Dr James Shepherd
- Honorary Clinical Senior Lecturer (School of Infection & Immunity)
email:
James.Shepherd.2@glasgow.ac.uk
Level 4 New Lister Building, Glasgow Royal Infirmary, 10 - 16 Alexandra Parade, Glasgow, G31 2ER
Publications
2025
Kugler, M. et al. (2025) Occupational Exposure of Healthcare Workers and Rural Communities to Viral Haemorrhagic Fever Viruses in Uganda. Project Report. University of Glasgow. (doi: 10.36399/gla.pubs.349489).
Ashraf, S. et al. (2025) Uncovering the viral aetiology of undiagnosed acute febrile illness in Uganda using metagenomic sequencing. Nature Communications, 16, 2844. (doi: 10.1038/s41467-025-57696-8) (PMID:40122843) (PMCID:PMC11930947)
2024
Shepherd, J. G. et al. (2024) Widespread human exposure to ledanteviruses in Uganda: A population study. PLoS Neglected Tropical Diseases, 18(7), e0012297. (doi: 10.1371/journal.pntd.0012297) (PMID:38976760) (PMCID:PMC11257405)
2023
Pascall, D. J. et al. (2023) Directions of change in intrinsic case severity across successive SARS-CoV-2 variant waves have been inconsistent. Journal of Infection, 87(2), pp. 128-135. (doi: 10.1016/j.jinf.2023.05.019) (PMID:37270070) (PMCID:PMC10234362)
Shepherd, James G. ORCID: https://orcid.org/0000-0003-3915-048X, Davis, Chris
ORCID: https://orcid.org/0000-0002-7317-3266, Streicker, Daniel G.
ORCID: https://orcid.org/0000-0001-7475-2705 and Thomson, Emma C.
ORCID: https://orcid.org/0000-0003-1482-0889
(2023)
Emerging rhabdoviruses and human infection.
Biology, 12(6),
878.
(doi: 10.3390/biology12060878)
(PMID:37372162)
(PMCID:PMC10294888)
Pascall, D. J. et al. (2023) The SARS-CoV-2 Alpha variant was associated with increased clinical severity of COVID-19 in Scotland: a genomics-based retrospective cohort analysis. PLoS ONE, 18(4), e0284187. (doi: 10.1371/journal.pone.0284187) (PMID:37053201) (PMCID:PMC10101505)
2022
Atim, S. A. et al. (2022) Risk factors for Crimean-Congo Haemorrhagic Fever (CCHF) virus exposure in farming communities in Uganda. Journal of Infection, 85(6), pp. 693-701. (doi: 10.1016/j.jinf.2022.09.007) (PMID:36108783) (PMCID:PMC9731351)
Aggarwal, D. et al. (2022) Genomic assessment of quarantine measures to prevent SARS-CoV-2 importation and transmission. Nature Communications, 13, 1012. (doi: 10.1038/s41467-022-28371-z) (PMID:35197443) (PMCID:PMC8866425)
Aggarwal, D. et al. (2022) Genomic epidemiology of SARS-CoV-2 in a UK university identifies dynamics of transmission. Nature Communications, 13, 751. (doi: 10.1038/s41467-021-27942-w) (PMID:35136068) (PMCID:PMC8826310)
Twohig, K. A. et al. (2022) Hospital admission and emergency care attendance risk for SARS-CoV-2 delta (B.1.617.2) compared with alpha (B.1.1.7) variants of concern: a cohort study. Lancet Infectious Diseases, 22(1), pp. 35-42. (doi: 10.1016/S1473-3099(21)00475-8) (PMID:34461056) (PMCID:PMC8397301)
2021
Vöhringer, H. S. et al. (2021) Genomic reconstruction of the SARS-CoV-2 epidemic in England. Nature, 600(7889), pp. 506-511. (doi: 10.1038/s41586-021-04069-y) (PMID:34649268) (PMCID:PMC8674138)
Shepherd, J. G. et al. (2021) Seoul virus associated with pet pats, Scotland, UK, 2019. Emerging Infectious Diseases, 27(10), pp. 2677-2680. (doi: 10.3201/eid2710.211298) (PMID:34545785) (PMCID:PMC8462346)
Thomson, Emma ORCID: https://orcid.org/0000-0003-1482-0889, Shah, Rajiv, Ahovegbe, Lucrece, Niebel, Marc
ORCID: https://orcid.org/0000-0003-2515-6151 and Shepherd, James
ORCID: https://orcid.org/0000-0003-3915-048X
(2021)
Non-epidemic HCV genotypes in low- and middle-income countries and the risk of resistance to current direct-acting antiviral regimens.
Journal of Hepatology, 75(2),
pp. 462-473.
(doi: 10.1016/j.jhep.2021.04.045)
(PMID:33974951)
(PMCID:PMC8310923)
Li, K. K. et al. (2021) Genetic epidemiology of SARS-CoV-2 transmission in renal dialysis units - a high risk community-hospital interface. Journal of Infection, 83(1), pp. 96-103. (doi: 10.1016/j.jinf.2021.04.020) (PMID:33895226) (PMCID:PMC8061788)
Stirrup, O. et al. (2021) Rapid feedback on hospital onset SARS-CoV-2 infections combining epidemiological and sequencing data. eLife, 10, e65828. (doi: 10.7554/elife.65828) (PMID:34184637) (PMCID:PMC8285103)
Graham, M. S. et al. (2021) Changes in symptomatology, reinfection, and transmissibility associated with the SARS-CoV-2 variant B.1.1.7: an ecological study. Lancet Public Health, 6(5), e335-e345. (doi: 10.1016/S2468-2667(21)00055-4)
Volz, E. et al. (2021) Assessing transmissibility of SARS-CoV-2 lineage B.1.1.7 in England. Nature, 593(7858), pp. 266-269. (doi: 10.1038/s41586-021-03470-x) (PMID:33767447)
Lythgoe, K. A. et al. (2021) SARS-CoV-2 within-host diversity and transmission. Science, 372(6539), eabg0821. (doi: 10.1126/science.abg0821) (PMID:33688063) (PMCID:PMC8128293)
Thomson, E. C. et al. (2021) Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity. Cell, 184(5), 1171-1187.e20. (doi: 10.1016/j.cell.2021.01.037) (PMID:33621484) (PMCID:PMC7843029)
Rihn, S. J. et al. (2021) A plasmid DNA-launched SARS-CoV-2 reverse genetics system and coronavirus toolkit for COVID-19 research. PLoS Biology, 19(2), e3001091. (doi: 10.1371/journal.pbio.3001091) (PMID:33630831) (PMCID:PMC7906417)
Volz, E. et al. (2021) Evaluating the effects of SARS-CoV-2 Spike mutation D614G on transmissibility and pathogenicity. Cell, 184(1), 64-75.e11. (doi: 10.1016/j.cell.2020.11.020) (PMID:33275900) (PMCID:PMC7674007)
Da Silva Filipe, A. et al. (2021) Genomic epidemiology reveals multiple introductions of SARS-CoV-2 from mainland Europe into Scotland. Nature Microbiology, 6(1), pp. 112-122. (doi: 10.1038/s41564-020-00838-z) (PMID:33349681)
Parker, M. D. et al. (2021) Subgenomic RNA identification in SARS-CoV-2 genomic sequencing data. Genome Research, 31, pp. 645-658. (doi: 10.1101/gr.268110.120) (PMID:33722935) (PMCID:PMC8015849)
Articles
Ashraf, S. et al. (2025) Uncovering the viral aetiology of undiagnosed acute febrile illness in Uganda using metagenomic sequencing. Nature Communications, 16, 2844. (doi: 10.1038/s41467-025-57696-8) (PMID:40122843) (PMCID:PMC11930947)
Shepherd, J. G. et al. (2024) Widespread human exposure to ledanteviruses in Uganda: A population study. PLoS Neglected Tropical Diseases, 18(7), e0012297. (doi: 10.1371/journal.pntd.0012297) (PMID:38976760) (PMCID:PMC11257405)
Pascall, D. J. et al. (2023) Directions of change in intrinsic case severity across successive SARS-CoV-2 variant waves have been inconsistent. Journal of Infection, 87(2), pp. 128-135. (doi: 10.1016/j.jinf.2023.05.019) (PMID:37270070) (PMCID:PMC10234362)
Shepherd, James G. ORCID: https://orcid.org/0000-0003-3915-048X, Davis, Chris
ORCID: https://orcid.org/0000-0002-7317-3266, Streicker, Daniel G.
ORCID: https://orcid.org/0000-0001-7475-2705 and Thomson, Emma C.
ORCID: https://orcid.org/0000-0003-1482-0889
(2023)
Emerging rhabdoviruses and human infection.
Biology, 12(6),
878.
(doi: 10.3390/biology12060878)
(PMID:37372162)
(PMCID:PMC10294888)
Pascall, D. J. et al. (2023) The SARS-CoV-2 Alpha variant was associated with increased clinical severity of COVID-19 in Scotland: a genomics-based retrospective cohort analysis. PLoS ONE, 18(4), e0284187. (doi: 10.1371/journal.pone.0284187) (PMID:37053201) (PMCID:PMC10101505)
Atim, S. A. et al. (2022) Risk factors for Crimean-Congo Haemorrhagic Fever (CCHF) virus exposure in farming communities in Uganda. Journal of Infection, 85(6), pp. 693-701. (doi: 10.1016/j.jinf.2022.09.007) (PMID:36108783) (PMCID:PMC9731351)
Aggarwal, D. et al. (2022) Genomic assessment of quarantine measures to prevent SARS-CoV-2 importation and transmission. Nature Communications, 13, 1012. (doi: 10.1038/s41467-022-28371-z) (PMID:35197443) (PMCID:PMC8866425)
Aggarwal, D. et al. (2022) Genomic epidemiology of SARS-CoV-2 in a UK university identifies dynamics of transmission. Nature Communications, 13, 751. (doi: 10.1038/s41467-021-27942-w) (PMID:35136068) (PMCID:PMC8826310)
Twohig, K. A. et al. (2022) Hospital admission and emergency care attendance risk for SARS-CoV-2 delta (B.1.617.2) compared with alpha (B.1.1.7) variants of concern: a cohort study. Lancet Infectious Diseases, 22(1), pp. 35-42. (doi: 10.1016/S1473-3099(21)00475-8) (PMID:34461056) (PMCID:PMC8397301)
Vöhringer, H. S. et al. (2021) Genomic reconstruction of the SARS-CoV-2 epidemic in England. Nature, 600(7889), pp. 506-511. (doi: 10.1038/s41586-021-04069-y) (PMID:34649268) (PMCID:PMC8674138)
Shepherd, J. G. et al. (2021) Seoul virus associated with pet pats, Scotland, UK, 2019. Emerging Infectious Diseases, 27(10), pp. 2677-2680. (doi: 10.3201/eid2710.211298) (PMID:34545785) (PMCID:PMC8462346)
Thomson, Emma ORCID: https://orcid.org/0000-0003-1482-0889, Shah, Rajiv, Ahovegbe, Lucrece, Niebel, Marc
ORCID: https://orcid.org/0000-0003-2515-6151 and Shepherd, James
ORCID: https://orcid.org/0000-0003-3915-048X
(2021)
Non-epidemic HCV genotypes in low- and middle-income countries and the risk of resistance to current direct-acting antiviral regimens.
Journal of Hepatology, 75(2),
pp. 462-473.
(doi: 10.1016/j.jhep.2021.04.045)
(PMID:33974951)
(PMCID:PMC8310923)
Li, K. K. et al. (2021) Genetic epidemiology of SARS-CoV-2 transmission in renal dialysis units - a high risk community-hospital interface. Journal of Infection, 83(1), pp. 96-103. (doi: 10.1016/j.jinf.2021.04.020) (PMID:33895226) (PMCID:PMC8061788)
Stirrup, O. et al. (2021) Rapid feedback on hospital onset SARS-CoV-2 infections combining epidemiological and sequencing data. eLife, 10, e65828. (doi: 10.7554/elife.65828) (PMID:34184637) (PMCID:PMC8285103)
Graham, M. S. et al. (2021) Changes in symptomatology, reinfection, and transmissibility associated with the SARS-CoV-2 variant B.1.1.7: an ecological study. Lancet Public Health, 6(5), e335-e345. (doi: 10.1016/S2468-2667(21)00055-4)
Volz, E. et al. (2021) Assessing transmissibility of SARS-CoV-2 lineage B.1.1.7 in England. Nature, 593(7858), pp. 266-269. (doi: 10.1038/s41586-021-03470-x) (PMID:33767447)
Lythgoe, K. A. et al. (2021) SARS-CoV-2 within-host diversity and transmission. Science, 372(6539), eabg0821. (doi: 10.1126/science.abg0821) (PMID:33688063) (PMCID:PMC8128293)
Thomson, E. C. et al. (2021) Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity. Cell, 184(5), 1171-1187.e20. (doi: 10.1016/j.cell.2021.01.037) (PMID:33621484) (PMCID:PMC7843029)
Rihn, S. J. et al. (2021) A plasmid DNA-launched SARS-CoV-2 reverse genetics system and coronavirus toolkit for COVID-19 research. PLoS Biology, 19(2), e3001091. (doi: 10.1371/journal.pbio.3001091) (PMID:33630831) (PMCID:PMC7906417)
Volz, E. et al. (2021) Evaluating the effects of SARS-CoV-2 Spike mutation D614G on transmissibility and pathogenicity. Cell, 184(1), 64-75.e11. (doi: 10.1016/j.cell.2020.11.020) (PMID:33275900) (PMCID:PMC7674007)
Da Silva Filipe, A. et al. (2021) Genomic epidemiology reveals multiple introductions of SARS-CoV-2 from mainland Europe into Scotland. Nature Microbiology, 6(1), pp. 112-122. (doi: 10.1038/s41564-020-00838-z) (PMID:33349681)
Parker, M. D. et al. (2021) Subgenomic RNA identification in SARS-CoV-2 genomic sequencing data. Genome Research, 31, pp. 645-658. (doi: 10.1101/gr.268110.120) (PMID:33722935) (PMCID:PMC8015849)
Research Reports or Papers
Kugler, M. et al. (2025) Occupational Exposure of Healthcare Workers and Rural Communities to Viral Haemorrhagic Fever Viruses in Uganda. Project Report. University of Glasgow. (doi: 10.36399/gla.pubs.349489).
Grants
Grants and Awards listed are those received whilst working with the University of Glasgow.
- Investigating the potency and breadth of the human and bovine antibody response against the Crimean-Congo Haemorrhagic Fever virus in Uganda
British Infection Association
2024 - 2025