Ms Louise Mccombie
- Affiliate (School of Medicine, Dentistry & Nursing)
email:
Louise.Mccombie@glasgow.ac.uk
School of Medicine, Dentistry & Nursing, Royal Infirmary Site
Publications
2025
Sharma, V. et al. (2025) A 1-year weight management program for difficult-to-treat asthma with obesity: a randomized controlled study. Chest, 167(1), pp. 42-53. (doi: 10.1016/j.chest.2024.09.042) (PMID:39427706) (PMCID:PMC11752128)
2024
Pugh, J. E. et al. (2024) Increase in colonic PRopionate as a method of prEVENTing weight gain over 12 months in adults aged 20–40 years (iPREVENT): a multi-centre, double-blind, randomised, parallel-group trial. EClinicalMedicine, 76, 102844. (doi: 10.1016/j.eclinm.2024.102844) (PMID:39391015) (PMCID:PMC11466568)
Lean, M. E.J. et al. (2024) 5-year follow-up of the randomised Diabetes Remission Clinical Trial (DiRECT) of continued support for weight loss maintenance in the UK: an extension study. Lancet Diabetes and Endocrinology, 12(4), pp. 233-246. (doi: 10.1016/S2213-8587(23)00385-6) (PMID:38423026)
2023
Sharma, Varun, Ricketts, Helen Clare, McCombie, Louise, Brosnahan, Naomi ORCID: https://orcid.org/0000-0002-3354-1060, Crawford, Luisa, Slaughter, Lesley, Goodfellow, Anna, Lean, Michael E.J.
ORCID: https://orcid.org/0000-0003-2216-0083 and Cowan, Douglas C.
ORCID: https://orcid.org/0000-0001-7297-9041
(2023)
A total diet replacement weight management programme for difficult-to-treat asthma associated with obesity: a randomised controlled feasibility trial.
Chest, 163(5),
pp. 1026-1037.
(doi: 10.1016/j.chest.2023.01.015)
(PMID:36649753)
Cassidy, S. et al. (2023) Physical activity, inactivity and sleep during the Diabetes Remission Clinical Trial (DiRECT). Diabetic Medicine, 40(3), e15010. (doi: 10.1111/dme.15010) (PMID:36398460)
Sattar, Naveed ORCID: https://orcid.org/0000-0002-1604-2593, Welsh, Paul
ORCID: https://orcid.org/0000-0002-7970-3643, Leslie, Wilma S., Thom, George
ORCID: https://orcid.org/0000-0002-8871-9524, McCombie, Louise, Brosnahan, Naomi
ORCID: https://orcid.org/0000-0002-3354-1060, Richardson, Janice
ORCID: https://orcid.org/0000-0002-8207-0891, Gill, Jason M. R.
ORCID: https://orcid.org/0000-0003-3615-0986, Crawford, Luisa and Lean, Michael E. J.
ORCID: https://orcid.org/0000-0003-2216-0083
(2023)
Dietary weight-management for type 2 diabetes remissions in South Asians: the South Asian diabetes remission randomised trial for proof-of-concept and feasibility (STANDby).
Lancet Regional Health – Southeast Asia, 9,
100111.
(doi: 10.1016/j.lansea.2022.100111)
(PMID:36777452)
(PMCID:PMC9904218)
2022
Pugh, J. E. et al. (2022) Increase in colonic PRopionate as a method of prEVENTing weight gain in adults aged 20–40 years (iPREVENT): a multi-centre, double-blind, randomised, parallel-group study to investigate the efficacy of inulin-propionate ester versus inulin (control) in the prevention of weight gain over 12 months. F1000Research, (doi: 10.12688/f1000research.125950.1)
Lean, Mike ORCID: https://orcid.org/0000-0003-2216-0083, McCombie, Louise and Xin, Yiqiao
ORCID: https://orcid.org/0000-0001-5856-3103
(2022)
Forget polypharmacy for type 2 diabetes! Weight management is a better investment.
Nephrology Dialysis Transplantation, 37(5),
pp. 844-846.
(doi: 10.1093/ndt/gfaa250)
(PMID:33263751)
Rehackova, Lucia, Taylor, Roy, Lean, Mike ORCID: https://orcid.org/0000-0003-2216-0083, Barnes, Alison, McCombie, Louise, Thom, George
ORCID: https://orcid.org/0000-0002-8871-9524, Brosnahan, Naomi
ORCID: https://orcid.org/0000-0002-3354-1060, Leslie, Wilma S. and Sniehotta, Falko F.
(2022)
Delivering the Diabetes Remission Clinical Trial (DiRECT) in primary care: experiences of healthcare professionals.
Diabetic Medicine, 39(3),
e14752.
(doi: 10.1111/dme.14752)
(PMID:34837259)
Rehackova, L. et al. (2022) Participant experiences in the Diabetes REmission Clinical Trial (DiRECT). Diabetic Medicine, 39(1), e14689. (doi: 10.1111/dme.14689) (PMID:34519099)
2021
Leslie, W. S. et al. (2021) Antihypertensive medication needs and blood pressure control with weight loss in the Diabetes Remission Clinical Trial (DiRECT). Diabetologia, 64(9), pp. 1927-1938. (doi: 10.1007/s00125-021-05471-x) (PMID:34056684)
Thom, G. et al. (2021) Predictors of type 2 diabetes in the Diabetes Remission Clinical Trial (DiRECT). Diabetic Medicine, 38(8), e14395. (doi: 10.1111/dme.14395) (PMID:32870520)
Brosnahan, Naomi ORCID: https://orcid.org/0000-0002-3354-1060, Leslie, Wilma, McCombie, Louise, Barnes, Alison, Thom, George
ORCID: https://orcid.org/0000-0002-8871-9524, McConnachie, Alex
ORCID: https://orcid.org/0000-0002-7262-7000, Messow, Claudia Martina
ORCID: https://orcid.org/0000-0003-0082-9946, Sattar, Naveed
ORCID: https://orcid.org/0000-0002-1604-2593, Taylor, Roy and Lean, Michael E.J.
ORCID: https://orcid.org/0000-0003-2216-0083
(2021)
Brief formula low‐energy‐diet for relapse management during weight loss maintenance in the Diabetes Remission Clinical Trial (DiRECT).
Journal of Human Nutrition and Dietetics, 34(3),
pp. 472-479.
(doi: 10.1111/jhn.12839)
(PMID:33406285)
Thom, G. et al. (2021) Weight loss induced increase in fasting ghrelin concentration is a predictor of weight regain: evidence from the Diabetes Remission Clinical Trial. Diabetes, Obesity and Metabolism, 23(3), pp. 711-719. (doi: 10.1111/dom.14274) (PMID:33369058)
2020
Xin, Yiqiao ORCID: https://orcid.org/0000-0001-5856-3103, Davies, Andrew, Briggs, Andrew
ORCID: https://orcid.org/0000-0002-0777-1997, McCombie, Louise, Messow, C. Martina
ORCID: https://orcid.org/0000-0003-0082-9946, Grieve, Eleanor
ORCID: https://orcid.org/0000-0002-4115-2882, Leslie, Wilma S., Taylor, Roy and Lean, Michael E.J.
ORCID: https://orcid.org/0000-0003-2216-0083
(2020)
Type 2 diabetes remission: 2 year within-trial and lifetime-horizon cost-effectiveness of the Diabetes Remission Clinical Trial (DiRECT)/Counterweight-Plus weight management programme.
Diabetologia, 63,
pp. 2112-2122.
(doi: 10.1007/s00125-020-05224-2)
(PMID:32776237)
(PMCID:PMC7476973)
2019
Lean, Mike ORCID: https://orcid.org/0000-0003-2216-0083, McCombie, Louise and McSorely, Joe
(2019)
Trends in type 2 diabetes.
British Medical Journal, 366,
l5407.
(doi: 10.1136/bmj.l5407)
(PMID:31511237)
McCombie, L., Brosnahan, N. ORCID: https://orcid.org/0000-0002-3354-1060, Ross, H., Bell-Higgs, A., Govan, L. and Lean, M.E.J.
ORCID: https://orcid.org/0000-0003-2216-0083
(2019)
Filling the intervention gap: service evaluation of an intensive nonsurgical weight management programme for severe and complex obesity.
Journal of Human Nutrition and Dietetics, 32(3),
pp. 329-337.
(doi: 10.1111/jhn.12611)
(PMID:30565772)
Xin, Yiqiao ORCID: https://orcid.org/0000-0001-5856-3103, Davies, Andrew, McCombie, Louise, Briggs, Andrew
ORCID: https://orcid.org/0000-0002-0777-1997, Messow, C.-Martina
ORCID: https://orcid.org/0000-0003-0082-9946, Grieve, Eleanor
ORCID: https://orcid.org/0000-0002-4115-2882, Leslie, Wilma S., Taylor, Roy and Lean, Michael E.J.
ORCID: https://orcid.org/0000-0003-2216-0083
(2019)
Within-trial cost and 1-year cost-effectiveness of the DiRECT/Counterweight-Plus weight-management programme to achieve remission of type 2 diabetes.
Lancet Diabetes and Endocrinology, 7(3),
pp. 169-172.
(doi: 10.1016/S2213-8587(18)30346-2)
(PMID:30581081)
Angelopoulou, Kleopatra, Leslie, Wilma, , ORCID: https://orcid.org/0000-0003-2216-0083 and
(2019)
Diabetes and travel insurance costs: let's talk about remission.
Practical Diabetes, 36(1),
pp. 20-21.
(doi: 10.1002/pdi.2205)
2018
McCombie, Louise and Grieve, Eleanor ORCID: https://orcid.org/0000-0002-4115-2882
(2018)
Economic cost of obesity and the
cost‐effectiveness of weight management.
In: Hankey, Catherine and Whelan, Kevin (eds.)
Advanced Nutrition and Dietetics in Obesity.
John Wiley & Sons, Ltd, pp. 252-259.
ISBN 9780470670767
(doi: 10.1002/9781118857991.ch4)
2017
McCombie, Louise, Leslie, Wilma, Taylor, Roy, Kennon, Brian, Sattar, Naveed ORCID: https://orcid.org/0000-0002-1604-2593 and Lean, Mike E.J.
ORCID: https://orcid.org/0000-0003-2216-0083
(2017)
Beating type 2 diabetes into remission.
British Medical Journal, 358,
j4030.
(doi: 10.1136/bmj.j4030)
(PMID:28903916)
2015
McCombie, Louise, Lean, Michael E.J. ORCID: https://orcid.org/0000-0003-2216-0083 and Tigbe, William W.
(2015)
Cost-effectiveness of obesity treatment.
Medicine, 43(2),
pp. 104-107.
(doi: 10.1016/j.mpmed.2014.11.007)
Articles
Sharma, V. et al. (2025) A 1-year weight management program for difficult-to-treat asthma with obesity: a randomized controlled study. Chest, 167(1), pp. 42-53. (doi: 10.1016/j.chest.2024.09.042) (PMID:39427706) (PMCID:PMC11752128)
Pugh, J. E. et al. (2024) Increase in colonic PRopionate as a method of prEVENTing weight gain over 12 months in adults aged 20–40 years (iPREVENT): a multi-centre, double-blind, randomised, parallel-group trial. EClinicalMedicine, 76, 102844. (doi: 10.1016/j.eclinm.2024.102844) (PMID:39391015) (PMCID:PMC11466568)
Lean, M. E.J. et al. (2024) 5-year follow-up of the randomised Diabetes Remission Clinical Trial (DiRECT) of continued support for weight loss maintenance in the UK: an extension study. Lancet Diabetes and Endocrinology, 12(4), pp. 233-246. (doi: 10.1016/S2213-8587(23)00385-6) (PMID:38423026)
Sharma, Varun, Ricketts, Helen Clare, McCombie, Louise, Brosnahan, Naomi ORCID: https://orcid.org/0000-0002-3354-1060, Crawford, Luisa, Slaughter, Lesley, Goodfellow, Anna, Lean, Michael E.J.
ORCID: https://orcid.org/0000-0003-2216-0083 and Cowan, Douglas C.
ORCID: https://orcid.org/0000-0001-7297-9041
(2023)
A total diet replacement weight management programme for difficult-to-treat asthma associated with obesity: a randomised controlled feasibility trial.
Chest, 163(5),
pp. 1026-1037.
(doi: 10.1016/j.chest.2023.01.015)
(PMID:36649753)
Cassidy, S. et al. (2023) Physical activity, inactivity and sleep during the Diabetes Remission Clinical Trial (DiRECT). Diabetic Medicine, 40(3), e15010. (doi: 10.1111/dme.15010) (PMID:36398460)
Sattar, Naveed ORCID: https://orcid.org/0000-0002-1604-2593, Welsh, Paul
ORCID: https://orcid.org/0000-0002-7970-3643, Leslie, Wilma S., Thom, George
ORCID: https://orcid.org/0000-0002-8871-9524, McCombie, Louise, Brosnahan, Naomi
ORCID: https://orcid.org/0000-0002-3354-1060, Richardson, Janice
ORCID: https://orcid.org/0000-0002-8207-0891, Gill, Jason M. R.
ORCID: https://orcid.org/0000-0003-3615-0986, Crawford, Luisa and Lean, Michael E. J.
ORCID: https://orcid.org/0000-0003-2216-0083
(2023)
Dietary weight-management for type 2 diabetes remissions in South Asians: the South Asian diabetes remission randomised trial for proof-of-concept and feasibility (STANDby).
Lancet Regional Health – Southeast Asia, 9,
100111.
(doi: 10.1016/j.lansea.2022.100111)
(PMID:36777452)
(PMCID:PMC9904218)
Pugh, J. E. et al. (2022) Increase in colonic PRopionate as a method of prEVENTing weight gain in adults aged 20–40 years (iPREVENT): a multi-centre, double-blind, randomised, parallel-group study to investigate the efficacy of inulin-propionate ester versus inulin (control) in the prevention of weight gain over 12 months. F1000Research, (doi: 10.12688/f1000research.125950.1)
Lean, Mike ORCID: https://orcid.org/0000-0003-2216-0083, McCombie, Louise and Xin, Yiqiao
ORCID: https://orcid.org/0000-0001-5856-3103
(2022)
Forget polypharmacy for type 2 diabetes! Weight management is a better investment.
Nephrology Dialysis Transplantation, 37(5),
pp. 844-846.
(doi: 10.1093/ndt/gfaa250)
(PMID:33263751)
Rehackova, Lucia, Taylor, Roy, Lean, Mike ORCID: https://orcid.org/0000-0003-2216-0083, Barnes, Alison, McCombie, Louise, Thom, George
ORCID: https://orcid.org/0000-0002-8871-9524, Brosnahan, Naomi
ORCID: https://orcid.org/0000-0002-3354-1060, Leslie, Wilma S. and Sniehotta, Falko F.
(2022)
Delivering the Diabetes Remission Clinical Trial (DiRECT) in primary care: experiences of healthcare professionals.
Diabetic Medicine, 39(3),
e14752.
(doi: 10.1111/dme.14752)
(PMID:34837259)
Rehackova, L. et al. (2022) Participant experiences in the Diabetes REmission Clinical Trial (DiRECT). Diabetic Medicine, 39(1), e14689. (doi: 10.1111/dme.14689) (PMID:34519099)
Leslie, W. S. et al. (2021) Antihypertensive medication needs and blood pressure control with weight loss in the Diabetes Remission Clinical Trial (DiRECT). Diabetologia, 64(9), pp. 1927-1938. (doi: 10.1007/s00125-021-05471-x) (PMID:34056684)
Thom, G. et al. (2021) Predictors of type 2 diabetes in the Diabetes Remission Clinical Trial (DiRECT). Diabetic Medicine, 38(8), e14395. (doi: 10.1111/dme.14395) (PMID:32870520)
Brosnahan, Naomi ORCID: https://orcid.org/0000-0002-3354-1060, Leslie, Wilma, McCombie, Louise, Barnes, Alison, Thom, George
ORCID: https://orcid.org/0000-0002-8871-9524, McConnachie, Alex
ORCID: https://orcid.org/0000-0002-7262-7000, Messow, Claudia Martina
ORCID: https://orcid.org/0000-0003-0082-9946, Sattar, Naveed
ORCID: https://orcid.org/0000-0002-1604-2593, Taylor, Roy and Lean, Michael E.J.
ORCID: https://orcid.org/0000-0003-2216-0083
(2021)
Brief formula low‐energy‐diet for relapse management during weight loss maintenance in the Diabetes Remission Clinical Trial (DiRECT).
Journal of Human Nutrition and Dietetics, 34(3),
pp. 472-479.
(doi: 10.1111/jhn.12839)
(PMID:33406285)
Thom, G. et al. (2021) Weight loss induced increase in fasting ghrelin concentration is a predictor of weight regain: evidence from the Diabetes Remission Clinical Trial. Diabetes, Obesity and Metabolism, 23(3), pp. 711-719. (doi: 10.1111/dom.14274) (PMID:33369058)
Xin, Yiqiao ORCID: https://orcid.org/0000-0001-5856-3103, Davies, Andrew, Briggs, Andrew
ORCID: https://orcid.org/0000-0002-0777-1997, McCombie, Louise, Messow, C. Martina
ORCID: https://orcid.org/0000-0003-0082-9946, Grieve, Eleanor
ORCID: https://orcid.org/0000-0002-4115-2882, Leslie, Wilma S., Taylor, Roy and Lean, Michael E.J.
ORCID: https://orcid.org/0000-0003-2216-0083
(2020)
Type 2 diabetes remission: 2 year within-trial and lifetime-horizon cost-effectiveness of the Diabetes Remission Clinical Trial (DiRECT)/Counterweight-Plus weight management programme.
Diabetologia, 63,
pp. 2112-2122.
(doi: 10.1007/s00125-020-05224-2)
(PMID:32776237)
(PMCID:PMC7476973)
Lean, Mike ORCID: https://orcid.org/0000-0003-2216-0083, McCombie, Louise and McSorely, Joe
(2019)
Trends in type 2 diabetes.
British Medical Journal, 366,
l5407.
(doi: 10.1136/bmj.l5407)
(PMID:31511237)
McCombie, L., Brosnahan, N. ORCID: https://orcid.org/0000-0002-3354-1060, Ross, H., Bell-Higgs, A., Govan, L. and Lean, M.E.J.
ORCID: https://orcid.org/0000-0003-2216-0083
(2019)
Filling the intervention gap: service evaluation of an intensive nonsurgical weight management programme for severe and complex obesity.
Journal of Human Nutrition and Dietetics, 32(3),
pp. 329-337.
(doi: 10.1111/jhn.12611)
(PMID:30565772)
Xin, Yiqiao ORCID: https://orcid.org/0000-0001-5856-3103, Davies, Andrew, McCombie, Louise, Briggs, Andrew
ORCID: https://orcid.org/0000-0002-0777-1997, Messow, C.-Martina
ORCID: https://orcid.org/0000-0003-0082-9946, Grieve, Eleanor
ORCID: https://orcid.org/0000-0002-4115-2882, Leslie, Wilma S., Taylor, Roy and Lean, Michael E.J.
ORCID: https://orcid.org/0000-0003-2216-0083
(2019)
Within-trial cost and 1-year cost-effectiveness of the DiRECT/Counterweight-Plus weight-management programme to achieve remission of type 2 diabetes.
Lancet Diabetes and Endocrinology, 7(3),
pp. 169-172.
(doi: 10.1016/S2213-8587(18)30346-2)
(PMID:30581081)
Angelopoulou, Kleopatra, Leslie, Wilma, , ORCID: https://orcid.org/0000-0003-2216-0083 and
(2019)
Diabetes and travel insurance costs: let's talk about remission.
Practical Diabetes, 36(1),
pp. 20-21.
(doi: 10.1002/pdi.2205)
McCombie, Louise, Leslie, Wilma, Taylor, Roy, Kennon, Brian, Sattar, Naveed ORCID: https://orcid.org/0000-0002-1604-2593 and Lean, Mike E.J.
ORCID: https://orcid.org/0000-0003-2216-0083
(2017)
Beating type 2 diabetes into remission.
British Medical Journal, 358,
j4030.
(doi: 10.1136/bmj.j4030)
(PMID:28903916)
McCombie, Louise, Lean, Michael E.J. ORCID: https://orcid.org/0000-0003-2216-0083 and Tigbe, William W.
(2015)
Cost-effectiveness of obesity treatment.
Medicine, 43(2),
pp. 104-107.
(doi: 10.1016/j.mpmed.2014.11.007)
Book Sections
McCombie, Louise and Grieve, Eleanor ORCID: https://orcid.org/0000-0002-4115-2882
(2018)
Economic cost of obesity and the
cost‐effectiveness of weight management.
In: Hankey, Catherine and Whelan, Kevin (eds.)
Advanced Nutrition and Dietetics in Obesity.
John Wiley & Sons, Ltd, pp. 252-259.
ISBN 9780470670767
(doi: 10.1002/9781118857991.ch4)