Professor Ewan Cameron

  • Head of School / Professor (Veterinary Pathology, Public Health & Disease Investigation)
  • Associate (Institute of Cancer Sciences)

Personal assistant: Mrs Julie Norden
telephone: 01413305702
email: Julie.Norden@glasgow.ac.uk

Research interests

My main area of research is to identify key genes and pathways involved in human cancer, particularly leukaemia. Current work is focused on the Runx genes, a three-member family of transcription factors (RUNX1-3) that play critical roles in lineage development. RUNX1, a master regulator of haematopoiesis, is frequently disrupted in childhood leukaemia providing unequivocal evidence that inhibiting or altering the normal function of this gene can predispose to this disease. Paradoxically, our work has shown that, in addition to this tumour suppressor role, enhanced Runx1 activity can also result in leukaemia/lymphoma development. We are working to understand the mechanisms by which the RUNX genes can operate as double-agents in cancer - protecting against disease in some contexts and driving the process in others.

Acute Lymphoblastic Leukaemia (ALL) is the commonest form of leukaemia in children and the translocation most frequently associated with the common form of this disease is TEL-RUNX1, a fusion oncogene that preserves almost the entire coding sequence of RUNX1. Current work in the lab is aimed at understanding the oncogenic effects and the lineage specificity of this onco-protein as well as identifying the genes and pathways that are required for disease progression. A key feature of our approach is the use of retroviral agents to identify collaborating oncogenes and gain greater understanding of the nature of oncogenic synergy.

The role of Runx genes in cancer is also being examined in breast cancer where we have a project to investigate the function of Runx2 in mammary cell development, neoplasia and metastasis. This work is being carried out in collaboration with the Beatson Institute for Cancer Research. The group is supported by Leukaemia Lymphoma Research, Cancer Research UK and the Association for International Cancer Research.


Publications

List by: Type | Date

Jump to: 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000 | 1997 | 1996
Number of items: 47.

2019

Hay, J. , Gilroy, K., Huser, C. , Kilbey, A., Mcdonald, A., MacCallum, A., Holroyd, A. , Cameron, E. and Neil, J. C. (2019) Collaboration of MYC and RUNX2 in lymphoma simulates T‐cell receptor signaling and attenuates p53 pathway activity. Journal of Cellular Biochemistry, 120(10), pp. 18332-18345. (doi:10.1002/jcb.29143) (PMID:31257681) (PMCID:PMC6772115)

2018

Anderson, G. et al. (2018) RUNX-mediated growth arrest and senescence are attenuated by diverse mechanisms in cells expressing RUNX1 fusion oncoproteins. Journal of Cellular Biochemistry, 119(3), pp. 2750-2762. (doi:10.1002/jcb.26443) (PMID:29052866) (PMCID:PMC5813226)

McCarroll, C. S. et al. (2018) Runx1 deficiency protects against adverse cardiac remodeling after myocardial infarction. Circulation, 137(1), pp. 57-70. (doi:10.1161/CIRCULATIONAHA.117.028911) (PMID:29030345) (PMCID:PMC5757664)

2017

Kilbey, A. et al. (2017) Runx1 orchestrates sphingolipid metabolism and glucocorticoid resistance in lymphomagenesis. Journal of Cellular Biochemistry, 118(6), pp. 1432-1441. (doi:10.1002/jcb.25802) (PMID:27869314) (PMCID:5408393)

Rooney, N., Riggio, A. I., Mendoza-Villanueva, D., Shore, P., Cameron, E. R. and Blyth, K. (2017) Runx genes in breast cancer and the mammary lineage. In: Groner, Y., Ito, Y., Liu, P., Neil, J. C., Speck, N. A. and van Wijnen, A. (eds.) RUNX Proteins in Development and Cancer. Series: Advances in experimental medicine and biology, 96 (962). Springer, pp. 353-368. ISBN 9789811032318 (doi:10.1007/978-981-10-3233-2_22)

Terry, A., Kilbey, A., Naseer, A., Levy, L. S., Ahmad, S., Watts, C., Mackay, N., Cameron, E. , Wilson, S. and Neil, J. C. (2017) Barriers to infection of human cells by feline leukemia virus: insights into resistance to zoonosis. Journal of Virology, 91(5), e02119-16. (doi:10.1128/JVI.02119-16) (PMID:28031367) (PMCID:PMC5309941)

2016

Gilroy, K. L. et al. (2016) Gamma-retrovirus integration marks cell type-specific cancer genes: a novel profiling tool in cancer genomics. PLoS ONE, 11(4), e0154070. (doi:10.1371/journal.pone.0154070) (PMID:27097319) (PMCID:PMC4838236)

Borland, G. et al. (2016) Addiction to Runx1 is partially attenuated by loss of p53 in the Eμ-Myc lymphoma model. Oncotarget, 7(17), pp. 22973-22987. (doi:10.18632/oncotarget.8554) (PMID:27056890) (PMCID:PMC5029604)

2015

Naseer, A. et al. (2015) Frequent infection of human cancer xenografts with murine endogenous retroviruses in vivo. Viruses, 7(4), pp. 2014-2029. (doi:10.3390/v7042014) (PMID:25912714) (PMCID:PMC4411688)

Ferrari, N. et al. (2015) Runx2 contributes to the regenerative potential of the mammary epithelium. Scientific Reports, 5, 15658. (doi:10.1038/srep15658) (PMID:26489514) (PMCID:PMC4614940)

2014

Ferrari, N., Mohammed, Z. M. A., Nixon, C., Mason, S. M., Mallon, E., McMillan, D. C. , Morris, J. S. , Cameron, E. R. , Edwards, J. and Blyth, K. (2014) Expression of RUNX1 correlates with poor patient prognosis in triple negative breast cancer. PLoS ONE, 9(6), e100759. (doi:10.1371/journal.pone.0100759) (PMID:24967588) (PMCID:PMC4072705)

McDonald, L. et al. (2014) RUNX2 correlates with subtype-specific breast cancer in a human tissue microarray, and ectopic expression of Runx2 perturbs differentiation in the mouse mammary gland. Disease Models and Mechanisms, 7(5), pp. 525-534. (doi:10.1242/dmm.015040)

Huser, C. A. et al. (2014) Insertional mutagenesis and deep profiling reveals gene hierarchies and a Myc/p53-dependent bottleneck in lymphomagenesis. PLoS Genetics, 10(2), e1004167. (doi:10.1371/journal.pgen.1004167) (PMID:24586197) (PMCID:PMC3937229)

2013

Ferrari, N., McDonald, L., Morris, J.S. , Cameron, E.R. and Blyth, K. (2013) RUNX2 in mammary gland development and breast cancer. Journal of Cellular Physiology, 228(6), pp. 1137-1142. (doi:10.1002/jcp.24285)

2011

Emons, J. et al. (2011) Genome-wide screening in human growth plates during puberty in one patient suggests a role for RUNX2 in epiphyseal maturation. Journal of Endocrinology, 209(2), pp. 245-254. (doi:10.1530/JOE-10-0219)

Cameron, E. (2011) Celebrating 150 years of Glasgow Vet School. Veterinary Record, 169(10), p. 262. (doi:10.1136/vr.d5550)

2010

Blyth, K. , Vaillant, F., Jenkins, A., McDonald, L., Pringle, M. A. , Huser, C. , Stein, T., Neil, J. and Cameron, E. R. (2010) Runx2 in normal tissues and cancer cells: A developing story. Blood Cells, Molecules, and Diseases, 45(2), pp. 117-123. (doi:10.1016/j.bcmd.2010.05.007)

Kilbey, A., Terry, A., Jenkins, A., Borland, G., Zhang, Q.F., Wakelam, M.J.O., Cameron, E.R. and Neil, J.C. (2010) Runx regulation of sphingolipid metabolism and survival signaling. Cancer Research, 70(14), pp. 5860-5869. (doi:10.1158/0008-5472.CAN-10-0726)

2009

Blyth, K. , Slater, N., Hanlon, L., Bell, M., Mackay, N., Stewart, M., Neil, J.C. and Cameron, E.R. (2009) Runx1 promotes B-cell survival and lymphoma development. Blood Cells, Molecules, and Diseases, 43(1), pp. 12-19. (doi:10.1016/j.bcmd.2009.01.013)

Wolyniec, K., Wotton, S., Kilbey, A., Jenkins, A., Terry, A., Peters, G., Stocking, C., Cameron, E.R. and Neil, J.C. (2009) RUNX1 and its fusion oncoprotein derivative, RUNX1-ETO, induce senescence-like growth arrest independently of replicative stress. Oncogene, 28(27), pp. 2502-2512. (doi:10.1038/onc.2009.101)

Scobie, L. et al. (2009) A novel model of SCID-X1 reconstitution reveals predisposition to retrovirus-induced lymphoma but no evidence of gammaC gene oncogenicity. Molecular Therapy, 17(6), pp. 1031-1038. (doi:10.1038/mt.2009.59)

2008

Wotton, S., Terry, A., Kilbey, A., Jenkins, A., Herzyk, P. , Cameron, E. and Neil, J.C. (2008) Gene array analysis reveals a common Runx transcriptional programme controlling cell adhesion and survival. Oncogene, 27(44), pp. 5856-5866. (doi:10.1038/onc.2008.195)

Kilbey, A., Terry, A., Cameron, E.R. and Neil, J.C. (2008) Oncogene-induced senescence: an essential role for Runx. Cell Cycle, 7(15), pp. 2333-2340.

2007

Kilbey, A., Blyth, K. , Wotton, S., Terry, A., Jenkins, A., Bell, M., Hanlon, L., Cameron, E.R. and Neil, J.C. (2007) Runx2 disruption promotes immortalization and confers resistance to oncogene-induced senescence in primary murine fibroblasts. Cancer Research, 67(23), pp. 11263-11271. (doi:10.1158/0008-5472.CAN-07-3016)

Stewart, M., Mackay, N., Hanlon, L., Blyth, K., Scobie, L., Cameron, E. and Neil, J. (2007) Insertional mutagenesis reveals progression genes and checkpoints in MYC/Runx2 lymphomas. Cancer Research, 67, pp. 5126-5133. (doi:10.1158/0008-5472.CAN-07-0433)

2006

Blyth, K., Vaillant, F., Hanlon, L., Mackay, N., Bell, M., Jenkins, A., Neil, J. and Cameron, E. (2006) Runx2 and MYC collaborate in lymphoma development by suppressing apoptotic and growth arrest pathways in vivo. Cancer Research, 66, pp. 2195-2201. (doi:10.1158/0008-5472.CAN-05-3558)

Thrasher, A.J. et al. (2006) Gene therapy: X-SCID transgene leukaemogenicity. Nature, 443(7109), E5-E6. (doi:10.1038/nature05219)

2005

Blyth, K., Cameron, E. and Neil, J. (2005) The RUNX genes: Gain or loss of function in cancer. Nature Reviews Cancer, 5, pp. 376-387. (doi:10.1038/nrc1607)

2004

Cameron, E. and Neil, J. (2004) The Runx genes: lineage-specific oncogenes and tumor suppressors. Oncogene, 23, pp. 4308-4314. (doi:10.1038/sj.onc.1207130)

Terry, A., Kilbey, A., Vaillant, F., Stewart, M., Jenkins, A., Cameron, E. and Neil, J. (2004) Conservation and expression of an alternative 3 ' exon of Runx2 encoding a novel proline-rich C-terminal domain. Gene, 336, pp. 115-125. (doi:10.1016/j.gene.2004.04.015)

Wotton, S., Blyth, K., Kilbey, A., Jenkins, A., Terry, A., Bernardin-Fried, F., Friedman, A., Baxter, E., Neil, J. and Cameron, E. (2004) RUNX1 transformation of primary embryonic fibroblasts is revealed in the absence of p53. Oncogene, 23, pp. 5476-5486. (doi:10.1038/sj.onc.1207729)

2003

Cameron, E. R., Blyth, K. , Hanlon, L., Kilbey, A., Mackay, N., Stewart, M., Terry, A., Vaillant, F., Wotton, S. and Neil, J. C. (2003) The Runx genes as dominant oncogenes. Blood Cells, Molecules, and Diseases, 30, pp. 194-200. (doi:10.1016/S1079-9796(03)00031-7)

Hanlon, L., Barr, N., Blyth, K., Stewart, M., Haviernik, P., Wolff, L., Weston, K., Cameron, E. and Neil, J. (2003) Long-range effects of retroviral insertion on c-myb: Overexpression may be obscured by silencing during tumor growth in vitro. Journal of Virology, 77, pp. 1059-1068. (doi:10.1128/JVI.77.2.1059-1068.2003)

2002

Beatty, J., Terry, A., MacDonald, J., Gault, E., Cevario, S., OBrien, S., Cameron, E. and Neil, J. (2002) Feline immunodeficiency virus integration in B-cell lymphoma identifies a candidate tumor suppressor gene on human chromosome 15q15. Cancer Research, 62, pp. 7175-7180.

Neil, J. and Cameron, E. (2002) Retroviral insertion sites and cancer: Fountain of all knowledge? Cancer Cell, 2, pp. 253-255.

Stewart, M., MacKay, N., Cameron, E. and Neil, J. (2002) The common retroviral insertion locus Dsi1 maps 30 kilobases upstream of the P1 promoter of the murine Runx3/Cbfa3/Aml2 gene. Journal of Virology, 76(9), pp. 4364-4369. (doi:10.1128/JVI.76.9.4364-4369.2002)

Vaillant, F., Blyth, K., Andrew, L., Neil, J. and Cameron, E. (2002) Enforced expression of Runx2 perturbs T cell development at a stage coincident with beta-selection. Journal of Immunology, 169, pp. 2866-2874.

Wotton, S., Stewart, M., Blyth, K., Vaillant, F., Kilbey, A., Neil, J. and Cameron, E. (2002) Proviral insertion indicates a dominant oncogenic role for Runx1/AML-1 in T-cell lymphoma. Cancer Research, 62, pp. 7181-7185.

2001

Ayers, E., Cameron, E. , Kemp, R., Leitch, H., Mollison, A., Muir, I., Reid, H., Smith, D. and Sproat, J. (2001) Oral lesions in sheep and cattle in Dumfries and Galloway. Veterinary Record, 148(23), pp. 720-723. (doi:10.1136/vr.148.23.714)

Baxter, E., Blyth, K., Cameron, E. and Neil, J. (2001) Selection for loss of p53 function in T-cell lymphomagenesis is alleviated by Moloney murine leukemia virus infection in myc transgenic mice. Journal of Virology, 75, pp. 9790-9798.

Blyth, K., Terry, A., Mackay, N., Vaillant, F., Bell, M., Cameron, E., Neil, J. and Stewart, M. (2001) Runx2: A novel oncogenic effector revealed by in vivo complementation and retroviral tagging. Oncogene, 20, pp. 295-302.

2000

Blyth, K. , Stewart, M., Bell, M., James, C., Evan, G., Neil, J. C. and Cameron, E. R. (2000) Sensitivity to myc-induced apoptosis is retained in spontaneous and transplanted lymphomas of CD2-mycERTM mice. Oncogene, 19(6), pp. 773-782. (doi:10.1038/sj.onc.1203321) (PMID:10698495)

Cameron, E.R. , Morton, J. , Johnston, C.J., Irvine, J., Bell, M., Onions, D.E., Neil, J.C. , Campbell, M. and Blyth, K. (2000) Fas-independent apoptosis in T-cell tumours induced by the CD2-myc transgene. Cell Death and Differentiation, 7(1), pp. 80-88. (doi:10.1038/sj.cdd.4400630) (PMID:10713723)

1997

Stewart, M., Terry, A., Hu, M., O'Hara, M., Blyth, K. , Baxter, E., Cameron, E. , Onions, D.E. and Neil, J.C. (1997) Proviral insertions induce the expression of bone-specific isoforms of PEBP2alphaA (CBFA1): evidence for a new myc collaborating oncogene. Proceedings of the National Academy of Sciences of the United States of America, 94(16), pp. 8646-51. (PMID:9238031) (PMCID:PMC23059)

Neil, J. C. , Cameron, E. R. and Baxter, E. W. (1997) p53 and tumour viruses: catching the guardian off-guard. Trends in Microbiology, 5(3), pp. 115-120. (doi:10.1016/S0966-842X(96)10083-4) (PMID:9080610)

1996

Baxter, E.W., Blyth, K. , Donehower, L., Cameron, E.R. , Onions, D.E. and Neil, J.C. (1996) Moloney murine leukemia virus-induced lymphomas in p53-deficient mice: overlapping pathways in tumor development? Journal of Virology, 70(4), pp. 2095-100. (PMID:8642629) (PMCID:PMC190045)

Cameron, E.R. , Campbell, M., Blyth, K. , Argyle, S.A., Keanie, L., Neil, J.C. and Onions, D.E. (1996) Apparent bypass of negative selection in CD8+ tumours in CD2-myc transgenic mice. British Journal of Cancer, 73(1), pp. 13-7. (PMID:8554976) (PMCID:PMC2074291)

This list was generated on Sat Dec 14 20:22:59 2019 GMT.
Number of items: 47.

Articles

Hay, J. , Gilroy, K., Huser, C. , Kilbey, A., Mcdonald, A., MacCallum, A., Holroyd, A. , Cameron, E. and Neil, J. C. (2019) Collaboration of MYC and RUNX2 in lymphoma simulates T‐cell receptor signaling and attenuates p53 pathway activity. Journal of Cellular Biochemistry, 120(10), pp. 18332-18345. (doi:10.1002/jcb.29143) (PMID:31257681) (PMCID:PMC6772115)

Anderson, G. et al. (2018) RUNX-mediated growth arrest and senescence are attenuated by diverse mechanisms in cells expressing RUNX1 fusion oncoproteins. Journal of Cellular Biochemistry, 119(3), pp. 2750-2762. (doi:10.1002/jcb.26443) (PMID:29052866) (PMCID:PMC5813226)

McCarroll, C. S. et al. (2018) Runx1 deficiency protects against adverse cardiac remodeling after myocardial infarction. Circulation, 137(1), pp. 57-70. (doi:10.1161/CIRCULATIONAHA.117.028911) (PMID:29030345) (PMCID:PMC5757664)

Kilbey, A. et al. (2017) Runx1 orchestrates sphingolipid metabolism and glucocorticoid resistance in lymphomagenesis. Journal of Cellular Biochemistry, 118(6), pp. 1432-1441. (doi:10.1002/jcb.25802) (PMID:27869314) (PMCID:5408393)

Terry, A., Kilbey, A., Naseer, A., Levy, L. S., Ahmad, S., Watts, C., Mackay, N., Cameron, E. , Wilson, S. and Neil, J. C. (2017) Barriers to infection of human cells by feline leukemia virus: insights into resistance to zoonosis. Journal of Virology, 91(5), e02119-16. (doi:10.1128/JVI.02119-16) (PMID:28031367) (PMCID:PMC5309941)

Gilroy, K. L. et al. (2016) Gamma-retrovirus integration marks cell type-specific cancer genes: a novel profiling tool in cancer genomics. PLoS ONE, 11(4), e0154070. (doi:10.1371/journal.pone.0154070) (PMID:27097319) (PMCID:PMC4838236)

Borland, G. et al. (2016) Addiction to Runx1 is partially attenuated by loss of p53 in the Eμ-Myc lymphoma model. Oncotarget, 7(17), pp. 22973-22987. (doi:10.18632/oncotarget.8554) (PMID:27056890) (PMCID:PMC5029604)

Naseer, A. et al. (2015) Frequent infection of human cancer xenografts with murine endogenous retroviruses in vivo. Viruses, 7(4), pp. 2014-2029. (doi:10.3390/v7042014) (PMID:25912714) (PMCID:PMC4411688)

Ferrari, N. et al. (2015) Runx2 contributes to the regenerative potential of the mammary epithelium. Scientific Reports, 5, 15658. (doi:10.1038/srep15658) (PMID:26489514) (PMCID:PMC4614940)

Ferrari, N., Mohammed, Z. M. A., Nixon, C., Mason, S. M., Mallon, E., McMillan, D. C. , Morris, J. S. , Cameron, E. R. , Edwards, J. and Blyth, K. (2014) Expression of RUNX1 correlates with poor patient prognosis in triple negative breast cancer. PLoS ONE, 9(6), e100759. (doi:10.1371/journal.pone.0100759) (PMID:24967588) (PMCID:PMC4072705)

McDonald, L. et al. (2014) RUNX2 correlates with subtype-specific breast cancer in a human tissue microarray, and ectopic expression of Runx2 perturbs differentiation in the mouse mammary gland. Disease Models and Mechanisms, 7(5), pp. 525-534. (doi:10.1242/dmm.015040)

Huser, C. A. et al. (2014) Insertional mutagenesis and deep profiling reveals gene hierarchies and a Myc/p53-dependent bottleneck in lymphomagenesis. PLoS Genetics, 10(2), e1004167. (doi:10.1371/journal.pgen.1004167) (PMID:24586197) (PMCID:PMC3937229)

Ferrari, N., McDonald, L., Morris, J.S. , Cameron, E.R. and Blyth, K. (2013) RUNX2 in mammary gland development and breast cancer. Journal of Cellular Physiology, 228(6), pp. 1137-1142. (doi:10.1002/jcp.24285)

Emons, J. et al. (2011) Genome-wide screening in human growth plates during puberty in one patient suggests a role for RUNX2 in epiphyseal maturation. Journal of Endocrinology, 209(2), pp. 245-254. (doi:10.1530/JOE-10-0219)

Cameron, E. (2011) Celebrating 150 years of Glasgow Vet School. Veterinary Record, 169(10), p. 262. (doi:10.1136/vr.d5550)

Blyth, K. , Vaillant, F., Jenkins, A., McDonald, L., Pringle, M. A. , Huser, C. , Stein, T., Neil, J. and Cameron, E. R. (2010) Runx2 in normal tissues and cancer cells: A developing story. Blood Cells, Molecules, and Diseases, 45(2), pp. 117-123. (doi:10.1016/j.bcmd.2010.05.007)

Kilbey, A., Terry, A., Jenkins, A., Borland, G., Zhang, Q.F., Wakelam, M.J.O., Cameron, E.R. and Neil, J.C. (2010) Runx regulation of sphingolipid metabolism and survival signaling. Cancer Research, 70(14), pp. 5860-5869. (doi:10.1158/0008-5472.CAN-10-0726)

Blyth, K. , Slater, N., Hanlon, L., Bell, M., Mackay, N., Stewart, M., Neil, J.C. and Cameron, E.R. (2009) Runx1 promotes B-cell survival and lymphoma development. Blood Cells, Molecules, and Diseases, 43(1), pp. 12-19. (doi:10.1016/j.bcmd.2009.01.013)

Wolyniec, K., Wotton, S., Kilbey, A., Jenkins, A., Terry, A., Peters, G., Stocking, C., Cameron, E.R. and Neil, J.C. (2009) RUNX1 and its fusion oncoprotein derivative, RUNX1-ETO, induce senescence-like growth arrest independently of replicative stress. Oncogene, 28(27), pp. 2502-2512. (doi:10.1038/onc.2009.101)

Scobie, L. et al. (2009) A novel model of SCID-X1 reconstitution reveals predisposition to retrovirus-induced lymphoma but no evidence of gammaC gene oncogenicity. Molecular Therapy, 17(6), pp. 1031-1038. (doi:10.1038/mt.2009.59)

Wotton, S., Terry, A., Kilbey, A., Jenkins, A., Herzyk, P. , Cameron, E. and Neil, J.C. (2008) Gene array analysis reveals a common Runx transcriptional programme controlling cell adhesion and survival. Oncogene, 27(44), pp. 5856-5866. (doi:10.1038/onc.2008.195)

Kilbey, A., Terry, A., Cameron, E.R. and Neil, J.C. (2008) Oncogene-induced senescence: an essential role for Runx. Cell Cycle, 7(15), pp. 2333-2340.

Kilbey, A., Blyth, K. , Wotton, S., Terry, A., Jenkins, A., Bell, M., Hanlon, L., Cameron, E.R. and Neil, J.C. (2007) Runx2 disruption promotes immortalization and confers resistance to oncogene-induced senescence in primary murine fibroblasts. Cancer Research, 67(23), pp. 11263-11271. (doi:10.1158/0008-5472.CAN-07-3016)

Stewart, M., Mackay, N., Hanlon, L., Blyth, K., Scobie, L., Cameron, E. and Neil, J. (2007) Insertional mutagenesis reveals progression genes and checkpoints in MYC/Runx2 lymphomas. Cancer Research, 67, pp. 5126-5133. (doi:10.1158/0008-5472.CAN-07-0433)

Blyth, K., Vaillant, F., Hanlon, L., Mackay, N., Bell, M., Jenkins, A., Neil, J. and Cameron, E. (2006) Runx2 and MYC collaborate in lymphoma development by suppressing apoptotic and growth arrest pathways in vivo. Cancer Research, 66, pp. 2195-2201. (doi:10.1158/0008-5472.CAN-05-3558)

Thrasher, A.J. et al. (2006) Gene therapy: X-SCID transgene leukaemogenicity. Nature, 443(7109), E5-E6. (doi:10.1038/nature05219)

Blyth, K., Cameron, E. and Neil, J. (2005) The RUNX genes: Gain or loss of function in cancer. Nature Reviews Cancer, 5, pp. 376-387. (doi:10.1038/nrc1607)

Cameron, E. and Neil, J. (2004) The Runx genes: lineage-specific oncogenes and tumor suppressors. Oncogene, 23, pp. 4308-4314. (doi:10.1038/sj.onc.1207130)

Terry, A., Kilbey, A., Vaillant, F., Stewart, M., Jenkins, A., Cameron, E. and Neil, J. (2004) Conservation and expression of an alternative 3 ' exon of Runx2 encoding a novel proline-rich C-terminal domain. Gene, 336, pp. 115-125. (doi:10.1016/j.gene.2004.04.015)

Wotton, S., Blyth, K., Kilbey, A., Jenkins, A., Terry, A., Bernardin-Fried, F., Friedman, A., Baxter, E., Neil, J. and Cameron, E. (2004) RUNX1 transformation of primary embryonic fibroblasts is revealed in the absence of p53. Oncogene, 23, pp. 5476-5486. (doi:10.1038/sj.onc.1207729)

Cameron, E. R., Blyth, K. , Hanlon, L., Kilbey, A., Mackay, N., Stewart, M., Terry, A., Vaillant, F., Wotton, S. and Neil, J. C. (2003) The Runx genes as dominant oncogenes. Blood Cells, Molecules, and Diseases, 30, pp. 194-200. (doi:10.1016/S1079-9796(03)00031-7)

Hanlon, L., Barr, N., Blyth, K., Stewart, M., Haviernik, P., Wolff, L., Weston, K., Cameron, E. and Neil, J. (2003) Long-range effects of retroviral insertion on c-myb: Overexpression may be obscured by silencing during tumor growth in vitro. Journal of Virology, 77, pp. 1059-1068. (doi:10.1128/JVI.77.2.1059-1068.2003)

Beatty, J., Terry, A., MacDonald, J., Gault, E., Cevario, S., OBrien, S., Cameron, E. and Neil, J. (2002) Feline immunodeficiency virus integration in B-cell lymphoma identifies a candidate tumor suppressor gene on human chromosome 15q15. Cancer Research, 62, pp. 7175-7180.

Neil, J. and Cameron, E. (2002) Retroviral insertion sites and cancer: Fountain of all knowledge? Cancer Cell, 2, pp. 253-255.

Stewart, M., MacKay, N., Cameron, E. and Neil, J. (2002) The common retroviral insertion locus Dsi1 maps 30 kilobases upstream of the P1 promoter of the murine Runx3/Cbfa3/Aml2 gene. Journal of Virology, 76(9), pp. 4364-4369. (doi:10.1128/JVI.76.9.4364-4369.2002)

Vaillant, F., Blyth, K., Andrew, L., Neil, J. and Cameron, E. (2002) Enforced expression of Runx2 perturbs T cell development at a stage coincident with beta-selection. Journal of Immunology, 169, pp. 2866-2874.

Wotton, S., Stewart, M., Blyth, K., Vaillant, F., Kilbey, A., Neil, J. and Cameron, E. (2002) Proviral insertion indicates a dominant oncogenic role for Runx1/AML-1 in T-cell lymphoma. Cancer Research, 62, pp. 7181-7185.

Ayers, E., Cameron, E. , Kemp, R., Leitch, H., Mollison, A., Muir, I., Reid, H., Smith, D. and Sproat, J. (2001) Oral lesions in sheep and cattle in Dumfries and Galloway. Veterinary Record, 148(23), pp. 720-723. (doi:10.1136/vr.148.23.714)

Baxter, E., Blyth, K., Cameron, E. and Neil, J. (2001) Selection for loss of p53 function in T-cell lymphomagenesis is alleviated by Moloney murine leukemia virus infection in myc transgenic mice. Journal of Virology, 75, pp. 9790-9798.

Blyth, K., Terry, A., Mackay, N., Vaillant, F., Bell, M., Cameron, E., Neil, J. and Stewart, M. (2001) Runx2: A novel oncogenic effector revealed by in vivo complementation and retroviral tagging. Oncogene, 20, pp. 295-302.

Blyth, K. , Stewart, M., Bell, M., James, C., Evan, G., Neil, J. C. and Cameron, E. R. (2000) Sensitivity to myc-induced apoptosis is retained in spontaneous and transplanted lymphomas of CD2-mycERTM mice. Oncogene, 19(6), pp. 773-782. (doi:10.1038/sj.onc.1203321) (PMID:10698495)

Cameron, E.R. , Morton, J. , Johnston, C.J., Irvine, J., Bell, M., Onions, D.E., Neil, J.C. , Campbell, M. and Blyth, K. (2000) Fas-independent apoptosis in T-cell tumours induced by the CD2-myc transgene. Cell Death and Differentiation, 7(1), pp. 80-88. (doi:10.1038/sj.cdd.4400630) (PMID:10713723)

Stewart, M., Terry, A., Hu, M., O'Hara, M., Blyth, K. , Baxter, E., Cameron, E. , Onions, D.E. and Neil, J.C. (1997) Proviral insertions induce the expression of bone-specific isoforms of PEBP2alphaA (CBFA1): evidence for a new myc collaborating oncogene. Proceedings of the National Academy of Sciences of the United States of America, 94(16), pp. 8646-51. (PMID:9238031) (PMCID:PMC23059)

Neil, J. C. , Cameron, E. R. and Baxter, E. W. (1997) p53 and tumour viruses: catching the guardian off-guard. Trends in Microbiology, 5(3), pp. 115-120. (doi:10.1016/S0966-842X(96)10083-4) (PMID:9080610)

Baxter, E.W., Blyth, K. , Donehower, L., Cameron, E.R. , Onions, D.E. and Neil, J.C. (1996) Moloney murine leukemia virus-induced lymphomas in p53-deficient mice: overlapping pathways in tumor development? Journal of Virology, 70(4), pp. 2095-100. (PMID:8642629) (PMCID:PMC190045)

Cameron, E.R. , Campbell, M., Blyth, K. , Argyle, S.A., Keanie, L., Neil, J.C. and Onions, D.E. (1996) Apparent bypass of negative selection in CD8+ tumours in CD2-myc transgenic mice. British Journal of Cancer, 73(1), pp. 13-7. (PMID:8554976) (PMCID:PMC2074291)

Book Sections

Rooney, N., Riggio, A. I., Mendoza-Villanueva, D., Shore, P., Cameron, E. R. and Blyth, K. (2017) Runx genes in breast cancer and the mammary lineage. In: Groner, Y., Ito, Y., Liu, P., Neil, J. C., Speck, N. A. and van Wijnen, A. (eds.) RUNX Proteins in Development and Cancer. Series: Advances in experimental medicine and biology, 96 (962). Springer, pp. 353-368. ISBN 9789811032318 (doi:10.1007/978-981-10-3233-2_22)

This list was generated on Sat Dec 14 20:22:59 2019 GMT.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Investigating the Therapeutic Potential of Runx1 for Myocardial Infarction
    British Heart Foundation
    2018 - 2021
     
  • INSPIRE Award
    Academy of Medical Sciences
    2016 - 2017
     
  • INVESTIGATING THE ROLE OF RUNX1 IN THE HEART POST-MYOCARDIAL INFARCTION
    Medical Research Council
    2015 - 2018
     
  • New Approaches to Modelling Human Leukaemia
    Bloodwise
    2011 - 2017
     
  • New Approaches to Modelling Human Leukaemia
    Cancer Research UK
    2011 - 2016
     
  • Centre for Virus Research
    Medical Research Council
    2010 - 2016
     
  • Centre for Integrated Virology
    Medical Research Council
    2010 - 2015
     
  • Investigating the expression and function of RUNX1 in cardiac tissue during myocardial infarction
    British Heart Foundation
    2009 - 2011
     
  • The role of the runx gene family in neoplasia
    Cancer Research UK
    2009 - 2010
     
  • The role of Runx2 in mammary development and breast cancer
    Association for International Cancer Research
    2008 - 2008
     
  • The Genetics and Biology of t-cell Lymphoma
    Cancer Research UK
    2004 - 2005