Dr Andrew Campbell
- Affiliate- Prof Owen Sansom (School of Cancer Sciences)
email:
a.campbell@beatson.gla.ac.uk
CRUK Scotland Institute, Garscube Estate, Bearsden, G61 1BD
Publications
2024
Kiourtis, C. et al. (2024) Hepatocellular senescence induces multi-organ senescence and dysfunction via TGFβ. Nature Cell Biology, 26(12), pp. 2075-2083. (doi: 10.1038/s41556-024-01543-3) (PMID:39537753) (PMCID:PMC11628396)
Malla, S. B. et al. (2024) Author Correction: Pathway level subtyping identifies a slow-cycling biological phenotype associated with poor clinical outcomes in colorectal cancer. Nature Genetics, 56(6), 1321. (doi: 10.1038/s41588-024-01809-4) (PMID:38831011)
Malviya, G. et al. (2024) Noninvasive stratification of colon cancer by multiplex PET imaging. Clinical Cancer Research, 30(8), pp. 1518-1529. (doi: 10.1158/1078-0432.ccr-23-1063) (PMID:38493804) (PMCID:PMC11016897)
Fetit, R. et al. (2024) Characterising neutrophil subtypes in cancer using scRNA sequencing demonstrates the importance of IL-1β/CXCR2 axis in generation of metastasis specific neutrophils. Cancer Research Communications, 4(2), pp. 588-606. (doi: 10.1158/2767-9764.CRC-23-0319) (PMID:38358352) (PMCID:PMC10903300)
2023
Bailey, P. et al. (2023) Driver gene combinations dictate cutaneous squamous cell carcinoma disease continuum progression. Nature Communications, 14, 5211. (doi: 10.1038/s41467-023-40822-9) (PMID:37626054) (PMCID:PMC10457401)
Vande Voorde, J. et al. (2023) Metabolic profiling stratifies colorectal cancer and reveals adenosylhomocysteinase as a therapeutic target. Nature Metabolism, 5(8), pp. 1303-1318. (doi: 10.1038/s42255-023-00857-0) (PMID:37580540) (PMCID:PMC10447251)
Barry, Simon T., Gabrilovich, Dmitry I., Sansom, Owen J. 
ORCID: https://orcid.org/0000-0001-9540-3010, Campbell, Andrew D. and Morton, Jennifer P. ORCID: https://orcid.org/0000-0001-5766-9141
(2023)
Therapeutic targeting of tumour myeloid cells.
Nature Reviews Cancer, 23(4),
pp. 216-237.
(doi: 10.1038/s41568-022-00546-2)
(PMID:36747021)
Amirkhah, R. et al. (2023) MmCMS: mouse models' consensus molecular subtypes of colorectal cancer. British Journal of Cancer, 128(7), pp. 1333-1343. (doi: 10.1038/s41416-023-02157-6) (PMID:36717674) (PMCID:PMC10050155)
Chen, F. et al. (2023) RAC1B function is essential for breast cancer stem cell maintenance and chemoresistance of breast tumor cells. Oncogene, 42(9), pp. 679-692. (doi: 10.1038/s41388-022-02574-6) (PMID:36599922) (PMCID:PMC9957727)
2022
Flanagan, D. J. et al. (2022) Epithelial TGFβ engages growth-factor signalling to circumvent apoptosis and drive intestinal tumourigenesis with aggressive features. Nature Communications, 13, 7551. (doi: 10.1038/s41467-022-35134-3) (PMID:36477656) (PMCID:PMC9729215)
Corry, S. M. et al. (2022) Activation of innate-adaptive immune machinery by poly(I:C) exposes a therapeutic vulnerability to prevent relapse in stroma-rich colon cancer. Gut, 71(12), pp. 2502-2517. (doi: 10.1136/gutjnl-2021-326183) (PMID:35477539) (PMCID:PMC9664095)
2021
Heino, S. et al. (2021) Lef1 restricts ectopic crypt formation and tumor cell growth in intestinal adenomas. Science Advances, 7(47), eabj0512. (doi: 10.1126/sciadv.abj0512) (PMID:34788095) (PMCID:PMC8598008)
Nászai, M. et al. (2021) RAL GTPases mediate EGFR-driven intestinal stem cell proliferation and tumourigenesis. eLife, 10, e63807. (doi: 10.7554/eLife.63807) (PMID:34096503) (PMCID:PMC8216719)
Leach, J. D.G. et al. (2021) Oncogenic BRAF, unrestrained by TGFβ-receptor signalling, drives right-sided colonic tumorigenesis. Nature Communications, 12, 3464. (doi: 10.1038/s41467-021-23717-5) (PMID:34103493) (PMCID:PMC8187652)
Knight, J. R.P. et al. (2021) MNK inhibition sensitizes KRAS-mutant colorectal cancer to mTORC1 inhibition by reducing eIF4E phosphorylation and c-MYC expression. Cancer Discovery, 11(5), pp. 1228-1247. (doi: 10.1158/2159-8290.CD-20-0652) (PMID:33328217)
van der Weyden, L. et al. (2021) CRISPR activation screen in mice identifies novel membrane proteins enhancing pulmonary metastatic colonisation. Communications Biology, 4, 395. (doi: 10.1038/s42003-021-01912-w) (PMID:33758365) (PMCID:PMC7987976)
Swaminathan, Karthic, Campbell, Andrew, Papalazarou, Vasileios, Jaber-Hijazi, Farah ORCID: https://orcid.org/0000-0001-6094-751X, Nixon, Colin, McGhee, Ewan, Strathdee, Douglas, Sansom, Owen J. ORCID: https://orcid.org/0000-0001-9540-3010 and Machesky, Laura M. ORCID: https://orcid.org/0000-0002-7592-9856
(2021)
The RAC1 target NCKAP1 plays a crucial role in the progression of Braf;Pten-driven melanoma in mice.
Journal of Investigative Dermatology, 141(3),
628-637.e15.
(doi: 10.1016/j.jid.2020.06.029)
(PMID:32777214)
Race, A. M. et al. (2021) Deep learning-based annotation transfer between molecular imaging modalities: an automated workflow for multimodal data integration. Analytical Chemistry, 93(6), pp. 3061-3071. (doi: 10.1021/acs.analchem.0c02726) (PMID:33534548)
Murta, T. et al. (2021) Implications of peak selection in the interpretation of unsupervised mass spectrometry imaging data analyses. Analytical Chemistry, 93(4), pp. 2309-2316. (doi: 10.1021/acs.analchem.0c04179) (PMID:33395266)
Najumudeen, A. K. et al. (2021) The amino acid transporter SLC7A5 is required for efficient growth of KRAS-mutant colorectal cancer. Nature Genetics, 53, pp. 16-26. (doi: 10.1038/s41588-020-00753-3) (PMID:33414552)
Pickering, K.A. et al. (2021) A RAC-GEF network critical for early intestinal tumourigenesis. Nature Communications, 12, 56. (doi: 10.1038/s41467-020-20255-4) (PMID:33397922) (PMCID:PMC7782582)
2020
Michalopoulou, Evdokia, Auciello, Francesca R., Bulusu, Vinay, Strachan, David, Campbell, Andrew D., Tait-Mulder, Jacqueline, Karim, Saadia A., Morton, Jennifer P. ORCID: https://orcid.org/0000-0001-5766-9141, Sansom, Owen J. ORCID: https://orcid.org/0000-0001-9540-3010 and Kamphorst, Jurre J. ORCID: https://orcid.org/0000-0002-2042-5474
(2020)
Macropinocytosis renders a subset of pancreatic tumor cells resistant to mTOR inhibition.
Cell Reports, 30(8),
2729-2742.e4.
(doi: 10.1016/j.celrep.2020.01.080)
(PMID:32101748)
(PMCID:PMC7043007)
McGregor, G. H. et al. (2020) Targeting the metabolic response to statin-mediated oxidative stress produces a synergistic anti-tumor response. Cancer Research, 80(2), pp. 175-188. (doi: 10.1158/0008-5472.CAN-19-0644) (PMID:31562248)
2019
Jackstadt, R. et al. (2019) Epithelial NOTCH signaling rewires the tumor microenvironment of colorectal cancer to drive poor-prognosis subtypes and metastasis. Cancer Cell, 36(3), 319-336.e7. (doi: 10.1016/j.ccell.2019.08.003) (PMID:31526760) (PMCID:PMC6853173)
Johansson, J. et al. (2019) RAL GTPases drive intestinal stem cell function and regeneration through internalization of WNT signalosomes. Cell Stem Cell, 24(4), 592-607.E7. (doi: 10.1016/j.stem.2019.02.002) (PMID:30853556) (PMCID:PMC6459002)
Gay, D. M. et al. (2019) Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer. Nature Communications, 10, 723. (doi: 10.1038/s41467-019-08586-3) (PMID:30760720) (PMCID:PMC6374445)
Menon, M. et al. (2019) A novel tankyrase inhibitor, MSC2504877, enhances the effects of clinical CDK4/6 inhibitors. Scientific Reports, 9, 201. (doi: 10.1038/s41598-018-36447-4) (PMID:30655555) (PMCID:PMC6336890)
2018
Bird, T. G. et al. (2018) TGFβ inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence. Science Translational Medicine, 10(454), eaan1230. (doi: 10.1126/scitranslmed.aan1230) (PMID:30111642) (PMCID:PMC6420144)
Candido, J. B. et al. (2018) CSF1R+ macrophages sustain pancreatic tumor growth through T cell suppression and maintenance of key gene programs that define the squamous subtype. Cell Reports, 23(5), pp. 1448-1460. (doi: 10.1016/j.celrep.2018.03.131) (PMID:29719257) (PMCID:PMC5946718)
Huels, D.J. et al. (2018) Wnt ligands influence tumour initiation by controlling the number of intestinal stem cells. Nature Communications, 9, 1132. (doi: 10.1038/s41467-018-03426-2) (PMID:29556067) (PMCID:PMC5859272)
Unal, E. Besray, Kiel, Christina, Benisty, Hannah, Campbell, Andrew, Pickering, Karen, Blüthgen, Nils, Sansom, Owen J. ORCID: https://orcid.org/0000-0001-9540-3010 and Serrano, Luis
(2018)
Systems level expression correlation of Ras GTPase regulators.
Cell Communication and Signaling, 16,
46.
(doi: 10.1186/s12964-018-0256-8)
(PMID:30111366)
(PMCID:PMC6094892)
2017
Cammareri, P. et al. (2017) TGFβ pathway limits dedifferentiation following WNT and MAPK pathway activation to suppress intestinal tumourigenesis. Cell Death and Differentiation, 24(10), pp. 1681-1693. (doi: 10.1038/cdd.2017.92) (PMID:28622298)
Gundry, C. et al. (2017) Phosphorylation of Rab-coupling protein by LMTK3 controls Rab14-dependent EphA2 trafficking to promote cell:cell repulsion. Nature Communications, 8, 14646. (doi: 10.1038/ncomms14646) (PMID:28294115) (PMCID:PMC5355957)
van der Weyden, L. et al. (2017) Genome-wide in vivo screen identifies novel host regulators of metastatic colonization. Nature, 541(7636), pp. 233-236. (doi: 10.1038/nature20792) (PMID:28052056)
2016
Birch, J. et al. (2016) The initiator methionine tRNA drives cell migration and invasion leading to increased metastatic potential in melanoma. Biology Open, 5(10), pp. 1371-1379. (doi: 10.1242/bio.019075) (PMID:27543055) (PMCID:PMC5087684)
Wörmann, S. M. et al. (2016) Loss of P53 function activates JAK2–STAT3 signaling to promote pancreatic tumor growth, stroma modification, and gemcitabine resistance in mice and is associated with patient survival. Gastroenterology, 151(1), 180-193.e12. (doi: 10.1053/j.gastro.2016.03.010) (PMID:27003603)
Clarke, C. J. et al. (2016) The initiator methionine tRNA drives secretion of type II collagen from stromal fibroblasts to promote tumor growth and angiogenesis. Current Biology, 26(6), pp. 755-765. (doi: 10.1016/j.cub.2016.01.045) (PMID:26948875) (PMCID:PMC4819511)
Erami Rud Majani, Z. et al. (2016) Intravital FRAP imaging using an E-cadherin-GFP mouse reveals disease- and drug-dependent dynamic regulation of cell-cell junctions in live tissue. Cell Reports, 14(1), pp. 152-167. (doi: 10.1016/j.celrep.2015.12.020) (PMID:26725115)
2015
Huels, D. J. et al. (2015) E‐cadherin can limit the transforming properties of activating β‐catenin mutations. EMBO Journal, 34(18), pp. 2321-2333. (doi: 10.15252/embj.201591739) (PMID:26240067) (PMCID:PMC4570519)
von Karstedt, S. et al. (2015) Cancer cell-autonomous trail-r signaling promotes kras-driven cancer progression, invasion, and metastasis. Cancer Cell, 27(4), pp. 561-573. (doi: 10.1016/j.ccell.2015.02.014) (PMID:25843002) (PMCID:PMC6591140)
Conde-Perez, A. et al. (2015) A caveolin-dependent and PI3K/AKT-independent role of PTEN in β-catenin transcriptional activity. Nature Communications, 6, 8093. (doi: 10.1038/ncomms9093) (PMID:26307673) (PMCID:PMC4560817)
2013
Campbell, A.D., Lawn, S., McGarry, L.C., Welch, H.C., Ozanne, B.W. and Norman, J.C. ORCID: https://orcid.org/0000-0002-0098-3014
(2013)
P-rex1 cooperates with PDGFRβ to drive cellular migration in 3D microenvironments.
PLoS ONE, 8(1),
e53982.
(doi: 10.1371/journal.pone.0053982)
(PMID:23382862)
(PMCID:PMC3559689)
Nobis, M. et al. (2013) Intravital FLIM-FRET imaging reveals dasatinib-induced spatial control of Src in pancreatic cancer. Cancer Research, 73(15), pp. 4674-4686. (doi: 10.1158/0008-5472.CAN-12-4545)
2011
Lindsay, C.C.R. et al. (2011) P-Rex1 is required for efficient melanoblast migration and melanoma metastasis. Nature Communications, 2, pp. 1-9. (doi: 10.1038/ncomms1560)
Articles
Kiourtis, C. et al. (2024) Hepatocellular senescence induces multi-organ senescence and dysfunction via TGFβ. Nature Cell Biology, 26(12), pp. 2075-2083. (doi: 10.1038/s41556-024-01543-3) (PMID:39537753) (PMCID:PMC11628396)
Malla, S. B. et al. (2024) Author Correction: Pathway level subtyping identifies a slow-cycling biological phenotype associated with poor clinical outcomes in colorectal cancer. Nature Genetics, 56(6), 1321. (doi: 10.1038/s41588-024-01809-4) (PMID:38831011)
Malviya, G. et al. (2024) Noninvasive stratification of colon cancer by multiplex PET imaging. Clinical Cancer Research, 30(8), pp. 1518-1529. (doi: 10.1158/1078-0432.ccr-23-1063) (PMID:38493804) (PMCID:PMC11016897)
Fetit, R. et al. (2024) Characterising neutrophil subtypes in cancer using scRNA sequencing demonstrates the importance of IL-1β/CXCR2 axis in generation of metastasis specific neutrophils. Cancer Research Communications, 4(2), pp. 588-606. (doi: 10.1158/2767-9764.CRC-23-0319) (PMID:38358352) (PMCID:PMC10903300)
Bailey, P. et al. (2023) Driver gene combinations dictate cutaneous squamous cell carcinoma disease continuum progression. Nature Communications, 14, 5211. (doi: 10.1038/s41467-023-40822-9) (PMID:37626054) (PMCID:PMC10457401)
Vande Voorde, J. et al. (2023) Metabolic profiling stratifies colorectal cancer and reveals adenosylhomocysteinase as a therapeutic target. Nature Metabolism, 5(8), pp. 1303-1318. (doi: 10.1038/s42255-023-00857-0) (PMID:37580540) (PMCID:PMC10447251)
Barry, Simon T., Gabrilovich, Dmitry I., Sansom, Owen J. ORCID: https://orcid.org/0000-0001-9540-3010, Campbell, Andrew D. and Morton, Jennifer P. ORCID: https://orcid.org/0000-0001-5766-9141
(2023)
Therapeutic targeting of tumour myeloid cells.
Nature Reviews Cancer, 23(4),
pp. 216-237.
(doi: 10.1038/s41568-022-00546-2)
(PMID:36747021)
Amirkhah, R. et al. (2023) MmCMS: mouse models' consensus molecular subtypes of colorectal cancer. British Journal of Cancer, 128(7), pp. 1333-1343. (doi: 10.1038/s41416-023-02157-6) (PMID:36717674) (PMCID:PMC10050155)
Chen, F. et al. (2023) RAC1B function is essential for breast cancer stem cell maintenance and chemoresistance of breast tumor cells. Oncogene, 42(9), pp. 679-692. (doi: 10.1038/s41388-022-02574-6) (PMID:36599922) (PMCID:PMC9957727)
Flanagan, D. J. et al. (2022) Epithelial TGFβ engages growth-factor signalling to circumvent apoptosis and drive intestinal tumourigenesis with aggressive features. Nature Communications, 13, 7551. (doi: 10.1038/s41467-022-35134-3) (PMID:36477656) (PMCID:PMC9729215)
Corry, S. M. et al. (2022) Activation of innate-adaptive immune machinery by poly(I:C) exposes a therapeutic vulnerability to prevent relapse in stroma-rich colon cancer. Gut, 71(12), pp. 2502-2517. (doi: 10.1136/gutjnl-2021-326183) (PMID:35477539) (PMCID:PMC9664095)
Heino, S. et al. (2021) Lef1 restricts ectopic crypt formation and tumor cell growth in intestinal adenomas. Science Advances, 7(47), eabj0512. (doi: 10.1126/sciadv.abj0512) (PMID:34788095) (PMCID:PMC8598008)
Nászai, M. et al. (2021) RAL GTPases mediate EGFR-driven intestinal stem cell proliferation and tumourigenesis. eLife, 10, e63807. (doi: 10.7554/eLife.63807) (PMID:34096503) (PMCID:PMC8216719)
Leach, J. D.G. et al. (2021) Oncogenic BRAF, unrestrained by TGFβ-receptor signalling, drives right-sided colonic tumorigenesis. Nature Communications, 12, 3464. (doi: 10.1038/s41467-021-23717-5) (PMID:34103493) (PMCID:PMC8187652)
Knight, J. R.P. et al. (2021) MNK inhibition sensitizes KRAS-mutant colorectal cancer to mTORC1 inhibition by reducing eIF4E phosphorylation and c-MYC expression. Cancer Discovery, 11(5), pp. 1228-1247. (doi: 10.1158/2159-8290.CD-20-0652) (PMID:33328217)
van der Weyden, L. et al. (2021) CRISPR activation screen in mice identifies novel membrane proteins enhancing pulmonary metastatic colonisation. Communications Biology, 4, 395. (doi: 10.1038/s42003-021-01912-w) (PMID:33758365) (PMCID:PMC7987976)
Swaminathan, Karthic, Campbell, Andrew, Papalazarou, Vasileios, Jaber-Hijazi, Farah ORCID: https://orcid.org/0000-0001-6094-751X, Nixon, Colin, McGhee, Ewan, Strathdee, Douglas, Sansom, Owen J. ORCID: https://orcid.org/0000-0001-9540-3010 and Machesky, Laura M. ORCID: https://orcid.org/0000-0002-7592-9856
(2021)
The RAC1 target NCKAP1 plays a crucial role in the progression of Braf;Pten-driven melanoma in mice.
Journal of Investigative Dermatology, 141(3),
628-637.e15.
(doi: 10.1016/j.jid.2020.06.029)
(PMID:32777214)
Race, A. M. et al. (2021) Deep learning-based annotation transfer between molecular imaging modalities: an automated workflow for multimodal data integration. Analytical Chemistry, 93(6), pp. 3061-3071. (doi: 10.1021/acs.analchem.0c02726) (PMID:33534548)
Murta, T. et al. (2021) Implications of peak selection in the interpretation of unsupervised mass spectrometry imaging data analyses. Analytical Chemistry, 93(4), pp. 2309-2316. (doi: 10.1021/acs.analchem.0c04179) (PMID:33395266)
Najumudeen, A. K. et al. (2021) The amino acid transporter SLC7A5 is required for efficient growth of KRAS-mutant colorectal cancer. Nature Genetics, 53, pp. 16-26. (doi: 10.1038/s41588-020-00753-3) (PMID:33414552)
Pickering, K.A. et al. (2021) A RAC-GEF network critical for early intestinal tumourigenesis. Nature Communications, 12, 56. (doi: 10.1038/s41467-020-20255-4) (PMID:33397922) (PMCID:PMC7782582)
Michalopoulou, Evdokia, Auciello, Francesca R., Bulusu, Vinay, Strachan, David, Campbell, Andrew D., Tait-Mulder, Jacqueline, Karim, Saadia A., Morton, Jennifer P. ORCID: https://orcid.org/0000-0001-5766-9141, Sansom, Owen J. ORCID: https://orcid.org/0000-0001-9540-3010 and Kamphorst, Jurre J. ORCID: https://orcid.org/0000-0002-2042-5474
(2020)
Macropinocytosis renders a subset of pancreatic tumor cells resistant to mTOR inhibition.
Cell Reports, 30(8),
2729-2742.e4.
(doi: 10.1016/j.celrep.2020.01.080)
(PMID:32101748)
(PMCID:PMC7043007)
McGregor, G. H. et al. (2020) Targeting the metabolic response to statin-mediated oxidative stress produces a synergistic anti-tumor response. Cancer Research, 80(2), pp. 175-188. (doi: 10.1158/0008-5472.CAN-19-0644) (PMID:31562248)
Jackstadt, R. et al. (2019) Epithelial NOTCH signaling rewires the tumor microenvironment of colorectal cancer to drive poor-prognosis subtypes and metastasis. Cancer Cell, 36(3), 319-336.e7. (doi: 10.1016/j.ccell.2019.08.003) (PMID:31526760) (PMCID:PMC6853173)
Johansson, J. et al. (2019) RAL GTPases drive intestinal stem cell function and regeneration through internalization of WNT signalosomes. Cell Stem Cell, 24(4), 592-607.E7. (doi: 10.1016/j.stem.2019.02.002) (PMID:30853556) (PMCID:PMC6459002)
Gay, D. M. et al. (2019) Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer. Nature Communications, 10, 723. (doi: 10.1038/s41467-019-08586-3) (PMID:30760720) (PMCID:PMC6374445)
Menon, M. et al. (2019) A novel tankyrase inhibitor, MSC2504877, enhances the effects of clinical CDK4/6 inhibitors. Scientific Reports, 9, 201. (doi: 10.1038/s41598-018-36447-4) (PMID:30655555) (PMCID:PMC6336890)
Bird, T. G. et al. (2018) TGFβ inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence. Science Translational Medicine, 10(454), eaan1230. (doi: 10.1126/scitranslmed.aan1230) (PMID:30111642) (PMCID:PMC6420144)
Candido, J. B. et al. (2018) CSF1R+ macrophages sustain pancreatic tumor growth through T cell suppression and maintenance of key gene programs that define the squamous subtype. Cell Reports, 23(5), pp. 1448-1460. (doi: 10.1016/j.celrep.2018.03.131) (PMID:29719257) (PMCID:PMC5946718)
Huels, D.J. et al. (2018) Wnt ligands influence tumour initiation by controlling the number of intestinal stem cells. Nature Communications, 9, 1132. (doi: 10.1038/s41467-018-03426-2) (PMID:29556067) (PMCID:PMC5859272)
Unal, E. Besray, Kiel, Christina, Benisty, Hannah, Campbell, Andrew, Pickering, Karen, Blüthgen, Nils, Sansom, Owen J. ORCID: https://orcid.org/0000-0001-9540-3010 and Serrano, Luis
(2018)
Systems level expression correlation of Ras GTPase regulators.
Cell Communication and Signaling, 16,
46.
(doi: 10.1186/s12964-018-0256-8)
(PMID:30111366)
(PMCID:PMC6094892)
Cammareri, P. et al. (2017) TGFβ pathway limits dedifferentiation following WNT and MAPK pathway activation to suppress intestinal tumourigenesis. Cell Death and Differentiation, 24(10), pp. 1681-1693. (doi: 10.1038/cdd.2017.92) (PMID:28622298)
Gundry, C. et al. (2017) Phosphorylation of Rab-coupling protein by LMTK3 controls Rab14-dependent EphA2 trafficking to promote cell:cell repulsion. Nature Communications, 8, 14646. (doi: 10.1038/ncomms14646) (PMID:28294115) (PMCID:PMC5355957)
van der Weyden, L. et al. (2017) Genome-wide in vivo screen identifies novel host regulators of metastatic colonization. Nature, 541(7636), pp. 233-236. (doi: 10.1038/nature20792) (PMID:28052056)
Birch, J. et al. (2016) The initiator methionine tRNA drives cell migration and invasion leading to increased metastatic potential in melanoma. Biology Open, 5(10), pp. 1371-1379. (doi: 10.1242/bio.019075) (PMID:27543055) (PMCID:PMC5087684)
Wörmann, S. M. et al. (2016) Loss of P53 function activates JAK2–STAT3 signaling to promote pancreatic tumor growth, stroma modification, and gemcitabine resistance in mice and is associated with patient survival. Gastroenterology, 151(1), 180-193.e12. (doi: 10.1053/j.gastro.2016.03.010) (PMID:27003603)
Clarke, C. J. et al. (2016) The initiator methionine tRNA drives secretion of type II collagen from stromal fibroblasts to promote tumor growth and angiogenesis. Current Biology, 26(6), pp. 755-765. (doi: 10.1016/j.cub.2016.01.045) (PMID:26948875) (PMCID:PMC4819511)
Erami Rud Majani, Z. et al. (2016) Intravital FRAP imaging using an E-cadherin-GFP mouse reveals disease- and drug-dependent dynamic regulation of cell-cell junctions in live tissue. Cell Reports, 14(1), pp. 152-167. (doi: 10.1016/j.celrep.2015.12.020) (PMID:26725115)
Huels, D. J. et al. (2015) E‐cadherin can limit the transforming properties of activating β‐catenin mutations. EMBO Journal, 34(18), pp. 2321-2333. (doi: 10.15252/embj.201591739) (PMID:26240067) (PMCID:PMC4570519)
von Karstedt, S. et al. (2015) Cancer cell-autonomous trail-r signaling promotes kras-driven cancer progression, invasion, and metastasis. Cancer Cell, 27(4), pp. 561-573. (doi: 10.1016/j.ccell.2015.02.014) (PMID:25843002) (PMCID:PMC6591140)
Conde-Perez, A. et al. (2015) A caveolin-dependent and PI3K/AKT-independent role of PTEN in β-catenin transcriptional activity. Nature Communications, 6, 8093. (doi: 10.1038/ncomms9093) (PMID:26307673) (PMCID:PMC4560817)
Campbell, A.D., Lawn, S., McGarry, L.C., Welch, H.C., Ozanne, B.W. and Norman, J.C. ORCID: https://orcid.org/0000-0002-0098-3014
(2013)
P-rex1 cooperates with PDGFRβ to drive cellular migration in 3D microenvironments.
PLoS ONE, 8(1),
e53982.
(doi: 10.1371/journal.pone.0053982)
(PMID:23382862)
(PMCID:PMC3559689)
Nobis, M. et al. (2013) Intravital FLIM-FRET imaging reveals dasatinib-induced spatial control of Src in pancreatic cancer. Cancer Research, 73(15), pp. 4674-4686. (doi: 10.1158/0008-5472.CAN-12-4545)
Lindsay, C.C.R. et al. (2011) P-Rex1 is required for efficient melanoblast migration and melanoma metastasis. Nature Communications, 2, pp. 1-9. (doi: 10.1038/ncomms1560)