Dr David Sumpton
- Honorary Senior Lecturer (School of Cancer Sciences)
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Boscenco, S. et al. (2025) Functionally dominant hotspot mutations of mitochondrial ribosomal RNA genes in cancer. Nature Genetics, (doi: 10.1038/s41588-025-02374-0) (Early Online Publication)
Whyte, D. et al. (2025) Uridine phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes. EMBO Reports, 26(17), pp. 4248-4282. (doi: 10.1038/s44319-025-00520-7) (PMID:40702342) (PMCID:PMC12420820)
Gounis, M. et al. (2025) Metabolic adaptations of micrometastases alter EV production to generate invasive microenvironments. Journal of Cell Biology, 224(8), e202405061. (doi: 10.1083/jcb.202405061)
Kiourtis, C. et al. (2024) Hepatocellular senescence induces multi-organ senescence and dysfunction via TGFβ. Nature Cell Biology, 26(12), pp. 2075-2083. (doi: 10.1038/s41556-024-01543-3) (PMID:39537753) (PMCID:PMC11628396)
Jans, M. et al. (2024) Colibactin-driven colon cancer requires adhesin-mediated epithelial binding. Nature, 635(8038), pp. 472-480. (doi: 10.1038/s41586-024-08135-z) (PMID:39506107)
Khalaf, A. et al. (2024) Nutrient-sensitizing drug repurposing screen identifies lomerizine as a mitochondrial metabolism inhibitor of chronic myeloid leukemia. Science Translational Medicine, 16(751), eadi5336. (doi: 10.1126/scitranslmed.adi5336) (PMID:38865484)
Zarou, M. M. et al. (2024) Inhibition of mitochondrial folate metabolism drives differentiation through mTORC1-mediated purine sensing. Nature Communications, 15, 1931. (doi: 10.1038/s41467-024-46114-0) (PMID:38431691) (PMCID:PMC10908830)
Boscenco, S. et al. (2025) Functionally dominant hotspot mutations of mitochondrial ribosomal RNA genes in cancer. Nature Genetics, (doi: 10.1038/s41588-025-02374-0) (Early Online Publication)
Whyte, D. et al. (2025) Uridine phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes. EMBO Reports, 26(17), pp. 4248-4282. (doi: 10.1038/s44319-025-00520-7) (PMID:40702342) (PMCID:PMC12420820)
Gounis, M. et al. (2025) Metabolic adaptations of micrometastases alter EV production to generate invasive microenvironments. Journal of Cell Biology, 224(8), e202405061. (doi: 10.1083/jcb.202405061)
Kiourtis, C. et al. (2024) Hepatocellular senescence induces multi-organ senescence and dysfunction via TGFβ. Nature Cell Biology, 26(12), pp. 2075-2083. (doi: 10.1038/s41556-024-01543-3) (PMID:39537753) (PMCID:PMC11628396)
Jans, M. et al. (2024) Colibactin-driven colon cancer requires adhesin-mediated epithelial binding. Nature, 635(8038), pp. 472-480. (doi: 10.1038/s41586-024-08135-z) (PMID:39506107)
Khalaf, A. et al. (2024) Nutrient-sensitizing drug repurposing screen identifies lomerizine as a mitochondrial metabolism inhibitor of chronic myeloid leukemia. Science Translational Medicine, 16(751), eadi5336. (doi: 10.1126/scitranslmed.adi5336) (PMID:38865484)
Zarou, M. M. et al. (2024) Inhibition of mitochondrial folate metabolism drives differentiation through mTORC1-mediated purine sensing. Nature Communications, 15, 1931. (doi: 10.1038/s41467-024-46114-0) (PMID:38431691) (PMCID:PMC10908830)