Dr Alan Bilsland
- Honorary Lecturer, Affiliate (School of Cancer Sciences)
email:
Alan.Bilsland@glasgow.ac.uk
314 Level 3,, Wolfson Wohl Cancer Res. Centre,, G61 1qh
Publications
2023
Seitz, Judith, Bilsland, Alan ORCID: https://orcid.org/0000-0003-0957-3908, Puget, Chloé, Baasner, Ian, Klopfleisch, Robert and Stein, Torsten
(2023)
SFRP1 expression is inversely associated with metastasis formation in canine mammary tumours.
Journal of Mammary Gland Biology and Neoplasia, 28(1),
p. 15.
(doi: 10.1007/s10911-023-09543-z)
(PMID:37402051)
2021
Ibrahim, Ayman, Bilsland, Alan ORCID: https://orcid.org/0000-0003-0957-3908, Rickelt, Steffen, Morris, Joanna
ORCID: https://orcid.org/0000-0001-5975-2475 and Stein, Torsten
ORCID: https://orcid.org/0000-0002-9946-1549
(2021)
A matrisome RNA signature from early-pregnancy mouse mammary fibroblasts predicts distant metastasis-free breast cancer survival in humans.
Breast Cancer Research, 23,
90.
(doi: 10.1186/s13058-021-01470-3)
(PMID:34565423)
(PMCID:PMC8474794)
2019
Bilsland, Alan E. ORCID: https://orcid.org/0000-0003-0957-3908, Liu, Yu, Turnbull, Andrew, Sumpton, David, Stevenson, Katrina, Cairney, Claire J., Boyd, Susan M., Roffey, Jon, Jenkinson, David and Keith, W. Nicol
ORCID: https://orcid.org/0000-0001-7862-3580
(2019)
A novel pyrazolopyrimidine ligand of human PGK1 and stress sensor DJ1 modulates the shelterin complex and telomere length regulation.
Neoplasia, 21(9),
pp. 893-907.
(doi: 10.1016/j.neo.2019.07.008)
(PMID:31401411)
(PMCID:PMC6700475)
2018
Bilsland, Alan ORCID: https://orcid.org/0000-0003-0957-3908, Kelly, Caroline
ORCID: https://orcid.org/0000-0002-5330-7888, Roccisana, Jennifer, Paul, James
ORCID: https://orcid.org/0000-0001-7367-5816, Jones, Robert
ORCID: https://orcid.org/0000-0002-2904-6980, Edwards, Joanne
ORCID: https://orcid.org/0000-0002-7192-6906, Roseweir, Antonia
ORCID: https://orcid.org/0000-0001-6158-1564, Stein, Torsten
ORCID: https://orcid.org/0000-0002-9946-1549 and West, Katherine
ORCID: https://orcid.org/0000-0002-5994-8969
(2018)
An Exploratory Study on the Use of Game-based Learning Using Microsoft Kinect to Teach Oncology Phase I Clinical Trial Designs.
2018 NCRI Cancer Conference, Glasgow, UK, 04-06 Nov 2018.
(doi: 10.1038/s41416-018-0299-z)
2017
Cairney, C. J. et al. (2017) A 'synthetic-sickness' screen for senescence re-engagement targets in mutant cancer backgrounds. PLoS Genetics, 13(8), e1006942. (doi: 10.1371/journal.pgen.1006942) (PMID:28806777) (PMCID:PMC5570495)
2016
Bilsland, Alan E. ORCID: https://orcid.org/0000-0003-0957-3908, Spiliopoulou, Pavlina
ORCID: https://orcid.org/0000-0002-6486-6319 and Evans, T.R. Jeffry
ORCID: https://orcid.org/0000-0002-4175-914X
(2016)
Virotherapy: cancer gene therapy at last?
F1000Research, 5,
2105.
(doi: 10.12688/f1000research.8211.1)
(PMID:27635234)
(PMCID:PMC5007754)
Ali, A. et al. (2016) Investigating various thresholds as immunohistochemistry cutoffs for observer agreement. Applied Immunohistochemistry and Molecular Morphology, 25(9), pp. 599-608. (doi: 10.1097/PAI.0000000000000357) (PMID:27093449)
2015
Amin, A.R.M. R. et al. (2015) Evasion of anti-growth signaling: a key step in tumorigenesis and potential target for treatment and prophylaxis by natural compounds. Seminars in Cancer Biology, 35, S55-S77. (doi: 10.1016/j.semcancer.2015.02.005) (PMID:25749195) (PMCID:PMC4561219)
Casey, S. C. et al. (2015) Cancer prevention and therapy through the modulation of the tumor microenvironment. Seminars in Cancer Biology, 35, S199-S223. (doi: 10.1016/j.semcancer.2015.02.007) (PMID:25865775) (PMCID:PMC4930000)
Feitelson, M. A. et al. (2015) Sustained proliferation in cancer: mechanisms and novel therapeutic targets. Seminars in Cancer Biology, 35(Suppl), S25-S54. (doi: 10.1016/j.semcancer.2015.02.006) (PMID:25892662) (PMCID:PMC4898971)
Ferguson, L. R. et al. (2015) Genomic instability in human cancer: molecular insights and opportunities for therapeutic attack and prevention through diet and nutrition. Seminars in Cancer Biology, 35(Suppl), S5-S24. (doi: 10.1016/j.semcancer.2015.03.005) (PMID:25869442) (PMCID:PMC4600419)
Mohammad, R. M. et al. (2015) Broad targeting of resistance to apoptosis in cancer. Seminars in Cancer Biology, 35(Suppl.), S78-S103. (doi: 10.1016/j.semcancer.2015.03.001) (PMID:25936818)
Samadi, A. K. et al. (2015) A multi-targeted approach to suppress tumor-promoting inflammation. Seminars in Cancer Biology, 35(Suppl), S151-S184. (doi: 10.1016/j.semcancer.2015.03.006) (PMID:25951989) (PMCID:PMC4635070)
Vinay, D. S. et al. (2015) Immune evasion in cancer: mechanistic basis and therapeutic strategies. Seminars in Cancer Biology, 35(Suppl.), S185-S198. (doi: 10.1016/j.semcancer.2015.03.004) (PMID:25818339)
Wang, Z. et al. (2015) Broad targeting of angiogenesis for cancer prevention and therapy. Seminars in Cancer Biology, 35(Suppl.), S224-S243. (doi: 10.1016/j.semcancer.2015.01.001) (PMID:25600295) (PMCID:PMC4737670)
Yaswen, P. et al. (2015) Therapeutic targeting of replicative immortality. Seminars in Cancer Biology, 35(Supp.), S104-S128. (doi: 10.1016/j.semcancer.2015.03.007) (PMID:25869441) (PMCID:PMC4600408)
Bilsland, A. E. et al. (2015) Identification of a selective G1-phase benzimidazolone inhibitor by a senescence-targeted virtual screen using artificial neural networks. Neoplasia, 17(9), pp. 704-715. (doi: 10.1016/j.neo.2015.08.009) (PMID:26476078) (PMCID:PMC4611071)
Hartmann, Daniel, von Figura, Guido, Song, Zhangfa, Harden, Sharon, Scott, Lucy C, Evans, TR Jeffry ORCID: https://orcid.org/0000-0002-4175-914X, Rudolph, Karl Lenhard, Bilsland, Alan E
ORCID: https://orcid.org/0000-0003-0957-3908 and Keith, W Nicol
ORCID: https://orcid.org/0000-0001-7862-3580
(2015)
PlasmaN-acetyl-glucosaminidase in advanced gastro-intestinal adenocarcinoma correlates with age, stage and outcome.
Future Oncology, 11(2),
pp. 193-203.
(doi: 10.2217/fon.14.166)
2014
Bilsland, Alan E. ORCID: https://orcid.org/0000-0003-0957-3908, Stevenson, Katrina, Liu, Yu, Hoare, Stacey, Cairney, Claire J., Roffey, Jon and Keith, W. Nicol
ORCID: https://orcid.org/0000-0001-7862-3580
(2014)
Mathematical model of a telomerase transcriptional regulatory network developed by cell-based screening: analysis of inhibitor effects and telomerase expression mechanisms.
PLoS Computational Biology, 10(2),
e1003448.
(doi: 10.1371/journal.pcbi.1003448)
(PMID:24550717)
(PMCID:PMC3923661)
2013
Bilsland, Alan E. ORCID: https://orcid.org/0000-0003-0957-3908, Revie, John and Keith, W.Nicol
ORCID: https://orcid.org/0000-0001-7862-3580
(2013)
MicroRNA and senescence: the senectome, integration and distributed control.
Critical Reviews in Oncogenesis, 18(4),
pp. 373-390.
(doi: 10.1615/CritRevOncog.2013007197)
2012
Cairney, C.J., Bilsland, A.E. ORCID: https://orcid.org/0000-0003-0957-3908, Evans, T.R.J.
ORCID: https://orcid.org/0000-0002-4175-914X, Roffey, J., Bennett, D.C., Narita, M., Torrance, C. and Keith, W.N.
ORCID: https://orcid.org/0000-0001-7862-3580
(2012)
Cancer cell senescence: a new frontier in drug development.
Drug Discovery Today, 17(5-6),
pp. 269-276.
(doi: 10.1016/j.drudis.2012.01.019)
Keith, W.N. ORCID: https://orcid.org/0000-0001-7862-3580, Lafferty-Whyte, K, Cairney, C.J., Zaffaroni, N. and Bilsland, A.
ORCID: https://orcid.org/0000-0003-0957-3908
(2012)
Response to ‘Validating a gene expression signature proposed to differentiate liposarcomas that use different telomere maintenance mechanism.
Oncogene, 31(2),
pp. 267-268.
(doi: 10.1038/onc.2011.374)
2011
Bilsland, A.E. ORCID: https://orcid.org/0000-0003-0957-3908, Cairney, C.J. and Keith, W.N.
ORCID: https://orcid.org/0000-0001-7862-3580
(2011)
Targeting the telomere and shelterin complex for cancer therapy: current views and future perspectives.
Journal of Cellular and Molecular Medicine, 15(2),
pp. 179-186.
(doi: 10.1111/j.1582-4934.2010.01253.x)
2010
Lafferty-Whyte, K., Bilsland, A. ORCID: https://orcid.org/0000-0003-0957-3908, Hoare, S.F., Burns, S., Zaffaroni, N., Cairney, C.J. and Keith, W.N.
ORCID: https://orcid.org/0000-0001-7862-3580
(2010)
TCEAL7 inhibition of c-Myc activity in alternative lengthening of telomeres regulates hTERT expression.
Neoplasia, 12(5),
pp. 405-414.
Bilsland, Alan. E. ORCID: https://orcid.org/0000-0003-0957-3908 and Keith, W. Nicol
ORCID: https://orcid.org/0000-0001-7862-3580
(2010)
Mining cellular senescence for drug targets.
In: Adams, Peter. D. and Sedivy, John M. (eds.)
Cellular Senescence and Tumor Suppression.
Springer: New York, pp. 235-266.
ISBN 9781441910745
(doi: 10.1007/978-1-4419-1075-2_10)
Lafferty-Whyte, K. et al. (2010) Scoring of senescence signalling in multiple human tumour gene expression datasets, identification of a correlation between senescence score and drug toxicity in the NCI60 panel and a pro-inflammatory signature correlating with survival advantage in peritoneal mesothelioma. BMC Genomics, 11(1), p. 532. (doi: 10.1186/1471-2164-11-532)
Stolzenburg, S., Bilsland, A. ORCID: https://orcid.org/0000-0003-0957-3908, Keith, W.N.
ORCID: https://orcid.org/0000-0001-7862-3580 and Rots, M.G.
(2010)
Modulation of gene expression using zinc finger-based artificial transcription factors.
Methods in Molecular Biology, 649(2),
pp. 117-132.
(doi: 10.1007/978-1-60761-753-2_7)
2009
Lafferty-Whyte, K., Cairney, C.J., Will, M.B., Serakinci, N., Daidone, M.G., Zaffaroni, N., Bilsland, A.E. and Keith, W.N. ORCID: https://orcid.org/0000-0001-7862-3580
(2009)
A gene expression signature classifying telomerase and ALT immortalization reveals an hTERT regulatory network and suggests a mesenchymal stem cell origin for ALT.
Oncogene, 28(43),
pp. 3765-3774.
(doi: 10.1038/onc.2009.238)
Bilsland, A.E., Hoare, S.F., Stevenson, K.H., Plumb, J.A., Gomez-Roman, N. ORCID: https://orcid.org/0000-0002-2325-7517, Cairney, C.J., Burns, S., Lafferty-Whyte, K., Hammonds, T. and Keith, W.N.
ORCID: https://orcid.org/0000-0001-7862-3580
(2009)
Dynamic telomerase gene suppression via network effects of GSK3 inhibition.
PLoS ONE, 4(7),
e6459.
(doi: 10.1371/journal.pone.0006459)
(PMID:19649288)
(PMCID:PMC2714081)
2008
Keith, W.N. ORCID: https://orcid.org/0000-0001-7862-3580 and Bilsland, A.E.
(2008)
Targeting telomerase: therapeutic options for cancer treatment.
In: Rudolph, K.L. (ed.)
Telomeres and Telomerase in Aging, Disease, and Cancer: Molecular Mechanisms of Adult Stem Cell Ageing.
Springer: Berlin, Germany, pp. 247-283.
ISBN 9783540737087
(doi: 10.1007/978-3-540-73709-4_13)
2007
Bilsland, A.E. ORCID: https://orcid.org/0000-0003-0957-3908, Merron, A., Vassaux, G. and Keith, W.N.
ORCID: https://orcid.org/0000-0001-7862-3580
(2007)
Modulation of telomerase promoter tumor selectivity in the context of oncolytic adenoviruses.
Cancer Research, 67(3),
pp. 1299-1307.
(doi: 10.1158/0008-5472.CAN-06-3000)
2006
Anderson, C.J., Hoare, S.F., Ashcroft, M., Bilsland, A.E. ORCID: https://orcid.org/0000-0003-0957-3908 and Keith, W.N.
ORCID: https://orcid.org/0000-0001-7862-3580
(2006)
Hypoxic regulation of telomerase gene expression by transcriptional and post-transcriptional mechanisms.
Oncogene, 25(1),
pp. 61-69.
(doi: 10.1038/sj.onc.1209011)
2005
Zhao, J., Bilsland, A. ORCID: https://orcid.org/0000-0003-0957-3908, Jackson, K. and Keith, W.N.
ORCID: https://orcid.org/0000-0001-7862-3580
(2005)
MDM2 negatively regulates the human telomerase RNA gene promoter.
BMC Cancer, 5,
6.
(doi: 10.1186/1471-2407-5-6)
(PMID:15656906)
(PMCID:PMC546012)
Bilsland, A.E. ORCID: https://orcid.org/0000-0003-0957-3908, Fletcher-Monaghan, A. and Keith, W.N.
ORCID: https://orcid.org/0000-0001-7862-3580
(2005)
Properties of a telomerase-specific Cre/Lox switch for transcriptionally targeted cancer gene therapy.
Neoplasia, 7(11),
pp. 1020-1029.
(doi: 10.1593/neo.05385)
Dufes, C., Keith, W.N. ORCID: https://orcid.org/0000-0001-7862-3580, Proutski, I., Bilsland, A.
ORCID: https://orcid.org/0000-0003-0957-3908, Uchegbu, I.F. and Schõtzlein, A.G.
(2005)
Synthetic anti-cancer gene medicine exploits intrinsic anti-tumour activity of cationic vector to cure established tumours.
Cancer Research, 65(18),
pp. 8079-8084.
(doi: 10.1158/0008-5472.CAN-04-4402)
2004
Keith, W.N. et al. (2004) A mutation in a functional Sp1 binding site of the telomerase RNA gene (hTERC) promoter in a patient with Paroxysmal Nocturnal Haemoglobinuria. BMC Blood Disorders, 4(3), (doi: 10.1186/1471-2326-4-3)
Keith, WN ORCID: https://orcid.org/0000-0001-7862-3580, Bilsland, A
ORCID: https://orcid.org/0000-0003-0957-3908, Hardie, M and Evans, TRJ
ORCID: https://orcid.org/0000-0002-4175-914X
(2004)
Drug Insight: cancer cell immortality - telomerase as a target for novel cancer gene therapies.
Nature Clinical Practice Oncology, 1(2),
pp. 88-96.
(doi: 10.1038/ncponc0044)
2003
Bilsland, A.E. ORCID: https://orcid.org/0000-0003-0957-3908, Anderson, C.J., Fletcher-Monaghan, A.J., McGregor, F., Evans, T.R.J.
ORCID: https://orcid.org/0000-0002-4175-914X, Ganly, I., Knox, R.J., Plumb, J.A. and Keith, W.N.
ORCID: https://orcid.org/0000-0001-7862-3580
(2003)
Selective ablation of human cancer cells by telomerase-specific adenoviral suicide gene therapy vectors expressing bacterial nitroreductase.
Oncogene, 22(3),
pp. 370-380.
(doi: 10.1038/sj.onc.1206168)
Zhao, J.Q., Bilsland, A. ORCID: https://orcid.org/0000-0003-0957-3908, Hoare, S.F. and Keith, W.N.
ORCID: https://orcid.org/0000-0001-7862-3580
(2003)
Involvement of NF-Y and Sp1 binding sequences in basal transcription of the human telomerase RNA gene.
FEBS Letters, 536(1-3),
pp. 111-119.
(doi: 10.1016/S0014-5793(03)00038-3)
2002
Keith, W.N. ORCID: https://orcid.org/0000-0001-7862-3580, Bilsland, A.
ORCID: https://orcid.org/0000-0003-0957-3908, Evans, T.R.J.
ORCID: https://orcid.org/0000-0002-4175-914X and Glasspool, R.M.
(2002)
Telomerase-Directed Molecular Therapeutics.
Expert Reviews in Molecular Medicine(4),
pp. 1-25.
(doi: 10.1017/S1462399402004507)
2001
Plumb, J.A., Bilsland, A. ORCID: https://orcid.org/0000-0003-0957-3908, Kakani, R., Zhao, J.Q., Glasspool, R.M., Knox, R.J., Evans, T.R.J.
ORCID: https://orcid.org/0000-0002-4175-914X and Keith, W.N.
ORCID: https://orcid.org/0000-0001-7862-3580
(2001)
Telomerase-specific suicide gene therapy vectors expressing bacterial nitroreductase sensitize human cancer cells to the pro-drug CB1954.
Oncogene, 20(53),
pp. 7797-7803.
2000
Zhao, J.Q., Glasspool, R.M., Hoare, S.F., Bilsland, A. ORCID: https://orcid.org/0000-0003-0957-3908, Szatmari, I. and Keith, W.N.
ORCID: https://orcid.org/0000-0001-7862-3580
(2000)
Activation of telomerase RNA gene promoter activity by NF-Y, Sp1, and the retinoblastoma protein and repression by Sp3.
Neoplasia, 2(6),
pp. 531-539.
Articles
Seitz, Judith, Bilsland, Alan ORCID: https://orcid.org/0000-0003-0957-3908, Puget, Chloé, Baasner, Ian, Klopfleisch, Robert and Stein, Torsten
(2023)
SFRP1 expression is inversely associated with metastasis formation in canine mammary tumours.
Journal of Mammary Gland Biology and Neoplasia, 28(1),
p. 15.
(doi: 10.1007/s10911-023-09543-z)
(PMID:37402051)
Ibrahim, Ayman, Bilsland, Alan ORCID: https://orcid.org/0000-0003-0957-3908, Rickelt, Steffen, Morris, Joanna
ORCID: https://orcid.org/0000-0001-5975-2475 and Stein, Torsten
ORCID: https://orcid.org/0000-0002-9946-1549
(2021)
A matrisome RNA signature from early-pregnancy mouse mammary fibroblasts predicts distant metastasis-free breast cancer survival in humans.
Breast Cancer Research, 23,
90.
(doi: 10.1186/s13058-021-01470-3)
(PMID:34565423)
(PMCID:PMC8474794)
Bilsland, Alan E. ORCID: https://orcid.org/0000-0003-0957-3908, Liu, Yu, Turnbull, Andrew, Sumpton, David, Stevenson, Katrina, Cairney, Claire J., Boyd, Susan M., Roffey, Jon, Jenkinson, David and Keith, W. Nicol
ORCID: https://orcid.org/0000-0001-7862-3580
(2019)
A novel pyrazolopyrimidine ligand of human PGK1 and stress sensor DJ1 modulates the shelterin complex and telomere length regulation.
Neoplasia, 21(9),
pp. 893-907.
(doi: 10.1016/j.neo.2019.07.008)
(PMID:31401411)
(PMCID:PMC6700475)
Cairney, C. J. et al. (2017) A 'synthetic-sickness' screen for senescence re-engagement targets in mutant cancer backgrounds. PLoS Genetics, 13(8), e1006942. (doi: 10.1371/journal.pgen.1006942) (PMID:28806777) (PMCID:PMC5570495)
Bilsland, Alan E. ORCID: https://orcid.org/0000-0003-0957-3908, Spiliopoulou, Pavlina
ORCID: https://orcid.org/0000-0002-6486-6319 and Evans, T.R. Jeffry
ORCID: https://orcid.org/0000-0002-4175-914X
(2016)
Virotherapy: cancer gene therapy at last?
F1000Research, 5,
2105.
(doi: 10.12688/f1000research.8211.1)
(PMID:27635234)
(PMCID:PMC5007754)
Ali, A. et al. (2016) Investigating various thresholds as immunohistochemistry cutoffs for observer agreement. Applied Immunohistochemistry and Molecular Morphology, 25(9), pp. 599-608. (doi: 10.1097/PAI.0000000000000357) (PMID:27093449)
Amin, A.R.M. R. et al. (2015) Evasion of anti-growth signaling: a key step in tumorigenesis and potential target for treatment and prophylaxis by natural compounds. Seminars in Cancer Biology, 35, S55-S77. (doi: 10.1016/j.semcancer.2015.02.005) (PMID:25749195) (PMCID:PMC4561219)
Casey, S. C. et al. (2015) Cancer prevention and therapy through the modulation of the tumor microenvironment. Seminars in Cancer Biology, 35, S199-S223. (doi: 10.1016/j.semcancer.2015.02.007) (PMID:25865775) (PMCID:PMC4930000)
Feitelson, M. A. et al. (2015) Sustained proliferation in cancer: mechanisms and novel therapeutic targets. Seminars in Cancer Biology, 35(Suppl), S25-S54. (doi: 10.1016/j.semcancer.2015.02.006) (PMID:25892662) (PMCID:PMC4898971)
Ferguson, L. R. et al. (2015) Genomic instability in human cancer: molecular insights and opportunities for therapeutic attack and prevention through diet and nutrition. Seminars in Cancer Biology, 35(Suppl), S5-S24. (doi: 10.1016/j.semcancer.2015.03.005) (PMID:25869442) (PMCID:PMC4600419)
Mohammad, R. M. et al. (2015) Broad targeting of resistance to apoptosis in cancer. Seminars in Cancer Biology, 35(Suppl.), S78-S103. (doi: 10.1016/j.semcancer.2015.03.001) (PMID:25936818)
Samadi, A. K. et al. (2015) A multi-targeted approach to suppress tumor-promoting inflammation. Seminars in Cancer Biology, 35(Suppl), S151-S184. (doi: 10.1016/j.semcancer.2015.03.006) (PMID:25951989) (PMCID:PMC4635070)
Vinay, D. S. et al. (2015) Immune evasion in cancer: mechanistic basis and therapeutic strategies. Seminars in Cancer Biology, 35(Suppl.), S185-S198. (doi: 10.1016/j.semcancer.2015.03.004) (PMID:25818339)
Wang, Z. et al. (2015) Broad targeting of angiogenesis for cancer prevention and therapy. Seminars in Cancer Biology, 35(Suppl.), S224-S243. (doi: 10.1016/j.semcancer.2015.01.001) (PMID:25600295) (PMCID:PMC4737670)
Yaswen, P. et al. (2015) Therapeutic targeting of replicative immortality. Seminars in Cancer Biology, 35(Supp.), S104-S128. (doi: 10.1016/j.semcancer.2015.03.007) (PMID:25869441) (PMCID:PMC4600408)
Bilsland, A. E. et al. (2015) Identification of a selective G1-phase benzimidazolone inhibitor by a senescence-targeted virtual screen using artificial neural networks. Neoplasia, 17(9), pp. 704-715. (doi: 10.1016/j.neo.2015.08.009) (PMID:26476078) (PMCID:PMC4611071)
Hartmann, Daniel, von Figura, Guido, Song, Zhangfa, Harden, Sharon, Scott, Lucy C, Evans, TR Jeffry ORCID: https://orcid.org/0000-0002-4175-914X, Rudolph, Karl Lenhard, Bilsland, Alan E
ORCID: https://orcid.org/0000-0003-0957-3908 and Keith, W Nicol
ORCID: https://orcid.org/0000-0001-7862-3580
(2015)
PlasmaN-acetyl-glucosaminidase in advanced gastro-intestinal adenocarcinoma correlates with age, stage and outcome.
Future Oncology, 11(2),
pp. 193-203.
(doi: 10.2217/fon.14.166)
Bilsland, Alan E. ORCID: https://orcid.org/0000-0003-0957-3908, Stevenson, Katrina, Liu, Yu, Hoare, Stacey, Cairney, Claire J., Roffey, Jon and Keith, W. Nicol
ORCID: https://orcid.org/0000-0001-7862-3580
(2014)
Mathematical model of a telomerase transcriptional regulatory network developed by cell-based screening: analysis of inhibitor effects and telomerase expression mechanisms.
PLoS Computational Biology, 10(2),
e1003448.
(doi: 10.1371/journal.pcbi.1003448)
(PMID:24550717)
(PMCID:PMC3923661)
Bilsland, Alan E. ORCID: https://orcid.org/0000-0003-0957-3908, Revie, John and Keith, W.Nicol
ORCID: https://orcid.org/0000-0001-7862-3580
(2013)
MicroRNA and senescence: the senectome, integration and distributed control.
Critical Reviews in Oncogenesis, 18(4),
pp. 373-390.
(doi: 10.1615/CritRevOncog.2013007197)
Cairney, C.J., Bilsland, A.E. ORCID: https://orcid.org/0000-0003-0957-3908, Evans, T.R.J.
ORCID: https://orcid.org/0000-0002-4175-914X, Roffey, J., Bennett, D.C., Narita, M., Torrance, C. and Keith, W.N.
ORCID: https://orcid.org/0000-0001-7862-3580
(2012)
Cancer cell senescence: a new frontier in drug development.
Drug Discovery Today, 17(5-6),
pp. 269-276.
(doi: 10.1016/j.drudis.2012.01.019)
Keith, W.N. ORCID: https://orcid.org/0000-0001-7862-3580, Lafferty-Whyte, K, Cairney, C.J., Zaffaroni, N. and Bilsland, A.
ORCID: https://orcid.org/0000-0003-0957-3908
(2012)
Response to ‘Validating a gene expression signature proposed to differentiate liposarcomas that use different telomere maintenance mechanism.
Oncogene, 31(2),
pp. 267-268.
(doi: 10.1038/onc.2011.374)
Bilsland, A.E. ORCID: https://orcid.org/0000-0003-0957-3908, Cairney, C.J. and Keith, W.N.
ORCID: https://orcid.org/0000-0001-7862-3580
(2011)
Targeting the telomere and shelterin complex for cancer therapy: current views and future perspectives.
Journal of Cellular and Molecular Medicine, 15(2),
pp. 179-186.
(doi: 10.1111/j.1582-4934.2010.01253.x)
Lafferty-Whyte, K., Bilsland, A. ORCID: https://orcid.org/0000-0003-0957-3908, Hoare, S.F., Burns, S., Zaffaroni, N., Cairney, C.J. and Keith, W.N.
ORCID: https://orcid.org/0000-0001-7862-3580
(2010)
TCEAL7 inhibition of c-Myc activity in alternative lengthening of telomeres regulates hTERT expression.
Neoplasia, 12(5),
pp. 405-414.
Lafferty-Whyte, K. et al. (2010) Scoring of senescence signalling in multiple human tumour gene expression datasets, identification of a correlation between senescence score and drug toxicity in the NCI60 panel and a pro-inflammatory signature correlating with survival advantage in peritoneal mesothelioma. BMC Genomics, 11(1), p. 532. (doi: 10.1186/1471-2164-11-532)
Stolzenburg, S., Bilsland, A. ORCID: https://orcid.org/0000-0003-0957-3908, Keith, W.N.
ORCID: https://orcid.org/0000-0001-7862-3580 and Rots, M.G.
(2010)
Modulation of gene expression using zinc finger-based artificial transcription factors.
Methods in Molecular Biology, 649(2),
pp. 117-132.
(doi: 10.1007/978-1-60761-753-2_7)
Lafferty-Whyte, K., Cairney, C.J., Will, M.B., Serakinci, N., Daidone, M.G., Zaffaroni, N., Bilsland, A.E. and Keith, W.N. ORCID: https://orcid.org/0000-0001-7862-3580
(2009)
A gene expression signature classifying telomerase and ALT immortalization reveals an hTERT regulatory network and suggests a mesenchymal stem cell origin for ALT.
Oncogene, 28(43),
pp. 3765-3774.
(doi: 10.1038/onc.2009.238)
Bilsland, A.E., Hoare, S.F., Stevenson, K.H., Plumb, J.A., Gomez-Roman, N. ORCID: https://orcid.org/0000-0002-2325-7517, Cairney, C.J., Burns, S., Lafferty-Whyte, K., Hammonds, T. and Keith, W.N.
ORCID: https://orcid.org/0000-0001-7862-3580
(2009)
Dynamic telomerase gene suppression via network effects of GSK3 inhibition.
PLoS ONE, 4(7),
e6459.
(doi: 10.1371/journal.pone.0006459)
(PMID:19649288)
(PMCID:PMC2714081)
Bilsland, A.E. ORCID: https://orcid.org/0000-0003-0957-3908, Merron, A., Vassaux, G. and Keith, W.N.
ORCID: https://orcid.org/0000-0001-7862-3580
(2007)
Modulation of telomerase promoter tumor selectivity in the context of oncolytic adenoviruses.
Cancer Research, 67(3),
pp. 1299-1307.
(doi: 10.1158/0008-5472.CAN-06-3000)
Anderson, C.J., Hoare, S.F., Ashcroft, M., Bilsland, A.E. ORCID: https://orcid.org/0000-0003-0957-3908 and Keith, W.N.
ORCID: https://orcid.org/0000-0001-7862-3580
(2006)
Hypoxic regulation of telomerase gene expression by transcriptional and post-transcriptional mechanisms.
Oncogene, 25(1),
pp. 61-69.
(doi: 10.1038/sj.onc.1209011)
Zhao, J., Bilsland, A. ORCID: https://orcid.org/0000-0003-0957-3908, Jackson, K. and Keith, W.N.
ORCID: https://orcid.org/0000-0001-7862-3580
(2005)
MDM2 negatively regulates the human telomerase RNA gene promoter.
BMC Cancer, 5,
6.
(doi: 10.1186/1471-2407-5-6)
(PMID:15656906)
(PMCID:PMC546012)
Bilsland, A.E. ORCID: https://orcid.org/0000-0003-0957-3908, Fletcher-Monaghan, A. and Keith, W.N.
ORCID: https://orcid.org/0000-0001-7862-3580
(2005)
Properties of a telomerase-specific Cre/Lox switch for transcriptionally targeted cancer gene therapy.
Neoplasia, 7(11),
pp. 1020-1029.
(doi: 10.1593/neo.05385)
Dufes, C., Keith, W.N. ORCID: https://orcid.org/0000-0001-7862-3580, Proutski, I., Bilsland, A.
ORCID: https://orcid.org/0000-0003-0957-3908, Uchegbu, I.F. and Schõtzlein, A.G.
(2005)
Synthetic anti-cancer gene medicine exploits intrinsic anti-tumour activity of cationic vector to cure established tumours.
Cancer Research, 65(18),
pp. 8079-8084.
(doi: 10.1158/0008-5472.CAN-04-4402)
Keith, W.N. et al. (2004) A mutation in a functional Sp1 binding site of the telomerase RNA gene (hTERC) promoter in a patient with Paroxysmal Nocturnal Haemoglobinuria. BMC Blood Disorders, 4(3), (doi: 10.1186/1471-2326-4-3)
Keith, WN ORCID: https://orcid.org/0000-0001-7862-3580, Bilsland, A
ORCID: https://orcid.org/0000-0003-0957-3908, Hardie, M and Evans, TRJ
ORCID: https://orcid.org/0000-0002-4175-914X
(2004)
Drug Insight: cancer cell immortality - telomerase as a target for novel cancer gene therapies.
Nature Clinical Practice Oncology, 1(2),
pp. 88-96.
(doi: 10.1038/ncponc0044)
Bilsland, A.E. ORCID: https://orcid.org/0000-0003-0957-3908, Anderson, C.J., Fletcher-Monaghan, A.J., McGregor, F., Evans, T.R.J.
ORCID: https://orcid.org/0000-0002-4175-914X, Ganly, I., Knox, R.J., Plumb, J.A. and Keith, W.N.
ORCID: https://orcid.org/0000-0001-7862-3580
(2003)
Selective ablation of human cancer cells by telomerase-specific adenoviral suicide gene therapy vectors expressing bacterial nitroreductase.
Oncogene, 22(3),
pp. 370-380.
(doi: 10.1038/sj.onc.1206168)
Zhao, J.Q., Bilsland, A. ORCID: https://orcid.org/0000-0003-0957-3908, Hoare, S.F. and Keith, W.N.
ORCID: https://orcid.org/0000-0001-7862-3580
(2003)
Involvement of NF-Y and Sp1 binding sequences in basal transcription of the human telomerase RNA gene.
FEBS Letters, 536(1-3),
pp. 111-119.
(doi: 10.1016/S0014-5793(03)00038-3)
Keith, W.N. ORCID: https://orcid.org/0000-0001-7862-3580, Bilsland, A.
ORCID: https://orcid.org/0000-0003-0957-3908, Evans, T.R.J.
ORCID: https://orcid.org/0000-0002-4175-914X and Glasspool, R.M.
(2002)
Telomerase-Directed Molecular Therapeutics.
Expert Reviews in Molecular Medicine(4),
pp. 1-25.
(doi: 10.1017/S1462399402004507)
Plumb, J.A., Bilsland, A. ORCID: https://orcid.org/0000-0003-0957-3908, Kakani, R., Zhao, J.Q., Glasspool, R.M., Knox, R.J., Evans, T.R.J.
ORCID: https://orcid.org/0000-0002-4175-914X and Keith, W.N.
ORCID: https://orcid.org/0000-0001-7862-3580
(2001)
Telomerase-specific suicide gene therapy vectors expressing bacterial nitroreductase sensitize human cancer cells to the pro-drug CB1954.
Oncogene, 20(53),
pp. 7797-7803.
Zhao, J.Q., Glasspool, R.M., Hoare, S.F., Bilsland, A. ORCID: https://orcid.org/0000-0003-0957-3908, Szatmari, I. and Keith, W.N.
ORCID: https://orcid.org/0000-0001-7862-3580
(2000)
Activation of telomerase RNA gene promoter activity by NF-Y, Sp1, and the retinoblastoma protein and repression by Sp3.
Neoplasia, 2(6),
pp. 531-539.
Book Sections
Bilsland, Alan. E. ORCID: https://orcid.org/0000-0003-0957-3908 and Keith, W. Nicol
ORCID: https://orcid.org/0000-0001-7862-3580
(2010)
Mining cellular senescence for drug targets.
In: Adams, Peter. D. and Sedivy, John M. (eds.)
Cellular Senescence and Tumor Suppression.
Springer: New York, pp. 235-266.
ISBN 9781441910745
(doi: 10.1007/978-1-4419-1075-2_10)
Keith, W.N. ORCID: https://orcid.org/0000-0001-7862-3580 and Bilsland, A.E.
(2008)
Targeting telomerase: therapeutic options for cancer treatment.
In: Rudolph, K.L. (ed.)
Telomeres and Telomerase in Aging, Disease, and Cancer: Molecular Mechanisms of Adult Stem Cell Ageing.
Springer: Berlin, Germany, pp. 247-283.
ISBN 9783540737087
(doi: 10.1007/978-3-540-73709-4_13)
Conference or Workshop Item
Bilsland, Alan ORCID: https://orcid.org/0000-0003-0957-3908, Kelly, Caroline
ORCID: https://orcid.org/0000-0002-5330-7888, Roccisana, Jennifer, Paul, James
ORCID: https://orcid.org/0000-0001-7367-5816, Jones, Robert
ORCID: https://orcid.org/0000-0002-2904-6980, Edwards, Joanne
ORCID: https://orcid.org/0000-0002-7192-6906, Roseweir, Antonia
ORCID: https://orcid.org/0000-0001-6158-1564, Stein, Torsten
ORCID: https://orcid.org/0000-0002-9946-1549 and West, Katherine
ORCID: https://orcid.org/0000-0002-5994-8969
(2018)
An Exploratory Study on the Use of Game-based Learning Using Microsoft Kinect to Teach Oncology Phase I Clinical Trial Designs.
2018 NCRI Cancer Conference, Glasgow, UK, 04-06 Nov 2018.
(doi: 10.1038/s41416-018-0299-z)
Research datasets
2019
Bilsland, A. , Boyd, S., Turnbull, A., Jenkinson, D., Roffey, J. and Keith, N. (2019) Theoretical model of complex between phosphoglycerate kinase 1 and DJ1. [Data Collection]
Ross, K., Keith, N. , Aitchison, I., Allbutt, E., Banks, E., Basra, S., Bilsland, A., Charalambous, A., Chapal, C., Drummond, M., Dunipace, S., Erridge, A., Fremin-Besombes, M., Glasspool, R., Hamilton, V., Hanna, C. , Herfurth, L., Humpleby, M., Hush, G., Ivanova, Y., Jones, R. , Kaleta-Pyrek, A., Kalt, L., Kantor, M., Karolak, G., Keith, A., Klink, S., Laing, B., Lister, A., Mallon, E., Mccann, E., McLaughlin, R., Merchant, Z., Mozel, A., Mrozek, O., Painter, C., Paul, J. , Paxton, J., Perry, M. , Prendergast, E., Proudfoot, B., Raina, T., Roberts, F., Safrany, S., Scott, J., Sleight, R., Smith, C., Strain, E., Stricevic, M., Svanera, S., Tobias, E. , Vansteenhouse, H., Williams, N. and Zhang, H. (2019) A collaborative approach to exploring the future of Cancer treatment and care in relation to Precision Medicine: A design perspective. [Data Collection]
2018
Sumpton, D., Keith, N. and Bilsland, A. (2018) Identification of novel pyrazolopyrimidine compounds that modulate the shelterin complex and telomere length regulation via phosphoglycerate kinase 1 and stress sensor DJ1. [Data Collection]
Turnbull, A. P., Bilsland, A., Liu, Y., Sumpton, D., Stevenson, K., Cairney, C., Roffey, J., Jenkinson, D. and Keith, N. (2018) PGK1 in complex with CRT0063465 (3-[2-(4-bromophenyl)-5,7-dimethyl-pyrazolo[1,5-a]pyrimidin-6-yl]propanoic acid). [Data Collection]
2017
Keith, N. and Bilsland, A. (2017) Confirmatory assay for modulation of the human telomerase reverse transcriptase promoter in HCT116 cells. [Data Collection]
Keith, N. and Bilsland, A. (2017) Confirmatory dose-response cell survival assay for modulators of telomere damage signalling. [Data Collection]
Keith, N. and Bilsland, A. (2017) Luciferase assay for modulation of the human telomerase RNA component promoter. [Data Collection]
Cairney, C., Godwin, L., Bilsland, A., Burns, S., Stevenson, K., McGarry, L., Revie, J., Moore, J., Wiggans, C., Collinson, R., Mudd, C., Tsonou, E., Sadaie, M., Bennet, D., Narita, M., Torrance, C. and Keith, N. (2017) A ‘synthetic-sickness’ screen for senescence re-engagement targets in mutant cancer backgrounds. [Data Collection]
Keith, N. and Bilsland, A. (2017) Cell survival assay for modulators of telomere damage signalling. [Data Collection]
Keith, N. and Bilsland, A. (2017) Luciferase assay for modulation of the human telomerase reverse transcriptase promoter. [Data Collection]
2015
Bilsland, A., Pugliese, A., Liu, Y., Revie, J., Burns, S., McCormick, C., Cairney, C., Bower, J., Drysdale, M., Narita, M., Sadaie, M. and Keith, N. (2015) Identification of a selective G1-phase benzimidazolone inhibitor by a senescence-targeted virtual screen using artificial neural networks. [Data Collection]
2013
Bilsland, A. (2013) Statespaceminer app. [Data Collection]
2010
Lafferty-Whyte, K., Bilsland, A., Hoare, S., Burns, S., Zaffaroni, N., Cairney, C. and Keith, N. (2010) TCEAL7 Inhibition of c-Myc Activity in Alternative Lengthening of Telomeres Regulates hTERT Expression. [Data Collection]