Dr David Leader
- Honorary Senior Reseach Fellow (School of Molecular Biosciences)
email:
David.Leader@glasgow.ac.uk
Room 919, Boyd Orr Building, Glasgow, G12 8QQ
Publications
2024
Leader, David P. ORCID: https://orcid.org/0000-0002-0635-1843, Naseem, Muhammad T. and Halberg, Kenneth V.
(2024)
BeetleAtlas: an ontogenetic and tissue-specific transcriptomic atlas of the red flour beetle Tribolium castaneum.
Journal of Molecular Biology, 436(17),
168520.
(doi: 10.1016/j.jmb.2024.168520)
Leader, David P. ORCID: https://orcid.org/0000-0002-0635-1843
(2024)
E. James Milner-White (1945–2023).
Proteins: Structure Function and Bioinformatics, 92(6),
pp. 691-692.
(doi: 10.1002/prot.26664)
(PMID:38197126)
Leader, David P. ORCID: https://orcid.org/0000-0002-0635-1843 and Coggins, John R.
(2024)
E. James Milner-White, 1945–2023.
Biochemist, 46(1),
pp. 34-35.
(doi: 10.1042/bio_2024_108)
2023
Naseem, Muhammad T., Beaven, Robin, Koyama, Takashi, Naz, Sehrish, Su, Sheng-yuan, Leader, David P. ORCID: https://orcid.org/0000-0002-0635-1843, A. Klaerke, Dan, Calloe, Kirstine, Denholm, Barry and Halberg, Kenneth V.
(2023)
NHA1 is a cation/proton antiporter essential for the water-conserving functions of the rectal complex in Tribolium castaneum.
Proceedings of the National Academy of Sciences of the United States of America, 120(13),
e221708412.
(doi: 10.1073/pnas.2217084120)
(PMID:36943876)
Leader, David P. ORCID: https://orcid.org/0000-0002-0635-1843 and Milner-White, E. James
(2023)
The conserved crown bridge loop at the catalytic centre of enzymes of the haloacid dehalogenase superfamily.
Current Research in Structural Biology, 6,
100105.
(doi: 10.1016/j.crstbi.2023.100105)
(PMID:37786806)
(PMCID:PMC10541634)
2022
Krause, Sue A. ORCID: https://orcid.org/0000-0003-1943-2703, Overend, Gayle
ORCID: https://orcid.org/0000-0003-4033-1747, Dow, Julian A.T.
ORCID: https://orcid.org/0000-0002-9595-5146 and Leader, David P.
ORCID: https://orcid.org/0000-0002-0635-1843
(2022)
FlyAtlas 2 in 2022: enhancements to the Drosophila melanogaster expression atlas.
Nucleic Acids Research, 50(D1),
D1010-D1015.
(doi: 10.1093/nar/gkab971)
(PMID:34718735)
(PMCID:PMC8728208)
2021
Leader, D.P. ORCID: https://orcid.org/0000-0002-0635-1843 and Milner-White, E.J.
(2021)
The β-link motif in protein architecture.
Acta Crystallographica Section D: Structural Biology, 77(8),
pp. 1040-1049.
(doi: 10.1107/S2059798321006768)
Leader, David P. ORCID: https://orcid.org/0000-0002-0635-1843 and Milner-White, James E.
(2021)
Identification and characterization of two classes of G1 β-bulge.
Acta Crystallographica. Section D: Structural Biology, 77(2),
(doi: 10.1107/S2059798320015533)
(PMID:33559610)
(PMCID:PMC7869896)
2017
Leader, David P. ORCID: https://orcid.org/0000-0002-0635-1843, Krause, Sue A.
ORCID: https://orcid.org/0000-0003-1943-2703, Pandit, Aniruddha
ORCID: https://orcid.org/0000-0002-6995-2865, Davies, Shireen A.
ORCID: https://orcid.org/0000-0002-0472-1302 and Dow, Julian A.T.
ORCID: https://orcid.org/0000-0002-9595-5146
(2017)
FlyAtlas 2: a new version of the Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data.
Nucleic Acids Research, 46(D1),
D809-D815.
(doi: 10.1093/nar/gkx976)
(PMID:29069479)
(PMCID:PMC5753349)
2015
Leader, David P. ORCID: https://orcid.org/0000-0002-0635-1843 and Milner-White, James
(2015)
Bridging of partially negative atoms by hydrogen bonds from main-chain NH groups in proteins: the crown motif.
Proteins: Structure Function and Bioinformatics, 83(11),
pp. 2067-2076.
(doi: 10.1002/prot.24923)
(PMID:26358948)
2014
Afzal, Avid M., Al-Shubailly, Fawzia, Leader, David P. ORCID: https://orcid.org/0000-0002-0635-1843 and Milner-White, E. James
(2014)
Bridging of anions by hydrogen bonds in nest motifs and its significance for Schellman loops and other larger motifs within proteins.
Proteins: Structure Function and Bioinformatics, 82(11),
pp. 3023-3031.
(doi: 10.1002/prot.24663)
Hayward, S., Leader, D.P. ORCID: https://orcid.org/0000-0002-0635-1843, Al-Shubailly, F. and Milner-White, E.J.
(2014)
Rings and ribbons in protein structures: characterization using helical parameters and Ramachandran plots for repeating dipeptides.
Proteins: Structure Function and Bioinformatics, 82(2),
pp. 230-239.
(doi: 10.1002/prot.24357)
2013
Robinson, S.W., Herzyk, P. ORCID: https://orcid.org/0000-0002-7439-292X, Dow, J.A.T.
ORCID: https://orcid.org/0000-0002-9595-5146 and Leader, D.P.
ORCID: https://orcid.org/0000-0002-0635-1843
(2013)
FlyAtlas: database of gene expression in the tissues of drosophila melanogaster.
Nucleic Acids Research, 41(D1),
D744-D750.
(doi: 10.1093/nar/gks1141)
(PMID:23203866)
(PMCID:PMC3531048)
2012
Leader, D.P. ORCID: https://orcid.org/0000-0002-0635-1843 and Milner-White, E.J.
(2012)
Structure motivator: a tool for exploring small three-dimensional elements in proteins.
BMC Structural Biology, 12(1),
p. 26.
(doi: 10.1186/1472-6807-12-26)
2011
Leader, D.P. ORCID: https://orcid.org/0000-0002-0635-1843, Burgess, K., Creek, D. and Barrett, M.P.
ORCID: https://orcid.org/0000-0001-9447-3519
(2011)
Pathos: a web facility that uses metabolic maps to display experimental changes in metabolites identified by mass spectrometry.
Rapid Communications in Mass Spectrometry, 25(22),
pp. 3422-3426.
(doi: 10.1002/rcm.5245)
Leader, D.P. ORCID: https://orcid.org/0000-0002-0635-1843 and Milner-White, E.J.
(2011)
The structure of the ends of α-helices in globular proteins: Effect of additional hydrogen bonds and implications for helix formation.
Proteins: Structure Function and Bioinformatics, 79(3),
pp. 1010-1019.
(doi: 10.1002/prot.22942)
2009
Leader, D.P. ORCID: https://orcid.org/0000-0002-0635-1843 and Milner-White, E.J.
(2009)
Motivated proteins: a web application for studying small three-dimensional protein motifs.
BMC Bioinformatics, 10(60),
(doi: 10.1186/1471-2105-10-60)
Torrance, G.M., Leader, D.P., Gilbert, D.R. and Milner-White, E.J. (2009) A novel main chain motif in proteins bridged by cationic groups: the niche. Journal of Molecular Biology, 385(4), pp. 1076-1086. (doi: 10.1016/j.jmb.2008.11.007)
2005
Jakubowska, Joanna, Hunt, Ela, Chalmers, Matthew ORCID: https://orcid.org/0000-0001-9816-668X, Leader, David
ORCID: https://orcid.org/0000-0002-0635-1843, McBride, Martin
ORCID: https://orcid.org/0000-0002-6323-124X and Dominiczak, Anna F.
ORCID: https://orcid.org/0000-0003-4913-3608
(2005)
System level visualization of eQTLs and pQTLs.
BMC Bioinformatics, 6(Sup 3),
P15.
(doi: 10.1186/1471-2105-6-S3-P15)
2004
Hunt, E., Hanlon, N., Leader, D.P., Bryce, H. and Dominiczak, A.F. (2004) The visual language of synteny. OMICS: A Journal of Integrative Biology, 8(4), pp. 289-305. (doi: 10.1089/omi.2004.8.289.)
Leader, D.P. ORCID: https://orcid.org/0000-0002-0635-1843
(2004)
BugView: a browser for comparing genomes.
Bioinformatics, 20,
pp. 129-130.
(doi: 10.1093/bioinformatics/btg383)
Leader, D.P. ORCID: https://orcid.org/0000-0002-0635-1843
(2004)
Genome browsing 'for the rest of us' - software and resources for visualizing genomic data.
Biochemist, 26(4),
pp. 7-11.
2000
Brown, N.G., Morrice, D.N., Beaud, G., Hardie, G. and Leader, D.P. ORCID: https://orcid.org/0000-0002-0635-1843
(2000)
Identification of sites phosphorylated by the vaccinia virus B1R kinase in viral protein H5R.
BMC Biochemistry, 1(2),
Articles
Leader, David P. ORCID: https://orcid.org/0000-0002-0635-1843, Naseem, Muhammad T. and Halberg, Kenneth V.
(2024)
BeetleAtlas: an ontogenetic and tissue-specific transcriptomic atlas of the red flour beetle Tribolium castaneum.
Journal of Molecular Biology, 436(17),
168520.
(doi: 10.1016/j.jmb.2024.168520)
Leader, David P. ORCID: https://orcid.org/0000-0002-0635-1843
(2024)
E. James Milner-White (1945–2023).
Proteins: Structure Function and Bioinformatics, 92(6),
pp. 691-692.
(doi: 10.1002/prot.26664)
(PMID:38197126)
Leader, David P. ORCID: https://orcid.org/0000-0002-0635-1843 and Coggins, John R.
(2024)
E. James Milner-White, 1945–2023.
Biochemist, 46(1),
pp. 34-35.
(doi: 10.1042/bio_2024_108)
Naseem, Muhammad T., Beaven, Robin, Koyama, Takashi, Naz, Sehrish, Su, Sheng-yuan, Leader, David P. ORCID: https://orcid.org/0000-0002-0635-1843, A. Klaerke, Dan, Calloe, Kirstine, Denholm, Barry and Halberg, Kenneth V.
(2023)
NHA1 is a cation/proton antiporter essential for the water-conserving functions of the rectal complex in Tribolium castaneum.
Proceedings of the National Academy of Sciences of the United States of America, 120(13),
e221708412.
(doi: 10.1073/pnas.2217084120)
(PMID:36943876)
Leader, David P. ORCID: https://orcid.org/0000-0002-0635-1843 and Milner-White, E. James
(2023)
The conserved crown bridge loop at the catalytic centre of enzymes of the haloacid dehalogenase superfamily.
Current Research in Structural Biology, 6,
100105.
(doi: 10.1016/j.crstbi.2023.100105)
(PMID:37786806)
(PMCID:PMC10541634)
Krause, Sue A. ORCID: https://orcid.org/0000-0003-1943-2703, Overend, Gayle
ORCID: https://orcid.org/0000-0003-4033-1747, Dow, Julian A.T.
ORCID: https://orcid.org/0000-0002-9595-5146 and Leader, David P.
ORCID: https://orcid.org/0000-0002-0635-1843
(2022)
FlyAtlas 2 in 2022: enhancements to the Drosophila melanogaster expression atlas.
Nucleic Acids Research, 50(D1),
D1010-D1015.
(doi: 10.1093/nar/gkab971)
(PMID:34718735)
(PMCID:PMC8728208)
Leader, D.P. ORCID: https://orcid.org/0000-0002-0635-1843 and Milner-White, E.J.
(2021)
The β-link motif in protein architecture.
Acta Crystallographica Section D: Structural Biology, 77(8),
pp. 1040-1049.
(doi: 10.1107/S2059798321006768)
Leader, David P. ORCID: https://orcid.org/0000-0002-0635-1843 and Milner-White, James E.
(2021)
Identification and characterization of two classes of G1 β-bulge.
Acta Crystallographica. Section D: Structural Biology, 77(2),
(doi: 10.1107/S2059798320015533)
(PMID:33559610)
(PMCID:PMC7869896)
Leader, David P. ORCID: https://orcid.org/0000-0002-0635-1843, Krause, Sue A.
ORCID: https://orcid.org/0000-0003-1943-2703, Pandit, Aniruddha
ORCID: https://orcid.org/0000-0002-6995-2865, Davies, Shireen A.
ORCID: https://orcid.org/0000-0002-0472-1302 and Dow, Julian A.T.
ORCID: https://orcid.org/0000-0002-9595-5146
(2017)
FlyAtlas 2: a new version of the Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data.
Nucleic Acids Research, 46(D1),
D809-D815.
(doi: 10.1093/nar/gkx976)
(PMID:29069479)
(PMCID:PMC5753349)
Leader, David P. ORCID: https://orcid.org/0000-0002-0635-1843 and Milner-White, James
(2015)
Bridging of partially negative atoms by hydrogen bonds from main-chain NH groups in proteins: the crown motif.
Proteins: Structure Function and Bioinformatics, 83(11),
pp. 2067-2076.
(doi: 10.1002/prot.24923)
(PMID:26358948)
Afzal, Avid M., Al-Shubailly, Fawzia, Leader, David P. ORCID: https://orcid.org/0000-0002-0635-1843 and Milner-White, E. James
(2014)
Bridging of anions by hydrogen bonds in nest motifs and its significance for Schellman loops and other larger motifs within proteins.
Proteins: Structure Function and Bioinformatics, 82(11),
pp. 3023-3031.
(doi: 10.1002/prot.24663)
Hayward, S., Leader, D.P. ORCID: https://orcid.org/0000-0002-0635-1843, Al-Shubailly, F. and Milner-White, E.J.
(2014)
Rings and ribbons in protein structures: characterization using helical parameters and Ramachandran plots for repeating dipeptides.
Proteins: Structure Function and Bioinformatics, 82(2),
pp. 230-239.
(doi: 10.1002/prot.24357)
Robinson, S.W., Herzyk, P. ORCID: https://orcid.org/0000-0002-7439-292X, Dow, J.A.T.
ORCID: https://orcid.org/0000-0002-9595-5146 and Leader, D.P.
ORCID: https://orcid.org/0000-0002-0635-1843
(2013)
FlyAtlas: database of gene expression in the tissues of drosophila melanogaster.
Nucleic Acids Research, 41(D1),
D744-D750.
(doi: 10.1093/nar/gks1141)
(PMID:23203866)
(PMCID:PMC3531048)
Leader, D.P. ORCID: https://orcid.org/0000-0002-0635-1843 and Milner-White, E.J.
(2012)
Structure motivator: a tool for exploring small three-dimensional elements in proteins.
BMC Structural Biology, 12(1),
p. 26.
(doi: 10.1186/1472-6807-12-26)
Leader, D.P. ORCID: https://orcid.org/0000-0002-0635-1843, Burgess, K., Creek, D. and Barrett, M.P.
ORCID: https://orcid.org/0000-0001-9447-3519
(2011)
Pathos: a web facility that uses metabolic maps to display experimental changes in metabolites identified by mass spectrometry.
Rapid Communications in Mass Spectrometry, 25(22),
pp. 3422-3426.
(doi: 10.1002/rcm.5245)
Leader, D.P. ORCID: https://orcid.org/0000-0002-0635-1843 and Milner-White, E.J.
(2011)
The structure of the ends of α-helices in globular proteins: Effect of additional hydrogen bonds and implications for helix formation.
Proteins: Structure Function and Bioinformatics, 79(3),
pp. 1010-1019.
(doi: 10.1002/prot.22942)
Leader, D.P. ORCID: https://orcid.org/0000-0002-0635-1843 and Milner-White, E.J.
(2009)
Motivated proteins: a web application for studying small three-dimensional protein motifs.
BMC Bioinformatics, 10(60),
(doi: 10.1186/1471-2105-10-60)
Torrance, G.M., Leader, D.P., Gilbert, D.R. and Milner-White, E.J. (2009) A novel main chain motif in proteins bridged by cationic groups: the niche. Journal of Molecular Biology, 385(4), pp. 1076-1086. (doi: 10.1016/j.jmb.2008.11.007)
Jakubowska, Joanna, Hunt, Ela, Chalmers, Matthew ORCID: https://orcid.org/0000-0001-9816-668X, Leader, David
ORCID: https://orcid.org/0000-0002-0635-1843, McBride, Martin
ORCID: https://orcid.org/0000-0002-6323-124X and Dominiczak, Anna F.
ORCID: https://orcid.org/0000-0003-4913-3608
(2005)
System level visualization of eQTLs and pQTLs.
BMC Bioinformatics, 6(Sup 3),
P15.
(doi: 10.1186/1471-2105-6-S3-P15)
Hunt, E., Hanlon, N., Leader, D.P., Bryce, H. and Dominiczak, A.F. (2004) The visual language of synteny. OMICS: A Journal of Integrative Biology, 8(4), pp. 289-305. (doi: 10.1089/omi.2004.8.289.)
Leader, D.P. ORCID: https://orcid.org/0000-0002-0635-1843
(2004)
BugView: a browser for comparing genomes.
Bioinformatics, 20,
pp. 129-130.
(doi: 10.1093/bioinformatics/btg383)
Leader, D.P. ORCID: https://orcid.org/0000-0002-0635-1843
(2004)
Genome browsing 'for the rest of us' - software and resources for visualizing genomic data.
Biochemist, 26(4),
pp. 7-11.
Brown, N.G., Morrice, D.N., Beaud, G., Hardie, G. and Leader, D.P. ORCID: https://orcid.org/0000-0002-0635-1843
(2000)
Identification of sites phosphorylated by the vaccinia virus B1R kinase in viral protein H5R.
BMC Biochemistry, 1(2),