Dr Karen McLuskey

  • Research Associate (Molecular Biosciences)

telephone: 8117
email: Karen.McLuskey@glasgow.ac.uk

Davidson Building

Import to contacts

Publications

List by: Type | Date

Jump to: 2024 | 2021 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2008
Number of items: 14.

2024

Myburgh, Elmarie, Geoghegan, Vincent, Alves-Ferreira, Eliza V.C., Nievas, Y. Romina, Grewal, Jaspreet S., Brown, Elaine, McLuskey, Karen and Mottram, Jeremy C. (2024) TORC1 is an essential regulator of nutrient-controlled proliferation and differentiation in Leishmania. EMBO Reports, 25(3), pp. 1075-1105. (doi: 10.1038/s44319-024-00084-y) (PMID:38396206) (PMCID:PMC10933368)

2021

McLuskey, Karen, Wandy, Joe ORCID logoORCID: https://orcid.org/0000-0002-3068-4664, Vincent, Isabel ORCID logoORCID: https://orcid.org/0000-0003-2663-4389, Van Der Hooft, Justin J.J. ORCID logoORCID: https://orcid.org/0000-0002-9340-5511, Rogers, Simon ORCID logoORCID: https://orcid.org/0000-0003-3578-4477, Burgess, Karl and Daly, Ronan ORCID logoORCID: https://orcid.org/0000-0002-1275-6820 (2021) Ranking metabolite sets by their activity levels. Metabolites, 11(2), 103. (doi: 10.3390/metabo11020103) (PMID:33670102) (PMCID:PMC7916825)

2016

Grewal, J. S. et al. (2016) PNT1 is a C11 cysteine peptidase essential for replication of the trypanosome kinetoplast. Journal of Biological Chemistry, 291, pp. 9492-9500. (doi: 10.1074/jbc.M116.714972) (PMID:26940875) (PMCID:PMC4850289)

McLuskey, Karen, Grewal, Jaspreet S., Das, Debanu, Godzik, Adam, Lesley, Scott A., Deacon, Ashley M., Coombs, Graham H., Elsliger, Marc-André, Wilson, Ian A. and Mottram, Jeremy C. ORCID logoORCID: https://orcid.org/0000-0001-5574-3766 (2016) Crystal structure and activity studies of the C11 cysteine peptidase from Parabacteroides merdae in the human gut microbiome. Journal of Biological Chemistry, 291, pp. 9482-9491. (doi: 10.1074/jbc.M115.706143) (PMID:26940874) (PMCID:PMC4850288)

2015

McLuskey, Karen and Mottram, Jeremy C. ORCID logoORCID: https://orcid.org/0000-0001-5574-3766 (2015) Comparative structural analysis of the caspase family with other clan CD cysteine peptidases. Biochemical Journal, 466(2), pp. 219-232. (doi: 10.1042/BJ20141324) (PMID:25697094) (PMCID:PMC4357240)

2014

McLuskey, Karen, Moss, Catherine X. and Mottram, Jeremy C. ORCID logoORCID: https://orcid.org/0000-0001-5574-3766 (2014) Purification, characterization, and crystallization of trypanosoma metacaspases. Methods in Molecular Biology, 1133, pp. 203-221. (doi: 10.1007/978-1-4939-0357-3_13)

2013

Machado, M.K.M, Marcondes, M.F., Juliano, M.A., McLuskey, K., Mottram, J.C. ORCID logoORCID: https://orcid.org/0000-0001-5574-3766, Moss, C.X., Juliano, L. and Oliveira, V. (2013) Substrate specificity and the effect of calcium on Trypanosomabrucei metacaspase 2. FEBS Journal, 280(11), pp. 2608-2621. (doi: 10.1111/febs.12248)

Gabrielsen, M. ORCID logoORCID: https://orcid.org/0000-0002-9848-2276, Roe, A.J. ORCID logoORCID: https://orcid.org/0000-0003-3698-6134 and McLuskey, K. (2013) High-throughput methods for the detection of protein overexpression using fluorescence markers. Methods in Cell Biology, 113, pp. 189-208. (doi: 10.1016/B978-0-12-407239-8.00010-0)

2012

McLuskey, Karen, Rudolf, Jana, Proto, William R., Isaacs, Neil W., Coombs, Graham H., Moss, Catherine X. and Mottram, Jeremy C. ORCID logoORCID: https://orcid.org/0000-0001-5574-3766 (2012) Crystal structure of a Trypanosoma brucei metacaspase. Proceedings of the National Academy of Sciences of the United States of America, 109(19), pp. 7469-7474. (doi: 10.1073/pnas.1200885109)

2011

Gabrielsen, M. ORCID logoORCID: https://orcid.org/0000-0002-9848-2276, Kroner, F., Black, I., Isaacs, N.W., Roe, A.J. ORCID logoORCID: https://orcid.org/0000-0003-3698-6134 and McLuskey, K. (2011) High-throughput identification of purification conditions leads to preliminary crystallization conditions for three inner membrane proteins. Molecular Membrane Biology, 28(7-8), pp. 445-453. (doi: 10.3109/09687688.2011.628954) (PMID:22034843)

Munday, Jane C. ORCID logoORCID: https://orcid.org/0000-0001-7792-2749, McLuskey, Karen, Brown, Elaine, Coombs, Graham H. and Mottram, Jeremy C. ORCID logoORCID: https://orcid.org/0000-0001-5574-3766 (2011) Oligopeptidase B deficient mutants of Leishmania major. Molecular and Biochemical Parasitology, 175(1), pp. 49-57. (doi: 10.1016/j.molbiopara.2010.09.003)

2010

McLuskey, Karen, Paterson, Neil G., Bland, Nicholas D., Isaacs, Neil W. and Mottram, Jeremy C. ORCID logoORCID: https://orcid.org/0000-0001-5574-3766 (2010) Crystal structure of leishmania major oligopeptidase B gives insight into the enzymatic properties of a trypanosomatid virulence factor. Journal of Biological Chemistry, 285(50), pp. 39249-39259. (doi: 10.1074/jbc.M110.156679)

McLuskey, K., Roszak, A. W., Zhu, Y. S. and Isaacs, N. W. (2010) Crystal structures of all-alpha type membrane proteins. European Biophysics Journal with Biophysics Letters, 39(5), pp. 723-755. (doi: 10.1007/s00249-009-0546-6)

2008

McLuskey, K., Gabrielsen, M. ORCID logoORCID: https://orcid.org/0000-0002-9848-2276, Kroner, Frank, Black, I., Cogdell, R.J. ORCID logoORCID: https://orcid.org/0000-0003-2119-6607 and Isaacs, N.W. (2008) A protocol for high throughput methods for the expression and purification of inner membrane proteins. Molecular Membrane Biology, 25(8), pp. 599-608. (doi: 10.1080/09687680802510289)

This list was generated on Sun Jun 15 03:43:24 2025 BST.
Jump to: Articles
Number of items: 14.

Articles

Myburgh, Elmarie, Geoghegan, Vincent, Alves-Ferreira, Eliza V.C., Nievas, Y. Romina, Grewal, Jaspreet S., Brown, Elaine, McLuskey, Karen and Mottram, Jeremy C. (2024) TORC1 is an essential regulator of nutrient-controlled proliferation and differentiation in Leishmania. EMBO Reports, 25(3), pp. 1075-1105. (doi: 10.1038/s44319-024-00084-y) (PMID:38396206) (PMCID:PMC10933368)

McLuskey, Karen, Wandy, Joe ORCID logoORCID: https://orcid.org/0000-0002-3068-4664, Vincent, Isabel ORCID logoORCID: https://orcid.org/0000-0003-2663-4389, Van Der Hooft, Justin J.J. ORCID logoORCID: https://orcid.org/0000-0002-9340-5511, Rogers, Simon ORCID logoORCID: https://orcid.org/0000-0003-3578-4477, Burgess, Karl and Daly, Ronan ORCID logoORCID: https://orcid.org/0000-0002-1275-6820 (2021) Ranking metabolite sets by their activity levels. Metabolites, 11(2), 103. (doi: 10.3390/metabo11020103) (PMID:33670102) (PMCID:PMC7916825)

Grewal, J. S. et al. (2016) PNT1 is a C11 cysteine peptidase essential for replication of the trypanosome kinetoplast. Journal of Biological Chemistry, 291, pp. 9492-9500. (doi: 10.1074/jbc.M116.714972) (PMID:26940875) (PMCID:PMC4850289)

McLuskey, Karen, Grewal, Jaspreet S., Das, Debanu, Godzik, Adam, Lesley, Scott A., Deacon, Ashley M., Coombs, Graham H., Elsliger, Marc-André, Wilson, Ian A. and Mottram, Jeremy C. ORCID logoORCID: https://orcid.org/0000-0001-5574-3766 (2016) Crystal structure and activity studies of the C11 cysteine peptidase from Parabacteroides merdae in the human gut microbiome. Journal of Biological Chemistry, 291, pp. 9482-9491. (doi: 10.1074/jbc.M115.706143) (PMID:26940874) (PMCID:PMC4850288)

McLuskey, Karen and Mottram, Jeremy C. ORCID logoORCID: https://orcid.org/0000-0001-5574-3766 (2015) Comparative structural analysis of the caspase family with other clan CD cysteine peptidases. Biochemical Journal, 466(2), pp. 219-232. (doi: 10.1042/BJ20141324) (PMID:25697094) (PMCID:PMC4357240)

McLuskey, Karen, Moss, Catherine X. and Mottram, Jeremy C. ORCID logoORCID: https://orcid.org/0000-0001-5574-3766 (2014) Purification, characterization, and crystallization of trypanosoma metacaspases. Methods in Molecular Biology, 1133, pp. 203-221. (doi: 10.1007/978-1-4939-0357-3_13)

Machado, M.K.M, Marcondes, M.F., Juliano, M.A., McLuskey, K., Mottram, J.C. ORCID logoORCID: https://orcid.org/0000-0001-5574-3766, Moss, C.X., Juliano, L. and Oliveira, V. (2013) Substrate specificity and the effect of calcium on Trypanosomabrucei metacaspase 2. FEBS Journal, 280(11), pp. 2608-2621. (doi: 10.1111/febs.12248)

Gabrielsen, M. ORCID logoORCID: https://orcid.org/0000-0002-9848-2276, Roe, A.J. ORCID logoORCID: https://orcid.org/0000-0003-3698-6134 and McLuskey, K. (2013) High-throughput methods for the detection of protein overexpression using fluorescence markers. Methods in Cell Biology, 113, pp. 189-208. (doi: 10.1016/B978-0-12-407239-8.00010-0)

McLuskey, Karen, Rudolf, Jana, Proto, William R., Isaacs, Neil W., Coombs, Graham H., Moss, Catherine X. and Mottram, Jeremy C. ORCID logoORCID: https://orcid.org/0000-0001-5574-3766 (2012) Crystal structure of a Trypanosoma brucei metacaspase. Proceedings of the National Academy of Sciences of the United States of America, 109(19), pp. 7469-7474. (doi: 10.1073/pnas.1200885109)

Gabrielsen, M. ORCID logoORCID: https://orcid.org/0000-0002-9848-2276, Kroner, F., Black, I., Isaacs, N.W., Roe, A.J. ORCID logoORCID: https://orcid.org/0000-0003-3698-6134 and McLuskey, K. (2011) High-throughput identification of purification conditions leads to preliminary crystallization conditions for three inner membrane proteins. Molecular Membrane Biology, 28(7-8), pp. 445-453. (doi: 10.3109/09687688.2011.628954) (PMID:22034843)

Munday, Jane C. ORCID logoORCID: https://orcid.org/0000-0001-7792-2749, McLuskey, Karen, Brown, Elaine, Coombs, Graham H. and Mottram, Jeremy C. ORCID logoORCID: https://orcid.org/0000-0001-5574-3766 (2011) Oligopeptidase B deficient mutants of Leishmania major. Molecular and Biochemical Parasitology, 175(1), pp. 49-57. (doi: 10.1016/j.molbiopara.2010.09.003)

McLuskey, Karen, Paterson, Neil G., Bland, Nicholas D., Isaacs, Neil W. and Mottram, Jeremy C. ORCID logoORCID: https://orcid.org/0000-0001-5574-3766 (2010) Crystal structure of leishmania major oligopeptidase B gives insight into the enzymatic properties of a trypanosomatid virulence factor. Journal of Biological Chemistry, 285(50), pp. 39249-39259. (doi: 10.1074/jbc.M110.156679)

McLuskey, K., Roszak, A. W., Zhu, Y. S. and Isaacs, N. W. (2010) Crystal structures of all-alpha type membrane proteins. European Biophysics Journal with Biophysics Letters, 39(5), pp. 723-755. (doi: 10.1007/s00249-009-0546-6)

McLuskey, K., Gabrielsen, M. ORCID logoORCID: https://orcid.org/0000-0002-9848-2276, Kroner, Frank, Black, I., Cogdell, R.J. ORCID logoORCID: https://orcid.org/0000-0003-2119-6607 and Isaacs, N.W. (2008) A protocol for high throughput methods for the expression and purification of inner membrane proteins. Molecular Membrane Biology, 25(8), pp. 599-608. (doi: 10.1080/09687680802510289)

This list was generated on Sun Jun 15 03:43:24 2025 BST.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Structure and activity of trypanosomatid metacaspases
    Wellcome Trust
    2010 - 2014