Data & Reagents
The CVR produces data and datasets that are deposited in public repositories (e.g. GenBank, Dryad and the Electron Microscopy and Protein Data Banks [EMDB and PDB]) at the time of publication. Data can also be accessed through the University of Glasgow’s Enlighten Research Data Repository. In addition, the CVR produces unique resources for accessing the data that it generates. The Centre also plays pivotal roles in clinical studies that enable access to data and samples through application processes. Finally, the CVR offers bespoke reagents and tools for research purposes to support the virology community.
Openly Accessible Data
We follow the University of Glasgow's approach to Reseach Data Management.
Hundreds of interferon stimulated genes (ISGs) are upregulated through IFN signalling, which is one of the first steps in creating an antiviral state in cells. This plethora of ISGs is collectively referred to as the interferome. The ISG database catalogues the interferomes of ten different species, each derived from cells in an antiviral state after stimulation with type-I IFN.
GLUE (Genes Linked by Underlying Evolution) has been developed as a data-centric bioinformatics environment for curating virus sequence data. The platform focuses on the variation, evolution and sequence interpretation for viral sequence data. The CVR has developed specific GLUE resources for several viruses including SARS-COV-2, HCV, HEV and BTV. The data schema and bioinformatics functionality can also be customised and extended to other viruses or virus families.
Virus and Protein Structure Data
The CVR incorporates groups engaged in determining the structures of both viruses and viral proteins. Studies include structural analysis of feline calicivirus (FCV), which causes respiratory disease in cats and is a member of the calicivirus family. We also examine viruses such as respiratory syncytial virus (RSV) and influenza A, which are responsible for severe respiratory infections in the human population.
Scottish Centre for Macromolecular Imaging
The CVR also houses the Scottish Centre for Macromolecular Imaging, which is a national cryo-EM facility that offers advanced instrumentation and expertise for producing high resolution data for structural studies.
Restricted Access Data
The CVR is heavily engaged in several clinical studies. Access to data and samples from two studies, ISARIC-4C and HCV Research UK, requires a formal process for approval. For accessing data from other clinical studies, please contact Emma Thomson, Antonia Ho, Ruth Jarrett and Janet Scott.
In partnership with the MRC Protein Phosphorylation and Ubiquitylation Unit at the University of Dundee, the CVR has created a Coronavirus Toolkit incorporating expression plasmids, proteins and polyclonal antibodies for research studies on SARS-COV-2 and related coronaviruses. The Centre also has produced monoclonal antibodies for studies on feline immunodeficiency virus (FIV). We are in the process of creating a CVR Repository of reagents for various studies in virus research. Please contact Sarah McDonald for details.