Dr Rebecca McHugh

  • BBSRC Fellow (Bacteriology)

Publications

List by: Type | Date

Jump to: 2025 | 2024 | 2023 | 2022 | 2020 | 2019
Number of items: 14.

2025

McHugh, Rebecca E. ORCID logoORCID: https://orcid.org/0000-0003-4664-6125, Rooney, Liam M. ORCID logoORCID: https://orcid.org/0000-0002-2237-501X, Mark, David R. ORCID logoORCID: https://orcid.org/0000-0002-1688-5224, Wale, Kabo R., Clapperton, Megan, McConnell, Gail, Hoskisson, Paul A., Douce, Gillian R. ORCID logoORCID: https://orcid.org/0000-0002-6654-7346 and Roe, Andrew J. ORCID logoORCID: https://orcid.org/0000-0003-3698-6134 (2025) Evaluating the protective effects of Aurodox in a murine model of Shiga toxin-producing Escherichia coli. npj Antimicrobials and Resistance, 3(1), 23. (doi: 10.1038/s44259-025-00094-3) (PMID:40169888) (PMCID:PMC11962119)

2024

Christopher, Jay, Craig, Rebecca, McHugh, Rebecca E. ORCID logoORCID: https://orcid.org/0000-0003-4664-6125, Roe, Andrew J. ORCID logoORCID: https://orcid.org/0000-0003-3698-6134, Bauer, Ralf, Patton, Brian, McConnell, Gail and Rooney, Liam M. (2024) A fully 3D-printed optical microscope for low-cost histological imaging. bioRxiv, (doi: 10.1101/2024.12.16.628684)

Mark, David R. ORCID logoORCID: https://orcid.org/0000-0002-1688-5224, O'Boyle, Nicky, Wale, Kabo Ronald, Tucker, Samantha K., McHugh, Rebecca E. ORCID logoORCID: https://orcid.org/0000-0003-4664-6125 and Roe, Andrew J. ORCID logoORCID: https://orcid.org/0000-0003-3698-6134 (2024) Aurodox inhibits type III secretion in multiple Gram-negative pathogens. Open Biology, 14(11), 240240. (doi: 10.1098/rsob.240240) (PMID:39591989) (PMCID:PMC11597412)

Wale, Kabo R., O'Boyle, Nicky, McHugh, Rebecca ORCID logoORCID: https://orcid.org/0000-0003-4664-6125, Serrano, Ester ORCID logoORCID: https://orcid.org/0000-0001-5075-2954, Mark, David ORCID logoORCID: https://orcid.org/0000-0002-1688-5224, Douce, Gillian R. ORCID logoORCID: https://orcid.org/0000-0002-6654-7346, Connolly, James P.R. and Roe, Andrew J. ORCID logoORCID: https://orcid.org/0000-0003-3698-6134 (2024) A master regulator of central carbon metabolism directly activates virulence gene expression in attaching and effacing pathogens. PLoS Pathogens, 20(10), e101245. (doi: 10.1371/journal.ppat.1012451) (PMID:39405360) (PMCID:PMC11508082)

Mark, David ORCID logoORCID: https://orcid.org/0000-0002-1688-5224, Trolan, Mia, Douce, Gillian, Roe, Andrew J. ORCID logoORCID: https://orcid.org/0000-0003-3698-6134 and McHugh, Rebecca E. ORCID logoORCID: https://orcid.org/0000-0003-4664-6125 (2024) The enemy within: how pathogen-free are your commercial specific pathogen-free mice? bioRxiv, (doi: 10.1101/2024.07.05.602177)

Tucker, Samantha K., McHugh, Rebecca E. ORCID logoORCID: https://orcid.org/0000-0003-4664-6125 and Roe, Andrew ORCID logoORCID: https://orcid.org/0000-0003-3698-6134 (2024) One problem, multiple potential targets: where are we now in the development of small molecule inhibitors against Shiga toxin? Cellular Signalling, 121, 111253. (doi: 10.1016/j.cellsig.2024.111253) (PMID:38852937)

Mark, David ORCID logoORCID: https://orcid.org/0000-0002-1688-5224, O’Boyle, Nicky, Wale, Kabo R., Tucker, Samantha K., McHugh, Rebecca E. ORCID logoORCID: https://orcid.org/0000-0003-4664-6125 and Roe, Andrew J. ORCID logoORCID: https://orcid.org/0000-0003-3698-6134 (2024) Aurodox, a polyketide from Streptomyces goldiniensis, inhibits transcription of the type III secretion system of multiple Gram-negative pathogens. bioRxiv, (doi: 10.1101/2024.04.19.589875)

2023

McHugh, Rebecca E. ORCID logoORCID: https://orcid.org/0000-0003-4664-6125, Giard, Josephine, Braes, Robyn E., McKean, Iain, Roe, Andrew J. ORCID logoORCID: https://orcid.org/0000-0003-3698-6134 and Hoskisson, Paul A. (2023) Optimisation of aurodox production by Streptomyces goldiniensis. Access Microbiology, (doi: 10.1099/acmi.0.000572.v1)

2022

McHugh, Rebecca E. ORCID logoORCID: https://orcid.org/0000-0003-4664-6125, Munnoch, John T., Braes, Robyn E., McKean, Iain J. W., Giard, Josephine, Taladriz-Sender, Andrea, Peschke, Frederik, Burley, Glenn A., Roe, Andrew J. ORCID logoORCID: https://orcid.org/0000-0003-3698-6134 and Hoskisson, Paul A. (2022) Biosynthesis of aurodox, a type III secretion system inhibitor from streptomyces goldiniensis. Applied and Environmental Microbiology, 88(15), e0069222. (doi: 10.1128/aem.00692-22) (PMID:35867559) (PMCID:PMC9361827)

McHugh, Rebecca E. ORCID logoORCID: https://orcid.org/0000-0003-4664-6125, Munnoch, John T., Roe, Andrew J. ORCID logoORCID: https://orcid.org/0000-0003-3698-6134 and Hoskisson, Paul A. (2022) Genome sequence of the aurodox-producing bacterium Streptomyces goldiniensis ATCC 21386. Access Microbiology, 4(5), 000358. (doi: 10.1099/acmi.0.000358) (PMID:36003359) (PMCID:PMC9394534)

Hibbert, Tegan, Krpetic, Zeljka, Latimer, Joe, Leighton, Hollie, McHugh, Rebecca ORCID logoORCID: https://orcid.org/0000-0003-4664-6125, Pottenger, Sian, Wragg, Charlotte and James, Chloë (2022) Antimicrobials: An update on new strategies to diversify treatment for bacterial infections. In: Poole, Robert K. and Kelly, David J. (eds.) Advances in Microbial Physiology. Academic Press. ISBN 9780443295409 (doi: 10.1016/bs.ampbs.2023.12.002)

2020

Pollock, J., Low, A.S., McHugh, R.E. ORCID logoORCID: https://orcid.org/0000-0003-4664-6125, Muwonge, A., Stevens, M.P., Corbishley, A. and Gally, D.L. (2020) Alternatives to antibiotics in a One Health context and the role genomics can play in reducing antimicrobial use. Clinical Microbiology and Infection, 26(12), pp. 1617-1621. (doi: 10.1016/j.cmi.2020.02.028) (PMID:32220638)

2019

McHugh, Rebecca E. ORCID logoORCID: https://orcid.org/0000-0003-4664-6125, O'Boyle, Nicky, Connolly, James P.R., Hoskisson, Paul A. and Roe, Andrew J. ORCID logoORCID: https://orcid.org/0000-0003-3698-6134 (2019) Characterisation of the mode of action of Aurodox, a Type III secretion system inhibitor from Streptomyces goldiniensis. Infection and Immunity, 87(2), e00595-18. (doi: 10.1128/IAI.00595-18) (PMID:30455200) (PMCID:PMC6346137)

McHugh, Rebecca E. ORCID logoORCID: https://orcid.org/0000-0003-4664-6125, O'Boyle, Nicky, Connolly, James P.R., Hoskisson, Paul A. and Roe, Andrew J. (2019) Characterization of the mode of action of Aurodox, a type III secretion system inhibitor from streptomyces goldiniensis. Infection and Immunity, 87(2), e00595-18. (doi: 10.1128/IAI.00595-18) (PMID:30455200) (PMCID:PMC6346137)

This list was generated on Sun Jun 15 13:30:02 2025 BST.
Jump to: Articles | Book Sections
Number of items: 14.

Articles

McHugh, Rebecca E. ORCID logoORCID: https://orcid.org/0000-0003-4664-6125, Rooney, Liam M. ORCID logoORCID: https://orcid.org/0000-0002-2237-501X, Mark, David R. ORCID logoORCID: https://orcid.org/0000-0002-1688-5224, Wale, Kabo R., Clapperton, Megan, McConnell, Gail, Hoskisson, Paul A., Douce, Gillian R. ORCID logoORCID: https://orcid.org/0000-0002-6654-7346 and Roe, Andrew J. ORCID logoORCID: https://orcid.org/0000-0003-3698-6134 (2025) Evaluating the protective effects of Aurodox in a murine model of Shiga toxin-producing Escherichia coli. npj Antimicrobials and Resistance, 3(1), 23. (doi: 10.1038/s44259-025-00094-3) (PMID:40169888) (PMCID:PMC11962119)

Christopher, Jay, Craig, Rebecca, McHugh, Rebecca E. ORCID logoORCID: https://orcid.org/0000-0003-4664-6125, Roe, Andrew J. ORCID logoORCID: https://orcid.org/0000-0003-3698-6134, Bauer, Ralf, Patton, Brian, McConnell, Gail and Rooney, Liam M. (2024) A fully 3D-printed optical microscope for low-cost histological imaging. bioRxiv, (doi: 10.1101/2024.12.16.628684)

Mark, David R. ORCID logoORCID: https://orcid.org/0000-0002-1688-5224, O'Boyle, Nicky, Wale, Kabo Ronald, Tucker, Samantha K., McHugh, Rebecca E. ORCID logoORCID: https://orcid.org/0000-0003-4664-6125 and Roe, Andrew J. ORCID logoORCID: https://orcid.org/0000-0003-3698-6134 (2024) Aurodox inhibits type III secretion in multiple Gram-negative pathogens. Open Biology, 14(11), 240240. (doi: 10.1098/rsob.240240) (PMID:39591989) (PMCID:PMC11597412)

Wale, Kabo R., O'Boyle, Nicky, McHugh, Rebecca ORCID logoORCID: https://orcid.org/0000-0003-4664-6125, Serrano, Ester ORCID logoORCID: https://orcid.org/0000-0001-5075-2954, Mark, David ORCID logoORCID: https://orcid.org/0000-0002-1688-5224, Douce, Gillian R. ORCID logoORCID: https://orcid.org/0000-0002-6654-7346, Connolly, James P.R. and Roe, Andrew J. ORCID logoORCID: https://orcid.org/0000-0003-3698-6134 (2024) A master regulator of central carbon metabolism directly activates virulence gene expression in attaching and effacing pathogens. PLoS Pathogens, 20(10), e101245. (doi: 10.1371/journal.ppat.1012451) (PMID:39405360) (PMCID:PMC11508082)

Mark, David ORCID logoORCID: https://orcid.org/0000-0002-1688-5224, Trolan, Mia, Douce, Gillian, Roe, Andrew J. ORCID logoORCID: https://orcid.org/0000-0003-3698-6134 and McHugh, Rebecca E. ORCID logoORCID: https://orcid.org/0000-0003-4664-6125 (2024) The enemy within: how pathogen-free are your commercial specific pathogen-free mice? bioRxiv, (doi: 10.1101/2024.07.05.602177)

Tucker, Samantha K., McHugh, Rebecca E. ORCID logoORCID: https://orcid.org/0000-0003-4664-6125 and Roe, Andrew ORCID logoORCID: https://orcid.org/0000-0003-3698-6134 (2024) One problem, multiple potential targets: where are we now in the development of small molecule inhibitors against Shiga toxin? Cellular Signalling, 121, 111253. (doi: 10.1016/j.cellsig.2024.111253) (PMID:38852937)

Mark, David ORCID logoORCID: https://orcid.org/0000-0002-1688-5224, O’Boyle, Nicky, Wale, Kabo R., Tucker, Samantha K., McHugh, Rebecca E. ORCID logoORCID: https://orcid.org/0000-0003-4664-6125 and Roe, Andrew J. ORCID logoORCID: https://orcid.org/0000-0003-3698-6134 (2024) Aurodox, a polyketide from Streptomyces goldiniensis, inhibits transcription of the type III secretion system of multiple Gram-negative pathogens. bioRxiv, (doi: 10.1101/2024.04.19.589875)

McHugh, Rebecca E. ORCID logoORCID: https://orcid.org/0000-0003-4664-6125, Giard, Josephine, Braes, Robyn E., McKean, Iain, Roe, Andrew J. ORCID logoORCID: https://orcid.org/0000-0003-3698-6134 and Hoskisson, Paul A. (2023) Optimisation of aurodox production by Streptomyces goldiniensis. Access Microbiology, (doi: 10.1099/acmi.0.000572.v1)

McHugh, Rebecca E. ORCID logoORCID: https://orcid.org/0000-0003-4664-6125, Munnoch, John T., Braes, Robyn E., McKean, Iain J. W., Giard, Josephine, Taladriz-Sender, Andrea, Peschke, Frederik, Burley, Glenn A., Roe, Andrew J. ORCID logoORCID: https://orcid.org/0000-0003-3698-6134 and Hoskisson, Paul A. (2022) Biosynthesis of aurodox, a type III secretion system inhibitor from streptomyces goldiniensis. Applied and Environmental Microbiology, 88(15), e0069222. (doi: 10.1128/aem.00692-22) (PMID:35867559) (PMCID:PMC9361827)

McHugh, Rebecca E. ORCID logoORCID: https://orcid.org/0000-0003-4664-6125, Munnoch, John T., Roe, Andrew J. ORCID logoORCID: https://orcid.org/0000-0003-3698-6134 and Hoskisson, Paul A. (2022) Genome sequence of the aurodox-producing bacterium Streptomyces goldiniensis ATCC 21386. Access Microbiology, 4(5), 000358. (doi: 10.1099/acmi.0.000358) (PMID:36003359) (PMCID:PMC9394534)

Pollock, J., Low, A.S., McHugh, R.E. ORCID logoORCID: https://orcid.org/0000-0003-4664-6125, Muwonge, A., Stevens, M.P., Corbishley, A. and Gally, D.L. (2020) Alternatives to antibiotics in a One Health context and the role genomics can play in reducing antimicrobial use. Clinical Microbiology and Infection, 26(12), pp. 1617-1621. (doi: 10.1016/j.cmi.2020.02.028) (PMID:32220638)

McHugh, Rebecca E. ORCID logoORCID: https://orcid.org/0000-0003-4664-6125, O'Boyle, Nicky, Connolly, James P.R., Hoskisson, Paul A. and Roe, Andrew J. ORCID logoORCID: https://orcid.org/0000-0003-3698-6134 (2019) Characterisation of the mode of action of Aurodox, a Type III secretion system inhibitor from Streptomyces goldiniensis. Infection and Immunity, 87(2), e00595-18. (doi: 10.1128/IAI.00595-18) (PMID:30455200) (PMCID:PMC6346137)

McHugh, Rebecca E. ORCID logoORCID: https://orcid.org/0000-0003-4664-6125, O'Boyle, Nicky, Connolly, James P.R., Hoskisson, Paul A. and Roe, Andrew J. (2019) Characterization of the mode of action of Aurodox, a type III secretion system inhibitor from streptomyces goldiniensis. Infection and Immunity, 87(2), e00595-18. (doi: 10.1128/IAI.00595-18) (PMID:30455200) (PMCID:PMC6346137)

Book Sections

Hibbert, Tegan, Krpetic, Zeljka, Latimer, Joe, Leighton, Hollie, McHugh, Rebecca ORCID logoORCID: https://orcid.org/0000-0003-4664-6125, Pottenger, Sian, Wragg, Charlotte and James, Chloë (2022) Antimicrobials: An update on new strategies to diversify treatment for bacterial infections. In: Poole, Robert K. and Kelly, David J. (eds.) Advances in Microbial Physiology. Academic Press. ISBN 9780443295409 (doi: 10.1016/bs.ampbs.2023.12.002)

This list was generated on Sun Jun 15 13:30:02 2025 BST.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Targeting secretion systems: novel compounds that block bacterial infections
    Biotechnology and Biological Sciences Research Council
    2025 - 2028
     
  • Genome mining of the bovine faecal bacterium for novel bioactive compounds
    The Carnegie Trust for the Universities of Scotland
    2023 - 2024
     

Professional activities & recognition

Prizes, awards & distinctions

  • 2023: Research Incentive Grant (Carnegie Trust)
  • 2022: Infection Science Award (Microbiology Society)
  • 2022: Mike Goodfellow Prize (ISBA)
  • 2022: Outstanding Science Prize (Microbiology Society)

Professional & learned societies

  • 2020 - 22: Early Career Executive Forum, Microbiology Society
  • 2022 - 2024: Building Communities Committee, Microbiology Society

Selected international presentations

  • 2023: World Pharmacology Congress (Glasgow)
  • 2022: ISBA (Toronto)