The Spatial Biology of Head and Neck Cancer Inequalities
Supervisors:
Prof Gareth Inman, School of Cancer Sciences
Prof Crispin Miller, School of Cancer Sciences
Prof David Conway, School of Medicine, Dentistry & Nursing
Summary:
Head and Neck Cancers (HNC) are rising at an alarming rate in Scotland, with oropharyngeal squamous cell carcinoma (OPSCC) now the 4th most common cancer in Scottish men. Despite global advances in cancer care, survival rates for HNC remain poor—especially in the West of Scotland—where socioeconomic inequalities and HPV status significantly impact outcomes. This pioneering research initiative brings together experts in epidemiology, molecular and cellular biology, and computational science to uncover why some patients respond poorly to treatment and how we can change that.
Using a unique cohort of over 1,000 OPSCC patients, we will integrate clinical data with cutting-edge molecular profiling and spatial analysis to map the biological drivers of treatment failure. By combining transcriptomics, proteomics, AI-driven bioinformatics, and experimental cell biology techniques, we aim to identify new therapeutic targets and develop more effective, personalised treatments. This project not only seeks to revolutionise care for HNC patients but also to address deep-rooted health inequalities. Our multidisciplinary training program will equip the student with the skills to lead future breakthroughs in cancer research.