Dr Shashi Singh
- Affiliate Researcher (School of Infection & Immunity)
email:
Shashi.Singh@glasgow.ac.uk
WCIP, L6/623, Sir Graeme Davies Building, 126 University Place, Glasgow, Glasgow City
Publications
2025
White, S. E. et al. (2025) TGM6 is a helminth secretory product that mimics TGF-β binding to TGFBR2 to antagonize signaling in fibroblasts. Nature Communications, 16(1), 1847. (doi: 10.1038/s41467-025-56954-z) (PMID:39984487) (PMCID:PMC11845725)
Singh, S. P. et al. (2025) The TGF-β mimic TGM4 achieves cell specificity through combinatorial surface co-receptor binding. EMBO Reports, 26(1), pp. 218-244. (doi: 10.1038/s44319-024-00323-2) (PMID:39609640) (PMCID:PMC11723922)
2023
van Dinther, M. et al. (2023) CD44 acts as a co-receptor for cell-specific enhancement of signaling and regulatory T cell induction by TGM1, a parasite TGF-β mimic. Proceedings of the National Academy of Sciences of the United States of America, 120(34), e230237012. (doi: 10.1073/pnas.2302370120) (PMID:37590410) (PMCID:PMC10450677)
Singh, Shashi Prakash ORCID: https://orcid.org/0000-0002-6029-8115
(2023)
Regulation of the Scar/WAVE complex in migrating cells: a summary of our understanding.
Journal of Biosciences, 48,
16.
(doi: 10.1007/s12038-023-00341-7)
(PMID:37204155)
Li, D. et al. (2023) GxcM-Fbp17/RacC-WASP signaling regulates polarized cortex assembly in migrating cells via Arp2/3. Journal of Cell Biology, 222(6), e202208151. (doi: 10.1083/jcb.202208151) (PMID:37010470) (PMCID:PMC10072221)
2022
Singh, Shashi Prakash ORCID: https://orcid.org/0000-0002-6029-8115, Paschke, Peggy, Tweedy, Luke and Insall, Robert H.
ORCID: https://orcid.org/0000-0003-4898-040X
(2022)
AKT and SGK kinases regulate cell migration by altering Scar/WAVE complex activation and Arp2/3 complex recruitment.
Frontiers in Molecular Biosciences, 9,
965921.
(doi: 10.3389/fmolb.2022.965921)
(PMID:36106016)
(PMCID:PMC9466652)
Singh, Shashi Prakash ORCID: https://orcid.org/0000-0002-6029-8115 and Insall, Robert H.
ORCID: https://orcid.org/0000-0003-4898-040X
(2022)
Under-agarose chemotaxis and migration assays for dictyostelium.
In: Chang, Chenbei and Wang, Jianbo (eds.)
Cell Polarity Signaling: Methods and Protocols.
Series: Methods in Molecular Biology, 2438.
Humana Press: New York, pp. 467-482.
ISBN 9781071620342
(doi: 10.1007/978-1-0716-2035-9_27)
2021
Singh, Shashi Prakash ORCID: https://orcid.org/0000-0002-6029-8115, Thomason, Peter A. and Insall, Robert H.
ORCID: https://orcid.org/0000-0003-4898-040X
(2021)
Extracellular signalling modulates Scar/WAVE complex activity through Abi phosphorylation.
Cells, 10(12),
3485.
(doi: 10.3390/cells10123485)
(PMID:34943993)
(PMCID:PMC8700165)
Yang, Yihong, Li, Dong, Chao, Xiaoting, Singh, Shashi P. ORCID: https://orcid.org/0000-0002-6029-8115, Thomason, Peter, Yan, Yonghong, Dong, Mengqiu, Li, Lei, Insall, Robert H.
ORCID: https://orcid.org/0000-0003-4898-040X and Cai, Huaqing
(2021)
Leep1 interacts with PIP3 and the Scar/WAVE complex to regulate cell migration and macropinocytosis.
Journal of Cell Biology, 220(7),
e202010096.
(doi: 10.1083/jcb.202010096)
(PMID:33978708)
(PMCID:PMC8127007)
Dhakshinamoorthy, Ranjani and Singh, Shashi P. ORCID: https://orcid.org/0000-0002-6029-8115
(2021)
Evolution of reproductive division of labor - lessons learned from the social amoeba Dictyostelium discoideum during its multicellular development.
Frontiers in Cell and Developmental Biology, 9,
599525.
(doi: 10.3389/fcell.2021.599525)
(PMID:33748102)
(PMCID:PMC7969725)
Singh, Shashi Prakash ORCID: https://orcid.org/0000-0002-6029-8115 and Insall, Robert H.
ORCID: https://orcid.org/0000-0003-4898-040X
(2021)
Adhesion stimulates Scar/WAVE phosphorylation in mammalian cells.
Communicative and Integrative Biology, 14(1),
pp. 1-4.
(doi: 10.1080/19420889.2020.1855854)
(PMID:33447346)
(PMCID:PMC7781634)
2020
Singh, Shashi Prakash ORCID: https://orcid.org/0000-0002-6029-8115, Thomason, Peter A., Lilla, Sergio, Schaks, Matthias, Tang, Qing, Goode, Bruce L., Machesky, Laura M.
ORCID: https://orcid.org/0000-0002-7592-9856, Rottner, Klemens and Insall, Robert H.
ORCID: https://orcid.org/0000-0003-4898-040X
(2020)
Cell–substrate adhesion drives Scar/WAVE activation and phosphorylation by a Ste20-family kinase, which controls pseudopod lifetime.
PLoS Biology, 18(8),
e3000774.
(doi: 10.1371/journal.pbio.3000774)
(PMID:32745097)
(PMCID:PMC7425996)
2018
Schaks, Matthias, Singh, Shashi P. ORCID: https://orcid.org/0000-0002-6029-8115, Kage, Frieda, Thomason, Peter, Klünemann, Thomas, Steffen, Anika, Blankenfeldt, Wulf, Stradal, Theresia E., Insall, Robert H.
ORCID: https://orcid.org/0000-0003-4898-040X and Rottner, Klemens
(2018)
Distinct interaction sites of Rac GTPase with WAVE regulatory complex have non-redundant functions in vivo.
Current Biology, 28(22),
3674-3684.e6.
(doi: 10.1016/j.cub.2018.10.002)
(PMID:30393033)
(PMCID:PMC6264382)
2014
Singh, Shashi Prakash ORCID: https://orcid.org/0000-0002-6029-8115, Dhakshinamoorthy, Ranjani, Jaiswal, Pundrik, Schmidt, Stefanie, Thewes, Sascha and Baskar, Ramamurthy
(2014)
The thyroxine inactivating gene, type III deiodinase, suppresses multiple signaling centers in Dictyostelium discoideum.
Developmental Biology, 396(2),
pp. 256-268.
(doi: 10.1016/j.ydbio.2014.10.012)
(PMID:25446527)
2012
Jaiswal, Pundrik, Singh, Shashi Prakash ORCID: https://orcid.org/0000-0002-6029-8115, Aiyar, Prasad, Akkali, Rakhil and Baskar, Ramamurthy
(2012)
Regulation of multiple tip formation by caffeine in cellular slime molds.
BMC Developmental Biology, 12,
26.
(doi: 10.1186/1471-213x-12-26)
(PMID:22928977)
(PMCID:PMC3488011)
Articles
White, S. E. et al. (2025) TGM6 is a helminth secretory product that mimics TGF-β binding to TGFBR2 to antagonize signaling in fibroblasts. Nature Communications, 16(1), 1847. (doi: 10.1038/s41467-025-56954-z) (PMID:39984487) (PMCID:PMC11845725)
Singh, S. P. et al. (2025) The TGF-β mimic TGM4 achieves cell specificity through combinatorial surface co-receptor binding. EMBO Reports, 26(1), pp. 218-244. (doi: 10.1038/s44319-024-00323-2) (PMID:39609640) (PMCID:PMC11723922)
van Dinther, M. et al. (2023) CD44 acts as a co-receptor for cell-specific enhancement of signaling and regulatory T cell induction by TGM1, a parasite TGF-β mimic. Proceedings of the National Academy of Sciences of the United States of America, 120(34), e230237012. (doi: 10.1073/pnas.2302370120) (PMID:37590410) (PMCID:PMC10450677)
Singh, Shashi Prakash ORCID: https://orcid.org/0000-0002-6029-8115
(2023)
Regulation of the Scar/WAVE complex in migrating cells: a summary of our understanding.
Journal of Biosciences, 48,
16.
(doi: 10.1007/s12038-023-00341-7)
(PMID:37204155)
Li, D. et al. (2023) GxcM-Fbp17/RacC-WASP signaling regulates polarized cortex assembly in migrating cells via Arp2/3. Journal of Cell Biology, 222(6), e202208151. (doi: 10.1083/jcb.202208151) (PMID:37010470) (PMCID:PMC10072221)
Singh, Shashi Prakash ORCID: https://orcid.org/0000-0002-6029-8115, Paschke, Peggy, Tweedy, Luke and Insall, Robert H.
ORCID: https://orcid.org/0000-0003-4898-040X
(2022)
AKT and SGK kinases regulate cell migration by altering Scar/WAVE complex activation and Arp2/3 complex recruitment.
Frontiers in Molecular Biosciences, 9,
965921.
(doi: 10.3389/fmolb.2022.965921)
(PMID:36106016)
(PMCID:PMC9466652)
Singh, Shashi Prakash ORCID: https://orcid.org/0000-0002-6029-8115, Thomason, Peter A. and Insall, Robert H.
ORCID: https://orcid.org/0000-0003-4898-040X
(2021)
Extracellular signalling modulates Scar/WAVE complex activity through Abi phosphorylation.
Cells, 10(12),
3485.
(doi: 10.3390/cells10123485)
(PMID:34943993)
(PMCID:PMC8700165)
Yang, Yihong, Li, Dong, Chao, Xiaoting, Singh, Shashi P. ORCID: https://orcid.org/0000-0002-6029-8115, Thomason, Peter, Yan, Yonghong, Dong, Mengqiu, Li, Lei, Insall, Robert H.
ORCID: https://orcid.org/0000-0003-4898-040X and Cai, Huaqing
(2021)
Leep1 interacts with PIP3 and the Scar/WAVE complex to regulate cell migration and macropinocytosis.
Journal of Cell Biology, 220(7),
e202010096.
(doi: 10.1083/jcb.202010096)
(PMID:33978708)
(PMCID:PMC8127007)
Dhakshinamoorthy, Ranjani and Singh, Shashi P. ORCID: https://orcid.org/0000-0002-6029-8115
(2021)
Evolution of reproductive division of labor - lessons learned from the social amoeba Dictyostelium discoideum during its multicellular development.
Frontiers in Cell and Developmental Biology, 9,
599525.
(doi: 10.3389/fcell.2021.599525)
(PMID:33748102)
(PMCID:PMC7969725)
Singh, Shashi Prakash ORCID: https://orcid.org/0000-0002-6029-8115 and Insall, Robert H.
ORCID: https://orcid.org/0000-0003-4898-040X
(2021)
Adhesion stimulates Scar/WAVE phosphorylation in mammalian cells.
Communicative and Integrative Biology, 14(1),
pp. 1-4.
(doi: 10.1080/19420889.2020.1855854)
(PMID:33447346)
(PMCID:PMC7781634)
Singh, Shashi Prakash ORCID: https://orcid.org/0000-0002-6029-8115, Thomason, Peter A., Lilla, Sergio, Schaks, Matthias, Tang, Qing, Goode, Bruce L., Machesky, Laura M.
ORCID: https://orcid.org/0000-0002-7592-9856, Rottner, Klemens and Insall, Robert H.
ORCID: https://orcid.org/0000-0003-4898-040X
(2020)
Cell–substrate adhesion drives Scar/WAVE activation and phosphorylation by a Ste20-family kinase, which controls pseudopod lifetime.
PLoS Biology, 18(8),
e3000774.
(doi: 10.1371/journal.pbio.3000774)
(PMID:32745097)
(PMCID:PMC7425996)
Schaks, Matthias, Singh, Shashi P. ORCID: https://orcid.org/0000-0002-6029-8115, Kage, Frieda, Thomason, Peter, Klünemann, Thomas, Steffen, Anika, Blankenfeldt, Wulf, Stradal, Theresia E., Insall, Robert H.
ORCID: https://orcid.org/0000-0003-4898-040X and Rottner, Klemens
(2018)
Distinct interaction sites of Rac GTPase with WAVE regulatory complex have non-redundant functions in vivo.
Current Biology, 28(22),
3674-3684.e6.
(doi: 10.1016/j.cub.2018.10.002)
(PMID:30393033)
(PMCID:PMC6264382)
Singh, Shashi Prakash ORCID: https://orcid.org/0000-0002-6029-8115, Dhakshinamoorthy, Ranjani, Jaiswal, Pundrik, Schmidt, Stefanie, Thewes, Sascha and Baskar, Ramamurthy
(2014)
The thyroxine inactivating gene, type III deiodinase, suppresses multiple signaling centers in Dictyostelium discoideum.
Developmental Biology, 396(2),
pp. 256-268.
(doi: 10.1016/j.ydbio.2014.10.012)
(PMID:25446527)
Jaiswal, Pundrik, Singh, Shashi Prakash ORCID: https://orcid.org/0000-0002-6029-8115, Aiyar, Prasad, Akkali, Rakhil and Baskar, Ramamurthy
(2012)
Regulation of multiple tip formation by caffeine in cellular slime molds.
BMC Developmental Biology, 12,
26.
(doi: 10.1186/1471-213x-12-26)
(PMID:22928977)
(PMCID:PMC3488011)
Book Sections
Singh, Shashi Prakash ORCID: https://orcid.org/0000-0002-6029-8115 and Insall, Robert H.
ORCID: https://orcid.org/0000-0003-4898-040X
(2022)
Under-agarose chemotaxis and migration assays for dictyostelium.
In: Chang, Chenbei and Wang, Jianbo (eds.)
Cell Polarity Signaling: Methods and Protocols.
Series: Methods in Molecular Biology, 2438.
Humana Press: New York, pp. 467-482.
ISBN 9781071620342
(doi: 10.1007/978-1-0716-2035-9_27)