Dr Gillian Borland
- Research Associate (Molecular Biosciences)
telephone:
01413306454
email:
Gillian.Borland@glasgow.ac.uk
pronouns:
She/her/hers
School of Molecular Biosciences, Davidson Building Lab 241, University Avenue, Glasgow, G12 8QQ
Publications
2024
Malik, Y. et al. (2024) Disruption of tRNA biogenesis enhances proteostatic resilience, improves later-life health, and promotes longevity. PLoS Biology, 22(10), e3002853. (doi: 10.1371/journal.pbio.3002853) (PMID:39436952) (PMCID:PMC11495624)
Borland, Gillian, Wilkie, Stephen E., Thomson, Jackie, Wang, Zhe, Tullett, Jennifer M.A., Alic, Nazif and Selman, Colin ORCID: https://orcid.org/0000-0002-8727-0593
(2024)
Polr3b heterozygosity in mice induces both beneficial and deleterious effects on health during ageing with no effect on lifespan.
Aging Cell, 23(5),
e14141.
(doi: 10.1111/acel.14141)
(PMID:38465473)
(PMCID:PMC11113255)
2021
Wilkie, Stephen E., Borland, Gillian, Carter, Roderick N., Morton, Nicholas M. and Selman, Colin ORCID: https://orcid.org/0000-0002-8727-0593
(2021)
Hydrogen sulfide in ageing, longevity and disease.
Biochemical Journal, 478(19),
pp. 3485-3504.
(doi: 10.1042/BCJ20210517)
(PMID:34613340)
(PMCID:PMC8589328)
Mulvey, Lorna, Wilkie, Stephen E., Borland, Gillian, Griffiths, Kate, Sinclair, Amy, McGuinness, Dagmara ORCID: https://orcid.org/0000-0001-9057-3504, Watson, David G. and Selman, Colin
ORCID: https://orcid.org/0000-0002-8727-0593
(2021)
Strain-specific metabolic responses to long-term caloric restriction in female ILSXISS recombinant inbred mice.
Molecular and Cellular Endocrinology, 535,
111376.
(doi: 10.1016/j.mce.2021.111376)
(PMID:34246728)
(PMCID:PMC8417819)
Kulaberoglu, Yavuz, Malik, Yasir, Borland, Gillian, Selman, Colin ORCID: https://orcid.org/0000-0002-8727-0593, Alic, Nazif and Tullet, Jennifer M.A.
(2021)
RNA polymerase III, ageing and longevity.
Frontiers in Genetics, 12,
705122.
(doi: 10.3389/fgene.2021.705122)
(PMID:34295356)
(PMCID:PMC8290157)
2019
Loyola, L. et al. (2019) Disrupting MLV integrase:BET protein interaction biases integration into quiescent chromatin and delays but does not eliminate tumor activation in a MYC/Runx2 mouse model. PLoS Pathogens, 15(12), e1008154. (doi: 10.1371/journal.ppat.1008154) (PMID:31815961) (PMCID:PMC6974304)
2018
Anderson, G. et al. (2018) RUNX-mediated growth arrest and senescence are attenuated by diverse mechanisms in cells expressing RUNX1 fusion oncoproteins. Journal of Cellular Biochemistry, 119(3), pp. 2750-2762. (doi: 10.1002/jcb.26443) (PMID:29052866) (PMCID:PMC5813226)
2017
Neil, James C. ORCID: https://orcid.org/0000-0003-4447-8279, Hay, Jodie
ORCID: https://orcid.org/0000-0002-2000-2578 and Borland, Gillian
(2017)
RUNX oncoproteins and miRNA networks.
Oncotarget, 8(38),
pp. 62818-62819.
(doi: 10.18632/oncotarget.20673)
(PMID:28968950)
(PMCID:PMC5609882)
Kilbey, A. et al. (2017) Runx1 orchestrates sphingolipid metabolism and glucocorticoid resistance in lymphomagenesis. Journal of Cellular Biochemistry, 118(6), pp. 1432-1441. (doi: 10.1002/jcb.25802) (PMID:27869314) (PMCID:PMC5408393)
Neil, James C. ORCID: https://orcid.org/0000-0003-4447-8279, Gilroy, Kathryn, Borland, Gillian, Hay, Jodie
ORCID: https://orcid.org/0000-0002-2000-2578, Terry, Anne and Kilbey, Anna
(2017)
The RUNX genes as conditional oncogenes: insights from retroviral targeting and mouse models.
In: Groner, Yoram, Ito, Yoshiaki, Liu, Paul, Neil, James C., Speck, Nancy A. and van Wijnen, Andre (eds.)
RUNX Proteins in Development and Cancer.
Series: Advances in experimental medicine and biology (962).
Springer, pp. 247-264.
ISBN 9789811032318
(doi: 10.1007/978-981-10-3233-2_16)
2016
Neil, James C. ORCID: https://orcid.org/0000-0003-4447-8279, Borland, Gillian and Kilbey, Anna
(2016)
Addiction to RUNX in lymphoma.
Aging, 8(9),
pp. 1832-1833.
(doi: 10.18632/aging.101071)
(PMID:27688195)
(PMCID:PMC5076437)
Borland, G. et al. (2016) Addiction to Runx1 is partially attenuated by loss of p53 in the Eμ-Myc lymphoma model. Oncotarget, 7(17), pp. 22973-22987. (doi: 10.18632/oncotarget.8554) (PMID:27056890) (PMCID:PMC5029604)
2014
Huser, C. A. et al. (2014) Insertional mutagenesis and deep profiling reveals gene hierarchies and a Myc/p53-dependent bottleneck in lymphomagenesis. PLoS Genetics, 10(2), e1004167. (doi: 10.1371/journal.pgen.1004167) (PMID:24586197) (PMCID:PMC3937229)
2012
Edkins, A.L., Borland, G., Kelly, S.M. ORCID: https://orcid.org/0000-0002-3516-1387, Cogdell, R.J.
ORCID: https://orcid.org/0000-0003-2119-6607, Ozanne, B.W. and Cushley, W.
(2012)
Analysis of the CD23-αv integrin interaction: a study with model peptides.
Biochemical and Biophysical Research Communications, 422(2),
pp. 207-212.
(doi: 10.1016/j.bbrc.2012.04.076)
Wiejak, Jolanta, Dunlop, Julia ORCID: https://orcid.org/0000-0003-3180-6763, Gao, Shan, Borland, Gillian and Yarwood, Stephen J.
(2012)
Extracellular signal-regulated kinase mitogen-activated protein kinase-dependent SOCS-3 gene induction requires c-Jun, signal transducer and activator of transcription 3, and specificity protein 3 transcription factors.
Molecular Pharmacology, 81(5),
pp. 657-668.
(doi: 10.1124/mol.111.076976)
Edkins, A.L., Borland, G., Acharya, M., Cogdell, R.J. ORCID: https://orcid.org/0000-0003-2119-6607, Ozanne, B.W. and Cushley, W.
(2012)
Differential regulation of monocyte cytokine release by αv and β2 integrins that bind CD23.
Immunology, 136(2),
pp. 241-251.
(doi: 10.1111/j.1365-2567.2012.03576.x)
2010
Kilbey, A., Terry, A., Jenkins, A., Borland, G., Zhang, Q.F., Wakelam, M.J.O., Cameron, E.R. ORCID: https://orcid.org/0000-0001-8311-1491 and Neil, J.C.
ORCID: https://orcid.org/0000-0003-4447-8279
(2010)
Runx regulation of sphingolipid metabolism and survival signaling.
Cancer Research, 70(14),
pp. 5860-5869.
(doi: 10.1158/0008-5472.CAN-10-0726)
2009
Borland, Gillian, Bird, Rebecca J., Palmer, Timothy M. and Yarwood, Stephen J. (2009) Activation of protein kinase Cα by EPAC1 is required for the ERK- and CCAAT/enhancer-binding protein β-dependent induction of the SOCS-3 gene by cyclic AMP in COS1 cells. Journal of Biological Chemistry, 284(26), pp. 17391-17403. (doi: 10.1074/jbc.M109.015370) (PMID:19423709) (PMCID:PMC2719379)
Borland, G., Smith, B.O. and Yarwood, S.J. (2009) EPAC proteins transduce diverse cellular actions of cAMP. British Journal of Pharmacology, 158(1), pp. 70-86. (doi: 10.1111/j.1476-5381.2008.00087.x)
2008
Yarwood, S.J., Borland, G., Sands, W.A. and Palmer, T.M. (2008) Identification of CCAAT/Enhancer-binding proteins as exchange protein activated by cAMP-activated transcription factors that mediate the induction of the SOCS-3 gene. Journal of Biological Chemistry, 283(11), pp. 6843-6853. (doi: 10.1074/jbc.M710342200)
2007
Borland, G., Edkins, A.L., Acharya, M., Matheson, J., White, L.J., Allen, J.M., Bonnefoy, J.-Y., Ozanne, B. W. and Cushley, W. (2007) vbeta5 Integrin Sustains Growth of Human Pre-B Cells through an RGD-independent Interaction with a Basic Domain of the CD23 Protein. Journal of Biological Chemistry, 282(37), pp. 27315-27326. (doi: 10.1074/jbc.M609335200)
Articles
Malik, Y. et al. (2024) Disruption of tRNA biogenesis enhances proteostatic resilience, improves later-life health, and promotes longevity. PLoS Biology, 22(10), e3002853. (doi: 10.1371/journal.pbio.3002853) (PMID:39436952) (PMCID:PMC11495624)
Borland, Gillian, Wilkie, Stephen E., Thomson, Jackie, Wang, Zhe, Tullett, Jennifer M.A., Alic, Nazif and Selman, Colin ORCID: https://orcid.org/0000-0002-8727-0593
(2024)
Polr3b heterozygosity in mice induces both beneficial and deleterious effects on health during ageing with no effect on lifespan.
Aging Cell, 23(5),
e14141.
(doi: 10.1111/acel.14141)
(PMID:38465473)
(PMCID:PMC11113255)
Wilkie, Stephen E., Borland, Gillian, Carter, Roderick N., Morton, Nicholas M. and Selman, Colin ORCID: https://orcid.org/0000-0002-8727-0593
(2021)
Hydrogen sulfide in ageing, longevity and disease.
Biochemical Journal, 478(19),
pp. 3485-3504.
(doi: 10.1042/BCJ20210517)
(PMID:34613340)
(PMCID:PMC8589328)
Mulvey, Lorna, Wilkie, Stephen E., Borland, Gillian, Griffiths, Kate, Sinclair, Amy, McGuinness, Dagmara ORCID: https://orcid.org/0000-0001-9057-3504, Watson, David G. and Selman, Colin
ORCID: https://orcid.org/0000-0002-8727-0593
(2021)
Strain-specific metabolic responses to long-term caloric restriction in female ILSXISS recombinant inbred mice.
Molecular and Cellular Endocrinology, 535,
111376.
(doi: 10.1016/j.mce.2021.111376)
(PMID:34246728)
(PMCID:PMC8417819)
Kulaberoglu, Yavuz, Malik, Yasir, Borland, Gillian, Selman, Colin ORCID: https://orcid.org/0000-0002-8727-0593, Alic, Nazif and Tullet, Jennifer M.A.
(2021)
RNA polymerase III, ageing and longevity.
Frontiers in Genetics, 12,
705122.
(doi: 10.3389/fgene.2021.705122)
(PMID:34295356)
(PMCID:PMC8290157)
Loyola, L. et al. (2019) Disrupting MLV integrase:BET protein interaction biases integration into quiescent chromatin and delays but does not eliminate tumor activation in a MYC/Runx2 mouse model. PLoS Pathogens, 15(12), e1008154. (doi: 10.1371/journal.ppat.1008154) (PMID:31815961) (PMCID:PMC6974304)
Anderson, G. et al. (2018) RUNX-mediated growth arrest and senescence are attenuated by diverse mechanisms in cells expressing RUNX1 fusion oncoproteins. Journal of Cellular Biochemistry, 119(3), pp. 2750-2762. (doi: 10.1002/jcb.26443) (PMID:29052866) (PMCID:PMC5813226)
Neil, James C. ORCID: https://orcid.org/0000-0003-4447-8279, Hay, Jodie
ORCID: https://orcid.org/0000-0002-2000-2578 and Borland, Gillian
(2017)
RUNX oncoproteins and miRNA networks.
Oncotarget, 8(38),
pp. 62818-62819.
(doi: 10.18632/oncotarget.20673)
(PMID:28968950)
(PMCID:PMC5609882)
Kilbey, A. et al. (2017) Runx1 orchestrates sphingolipid metabolism and glucocorticoid resistance in lymphomagenesis. Journal of Cellular Biochemistry, 118(6), pp. 1432-1441. (doi: 10.1002/jcb.25802) (PMID:27869314) (PMCID:PMC5408393)
Neil, James C. ORCID: https://orcid.org/0000-0003-4447-8279, Borland, Gillian and Kilbey, Anna
(2016)
Addiction to RUNX in lymphoma.
Aging, 8(9),
pp. 1832-1833.
(doi: 10.18632/aging.101071)
(PMID:27688195)
(PMCID:PMC5076437)
Borland, G. et al. (2016) Addiction to Runx1 is partially attenuated by loss of p53 in the Eμ-Myc lymphoma model. Oncotarget, 7(17), pp. 22973-22987. (doi: 10.18632/oncotarget.8554) (PMID:27056890) (PMCID:PMC5029604)
Huser, C. A. et al. (2014) Insertional mutagenesis and deep profiling reveals gene hierarchies and a Myc/p53-dependent bottleneck in lymphomagenesis. PLoS Genetics, 10(2), e1004167. (doi: 10.1371/journal.pgen.1004167) (PMID:24586197) (PMCID:PMC3937229)
Edkins, A.L., Borland, G., Kelly, S.M. ORCID: https://orcid.org/0000-0002-3516-1387, Cogdell, R.J.
ORCID: https://orcid.org/0000-0003-2119-6607, Ozanne, B.W. and Cushley, W.
(2012)
Analysis of the CD23-αv integrin interaction: a study with model peptides.
Biochemical and Biophysical Research Communications, 422(2),
pp. 207-212.
(doi: 10.1016/j.bbrc.2012.04.076)
Wiejak, Jolanta, Dunlop, Julia ORCID: https://orcid.org/0000-0003-3180-6763, Gao, Shan, Borland, Gillian and Yarwood, Stephen J.
(2012)
Extracellular signal-regulated kinase mitogen-activated protein kinase-dependent SOCS-3 gene induction requires c-Jun, signal transducer and activator of transcription 3, and specificity protein 3 transcription factors.
Molecular Pharmacology, 81(5),
pp. 657-668.
(doi: 10.1124/mol.111.076976)
Edkins, A.L., Borland, G., Acharya, M., Cogdell, R.J. ORCID: https://orcid.org/0000-0003-2119-6607, Ozanne, B.W. and Cushley, W.
(2012)
Differential regulation of monocyte cytokine release by αv and β2 integrins that bind CD23.
Immunology, 136(2),
pp. 241-251.
(doi: 10.1111/j.1365-2567.2012.03576.x)
Kilbey, A., Terry, A., Jenkins, A., Borland, G., Zhang, Q.F., Wakelam, M.J.O., Cameron, E.R. ORCID: https://orcid.org/0000-0001-8311-1491 and Neil, J.C.
ORCID: https://orcid.org/0000-0003-4447-8279
(2010)
Runx regulation of sphingolipid metabolism and survival signaling.
Cancer Research, 70(14),
pp. 5860-5869.
(doi: 10.1158/0008-5472.CAN-10-0726)
Borland, Gillian, Bird, Rebecca J., Palmer, Timothy M. and Yarwood, Stephen J. (2009) Activation of protein kinase Cα by EPAC1 is required for the ERK- and CCAAT/enhancer-binding protein β-dependent induction of the SOCS-3 gene by cyclic AMP in COS1 cells. Journal of Biological Chemistry, 284(26), pp. 17391-17403. (doi: 10.1074/jbc.M109.015370) (PMID:19423709) (PMCID:PMC2719379)
Borland, G., Smith, B.O. and Yarwood, S.J. (2009) EPAC proteins transduce diverse cellular actions of cAMP. British Journal of Pharmacology, 158(1), pp. 70-86. (doi: 10.1111/j.1476-5381.2008.00087.x)
Yarwood, S.J., Borland, G., Sands, W.A. and Palmer, T.M. (2008) Identification of CCAAT/Enhancer-binding proteins as exchange protein activated by cAMP-activated transcription factors that mediate the induction of the SOCS-3 gene. Journal of Biological Chemistry, 283(11), pp. 6843-6853. (doi: 10.1074/jbc.M710342200)
Borland, G., Edkins, A.L., Acharya, M., Matheson, J., White, L.J., Allen, J.M., Bonnefoy, J.-Y., Ozanne, B. W. and Cushley, W. (2007) vbeta5 Integrin Sustains Growth of Human Pre-B Cells through an RGD-independent Interaction with a Basic Domain of the CD23 Protein. Journal of Biological Chemistry, 282(37), pp. 27315-27326. (doi: 10.1074/jbc.M609335200)
Book Sections
Neil, James C. ORCID: https://orcid.org/0000-0003-4447-8279, Gilroy, Kathryn, Borland, Gillian, Hay, Jodie
ORCID: https://orcid.org/0000-0002-2000-2578, Terry, Anne and Kilbey, Anna
(2017)
The RUNX genes as conditional oncogenes: insights from retroviral targeting and mouse models.
In: Groner, Yoram, Ito, Yoshiaki, Liu, Paul, Neil, James C., Speck, Nancy A. and van Wijnen, Andre (eds.)
RUNX Proteins in Development and Cancer.
Series: Advances in experimental medicine and biology (962).
Springer, pp. 247-264.
ISBN 9789811032318
(doi: 10.1007/978-981-10-3233-2_16)