Professor Iain Johnstone

  • Professor (Life Sciences Biomolecular Sciences)
  • Associate (Institute of Molecular Cell & Systems Biology)

telephone: 01413302844
email: Iain.Johnstone@glasgow.ac.uk

Personal assistant: Miss Katie Goldie
telephone: 01413304063
email: Katie.Goldie@glasgow.ac.uk

Research interests

  • Tissue specific control of the cell cycle in C. elegans
  • Collagen biogenesis and the recognition and processing of mutant collagens in C. elegans

To read more about Dr Johnstone's research interests click here


Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Using C. elegans to identify novel genetic modifiers of collagen IV mutations that cause stroke
    Tenovus Scotland
    2015 - 2015
     
  • Shedding light on oxidative stress: Identifying factors modulating the redox balance in the endoplasmic reticulum of Caenorhabditis elegans.
    Biotechnology and Biological Sciences Research Council
    2013 - 2016
     
  • Identifying factors modulating the redox balance in the endoplasmic reticulum using the model system Carnorhabditis elegans (ISSF Catalyst Fund)
    Wellcome Trust
    2011 - 2014
     
  • A genetic analysis of the response to the presence of glycine substitution mutant collagen in C. elegans
    Medical Research Council
    2006 - 2009
     
  • Tissue specific control of the cell cycle in C. elegans
    Medical Research Council
    2005 - 2008
     
  • A genetic analysis of collagen biogenesis in C.elegans
    Wellcome Trust
    2005 - 2007
     
  • Molecular genetics and biochemistry of parasites
    Medical Research Council
    2004 - 2009
     

Additional information

Grant Advisory Board

  • 2006 - 2009: MRC - College of Experts
  • 1998 - 2003: MRC - Member of Advisory Board

Invited International Presentations

  • 2005: Glasgow, Scotland - Bioscience - co-organiser and co-chair mini symposium "Systematic Functional Analysis of Genomes"
  • 2002: Italy - Invited Speaker at the European Worm Meeting,

Research Fellowship

  • 2004 - 1998: MRC Career Development Fellowship
  • 1998 - 2003: MRC Senior Fellowship

Publications

List by: Type | Date

Jump to: 2010 | 2009 | 2008 | 2007 | 2003 | 2002 | 2001 | 2000 | 1999 | 1998 | 1997 | 1996 | 1994 | 1992 | 1991 | 1990 | 1985
Number of items: 28.

2010

Segref, A., Cabello, J., Clucas, C., Schnabel, R. and Johnstone, I. L. (2010) Fate specification and tissue-specific cell cycle control of the Caenorhabditis elegans intestine. Molecular Biology of the Cell, 21(5), pp. 725-738. (doi:10.1091/mbc.E09-04-0268)

2009

Thein, M. C., Winter, A. D., Stepek, G., McCormack, G., Stapleton, G., Johnstone, I. L. and Page, A. P. (2009) Combined extracellular matrix cross-linking activity of the peroxidase MLT-7 and the dual oxidase BLI-3 is critical for post-embryonic viability in Caenorhabditis elegans. Journal of Biological Chemistry, 284(26), pp. 17549-17563. (doi:10.1074/jbc.M900831200)

2008

Longman, D., Arrisi, P., Johnstone, I.L. and Cáceres, J.F. (2008) Nonsense‐mediated mRNA decay in Caenorhabditis elegans. In: RNA Turnover in Eukaryotes: Analysis of Specialized and Quality Control RNA Decay Pathways. Series: Methods in Enzymology, 449. Academic Press, p. 149. ISBN 9780123745842 (doi:10.1016/S0076-6879(08)02407-5)

2007

Longman, D., Plasterk, R., Johnstone, I. and Caceres, J. (2007) Mechanistic insights and identification of two novel factors in the C-elegans NMD pathway. Genes and Development, 21, pp. 1075-1085. (doi:10.1101/gad.417707)

2003

Longman, D., Johnstone, I. L. and Caceres, J. F. (2003) The Ref/Aly proteins are dispensable for mRNA export and development in Caenorhabditis elegans. RNA, 9, pp. 881-891. (doi:10.1261/rna.5420503)

McCracken, S., Longman, D., Johnstone, I., Caceres, J. and Blencowe, B. (2003) An evolutionarily conserved role for SRm160 in 3 '-end processing that functions independently of exon junction complex formation. Journal of Biological Chemistry, 278, pp. 44153-44160. (doi:10.1074/jbc.M306856200)

McMahon, L., Muriel, J., Roberts, B., Quinn, M. and Johnstone, I. (2003) Two sets of interacting collagens form functionally distinct substructures within a Caenorhabditis elegans extracellular matrix. Molecular Biology of the Cell, 14, pp. 1366-1378. (doi:10.1091/mbc.E02-08-0479)

Muriel, J., Brannan, M., Taylor, K., Johnstone, I., Lithgow, G. and Tuckwell, D. (2003) M142.2 (cut-6), a novel Caenorhabditis elegans matrix gene important for dauer body shape. Developmental Biology, 260, pp. 339-351. (doi:10.1016/S0012-1606(03)00237-9)

Roberts, B., Clucas, C. and Johnstone, I. (2003) Loss of SEC-23 in Caenorhabditis elegans causes defects in oogenesis, morphogenesis, and extracellular matrix secretion. Molecular Biology of the Cell, 14, pp. 4414-4426.

Thein, M., McCormack, G., Winter, A., Johnstone, I., Shoemaker, C. and Page, A. (2003) Caenorhabditis elegans exoskeleton collagen COL-19: An adult-specific marker for collagen modification and assembly, and the analysis of organismal morphology. Developmental Dynamics, 226, pp. 523-539. (doi:10.1002/dvdy.10259)

2002

Clucas, C., Cabello, J., Bussing, I., Schnabel, R. and Johnstone, I.L. (2002) Oncogenic potential of a C.elegans cdc25 gene is demonstrated by a gain-of-function allele. EMBO Journal, 21, pp. 665-674.

2001

Longman, D., McGarvey, T., McCracken, S., Johnstone, I., Blencowe, B. and Caceres, J. (2001) Multiple interactions between SRm160 and SR family proteins in enhancer-dependent splicing and development of C-elegans. Current Biology, 11, pp. 1923-1933.

Redmond, D., Clucas, C., Johnstone, I. and Knox, D. (2001) Expression of Haemonchus contortus pepsinogen in Caenorhabditis elegans. Molecular and Biochemical Parasitology, 112, pp. 125-131.

2000

Ozanne, B. W., McGarry, L., Spence, H. J., Johnstone, I., Winnie, J., Meagher, L. and Stapleton, G. (2000) Transcriptional regulation of cell invasion: AP-1 regulation of a multigenic invasion programme. European Journal of Cancer, 36(13), pp. 1640-1648. (doi:10.1016/S0959-8049(00)00175-1) (PMID:10959050)

Longman, D., Johnstone, I. L. and Cáceres, J. F. (2000) Functional characterization of SR and SR-related genes in Caenorhabditis elegans. EMBO Journal, 19(7), pp. 1625-1637. (doi:10.1093/emboj/19.7.1625) (PMID:10747030) (PMCID:PMC310231)

Johnstone, I. L. (2000) Cuticle collagen genes. expression in Caenorhabditis elegans. Trends in Genetics, 16(1), pp. 21-27. (doi:10.1016/S0168-9525(99)01857-0) (PMID:10637627)

1999

Johnstone, I. L. (1999) Molecular biology. In: Hope, I. A. (ed.) Caenorhabditis elegans: a Practical Approach. Series: Practical approach series (213). Oxford University Press: Oxford ; New York, pp. 201-226. ISBN 9780199637386

1998

Britton, C. , McKerrow, J. H. and Johnstone, I. L. (1998) Regulation of the Caenorhabditis elegans gut cysteine protease gene cpr-1: requirement for GATA motifs. Journal of Molecular Biology, 283(1), pp. 15-27. (doi:10.1006/jmbi.1998.2093) (PMID:9761670)

1997

Gilleard, J. S., Barry, J. D. and Johnstone, I. L. (1997) cis regulatory requirements for hypodermal cell-specific expression of the Caenorhabditis elegans cuticle collagen gene dpy-7. Molecular and Cellular Biology, 17(4), pp. 2301-2311. (doi:10.1128/MCB.17.4.2301) (PMID:9121480) (PMCID:PMC232079)

1996

Johnstone, I. L., Shafi, Y., Majeed, A. and Barry, J. D. (1996) Cuticular collagen genes from the parasitic nematode Ostertagia circumcincta. Molecular and Biochemical Parasitology, 80(1), pp. 103-112. (doi:10.1016/0166-6851(96)02682-5) (PMID:8885226)

Johnstone, I. L. and Barry, J. D. (1996) Temporal reiteration of a precise gene expression pattern during nematode development. EMBO Journal, 15(14), pp. 3633-3639. (PMID:8670866) (PMCID:PMC451985)

Larminie, C. G.C. and Johnstone, I. L. (1996) Isolation and characterization of four developmentally regulated cathepsin B-like cysteine protease genes from the nematode Caenorhabditis elegans. DNA and Cell Biology, 15(1), pp. 75-82. (doi:10.1089/dna.1996.15.75) (PMID:8561899)

1994

Johnstone, I. L. (1994) The cuticle of the nematode Caenorhabditis elegans: a complex collagen structure. BioEssays, 16(3), pp. 171-178. (doi:10.1002/bies.950160307) (PMID:8166670)

1992

Johnstone, I.L., Shafi, Y. and Barry, J.D. (1992) Molecular analysis of mutations in the Caenorhabditis elegans collagen gene dpy-7. EMBO Journal, 11(11), pp. 3857-3863. (PMID:1396579) (PMCID:PMC556895)

1991

Gems, D., Johnstone, I. L. and Clutterbuck, A. J. (1991) An autonomously replicating plasmid transforms Aspergillus nidulans at high frequency. Gene, 98(1), pp. 61-67. (doi:10.1016/0378-1119(91)90104-J) (PMID:2013411)

1990

Johnstone, I.L., McCabe, P.C., Greaves, P., Gurr, S.J., Cole, G.E., Brow, M.A., Unkles, S.E., Clutterbuck, A.J., Kinghorn, J.R. and Innis, M.A. (1990) Isolation and characterisation of the crnA-niiA-niaD gene cluster for nitrate assimilation in Aspergillus nidulans. Gene, 90(2), pp. 181-192. (doi:10.1016/0378-1119(90)90178-T) (PMID:2205530)

1985

Johnstone, I. (1985) Transformation of Aspergillus nidulans. Microbiological Sciences, 2(10), pp. 307-311. (PMID:3939985)

Johnstone, I.L., Hughes, S.G. and Clutterbuck, A.J. (1985) Cloning an Aspergillus nidulans developmental gene by transformation. EMBO Journal, 4(5), pp. 1307-1311. (PMID:3891328) (PMCID:PMC554341)

This list was generated on Sun Dec 16 16:55:59 2018 GMT.
Number of items: 28.

Articles

Segref, A., Cabello, J., Clucas, C., Schnabel, R. and Johnstone, I. L. (2010) Fate specification and tissue-specific cell cycle control of the Caenorhabditis elegans intestine. Molecular Biology of the Cell, 21(5), pp. 725-738. (doi:10.1091/mbc.E09-04-0268)

Thein, M. C., Winter, A. D., Stepek, G., McCormack, G., Stapleton, G., Johnstone, I. L. and Page, A. P. (2009) Combined extracellular matrix cross-linking activity of the peroxidase MLT-7 and the dual oxidase BLI-3 is critical for post-embryonic viability in Caenorhabditis elegans. Journal of Biological Chemistry, 284(26), pp. 17549-17563. (doi:10.1074/jbc.M900831200)

Longman, D., Plasterk, R., Johnstone, I. and Caceres, J. (2007) Mechanistic insights and identification of two novel factors in the C-elegans NMD pathway. Genes and Development, 21, pp. 1075-1085. (doi:10.1101/gad.417707)

Longman, D., Johnstone, I. L. and Caceres, J. F. (2003) The Ref/Aly proteins are dispensable for mRNA export and development in Caenorhabditis elegans. RNA, 9, pp. 881-891. (doi:10.1261/rna.5420503)

McCracken, S., Longman, D., Johnstone, I., Caceres, J. and Blencowe, B. (2003) An evolutionarily conserved role for SRm160 in 3 '-end processing that functions independently of exon junction complex formation. Journal of Biological Chemistry, 278, pp. 44153-44160. (doi:10.1074/jbc.M306856200)

McMahon, L., Muriel, J., Roberts, B., Quinn, M. and Johnstone, I. (2003) Two sets of interacting collagens form functionally distinct substructures within a Caenorhabditis elegans extracellular matrix. Molecular Biology of the Cell, 14, pp. 1366-1378. (doi:10.1091/mbc.E02-08-0479)

Muriel, J., Brannan, M., Taylor, K., Johnstone, I., Lithgow, G. and Tuckwell, D. (2003) M142.2 (cut-6), a novel Caenorhabditis elegans matrix gene important for dauer body shape. Developmental Biology, 260, pp. 339-351. (doi:10.1016/S0012-1606(03)00237-9)

Roberts, B., Clucas, C. and Johnstone, I. (2003) Loss of SEC-23 in Caenorhabditis elegans causes defects in oogenesis, morphogenesis, and extracellular matrix secretion. Molecular Biology of the Cell, 14, pp. 4414-4426.

Thein, M., McCormack, G., Winter, A., Johnstone, I., Shoemaker, C. and Page, A. (2003) Caenorhabditis elegans exoskeleton collagen COL-19: An adult-specific marker for collagen modification and assembly, and the analysis of organismal morphology. Developmental Dynamics, 226, pp. 523-539. (doi:10.1002/dvdy.10259)

Clucas, C., Cabello, J., Bussing, I., Schnabel, R. and Johnstone, I.L. (2002) Oncogenic potential of a C.elegans cdc25 gene is demonstrated by a gain-of-function allele. EMBO Journal, 21, pp. 665-674.

Longman, D., McGarvey, T., McCracken, S., Johnstone, I., Blencowe, B. and Caceres, J. (2001) Multiple interactions between SRm160 and SR family proteins in enhancer-dependent splicing and development of C-elegans. Current Biology, 11, pp. 1923-1933.

Redmond, D., Clucas, C., Johnstone, I. and Knox, D. (2001) Expression of Haemonchus contortus pepsinogen in Caenorhabditis elegans. Molecular and Biochemical Parasitology, 112, pp. 125-131.

Ozanne, B. W., McGarry, L., Spence, H. J., Johnstone, I., Winnie, J., Meagher, L. and Stapleton, G. (2000) Transcriptional regulation of cell invasion: AP-1 regulation of a multigenic invasion programme. European Journal of Cancer, 36(13), pp. 1640-1648. (doi:10.1016/S0959-8049(00)00175-1) (PMID:10959050)

Longman, D., Johnstone, I. L. and Cáceres, J. F. (2000) Functional characterization of SR and SR-related genes in Caenorhabditis elegans. EMBO Journal, 19(7), pp. 1625-1637. (doi:10.1093/emboj/19.7.1625) (PMID:10747030) (PMCID:PMC310231)

Johnstone, I. L. (2000) Cuticle collagen genes. expression in Caenorhabditis elegans. Trends in Genetics, 16(1), pp. 21-27. (doi:10.1016/S0168-9525(99)01857-0) (PMID:10637627)

Britton, C. , McKerrow, J. H. and Johnstone, I. L. (1998) Regulation of the Caenorhabditis elegans gut cysteine protease gene cpr-1: requirement for GATA motifs. Journal of Molecular Biology, 283(1), pp. 15-27. (doi:10.1006/jmbi.1998.2093) (PMID:9761670)

Gilleard, J. S., Barry, J. D. and Johnstone, I. L. (1997) cis regulatory requirements for hypodermal cell-specific expression of the Caenorhabditis elegans cuticle collagen gene dpy-7. Molecular and Cellular Biology, 17(4), pp. 2301-2311. (doi:10.1128/MCB.17.4.2301) (PMID:9121480) (PMCID:PMC232079)

Johnstone, I. L., Shafi, Y., Majeed, A. and Barry, J. D. (1996) Cuticular collagen genes from the parasitic nematode Ostertagia circumcincta. Molecular and Biochemical Parasitology, 80(1), pp. 103-112. (doi:10.1016/0166-6851(96)02682-5) (PMID:8885226)

Johnstone, I. L. and Barry, J. D. (1996) Temporal reiteration of a precise gene expression pattern during nematode development. EMBO Journal, 15(14), pp. 3633-3639. (PMID:8670866) (PMCID:PMC451985)

Larminie, C. G.C. and Johnstone, I. L. (1996) Isolation and characterization of four developmentally regulated cathepsin B-like cysteine protease genes from the nematode Caenorhabditis elegans. DNA and Cell Biology, 15(1), pp. 75-82. (doi:10.1089/dna.1996.15.75) (PMID:8561899)

Johnstone, I. L. (1994) The cuticle of the nematode Caenorhabditis elegans: a complex collagen structure. BioEssays, 16(3), pp. 171-178. (doi:10.1002/bies.950160307) (PMID:8166670)

Johnstone, I.L., Shafi, Y. and Barry, J.D. (1992) Molecular analysis of mutations in the Caenorhabditis elegans collagen gene dpy-7. EMBO Journal, 11(11), pp. 3857-3863. (PMID:1396579) (PMCID:PMC556895)

Gems, D., Johnstone, I. L. and Clutterbuck, A. J. (1991) An autonomously replicating plasmid transforms Aspergillus nidulans at high frequency. Gene, 98(1), pp. 61-67. (doi:10.1016/0378-1119(91)90104-J) (PMID:2013411)

Johnstone, I.L., McCabe, P.C., Greaves, P., Gurr, S.J., Cole, G.E., Brow, M.A., Unkles, S.E., Clutterbuck, A.J., Kinghorn, J.R. and Innis, M.A. (1990) Isolation and characterisation of the crnA-niiA-niaD gene cluster for nitrate assimilation in Aspergillus nidulans. Gene, 90(2), pp. 181-192. (doi:10.1016/0378-1119(90)90178-T) (PMID:2205530)

Johnstone, I. (1985) Transformation of Aspergillus nidulans. Microbiological Sciences, 2(10), pp. 307-311. (PMID:3939985)

Johnstone, I.L., Hughes, S.G. and Clutterbuck, A.J. (1985) Cloning an Aspergillus nidulans developmental gene by transformation. EMBO Journal, 4(5), pp. 1307-1311. (PMID:3891328) (PMCID:PMC554341)

Book Sections

Longman, D., Arrisi, P., Johnstone, I.L. and Cáceres, J.F. (2008) Nonsense‐mediated mRNA decay in Caenorhabditis elegans. In: RNA Turnover in Eukaryotes: Analysis of Specialized and Quality Control RNA Decay Pathways. Series: Methods in Enzymology, 449. Academic Press, p. 149. ISBN 9780123745842 (doi:10.1016/S0076-6879(08)02407-5)

Johnstone, I. L. (1999) Molecular biology. In: Hope, I. A. (ed.) Caenorhabditis elegans: a Practical Approach. Series: Practical approach series (213). Oxford University Press: Oxford ; New York, pp. 201-226. ISBN 9780199637386

This list was generated on Sun Dec 16 16:55:59 2018 GMT.