Local and systemic functions of the adult intestine in health and disease

Research in my laboratory is devoted to understanding how intestinal stem cells (ISCs) adapt and respond to changes in their micro and macro-environment, how the intestine senses and controls whole-body homeostasis and how intestinal dysfunction can lead to broader organismal instability. We use the fruit fly Drosophila melanogaster as a primary research model system due to its unparalleled genetic power and amenability for multi-organ in vivo studies combined with experiments in mammalian systems.

Selected publications

Research publications, last five years (*Co-First; 1Corresponding).

- Perochon, J., Aughey, G.N., Southall, T.D., and Cordero, J.B1. Dynamic adult tracheal plasticity drives stem cell adaptation to changes in intestinal homeostasis. Nat Cell Biol (in press)

- Naszai, M., Yu, Y., Fernandez, A.R., Sandilands, E., Johansson, J., Norman, J.C., Sansom, O.J., Bryant, D., and Cordero, J.B1. RAL GTPases mediate EGFR/MAPK signalling-driven intestinal stem cell proliferation and tumourigenesis upstream of RAS activation. eLife (in revision)

-Parvy JP1, Yu Y, Dostalova A, Kondo S, Kurjan A, Bulet P, Lemaitre B, Vidal M, Cordero JB1. The antimicrobial peptide Defensin cooperates with Tumour Necrosis Factor to drive tumour cell death in Drosophila. eLife. 2019 Jul 30;8. pii: e45061. doi: 10.7554/eLife.45061. Recommended by the Faculty of 1000.

-Johansson J*, Naszai M*, Hodder M, Pickering K, Miller BW, Ridgway RA, Yu Y, Peschard P, Brachmann B, Campbell AD, Cordero, JB1, Sansom, OJ1. RAL GTPases drive intestinal stem cell function and regeneration through internalization of WNT signalosomes. Cell Stem Cell. Apr 4;24(4):592-607.e7. doi: 10.1016/j.stem.2019.02.002. Commentary in Cell Stem Cell 2019 Apr 4;24(4):499-500. doi: 10.1016/j.stem.2019.03.008. 

-Scopelliti A1*, Bauer C*, Yu Y, Zhang T, Krüspig B, Murphy DJ, Vidal M, Maddocks OK, Cordero JB1. A neuronal relay mediates a nutrient responsive gut/fat body   axis regulating energy homeostasis in adult Drosophila. Cell Metab. Oct 15. pii: S1550-4131(18)30629-6. doi: 10.1016/j.cmet.2018.09.021. Recommended by the Faculty of 1000. 

-Tian A, Benchabane H, Wang Z, Zimmerman C, Xin N, Perochon J, Kalna G, Sansom OJ, Cheng C, Cordero JB, Ahmed Y. Intestinal stem cell overproliferation resulting from inactivation of the APC tumor suppressor requires the transcription cofactors Earthbound and Erect wing. PLoS Genet. 2017 Jul 14;13(7):e1006870. doi: 10.1371/journal.pgen.1006870.

 -Scopelliti A1, Bauer C, Cordero J1 and Vidal M. Bursicon-α subunit modulates dLGR2 activity in the adult Drosophila melanogaster midgut independently to Bursicon-β. Cell Cycle. 2016 Jun 17;15(12):1538-44.

Invited Review and pre-view articles (last five years):

- Bellec K, Cordero JB. The Peroxisome: A New Player in Intestinal Epithelial Repair. Dev Cell. 2020 Apr 20;53(2):131-132. doi: 10.1016/j.devcel.2020.03.023.

- Parvy JP, Hodgson JA, Cordero JB. Drosophila as a Model System to Study Nonautonomous Mechanisms Affecting Tumour Growth and Cell Death. Biomed Res Int. 2018 Mar 13;2018:7152962.

- Perochon J, Carroll LR, Cordero JB. Wnt Signalling in Intestinal Stem Cells: Lessons from Mice and Flies. Genes (Basel). 2018 Mar 2;9(3). pii: E138. doi: 10.3390/genes9030138.

- Nászai M, Cordero JB. Intestinal Stem Cells: Got Calcium? Curr Biol. Feb 8;26(3):R117-9. Invited Dispatch article on Deng H et al. Signal integration by Ca2+ regulates intestinal stem-cell activity. Nature. 2015 Dec 2. doi: 10.1038/nature16170.

- Nászai M, Carroll LR, Cordero JB. Intestinal stem cell proliferation and epithelial homeostasis in the adult Drosophila midgut. Insect Biochem Mol Biol. 2015 May 27. pii: S0965-1748(15)30003-5.