Dr Wael Kamel
- Research Associate (Virology)
Publications
2025
Wilson, A. et al. (2025) Uukuniemi virus infection causes a pervasive remodelling of the RNA-binding proteome in tick cells. PLoS Pathogens, 21(8), e1013393. (doi: 10.1371/journal.ppat.1013393) (PMID:40758761) (PMCID:PMC12342294)
Iselin, Louisa, Demyanenko, Yana, Palmalux, Natasha, Embarc Buh, Azman, Kamel, Wael ORCID: https://orcid.org/0000-0002-7625-2648, Simmonds, Peter, Mohammed, Shabaz and Castello, Alfredo
ORCID: https://orcid.org/0000-0002-1499-4662
(2025)
RNA binding regulation is a new dimension in the type I IFN response.
bioRxiv,
(doi: 10.1101/2025.05.30.656608)
Castello, Alfredo ORCID: https://orcid.org/0000-0002-1499-4662 and Kamel, Wael
ORCID: https://orcid.org/0000-0002-7625-2648
(2025)
Nuclear RNA-binding proteins meet cytoplasmic viruses.
RNA, 31(3),
pp. 444-451.
(doi: 10.1261/rna.080313.124)
(PMID:39805659)
(PMCID:PMC11874974)
2024
Kamel, W. et al. (2024) Alphavirus infection triggers selective cytoplasmic translocation of nuclear RBPs with moonlighting antiviral roles. Molecular Cell, 84(24), 4896-4911.e7. (doi: 10.1016/j.molcel.2024.11.015) (PMID:39642884)
Castello, Alfredo ORCID: https://orcid.org/0000-0002-1499-4662, Alvarez, Lucia, Kamel, Wael
ORCID: https://orcid.org/0000-0002-7625-2648, Iselin, Louisa and Hennig, Janosch
(2024)
Exploring the expanding universe of host-virus interactions mediated by viral RNA.
Molecular Cell, 84(19),
pp. 3706-3721.
(doi: 10.1016/j.molcel.2024.08.027)
(PMID:39366356)
2023
Rainey, Stephanie M. ORCID: https://orcid.org/0000-0001-9504-5495, Geoghegan, Vincent, Lefteri, Daniella A.
ORCID: https://orcid.org/0000-0002-9985-4254, Ant, Thomas H., Martinez, Julien
ORCID: https://orcid.org/0000-0001-8210-2921, McNamara, Cameron J., Kamel, Wael
ORCID: https://orcid.org/0000-0002-7625-2648, de Laurent, Zaydah Rolande, Castello, Alfredo
ORCID: https://orcid.org/0000-0002-1499-4662 and Sinkins, Steven P.
ORCID: https://orcid.org/0000-0002-2678-1832
(2023)
Differences in proteome perturbations caused by the Wolbachia strain wAu suggest multiple mechanisms of Wolbachia-mediated antiviral activity.
Scientific Reports, 13,
11737.
(doi: 10.1038/s41598-023-38127-4)
(PMID:37474590)
(PMCID:PMC10359319)
2022
Iselin, Louisa, Palmalux, Natasha, Kamel, Wael ORCID: https://orcid.org/0000-0002-7625-2648, Simmonds, Peter, Mohammed, Shabaz and Castello, Alfredo
ORCID: https://orcid.org/0000-0002-1499-4662
(2022)
Uncovering viral RNA-host cell interactions on a proteome-wide scale.
Trends in Biochemical Sciences, 47(1),
pp. 23-38.
(doi: 10.1016/j.tibs.2021.08.002)
(PMID:34509361)
2019
Kamel, Wael Sayed Saleh Elsayed. Kusjarvi, Göran (2019) Stable RNA molecules. .
Darweesh, Mahmoud, Kamel, Wael ORCID: https://orcid.org/0000-0002-7625-2648, Gavrilin, Mikhail A., Akusjärvi, Göran and Svensson, Catharina
(2019)
Adenovirus VA RNAI blocks ASC oligomerization and inhibits NLRP3 inflammasome activation.
Frontiers in Immunology, 10,
2791.
(doi: 10.3389/fimmu.2019.02791)
(PMID:31849970)
(PMCID:PMC6901988)
2018
Younis, Shady. Kamel, Wael. Akusjarvi, Goran. Andersson, Leif. (2018) Methods for identifying new therapeutic agents. .
Younis, Shady, Kamel, Wael ORCID: https://orcid.org/0000-0002-7625-2648, Falkeborn, Tina, Wang, Hao, Yu, Di, Daniels, Robert, Essand, Magnus, Hinkula, Jorma, Akusjärvi, Göran and Andersson, Leif
(2018)
Multiple nuclear-replicating viruses require the stress-induced protein ZC3H11A for efficient growth.
Proceedings of the National Academy of Sciences of the United States of America, 115(16),
E3808-E3816.
(doi: 10.1073/pnas.1722333115)
(PMID:29610341)
(PMCID:PMC5910864)
2017
Kamel, Wael ORCID: https://orcid.org/0000-0002-7625-2648 and Akusjarvi, Goran
(2017)
An Ago2-associated capped transcriptional start site small RNA suppresses adenovirus DNA replication.
RNA, 23(11),
p. 1700.
(doi: 10.1261/rna.061291.117)
(PMID:28839112)
(PMCID:PMC5648037)
Assadian, Farzaneh, Kamel, Wael ORCID: https://orcid.org/0000-0002-7625-2648, Laurell, Goran, Svensson, Catharina, Punga, Tanel and Akusjarvi, Goran
(2017)
Expression profile of Epstein-Barr virus and human adenovirus small RNAs in tonsillar B and T lymphocytes.
PLoS ONE, 12(5),
e0177275.
(doi: 10.1371/journal.pone.0177275)
(PMID:28542273)
(PMCID:PMC5444648)
Lan, Susan, Kamel, Wael ORCID: https://orcid.org/0000-0002-7625-2648, Punga, Tanel and Akusjarvi, Goran
(2017)
The adenovirus L4-22K protein regulates transcription and RNA splicing via a sequence-specific single-stranded RNA binding.
Nucleic Acids Research, 45(4),
pp. 1731-1742.
(doi: 10.1093/nar/gkw1145)
(PMID:27899607)
(PMCID:PMC5389519)
2015
Inturi, Raviteja, Kamel, Wael ORCID: https://orcid.org/0000-0002-7625-2648, Akusjärvi, Göran and Punga, Tanel
(2015)
Complementation of the human adenovirus type 5 VA RNAI defect by the Vaccinia virus E3L protein and serotype-specific VA RNAIs.
Virology, 485,
pp. 25-35.
(doi: 10.1016/j.virol.2015.07.002)
(PMID:26196231)
Pickl, Julia Maria Anna, Kamel, Wael ORCID: https://orcid.org/0000-0002-7625-2648, Ciftci, Sibel, Punga, Tanel and Akusjärvi, Göran
(2015)
Opposite expression of CYP51A1 and its natural antisense transcript AluCYP51A1 in adenovirus type 37 infected retinal pigmented epithelial cells.
FEBS Letters, 589(12),
pp. 1383-1388.
(doi: 10.1016/j.febslet.2015.04.018)
(PMID:25907535)
2014
Kamel, Wael ORCID: https://orcid.org/0000-0002-7625-2648, Segerman, Bo, Punga, Tanel and Akusjarvi, Goran
(2014)
Small RNA sequence analysis of adenovirus VA RNA-derived miRNAs reveals an unexpected serotype-specific difference in structure and abundance.
PloS ONE, 9(8),
e105746.
(doi: 10.1371/journal.pone.0105746)
(PMID:25144466)
(PMCID:PMC4140831)
2013
Kamel, Wael ORCID: https://orcid.org/0000-0002-7625-2648, Segerman, Bo, Öberg, Daniel, Punga, Tanel and Akusjärvi, Göran
(2013)
The adenovirus VA RNA-derived miRNAs are not essential for lytic virus growth in tissue culture cells.
Nucleic Acids Research, 41(9),
pp. 4802-4812.
(doi: 10.1093/nar/gkt172)
(PMID:23525465)
(PMCID:PMC3643585)
Punga, Tanel, Kamel, Wael ORCID: https://orcid.org/0000-0002-7625-2648 and Akusjärvi, Göran
(2013)
Old and new functions for the adenovirus virus-associated RNAs.
Future Virology, 8(4),
pp. 343-356.
(doi: 10.2217/fvl.13.19)
(PMID:29610341)
(PMCID:PMC5910864)
Articles
Wilson, A. et al. (2025) Uukuniemi virus infection causes a pervasive remodelling of the RNA-binding proteome in tick cells. PLoS Pathogens, 21(8), e1013393. (doi: 10.1371/journal.ppat.1013393) (PMID:40758761) (PMCID:PMC12342294)
Iselin, Louisa, Demyanenko, Yana, Palmalux, Natasha, Embarc Buh, Azman, Kamel, Wael ORCID: https://orcid.org/0000-0002-7625-2648, Simmonds, Peter, Mohammed, Shabaz and Castello, Alfredo
ORCID: https://orcid.org/0000-0002-1499-4662
(2025)
RNA binding regulation is a new dimension in the type I IFN response.
bioRxiv,
(doi: 10.1101/2025.05.30.656608)
Castello, Alfredo ORCID: https://orcid.org/0000-0002-1499-4662 and Kamel, Wael
ORCID: https://orcid.org/0000-0002-7625-2648
(2025)
Nuclear RNA-binding proteins meet cytoplasmic viruses.
RNA, 31(3),
pp. 444-451.
(doi: 10.1261/rna.080313.124)
(PMID:39805659)
(PMCID:PMC11874974)
Kamel, W. et al. (2024) Alphavirus infection triggers selective cytoplasmic translocation of nuclear RBPs with moonlighting antiviral roles. Molecular Cell, 84(24), 4896-4911.e7. (doi: 10.1016/j.molcel.2024.11.015) (PMID:39642884)
Castello, Alfredo ORCID: https://orcid.org/0000-0002-1499-4662, Alvarez, Lucia, Kamel, Wael
ORCID: https://orcid.org/0000-0002-7625-2648, Iselin, Louisa and Hennig, Janosch
(2024)
Exploring the expanding universe of host-virus interactions mediated by viral RNA.
Molecular Cell, 84(19),
pp. 3706-3721.
(doi: 10.1016/j.molcel.2024.08.027)
(PMID:39366356)
Rainey, Stephanie M. ORCID: https://orcid.org/0000-0001-9504-5495, Geoghegan, Vincent, Lefteri, Daniella A.
ORCID: https://orcid.org/0000-0002-9985-4254, Ant, Thomas H., Martinez, Julien
ORCID: https://orcid.org/0000-0001-8210-2921, McNamara, Cameron J., Kamel, Wael
ORCID: https://orcid.org/0000-0002-7625-2648, de Laurent, Zaydah Rolande, Castello, Alfredo
ORCID: https://orcid.org/0000-0002-1499-4662 and Sinkins, Steven P.
ORCID: https://orcid.org/0000-0002-2678-1832
(2023)
Differences in proteome perturbations caused by the Wolbachia strain wAu suggest multiple mechanisms of Wolbachia-mediated antiviral activity.
Scientific Reports, 13,
11737.
(doi: 10.1038/s41598-023-38127-4)
(PMID:37474590)
(PMCID:PMC10359319)
Iselin, Louisa, Palmalux, Natasha, Kamel, Wael ORCID: https://orcid.org/0000-0002-7625-2648, Simmonds, Peter, Mohammed, Shabaz and Castello, Alfredo
ORCID: https://orcid.org/0000-0002-1499-4662
(2022)
Uncovering viral RNA-host cell interactions on a proteome-wide scale.
Trends in Biochemical Sciences, 47(1),
pp. 23-38.
(doi: 10.1016/j.tibs.2021.08.002)
(PMID:34509361)
Darweesh, Mahmoud, Kamel, Wael ORCID: https://orcid.org/0000-0002-7625-2648, Gavrilin, Mikhail A., Akusjärvi, Göran and Svensson, Catharina
(2019)
Adenovirus VA RNAI blocks ASC oligomerization and inhibits NLRP3 inflammasome activation.
Frontiers in Immunology, 10,
2791.
(doi: 10.3389/fimmu.2019.02791)
(PMID:31849970)
(PMCID:PMC6901988)
Younis, Shady, Kamel, Wael ORCID: https://orcid.org/0000-0002-7625-2648, Falkeborn, Tina, Wang, Hao, Yu, Di, Daniels, Robert, Essand, Magnus, Hinkula, Jorma, Akusjärvi, Göran and Andersson, Leif
(2018)
Multiple nuclear-replicating viruses require the stress-induced protein ZC3H11A for efficient growth.
Proceedings of the National Academy of Sciences of the United States of America, 115(16),
E3808-E3816.
(doi: 10.1073/pnas.1722333115)
(PMID:29610341)
(PMCID:PMC5910864)
Kamel, Wael ORCID: https://orcid.org/0000-0002-7625-2648 and Akusjarvi, Goran
(2017)
An Ago2-associated capped transcriptional start site small RNA suppresses adenovirus DNA replication.
RNA, 23(11),
p. 1700.
(doi: 10.1261/rna.061291.117)
(PMID:28839112)
(PMCID:PMC5648037)
Assadian, Farzaneh, Kamel, Wael ORCID: https://orcid.org/0000-0002-7625-2648, Laurell, Goran, Svensson, Catharina, Punga, Tanel and Akusjarvi, Goran
(2017)
Expression profile of Epstein-Barr virus and human adenovirus small RNAs in tonsillar B and T lymphocytes.
PLoS ONE, 12(5),
e0177275.
(doi: 10.1371/journal.pone.0177275)
(PMID:28542273)
(PMCID:PMC5444648)
Lan, Susan, Kamel, Wael ORCID: https://orcid.org/0000-0002-7625-2648, Punga, Tanel and Akusjarvi, Goran
(2017)
The adenovirus L4-22K protein regulates transcription and RNA splicing via a sequence-specific single-stranded RNA binding.
Nucleic Acids Research, 45(4),
pp. 1731-1742.
(doi: 10.1093/nar/gkw1145)
(PMID:27899607)
(PMCID:PMC5389519)
Inturi, Raviteja, Kamel, Wael ORCID: https://orcid.org/0000-0002-7625-2648, Akusjärvi, Göran and Punga, Tanel
(2015)
Complementation of the human adenovirus type 5 VA RNAI defect by the Vaccinia virus E3L protein and serotype-specific VA RNAIs.
Virology, 485,
pp. 25-35.
(doi: 10.1016/j.virol.2015.07.002)
(PMID:26196231)
Pickl, Julia Maria Anna, Kamel, Wael ORCID: https://orcid.org/0000-0002-7625-2648, Ciftci, Sibel, Punga, Tanel and Akusjärvi, Göran
(2015)
Opposite expression of CYP51A1 and its natural antisense transcript AluCYP51A1 in adenovirus type 37 infected retinal pigmented epithelial cells.
FEBS Letters, 589(12),
pp. 1383-1388.
(doi: 10.1016/j.febslet.2015.04.018)
(PMID:25907535)
Kamel, Wael ORCID: https://orcid.org/0000-0002-7625-2648, Segerman, Bo, Punga, Tanel and Akusjarvi, Goran
(2014)
Small RNA sequence analysis of adenovirus VA RNA-derived miRNAs reveals an unexpected serotype-specific difference in structure and abundance.
PloS ONE, 9(8),
e105746.
(doi: 10.1371/journal.pone.0105746)
(PMID:25144466)
(PMCID:PMC4140831)
Kamel, Wael ORCID: https://orcid.org/0000-0002-7625-2648, Segerman, Bo, Öberg, Daniel, Punga, Tanel and Akusjärvi, Göran
(2013)
The adenovirus VA RNA-derived miRNAs are not essential for lytic virus growth in tissue culture cells.
Nucleic Acids Research, 41(9),
pp. 4802-4812.
(doi: 10.1093/nar/gkt172)
(PMID:23525465)
(PMCID:PMC3643585)
Punga, Tanel, Kamel, Wael ORCID: https://orcid.org/0000-0002-7625-2648 and Akusjärvi, Göran
(2013)
Old and new functions for the adenovirus virus-associated RNAs.
Future Virology, 8(4),
pp. 343-356.
(doi: 10.2217/fvl.13.19)
(PMID:29610341)
(PMCID:PMC5910864)
Patents
Kamel, Wael Sayed Saleh Elsayed. Kusjarvi, Göran (2019) Stable RNA molecules. .
Younis, Shady. Kamel, Wael. Akusjarvi, Goran. Andersson, Leif. (2018) Methods for identifying new therapeutic agents. .
Research datasets
2025
Wilson, A., Kamel, W. , Davies, K., De Laurent, Z. R., Arif, R., Clarke, A. T. , Bell-Sakyi, L., Lamont, D., Demyanenko, Y., Noerenberg, M., Kohl, A. , Mohammed, S., Castello, A. and Brennan, B. (2025) Uukuniemi virus infection causes a pervasive remodelling of the RNA-binding proteome in tick cells. [Data Collection]
2023
Rainey, S., Geoghegan, V., Lefteri, D. , Ant, T., Martinez, J. , McNamara, C., Kamel, W. , de Laurent, Z., Castello, A. and Sinkins, S. (2023) Differences in proteome perturbations caused by the Wolbachia strain wAu suggest multiple mechanisms of Wolbachia-mediated antiviral activity. [Data Collection]