Dr Sakharam Waghmare

  • Research Associate (Molecular Biosciences)

telephone: 01413302381
email: Sakharam.Waghmare@glasgow.ac.uk

Stevenson Lab, Institute of MC&SB, Bower Building

Import to contacts

ORCID iDhttps://orcid.org/0000-0003-1918-0673

Biography

Sak comes from a background in the pharmaceutical-biotechnology industry and doctoral training in chemical and biological engineering. He has a PhD in Chemical Engineering from the University of Sheffield, where he developed and utilised RNA HPLC and quantitative RNA-mass spectrometry to study crRNA biogenesis in CRISPR/Cas complex in different bacterial systems.
Sak moved to the plant science lab at the University of Glasgow (2013) and has since perused research to address transport protein complexes underpinning plant environment sensing. In addition to his scientific work, he contributes to Plant Science public engagement initiatives through two cross-disciplinary STEM projects, StomaToy and Sci-Seedlets, to enhance plant science awareness in communities and school children.

Research interests

Plants have evolved a complex membrane traffic system that utilises membrane vesicles to facilitate intracellular transport, protein recycling, and secretion of signalling molecules for growth and defence. I study the underpinning molecular mechanisms of this system through multi-disciplinary approaches, including cell biology, protein biochemistry, mass spectrometry, structural biology, and plant physiology.

Currently, I am investigating 1) SNARE-dependent secretory pathways and their significance in environmental stresses and evolution, and 2) endolysosomal dynamics and their impact on phytohormones and CO2 response.

 

Publications

List by: Type | Date

Jump to: 2024 | 2022 | 2019 | 2018 | 2017 | 2015
Number of items: 11.

2024

Waghmare, S. , Xia, L. , Phan Ly, T., Xu, J., Farami, S., Burchmore, R. , Blatt, M. R. and Karnik, R. (2024) SYNTAXIN OF PLANTS 132 underpins secretion of cargoes associated with salicylic acid signaling and pathogen defense. Plant Physiology, (doi: 10.1093/plphys/kiae541) (In Press)

Baena, G. , Xia, L. , Waghmare, S. , Yu, Z., Guo, Y., Blatt, M. R. , Zhang, B. and Karnik, R. (2024) Arabidopsis SNARE SYP132 impacts on PIP2;1 trafficking and function in salinity stress. Plant Journal, 118(4), pp. 1036-1053. (doi: 10.1111/tpj.16649) (PMID:38289468)

2022

Horaruang, W. et al. (2022) Engineering a K+ channel 'sensory antenna' enhances stomatal kinetics, water use efficiency and photosynthesis. Nature Plants, 8(11), pp. 1262-1274. (doi: 10.1038/s41477-022-01255-2) (PMID:36266492)

Baena, G. , Xia, L. , Waghmare, S. and Karnik, R. (2022) SNARE SYP132 mediates divergent trafficking of H+-ATPase AHA1 and antimicrobial PR1 during bacterial pathogenesis. Plant Physiology, 189(3), pp. 1639-1661. (doi: 10.1093/plphys/kiac149) (PMID:35348763) (PMCID:PMC9237740)

2019

Waghmare, S. , Lefoulon, C., Zhang, B. , Lileikyte, E., Donald, N. and Blatt, M. (2019) K+ channel and SEC11 binding exchange regulates SNARE assembly for secretory traffic. Plant Physiology, 181, pp. 1096-1113. (doi: 10.1104/pp.19.00919) (PMID:31548266)

2018

Waghmare, S. , Lileikyte, E., Karnik, R. , Goodman, J. K., Blatt, M. R. and Jones, A. M.E. (2018) SNAREs SYP121 and SYP122 mediate the secretion of distinct cargo subsets. Plant Physiology, 178(4), pp. 1679-1688. (doi: 10.1104/pp.18.00832) (PMID:30348815)

Lefoulon, C., Waghmare, S. , Karnik, R. and Blatt, M. R. (2018) Gating control and K+ uptake by the KAT1 K+ channel leaveraged through membrane anchoring of the trafficking protein SYP121. Plant, Cell and Environment, 41(11), pp. 2668-2677. (doi: 10.1111/pce.13392) (PMID:29940699) (PMCID:PMC6220998)

2017

Karnik, R. , Waghmare, S. , Zhang, B. , Larson, E., Lefoulon, C., Gonzalez, W. and Blatt, M. R. (2017) Commandeering channel voltage sensors for secretion, cell turgor, and volume control. Trends in Plant Science, 22(1), pp. 81-95. (doi: 10.1016/j.tplants.2016.10.006) (PMID:27818003) (PMCID:PMC5224186)

Zhang, B. , Karnik, R. , Waghmare, S. , Donald, N. A. and Blatt, M. R. (2017) VAMP721 conformations unmask an extended motif for K+ channel binding and gating control. Plant Physiology, 173(1), pp. 536-551. (doi: 10.1104/pp.16.01549) (PMID:27821719)

2015

Grefen, C., Karnik, R. , Larson, E., Lefoulon, C., Wang, Y., Waghmare, S. , Zhang, B. , Hills, A. and Blatt, M. R. (2015) A vesicle-trafficking protein commandeers Kv channel voltage sensors for voltage-dependent secretion. Nature Plants, 1, 15108. (doi: 10.1038/nplants.2015.108)

Karnik, R. , Zhang, B. , Waghmare, S. , Aderhold, C., Grefen, C. and Blatt, M. R. (2015) Binding of SEC11 indicates its role in SNARE recycling after vesicle fusion and identifies two pathways for vesicular traffic to the plasma membrane. Plant Cell, 27(3), pp. 675-694. (doi: 10.1105/tpc.114.134429) (PMID:25747882)

This list was generated on Wed Apr 30 21:13:03 2025 BST.
Jump to: Articles
Number of items: 11.

Articles

Waghmare, S. , Xia, L. , Phan Ly, T., Xu, J., Farami, S., Burchmore, R. , Blatt, M. R. and Karnik, R. (2024) SYNTAXIN OF PLANTS 132 underpins secretion of cargoes associated with salicylic acid signaling and pathogen defense. Plant Physiology, (doi: 10.1093/plphys/kiae541) (In Press)

Baena, G. , Xia, L. , Waghmare, S. , Yu, Z., Guo, Y., Blatt, M. R. , Zhang, B. and Karnik, R. (2024) Arabidopsis SNARE SYP132 impacts on PIP2;1 trafficking and function in salinity stress. Plant Journal, 118(4), pp. 1036-1053. (doi: 10.1111/tpj.16649) (PMID:38289468)

Horaruang, W. et al. (2022) Engineering a K+ channel 'sensory antenna' enhances stomatal kinetics, water use efficiency and photosynthesis. Nature Plants, 8(11), pp. 1262-1274. (doi: 10.1038/s41477-022-01255-2) (PMID:36266492)

Baena, G. , Xia, L. , Waghmare, S. and Karnik, R. (2022) SNARE SYP132 mediates divergent trafficking of H+-ATPase AHA1 and antimicrobial PR1 during bacterial pathogenesis. Plant Physiology, 189(3), pp. 1639-1661. (doi: 10.1093/plphys/kiac149) (PMID:35348763) (PMCID:PMC9237740)

Waghmare, S. , Lefoulon, C., Zhang, B. , Lileikyte, E., Donald, N. and Blatt, M. (2019) K+ channel and SEC11 binding exchange regulates SNARE assembly for secretory traffic. Plant Physiology, 181, pp. 1096-1113. (doi: 10.1104/pp.19.00919) (PMID:31548266)

Waghmare, S. , Lileikyte, E., Karnik, R. , Goodman, J. K., Blatt, M. R. and Jones, A. M.E. (2018) SNAREs SYP121 and SYP122 mediate the secretion of distinct cargo subsets. Plant Physiology, 178(4), pp. 1679-1688. (doi: 10.1104/pp.18.00832) (PMID:30348815)

Lefoulon, C., Waghmare, S. , Karnik, R. and Blatt, M. R. (2018) Gating control and K+ uptake by the KAT1 K+ channel leaveraged through membrane anchoring of the trafficking protein SYP121. Plant, Cell and Environment, 41(11), pp. 2668-2677. (doi: 10.1111/pce.13392) (PMID:29940699) (PMCID:PMC6220998)

Karnik, R. , Waghmare, S. , Zhang, B. , Larson, E., Lefoulon, C., Gonzalez, W. and Blatt, M. R. (2017) Commandeering channel voltage sensors for secretion, cell turgor, and volume control. Trends in Plant Science, 22(1), pp. 81-95. (doi: 10.1016/j.tplants.2016.10.006) (PMID:27818003) (PMCID:PMC5224186)

Zhang, B. , Karnik, R. , Waghmare, S. , Donald, N. A. and Blatt, M. R. (2017) VAMP721 conformations unmask an extended motif for K+ channel binding and gating control. Plant Physiology, 173(1), pp. 536-551. (doi: 10.1104/pp.16.01549) (PMID:27821719)

Grefen, C., Karnik, R. , Larson, E., Lefoulon, C., Wang, Y., Waghmare, S. , Zhang, B. , Hills, A. and Blatt, M. R. (2015) A vesicle-trafficking protein commandeers Kv channel voltage sensors for voltage-dependent secretion. Nature Plants, 1, 15108. (doi: 10.1038/nplants.2015.108)

Karnik, R. , Zhang, B. , Waghmare, S. , Aderhold, C., Grefen, C. and Blatt, M. R. (2015) Binding of SEC11 indicates its role in SNARE recycling after vesicle fusion and identifies two pathways for vesicular traffic to the plasma membrane. Plant Cell, 27(3), pp. 675-694. (doi: 10.1105/tpc.114.134429) (PMID:25747882)

This list was generated on Wed Apr 30 21:13:03 2025 BST.