Dr Alasdair Fraser
- Honorary Senior Lecturer (School of Infection & Immunity)
email:
Alasdair.Fraser@glasgow.ac.uk
Chemokine Research Group, Level 3 GBRC, 120 University Place, Glasgow G12 8TA
Publications
2024
Carvell, Tom, Burgoyne, Paul, Milne, Laura, Campbell, John D.M., Fraser, Alasdair R. and Bridle, Helen (2024) Human leucocytes processed by fast-rate inertial microfluidics retain conventional functional characteristics. Journal of the Royal Society: Interface, 21(212), 20230572. (doi: 10.1098/rsif.2023.0572) (PMID:38442860) (PMCID:PMC10914517)
2018
Hansell, C. A.H. et al. (2018) The atypical chemokine receptor Ackr2 constrains NK cell migratory activity and promotes metastasis. Journal of Immunology, 201(8), pp. 2510-2519. (doi: 10.4049/jimmunol.1800131) (PMID:30158126) (PMCID:PMC6176105)
Wilson, Ruairi A.M., Evans, T.R. Jeffry ORCID: https://orcid.org/0000-0002-4175-914X, Fraser, Alasdair R. and Nibbs, Robert J.B.
ORCID: https://orcid.org/0000-0002-8150-0044
(2018)
Immune checkpoint inhibitors: new strategies to checkmate cancer.
Clinical and Experimental Immunology, 191(2),
pp. 133-148.
(doi: 10.1111/cei.13081)
(PMID:29139554)
2016
Elmesmari, Aziza, Fraser, Alasdair R., Wood, Claire, Gilchrist, Derek, Vaughan, Diane ORCID: https://orcid.org/0000-0002-4530-2278, Stewart, Lynn, McSharry, Charles, McInnes, Iain B.
ORCID: https://orcid.org/0000-0002-6462-4280 and Kurowska-Stolarska, Mariola
ORCID: https://orcid.org/0000-0003-2124-7777
(2016)
MicroRNA-155 regulates monocyte chemokine and chemokine receptor expression in Rheumatoid Arthritis.
Rheumatology, 55(11),
pp. 2056-2065.
(doi: 10.1093/rheumatology/kew272)
(PMID:27411480)
(PMCID:PMC5088623)
2015
Le Brocq, Michelle, Fraser, Alasdair R., Graham, Gerard J. ORCID: https://orcid.org/0000-0002-7801-204X and Campbell, John D.M.
(2015)
CCL19-sorted mature dendritic cells have enhanced lymph node migratory capacity and function.
Journal of Inflammation, 12(S1),
P2.
(doi: 10.1186/1476-9255-12-S1-P2)
(PMCID:PMC4416168)
2014
Elmesmari, Aziza, Gilchrist, Derek S., Fraser, Alasdair R., Graham, Gerard J. ORCID: https://orcid.org/0000-0002-7801-204X, Brewer, James
ORCID: https://orcid.org/0000-0001-7933-0915, Kurowska-Stolarska, Mariola
ORCID: https://orcid.org/0000-0003-2124-7777 and McInnes, Iain B.
ORCID: https://orcid.org/0000-0002-6462-4280
(2014)
Mir-155 Expression Correlates with Clinical Disease Activity and has Effector Function in Rheumatoid Arthritis.
2014 ACR/ARHP Annual Meeting, Boston, MA, 14-19 Nov 2014.
(Unpublished)
Le Brocq, Michelle L., Fraser, Alasdair R., Cotton, Graham, Woznica, Kerry, McCulloch, Clare V., Hewit, Kay D., McKimmie, Clive S., Nibbs, Robert J.B. ORCID: https://orcid.org/0000-0002-8150-0044, Campbell, John D.M. and Graham, Gerard J.
ORCID: https://orcid.org/0000-0002-7801-204X
(2014)
Chemokines as novel and versatile reagents for flow cytometry and cell sorting.
Journal of Immunology, 192(12),
pp. 6120-6130.
(doi: 10.4049/jimmunol.1303371)
(PMID:24850722)
Elmesmari, Aziza, Gilchrist, Derek S., Fraser, Alasdair R., Vaughan, Diane ORCID: https://orcid.org/0000-0002-4530-2278, Graham, Gerard J.
ORCID: https://orcid.org/0000-0002-7801-204X, Brewer, James
ORCID: https://orcid.org/0000-0001-7933-0915, Kurowska-Stolarska, Mariola
ORCID: https://orcid.org/0000-0003-2124-7777 and McInnes, Iain B.
ORCID: https://orcid.org/0000-0002-6462-4280
(2014)
MicroRNA-155 Regulates Chemokines and Chemokine Receptors in Rheumatoid Arthritis Monocytes.
Libya Higher Education Forum, London, UK, 5-6 June 2014.
(Unpublished)
Hewit, Kay D., Fraser, Alasdair, Nibbs, Robert J.B. ORCID: https://orcid.org/0000-0002-8150-0044 and Graham, Gerard J.
ORCID: https://orcid.org/0000-0002-7801-204X
(2014)
The N-terminal region of the atypical chemokine receptor ACKR2 is a key determinant of ligand binding.
Journal of Biological Chemistry, 289(18),
pp. 12330-12342.
(doi: 10.1074/jbc.M113.534545)
2013
Oleinika, K., Nibbs, R.J. ORCID: https://orcid.org/0000-0002-8150-0044, Graham, G.J.
ORCID: https://orcid.org/0000-0002-7801-204X and Fraser, A.R.
(2013)
Suppression, subversion and escape: the role of regulatory T cells in cancer progression.
Clinical and Experimental Immunology, 171(1),
pp. 36-45.
(doi: 10.1111/j.1365-2249.2012.04657.x)
2012
Akbar, Moeed, Fraser, Alasdair R., Graham, Gerard J. ORCID: https://orcid.org/0000-0002-7801-204X, Brewer, James M.
ORCID: https://orcid.org/0000-0001-7933-0915 and Grant, M. Helen
(2012)
Acute inflammatory response to cobalt chromium orthopaedic wear debris in a rodent air-pouch model.
Journal of the Royal Society: Interface, 9(74),
pp. 2109-2119.
(doi: 10.1098/rsif.2012.0006)
Elmesmari, A., Gilchrist, D., Fraser, A., Brewer, J. ORCID: https://orcid.org/0000-0001-7933-0915, McInnes, I.
ORCID: https://orcid.org/0000-0002-6462-4280 and Kurowska-Stolarska, M.
ORCID: https://orcid.org/0000-0003-2124-7777
(2012)
The role of miR-155 in monocyte migration in Rheumatoid arthritis.
In: European Congress of Immunology, Glasgow, UK, 5-8 Sept 2012,
pp. 588-589.
(doi: 10.1111/imm.12002)
Elmesmari, Aziza, Gilchrist, Derek S., Fraser, Alasdair D., Vaughan, Diane ORCID: https://orcid.org/0000-0002-4530-2278, McQueenie, Ross, Graham, Gerard
ORCID: https://orcid.org/0000-0002-7801-204X, Brewer, James
ORCID: https://orcid.org/0000-0001-7933-0915, McInnes, Iain B.
ORCID: https://orcid.org/0000-0002-6462-4280 and Kurowska-Stolarska, Mariola
ORCID: https://orcid.org/0000-0003-2124-7777
(2012)
Microrna-155 regulates chemokines and chemokine receptors in Rheumatoid Arthritis monocyte.
In: American College of Rheumatology & Association of Rheumatology Health Professionals, Annual Scientific Meeting, Washington DC, USA, 9-14 Nov 2012,
S384.
(doi: 10.1002/art.37735)
Marr, L.A., Gilham, D.E., Campbell, J.D.M. and Fraser, A.R. (2012) Immunology in the clinic review series; focus on cancer: double trouble for tumours: bi-functional and redirected T cells as effective cancer immunotherapies. Clinical and Experimental Immunology, 167(2), pp. 216-225. (doi: 10.1111/j.1365-2249.2011.04517.x)
2011
Kurowska-Stolarska, M. et al. (2011) MicroRNA-155 as a proinflammatory regulator in clinical and experimental arthritis. Proceedings of the National Academy of Sciences of the United States of America, 108(27), pp. 11193-11198. (doi: 10.1073/pnas.1019536108) (PMID:21690378)
Codullo, V. et al. (2011) An investigation of the inflammatory cytokine and chemokine network in systemic sclerosis. Annals of the Rheumatic Diseases, 70(6), pp. 1115-1121. (doi: 10.1136/ard.2010.137349) (PMID:21285114)
2010
Fraser, A.R., Perry, M.E., Crilly, A., Reilly, J.H., Hueber, A.J. and McInnes, I.B. ORCID: https://orcid.org/0000-0002-6462-4280
(2010)
Lipoma arborescens co-existing with psoriatic arthritis releases tumour necrosis factor alpha and matrix metalloproteinase.
Annals of the Rheumatic Diseases, 69(4),
pp. 776-777.
(doi: 10.1136/ard.2008.106047)
(PMID:20237127)
2009
McKimmie, C. S. et al. (2009) A TLR2 ligand suppresses inflammation by modulation of chemokine receptors and redirection of leukocyte migration. Blood, 113(18), pp. 4224-4231. (doi: 10.1182/blood-2008-08-174698) (PMID:19202130)
2008
McKimmie, C. S. et al. (2008) Hemopoietic cell expression of the chemokine decoy receptor D6 is dynamic and regulated by GATA1. Journal of Immunology, 181(5), pp. 3353-3363. (doi: 10.4049/jimmunol.181.11.8170-a) (PMID:19039854)
Xu, D. et al. (2008) IL-33 exacerbates antigen-induced arthritis by activating mast cells. Proceedings of the National Academy of Sciences of the United States of America, 105(31), pp. 10913-10918. (doi: 10.1073/pnas.0801898105) (PMID:18667700) (PMCID:PMC2491487)
Grespan, Renata, Fukada, Sandra Y., Lemos, Henrique P., Vieira, Silvio M., Napimoga, Marcelo H., Teixeira, Mauro M., Fraser, Alasdair R., Liew, Foo Y., McInnes, Iain B. ORCID: https://orcid.org/0000-0002-6462-4280 and Cunha, Fernando Q.
(2008)
CXCR2‐specific chemokines mediate leukotriene B4–dependent recruitment of neutrophils to inflamed joints in mice with antigen‐induced arthritis.
Arthritis and Rheumatism, 58(7),
pp. 2030-2040.
(doi: 10.1002/art.23597)
(PMID:18576322)
Fraser, A, Fraser, A, Hughes, R, McCarthy, A, Tilling, K, Davies, D, Rumley, A, Lowe, GD, Smith, GD and Ben Shlomo, Y (2008) Early life growth and hemostatic factors. American Journal of Epidemiology, 168(2), pp. 179-187.
Fraser, A., Fraser, A., Sattar, N.A., Ebrahim, S. and Lawlor, D.A. (2008) Is serum-glutamylatransferase a biomarker of xenobiotics which are conjugated by glutathione? Response. Arteriosclerosis, Thrombosis, and Vascular Biology, 28(4), E29-E29.
2007
Verri, Waldiceu A., Cunha, Thiago M., Ferreira, Sérgio H., Wei, Xiaoqing, Leung, Bernard P., Fraser, Alasdair, McInnes, Iain B. ORCID: https://orcid.org/0000-0002-6462-4280, Liew, Foo Y. and Cunha, Fernando Q.
(2007)
IL-15 mediates antigen-induced neutrophil migration by triggering IL-18 production.
European Journal of Immunology, 37(12),
pp. 3373-3380.
(doi: 10.1002/eji.200737488)
(PMID:17979156)
2005
Jongbloed, Sarah L., Lebre, M. Cristina, Fraser, Alasdair R., Gracie, J. Alastair, Sturrock, Roger D., Tak, Paul P. and McInnes, Iain B. ORCID: https://orcid.org/0000-0002-6462-4280
(2005)
Enumeration and phenotypical analysis of distinct dendritic cell subsets in psoriatic arthritis and rheumatoid arthritis.
Arthritis Research and Therapy, 8(1),
R15.
(doi: 10.1186/ar1864)
(PMID:16507115)
(PMCID:PMC1526567)
Articles
Carvell, Tom, Burgoyne, Paul, Milne, Laura, Campbell, John D.M., Fraser, Alasdair R. and Bridle, Helen (2024) Human leucocytes processed by fast-rate inertial microfluidics retain conventional functional characteristics. Journal of the Royal Society: Interface, 21(212), 20230572. (doi: 10.1098/rsif.2023.0572) (PMID:38442860) (PMCID:PMC10914517)
Hansell, C. A.H. et al. (2018) The atypical chemokine receptor Ackr2 constrains NK cell migratory activity and promotes metastasis. Journal of Immunology, 201(8), pp. 2510-2519. (doi: 10.4049/jimmunol.1800131) (PMID:30158126) (PMCID:PMC6176105)
Wilson, Ruairi A.M., Evans, T.R. Jeffry ORCID: https://orcid.org/0000-0002-4175-914X, Fraser, Alasdair R. and Nibbs, Robert J.B.
ORCID: https://orcid.org/0000-0002-8150-0044
(2018)
Immune checkpoint inhibitors: new strategies to checkmate cancer.
Clinical and Experimental Immunology, 191(2),
pp. 133-148.
(doi: 10.1111/cei.13081)
(PMID:29139554)
Elmesmari, Aziza, Fraser, Alasdair R., Wood, Claire, Gilchrist, Derek, Vaughan, Diane ORCID: https://orcid.org/0000-0002-4530-2278, Stewart, Lynn, McSharry, Charles, McInnes, Iain B.
ORCID: https://orcid.org/0000-0002-6462-4280 and Kurowska-Stolarska, Mariola
ORCID: https://orcid.org/0000-0003-2124-7777
(2016)
MicroRNA-155 regulates monocyte chemokine and chemokine receptor expression in Rheumatoid Arthritis.
Rheumatology, 55(11),
pp. 2056-2065.
(doi: 10.1093/rheumatology/kew272)
(PMID:27411480)
(PMCID:PMC5088623)
Le Brocq, Michelle, Fraser, Alasdair R., Graham, Gerard J. ORCID: https://orcid.org/0000-0002-7801-204X and Campbell, John D.M.
(2015)
CCL19-sorted mature dendritic cells have enhanced lymph node migratory capacity and function.
Journal of Inflammation, 12(S1),
P2.
(doi: 10.1186/1476-9255-12-S1-P2)
(PMCID:PMC4416168)
Le Brocq, Michelle L., Fraser, Alasdair R., Cotton, Graham, Woznica, Kerry, McCulloch, Clare V., Hewit, Kay D., McKimmie, Clive S., Nibbs, Robert J.B. ORCID: https://orcid.org/0000-0002-8150-0044, Campbell, John D.M. and Graham, Gerard J.
ORCID: https://orcid.org/0000-0002-7801-204X
(2014)
Chemokines as novel and versatile reagents for flow cytometry and cell sorting.
Journal of Immunology, 192(12),
pp. 6120-6130.
(doi: 10.4049/jimmunol.1303371)
(PMID:24850722)
Hewit, Kay D., Fraser, Alasdair, Nibbs, Robert J.B. ORCID: https://orcid.org/0000-0002-8150-0044 and Graham, Gerard J.
ORCID: https://orcid.org/0000-0002-7801-204X
(2014)
The N-terminal region of the atypical chemokine receptor ACKR2 is a key determinant of ligand binding.
Journal of Biological Chemistry, 289(18),
pp. 12330-12342.
(doi: 10.1074/jbc.M113.534545)
Oleinika, K., Nibbs, R.J. ORCID: https://orcid.org/0000-0002-8150-0044, Graham, G.J.
ORCID: https://orcid.org/0000-0002-7801-204X and Fraser, A.R.
(2013)
Suppression, subversion and escape: the role of regulatory T cells in cancer progression.
Clinical and Experimental Immunology, 171(1),
pp. 36-45.
(doi: 10.1111/j.1365-2249.2012.04657.x)
Akbar, Moeed, Fraser, Alasdair R., Graham, Gerard J. ORCID: https://orcid.org/0000-0002-7801-204X, Brewer, James M.
ORCID: https://orcid.org/0000-0001-7933-0915 and Grant, M. Helen
(2012)
Acute inflammatory response to cobalt chromium orthopaedic wear debris in a rodent air-pouch model.
Journal of the Royal Society: Interface, 9(74),
pp. 2109-2119.
(doi: 10.1098/rsif.2012.0006)
Marr, L.A., Gilham, D.E., Campbell, J.D.M. and Fraser, A.R. (2012) Immunology in the clinic review series; focus on cancer: double trouble for tumours: bi-functional and redirected T cells as effective cancer immunotherapies. Clinical and Experimental Immunology, 167(2), pp. 216-225. (doi: 10.1111/j.1365-2249.2011.04517.x)
Kurowska-Stolarska, M. et al. (2011) MicroRNA-155 as a proinflammatory regulator in clinical and experimental arthritis. Proceedings of the National Academy of Sciences of the United States of America, 108(27), pp. 11193-11198. (doi: 10.1073/pnas.1019536108) (PMID:21690378)
Codullo, V. et al. (2011) An investigation of the inflammatory cytokine and chemokine network in systemic sclerosis. Annals of the Rheumatic Diseases, 70(6), pp. 1115-1121. (doi: 10.1136/ard.2010.137349) (PMID:21285114)
Fraser, A.R., Perry, M.E., Crilly, A., Reilly, J.H., Hueber, A.J. and McInnes, I.B. ORCID: https://orcid.org/0000-0002-6462-4280
(2010)
Lipoma arborescens co-existing with psoriatic arthritis releases tumour necrosis factor alpha and matrix metalloproteinase.
Annals of the Rheumatic Diseases, 69(4),
pp. 776-777.
(doi: 10.1136/ard.2008.106047)
(PMID:20237127)
McKimmie, C. S. et al. (2009) A TLR2 ligand suppresses inflammation by modulation of chemokine receptors and redirection of leukocyte migration. Blood, 113(18), pp. 4224-4231. (doi: 10.1182/blood-2008-08-174698) (PMID:19202130)
McKimmie, C. S. et al. (2008) Hemopoietic cell expression of the chemokine decoy receptor D6 is dynamic and regulated by GATA1. Journal of Immunology, 181(5), pp. 3353-3363. (doi: 10.4049/jimmunol.181.11.8170-a) (PMID:19039854)
Xu, D. et al. (2008) IL-33 exacerbates antigen-induced arthritis by activating mast cells. Proceedings of the National Academy of Sciences of the United States of America, 105(31), pp. 10913-10918. (doi: 10.1073/pnas.0801898105) (PMID:18667700) (PMCID:PMC2491487)
Grespan, Renata, Fukada, Sandra Y., Lemos, Henrique P., Vieira, Silvio M., Napimoga, Marcelo H., Teixeira, Mauro M., Fraser, Alasdair R., Liew, Foo Y., McInnes, Iain B. ORCID: https://orcid.org/0000-0002-6462-4280 and Cunha, Fernando Q.
(2008)
CXCR2‐specific chemokines mediate leukotriene B4–dependent recruitment of neutrophils to inflamed joints in mice with antigen‐induced arthritis.
Arthritis and Rheumatism, 58(7),
pp. 2030-2040.
(doi: 10.1002/art.23597)
(PMID:18576322)
Fraser, A, Fraser, A, Hughes, R, McCarthy, A, Tilling, K, Davies, D, Rumley, A, Lowe, GD, Smith, GD and Ben Shlomo, Y (2008) Early life growth and hemostatic factors. American Journal of Epidemiology, 168(2), pp. 179-187.
Fraser, A., Fraser, A., Sattar, N.A., Ebrahim, S. and Lawlor, D.A. (2008) Is serum-glutamylatransferase a biomarker of xenobiotics which are conjugated by glutathione? Response. Arteriosclerosis, Thrombosis, and Vascular Biology, 28(4), E29-E29.
Verri, Waldiceu A., Cunha, Thiago M., Ferreira, Sérgio H., Wei, Xiaoqing, Leung, Bernard P., Fraser, Alasdair, McInnes, Iain B. ORCID: https://orcid.org/0000-0002-6462-4280, Liew, Foo Y. and Cunha, Fernando Q.
(2007)
IL-15 mediates antigen-induced neutrophil migration by triggering IL-18 production.
European Journal of Immunology, 37(12),
pp. 3373-3380.
(doi: 10.1002/eji.200737488)
(PMID:17979156)
Jongbloed, Sarah L., Lebre, M. Cristina, Fraser, Alasdair R., Gracie, J. Alastair, Sturrock, Roger D., Tak, Paul P. and McInnes, Iain B. ORCID: https://orcid.org/0000-0002-6462-4280
(2005)
Enumeration and phenotypical analysis of distinct dendritic cell subsets in psoriatic arthritis and rheumatoid arthritis.
Arthritis Research and Therapy, 8(1),
R15.
(doi: 10.1186/ar1864)
(PMID:16507115)
(PMCID:PMC1526567)
Conference or Workshop Item
Elmesmari, Aziza, Gilchrist, Derek S., Fraser, Alasdair R., Graham, Gerard J. ORCID: https://orcid.org/0000-0002-7801-204X, Brewer, James
ORCID: https://orcid.org/0000-0001-7933-0915, Kurowska-Stolarska, Mariola
ORCID: https://orcid.org/0000-0003-2124-7777 and McInnes, Iain B.
ORCID: https://orcid.org/0000-0002-6462-4280
(2014)
Mir-155 Expression Correlates with Clinical Disease Activity and has Effector Function in Rheumatoid Arthritis.
2014 ACR/ARHP Annual Meeting, Boston, MA, 14-19 Nov 2014.
(Unpublished)
Elmesmari, Aziza, Gilchrist, Derek S., Fraser, Alasdair R., Vaughan, Diane ORCID: https://orcid.org/0000-0002-4530-2278, Graham, Gerard J.
ORCID: https://orcid.org/0000-0002-7801-204X, Brewer, James
ORCID: https://orcid.org/0000-0001-7933-0915, Kurowska-Stolarska, Mariola
ORCID: https://orcid.org/0000-0003-2124-7777 and McInnes, Iain B.
ORCID: https://orcid.org/0000-0002-6462-4280
(2014)
MicroRNA-155 Regulates Chemokines and Chemokine Receptors in Rheumatoid Arthritis Monocytes.
Libya Higher Education Forum, London, UK, 5-6 June 2014.
(Unpublished)
Conference Proceedings
Elmesmari, A., Gilchrist, D., Fraser, A., Brewer, J. ORCID: https://orcid.org/0000-0001-7933-0915, McInnes, I.
ORCID: https://orcid.org/0000-0002-6462-4280 and Kurowska-Stolarska, M.
ORCID: https://orcid.org/0000-0003-2124-7777
(2012)
The role of miR-155 in monocyte migration in Rheumatoid arthritis.
In: European Congress of Immunology, Glasgow, UK, 5-8 Sept 2012,
pp. 588-589.
(doi: 10.1111/imm.12002)
Elmesmari, Aziza, Gilchrist, Derek S., Fraser, Alasdair D., Vaughan, Diane ORCID: https://orcid.org/0000-0002-4530-2278, McQueenie, Ross, Graham, Gerard
ORCID: https://orcid.org/0000-0002-7801-204X, Brewer, James
ORCID: https://orcid.org/0000-0001-7933-0915, McInnes, Iain B.
ORCID: https://orcid.org/0000-0002-6462-4280 and Kurowska-Stolarska, Mariola
ORCID: https://orcid.org/0000-0003-2124-7777
(2012)
Microrna-155 regulates chemokines and chemokine receptors in Rheumatoid Arthritis monocyte.
In: American College of Rheumatology & Association of Rheumatology Health Professionals, Annual Scientific Meeting, Washington DC, USA, 9-14 Nov 2012,
S384.
(doi: 10.1002/art.37735)