2025

Sharma, V. et al. (2025) A 1-year weight management program for difficult-to-treat asthma with obesity: a randomized controlled study. Chest, 167(1), pp. 42-53. (doi: 10.1016/j.chest.2024.09.042) (PMID:39427706) (PMCID:PMC11752128)

2024

Combet, E. et al. (2024) Remotely delivered weight management for people with long COVID and overweight: the randomized wait-list-controlled ReDIRECT trial. Nature Medicine, 31(1), pp. 258-266. (doi: 10.1038/s41591-024-03384-x) (PMID:39779922) (PMCID:PMC11750722)

Lean, M. E.J. et al. (2024) 5-year follow-up of the randomised Diabetes Remission Clinical Trial (DiRECT) of continued support for weight loss maintenance in the UK: an extension study. Lancet Diabetes and Endocrinology, 12(4), pp. 233-246. (doi: 10.1016/S2213-8587(23)00385-6) (PMID:38423026)

Haag, L. et al. (2024) Baseline characteristics in the Remote Diet Intervention to REduce long-COVID Symptoms Trial (ReDIRECT). NIHR Open Research, 4, 7. (doi: 10.3310/nihropenres.13522.1) (PMID:39145102) (PMCID:PMC11320183)

2023

Haag, L. et al. (2023) The remote diet intervention to reduce Long COVID symptoms trial (ReDIRECT): protocol for a randomised controlled trial to determine the effectiveness and cost-effectiveness of a remotely delivered supported weight management programme for people with Long COVID and excess weight, with personalised improvement goals. NIHR Open Research, 2, 57. (doi: 10.3310/nihropenres.13315.2) (PMID:37881302) (PMCID:PMC10593354)

Sharma, Varun, Ricketts, Helen Clare, McCombie, Louise, Brosnahan, Naomi ORCID: https://orcid.org/0000-0002-3354-1060, Crawford, Luisa, Slaughter, Lesley, Goodfellow, Anna, Lean, Michael E.J. ORCID: https://orcid.org/0000-0003-2216-0083 and Cowan, Douglas C. ORCID: https://orcid.org/0000-0001-7297-9041 (2023) A total diet replacement weight management programme for difficult-to-treat asthma associated with obesity: a randomised controlled feasibility trial. Chest, 163(5), pp. 1026-1037. (doi: 10.1016/j.chest.2023.01.015) (PMID:36649753)

Cassidy, S. et al. (2023) Physical activity, inactivity and sleep during the Diabetes Remission Clinical Trial (DiRECT). Diabetic Medicine, 40(3), e15010. (doi: 10.1111/dme.15010) (PMID:36398460)

Sattar, Naveed ORCID: https://orcid.org/0000-0002-1604-2593, Welsh, Paul ORCID: https://orcid.org/0000-0002-7970-3643, Leslie, Wilma S., Thom, George ORCID: https://orcid.org/0000-0002-8871-9524, McCombie, Louise, Brosnahan, Naomi ORCID: https://orcid.org/0000-0002-3354-1060, Richardson, Janice ORCID: https://orcid.org/0000-0002-8207-0891, Gill, Jason M. R. ORCID: https://orcid.org/0000-0003-3615-0986, Crawford, Luisa and Lean, Michael E. J. ORCID: https://orcid.org/0000-0003-2216-0083 (2023) Dietary weight-management for type 2 diabetes remissions in South Asians: the South Asian diabetes remission randomised trial for proof-of-concept and feasibility (STANDby). Lancet Regional Health – Southeast Asia, 9, 100111. (doi: 10.1016/j.lansea.2022.100111) (PMID:36777452) (PMCID:PMC9904218)

2022

Brown, Adrian, Brosnahan, Naomi ORCID: https://orcid.org/0000-0002-3354-1060, Khazaei, Dorsa, Wingrove, Jed, Flint, Stuart W. and Batterham, Rachel L. (2022) UK dietitians' attitudes and experiences of formula very low- and low-energy diets in clinical practice. Clinical Obesity, 12(3), e12509. (doi: 10.1111/cob.12509) (PMID:35068081)

Rehackova, Lucia, Taylor, Roy, Lean, Mike ORCID: https://orcid.org/0000-0003-2216-0083, Barnes, Alison, McCombie, Louise, Thom, George ORCID: https://orcid.org/0000-0002-8871-9524, Brosnahan, Naomi ORCID: https://orcid.org/0000-0002-3354-1060, Leslie, Wilma S. and Sniehotta, Falko F. (2022) Delivering the Diabetes Remission Clinical Trial (DiRECT) in primary care: experiences of healthcare professionals. Diabetic Medicine, 39(3), e14752. (doi: 10.1111/dme.14752) (PMID:34837259)

Rehackova, L. et al. (2022) Participant experiences in the Diabetes REmission Clinical Trial (DiRECT). Diabetic Medicine, 39(1), e14689. (doi: 10.1111/dme.14689) (PMID:34519099)

2021

Leslie, W. S. et al. (2021) Antihypertensive medication needs and blood pressure control with weight loss in the Diabetes Remission Clinical Trial (DiRECT). Diabetologia, 64(9), pp. 1927-1938. (doi: 10.1007/s00125-021-05471-x) (PMID:34056684)

Thom, G. et al. (2021) Predictors of type 2 diabetes in the Diabetes Remission Clinical Trial (DiRECT). Diabetic Medicine, 38(8), e14395. (doi: 10.1111/dme.14395) (PMID:32870520)

Brosnahan, Naomi ORCID: https://orcid.org/0000-0002-3354-1060, Leslie, Wilma, McCombie, Louise, Barnes, Alison, Thom, George ORCID: https://orcid.org/0000-0002-8871-9524, McConnachie, Alex ORCID: https://orcid.org/0000-0002-7262-7000, Messow, Claudia Martina ORCID: https://orcid.org/0000-0003-0082-9946, Sattar, Naveed ORCID: https://orcid.org/0000-0002-1604-2593, Taylor, Roy and Lean, Michael E.J. ORCID: https://orcid.org/0000-0003-2216-0083 (2021) Brief formula low‐energy‐diet for relapse management during weight loss maintenance in the Diabetes Remission Clinical Trial (DiRECT). Journal of Human Nutrition and Dietetics, 34(3), pp. 472-479. (doi: 10.1111/jhn.12839) (PMID:33406285)

Thom, G. et al. (2021) Weight loss induced increase in fasting ghrelin concentration is a predictor of weight regain: evidence from the Diabetes Remission Clinical Trial. Diabetes, Obesity and Metabolism, 23(3), pp. 711-719. (doi: 10.1111/dom.14274) (PMID:33369058)

Thom, George ORCID: https://orcid.org/0000-0002-8871-9524, Lean, Michael E.J. ORCID: https://orcid.org/0000-0003-2216-0083, Brosnahan, Naomi ORCID: https://orcid.org/0000-0002-3354-1060, Algindan, Yasmin Y., Malkova, Dalia ORCID: https://orcid.org/0000-0002-8085-0528 and Dombrowski, Stephan U. (2021) ‘I have been all in, I have been all out and I have been everything in-between’: a 2-year longitudinal qualitative study of weight-loss maintenance. Journal of Human Nutrition and Dietetics, 34(1), pp. 199-214. (doi: 10.1111/jhn.12826) (PMID:33089558)

2020

Thom, George ORCID: https://orcid.org/0000-0002-8871-9524, Dombrowski, Stephan U., Brosnahan, Naomi ORCID: https://orcid.org/0000-0002-3354-1060, Algindan, Yasmin Y., Lopez-Gonzalez, M. Rosario, Roditi, Giles, Lean, Michael E.J. ORCID: https://orcid.org/0000-0003-2216-0083 and Malkova, Dalia ORCID: https://orcid.org/0000-0002-8085-0528 (2020) Response to comments on "The role of appetite-related hormones, adaptive thermogenesis, perceived hunger and stress in long-term weight-loss maintenance: a mixed methods study". European Journal of Clinical Nutrition, 74(7), pp. 1115-1116. (doi: 10.1038/s41430-020-0651-2) (PMID:32393752)

Thom, George ORCID: https://orcid.org/0000-0002-8871-9524, Dombrowski, Stephan U., Brosnahan, Naomi ORCID: https://orcid.org/0000-0002-3354-1060, Algindan, Yasmin Y., Rosario Lopez-Gonzalez, M., Roditi, Giles, Lean, Michael E.J. ORCID: https://orcid.org/0000-0003-2216-0083 and Malkova, Dalia ORCID: https://orcid.org/0000-0002-8085-0528 (2020) The role of appetite-related hormones, adaptive thermogenesis, perceived hunger and stress in long-term weight-loss maintenance: a mixed-methods study. European Journal of Clinical Nutrition, 74(4), pp. 622-632. (doi: 10.1038/s41430-020-0568-9) (PMID:32020057)

2019

McCombie, L., Brosnahan, N. ORCID: https://orcid.org/0000-0002-3354-1060, Ross, H., Bell-Higgs, A., Govan, L. and Lean, M.E.J. ORCID: https://orcid.org/0000-0003-2216-0083 (2019) Filling the intervention gap: service evaluation of an intensive nonsurgical weight management programme for severe and complex obesity. Journal of Human Nutrition and Dietetics, 32(3), pp. 329-337. (doi: 10.1111/jhn.12611) (PMID:30565772)

Lean, M. E.J. et al. (2019) Durability of a primary care-led weight-management intervention for remission of type 2 diabetes: 2-year results of the DiRECT open-label, cluster-randomised trial. Lancet Diabetes and Endocrinology, 7(5), pp. 344-355. (doi: 10.1016/S2213-8587(19)30068-3) (PMID:30852132)

2018

Taylor, R. et al. (2018) Clinical and metabolic features of the randomised controlled Diabetes Remission Clinical Trial (DiRECT) cohort. Diabetologia, 61(3), pp. 589-598. (doi: 10.1007/s00125-017-4503-0) (PMID:29188339)

Lean, M. E.J. et al. (2018) Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial. Lancet, 391(10120), pp. 541-551. (doi: 10.1016/S0140-6736(17)33102-1) (PMID:29221645)

2016

Leslie, W. S. et al. (2016) The Diabetes Remission Clinical Trial (DiRECT): protocol for a cluster randomised trial. BMC Family Practice, 17(1), (doi: 10.1186/s12875-016-0406-2) (PMID:26879684) (PMCID:PMC4754868)

Articles

Sharma, V. et al. (2025) A 1-year weight management program for difficult-to-treat asthma with obesity: a randomized controlled study. Chest, 167(1), pp. 42-53. (doi: 10.1016/j.chest.2024.09.042) (PMID:39427706) (PMCID:PMC11752128)

Combet, E. et al. (2024) Remotely delivered weight management for people with long COVID and overweight: the randomized wait-list-controlled ReDIRECT trial. Nature Medicine, 31(1), pp. 258-266. (doi: 10.1038/s41591-024-03384-x) (PMID:39779922) (PMCID:PMC11750722)

Lean, M. E.J. et al. (2024) 5-year follow-up of the randomised Diabetes Remission Clinical Trial (DiRECT) of continued support for weight loss maintenance in the UK: an extension study. Lancet Diabetes and Endocrinology, 12(4), pp. 233-246. (doi: 10.1016/S2213-8587(23)00385-6) (PMID:38423026)

Haag, L. et al. (2024) Baseline characteristics in the Remote Diet Intervention to REduce long-COVID Symptoms Trial (ReDIRECT). NIHR Open Research, 4, 7. (doi: 10.3310/nihropenres.13522.1) (PMID:39145102) (PMCID:PMC11320183)

Haag, L. et al. (2023) The remote diet intervention to reduce Long COVID symptoms trial (ReDIRECT): protocol for a randomised controlled trial to determine the effectiveness and cost-effectiveness of a remotely delivered supported weight management programme for people with Long COVID and excess weight, with personalised improvement goals. NIHR Open Research, 2, 57. (doi: 10.3310/nihropenres.13315.2) (PMID:37881302) (PMCID:PMC10593354)

Sharma, Varun, Ricketts, Helen Clare, McCombie, Louise, Brosnahan, Naomi ORCID: https://orcid.org/0000-0002-3354-1060, Crawford, Luisa, Slaughter, Lesley, Goodfellow, Anna, Lean, Michael E.J. ORCID: https://orcid.org/0000-0003-2216-0083 and Cowan, Douglas C. ORCID: https://orcid.org/0000-0001-7297-9041 (2023) A total diet replacement weight management programme for difficult-to-treat asthma associated with obesity: a randomised controlled feasibility trial. Chest, 163(5), pp. 1026-1037. (doi: 10.1016/j.chest.2023.01.015) (PMID:36649753)

Cassidy, S. et al. (2023) Physical activity, inactivity and sleep during the Diabetes Remission Clinical Trial (DiRECT). Diabetic Medicine, 40(3), e15010. (doi: 10.1111/dme.15010) (PMID:36398460)

Sattar, Naveed ORCID: https://orcid.org/0000-0002-1604-2593, Welsh, Paul ORCID: https://orcid.org/0000-0002-7970-3643, Leslie, Wilma S., Thom, George ORCID: https://orcid.org/0000-0002-8871-9524, McCombie, Louise, Brosnahan, Naomi ORCID: https://orcid.org/0000-0002-3354-1060, Richardson, Janice ORCID: https://orcid.org/0000-0002-8207-0891, Gill, Jason M. R. ORCID: https://orcid.org/0000-0003-3615-0986, Crawford, Luisa and Lean, Michael E. J. ORCID: https://orcid.org/0000-0003-2216-0083 (2023) Dietary weight-management for type 2 diabetes remissions in South Asians: the South Asian diabetes remission randomised trial for proof-of-concept and feasibility (STANDby). Lancet Regional Health – Southeast Asia, 9, 100111. (doi: 10.1016/j.lansea.2022.100111) (PMID:36777452) (PMCID:PMC9904218)

Brown, Adrian, Brosnahan, Naomi ORCID: https://orcid.org/0000-0002-3354-1060, Khazaei, Dorsa, Wingrove, Jed, Flint, Stuart W. and Batterham, Rachel L. (2022) UK dietitians' attitudes and experiences of formula very low- and low-energy diets in clinical practice. Clinical Obesity, 12(3), e12509. (doi: 10.1111/cob.12509) (PMID:35068081)

Rehackova, Lucia, Taylor, Roy, Lean, Mike ORCID: https://orcid.org/0000-0003-2216-0083, Barnes, Alison, McCombie, Louise, Thom, George ORCID: https://orcid.org/0000-0002-8871-9524, Brosnahan, Naomi ORCID: https://orcid.org/0000-0002-3354-1060, Leslie, Wilma S. and Sniehotta, Falko F. (2022) Delivering the Diabetes Remission Clinical Trial (DiRECT) in primary care: experiences of healthcare professionals. Diabetic Medicine, 39(3), e14752. (doi: 10.1111/dme.14752) (PMID:34837259)

Rehackova, L. et al. (2022) Participant experiences in the Diabetes REmission Clinical Trial (DiRECT). Diabetic Medicine, 39(1), e14689. (doi: 10.1111/dme.14689) (PMID:34519099)

Leslie, W. S. et al. (2021) Antihypertensive medication needs and blood pressure control with weight loss in the Diabetes Remission Clinical Trial (DiRECT). Diabetologia, 64(9), pp. 1927-1938. (doi: 10.1007/s00125-021-05471-x) (PMID:34056684)

Thom, G. et al. (2021) Predictors of type 2 diabetes in the Diabetes Remission Clinical Trial (DiRECT). Diabetic Medicine, 38(8), e14395. (doi: 10.1111/dme.14395) (PMID:32870520)

Brosnahan, Naomi ORCID: https://orcid.org/0000-0002-3354-1060, Leslie, Wilma, McCombie, Louise, Barnes, Alison, Thom, George ORCID: https://orcid.org/0000-0002-8871-9524, McConnachie, Alex ORCID: https://orcid.org/0000-0002-7262-7000, Messow, Claudia Martina ORCID: https://orcid.org/0000-0003-0082-9946, Sattar, Naveed ORCID: https://orcid.org/0000-0002-1604-2593, Taylor, Roy and Lean, Michael E.J. ORCID: https://orcid.org/0000-0003-2216-0083 (2021) Brief formula low‐energy‐diet for relapse management during weight loss maintenance in the Diabetes Remission Clinical Trial (DiRECT). Journal of Human Nutrition and Dietetics, 34(3), pp. 472-479. (doi: 10.1111/jhn.12839) (PMID:33406285)

Thom, G. et al. (2021) Weight loss induced increase in fasting ghrelin concentration is a predictor of weight regain: evidence from the Diabetes Remission Clinical Trial. Diabetes, Obesity and Metabolism, 23(3), pp. 711-719. (doi: 10.1111/dom.14274) (PMID:33369058)

Thom, George ORCID: https://orcid.org/0000-0002-8871-9524, Lean, Michael E.J. ORCID: https://orcid.org/0000-0003-2216-0083, Brosnahan, Naomi ORCID: https://orcid.org/0000-0002-3354-1060, Algindan, Yasmin Y., Malkova, Dalia ORCID: https://orcid.org/0000-0002-8085-0528 and Dombrowski, Stephan U. (2021) ‘I have been all in, I have been all out and I have been everything in-between’: a 2-year longitudinal qualitative study of weight-loss maintenance. Journal of Human Nutrition and Dietetics, 34(1), pp. 199-214. (doi: 10.1111/jhn.12826) (PMID:33089558)

Thom, George ORCID: https://orcid.org/0000-0002-8871-9524, Dombrowski, Stephan U., Brosnahan, Naomi ORCID: https://orcid.org/0000-0002-3354-1060, Algindan, Yasmin Y., Lopez-Gonzalez, M. Rosario, Roditi, Giles, Lean, Michael E.J. ORCID: https://orcid.org/0000-0003-2216-0083 and Malkova, Dalia ORCID: https://orcid.org/0000-0002-8085-0528 (2020) Response to comments on "The role of appetite-related hormones, adaptive thermogenesis, perceived hunger and stress in long-term weight-loss maintenance: a mixed methods study". European Journal of Clinical Nutrition, 74(7), pp. 1115-1116. (doi: 10.1038/s41430-020-0651-2) (PMID:32393752)

Thom, George ORCID: https://orcid.org/0000-0002-8871-9524, Dombrowski, Stephan U., Brosnahan, Naomi ORCID: https://orcid.org/0000-0002-3354-1060, Algindan, Yasmin Y., Rosario Lopez-Gonzalez, M., Roditi, Giles, Lean, Michael E.J. ORCID: https://orcid.org/0000-0003-2216-0083 and Malkova, Dalia ORCID: https://orcid.org/0000-0002-8085-0528 (2020) The role of appetite-related hormones, adaptive thermogenesis, perceived hunger and stress in long-term weight-loss maintenance: a mixed-methods study. European Journal of Clinical Nutrition, 74(4), pp. 622-632. (doi: 10.1038/s41430-020-0568-9) (PMID:32020057)

McCombie, L., Brosnahan, N. ORCID: https://orcid.org/0000-0002-3354-1060, Ross, H., Bell-Higgs, A., Govan, L. and Lean, M.E.J. ORCID: https://orcid.org/0000-0003-2216-0083 (2019) Filling the intervention gap: service evaluation of an intensive nonsurgical weight management programme for severe and complex obesity. Journal of Human Nutrition and Dietetics, 32(3), pp. 329-337. (doi: 10.1111/jhn.12611) (PMID:30565772)

Lean, M. E.J. et al. (2019) Durability of a primary care-led weight-management intervention for remission of type 2 diabetes: 2-year results of the DiRECT open-label, cluster-randomised trial. Lancet Diabetes and Endocrinology, 7(5), pp. 344-355. (doi: 10.1016/S2213-8587(19)30068-3) (PMID:30852132)

Taylor, R. et al. (2018) Clinical and metabolic features of the randomised controlled Diabetes Remission Clinical Trial (DiRECT) cohort. Diabetologia, 61(3), pp. 589-598. (doi: 10.1007/s00125-017-4503-0) (PMID:29188339)

Lean, M. E.J. et al. (2018) Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial. Lancet, 391(10120), pp. 541-551. (doi: 10.1016/S0140-6736(17)33102-1) (PMID:29221645)

Leslie, W. S. et al. (2016) The Diabetes Remission Clinical Trial (DiRECT): protocol for a cluster randomised trial. BMC Family Practice, 17(1), (doi: 10.1186/s12875-016-0406-2) (PMID:26879684) (PMCID:PMC4754868)