Reviews, 41(2), pp. 151-159. (doi: 10.1016/j.ctrv.2014.12.007) (PMID:25549950)

Park, J.H. , McMillan, D.C. , Horgan, P.G. and Roxburgh, C.S.D. (2015) The Clinical Utility of a Tumour Microenvironment-based Histopathological Score in Patients with Primary Operable Colorectal Cancer. Journal of Clinical Oncology 33(3_suppl). 2015 Gastrointestinal Cancers Symposium, San Francisco, CA, USA, 15-17 Jan 2015. p. 664. (doi: 10.1200/jco.2015.33.3_suppl.664)

Watt, D., Roxburgh, C. , White, M., Chan, J., Horgan, P. and McMillan, D. (2015) A survey of attitudes towards the clinical application of systemic inflammation based prognostic scores in cancer. Mediators of Inflammation, 2015, 842070. (doi: 10.1155/2015/842070) (PMID:26504363) (PMCID:PMC4609481)

2014

Park, J.H. , Roxburgh, C.S.D. and McMillan, D.C. (2014) Comment on ‘Tumour-infiltrating inflammation and prognosis in colorectal cancer: systematic review and meta-analysis’. British Journal of Cancer, 111(12), p. 2372. (doi: 10.1038/bjc.2014.296)

Roxburgh, C. S. D. , McMillan, D. C. , Richards, C. H., Atwan, M., Anderson, J., Harvey, T., Horgan, P. G. and Foulis, A. K. (2014) The clinical utility of the combination of T stage and venous invasion to predict survival in patients undergoing surgery for colorectal cancer. Annals of Surgery, 259(6), pp. 1156-1165. (doi: 10.1097/SLA.0000000000000229)

van Wyk, H. C. , Roxburgh, C. S. , Horgan, P. G. , Foulis, A. F. and McMillan, D. C. (2014) The detection and role of lymphatic and blood vessel invasion in predicting survival in patients with node negative operable primary colorectal cancer. Critical Reviews in Oncology/Hematology, 90(1), pp. 77-90. (doi: 10.1016/j.critrevonc.2013.11.004) (PMID:24332522)

Forrester, R., Guthrie, G.J.K., Orange, C., Horgan, P.G. , McMillan, D.C. and Roxburgh, C.S.D. (2014) Comparison of visual and automated assessment of tumour inflammatory infiltrates in patients with colorectal cancer. European Journal of Cancer, 50(3), pp. 544-552. (doi: 10.1016/j.ejca.2013.11.003) (PMID:24332571)

Park, J.H. , McMillan, D.C. , Horgan, P.G. and Roxburgh, C.S. (2014) The impact of anti-inflammatory agents on the outcome of patients with colorectal cancer. Cancer Treatment Reviews, 40(1), pp. 68-77. (doi: 10.1016/j.ctrv.2013.05.006)

Roxburgh, C.S. et al. (2014) A national survey of attitudes to research in Scottish General Surgery Trainees. Scottish Medical Journal, 59(1), pp. 9-15. (doi: 10.1177/0036933013518142) (PMID:24434857)

Elsberger, B., Roxburgh, C. S. and Horgan, P. G. (2014) Is there a role for surgical resections of hepatic breast cancer metastases? Hepato-Gastroenterology, 61(129), pp. 181-186. (PMID:24895817)

Park, J.H. , Richards, C.H., McMillan, D.C. , Horgan, P.G. and Roxburgh, C.S.D. (2014) The relationship between tumour stroma percentage, the tumour microenvironment and survival in patients with primary operable colorectal cancer. Annals of Oncology, 25(3), pp. 644-651. (doi: 10.1093/annonc/mdt593)

Richards, C. H., Roxburgh, C. S.D. , Powell, A. G., Foulis, A. K., Horgan, P. G. and McMillan, D. C. (2014) The clinical utility of the local inflammatory response in colorectal cancer. European Journal of Cancer, 50(2), pp. 309-319. (doi: 10.1016/j.ejca.2013.09.008) (PMID:24103145)

Roxburgh, C.S.D. and McMillan, D.C. (2014) Cancer and systemic inflammation: treat the tumour and treat the host. British Journal of Cancer, 110(6), pp. 1409-1412. (doi: 10.1038/bjc.2014.90)

2013

Mansouri, D. , McMillan, D.C. , Roxburgh, C.S.D. , Moug, S.J., Crighton, E.M. and Horgan, P.G. (2013) Flexible sigmoidoscopy following a positive faecal occult blood test within a bowel screening programme may reduce the detection of neoplasia. Colorectal Disease, 15(11), pp. 1375-1381. (doi: 10.1111/codi.12377)

Guthrie, G.J.K., Charles, K.A., Roxburgh, C.S.D. , Horgan, P.G. , McMillan, D.C. and Clarke, S.J. (2013) The systemic inflammation-based neutrophil–lymphocyte ratio: experience in patients with cancer. Critical Reviews in Oncology/Hematology, 88(1), pp. 218-230. (doi: 10.1016/j.critrevonc.2013.03.010)

Guthrie, G.J.K., Roxburgh, C.S.D. , Horgan, P.G. and McMillan, D.C. (2013) Does interleukin-6 link explain the link between tumour necrosis, local and systemic inflammatory responses and outcome in patients with colorectal cancer? Cancer Treatment Reviews, 39(1), pp. 89-96. (doi: 10.1016/j.ctrv.2012.07.003)

Guthrie, G.J.K., Roxburgh, C.S.D. , Farhan-Alanie, O.M., Horgan, P.G. and McMillan, D.C. (2013) Comparison of the prognostic value of longitudinal measurements of systemic inflammation in patients undergoing curative resection of colorectal cancer. British Journal of Cancer, 109(1), pp. 24-28. (doi: 10.1038/bjc.2013.330)

Guthrie, G.J.K., Roxburgh, C.S.D. , Richards, C.H., Horgan, P.G. and McMillan, D.C. (2013) Circulating IL-6 concentrations link tumour necrosis and systemic and local inflammatory responses in patients undergoing resection for colorectal cancer. British Journal of Cancer, 109(1), pp. 131-137. (doi: 10.1038/bjc.2013.291)

Mansouri, D. , McMillan, D.C. , Roxburgh, C.S.D. , Crighton, E.M. and Horgan, P.G. (2013) The impact of aspirin, statins and ACE-inhibitors on the presentation of colorectal neoplasia in a colorectal cancer screening programme. British Journal of Cancer, 109(1), pp. 249-256. (doi: 10.1038/bjc.2013.292)

Ramanathan, M.L., Roxburgh, C.S.D. , Guthrie, G.J.K., Orange, C., Talwar, D., Horgan, P.G. and McMillan, D.C. (2013) Is Perioperative systemic inflammation the result of insufficient cortisol production in patients with colorectal cancer? Annals of Surgical Oncology, 20(7), pp. 2172-2179. (doi: 10.1245/s10434-013-2943-4)

Roxburgh, C.S. , Richards, C.H., MacDonald, A.I., Powell, A.G., McGlynn, L.M., McMillan, D.C. , Horgan, P.G. , Edwards, J. and Shiels, P.G. (2013) The in situ local immune response, tumour senescence and proliferation in colorectal cancer. British Journal of Cancer, 109(8), pp. 2207-2216. (doi: 10.1038/bjc.2013.556)

2012

Roxburgh, C.S.D. and McMillan, D.C. (2012) The role of the in situ local inflammatory response in predicting recurrence and survival in patients with primary operable colorectal cancer. Cancer Treatment Reviews, 38(5), pp. 451-466. (doi: 10.1016/j.ctrv.2011.09.001)

Leung, E. Y.L. , Roxburgh, C. S. , Talwar, D., O'Reilly, D. S., McKee, R. F., Horgan, P. G. and McMillan, D. C. (2012) The relationships between plasma and red cell vitamin B2 and B6 concentrations and the systemic and local inflammatory responses in patients with colorectal cancer. Nutrition and Cancer, 64(4), pp. 515-520. (doi: 10.1080/01635581.2012.661512) (PMID:22439733)

Richards, C.H., Roxburgh, C.S.D. , Anderson, J.H., McKee, R.F., Foulis, A.K., Horgan, P.G. and McMillan, D.C. (2012) Prognostic value of tumour necrosis and host inflammatory responses in colorectal cancer. British Journal of Surgery, 99(2), pp. 287-294. (doi: 10.1002/bjs.7755)

Richards, C.H., Flegg, K.M., Roxburgh, C.S.D. , Going, J.J., Mohammed, Z., Horgan, P.G. and McMillan, D.C. (2012) The relationships between cellular components of the peritumoural inflammatory response, clinicopathological characteristics and survival in patients with primary operable colorectal cancer. British Journal of Cancer, 106(12), pp. 2010-2015. (doi: 10.1038/bjc.2012.211)

Roxburgh, C.S.D. , Richards, C.H., Moug, S.J., Foulis, A.K., McMillan, D.C. and Horgan, P.G. (2012) Determinants of short- and long-term outcome in patients undergoing simultaneous resection of colorectal cancer and synchronous colorectal liver metastases. International Journal of Colorectal Disease, 27(3), pp. 363-369. (doi: 10.1007/s00384-011-1339-9)

2011

Maxwell, F., McGlynn, L.M., Muir, H.C., Talwar, D., Benzeval, M., Robertson, T., Roxburgh, C.S., McMillan, D. , Horgan, P.G. and Shiels, P. (2011) Telomere attrition and decreased Fetuin A levels indicate accelerated biological ageing and are implicated in the pathogenesis of colorectal cancer. Clinical Cancer Research, 17(17), pp. 5573-5581. (doi: 10.1158/1078-0432.CCR-10-3271)

Roxburgh, C.S.D., Platt, J.J., Leitch, E.F., Kinsella, J., Horgan, P.G. and McMillan, D.C. (2011) Relationship between preoperative comorbidity, systemic inflammatory response, and survival in patients undergoing curative resection for colorectal cancer. Annals of Surgical Oncology, 18(4), pp. 997-1005. (doi: 10.1245/s10434-010-1410-8)

Roxburgh, C.S.D. and Foulis, A.K. (2011) The prognostic benefits of routine staining with elastica to increase detection of venous invasion in colorectal cancer specimens. Journal of Clinical Pathology, 64(12), p. 1142. (doi: 10.1136/jclinpath-2011-200284)

2010

Roxburgh, C.S.D., McMillan, D.C. , Anderson, J.H., McKee, R.F., Horgan, P.G. and Foulis, A.K. (2010) Elastica staining for venous invasion results in superior prediction of cancer specific survival in colorectal cancer. Annals of Surgery, 252(6), pp. 989-997. (doi: 10.1097/SLA.0b013e3181f1c60d)

Roxburgh, C.S.D. , Wallace, A.M., Guthrie, G., Horgan, P.G. and McMillan, D.C. (2010) Comparison of the prognostic value of tumour and patient related factors in patients undergoing potentially curative surgery for colon cancer. Colorectal Disease, 12(10), pp. 987-994. (doi: 10.1111/j.1463-1318.2009.01961.x) (PMID:19555389)

Moug, S.J., Smith, D., Leen, E., Roxburgh, C. and Horgan, P.G. (2010) Evidence for a synchronous operative approach in the treatment of colorectal cancer with hepatic metastases: a case matched study. European Journal of Surgical Oncology, 36(4), pp. 365-370. (doi: 10.1016/j.ejso.2009.11.007)

Roxburgh, C.S.D. and McMillan, D.C. (2010) Comparison of the Prognostic Value of Inflammation-Based Pathologic and Biochemical Criteria in Patients Undergoing Potentially Curative Resection for Colorectal Cancer Reply. Annals of Surgery, 251(2), pp. 390-391. (doi: 10.1097/SLA.0b013e3181cb8b6f)

Roxburgh, C.S.D. and McMillan, D.C. (2010) Role of systemic inflammatory response in predicting survival in patients with primary operable cancer. Future Oncology, 6(1), pp. 149-163. (doi: 10.2217/FON.09.136)[Book Review]

Leung, E.Y.L. , Roxburgh, C.S.D. , Leen, E. and Horgan, P. G. (2010) Combined resection and radiofrequency ablation for bilobar colorectal cancer liver metastases. Hepato-Gastroenterology, 57(97), pp. 41-46. (PMID:20422869)

2009

Roxburgh, C. and McMillan, D.C. (2009) Re: Ishizuka et al., systemic inflammatory response predicts postoperative outcome in patients with liver metastases from colorectal cancer. Journal of Surgical Oncology, 100(7), p. 616. (doi: 10.1002/jso.21379)

Roxburgh, C.S., Salmond, J.M., Horgan, P.G., Oien, K.A. and McMillan, D.C. (2009) Tumour inflammatory infiltrate predicts survival following curative resection for node-negative colorectal cancer. European Journal of Cancer, 45(12), pp. 2138-2145. (doi: 10.1016/j.ejca.2009.04.011)

Roxburgh, C.S.D. , Crozier, J.E.M., Maxwell, F., Foulis, A.K., Brown, J., McKee, R.F., Anderson, J.H., Horgan, P.G. and McMillan, D.C. (2009) Comparison of tumour-based (Petersen Index) and inflammation-based (Glasgow Prognostic Score) scoring systems in patients undergoing curative resection for colon cancer. British Journal of Cancer, 100(5), pp. 701-706. (doi: 10.1038/sj.bjc.6604926)

2008

Leung, E.Y.L. , Roxburgh, C.S.D., Leen, E. and Horgan, P.G. (2008) Combined resection and radiofrequency ablation for bilobar liver metastases. European Journal of Surgical Oncology, 34(10), p. 1168. (doi: 10.1016/j.ejso.2008.06.062)

Articles

Pennel, K., Dutton, L. , Melissourgou-Syka, L. , Roxburgh, C. , Birch, J. and Edwards, J. (2024) Novel radiation and targeted therapy combinations for improving rectal cancer outcomes. Expert Reviews in Molecular Medicine, (doi: 10.1017/erm.2024.15) (PMID:38623751) (Accepted for Publication)

Ingham,, A. R. et al. (2024) Robotic-assisted surgery for left sided colon and rectal resections is associated with reduction in the postoperative surgical stress response and improved short-term outcomes: a cohort study. Surgical Endoscopy, (doi: 10.1007/s00464-024-10749-3) (PMID:38498212)

Pennel, K. A.F. et al. (2024) JAK/STAT3 represents a therapeutic target for colorectal cancer patients with stromal-rich tumors. Journal of Experimental and Clinical Cancer Research, 43, 64. (doi: 10.1186/s13046-024-02958-4)

Hillson, L. V. S., McCulloch, A. K., Edwards, J. , Dunne, P. D., O'Cathail, S. M. and Roxburgh, C. S. (2024) Radiation-induced changes in gene expression in rectal cancer specimens. Clinical and Translational Oncology, (doi: 10.1007/s12094-023-03361-9) (PMID:38243085) (Early Online Publication)

Galbraith, N. J. et al. (2023) Effect of differing flap reconstruction strategies in perineal closure following advanced pelvic oncological resection: a retrospective cohort study. International Journal of Surgery, 109(11), pp. 3375-3382. (doi: 10.1097/JS9.0000000000000617) (PMID:37678294) (PMCID:PMC10651229)

Bradley, N.A., Walter, A., Wilson, A., Siddiqui, T., Roxburgh, C.S.D. , McMillan, D.C. and Guthrie, G.J.K. (2023) The relationship between CT-derived body composition, systemic inflammation, and survival in patients with abdominal aortic aneurysm. Journal of Vascular Surgery, 78(4), 937-944.e4. (doi: 10.1016/j.jvs.2023.06.012) (PMID:37385355)

McMahon, R. K., O'Cathail, S. M. , Nair, H., Steele, C. W. , Platt, J. J., Digby, M., McDonald, A. C., Horgan, P. G. and Roxburgh, C. S.D. (2023) The neoadjuvant rectal score and a novel magnetic resonance imaging based neoadjuvant rectal score are stage independent predictors of long-term outcome in locally advanced rectal cancer. Colorectal Disease, 25(9), pp. 1783-1794. (doi: 10.1111/codi.16667) (PMID:37485654)

Beach, C. et al. (2023) Innate immune receptor C5aR1 regulates cancer cell fate and can be targeted to improve radiotherapy in tumours with immunosuppressive microenvironments. Journal of Clinical Investigation, (Accepted for Publication)

Bradley, N.A., Walter, A., Wilson, A., Siddiqui, T., Roxburgh, C.S.D. , McMillan, D.C. and Guthrie, G.J.K. (2023) The prognostic value of pre-operative systemic inflammation-based scoring in patients undergoing endovascular repair of AAA. Journal of Vascular Surgery, 78(2), 362-369.e2. (doi: 10.1016/j.jvs.2023.04.018) (PMID:37086821)

Bradley, N. A., Walter, A., Dolan, R. , Wilson, A., Siddiqui, T., Roxburgh, C. S.D. , McMillan, D. C. and Guthrie, G. J.K. (2023) Evaluation of the prognostic value of computed tomography-derived body composition in patients undergoing endovascular aneurysm repair. Journal of Cachexia, Sarcopenia and Muscle, 14(4), pp. 1836-1847. (doi: 10.1002/jcsm.13262) (PMID:37221439) (PMCID:PMC10401537)

Bradley, N.A., Walter, A., Roxburgh, C.S.D. , McMillan, D.C. and Guthrie, G.J.K. (2023) The relationship between clinical frailty score, CT-derived body composition, systemic inflammation, and survival in patients with chronic limb threatening ischaemia. Annals of Vascular Surgery, (doi: 10.1016/j.avsg.2023.06.012) (PMID:37356659) (In Press)

Day, E. K., Galbraith, N. J. , Ward, H. J.T. and Roxburgh, C. S. (2023) Volume-outcome relationship in intra-abdominal robotic-assisted surgery: a systematic review. Journal of Robotic Surgery, 17(3), pp. 811-826. (doi: 10.1007/s11701-022-01461-2) (PMID:36315379)

Wood, C. S. et al. (2023) Spatially resolved transcriptomics deconvolutes prognostic histological subgroups in patients with colorectal cancer and synchronous liver metastases. Cancer Research, 83(8), pp. 1329-1344. (doi: 10.1158/0008-5472.CAN-22-2794) (PMID:37057593) (PMCID:PMC10102851)

Alexander, P.G., van Wyk, H.C. , Pennel, K.A.F., Hay, J., McMillan, D.C. , Horgan, P.G. , Roxburgh, C.S.D. , Edwards, J. and Park, J.H. (2023) The Glasgow Microenvironment Score and risk and site of recurrence in TNM I–III colorectal cancer. British Journal of Cancer, 128(4), pp. 556-567. (doi: 10.1038/s41416-022-02069-x) (PMID:36476660) (PMCID:PMC9938140)

Golder, A. M. , Sin, L. K. E., Alani, F., Dolan, R. , Mansouri, D. , Horgan, P. G. , McMillan, D. C. and Roxburgh, C. S. (2022) The relationship between the mode of presentation, CT-derived body composition, systemic inflammatory grade and survival in colon cancer. Journal of Cachexia, Sarcopenia and Muscle, 13(6), pp. 2863-2874. (doi: 10.1002/jcsm.13097) (PMID:36218135) (PMCID:PMC9745485)

Pennel, K. A. F. et al. (2022) CXCL8 expression is associated with advanced stage, right sidedness, and distinct histological features of colorectal cancer. Journal of Pathology: Clinical Research, 8(6), pp. 509-520. (doi: 10.1002/cjp2.290) (PMID:35879507) (PMCID:PMC9535100)

Bradley, N.A., Roxburgh, C.S.D. , McMillan, D.C. and Guthrie, G.J.K. (2022) The relationship between pre-operative psoas and skeletal muscle parameters and survival following endovascular aneurysm repair: a systematic review and meta-analysis. Scientific Reports, 12, 16663. (doi: 10.1038/s41598-022-20490-3) (PMID:36198699) (PMCID:PMC9534993)

Golder, A.M. , Mshihadani, A., McMillan, D.C. , Horgan, P.G. , Roxburgh, C.S. and Mansouri, D. (2022) Route to diagnosis of colorectal cancer and association with survival within the context of a bowel screening programme. Public Health, 211, pp. 53-61. (doi: 10.1016/j.puhe.2022.06.032) (PMID:36027788)

Metcalfe, K. H.M., Knight, K., McIntosh, S., Hunter, R., MacKay, C., McCabe, G., Sahni, D., Ramsay, G., Roxburgh, C. and Richards, C. (2022) Disease recurrence after right hemicolectomy in Scotland: Is there rationale to adopt complete mesocolic excision (CME)? Surgeon, 20(5), pp. 301-308. (doi: 10.1016/j.surge.2021.09.009) (PMID:34794905)

Alexander, P. G. et al. (2022) The relationship between the Glasgow Microenvironment Score and markers of epithelial-mesenchymal transition in TNM II-III colorectal cancer. Human Pathology, 127, pp. 1-11. (doi: 10.1016/j.humpath.2022.05.012) (PMID:35623467)

Cheong, C. M., Golder, A. , Horgan, P. , Roxburgh, C. and McMillan, D. (2022) Relationship between pre‑operative glycated haemoglobin and surgical site infection in patients undergoing elective colon cancer surgery. Oncology Letters, 24(3), 296. (doi: 10.3892/ol.2022.13416) (PMID:35949622) (PMCID:PMC9353220)

Gould, L. E., Pring, E. T., Drami, I., Moorghen, M., Naghibi, M., Jenkins, J. T., Steele, C. W. and Roxburgh, C. S.D. (2022) A systematic review of the pathological determinants of outcome following resection by pelvic exenteration of locally advanced and locally recurrent rectal cancer. International Journal of Surgery, 104, 106738. (doi: 10.1016/j.ijsu.2022.106738) (PMID:35781038)

McGovern, J., Golder, A. M. , Dolan, R. D. , Roxburgh, C. S.D. , Horgan, P. G. and McMillan, D. C. (2022) The combination of computed tomography-derived muscle mass and muscle density and relationship with clinicopathological characteristics and survival in patients undergoing potentially curative surgery for colorectal cancer. JCSM Clinical Reports, 7(3), pp. 65-76. (doi: 10.1002/crt2.54)

Ross, F. A., Park, J. H. , Mansouri, D. , Combet, E. , Horgan, P. G. , McMillan, D. C. and Roxburgh, C. S.D. (2022) The role of faecal calprotectin in diagnosis and staging of colorectal neoplasia: a systematic review and meta-analysis. BMC Gastroenterology, 22, 176. (doi: 10.1186/s12876-022-02220-1) (PMID:35397505) (PMCID:PMC8994317)

Golder, A. M. , McMillan, D. C. , Horgan, P. G. and Roxburgh, C. S.D. (2022) Determinants of emergency presentation in patients with colorectal cancer: a systematic review and meta-analysis. Scientific Reports, 12, 4366. (doi: 10.1038/s41598-022-08447-y) (PMID:35288664) (PMCID:PMC8921241)

Ross, F. A., Park, J. H. , Mansouri, D. , Little, C., Di Rollo, D. G., Combet, E. , Van Wyk, H. , Horgan, P. G. , McMillan, D. C. and Roxburgh, C. S. D. (2022) The role of faecal calprotectin in the identification of colorectal neoplasia in patients attending for screening colonoscopy. Colorectal Disease, 24(2), pp. 188-196. (doi: 10.1111/codi.15942) (PMID:34614299)

Zaborowski, A. M. et al. (2022) Microsatellite instability in young patients with rectal cancer: molecular findings and treatment response. British Journal of Surgery, 109(3), pp. 251-255. (doi: 10.1093/bjs/znab437) (PMID:35030243)

Cheong, C. M., Golder, A. M. , Horgan, P. D. , McMillan, D. C. and Roxburgh, C. S.D. (2022) Evaluation of clinical prognostic variables on short-term outcome for colorectal cancer surgery: an overview and minimum dataset. Cancer Treatment and Research Communications, 31, 100544. (doi: 10.1016/j.ctarc.2022.100544) (PMID:35248885)

Hernon, J. et al. (2021) SupPoRtive Exercise Programmes for Accelerating REcovery after major ABdominal Cancer surgery trial (PREPARE-ABC): pilot phase of a multicentre randomised controlled trial. Colorectal Disease, 23(11), pp. 3008-3022. (doi: 10.1111/codi.15856) (PMID:34355484)

Knight, K. A., Drami, I., McMillan, D. C. , Horgan, P. G. , Park, J. H. , Jenkins, J. T. and Roxburgh, C. S.D. (2021) Vascular calcification and response to neoadjuvant therapy in locally advanced rectal cancer: an exploratory study. Journal of Cancer Research and Clinical Oncology, 147(11), pp. 3409-3420. (doi: 10.1007/s00432-021-03570-1) (PMID:33710416) (PMCID:PMC8484095)

Zaborowski, A. M. et al. (2021) Characteristics of early-onset vs late-onset colorectal cancer. JAMA Surgery, 156(9), pp. 865-874. (doi: 10.1001/jamasurg.2021.2380) (PMID:34190968)

Hanna, C. R. et al. (2021) Durvalumab (MEDI 4736) in combination with extended neoadjuvant regimens in rectal cancer: a study protocol of a randomised phase II trial (PRIME-RT). Radiation Oncology, 16, 163. (doi: 10.1186/s13014-021-01888-1) (PMID:34446053)

Knight, K. A., Hon Fei, C., Boland, K. F., Dolan, D. R., Golder, A. M. , McMillan, D. C. , Horgan, P. G. , Black, D. H., Park, J. H. and Roxburgh, C. S.D. (2021) Aortic calcification is associated with non-infective rather than infective postoperative complications following colorectal cancer resection: an observational cohort study. European Radiology, 31(6), pp. 4319-4329. (doi: 10.1007/s00330-020-07189-7) (PMID:33201280)

Al-Badran, S. S.F. et al. (2021) Relationship between immune checkpoint proteins, tumour microenvironment characteristics, and prognosis in primary operable colorectal cancer. Journal of Pathology: Clinical Research, 7(2), pp. 121-134. (doi: 10.1002/cjp2.193) (PMID:33338327)

Alexander, P.G. et al. (2021) The Glasgow Microenvironment Score associates with prognosis and adjuvant chemotherapy response in colorectal cancer. British Journal of Cancer, 124, pp. 786-796. (doi: 10.1038/s41416-020-01168-x) (PMID:33223535)

Knight, K., Al-Wahid, M., Choong, J. X., Burton, K., Lindsay, R., McKee, R. F., Anderson, J. H. and Roxburgh, C. S.D. (2021) Multidisciplinary management of anal intraepithelial neoplasia and rate of progression to cancer: a retrospective cohort study. European Journal of Surgical Oncology, 47(2), pp. 304-310. (doi: 10.1016/j.ejso.2020.08.011) (PMID:32873453)

Alhayyan, A. M. , McSorley, S. T. , Kearns, R. J. , Horgan, P. G. , Roxburgh, C. S.D. and McMillan, D. C. (2021) The effect of anesthesia on the magnitude of the postoperative systemic inflammatory response in patients undergoing elective surgery for colorectal cancer in the context of an enhanced recovery pathway: A prospective cohort study. Medicine, 100(2), e23997. (doi: 10.1097/MD.0000000000023997) (PMID:33466141) (PMCID:PMC7808526)

Knight, K., Choong, J.X., McKee, R.F., Anderson, J.H., Horgan, P.G. , McMillan, D.C. , McDonald, A. and Roxburgh, C.S. (2021) The influence of systemic inflammation on treatment response and survival in anal squamous cell cancer. Clinical Oncology, 33(1), e22-e30. (doi: 10.1016/j.clon.2020.06.010) (PMID:32709540)

Hanna, C. R. , O'Cathail, S. M. , Graham, J., Adams, R. and Roxburgh, C. S.D. (2021) Immune checkpoint inhibition as a strategy in the neoadjuvant treatment of locally advanced rectal cancer. Journal of Immunotherapy and Precision Oncology, 4(2), (doi: 10.36401/JIPO-20-31)

Dolan, R. D. , Alwahid, M., McSorley, S. T. , Park, J. H. , Stevenson, R. P., Roxburgh, C. S. , Horgan, P. G. and McMillan, D. C. (2020) A comparison of the prognostic value of composite ratios and cumulative scores in patients with operable rectal cancer. Scientific Reports, 10, 17965. (doi: 10.1038/s41598-020-73909-0) (PMID:33087753) (PMCID:PMC7578034)

Roseweir, A. K. et al. (2020) Histological phenotypic subtypes predict recurrence risk and response to adjuvant chemotherapy in patients with stage III colorectal cancer. Journal of Pathology: Clinical Research, 6(4), pp. 283-296. (doi: 10.1002/cjp2.171) (PMID:32401426) (PMCID:PMC7578335)

Golder, A.M. , Steele, C.W. , Conn, D., Mackay, G.J., McMillan, D.C. , Horgan, P.G. , Roxburgh, C.S. and McSorley, S.T. (2020) Authors' reply: Effect of preoperative oral antibiotics in combination with mechanical bowel preparation on inflammatory response and short-term outcomes following left-sided colonic and rectal resections. BJS Open, 4(4), pp. 730-731. (doi: 10.1002/bjs5.50286) (PMID:32297454) (PMCID:PMC7397349)

Park, J. H. , Fuglestad, A. J., Køstner, A. H., Oliwa, A., Graham, J., Horgan, P. G. , Roxburgh, C. S.D. , Kersten, C. and McMillan, D. C. (2020) Systemic inflammation and outcome in 2295 patients with stage I-III colorectal cancer from Scotland and Norway: First results from the ScotScan Colorectal Cancer Group. Annals of Surgical Oncology, 27, pp. 2784-2794. (doi: 10.1245/s10434-020-08268-1) (PMID:32248375) (PMCID:PMC7334267)

Cercek, A. et al. (2020) Mismatch repair-deficient rectal cancer and resistance to neoadjuvant chemotherapy. Clinical Cancer Research, 26(13), pp. 3271-3279. (doi: 10.1158/1078-0432.CCR-19-3728) (PMID:32144135) (PMCID:PMC7348681)

McSorley, S. T. , Anderson, J. H., Whittle, T., Roxburgh, C. S. , Horgan, P. G. , McMillan, D. C. and Steele, C. W. (2020) The impact of preoperative systemic inflammation on the efficacy of intravenous iron infusion to correct anaemia prior to surgery for colorectal cancer. Perioperative Medicine, 9, 17. (doi: 10.1186/s13741-020-00146-4) (PMID:32537137) (PMCID:PMC7288411)

ALHAYYAN, A. , McSorley, S. T. , Kearns, R. J. , Horgan, P. G. , Roxburgh, C. S.D. and McMillan, D. C. (2020) The relationship between anaesthetic technique, clinicopathological characteristics and the magnitude of the postoperative systemic inflammatory response in patients undergoing elective surgery for colon cancer. PLoS ONE, 15(4), e0228580. (doi: 10.1371/journal.pone.0228580) (PMID:32348308) (PMCID:PMC7190171)

Alhayyan, A. , McSorley, S. , Roxburgh, C. , Kearns, R. , Horgan, P. and McMillan, D. (2020) The effect of anesthesia on the postoperative systemic inflammatory response in patients undergoing surgery: a systematic review and meta-analysis. Surgery Open Science, 2(1), pp. 1-21. (doi: 10.1016/j.sopen.2019.06.001) (PMID:32754703) (PMCID:PMC7391900)

Chapman, S.J. et al. (2020) Safety and efficacy of non‐steroidal anti‐inflammatory drugs to reduce ileus after colorectal surgery. British Journal of Surgery, 107(2), e161-e169. (doi: 10.1002/bjs.11326) (PMID:31595986)

Knight, K.A., Horgan, P.G. , McMillan, D.C. , Roxburgh, C.S.D. and Park, J.H. (2020) The relationship between aortic calcification and anastomotic leak following gastrointestinal resection: a systematic review. International Journal of Surgery, 73, pp. 42-49. (doi: 10.1016/j.ijsu.2019.11.023) (PMID:31765846)

McSorley, S. T. , Tham, A., Dolan, R. D. , Steele, C. W. , Ramsingh, J., Roxburgh, C. , Horgan, P. G. and McMillan, D. C. (2020) Perioperative blood transfusion is associated with the postoperative systemic inflammatory response and poorer outcomes following surgery for colorectal cancer. Annals of Surgical Oncology, 27, pp. 833-843. (doi: 10.1245/s10434-019-07984-7) (PMID:31664621) (PMCID:PMC7000540)

Golder, A.M. , Steele, C.W. , Conn, D., Mackay, G.J., McMillan, D.C. , Horgan, P.G. , Roxburgh, C.S. and McSorley, S.T. (2019) Effect of preoperative oral antibiotics in combination with mechanical bowel preparation on inflammatory response and short‐term outcomes following left‐sided colonic and rectal resections. BJS Open, 3(6), pp. 830-839. (doi: 10.1002/bjs5.50224) (PMID:31832590) (PMCID:PMC6887908)

Golder, A. M. , McSorley, S. T. , Kearns, R. J. , McMillan, D. C. , Horgan, P. G. and Roxburgh, C. S. (2019) Attitudes towards the use of perioperative steroids in resectional colorectal cancer surgery in the UK: a qualitative study. Annals of Medicine and Surgery, 48, pp. 23-28. (doi: 10.1016/j.amsu.2019.10.007) (PMID:31687135) (PMCID:PMC6820077)

Kroon, H. M. et al. (2019) Palliative pelvic exenteration: A systematic review of patient-centered outcomes. European Journal of Surgical Oncology, 45(10), pp. 1787-1795. (doi: 10.1016/j.ejso.2019.06.011) (PMID:31255441)

Roxburgh, C.S.D. et al. (2019) Changes in the multidisciplinary management of rectal cancer from 2009 to 2015 and associated improvements in short‐term outcomes. Colorectal Disease, 21(10), pp. 1140-1150. (doi: 10.1111/codi.14713) (PMID:31108012) (PMCID:PMC6773478)

Jackstadt, R. et al. (2019) Epithelial NOTCH signaling rewires the tumor microenvironment of colorectal cancer to drive poor-prognosis subtypes and metastasis. Cancer Cell, 36(3), 319-336.e7. (doi: 10.1016/j.ccell.2019.08.003) (PMID:31526760) (PMCID:PMC6853173)

Park, J. H. , van Wyk, H. , McMillan, D. C. , Edwards, J. , Orange, C., Horgan, P. G. and Roxburgh, C. S.D. (2019) Pre-operative, biopsy-based assessment of the tumour microenvironment in patients with primary operable colorectal cancer. Journal of Pathology: Clinical Research, 6(1), pp. 30-39. (doi: 10.1002/cjp2.143) (PMID:31486287) (PMCID:PMC6966701)

McSorley, S. T. , Dolan, R. D. , Roxburgh, C. S.D. , Horgan, P. G. , MacKay, G. J. and McMillan, D. C. (2019) Possible dose dependent effect of perioperative dexamethasone and laparoscopic surgery on the postoperative systemic inflammatory response and complications following surgery for colon cancer. European Journal of Surgical Oncology, 45(9), pp. 1613-1618. (doi: 10.1016/j.ejso.2019.05.020) (PMID:31130339)

McSorley, S. T. , Tham, A., Steele, C. W. , Dolan, R. D. , Roxburgh, C. S.D. , Horgan, P. G. and McMillan, D. C. (2019) Quantitative data on red cell measures of iron status and their relation to the magnitude of the systemic inflammatory response and survival in patients with colorectal cancer. European Journal of Surgical Oncology, 45(7), pp. 1205-1211. (doi: 10.1016/j.ejso.2019.02.027) (PMID:30850153)

Smith, J. J. et al. (2019) Assessment of a watch-and-wait strategy for rectal cancer in patients with a complete response after neoadjuvant therapy. JAMA Oncology, 5(4), e185896. (doi: 10.1001/jamaoncol.2018.5896) (PMID:30629084) (PMCID:PMC6459120)

Roxburgh, C. S.D. et al. (2019) Role of the interval from completion of neoadjuvant therapy to surgery in postoperative morbidity in patients with locally advanced rectal cancer. Annals of Surgical Oncology, 26, pp. 2019-2027. (doi: 10.1245/s10434-019-07340-9) (PMID:30963399) (PMCID:PMC6579536)

McSorley, S. , Johnstone, M., Steele, C. W. , Roxburgh, C. S.D. , Horgan, P. G. , McMillan, D. C. and Mansouri, D. (2019) Normocytic anaemia is associated with systemic inflammation and poorer survival in patients with colorectal cancer treated with curative intent. International Journal of Colorectal Disease, 34(3), pp. 401-408. (doi: 10.1007/s00384-018-3211-7) (PMID:30515556)

Roseweir, A.K. et al. (2019) A novel tumor-based epithelial-to-mesenchymal transition score that associates with prognosis and metastasis in patients with stage II/III colorectal cancer. International Journal of Cancer, 144(1), pp. 150-159. (doi: 10.1002/ijc.31739) (PMID:29992570)

Roxburgh, C. S. and Weiser, M. R. (2018) Selective use of radiation for locally advanced rectal cancer: one size does not fit all. Minerva Chirurgica, 73(6), pp. 592-600. (doi: 10.23736/S0026-4733.18.07791-X) (PMID:29806758)

Roxburgh, C. S. , Fenig, Y. M., Cercek, A., Shia, J., Rassam, R. M., Paty, P. B. and Nash, G. M. (2018) Outcomes of low-grade appendiceal mucinous neoplasms with remote acellular mucinous peritoneal deposits. Annals of Surgical Oncology, 26, pp. 118-124. (doi: 10.1245/s10434-018-7003-7) (PMID:30421044) (PMCID:PMC6339600)

Park, J. H. et al. (2018) Staging the tumor and staging the host: A two centre, two country comparison of systemic inflammatory responses of patients undergoing resection of primary operable colorectal cancer. American Journal of Surgery, 216(3), pp. 458-464. (doi: 10.1016/j.amjsurg.2017.08.044) (PMID:28967380)

Dolan, R. D. , McSorley, S. T. , Park, J. H. , Watt, D. G. , Roxburgh, C. S. , Horgan, P. G. and McMillan, D. C. (2018) The prognostic value of systemic inflammation in patients undergoing surgery for colon cancer: comparison of composite ratios and cumulative scores. British Journal of Cancer, 119(1), pp. 40-51. (doi: 10.1038/s41416-018-0095-9) (PMID:29789606)

McSorley, S. T. , Roxburgh, C. S.D. , Horgan, P. G. and McMillan, D. C. (2018) The relationship between cardiopulmonary exercise test variables, the systemic inflammatory response, and complications following surgery for colorectal cancer. Perioperative Medicine, 7(1), 11. (doi: 10.1186/s13741-018-0093-8) (PMID:29983927) (PMCID:PMC6003031)

Cercek, A. et al. (2018) Adoption of total neoadjuvant therapy for locally advanced rectal cancer. JAMA Oncology, 4(6), e180071. (doi: 10.1001/jamaoncol.2018.0071) (PMID:29566109) (PMCID:PMC5885165)

Patel, M., McSorley, S. T. , Park, J. H. , Roxburgh, C. S.D. , Edwards, J. , Horgan, P. G. and McMillan, D. C. (2018) The relationship between right-sided tumour location, tumour microenvironment, systemic inflammation, adjuvant therapy and survival in patients undergoing surgery for colon and rectal cancer. British Journal of Cancer, 118(5), pp. 705-712. (doi: 10.1038/bjc.2017.441) (PMID:29337962) (PMCID:PMC5846060)

Roxburgh, C. S. , Shia, J., Vakiani, E., Daniel, T. and Weiser, M. R. (2018) Potential immune priming of the tumor microenvironment with FOLFOX chemotherapy in locally advanced rectal cancer. OncoImmunology, 7(6), e1435227. (doi: 10.1080/2162402x.2018.1435227) (PMID:29872576)

Mcsorley, S. T. , Roxburgh, C. S.D. , Horgan, P. G. and McMillan, D. C. (2017) The impact of preoperative dexamethasone on the magnitude of the postoperative systemic inflammatory response and complications following surgery for colorectal cancer. Annals of Surgical Oncology, 24(8), pp. 2104-2112. (doi: 10.1245/s10434-017-5817-3) (PMID:28251379)

Park, J. H. , Roxburgh, C. S.D. , Edwards, J. , Horgan, P. G. and McMillan, D. C. (2017) In reply to "Hynes S.O. et al. Back to the future: routine morphological assessment of the tumour microenvironment is prognostic in stage II/III colon cancer in a large population-based study". Histopathology, 71(2), pp. 326-327. (doi: 10.1111/his.13195) (PMID:28226191)

Park, J.H. , Van Wyk, H. , Roxburgh, C.S.D. , Horgan, P.G. , Edwards, J. and McMillan, D.C. (2017) Tumour invasiveness, the local and systemic environment and the basis of staging systems in colorectal cancer. British Journal of Cancer, 116, pp. 1444-1450. (doi: 10.1038/bjc.2017.108)

McSorley, S. T. , Roxburgh, C. S. , Horgan, P. G. and McMillan, D. C. (2017) Re: Dexamethasone versus standard treatment for postoperative nausea and vomiting in gastrointestinal surgery: randomised controlled trial (DREAMS Trial). British Medical Journal, 357, j1455.

Park, J. H. , Van Wyk, H. C., McMillan, D. C. , Quinn, J. A. , Clark, J., Roxburgh, C. , Horgan, P. G. and Edwards, J. (2017) Signal transduction and activator of transcription-3 (STAT3) in patients with colorectal cancer: associations with the phenotypic features of the tumour and host. Clinical Cancer Research, 23(7), pp. 1698-1709. (doi: 10.1158/1078-0432.CCR-16-1416) (PMID:27678454)

Little, C. H., Combet, E. , McMillan, D. C. , Horgan, P. G. and Roxburgh, C. S.D. (2017) The role of dietary polyphenols in the moderation of the inflammatory response in early stage colorectal cancer. Critical Reviews in Food Science and Nutrition, 57(11), pp. 2310-2320. (doi: 10.1080/10408398.2014.997866)

McSorley, S. T. , Dolan, R. D. , Roxburgh, C. S.D. , McMillan, D. C. and Horgan, P. G. (2017) How and why systemic inflammation worsens quality of life in patients with advanced cancer. Expert Review of Quality of Life in Cancer Care, 2(3), pp. 167-175. (doi: 10.1080/23809000.2017.1331705)

Patel, S. V. et al. (2016) Distance to the anal verge is associated with pathologic complete response to neoadjuvant therapy in locally advanced rectal cancer. Journal of Surgical Oncology, 114(5), pp. 637-641. (doi: 10.1002/jso.24358) (PMID:27641934) (PMCID:PMC5516624)

Park, J. H. , McMillan, D. C. , Edwards, J. , Horgan, P. G. and Roxburgh, C. S.D. (2016) Comparison of the prognostic value of measures of the tumor inflammatory cell infiltrate and tumor-associated stroma in patients with primary operable colorectal cancer. OncoImmunology, 5(3), e1098801. (doi: 10.1080/2162402X.2015.1098801)

Park, J. H. , Watt, D. G., Roxburgh, C. S.D. , Horgan, P. G. and McMillan, D. C. (2016) Colorectal cancer, systemic inflammation, and outcome: staging the tumor and staging the host. Annals of Surgery, 263(2), pp. 326-336. (doi: 10.1097/SLA.0000000000001122) (PMID:25575264)

Roxburgh, C. and McMillan, D. (2016) Therapeutics targeting innate immune/inflammatory responses through the interleukin-6/JAK/STAT signal transduction pathway in patients with cancer. Translational Research, 167(1), pp. 61-66. (doi: 10.1016/j.trsl.2015.08.013) (PMID:26432924)

Park, J. H. , Powell, A. G., Roxburgh, C. S.D. , Horgan, P. G. , McMillan, D. c. and Edwards, J. (2016) Mismatch repair status in patients with primary operable colorectal cancer: associations with the local and systemic tumour environment. British Journal of Cancer, 114, pp. 562-570. (doi: 10.1038/bjc.2016.17) (PMID:26859693)

VAN Wyk, H. C., Foulis, A., Roxburgh, C. , Orange, C., Horgan, P. and McMillan, D. (2015) Comparison of methods to identify lymphatic and blood vessel invasion and their prognostic value in patients with primary operable colorectal cancer. Anticancer Research, 35(12), pp. 6457-6463. (PMID:26637856)

Richards, C.H. and Roxburgh, C.S.D. (2015) Surgical outcome in patients undergoing reversal of Hartmann's procedures: a multicentre study. Colorectal Disease, 17(3), pp. 242-249. (doi: 10.1111/codi.12807) (PMID:25331720)

Park, J. H. , McMillan, D. C. , Powell, A. G., Richards, C. H., Horgan, P. G. , Edwards, J. and Roxburgh, C. S.D. (2015) Evaluation of a tumor microenvironment-based prognostic score in primary operable colorectal cancer. Clinical Cancer Research, 21(4), pp. 882-888. (doi: 10.1158/1078-0432.CCR-14-1686) (PMID:25473000)

van Wyk, H.C. , Park, J. , Roxburgh, C. , Horgan, P. , Foulis, A. and McMillan, D. C. (2015) The role of tumour budding in predicting survival in patients with primary operable colorectal cancer: a systematic review. Cancer Treatment Reviews, 41(2), pp. 151-159. (doi: 10.1016/j.ctrv.2014.12.007) (PMID:25549950)

Watt, D., Roxburgh, C. , White, M., Chan, J., Horgan, P. and McMillan, D. (2015) A survey of attitudes towards the clinical application of systemic inflammation based prognostic scores in cancer. Mediators of Inflammation, 2015, 842070. (doi: 10.1155/2015/842070) (PMID:26504363) (PMCID:PMC4609481)

Park, J.H. , Roxburgh, C.S.D. and McMillan, D.C. (2014) Comment on ‘Tumour-infiltrating inflammation and prognosis in colorectal cancer: systematic review and meta-analysis’. British Journal of Cancer, 111(12), p. 2372. (doi: 10.1038/bjc.2014.296)

Roxburgh, C. S. D. , McMillan, D. C. , Richards, C. H., Atwan, M., Anderson, J., Harvey, T., Horgan, P. G. and Foulis, A. K. (2014) The clinical utility of the combination of T stage and venous invasion to predict survival in patients undergoing surgery for colorectal cancer. Annals of Surgery, 259(6), pp. 1156-1165. (doi: 10.1097/SLA.0000000000000229)

van Wyk, H. C. , Roxburgh, C. S. , Horgan, P. G. , Foulis, A. F. and McMillan, D. C. (2014) The detection and role of lymphatic and blood vessel invasion in predicting survival in patients with node negative operable primary colorectal cancer. Critical Reviews in Oncology/Hematology, 90(1), pp. 77-90. (doi: 10.1016/j.critrevonc.2013.11.004) (PMID:24332522)

Forrester, R., Guthrie, G.J.K., Orange, C., Horgan, P.G. , McMillan, D.C. and Roxburgh, C.S.D. (2014) Comparison of visual and automated assessment of tumour inflammatory infiltrates in patients with colorectal cancer. European Journal of Cancer, 50(3), pp. 544-552. (doi: 10.1016/j.ejca.2013.11.003) (PMID:24332571)

Park, J.H. , McMillan, D.C. , Horgan, P.G. and Roxburgh, C.S. (2014) The impact of anti-inflammatory agents on the outcome of patients with colorectal cancer. Cancer Treatment Reviews, 40(1), pp. 68-77. (doi: 10.1016/j.ctrv.2013.05.006)

Roxburgh, C.S. et al. (2014) A national survey of attitudes to research in Scottish General Surgery Trainees. Scottish Medical Journal, 59(1), pp. 9-15. (doi: 10.1177/0036933013518142) (PMID:24434857)

Elsberger, B., Roxburgh, C. S. and Horgan, P. G. (2014) Is there a role for surgical resections of hepatic breast cancer metastases? Hepato-Gastroenterology, 61(129), pp. 181-186. (PMID:24895817)

Park, J.H. , Richards, C.H., McMillan, D.C. , Horgan, P.G. and Roxburgh, C.S.D. (2014) The relationship between tumour stroma percentage, the tumour microenvironment and survival in patients with primary operable colorectal cancer. Annals of Oncology, 25(3), pp. 644-651. (doi: 10.1093/annonc/mdt593)

Richards, C. H., Roxburgh, C. S.D. , Powell, A. G., Foulis, A. K., Horgan, P. G. and McMillan, D. C. (2014) The clinical utility of the local inflammatory response in colorectal cancer. European Journal of Cancer, 50(2), pp. 309-319. (doi: 10.1016/j.ejca.2013.09.008) (PMID:24103145)

Roxburgh, C.S.D. and McMillan, D.C. (2014) Cancer and systemic inflammation: treat the tumour and treat the host. British Journal of Cancer, 110(6), pp. 1409-1412. (doi: 10.1038/bjc.2014.90)

Mansouri, D. , McMillan, D.C. , Roxburgh, C.S.D. , Moug, S.J., Crighton, E.M. and Horgan, P.G. (2013) Flexible sigmoidoscopy following a positive faecal occult blood test within a bowel screening programme may reduce the detection of neoplasia. Colorectal Disease, 15(11), pp. 1375-1381. (doi: 10.1111/codi.12377)

Guthrie, G.J.K., Charles, K.A., Roxburgh, C.S.D. , Horgan, P.G. , McMillan, D.C. and Clarke, S.J. (2013) The systemic inflammation-based neutrophil–lymphocyte ratio: experience in patients with cancer. Critical Reviews in Oncology/Hematology, 88(1), pp. 218-230. (doi: 10.1016/j.critrevonc.2013.03.010)

Guthrie, G.J.K., Roxburgh, C.S.D. , Horgan, P.G. and McMillan, D.C. (2013) Does interleukin-6 link explain the link between tumour necrosis, local and systemic inflammatory responses and outcome in patients with colorectal cancer? Cancer Treatment Reviews, 39(1), pp. 89-96. (doi: 10.1016/j.ctrv.2012.07.003)

Guthrie, G.J.K., Roxburgh, C.S.D. , Farhan-Alanie, O.M., Horgan, P.G. and McMillan, D.C. (2013) Comparison of the prognostic value of longitudinal measurements of systemic inflammation in patients undergoing curative resection of colorectal cancer. British Journal of Cancer, 109(1), pp. 24-28. (doi: 10.1038/bjc.2013.330)

Guthrie, G.J.K., Roxburgh, C.S.D. , Richards, C.H., Horgan, P.G. and McMillan, D.C. (2013) Circulating IL-6 concentrations link tumour necrosis and systemic and local inflammatory responses in patients undergoing resection for colorectal cancer. British Journal of Cancer, 109(1), pp. 131-137. (doi: 10.1038/bjc.2013.291)

Mansouri, D. , McMillan, D.C. , Roxburgh, C.S.D. , Crighton, E.M. and Horgan, P.G. (2013) The impact of aspirin, statins and ACE-inhibitors on the presentation of colorectal neoplasia in a colorectal cancer screening programme. British Journal of Cancer, 109(1), pp. 249-256. (doi: 10.1038/bjc.2013.292)

Ramanathan, M.L., Roxburgh, C.S.D. , Guthrie, G.J.K., Orange, C., Talwar, D., Horgan, P.G. and McMillan, D.C. (2013) Is Perioperative systemic inflammation the result of insufficient cortisol production in patients with colorectal cancer? Annals of Surgical Oncology, 20(7), pp. 2172-2179. (doi: 10.1245/s10434-013-2943-4)

Roxburgh, C.S. , Richards, C.H., MacDonald, A.I., Powell, A.G., McGlynn, L.M., McMillan, D.C. , Horgan, P.G. , Edwards, J. and Shiels, P.G. (2013) The in situ local immune response, tumour senescence and proliferation in colorectal cancer. British Journal of Cancer, 109(8), pp. 2207-2216. (doi: 10.1038/bjc.2013.556)

Roxburgh, C.S.D. and McMillan, D.C. (2012) The role of the in situ local inflammatory response in predicting recurrence and survival in patients with primary operable colorectal cancer. Cancer Treatment Reviews, 38(5), pp. 451-466. (doi: 10.1016/j.ctrv.2011.09.001)

Leung, E. Y.L. , Roxburgh, C. S. , Talwar, D., O'Reilly, D. S., McKee, R. F., Horgan, P. G. and McMillan, D. C. (2012) The relationships between plasma and red cell vitamin B2 and B6 concentrations and the systemic and local inflammatory responses in patients with colorectal cancer. Nutrition and Cancer, 64(4), pp. 515-520. (doi: 10.1080/01635581.2012.661512) (PMID:22439733)

Richards, C.H., Roxburgh, C.S.D. , Anderson, J.H., McKee, R.F., Foulis, A.K., Horgan, P.G. and McMillan, D.C. (2012) Prognostic value of tumour necrosis and host inflammatory responses in colorectal cancer. British Journal of Surgery, 99(2), pp. 287-294. (doi: 10.1002/bjs.7755)

Richards, C.H., Flegg, K.M., Roxburgh, C.S.D. , Going, J.J., Mohammed, Z., Horgan, P.G. and McMillan, D.C. (2012) The relationships between cellular components of the peritumoural inflammatory response, clinicopathological characteristics and survival in patients with primary operable colorectal cancer. British Journal of Cancer, 106(12), pp. 2010-2015. (doi: 10.1038/bjc.2012.211)

Roxburgh, C.S.D. , Richards, C.H., Moug, S.J., Foulis, A.K., McMillan, D.C. and Horgan, P.G. (2012) Determinants of short- and long-term outcome in patients undergoing simultaneous resection of colorectal cancer and synchronous colorectal liver metastases. International Journal of Colorectal Disease, 27(3), pp. 363-369. (doi: 10.1007/s00384-011-1339-9)

Maxwell, F., McGlynn, L.M., Muir, H.C., Talwar, D., Benzeval, M., Robertson, T., Roxburgh, C.S., McMillan, D. , Horgan, P.G. and Shiels, P. (2011) Telomere attrition and decreased Fetuin A levels indicate accelerated biological ageing and are implicated in the pathogenesis of colorectal cancer. Clinical Cancer Research, 17(17), pp. 5573-5581. (doi: 10.1158/1078-0432.CCR-10-3271)

Roxburgh, C.S.D., Platt, J.J., Leitch, E.F., Kinsella, J., Horgan, P.G. and McMillan, D.C. (2011) Relationship between preoperative comorbidity, systemic inflammatory response, and survival in patients undergoing curative resection for colorectal cancer. Annals of Surgical Oncology, 18(4), pp. 997-1005. (doi: 10.1245/s10434-010-1410-8)

Roxburgh, C.S.D. and Foulis, A.K. (2011) The prognostic benefits of routine staining with elastica to increase detection of venous invasion in colorectal cancer specimens. Journal of Clinical Pathology, 64(12), p. 1142. (doi: 10.1136/jclinpath-2011-200284)

Roxburgh, C.S.D., McMillan, D.C. , Anderson, J.H., McKee, R.F., Horgan, P.G. and Foulis, A.K. (2010) Elastica staining for venous invasion results in superior prediction of cancer specific survival in colorectal cancer. Annals of Surgery, 252(6), pp. 989-997. (doi: 10.1097/SLA.0b013e3181f1c60d)

Roxburgh, C.S.D. , Wallace, A.M., Guthrie, G., Horgan, P.G. and McMillan, D.C. (2010) Comparison of the prognostic value of tumour and patient related factors in patients undergoing potentially curative surgery for colon cancer. Colorectal Disease, 12(10), pp. 987-994. (doi: 10.1111/j.1463-1318.2009.01961.x) (PMID:19555389)

Moug, S.J., Smith, D., Leen, E., Roxburgh, C. and Horgan, P.G. (2010) Evidence for a synchronous operative approach in the treatment of colorectal cancer with hepatic metastases: a case matched study. European Journal of Surgical Oncology, 36(4), pp. 365-370. (doi: 10.1016/j.ejso.2009.11.007)

Roxburgh, C.S.D. and McMillan, D.C. (2010) Comparison of the Prognostic Value of Inflammation-Based Pathologic and Biochemical Criteria in Patients Undergoing Potentially Curative Resection for Colorectal Cancer Reply. Annals of Surgery, 251(2), pp. 390-391. (doi: 10.1097/SLA.0b013e3181cb8b6f)

Leung, E.Y.L. , Roxburgh, C.S.D. , Leen, E. and Horgan, P. G. (2010) Combined resection and radiofrequency ablation for bilobar colorectal cancer liver metastases. Hepato-Gastroenterology, 57(97), pp. 41-46. (PMID:20422869)

Roxburgh, C. and McMillan, D.C. (2009) Re: Ishizuka et al., systemic inflammatory response predicts postoperative outcome in patients with liver metastases from colorectal cancer. Journal of Surgical Oncology, 100(7), p. 616. (doi: 10.1002/jso.21379)

Roxburgh, C.S., Salmond, J.M., Horgan, P.G., Oien, K.A. and McMillan, D.C. (2009) Tumour inflammatory infiltrate predicts survival following curative resection for node-negative colorectal cancer. European Journal of Cancer, 45(12), pp. 2138-2145. (doi: 10.1016/j.ejca.2009.04.011)

Roxburgh, C.S.D. , Crozier, J.E.M., Maxwell, F., Foulis, A.K., Brown, J., McKee, R.F., Anderson, J.H., Horgan, P.G. and McMillan, D.C. (2009) Comparison of tumour-based (Petersen Index) and inflammation-based (Glasgow Prognostic Score) scoring systems in patients undergoing curative resection for colon cancer. British Journal of Cancer, 100(5), pp. 701-706. (doi: 10.1038/sj.bjc.6604926)

Leung, E.Y.L. , Roxburgh, C.S.D., Leen, E. and Horgan, P.G. (2008) Combined resection and radiofrequency ablation for bilobar liver metastases. European Journal of Surgical Oncology, 34(10), p. 1168. (doi: 10.1016/j.ejso.2008.06.062)

Book Reviews

Roxburgh, C.S.D. and McMillan, D.C. (2010) Role of systemic inflammatory response in predicting survival in patients with primary operable cancer. Future Oncology, 6(1), pp. 149-163. (doi: 10.2217/FON.09.136)[Book Review]

Conference or Workshop Item

Dolan, R. , McSorley, S. T. , Park, J. H. , Roxburgh, C. S.D. , Horgan, P. G. and McMillan, D. C. (2018) The Prognostic Value of Systemic Inflammation in Patients Undergoing Surgery for Rectal Cancer: Comparison of Composite Ratios and Cumulative Scores. Gastrointestinal Cancers Symposium, San Francisco, CA, USA, 18-20 Jan 2018. (doi: 10.1200/JCO.2018.36.4_suppl.579)

Park, J.H. , McMillan, D.C. , Horgan, P.G. and Roxburgh, C.S.D. (2015) The Clinical Utility of a Tumour Microenvironment-based Histopathological Score in Patients with Primary Operable Colorectal Cancer. Journal of Clinical Oncology 33(3_suppl). 2015 Gastrointestinal Cancers Symposium, San Francisco, CA, USA, 15-17 Jan 2015. p. 664. (doi: 10.1200/jco.2015.33.3_suppl.664)