Professor Laura Machesky
- Affiliate (School of Cancer Sciences)
email:
Laura.Machesky@glasgow.ac.uk
Department of Biochemistryry, 80 Tennis Court Road, Sanger Building, Cambridge, CB2 1GA
Research interests
Link to Migration, Invasion and Metastasis website
Publications
2024
Nikolaou, Savvas, Juin, Amelie, Whitelaw, Jamie A., Paul, Nikki R., Fort, Loic, Nixon, Colin, Spence, Heather J., Bryson, Sheila and Machesky, Laura M. ORCID: https://orcid.org/0000-0002-7592-9856
(2024)
CYRI-B-mediated macropinocytosis drives metastasis via lysophosphatidic acid receptor uptake.
eLife, 13,
e83712.
(doi: 10.7554/elife.83712)
(PMID:38712822)
(PMCID:PMC11219039)
Kapitany, Valentin, Fatima, Areeba, Zickus, Vytautas, Whitelaw, Jamie, McGhee, Ewan, Insall, Robert ORCID: https://orcid.org/0000-0003-4898-040X, Machesky, Laura
ORCID: https://orcid.org/0000-0002-7592-9856 and Faccio, Daniele
ORCID: https://orcid.org/0000-0001-8397-334X
(2024)
Single-sample image-fusion upsampling of fluorescence lifetime images.
Science Advances, 10(21),
eadn0139.
(doi: 10.1126/sciadv.adn0139)
Juin, Amelie, Spence, Heather J. and Machesky, Laura M. ORCID: https://orcid.org/0000-0002-7592-9856
(2024)
Dichotomous role of the serine/threonine kinase MAP4K4 in pancreatic ductal adenocarcinoma onset and metastasis through control of AKT and ERK pathways.
Journal of Pathology, 262(4),
pp. 454-466.
(doi: 10.1002/path.6248)
(PMID:38229581)
2023
Morris, Hayley T. ORCID: https://orcid.org/0000-0002-9408-6671, Bamlet, William R., Razidlo, Gina L. and Machesky, Laura M.
ORCID: https://orcid.org/0000-0002-7592-9856
(2023)
FSCN1 and epithelial mesenchymal transformation transcription factor expression in human pancreatic intraepithelial neoplasia and ductal adenocarcinoma.
Pathology: Research and Practice, 251,
154836.
(doi: 10.1016/j.prp.2023.154836)
(PMID:37832352)
(PMCID:37832352)
Machesky, Laura M. ORCID: https://orcid.org/0000-0002-7592-9856
(2023)
CYRI proteins: controllers of actin dynamics in the cellular ‘eat vs walk’ decision.
Biochemical Society Transactions, 51(2),
pp. 579-585.
(doi: 10.1042/bst20221354)
(PMID:36892409)
Wilkinson, E. L. et al. (2023) Genetically engineered multicistronic allele of Pmel yielding highly specific CreERT2-mediated recombination in the melanocyte lineage. Pigment Cell and Melanoma Research, 36(1), pp. 71-77. (doi: 10.1111/pcmr.13076) (PMID:36412082)
2022
Papalazarou, Vasileios, Drew, James, Juin, Amelie, Spence, Heather J., Whitelaw, Jamie, Nixon, Colin, Salmeron-Sanchez, Manuel ORCID: https://orcid.org/0000-0002-8112-2100 and Machesky, Laura M.
ORCID: https://orcid.org/0000-0002-7592-9856
(2022)
Collagen VI expression is negatively mechanosensitive in pancreatic cancer cells and supports the metastatic niche.
Journal of Cell Science, 135(24),
jcs259978.
(doi: 10.1242/jcs.259978)
(PMID:36546396)
(PMCID:PMC9845737)
2021
Le, Anh Hoang, Yelland, Tamas, Paul, Nikki R., Fort, Loic, Nikolaou, Savvas, Ismail, Shehab ORCID: https://orcid.org/0000-0002-4150-1077 and Machesky, Laura M.
ORCID: https://orcid.org/0000-0002-7592-9856
(2021)
CYRI-A limits invasive migration through macropinosome formation and integrin uptake regulation.
Journal of Cell Biology, 220(9),
e202012114.
(doi: 10.1083/jcb.202012114)
(PMID:34165494)
(PMCID:PMC8236918)
Olson, Michael F. ORCID: https://orcid.org/0000-0003-3428-3507 and Machesky, Laura M.
ORCID: https://orcid.org/0000-0002-7592-9856
(2021)
MICAL2 fine-tunes Arp2/3 for actin branching.
Journal of Cell Biology, 220(8),
e202106176.
(doi: 10.1083/jcb.202106176)
(PMID:34264264)
Drew, James and Machesky, Laura M. ORCID: https://orcid.org/0000-0002-7592-9856
(2021)
The liver metastatic niche: modelling the extracellular matrix in metastasis.
Disease Models and Mechanisms, 14(4),
dmm048801.
(doi: 10.1242/dmm.048801)
(PMID:33973625)
(PMCID:PMC8077555)
Yelland, Tamas, Le, Anh Hoang, Nikolaou, Savvas, Insall, Robert ORCID: https://orcid.org/0000-0003-4898-040X, Machesky, Laura
ORCID: https://orcid.org/0000-0002-7592-9856 and Ismail, Shehab
ORCID: https://orcid.org/0000-0002-4150-1077
(2021)
Structural basis of CYRI-B direct competition with Scar/WAVE complex for Rac1.
Structure, 29(3),
226-237.e4.
(doi: 10.1016/j.str.2020.11.003)
(PMID:33217330)
(PMCID:PMC7955166)
Swaminathan, Karthic, Campbell, Andrew, Papalazarou, Vasileios, Jaber-Hijazi, Farah ORCID: https://orcid.org/0000-0001-6094-751X, Nixon, Colin, McGhee, Ewan, Strathdee, Douglas, Sansom, Owen J.
ORCID: https://orcid.org/0000-0001-9540-3010 and Machesky, Laura M.
ORCID: https://orcid.org/0000-0002-7592-9856
(2021)
The RAC1 target NCKAP1 plays a crucial role in the progression of Braf;Pten-driven melanoma in mice.
Journal of Investigative Dermatology, 141(3),
628-637.e15.
(doi: 10.1016/j.jid.2020.06.029)
(PMID:32777214)
Callenberg, C., Lyons, Ashley ORCID: https://orcid.org/0000-0002-6804-2106, den Brok, D., Fatima, Areeba, Turpin, Alex
ORCID: https://orcid.org/0000-0001-7877-782X, Zickus, Vytautas, Machesky, Laura
ORCID: https://orcid.org/0000-0002-7592-9856, Whitelaw, J., Faccio, Daniele
ORCID: https://orcid.org/0000-0001-8397-334X and Hullin, M.B.
(2021)
Super-resolution time-resolved imaging using computational sensor fusion.
Scientific Reports, 11,
1689.
(doi: 10.1038/s41598-021-81159-x)
(PMID:33462284)
(PMCID:PMC7813875)
Pickering, K.A. et al. (2021) A RAC-GEF network critical for early intestinal tumourigenesis. Nature Communications, 12, 56. (doi: 10.1038/s41467-020-20255-4) (PMID:33397922) (PMCID:PMC7782582)
2020
Zickus, V. et al. (2020) Fluorescence lifetime imaging with a megapixel SPAD camera and neural network lifetime estimation. Scientific Reports, 10, 20986. (doi: 10.1038/s41598-020-77737-0) (PMID:33268900) (PMCID:PMC7710711)
Papalazarou, Vasileios, Swaminathan, Karthic, Jaber-Hijazi, Farah ORCID: https://orcid.org/0000-0001-6094-751X, Spence, Heather, Lahmann, Ines, Nixon, Colin, Salmeron-Sanchez, Manuel
ORCID: https://orcid.org/0000-0002-8112-2100, Arnold, Hans-Henning, Rottner, Klemens and Machesky, Laura M.
ORCID: https://orcid.org/0000-0002-7592-9856
(2020)
The Arp2/3 complex is crucial for colonisation of the mouse skin by melanoblasts.
Development, 147(22),
dev194555.
(doi: 10.1242/dev.194555)
(PMID:33028610)
(PMCID:PMC7687863)
Tweedy, Luke, Thomason, Peter A., Paschke, Peggy I., Martin, Kirsty, Machesky, Laura M. ORCID: https://orcid.org/0000-0002-7592-9856, Zagnoni, Michele and Insall, Robert H.
ORCID: https://orcid.org/0000-0003-4898-040X
(2020)
Seeing around corners: cells solve mazes and respond at a distance using attractant breakdown.
Science, 369(6507),
eaay9792.
(doi: 10.1126/science.aay9792)
(PMID:32855311)
Singh, Shashi Prakash ORCID: https://orcid.org/0000-0002-6029-8115, Thomason, Peter A., Lilla, Sergio, Schaks, Matthias, Tang, Qing, Goode, Bruce L., Machesky, Laura M.
ORCID: https://orcid.org/0000-0002-7592-9856, Rottner, Klemens and Insall, Robert H.
ORCID: https://orcid.org/0000-0003-4898-040X
(2020)
Cell–substrate adhesion drives Scar/WAVE activation and phosphorylation by a Ste20-family kinase, which controls pseudopod lifetime.
PLoS Biology, 18(8),
e3000774.
(doi: 10.1371/journal.pbio.3000774)
(PMID:32745097)
(PMCID:PMC7425996)
McMenamin, Paul G., Shields, Graham T., Seyed-Razavi, Yashar, Kalirai, Helen, Insall, Robert H. ORCID: https://orcid.org/0000-0003-4898-040X, Machesky, Laura M.
ORCID: https://orcid.org/0000-0002-7592-9856 and Coupland, Sarah E.
(2020)
Melanoblasts populate the mouse choroid earlier in development than previously described.
Investigative Ophthalmology and Visual Science, 61(10),
33.
(doi: 10.1167/iovs.61.10.33)
(PMID:32797202)
(PMCID:PMC7441366)
Whitelaw, Jamie A., Swaminathan, Karthic, Kage, Frieda and Machesky, Laura M. ORCID: https://orcid.org/0000-0002-7592-9856
(2020)
The WAVE regulatory complex is required to balance protrusion and adhesion in migration.
Cells, 9(7),
1635.
(doi: 10.3390/cells9071635)
(PMID:32646006)
(PMCID:PMC7407199)
Nikolaou, Savvas and Machesky, Laura ORCID: https://orcid.org/0000-0002-7592-9856
(2020)
The stressful tumour environment drives plasticity of cell migration programmes, contributing to metastasis.
Journal of Pathology, 250(5),
pp. 612-623.
(doi: 10.1002/path.5395)
(PMID:32057095)
(PMCID:PMC7216910)
Papalazarou, Vasileios, Zhang, Tong, Paul, Nikki R., Juin, Amelie, Cantini, Marco ORCID: https://orcid.org/0000-0003-0326-1508, Maddocks, Oliver D.K.
ORCID: https://orcid.org/0000-0002-5551-9091, Salmeron-Sanchez, Manuel
ORCID: https://orcid.org/0000-0002-8112-2100 and Machesky, Laura
ORCID: https://orcid.org/0000-0002-7592-9856
(2020)
The creatine-phosphagen system is mechanoresponsive in pancreatic adenocarcinoma and fuels invasion and metastasis.
Nature Metabolism, 2(1),
pp. 62-80.
(doi: 10.1038/s42255-019-0159-z)
(PMID:32694686)
2019
Schurr, Y. et al. (2019) Platelet lamellipodium formation is not required for thrombus formation and stability. Blood, 134(25), pp. 2318-2329. (doi: 10.1182/blood.2019002105) (PMID:31697813)
Amato, Clelia, Thomason, Peter A., Davidson, Andrew J., Swaminathan, Karthic, Ismail, Shehab ORCID: https://orcid.org/0000-0002-4150-1077, Machesky, Laura M.
ORCID: https://orcid.org/0000-0002-7592-9856 and Insall, Robert H.
ORCID: https://orcid.org/0000-0003-4898-040X
(2019)
WASP restricts active Rac to maintain cells’ front-rear polarization.
Current Biology, 29(24),
pp. 4169-4182.
(doi: 10.1016/j.cub.2019.10.036)
(PMID:31786060)
(PMCID:PMC6926487)
Juin, A. et al. (2019) N-WASP control of LPAR1 trafficking establishes response to self-generated LPA gradients to promote pancreatic cancer cell metastasis. Developmental Cell, 51(4), 431-445.e7. (doi: 10.1016/j.devcel.2019.09.018) (PMID:31668663) (PMCID:PMC6863394)
Francis, S. et al. (2019) Structure-based design, synthesis and biological evaluation of a novel series of isoquinolone and pyrazolo[4,3-c]pyridine inhibitors of fascin 1 as potential anti-metastatic agents. Bioorganic and Medicinal Chemistry Letters, 29(8), pp. 1023-1029. (doi: 10.1016/j.bmcl.2019.01.035) (PMID:30773430) (PMCID:PMC6419574)
Nikolaou, Savvas and Machesky, Laura M. ORCID: https://orcid.org/0000-0002-7592-9856
(2019)
Invasion by force: The C. elegans anchor cell leads the way.
Developmental Cell, 48(3),
pp. 287-288.
(doi: 10.1016/j.devcel.2019.01.024)
Kugeratski, F. G. et al. (2019) Hypoxic cancer–associated fibroblasts increase NCBP2-AS2/HIAR to promote endothelial sprouting through enhanced VEGF signaling. Science Signaling, 12(567), eaan8247. (doi: 10.1126/scisignal.aan8247) (PMID:30723174) (PMCID:PMC6794160)
Machesky, Laura M. ORCID: https://orcid.org/0000-0002-7592-9856
(2019)
Rab11FIP proteins link endocytic recycling vesicles for cytoskeletal transport and tethering.
Bioscience Reports, 39(1),
BSR2018221.
(doi: 10.1042/bsr20182219)
(PMID:30622149)
(PMCID:PMC6356010)
Bachg, A. C. et al. (2019) Phenotypic analysis of Myo10 knockout (Myo10tm2/tm2) mice lacking full-length (motorized) but not brain-specific headless myosin X. Scientific Reports, 9, 597. (doi: 10.1038/s41598-018-37160-y) (PMID:30679680) (PMCID:PMC6345916)
Siebert, Sabina ORCID: https://orcid.org/0000-0001-9094-271X, Insall, Robert
ORCID: https://orcid.org/0000-0003-4898-040X and Machesky, Laura M.
ORCID: https://orcid.org/0000-0002-7592-9856
(2019)
More means less: managing overflow in science publishing.
In: Czarniawska, Barbara and Löfgren, Orvar (eds.)
Overwhelmed by Overflows? How People and Organizations Create and Manage Excess.
Lund University Press: Lund, pp. 130-150.
ISBN 9789198469813
(doi: 10.7765/9789198469813.00013)
2018
Papalazarou, Vasileios, Salmeron-Sanchez, Manuel ORCID: https://orcid.org/0000-0002-8112-2100 and Machesky, Laura M.
ORCID: https://orcid.org/0000-0002-7592-9856
(2018)
Tissue engineering the cancer microenvironment—challenges and opportunities.
Biophysical Reviews, 10(6),
pp. 1695-1711.
(doi: 10.1007/s12551-018-0466-8)
(PMID:30406572)
(PMCID:PMC6297082)
Fort, L. et al. (2018) Fam49/CYRI interacts with Rac1 and locally suppresses protrusions. Nature Cell Biology, 20(10), pp. 1159-1171. (doi: 10.1038/s41556-018-0198-9) (PMID:30250061) (PMCID:PMC6863750)
Morris, Hayley T. ORCID: https://orcid.org/0000-0002-9408-6671, Fort, Loic, Spence, Heather J., Patel, Rachana, Vincent, David F., Park, James H.
ORCID: https://orcid.org/0000-0002-6551-2037, Snapper, Scott B., Carey, Francis A., Sansom, Owen J.
ORCID: https://orcid.org/0000-0001-9540-3010 and Machesky, Laura M.
ORCID: https://orcid.org/0000-0002-7592-9856
(2018)
Loss of N-WASP drives early progression in an Apc model of intestinal tumourigenesis.
Journal of Pathology, 245(3),
pp. 337-348.
(doi: 10.1002/path.5086)
(PMID:29672847)
(PMCID:PMC6033012)
Laurent, Pascal, Petit, Valérie, Aktary, Zackie, Gallagher, Stuart, Tweedy, Luke, Machesky, Laura ORCID: https://orcid.org/0000-0002-7592-9856 and Larue, Lionel
(2018)
Simulation of melanoblast displacements reveals new features of developmental migration.
Development, 145(12),
dev160200.
(doi: 10.1242/dev.160200)
(PMID:29769218)
(PMCID:PMC6031402)
2017
Machesky, Laura ORCID: https://orcid.org/0000-0002-7592-9856 and Braga, Vania M.M.
(2017)
So far, yet so close: α-Catenin dimers help migrating cells get together.
Journal of Cell Biology, 216(11),
pp. 3437-3439.
(doi: 10.1083/jcb.201709056)
(PMID:29051263)
Giampazolias, E. et al. (2017) Mitochondrial permeabilization engages NF-κB-dependent anti-tumour activity under caspase deficiency. Nature Cell Biology, 19(9), pp. 1116-1129. (doi: 10.1038/ncb3596) (PMID:28846096) (PMCID:PMC5624512)
Reid, S. E. et al. (2017) Tumor matrix stiffness promotes metastatic cancer cell interaction with the endothelium. EMBO Journal, 36(16), pp. 2373-2389. (doi: 10.15252/embj.201694912) (PMID:28694244) (PMCID:PMC5556271)
Woodham, E. F. et al. (2017) Coordination by Cdc42 of actin, contractility, and adhesion for melanoblast movement in mouse skin. Current Biology, 27(5), pp. 624-637. (doi: 10.1016/j.cub.2017.01.033) (PMID:28238662) (PMCID:PMC5344686)
Thomas, Steven G., Poulter, Natalie S., Bem, Danai, Finney, Brenda, Machesky, Laura M. ORCID: https://orcid.org/0000-0002-7592-9856 and Watson, Stephen P.
(2017)
The actin binding proteins cortactin and HS1 are dispensable for platelet actin nodule and megakaryocyte podosome formation.
Platelets, 28(4),
pp. 372-379.
(doi: 10.1080/09537104.2016.1235688)
(PMID:27778524)
(PMCID:PMC5274539)
2016
Tyrrell, Benjamin J., Woodham, Emma F., Spence, Heather J., Strathdee, Douglas, Insall, Robert H. ORCID: https://orcid.org/0000-0003-4898-040X and Machesky, Laura M.
ORCID: https://orcid.org/0000-0002-7592-9856
(2016)
Loss of strumpellin in the melanocytic lineage impairs the WASH Complex but does not affect coat colour.
Pigment Cell and Melanoma Research, 29(5),
pp. 559-571.
(doi: 10.1111/pcmr.12506)
(PMID:27390154)
(PMCID:PMC5082549)
Sinclair, A. et al. (2016) CXCR2 and CXCL4 regulate survival and self-renewal of hematopoietic stem/progenitor cells. Blood, 128(3), pp. 371-383. (doi: 10.1182/blood-2015-08-661785) (PMID:27222476) (PMCID:PMC4991087)
García, Esther, Ragazzini, Chiara, Yu, Xinzi, Cuesta-García, Elena, Bernardino de la Serna, Jorge, Zech, Tobias, Sarrió, David, Machesky, Laura M. ORCID: https://orcid.org/0000-0002-7592-9856 and Antón, Inés M.
(2016)
WIP and WICH/WIRE co-ordinately control invadopodium formation and maturation in human breast cancer cell invasion.
Scientific Reports, 6,
23590.
(doi: 10.1038/srep23590)
(PMID:27009365)
(PMCID:PMC4806363)
2015
Ma, Yafeng and Machesky, Laura ORCID: https://orcid.org/0000-0002-7592-9856
(2015)
Fascin1 in carcinomas: Its regulation and prognostic value.
International Journal of Cancer, 137(11),
pp. 2534-2544.
(doi: 10.1002/ijc.29260)
(PMID:25302416)
Siebert, Sabina ORCID: https://orcid.org/0000-0001-9094-271X, Machesky, Laura M.
ORCID: https://orcid.org/0000-0002-7592-9856 and Insall, Robert H.
ORCID: https://orcid.org/0000-0003-4898-040X
(2015)
Overflow in science and its implications for trust.
eLife, 4,
e10825.
(doi: 10.7554/eLife.10825)
Giancotti, Filippo G., Haynes, Cole M., Machesky, Laura M. ORCID: https://orcid.org/0000-0002-7592-9856, Olson, Michael F.
ORCID: https://orcid.org/0000-0003-3428-3507 and Overholtzer, Michael
(2015)
Alan Hall 1952–2015.
Nature Cell Biology, 17(7),
pp. 839-840.
(doi: 10.1038/ncb3190)
(PMID:26005836)
Rainero, Elena, Howe, Jonathan D., Caswell, Patrick T., Jamieson, Nigel B. ORCID: https://orcid.org/0000-0002-9552-4725, Anderson, Kurt, Critchley, David R., Machesky, Laura
ORCID: https://orcid.org/0000-0002-7592-9856 and Norman, Jim C.
ORCID: https://orcid.org/0000-0002-0098-3014
(2015)
Ligand-occupied integrin internalization links nutrient signaling to invasive migration.
Cell Reports, 10(3),
pp. 398-413.
(doi: 10.1016/j.celrep.2014.12.037)
Vijayakumar, Vineetha, Monypenny, James, Chen, Xing Judy, Machesky, Laura M. ORCID: https://orcid.org/0000-0002-7592-9856, Lilla, Sergio, Thrasher, Adrian J., Anton, Ines M., Calle, Yolanda and Jones, Gareth E.
(2015)
Tyrosine phosphorylation of WIP releases bound WASP and impairs podosome assembly in macrophages.
Journal of Cell Science, 128(2),
pp. 251-265.
(doi: 10.1242/jcs.154880)
Lindsay, Colin R., Li, Ang, Faller, William, Ozanne, Bradford, Welch, Heidi, Machesky, Laura M. ORCID: https://orcid.org/0000-0002-7592-9856 and Sansom, Owen
ORCID: https://orcid.org/0000-0001-9540-3010
(2015)
A Rac1-independent role for P-Rex1 in melanoblasts.
Journal of Investigative Dermatology, 135(1),
pp. 314-318.
(doi: 10.1038/jid.2014.323)
Ma, Yafeng, Faller, William, Sansom, Owen ORCID: https://orcid.org/0000-0001-9540-3010, Brown, Ewan R., Doig, Tamasin N., Melton, David W. and Machesky, Laura
ORCID: https://orcid.org/0000-0002-7592-9856
(2015)
Fascin expression is increased in metastatic lesions but does not correlate with progression nor outcome in melanoma.
Melanoma Research, 25(2),
pp. 169-172.
(doi: 10.1097/CMR.0000000000000135)
(PMID:25535872)
Morris, H.T. ORCID: https://orcid.org/0000-0002-9408-6671 and Machesky, L.M.
ORCID: https://orcid.org/0000-0002-7592-9856
(2015)
Actin cytoskeletal control during epithelial to mesenchymal transition: focus on the pancreas and intestinal tract.
British Journal of Cancer, 112(4),
pp. 613-620.
(doi: 10.1038/bjc.2014.658)
(PMID:25611303)
(PMCID:PMC4333498)
2014
Muinonen-Martin, A. J. et al. (2014) Melanoma cells break down LPA to establish local gradients that drive chemotactic dispersal. PLoS Biology, 12(10), e1001966. (doi: 10.1371/journal.pbio.1001966) (PMID:25313567) (PMCID:PMC4196730)
García, Esther, Machesky, Laura M. ORCID: https://orcid.org/0000-0002-7592-9856, Jones, Gareth E. and Antón, Inés M.
(2014)
WIP is necessary for matrix invasion by breast cancer cells.
European Journal of Cell Biology, 93(10-12),
pp. 413-423.
(doi: 10.1016/j.ejcb.2014.07.008)
Woodham, Emma F. and Machesky, Laura M. ORCID: https://orcid.org/0000-0002-7592-9856
(2014)
Polarised cell migration: intrinsic and extrinsic drivers.
Current Opinion in Cell Biology, 30,
pp. 25-32.
(doi: 10.1016/j.ceb.2014.05.006)
Machesky, Laura ORCID: https://orcid.org/0000-0002-7592-9856 and Sedwick, Caitlin
(2014)
Laura Machesky: actin opens the way.
Journal of Cell Biology, 206(7),
pp. 816-817.
(doi: 10.1083/jcb.2067pi)
(PMID:25267291)
(PMCID:PMC4178962)
Li, A. et al. (2014) Fascin is regulated by slug, promotes progression of pancreatic cancer in mice, and is associated with patient outcomes. Gastroenterology, 146(5), 1386-1396.e17. (doi: 10.1053/j.gastro.2014.01.046) (PMID:24462734) (PMCID:PMC4000441)
Tyrrell, Benjamin J., Neilson, Matthew, Insall, Robert H. ORCID: https://orcid.org/0000-0003-4898-040X and Machesky, Laura M.
ORCID: https://orcid.org/0000-0002-7592-9856
(2014)
Predicting cell shapes in melanomas.
Pigment Cell and Melanoma Research, 27(1),
pp. 5-6.
(doi: 10.1111/pcmr.12176)
(PMID:24118871)
2013
Schachtner, Hannah, Li, Ang, Stevenson, David, Calaminus, Simon D.J., Thomas, Steven G., Watson, Steve P., Sixt, Michael, Wedlich-Soldner, Roland, Strathdee, Douglas and Machesky, Laura M. ORCID: https://orcid.org/0000-0002-7592-9856
(2013)
Tissue inducible Lifeact expression allows visualization of actin dynamics in vivo and ex vivo.
European Journal of Cell Biology, 91(11-12),
pp. 923-929.
(doi: 10.1016/j.ejcb.2012.04.002)
Futó, K., Bódis, E., Machesky, L.M. ORCID: https://orcid.org/0000-0002-7592-9856, Nyitrai, M. and Visegrády, B.
(2013)
Membrane binding properties of IRSp53-missing in metastasis domain (IMD) protein.
Biochimica et Biophysica Acta: Molecular and Cell Biology of Lipids, 1831(11),
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A major role for Scar/WAVE-1 downstream of GPVI in platelets.
Journal of Thrombosis and Haemostasis, 5(3),
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N-WASP involvement in dorsal ruffle formation in mouse embryonic fibroblasts.
Molecular Biology of the Cell, 18(2),
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Bathe, Frederike S., Rommelaere, Heidi and Machesky, Laura M. ORCID: https://orcid.org/0000-0002-7592-9856
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Phenotypes of myopathy-related actin mutants in differentiated C2C12 myotubes.
BMC Cell Biology, 8,
2.
(doi: 10.1186/1471-2121-8-2)
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The role of Arabidopsis SCAR genes in ARP2-ARP3-dependent cell morphogenesis.
Development, 134(5),
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MIM: a multifunctional scaffold protein.
Journal of Molecular Medicine, 85,
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(doi: 10.1007/s00109-007-0207-0)
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2006
Baldassarre, Massimiliano, Ayala, Inmaculada, Beznoussenko, Galina, Giacchetti, Giada, Machesky, Laura M. ORCID: https://orcid.org/0000-0002-7592-9856, Luini, Alberto and Buccione, Roberto
(2006)
Actin dynamics at sites of extracellular matrix degradation.
European journal of cell biology, 85(12),
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Bar domain proteins: a role in tubulation, scission and actin assembly in clathrin-mediated endocytosis.
Trends in cell biology, 16(10),
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(2006)
Scar/WAVE Proteins in Cell Spreading and Membrane Dynamics.
67th Annual Meeting of the Society of General Physiologists, Woods Hole, MA, USA, 6-10 September 2006.
(doi: 10.1085/jgp.128.1.1a)
ten Klooster, Jean Paul, Evers, Eva E., Janssen, Lennert, Machesky, Laura M. ORCID: https://orcid.org/0000-0002-7592-9856, Michiels, Frits, Hordijk, Peter and Collard, John G.
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Interaction between Tiam1 and the Arp2/3 complex links activation of Rac to actin polymerization.
Biochemical Journal, 397(1),
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(2006)
von Willebrand factor mediates platelet spreading through glycoprotein Ib and αIIbβ3 in the presence of botrocetin and ristocetin, respectively.
Journal of Thrombosis and Haemostasis, 4(6),
pp. 1367-1378.
(doi: 10.1111/j.1538-7836.2006.01966.x)
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Ardern, H., Sandilands, E., Machesky, L.M. ORCID: https://orcid.org/0000-0002-7592-9856, Timpson, P., Frame, M.C. and Brunton, V.G.
(2006)
Src-dependent phosphorylation of Scar1 promotes its association with the Arp2/3 complex.
Cell Motility and the Cytoskeleton, 63(1),
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(doi: 10.1002/cm.20101)
2005
Deeks, Michael J., Cvrcková, Fatima, Machesky, Laura M. ORCID: https://orcid.org/0000-0002-7592-9856, Mikitová, Veronika, Ketelaar, Tijs, Zársky, Viktor, Davies, Brendan and Hussey, Patrick J.
(2005)
Arabidopsis group le formins localize to specific cell membrane domains, interact with actin-binding proteins and cause defects in cell expansion upon aberrant expression.
New Phytologist, 168(3),
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(doi: 10.1111/j.1469-8137.2005.01582.x)
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Bompard, Guillaume, Sharp, Stewart J., Freiss, Gilles and Machesky, Laura M. ORCID: https://orcid.org/0000-0002-7592-9856
(2005)
Involvement of Rac in actin cytoskeleton rearrangements induced by MIM-B.
Journal of Cell Science, 118(22),
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(2005)
Actin Nucleators in Plants.
Society for Experimental Biology Annual Main Meeting, Barcelona, Spain, 11-15 July 2005.
(doi: 10.1016/j.cbpb.2005.05.026)
Machesky, L.M. ORCID: https://orcid.org/0000-0002-7592-9856, Millard, T.H., Bompard, G., Sharp, S.J., Woodings, J.A. and Futterer, K.
(2005)
Regulation of the Actin Cytoskeleton by IRSp53 and MIM Proteins.
IUBMB 50th Anniversary Symposium: Protein Structureand Function, Budapest, Hungary, 2–7 July 2005.
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(2005)
Actin filament assembly: the search for a barbed end.
In: Ridley, Anne, Peckham, Michelle and Clark, Peter (eds.)
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Wiley, pp. 135-147.
ISBN 9780470094099
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Millard, Thomas H., Bompard, Guillaume, Heung, Man Yeung, Dafforn, Timothy R., Scott, David J., Machesky, Laura M. ORCID: https://orcid.org/0000-0002-7592-9856 and Fütterer, Klaus
(2005)
Structural basis of filopodia formation induced by the IRSp53/MIM homology domain of human IRSp53.
EMBO Journal, 24(2),
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(doi: 10.1038/sj.emboj.7600535)
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Stovold, Craig F., Millard, Thomas H. and Machesky, Laura M. ORCID: https://orcid.org/0000-0002-7592-9856
(2005)
Inclusion of Scar/WAVE3 in a similar complex to Scar/WAVE1 and 2.
BMC Cell Biology, 6,
11.
(doi: 10.1186/1471-2121-6-11)
(PMID:15752430)
(PMCID:PMC555569)
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Legg, John A. and Machesky, Laura M. ORCID: https://orcid.org/0000-0002-7592-9856
(2004)
MRL proteins: leading Ena/VASP to Ras GTPases.
Nature Cell Biology, 6(11),
pp. 1015-1017.
(doi: 10.1038/ncb1104-1015)
(PMID:15516992)
Clarkson, Emilie, Costa, Celine F. and Machesky, Laura M. ORCID: https://orcid.org/0000-0002-7592-9856
(2004)
Congenital myopathies: diseases of the actin cytoskeleton.
Journal of Pathology, 204(4),
pp. 407-417.
(doi: 10.1002/path.1648)
(PMID:15495263)
Unsworth, Kate E., Way, Michael, McNiven, Mark, Machesky, Laura ORCID: https://orcid.org/0000-0002-7592-9856 and Holden, David W.
(2004)
Analysis of the mechanisms of Salmonella-induced actin assembly during invasion of host cells and intracellular replication.
Cellular microbiology, 6(11),
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(doi: 10.1111/j.1462-5822.2004.00417.x)
(PMID:15469433)
McCarty, O. J. T., Zhao, Y., Andrew, N., Machesky, L. M. ORCID: https://orcid.org/0000-0002-7592-9856, Staunton, D., Frampton, J. and Watson, S. P.
(2004)
Evaluation of the role of platelet integrins in fibronectin-dependent spreading and adhesion.
Journal of Thrombosis and Haemostasis, 2(10),
pp. 1823-1833.
(doi: 10.1111/j.1538-7836.2004.00925.x)
(PMID:15456495)
Costa, Céline F., Rommelaere, Heidi, Waterschoot, Davy, Sethi, Kamaljiit K., Nowak, Kristen J., Laing, Nigel G., Ampe, Christophe and Machesky, Laura M. ORCID: https://orcid.org/0000-0002-7592-9856
(2004)
Myopathy mutations in α-skeletal-muscle actin cause a range of molecular defects.
Journal of Cell Science, 117(15),
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(doi: 10.1242/jcs.01172)
(PMID:15226407)
Insall, Robert H. ORCID: https://orcid.org/0000-0003-4898-040X and Machesky, Laura M.
ORCID: https://orcid.org/0000-0002-7592-9856
(2004)
Regulation of WASP: PIP2 pipped By Toca-1?
Cell, 118(2),
pp. 140-141.
(doi: 10.1016/j.cell.2004.07.005)
(PMID:15260983)
Millard, Thomas H., Sharp, Stewart J. and Machesky, Laura M. ORCID: https://orcid.org/0000-0002-7592-9856
(2004)
Signalling to actin assembly via the WASP (Wiskott-Aldrich syndrome protein)-family proteins and the Arp2/3 complex.
Biochemical Journal, 380(1),
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(doi: 10.1042/bj20040176)
(PMID:15040784)
(PMCID:PMC1224166)
Vartiainen, Maria K. and Machesky, Laura M. ORCID: https://orcid.org/0000-0002-7592-9856
(2004)
The WASP–Arp2/3 pathway: genetic insights.
Current Opinion in Cell Biology, 16(2),
pp. 174-181.
(doi: 10.1016/j.ceb.2004.02.004)
(PMID:15196561)
Millard, T.H., Bompard, G., Sharp, S.J. and Machesky, L.M. ORCID: https://orcid.org/0000-0002-7592-9856
(2004)
Regulation of actin dynamics by the IRSp53 and MIM family of proteins.
Molecular Biology of the Cell, 15,
387A-387A.
2003
Singh, Saurabh, Powell, David W., Rane, Madhavi J., Millard, Tom H., Trent, John O., Pierce, William M., Klein, Jon B., Machesky, Laura M. ORCID: https://orcid.org/0000-0002-7592-9856 and McLeish, Kenneth R.
(2003)
Identification of the p16-Arc subunit of the Arp 2/3 complex as a substrate of MAPK-activated protein kinase 2 by proteomic analysis.
Journal of Biological Chemistry, 278(38),
pp. 36410-36417.
(doi: 10.1074/jbc.M306428200)
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Launay, Sophie, Giannı̀, Maurizio, Diomede, Luisa, Machesky, Laura M. ORCID: https://orcid.org/0000-0002-7592-9856, Enoug, Jocelyne and Papp, Béla
(2003)
Enhancement of ATRA-induced cell differentiation by inhibition of calcium accumulation into the endoplasmic reticulum: cross-talk between RARα and calcium-dependent signaling.
Blood, 101(8),
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(doi: 10.1182/blood-2002-09-2730)
(PMID:12515718)
Launay, Sophie, Brown, Geoffrey and Machesky, Laura M. ORCID: https://orcid.org/0000-0002-7592-9856
(2003)
Expression of WASP and Scar1/WAVE1 actin-associated proteins is differentially modulated during differentiation of HL-60 cells.
Cell Motility and the Cytoskeleton, 54(4),
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(doi: 10.1002/cm.10101)
(PMID:12601690)
Woodings, Jacquelyn A., Sharp, Stewart J. and Machesky, Laura M. ORCID: https://orcid.org/0000-0002-7592-9856
(2003)
MIM-B, a putative metastasis suppressor protein, binds to actin and to protein tyrosine phosphatase delta.
Biochemical Journal, 371(2),
pp. 463-471.
(doi: 10.1042/bj20021962)
(PMID:12570871)
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Oda, A. et al. (2003) CrkL directs ASAP1 to peripheral focal adhesions. Journal of Biological Chemistry, 278(8), pp. 6456-6460. (doi: 10.1074/jbc.M210817200) (PMID:12522101)
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ORCID: https://orcid.org/0000-0003-4898-040X and Nash, Gerard B.
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Linked regulation of motility and integrin function in activated migrating neutrophils revealed by interference in remodelling of the cytoskeleton.
Cell Motility and the Cytoskeleton, 54(2),
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(doi: 10.1002/cm.10091)
(PMID:12529859)
Machesky, Laura M. ORCID: https://orcid.org/0000-0002-7592-9856 and Bornens, Michel
(2003)
Cell structure and dynamics.
Current Opinion in Cell Biology, 15(1),
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(doi: 10.1016/S0955-0674(02)00016-9)
(PMID:12517697)
Magdalena, Juana, Millard, Thomas H., Etienne-Manneville, Sandrine, Launay, Sophie, Warwick, Helen K. and Machesky, Laura M. ORCID: https://orcid.org/0000-0002-7592-9856
(2003)
Involvement of the Arp2/3 complex and Scar2 in Golgi polarity in scratch wound models.
Molecular Biology of the Cell, 14(2),
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(doi: 10.1091/mbc.e02-06-0345)
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Magdalena, Juana, Millard, Thomas H. and Machesky, Laura M. ORCID: https://orcid.org/0000-0002-7592-9856
(2003)
Microtubule involvement in NIH 3T3 Golgi and MTOC polarity establishment.
Journal of Cell Science, 116(4),
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(PMID:12538774)
Millard, Thomas H., Behrendt, Barbara, Launay, Sophie, Fütterer, Klaus and Machesky, Laura M. ORCID: https://orcid.org/0000-0002-7592-9856
(2003)
Identification and characterisation of a novel human isoform of Arp2/3 complex subunit p16-ARC/ARPC5.
Cell Motility and the Cytoskeleton, 54(1),
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(doi: 10.1002/cm.10087)
(PMID:12451597)
2002
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(2002)
Actin filament formation, reorganization and migration are impaired in hepatic stellate cells under influence of trichostatin A, a histone deacetylase inhibitor.
Journal of Hepatology, 37(6),
pp. 788-796.
(doi: 10.1016/S0168-8278(02)00275-1)
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Olazabal, Isabel M., Caron, Emmanuelle, May, Robin C., Schilling, Kerstin, Knecht, David A. and Machesky, Laura M. ORCID: https://orcid.org/0000-0002-7592-9856
(2002)
Rho-kinase and myosin-II control phagocytic cup formation during CR, but not FcγR, phagocytosis.
Current Biology, 12(16),
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(doi: 10.1016/S0960-9822(02)01069-2)
(PMID:12194823)
Machesky, Laura M. ORCID: https://orcid.org/0000-0002-7592-9856
(2002)
Sharks' teeth and dunes.
Nature, 417,
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Machesky, Laura ORCID: https://orcid.org/0000-0002-7592-9856 and Burd, Gary
(2002)
Cytoskeleton signalling: 7 November 2001.
Biochemist, 24(1),
p. 32.
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Insall, Robert ORCID: https://orcid.org/0000-0003-4898-040X, Müller-Taubenberger, Annette, Machesky, Laura
ORCID: https://orcid.org/0000-0002-7592-9856, Köhler, Jana, Simmeth, Evelyn, Atkinson, Simon J., Weber, Igor and Gerisch, Günther
(2001)
Dynamics of the Dictyostelium Arp2/3 complex in endocytosis, cytokinesis, and chemotaxis.
Cell Motility and the Cytoskeleton, 50(3),
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(doi: 10.1002/cm.10005)
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Elliott, David A., Coleman, Daniel J., Lane, Michael A., May, Robin C., Machesky, Laura M. ORCID: https://orcid.org/0000-0002-7592-9856 and Clark, Douglas P.
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Cryptosporidium parvum infection requires host cell actin polymerization.
Infection and Immunity, 69(9),
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(doi: 10.1128/iai.69.9.5940-5942.2001)
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May, Robin C. and Machesky, Laura M. ORCID: https://orcid.org/0000-0002-7592-9856
(2001)
Plagiarism and pathogenesis: common themes in actin remodeling.
Developmental Cell, 1(3),
pp. 317-318.
(doi: 10.1016/S1534-5807(01)00051-X)
(PMID:11702942)
Olazabal, Isabel M. and Machesky, Laura M. ORCID: https://orcid.org/0000-0002-7592-9856
(2001)
Abp1p and cortactin, new “hand-holds” for actin.
Journal of Cell Biology, 154(4),
pp. 679-682.
(doi: 10.1083/jcb.200105061)
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Burns, Siobhan, Thrasher, Adrian J., Blundell, Michael P., Machesky, Laura ORCID: https://orcid.org/0000-0002-7592-9856 and Jones, Gareth E.
(2001)
Configuration of human dendritic cell cytoskeleton by Rho GTPases, the WAS protein, and differentiation.
Blood, 98(4),
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(doi: 10.1182/blood.v98.4.1142)
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Machesky, Laura M. ORCID: https://orcid.org/0000-0002-7592-9856, Insall, Robert H.
ORCID: https://orcid.org/0000-0003-4898-040X and Volkman, Loy E.
(2001)
WASP homology sequences in baculoviruses.
Trends in Cell Biology, 11(7),
pp. 286-287.
(doi: 10.1016/S0962-8924(01)02009-8)
(PMID:11434350)
Bailly, Maryse, Ichetovkin, Ilia, Grant, Wayne, Zebda, Noureddine, Machesky, Laura M. ORCID: https://orcid.org/0000-0002-7592-9856, Segall, Jeffrey E. and Condeelis, John
(2001)
The F-actin side binding activity of the Arp2/3 complex is essential for actin nucleation and lamellipod extension.
Current Biology, 11(8),
pp. 620-625.
(doi: 10.1016/S0960-9822(01)00152-X)
(PMID:11369208)
Millard, Tom H. and Machesky, Laura M. ORCID: https://orcid.org/0000-0002-7592-9856
(2001)
The Wiskott-Aldrich syndrome protein (WASP) family.
Trends in Biochemical Sciences, 26(3),
pp. 189-199.
(doi: 10.1016/S0968-0004(01)01788-1)
(PMID:11246027)
May, R.C. and Machesky, L.M. ORCID: https://orcid.org/0000-0002-7592-9856
(2001)
Phagocytosis and the actin cytoskeleton.
Journal of Cell Science, 114(6),
pp. 1061-1077.
(PMID:11228151)
Stinchcombe, Jane C., Barral, Duarte C., Mules, Emilie H., Booth, Sarah, Hume, Alistair N., Machesky, Laura M. ORCID: https://orcid.org/0000-0002-7592-9856, Seabra, Miguel C. and Griffiths, Gillian M.
(2001)
Rab27a is required for regulated secretion in cytotoxic T lymphocytes.
Journal of Cell Biology, 152(4),
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(doi: 10.1083/jcb.152.4.825)
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Timpson, P., Carragher, N. O., Machesky, L. ORCID: https://orcid.org/0000-0002-7592-9856 and Frame, M. C.
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Association of scar with the SRC tyrosine kinase: consequences for scar regulation.
British Journal of Cancer, 85,
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(doi: 10.1054/bjoc.2001.1917)
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Cytoskeleton.
Encyclopedia of Life Sciences,
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Machesky, Laura M. ORCID: https://orcid.org/0000-0002-7592-9856 and May, Robin C.
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Arps: actin-related proteins.
In: dos Remedios, G. and Thomas, D.D. (eds.)
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Springer.
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Rombouts, K., Knittel, T., Wielant, A., Piscaglia, F., Machesky, L. ORCID: https://orcid.org/0000-0002-7592-9856, Hellemans, K., Gelman, I., Ramadori, G. and Feerts, A.
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Effect of trichostatin A, a histone deacetylase inhibitor, on proteins of the actin cytoskeleton.
Cells of the Hepatic Sinusoid, 8,
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Pistor, S., Grobe, L., Sechi, A.S., Domann, E., Gerstel, B., Machesky, L.M. ORCID: https://orcid.org/0000-0002-7592-9856, Chakraborty, T. and Wehland, J.
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Mutations of arginine residues within the 146-KKRRK-150 motif of the ActA protein of Listeria monocytogenes abolish intracellular motility by interfering with the recruitment of the Arp2/3 complex.
Journal of Cell Science, 113(18),
pp. 3277-3287.
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Machesky, Laura M. ORCID: https://orcid.org/0000-0002-7592-9856
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Putting on the brakes: a negative regulatory function for Ena/VASP proteins in cell migration.
Cell, 101(7),
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Nature Cell Biology, 2(4),
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Rozelle, A.L., Machesky, L.M. ORCID: https://orcid.org/0000-0002-7592-9856, Yamamoto, M., Driessens, M.H.E., Insall, R.H.
ORCID: https://orcid.org/0000-0003-4898-040X, Roth, M.G., Luby-Phelps, K., Marriott, G., Hall, A. and Yin, H.L.
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Current Biology, 10(6),
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The tails of two myosins.
Journal of Cell Biology, 148(2),
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Cell dynamics: a new look at the cytoskeleton.
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Molecular Biology of the Cell, 11,
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Methods in Enzymology, 325,
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Cell motility: Bare bones of the cytoskeleton.
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May, Robin C., Hall, Margaret E., Higgs, Henry N., Pollard, Thomas D., Chakraborty, Trinad, Wehland, Juergen, Machesky, Laura M. ORCID: https://orcid.org/0000-0002-7592-9856 and Sechi, Antonio S.
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Rocket-based motility: a universal mechanism?
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Scar1 and the related Wiskott–Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complex.
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Visualization and molecular analysis of actin assembly in living cells.
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The small GTPases Rho and Rac are required for the establishment of cadherin-dependent cell-cell contacts.
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The actin-binding protein profilin binds to PIP2 and inhibits its hydrolysis by phospholipase C.
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Structure-function studies of the actin filament system of Acanthamoeba.
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Kang, Z.C., Machesky, Laura ORCID: https://orcid.org/0000-0002-7592-9856, Eick, H.A. and Eyring, L.
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CYRI-A limits invasive migration through macropinosome formation and integrin uptake regulation.
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(doi: 10.1126/science.2157283)
(PMID:2157283)
Kang, Z.C., Machesky, Laura ORCID: https://orcid.org/0000-0002-7592-9856, Eick, H.A. and Eyring, L.
(1988)
The solvolytic disproportionation of mixed-valence compounds: III. Pb3O4.
Journal of Solid State Chemistry, 75(1),
pp. 73-89.
(doi: 10.1016/0022-4596(88)90304-0)
Book Sections
Siebert, Sabina ORCID: https://orcid.org/0000-0001-9094-271X, Insall, Robert
ORCID: https://orcid.org/0000-0003-4898-040X and Machesky, Laura M.
ORCID: https://orcid.org/0000-0002-7592-9856
(2019)
More means less: managing overflow in science publishing.
In: Czarniawska, Barbara and Löfgren, Orvar (eds.)
Overwhelmed by Overflows? How People and Organizations Create and Manage Excess.
Lund University Press: Lund, pp. 130-150.
ISBN 9789198469813
(doi: 10.7765/9789198469813.00013)
Stovold, Craig F., Sharp, Stewart J. and Machesky, Laura ORCID: https://orcid.org/0000-0002-7592-9856
(2005)
Actin filament assembly: the search for a barbed end.
In: Ridley, Anne, Peckham, Michelle and Clark, Peter (eds.)
Cell Motility: From Molecules to Organisms.
Wiley, pp. 135-147.
ISBN 9780470094099
Machesky, Laura M. ORCID: https://orcid.org/0000-0002-7592-9856 and May, Robin C.
(2001)
Arps: actin-related proteins.
In: dos Remedios, G. and Thomas, D.D. (eds.)
Molecular Interactions of Actin.
Springer.
ISBN 9783540671107
(doi: 10.1007/978-3-540-46560-7_15)
Pollard, Thomas D., Machesky, Laura ORCID: https://orcid.org/0000-0002-7592-9856 and Goldschmidt-Clermont, Pascal
(1991)
Interaction of profilins with membrane lipids.
In: Mooseker, Mark S. and Morrow, Jon S. (eds.)
Ordering the Membrane-Cytoskeleton Trilayer.
Series: Current Topics in Membranes (38).
Academic Press: San Diego, California ; London, pp. 217-225.
ISBN 9780121533380
(doi: 10.1016/S0070-2161(08)60790-X)
Pollard, Thomas D., Magnus, Karen A., Doberstein, Stephen, Goldschmidt-Clermont, Pascal, Kaiser, Donald A., Machesky, Laura ORCID: https://orcid.org/0000-0002-7592-9856, Maciver, Sutherland, Rimm, David L. and Wachsstock, Daniel
(1989)
Structure-function studies of the actin filament system of Acanthamoeba.
In: Aebi, Ueli and Engel, Jürgen (eds.)
Cytoskeletal and Extracellular Proteins: Structure, Interactions and Assembly The 2nd International EBSA Symposium.
Series: Springer series in biophysics (3).
Springer: Berlin, Heidelberg, pp. 271-279.
ISBN 9783642739279
(doi: 10.1007/978-3-642-73925-5_50)
Conference or Workshop Item
Davidson, A.J., Veltman, D.M., Machesky, L.M. ORCID: https://orcid.org/0000-0002-7592-9856 and Insall, R.H.
(2012)
The Interplay Between SCAR (WAVE) and WASP in Actin-Based Motility.
2012 American Society for Cell Biology Annual Meeting, San Francisco, CA, USA, 15-19 Dec 2012.
p. 1823.
(doi: 10.1091/mbc.e12-10-0757)
Monteiro, P., Hertzog, M., Rossé, C., Desnos, C., Zech, T., Formstecher, E., Darchen, F., Machesky, L. ORCID: https://orcid.org/0000-0002-7592-9856, Gautreau, A. and Chavrier, P.
(2012)
Co-ordinated Functions of WASH and Exocyst Complex Underlie the Biogenesis of Invadopodia in Metastatic Breast Tumor Cells.
2012 American Society for Cell Biology Annual Meeting, San Francisco, CA, USA, 15-19 Dec 2012.
p. 2077.
(doi: 10.1091/mbc.e12-10-0757)
Zech, T. et al. (2012) N-WASP Coordinates the Delivery and F-actin Mediated Reversible Capture of MT1-MMP at Invasive Pseudopods to Drive Breast Cancer Cell Invasion. 2012 American Society for Cell Biology Annual Meeting, San Francisco, CA, USA, 15-19 Dec 2012. p. 2076. (doi: 10.1091/mbc.e12-10-0757)
Doyle, B., Tan, E.H., Timpson, P., Machesky, L.M. ORCID: https://orcid.org/0000-0002-7592-9856, Ridgway, R.R., Jeffery, R.R., Poulsom, R., Morton, J.P. and Sansom, O.J.
(2012)
The Tumor Suppressor ARF Can Promote Invasion in the Absence of p53 Activity.
United States and Canadian Academy of Pathology 101st Annual Meeting, Vancouver, BC, Canada, 17-23 Mar 2012.
461A.
(doi: 10.1038/modpathol.2012.27)
Futó, Kinga, Machesky, Laura M. ORCID: https://orcid.org/0000-0002-7592-9856 and Visegrády, Balázs
(2011)
The Role of the I-BAR Domain in the Filopodia Formation.
8th EBSA European Biophysics Congress, Budapest, Hungary, 23-27 Aug 2011.
S197.
(doi: 10.1007/s00249-011-0734-z)
Machesky, Laura M. ORCID: https://orcid.org/0000-0002-7592-9856, Legg, John A., McCarty, Owen J., Calaminus, Simon D.J. and Watson, Steve P.
(2006)
Scar/WAVE Proteins in Cell Spreading and Membrane Dynamics.
67th Annual Meeting of the Society of General Physiologists, Woods Hole, MA, USA, 6-10 September 2006.
(doi: 10.1085/jgp.128.1.1a)
Deeks, M.J., Kaloriti, D., Machesky, L.M. ORCID: https://orcid.org/0000-0002-7592-9856, Malho, Rui, Davies, B. and Hussey, P.J.
(2005)
Actin Nucleators in Plants.
Society for Experimental Biology Annual Main Meeting, Barcelona, Spain, 11-15 July 2005.
(doi: 10.1016/j.cbpb.2005.05.026)
Machesky, L.M. ORCID: https://orcid.org/0000-0002-7592-9856, Millard, T.H., Bompard, G., Sharp, S.J., Woodings, J.A. and Futterer, K.
(2005)
Regulation of the Actin Cytoskeleton by IRSp53 and MIM Proteins.
IUBMB 50th Anniversary Symposium: Protein Structureand Function, Budapest, Hungary, 2–7 July 2005.
Owen, J. et al. (2005) Rac1 is Essential for Platelet Lamellipodia and Aggregate Stability Under Flow. BSCR Spring Meeting 2005
Grants
Grants and Awards listed are those received whilst working with the University of Glasgow.
- Harnessing the physics of light to reveal mechanisms of multicellular shape and movement
Engineering and Physical Sciences Research Council
2019 - 2022
- Metabolic drivers of pancreatic cancer cell migration and metastasis
Medical Research Council
2018 - 2020
- Investigating the role of N-WASP in the development and metastasis of colorectal cancer (SCP3 Fellowship 2012)
Medical Research Council
2012 - 2017
Research datasets
2022
Nikolaou, S., Juin, A., Whitelaw, J., Paul, N., Fort, L., Nixon, C., Spence, H., Bryson, S. and Machesky, L. (2022) CYRI-B mediated macropinocytosis drives metastasis via lysophosphatidic acid receptor uptake. [Data Collection]
2020
Zickus, V., Wu, M.-L., Morimoto, K., Kapitany, V., Fatima, A., Turpin, A. , Insall, R. , Whitelaw, J., Machesky, L. , Bruschini, C., Faccio, D. and Charbon, E. (2020) Fluorescence lifetime imaging with a megapixel SPAD camera and neural network lifetime estimation. [Data Collection]
Tweedy, L., Thomason, P., Paschke, P., Martin, K., Machesky, L. , Zagnoni, M. and Insall, R. (2020) Seeing around corners: cells solve mazes and respond at a distance using attractant breakdown. [Data Collection]