Dr Gavin Meehan

  • Affiliate Researcher (School of Infection & Immunity)

email: Gavin.Meehan@glasgow.ac.uk

MRC-University of Glasgow Centre for Virus Research, Sir Michael Stoker Building, Garscube Campus, 464 Bearsden Road, G61 1QH

Import to contacts

ORCID iDhttps://orcid.org/0000-0001-9855-6565

Biography

I received a MSci (hons) degree in pharmacology from the University of Glasgow in 2011. As part of this degree I undertook research in the life sciences industry, working for both a local biotech company, Biofilm, and the pharmaceutical company, Pfizer. Upon completion of my undergraduate degree, I began a Ph.D., studying the roles of anti-glycolipid antibodies in autoimmune neuropathies, with Prof. Hugh Willison at the University of Glasgow.

After my Ph.D. I began my postdoctoral research at the University of Glasgow in the Laboratory of Immune Cell Visualisation and Examination (LIVE) under Profs James Brewer and Paul Garside. My research in this laboratory focussed on the roles of the immune system during autoimmune diseases and infections with a particular emphasis on studying the dynamics of these processes using multiphoton microscopy.

Following on from this work I took up a position at the MRC-University of Glasgow Centre for Virus Research to develop models as part of the COVID-19 Drug-Screening and Resistance Hub (CRUSH).

Research interests

I first developed an interest in the role of the immune system in disease during my Ph.D. where I created a series of anti-glycolipid antibodies for studying paralytic autoimmune neuropathies. Following on from my PhD, I was keen to expand my knowledge of immunology further and decided to join the Laboratory of Immune Cell Visualisation and Examination (LIVE). As part of LIVE, I was able to study both the formation of the immune response as well as its dysregulation during infection and disease.

An area of particular interest has been the development of the immune response in host organisms. This interest led me to take up a position in the COVID-19 Drug-Screening and Resistance Hub (CRUSH) at the MRC-University of Glasgow Centre for Virus Research. As part of CRUSH I am developing animal models that can be used to for both studying SARS-CoV-2 infection as well as the development of new treatments.

 

Publications

List by: Type | Date

Jump to: 2025 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2016 | 2015 | 2014 | 2013
Number of items: 18.

2025

Meehan, G. R. et al. (2025) Spermidine suppresses DC activation via eIF5A hypusination and metabolic adaptation. Discovery Immunology, (doi: 10.1093/discim/kyaf009) (Accepted for Publication)

Furnon, W. et al. (2025) Phenotypic evolution of SARS-CoV-2 spike during the COVID-19 pandemic. Nature Microbiology, 10, pp. 77-93. (doi: 10.1038/s41564-024-01878-5) (PMID:39753670) (PMCID:PMC11726466)

2023

Meehan, G. R. et al. (2023) Phenotyping the virulence of SARS-CoV-2 variants in hamsters by digital pathology and machine learning. PLoS Pathogens, 19(11), e1011589. (doi: 10.1371/journal.ppat.1011589) (PMID:37934791) (PMCID:PMC10656012)

2022

Meehan, Gavin R. ORCID logoORCID: https://orcid.org/0000-0001-9855-6565, Scales, Hannah E. ORCID logoORCID: https://orcid.org/0000-0002-4247-2802, McInnes, Iain B. ORCID logoORCID: https://orcid.org/0000-0002-6462-4280, Brewer, James M. ORCID logoORCID: https://orcid.org/0000-0001-7933-0915 and Garside, Paul ORCID logoORCID: https://orcid.org/0000-0001-5944-0287 (2022) Orally administered antigen can reduce or exacerbate pathology in an animal model of inflammatory arthritis dependent upon the timing of administration. Immunotherapy Advances, 2(1), ltac020. (doi: 10.1093/immadv/ltac020) (PMID:36268500) (PMCID:PMC9579813)

2021

Meehan, G. R. et al. (2021) Preclinical models of arthritis for studying immunotherapy and immune tolerance. Annals of the Rheumatic Diseases, 80(10), pp. 1268-1277. (doi: 10.1136/annrheumdis-2021-220043) (PMID:34380700)

2020

Cunningham, Madeleine E. ORCID logoORCID: https://orcid.org/0000-0002-7545-6868, Meehan, Gavin R. ORCID logoORCID: https://orcid.org/0000-0001-9855-6565, Robinson, Sophie, Yao, Denggao, McGonigal, Rhona ORCID logoORCID: https://orcid.org/0000-0001-9571-2526 and Willison, Hugh J. ORCID logoORCID: https://orcid.org/0000-0002-5997-1683 (2020) Perisynaptic Schwann cells phagocytose nerve terminal debris in a mouse model of Guillain-Barré syndrome. Journal of the Peripheral Nervous System, 25(2), pp. 143-151. (doi: 10.1111/jns.12373) (PMID:32250537)

Meehan, Gavin R. ORCID logoORCID: https://orcid.org/0000-0001-9855-6565, Scales, Hannah E. ORCID logoORCID: https://orcid.org/0000-0002-4247-2802, Osii, Rowland, De Niz, Mariana, Lawton, Jennifer C., Marti, Matthias ORCID logoORCID: https://orcid.org/0000-0003-1040-9566, Garside, Paul ORCID logoORCID: https://orcid.org/0000-0001-5944-0287, Craig, Alister and Brewer, James M. ORCID logoORCID: https://orcid.org/0000-0001-7933-0915 (2020) Developing a xenograft model of human vasculature in the mouse ear pinna. Scientific Reports, 10, 2058. (doi: 10.1038/s41598-020-58650-y) (PMID:32029768) (PMCID:PMC7004987)

2019

De Niz, Mariana, Meehan, Gavin R. ORCID logoORCID: https://orcid.org/0000-0001-9855-6565 and Tavares, Joana (2019) Intravital microscopy: imaging host‐parasite interactions in lymphoid organs. Cellular Microbiology, 21(12), e13117. (doi: 10.1111/cmi.13117) (PMID:31512335)

De Niz, Mariana, Meehan, Gavin R. ORCID logoORCID: https://orcid.org/0000-0001-9855-6565, Brancucci, Nicolas M.B. ORCID logoORCID: https://orcid.org/0000-0003-0655-3266, Marti, Matthias ORCID logoORCID: https://orcid.org/0000-0003-1040-9566, Rotureau, Brice, Figueiredo, Luisa M. and Frischknecht, Friedrich (2019) Intravital imaging of host-parasite interactions in skin and adipose tissues. Cellular Microbiology, 21(5), e13023. (doi: 10.1111/cmi.13023) (PMID:30825872)

Hayes, A. J. et al. (2019) Spatiotemporal modeling of the key migratory events during the initiation of adaptive immunity. Frontiers in Immunology, 10, 598. (doi: 10.3389/fimmu.2019.00598) (PMID:31024523) (PMCID:PMC6460458)

2018

Scales, H. E. et al. (2018) A novel cellular pathway of antigen presentation and CD4 T cell activation in vivo. Frontiers in Immunology, 9, 2684. (doi: 10.3389/fimmu.2018.02684)

Meehan, Gavin R. ORCID logoORCID: https://orcid.org/0000-0001-9855-6565, McGonigal, Rhona ORCID logoORCID: https://orcid.org/0000-0001-9571-2526, Cunningham, Madeleine E. ORCID logoORCID: https://orcid.org/0000-0002-7545-6868, Wang, Yuzhong, Barrie, Jennifer A., Halstead, Susan K., Gourlay, Dawn, Yao, Denggao and Willison, Hugh J. ORCID logoORCID: https://orcid.org/0000-0002-5997-1683 (2018) Differential binding patterns of anti-sulfatide antibodies to glial membranes. Journal of Neuroimmunology, 323, pp. 28-35. (doi: 10.1016/j.jneuroim.2018.07.004) (PMID:30196830) (PMCID:PMC6134133)

Noonan, J. et al. (2018) In vivo multiplex molecular imaging of vascular inflammation using surface-enhanced Raman spectroscopy. Theranostics, 8(22), pp. 6195-6209. (doi: 10.7150/thno.28665) (PMID:30613292) (PMCID:PMC6299693)

2016

Cunningham, Madeleine ORCID logoORCID: https://orcid.org/0000-0002-7545-6868, McGonigal, Rhona ORCID logoORCID: https://orcid.org/0000-0001-9571-2526, Meehan, Gavin R. ORCID logoORCID: https://orcid.org/0000-0001-9855-6565, Barrie, Jennifer A., Yao, Denggao, Halstead, Susan K. and Willison, Hugh J. ORCID logoORCID: https://orcid.org/0000-0002-5997-1683 (2016) Anti-ganglioside antibodies are removed from circulation in mice by neuronal endocytosis. Brain, 139(6), pp. 1657-1665. (doi: 10.1093/brain/aww056) (PMID:27017187) (PMCID:PMC4892750)

Meehan, Gavin ORCID logoORCID: https://orcid.org/0000-0001-9855-6565 (2016) Glycolipids in GBS: from basic science to clinical interface. In: Willison, Hugh J. and Goodfellow, John (eds.) GBS100: Celebrating a Century of Progress in Guillain-Barré Syndrome. Peripheral Nerve Society: San Diego, CA, pp. 327-333. ISBN 9780997510300

2015

Delmont, Emilien, Robb, Henry, Davidson, Amy, Halstead, Susan, Yao, Denggao, Meehan, Gavin R. ORCID logoORCID: https://orcid.org/0000-0001-9855-6565 and Willison, Hugh ORCID logoORCID: https://orcid.org/0000-0002-5997-1683 (2015) Prospective study comparing enzyme-linked immunosorbent assay and glycoarray assay to detect antiglycolipid antibodies in a routine diagnostic neuroimmunology laboratory setting. Clinical and Experimental Neuroimmunology, 6(2), pp. 175-182. (doi: 10.1111/cen3.12193)

2014

Yao, D. et al. (2014) Neuronal expression of galnac transferase is sufficient to prevent the age-related neurodegenerative phenotype of complex ganglioside-deficient mice. Journal of Neuroscience, 34(3), pp. 880-891. (doi: 10.1523/JNEUROSCI.3996-13.2014)

2013

Rupp, Angie, Yao, Denggao, Meehan, Gavin R. ORCID logoORCID: https://orcid.org/0000-0001-9855-6565 and Willison, Hugh J. ORCID logoORCID: https://orcid.org/0000-0002-5997-1683 (2013) Thy-1 Mice Lend Themselves for the Modelling of Anti-ganglioside Antibody-mediated Disorders. PNS Biennial Meeting of the Peripheral Nerve Society, St Malo, France, 11-14 Jun 2013.

This list was generated on Sun Jun 15 18:57:19 2025 BST.
Jump to: Articles | Book Sections | Conference or Workshop Item
Number of items: 18.

Articles

Meehan, G. R. et al. (2025) Spermidine suppresses DC activation via eIF5A hypusination and metabolic adaptation. Discovery Immunology, (doi: 10.1093/discim/kyaf009) (Accepted for Publication)

Furnon, W. et al. (2025) Phenotypic evolution of SARS-CoV-2 spike during the COVID-19 pandemic. Nature Microbiology, 10, pp. 77-93. (doi: 10.1038/s41564-024-01878-5) (PMID:39753670) (PMCID:PMC11726466)

Meehan, G. R. et al. (2023) Phenotyping the virulence of SARS-CoV-2 variants in hamsters by digital pathology and machine learning. PLoS Pathogens, 19(11), e1011589. (doi: 10.1371/journal.ppat.1011589) (PMID:37934791) (PMCID:PMC10656012)

Meehan, Gavin R. ORCID logoORCID: https://orcid.org/0000-0001-9855-6565, Scales, Hannah E. ORCID logoORCID: https://orcid.org/0000-0002-4247-2802, McInnes, Iain B. ORCID logoORCID: https://orcid.org/0000-0002-6462-4280, Brewer, James M. ORCID logoORCID: https://orcid.org/0000-0001-7933-0915 and Garside, Paul ORCID logoORCID: https://orcid.org/0000-0001-5944-0287 (2022) Orally administered antigen can reduce or exacerbate pathology in an animal model of inflammatory arthritis dependent upon the timing of administration. Immunotherapy Advances, 2(1), ltac020. (doi: 10.1093/immadv/ltac020) (PMID:36268500) (PMCID:PMC9579813)

Meehan, G. R. et al. (2021) Preclinical models of arthritis for studying immunotherapy and immune tolerance. Annals of the Rheumatic Diseases, 80(10), pp. 1268-1277. (doi: 10.1136/annrheumdis-2021-220043) (PMID:34380700)

Cunningham, Madeleine E. ORCID logoORCID: https://orcid.org/0000-0002-7545-6868, Meehan, Gavin R. ORCID logoORCID: https://orcid.org/0000-0001-9855-6565, Robinson, Sophie, Yao, Denggao, McGonigal, Rhona ORCID logoORCID: https://orcid.org/0000-0001-9571-2526 and Willison, Hugh J. ORCID logoORCID: https://orcid.org/0000-0002-5997-1683 (2020) Perisynaptic Schwann cells phagocytose nerve terminal debris in a mouse model of Guillain-Barré syndrome. Journal of the Peripheral Nervous System, 25(2), pp. 143-151. (doi: 10.1111/jns.12373) (PMID:32250537)

Meehan, Gavin R. ORCID logoORCID: https://orcid.org/0000-0001-9855-6565, Scales, Hannah E. ORCID logoORCID: https://orcid.org/0000-0002-4247-2802, Osii, Rowland, De Niz, Mariana, Lawton, Jennifer C., Marti, Matthias ORCID logoORCID: https://orcid.org/0000-0003-1040-9566, Garside, Paul ORCID logoORCID: https://orcid.org/0000-0001-5944-0287, Craig, Alister and Brewer, James M. ORCID logoORCID: https://orcid.org/0000-0001-7933-0915 (2020) Developing a xenograft model of human vasculature in the mouse ear pinna. Scientific Reports, 10, 2058. (doi: 10.1038/s41598-020-58650-y) (PMID:32029768) (PMCID:PMC7004987)

De Niz, Mariana, Meehan, Gavin R. ORCID logoORCID: https://orcid.org/0000-0001-9855-6565 and Tavares, Joana (2019) Intravital microscopy: imaging host‐parasite interactions in lymphoid organs. Cellular Microbiology, 21(12), e13117. (doi: 10.1111/cmi.13117) (PMID:31512335)

De Niz, Mariana, Meehan, Gavin R. ORCID logoORCID: https://orcid.org/0000-0001-9855-6565, Brancucci, Nicolas M.B. ORCID logoORCID: https://orcid.org/0000-0003-0655-3266, Marti, Matthias ORCID logoORCID: https://orcid.org/0000-0003-1040-9566, Rotureau, Brice, Figueiredo, Luisa M. and Frischknecht, Friedrich (2019) Intravital imaging of host-parasite interactions in skin and adipose tissues. Cellular Microbiology, 21(5), e13023. (doi: 10.1111/cmi.13023) (PMID:30825872)

Hayes, A. J. et al. (2019) Spatiotemporal modeling of the key migratory events during the initiation of adaptive immunity. Frontiers in Immunology, 10, 598. (doi: 10.3389/fimmu.2019.00598) (PMID:31024523) (PMCID:PMC6460458)

Scales, H. E. et al. (2018) A novel cellular pathway of antigen presentation and CD4 T cell activation in vivo. Frontiers in Immunology, 9, 2684. (doi: 10.3389/fimmu.2018.02684)

Meehan, Gavin R. ORCID logoORCID: https://orcid.org/0000-0001-9855-6565, McGonigal, Rhona ORCID logoORCID: https://orcid.org/0000-0001-9571-2526, Cunningham, Madeleine E. ORCID logoORCID: https://orcid.org/0000-0002-7545-6868, Wang, Yuzhong, Barrie, Jennifer A., Halstead, Susan K., Gourlay, Dawn, Yao, Denggao and Willison, Hugh J. ORCID logoORCID: https://orcid.org/0000-0002-5997-1683 (2018) Differential binding patterns of anti-sulfatide antibodies to glial membranes. Journal of Neuroimmunology, 323, pp. 28-35. (doi: 10.1016/j.jneuroim.2018.07.004) (PMID:30196830) (PMCID:PMC6134133)

Noonan, J. et al. (2018) In vivo multiplex molecular imaging of vascular inflammation using surface-enhanced Raman spectroscopy. Theranostics, 8(22), pp. 6195-6209. (doi: 10.7150/thno.28665) (PMID:30613292) (PMCID:PMC6299693)

Cunningham, Madeleine ORCID logoORCID: https://orcid.org/0000-0002-7545-6868, McGonigal, Rhona ORCID logoORCID: https://orcid.org/0000-0001-9571-2526, Meehan, Gavin R. ORCID logoORCID: https://orcid.org/0000-0001-9855-6565, Barrie, Jennifer A., Yao, Denggao, Halstead, Susan K. and Willison, Hugh J. ORCID logoORCID: https://orcid.org/0000-0002-5997-1683 (2016) Anti-ganglioside antibodies are removed from circulation in mice by neuronal endocytosis. Brain, 139(6), pp. 1657-1665. (doi: 10.1093/brain/aww056) (PMID:27017187) (PMCID:PMC4892750)

Delmont, Emilien, Robb, Henry, Davidson, Amy, Halstead, Susan, Yao, Denggao, Meehan, Gavin R. ORCID logoORCID: https://orcid.org/0000-0001-9855-6565 and Willison, Hugh ORCID logoORCID: https://orcid.org/0000-0002-5997-1683 (2015) Prospective study comparing enzyme-linked immunosorbent assay and glycoarray assay to detect antiglycolipid antibodies in a routine diagnostic neuroimmunology laboratory setting. Clinical and Experimental Neuroimmunology, 6(2), pp. 175-182. (doi: 10.1111/cen3.12193)

Yao, D. et al. (2014) Neuronal expression of galnac transferase is sufficient to prevent the age-related neurodegenerative phenotype of complex ganglioside-deficient mice. Journal of Neuroscience, 34(3), pp. 880-891. (doi: 10.1523/JNEUROSCI.3996-13.2014)

Book Sections

Meehan, Gavin ORCID logoORCID: https://orcid.org/0000-0001-9855-6565 (2016) Glycolipids in GBS: from basic science to clinical interface. In: Willison, Hugh J. and Goodfellow, John (eds.) GBS100: Celebrating a Century of Progress in Guillain-Barré Syndrome. Peripheral Nerve Society: San Diego, CA, pp. 327-333. ISBN 9780997510300

Conference or Workshop Item

Rupp, Angie, Yao, Denggao, Meehan, Gavin R. ORCID logoORCID: https://orcid.org/0000-0001-9855-6565 and Willison, Hugh J. ORCID logoORCID: https://orcid.org/0000-0002-5997-1683 (2013) Thy-1 Mice Lend Themselves for the Modelling of Anti-ganglioside Antibody-mediated Disorders. PNS Biennial Meeting of the Peripheral Nerve Society, St Malo, France, 11-14 Jun 2013.

This list was generated on Sun Jun 15 18:57:19 2025 BST.

Research datasets

Jump to: 2024 | 2023
Number of items: 2.

2024

Furnon, W. , Cowton, V. M., De Lorenzo, G. , Orton, R. , Herder, V. , Cantoni, D. , Ilia, G., Correa Mendonca, D. , Kerr, K., Allan, J., Upfold, N. , Meehan, G. R. , Bakshi, S., Das, U. R., Molina Arias, S., McElwee, M., Little, S., Logan, N., Kwok, K. , Smollett, K. , Willett, B. , Da Silva Filipe, A. , Robertson, D. L. , Grove, J. , Patel, A. H. and Palmarini, M. (2024) Phenotypic evolution of SARS-CoV-2 spike throughout the COVID-19 pandemic. [Data Collection]

2023

Meehan, G. , Herder, V. , Allan, J., Huang, X., Kerr, K., Correa Mendonca, D. , Ilia, G., Wright, D. , Nomikou, K., Gu, Q. , Molina Arias, S., Hansmann, F., Hardas, A., Attipa, C., De Lorenzo, G. , Cowton, V., Upfold, N. , Palmalux, N., Brown, J., Barclay, W., Da Silva Filipe, A. , Furnon, W. , Patel, A. and Palmarini, M. (2023) Phenotyping the virulence of SARS-CoV-2 variants in hamsters by digital pathology and machine learning. [Data Collection]

This list was generated on Sun Jun 15 12:35:14 2025 BST.