Professor David Bhella

  • Professor of Structural Virology (Virology)

telephone: 01413303685
email: David.Bhella@glasgow.ac.uk
pronouns: He/him/his

Centre for Virus Research, Sir Michael Stoker Building, 464 Bearsden Road, Glasgow, G61 1qh

Import to contacts

ORCID iDhttps://orcid.org/0000-0003-2096-8310

Research interests

CVR logoVirus image CVR Supporting COVID-19 Research Response

The structural components of viruses represent an intriguing area of study for the structural biologist. In their replication cycle, viruses must generate a protective shell (or capsid) to ferry their genome between hosts. These structural proteins may also be required to facilitate entry to and exit from the host cell, as well as packaging the genome and the necessary functional proteins. In many cases structural proteins are also involved in replication and integration of the viral genome. Thus virus particles are dynamic entities, molecular machines evolved to provide a robust protective shell for the genome and capable of undergoing dramatic conformational changes upon infection of a host cell and in response to specific environmental stimuli.

The fact that many viruses generate their capsids from only one or two protein species makes them all the more remarkable. Viruses attain this level of economy by assembling their capsids in a highly symmetrical manner making these structures not only scientifically interesting but also beautiful.

This group applies the techniques of electron-cryomicroscopy and image analysis to the study of viruses and viral proteins. We have access to state of the art instrumentation through the Scottish centre for macromolecular imaging (SCMI). We also have facilities for correlative cryo-fluorescence imaging, high-pressure freezing, automated freeze substitution and cryo-ultramicrotomy. The establishment of these capabilities within a dedicated virus research laboratory gives us an exciting opportunity to visualise the process of virus infection at cellular scale and macromolecular resolution.

We are currently engaged in research into caliciviruses, coronaviruses, influenzaviruses and pneumoviruses. Our research focusses on viral entry processes, evolution in the face of host immunity and virion assembly.

Publications

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Number of items: 55.

2024

Lewis, Charlotte B., Sherry, Lee, Conley, Michaela J. ORCID logoORCID: https://orcid.org/0000-0002-3457-1149, Nakashima, Masaaki, Akbar, Shirin, Govindan, Nithya, Hosie, Margaret J. ORCID logoORCID: https://orcid.org/0000-0002-4313-5023 and Bhella, David ORCID logoORCID: https://orcid.org/0000-0003-2096-8310 (2024) Conformational flexibility in capsids encoded by the Caliciviridae. Viruses, 16(12), 1835. (doi: 10.3390/v16121835) (PMID:39772145) (PMCID:PMC11680396)

2023

Weckener, Miriam, Woodward, Laura S., Clarke, Bradley R., Liu, Huanting, Ward, Philip N., Le Bas, Audrey, Bhella, David ORCID logoORCID: https://orcid.org/0000-0003-2096-8310, Whitfield, Chris and Naismith, James H. (2023) The lipid linked oligosaccharide polymerase Wzy and its regulating co-polymerase, Wzz, from enterobacterial common antigen biosynthesis form a complex. Open Biology, 13(3), 220373. (doi: 10.1098/rsob.220373) (PMID:36944376) (PMCID:PMC10030265)

2022

Haney, Joanne, Vijayakrishnan, Swetha ORCID logoORCID: https://orcid.org/0000-0002-1895-1272, Streetley, James ORCID logoORCID: https://orcid.org/0000-0001-7808-605X, Dee, Kieran, Goldfarb, Daniel Max, Clarke, Mairi ORCID logoORCID: https://orcid.org/0000-0002-9658-4308, Mullin, Margaret, Carter, Stephen D. ORCID logoORCID: https://orcid.org/0000-0002-4237-4276, Bhella, David ORCID logoORCID: https://orcid.org/0000-0003-2096-8310 and Murcia, Pablo R. ORCID logoORCID: https://orcid.org/0000-0002-4352-394X (2022) Coinfection by influenza A virus and respiratory syncytial virus produces hybrid virus particles. Nature Microbiology, 7(11), pp. 1879-1890. (doi: 10.1038/s41564-022-01242-5) (PMID:36280786)

Conley, M. J. et al. (2022) Helical ordering of envelope associated proteins and glycoproteins in respiratory syncytial virus. EMBO Journal, 41(3), e109728. (doi: 10.15252/embj.2021109728) (PMID:34935163) (PMCID:PMC8804925)

Plucinski, Alexander, Pavlovic, Marko, Clarke, Mairi ORCID logoORCID: https://orcid.org/0000-0002-9658-4308, Bhella, David ORCID logoORCID: https://orcid.org/0000-0003-2096-8310 and Schmidt, Bernhard V.K.J. ORCID logoORCID: https://orcid.org/0000-0002-3580-7053 (2022) Stimuli-responsive aggregation of high molar mass poly(N,N-diethylacrylamide)-b-poly(4-acryloylmorpholine) in tetrahydrofuran. Macromolecular Rapid Communications, 43(3), 2100656. (doi: 10.1002/marc.202100656) (PMID:34783099)

Loundras, Eleni-Anna, Streetley, James ORCID logoORCID: https://orcid.org/0000-0001-7808-605X, Herod, Morgan R., Thompson, Rebecca, Harris, Mark, Bhella, David ORCID logoORCID: https://orcid.org/0000-0003-2096-8310 and Stonehouse, Nicola J. (2022) Higher-order structures of the foot-and-mouth disease virus RNA-dependent RNA polymerase required for genome replication. Communications Biology, 5, 61. (doi: 10.1038/s42003-021-02989-z) (PMID:35039618) (PMCID:PMC8764057)

2021

Mahindra, A. et al. (2021) Peptides derived from the SARS-CoV-2 receptor binding motif bind to ACE2 but do not block ACE2-mediated host cell entry or pro-inflammatory cytokine induction. PLoS ONE, 16(11), e0260283. (doi: 10.1371/journal.pone.0260283) (PMID:34793553) (PMCID:PMC8601423)

Morgan, D. C. et al. (2021) Stapled ACE2 peptidomimetics designed to target the SARS-CoV-2 spike protein do not prevent virus internalisation. Peptide Science, 113(4), e24217. (doi: 10.1002/pep2.24217) (PMID:33615115) (PMCID:PMC7883042)

Sutherland, Hazel, Conley, Michaela J. ORCID logoORCID: https://orcid.org/0000-0002-3457-1149, Emmott, Edward, Streetley, James ORCID logoORCID: https://orcid.org/0000-0001-7808-605X, Goodfellow, Ian G. and Bhella, David ORCID logoORCID: https://orcid.org/0000-0003-2096-8310 (2021) The cryo-EM structure of vesivirus 2117 highlights functional variations in entry pathways for viruses in different clades of the vesivirus genus. Journal of Virology, 95(13), e0028221. (doi: 10.1128/JVI.00282-21) (PMID:33853966)

2020

Vijayakrishnan, Swetha ORCID logoORCID: https://orcid.org/0000-0002-1895-1272, McElwee, Marion, Loney, Colin ORCID logoORCID: https://orcid.org/0000-0002-0508-1781, Rixon, Frazer and Bhella, David ORCID logoORCID: https://orcid.org/0000-0003-2096-8310 (2020) In situ structure of virus capsids within cell nuclei by correlative light and cryo-electron tomography. Scientific Reports, 10, 17596. (doi: 10.1038/s41598-020-74104-x) (PMID:33077791) (PMCID:PMC7572381)

Guzik, T. J. et al. (2020) COVID-19 and the cardiovascular system: implications for risk assessment, diagnosis, and treatment options. Cardiovascular Research, 116(10), pp. 1666-1687. (doi: 10.1093/cvr/cvaa106) (PMID:32352535) (PMCID:PMC7197627)

2019

Bhella, David ORCID logoORCID: https://orcid.org/0000-0003-2096-8310 (2019) Cryo-electron microscopy: an introduction to the technique, and considerations when working to establish a national facility. Biophysical Reviews, 11(4), pp. 515-519. (doi: 10.1007/s12551-019-00571-w) (PMID:31359340) (PMCID:PMC6682334)

Conley, M.J. ORCID logoORCID: https://orcid.org/0000-0002-3457-1149 and Bhella, D. ORCID logoORCID: https://orcid.org/0000-0003-2096-8310 (2019) Asymmetric analysis reveals novel virus capsid features. Biophysical Reviews, 11(4), pp. 603-609. (doi: 10.1007/s12551-019-00572-9) (PMID:31342264) (PMCID:PMC6682188)

Conley, Michaela J. ORCID logoORCID: https://orcid.org/0000-0002-3457-1149, McElwee, Marion, Azmi, Liyana, Gabrielsen, Mads ORCID logoORCID: https://orcid.org/0000-0002-9848-2276, Byron, Olwyn ORCID logoORCID: https://orcid.org/0000-0001-7857-4520, Goodfellow, Ian G. and Bhella, David ORCID logoORCID: https://orcid.org/0000-0003-2096-8310 (2019) Calicivirus VP2 forms a portal-like assembly following receptor engagement. Nature, 565(7739), pp. 377-381. (doi: 10.1038/s41586-018-0852-1) (PMID:30626974)

2018

Ho, Kok Lian, Gabrielsen, Mads, Beh, Poay Ling, Kueh, Chare Li, Qiu Xian, Thong, Streetley, James ORCID logoORCID: https://orcid.org/0000-0001-7808-605X, Tan, Wen Siang and Bhella, David ORCID logoORCID: https://orcid.org/0000-0003-2096-8310 (2018) Structure of the Macrobrachium rosenbergii nodavirus: a new genus within the Nodaviridae? PLoS Biology, 16(10), e3000038. (doi: 10.1371/journal.pbio.3000038) (PMID:30346944) (PMCID:PMC6211762)

McElwee, Marion, Vijayakrishnan, Swetha ORCID logoORCID: https://orcid.org/0000-0002-1895-1272, Rixon, Frazer and Bhella, David ORCID logoORCID: https://orcid.org/0000-0003-2096-8310 (2018) Structure of the herpes-simplex virus portal-vertex. PLoS Biology, 16(6), e2006191. (doi: 10.1371/journal.pbio.2006191) (PMID:29924793) (PMCID:PMC6028144)

2017

Burns, Andrew M. and Bhella, David ORCID logoORCID: https://orcid.org/0000-0003-2096-8310 (2017) Killer microbes in movies. Microbiology Today, 44(4), pp. 162-165.

Barski, Michal, Brennan, Benjamin ORCID logoORCID: https://orcid.org/0000-0003-4707-726X, Miller, Ona K., Potter, Jane A., Vijayakrishnan, Swetha ORCID logoORCID: https://orcid.org/0000-0002-1895-1272, Bhella, David ORCID logoORCID: https://orcid.org/0000-0003-2096-8310, Naismith, James H., Elliott, Richard M. and Schwarz-Linek, Ulrich (2017) Rift Valley fever phlebovirus NSs protein core domain structure suggests molecular basis for nuclear filaments. eLife, 6, e29236. (doi: 10.7554/elife.29236) (PMID:28915104) (PMCID:PMC5601994)

Ho, Kok Lian, Kueh, Chare Li, Beh, Poay Ling, Tan, Wen Siang and Bhella, David ORCID logoORCID: https://orcid.org/0000-0003-2096-8310 (2017) Cryo-electron microscopy structure of the Macrobrachium rosenbergii nodavirus capsid at 7 angstroms resolution. Scientific Reports, 7, 2083. (doi: 10.1038/s41598-017-02292-0) (PMID:28522842) (PMCID:PMC5437026)

Conley, Michaela ORCID logoORCID: https://orcid.org/0000-0002-3457-1149, Emmott, Edward, Orton, Richard ORCID logoORCID: https://orcid.org/0000-0002-3389-4325, Taylor, David, Carneiro, Daniel G., Murata, Kazuyoshi, Goodfellow, Ian G., Hansman, Grant S. and Bhella, David ORCID logoORCID: https://orcid.org/0000-0003-2096-8310 (2017) Vesivirus 2117 capsids more closely resemble sapovirus and lagovirus particles than other known vesivirus structures. Journal of General Virology, 98(1), pp. 68-76. (doi: 10.1099/jgv.0.000658) (PMID:27902397) (PMCID:PMC537039)

2016

Dadonaite, Bernadeta, Vijayakrishnan, Swetha ORCID logoORCID: https://orcid.org/0000-0002-1895-1272, Fodor, Ervin, Bhella, David ORCID logoORCID: https://orcid.org/0000-0003-2096-8310 and Hutchinson, Edward C. ORCID logoORCID: https://orcid.org/0000-0003-3673-9096 (2016) Filamentous influenza viruses. Journal of General Virology, 97(8), pp. 1755-1764. (doi: 10.1099/jgv.0.000535) (PMID:27365089)

2015

Bhella, David ORCID logoORCID: https://orcid.org/0000-0003-2096-8310 (2015) The role of cellular adhesion molecules in virus attachment and entry. Philosophical Transactions of the Royal Society B: Biological Sciences, 370(1661), (doi: 10.1098/rstb.2014.0035) (PMID:25533093) (PMCID:PMC4275905)

Fan, Wan H., Robertson, Ashley P.E., McElwee, Marion, Bhella, David ORCID logoORCID: https://orcid.org/0000-0003-2096-8310, Rixon, Frazer J. and Lauder, Rebecca (2015) The large tegument protein pUL36 is essential for formation of the capsid vertex-specific component at the capsid-tegument interface of herpes simplex virus 1. Journal of Virology, 89(3), pp. 1502-1511. (doi: 10.1128/JVI.02887-14) (PMID:25410861) (PMCID:PMC4300765)

McGonigle, Richard, Yap, Wei Boon, Ong, Swee Tin, Gatherer, Derek, Bakker, Saskia E., Tan, Wen Siang and Bhella, David ORCID logoORCID: https://orcid.org/0000-0003-2096-8310 (2015) An N-terminal extension to the hepatitis B virus core protein forms a poorly ordered trimeric spike in assembled virus-like particles. Journal of Structural Biology, 189(2), pp. 73-80. (doi: 10.1016/j.jsb.2014.12.006) (PMID:25557498) (PMCID:PMC4318616)

2014

Hacker, Christian, Howell, Matthew, Bhella, David ORCID logoORCID: https://orcid.org/0000-0003-2096-8310 and Lucocq, John (2014) Strategies for maximizing ATP supply in the microsporidian Encephalitozoon cuniculi: direct binding of mitochondria to the parasitophorous vacuole and clustering of the mitochondrial porin VDAC. Cellular Microbiology, 16(4), pp. 565-579. (doi: 10.1111/cmi.12240) (PMID:24245785) (PMCID:PMC4233961)

2013

Bakker, S. E., Duquerroy, S., Galloux, M., Loney, C., Conner, E., Eleouet, J.-F., Rey, F. A. and Bhella, D. ORCID logoORCID: https://orcid.org/0000-0003-2096-8310 (2013) The respiratory syncytial virus nucleoprotein–RNA complex forms a left-handed helical nucleocapsid. Journal of General Virology, 94(8), pp. 1734-1738. (doi: 10.1099/vir.0.053025-0) (PMID:23677789) (PMCID:PMC3749527)

Rihn, S.J. ORCID logoORCID: https://orcid.org/0000-0001-9495-4056, Wilson, S.J. ORCID logoORCID: https://orcid.org/0000-0002-6065-0895, Loman, N.J., Alim, M., Bakker, S.E., Bhella, D. ORCID logoORCID: https://orcid.org/0000-0003-2096-8310, Gifford, R.J., Rixon, F.J. and Bieniasz, P.D. (2013) Extreme genetic fragility of the HIV-1 capsid. PLoS Pathogens, 9(6), e1003461. (doi: 10.1371/journal.ppat.1003461) (PMID:23818857) (PMCID:PMC3688543)

Bhella, David ORCID logoORCID: https://orcid.org/0000-0003-2096-8310 and Bakker, Saskia E. (2013) Pretty Nasty, symmetry in virus architecture. Biochemist, 35(2), pp. 14-19.

Vijayakrishnan, S. ORCID logoORCID: https://orcid.org/0000-0002-1895-1272, Loney, C. ORCID logoORCID: https://orcid.org/0000-0002-0508-1781, Jackson, D., Suphamungmee, W., Rixon, F.J. and Bhella, D. ORCID logoORCID: https://orcid.org/0000-0003-2096-8310 (2013) Cryotomography of budding influenza a virus reveals filaments with diverse morphologies that mostly do not bear a genome at their distal end. PLoS Pathogens, 9(6), e1003413. (doi: 10.1371/journal.ppat.1003413)

2012

Schmid, Michael F., Hecksel, Corey W., Rochat, Ryan H., Bhella, David ORCID logoORCID: https://orcid.org/0000-0003-2096-8310, Chiu, Wah and Rixon, Frazer J. (2012) A tail-like assembly at the portal vertex in intact herpes simplex type-1 virions. PLoS Pathogens, 8(10), e1002961. (doi: 10.1371/journal.ppat.1002961) (PMID:23055933) (PMCID:PMC3464221)

2011

Bhella, David ORCID logoORCID: https://orcid.org/0000-0003-2096-8310 and Goodfellow, Ian G. (2011) The cryo-electron microscopy structure of feline calicivirus bound to junctional adhesion molecule A at 9-angstrom resolution reveals receptor-induced flexibility and two distinct conformational changes in the capsid protein VP1. Journal of Virology, 85(21), pp. 11381-11390. (doi: 10.1128/JVI.05621-11) (PMID:21865392) (PMCID:PMC3194967)

Neuman, B. W. et al. (2011) A structural analysis of M protein in coronavirus assembly and morphology. Journal of Structural Biology, 174(1), pp. 11-22. (doi: 10.1016/j.jsb.2010.11.021) (PMID:21130884)

2010

Vijayakrishnan, S. ORCID logoORCID: https://orcid.org/0000-0002-1895-1272, Kelly, S.M., Gilbert, R.J.C., Callow, P., Bhella, D. ORCID logoORCID: https://orcid.org/0000-0003-2096-8310, Forsyth, T., Lindsay, J.G. and Byron, O. (2010) Solution structure and characterisation of the human pyruvate dehydrogenase complex core assembly. Journal of Molecular Biology, 399(1), pp. 71-93. (doi: 10.1016/j.jmb.2010.03.043) (PMID:20361979) (PMCID:PMC2880790)

Parsons, J.B., Frank, S., Bhella, D. ORCID logoORCID: https://orcid.org/0000-0003-2096-8310, Liang, M., Prentice, M.B., Mulvihill, D.P. and Warren, M.J. (2010) Synthesis of empty bacterial microcompartments, directed organelle protein incorporation, and evidence of filament-associated organelle movement. Molecular Cell, 38(2), pp. 305-315. (doi: 10.1016/j.molcel.2010.04.008) (PMID:20417607)

2009

Tawar, R.G. et al. (2009) Crystal structure of a nucleocapsid-like nucleoprotein-RNA complex of respiratory syncytial virus. Science, 326(5957), pp. 1279-1283. (doi: 10.1126/science.1177634)

Loney, C., Mottet-Osman, G., Roux, L. and Bhella, D. ORCID logoORCID: https://orcid.org/0000-0003-2096-8310 (2009) Paramyxovirus ultrastructure and genome packaging: cryo-electron tomography of Sendai virus. Journal of Virology, 83(16), pp. 8191-8197. (doi: 10.1128/JVI.00693-09)

Alba, R. et al. (2009) Identification of coagulation factor (F)X binding sites on the adenovirus serotype 5 hexon: effect of mutagenesis on FX interactions and gene transfer. Blood, 114(5), pp. 965-971. (doi: 10.1182/blood-2009-03-208835)

Greig, J.A. et al. (2009) Influence of Coagulation Factor X on In Vitro and In Vivo Gene Delivery by Adenovirus (Ad) 5, Ad35, and Chimeric Ad5/Ad35 Vectors. Molecular Therapy, 17(10), pp. 1683-1691. (doi: 10.1038/mt.2009.152)

2008

Bhella, D. ORCID logoORCID: https://orcid.org/0000-0003-2096-8310, Gatherer, D., Chaudhry, Y., Pink, R. and Goodfellow, I.G. (2008) Structural insights into calicivirus attachment and uncoating. Journal of Virology, 82(16), pp. 8051-8058. (doi: 10.1128/JVI.00550-08)

Waddington, S. et al. (2008) Adenovirus serotype 5 hexon mediates liver gene transfer. Cell, 132(3), pp. 397-409. (doi: 10.1016/j.cell.2008.01.016)

2007

Maclellan, K., Loney, C. ORCID logoORCID: https://orcid.org/0000-0002-0508-1781, Yeo, R.P. and Bhella, D. ORCID logoORCID: https://orcid.org/0000-0003-2096-8310 (2007) The 24-angstrom structure of respiratory syncytial virus nucleocapsid protein-RNA decameric rings. Journal of Virology, 81(17), pp. 9519-9524. (doi: 10.1128/JVI.00526-07)

Tran, T. et al. (2007) The nine C-terminal amino acids of the respiratory syncytial virus protein P are necessary and sufficient for binding to ribonucleoprotein complexes in which six ribonucleotides are contacted per N protein protomer. Journal of General Virology, 88(1), pp. 196-206. (doi: 10.1099/vir.0.82282-0)

Bhella, D. ORCID logoORCID: https://orcid.org/0000-0003-2096-8310 (2007) Measles virus nucleocapsid structure, conformational flexibility and the rule of six. In: Longhi, S. (ed.) Measles Virus Nucleoprotein. Series: Intrinsically disordered proteins. Nova Publishers, pp. 37-50. ISBN 9781606925218

Cao, Z., Bhella, D. ORCID logoORCID: https://orcid.org/0000-0003-2096-8310 and Lindsay, J.G. (2007) Reconstitution of the mitochondrial PrxII antioxidant defence pathway: General properties and factors affecting PrxII activity and oligomeric state. Journal of Molecular Biology, 372, pp. 1022-1033. (doi: 10.1016/j.jmb.2007.07.018)

Davidson, A.J. and Bhella, D. ORCID logoORCID: https://orcid.org/0000-0003-2096-8310 (2007) Comparative genome and virion structure. In: Arvin, A., Campadelli-Fiume, G. and Mocarski, E. (eds.) Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis. Cambridge University Press. ISBN 9780521827140

2006

Pettigrew, D.M., Williams, D.T., Kerrigan, D., Evans, D.J., Lea, S.M. and Bhella, D. ORCID logoORCID: https://orcid.org/0000-0003-2096-8310 (2006) Structural and functional insights into the interaction of echoviruses and decay-accelerating factor. Journal of Biological Chemistry, 281, pp. 5169-5177. (doi: 10.1074/jbc.M510362200)

2004

Bhella, D. ORCID logoORCID: https://orcid.org/0000-0003-2096-8310, Ralph, A. and Yeo, R.P. (2004) Conformational flexibility in recombinant measles virus nucleocapsids visualised by cryo-negative stain electron microscopy and real-space helical reconstruction. Journal of Molecular Biology, 340(2), pp. 319-331. (doi: 10.1016/j.jmb.2004.05.015)

Bhella, D. ORCID logoORCID: https://orcid.org/0000-0003-2096-8310, Goodfellow, I.G., Roversi, P., Pettigrew, D., Chaudhry, Y., Evans, D.J. and Lea, S.M. (2004) The structure of echovirus type 12 bound to a two-domain fragment of its cellular attachment protein decay-accelerating factor (CD 55). Journal of Biological Chemistry, 279, pp. 8325-8332. (doi: 10.1074/jbc.M311334200)

2003

Longhi, Sonia, Receveur-Bréchot, Véronique, Karlin, David, Johansson, Kenth, Darbon, Hervé, Bhella, David ORCID logoORCID: https://orcid.org/0000-0003-2096-8310, Yeo, Robert, Finet, Stéphanie and Canard, Bruno (2003) The C-terminal domain of the measles virus nucleoprotein is intrinsically disordered and folds upon binding to the C-terminal moiety of the phosphoprotein. Journal of Biological Chemistry, 278(20), pp. 18638-18648. (doi: 10.1074/jbc.M300518200)

Murphy, L.B., Loney, C. ORCID logoORCID: https://orcid.org/0000-0002-0508-1781, Murray, J., Bhella, D. ORCID logoORCID: https://orcid.org/0000-0003-2096-8310, Ashton, P. and Yeo, R.P. (2003) Investigations into the amino-terminal domain of the respiratory syncytial virus nucleocapsid protein reveal elements important for nucleocapsid formation and interaction with the phosphoprotein. Virology, 307(1), pp. 143-53. (doi: 10.1016/S0042-6822(02)00063-6)

2002

Bhella, D. ORCID logoORCID: https://orcid.org/0000-0003-2096-8310, Ralph, A., Murphy, L. and Yeo, R.P. (2002) Significant differences in nucleocapsid morphology within the Paramyxoviridae. Journal of General Virology, 83(8), pp. 1831-1839.

Clayton, R.F., Owsianka, A., Aitken, J., Graham, S., Bhella, D. ORCID logoORCID: https://orcid.org/0000-0003-2096-8310 and Patel, A.H. ORCID logoORCID: https://orcid.org/0000-0003-4600-2047 (2002) Analysis of antigenicity and topology of E2 glycoprotein present on recombinant hepatitis C virus-like particles. Journal of Virology, 76(18), p. 9562. (doi: 10.1128/jvi.76.18.9562.2002)

McCLelland, D.A., Aitken, J.D., Bhella, David ORCID logoORCID: https://orcid.org/0000-0003-2096-8310, McNab, David, Mitchell, Joyce, Kelly, S.M. ORCID logoORCID: https://orcid.org/0000-0002-3516-1387, Price, N.C. and Rixon, F.J. (2002) pH reduction as a trigger for dissociation of herpes simplex virus type 1 scaffolds. Journal of Virology, 76, pp. 7407-7417. (doi: 10.1128/VJI.76.15.7407-7417.2002)

2000

Bhella, D. ORCID logoORCID: https://orcid.org/0000-0003-2096-8310, Rixon, F.J. and Dargan, D.J. (2000) Cryomicroscopy of human cytomegalovirus virions reveals more densely packed genomic DNA than in herpes simplex virus type 1. Journal of Molecular Biology, 295(2), pp. 155-161. (doi: 10.1006/jmbi.1999.3344)

1999

AL-Khayat, H.A, Bhella, D. ORCID logoORCID: https://orcid.org/0000-0003-2096-8310, Kenney, J.M, Roth, J.F, Kingsman, A.J, Martin-Rendon, E. and Saibil, H.R (1999) Yeast Ty retrotransposons assemble into virus-like particles whose T-numbers depend on the C-terminal length of the capsid protein. Journal of Molecular Biology, 292(1), pp. 65-73. (doi: 10.1006/jmbi.1999.3055)

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Number of items: 55.

Articles

Lewis, Charlotte B., Sherry, Lee, Conley, Michaela J. ORCID logoORCID: https://orcid.org/0000-0002-3457-1149, Nakashima, Masaaki, Akbar, Shirin, Govindan, Nithya, Hosie, Margaret J. ORCID logoORCID: https://orcid.org/0000-0002-4313-5023 and Bhella, David ORCID logoORCID: https://orcid.org/0000-0003-2096-8310 (2024) Conformational flexibility in capsids encoded by the Caliciviridae. Viruses, 16(12), 1835. (doi: 10.3390/v16121835) (PMID:39772145) (PMCID:PMC11680396)

Weckener, Miriam, Woodward, Laura S., Clarke, Bradley R., Liu, Huanting, Ward, Philip N., Le Bas, Audrey, Bhella, David ORCID logoORCID: https://orcid.org/0000-0003-2096-8310, Whitfield, Chris and Naismith, James H. (2023) The lipid linked oligosaccharide polymerase Wzy and its regulating co-polymerase, Wzz, from enterobacterial common antigen biosynthesis form a complex. Open Biology, 13(3), 220373. (doi: 10.1098/rsob.220373) (PMID:36944376) (PMCID:PMC10030265)

Haney, Joanne, Vijayakrishnan, Swetha ORCID logoORCID: https://orcid.org/0000-0002-1895-1272, Streetley, James ORCID logoORCID: https://orcid.org/0000-0001-7808-605X, Dee, Kieran, Goldfarb, Daniel Max, Clarke, Mairi ORCID logoORCID: https://orcid.org/0000-0002-9658-4308, Mullin, Margaret, Carter, Stephen D. ORCID logoORCID: https://orcid.org/0000-0002-4237-4276, Bhella, David ORCID logoORCID: https://orcid.org/0000-0003-2096-8310 and Murcia, Pablo R. ORCID logoORCID: https://orcid.org/0000-0002-4352-394X (2022) Coinfection by influenza A virus and respiratory syncytial virus produces hybrid virus particles. Nature Microbiology, 7(11), pp. 1879-1890. (doi: 10.1038/s41564-022-01242-5) (PMID:36280786)

Conley, M. J. et al. (2022) Helical ordering of envelope associated proteins and glycoproteins in respiratory syncytial virus. EMBO Journal, 41(3), e109728. (doi: 10.15252/embj.2021109728) (PMID:34935163) (PMCID:PMC8804925)

Plucinski, Alexander, Pavlovic, Marko, Clarke, Mairi ORCID logoORCID: https://orcid.org/0000-0002-9658-4308, Bhella, David ORCID logoORCID: https://orcid.org/0000-0003-2096-8310 and Schmidt, Bernhard V.K.J. ORCID logoORCID: https://orcid.org/0000-0002-3580-7053 (2022) Stimuli-responsive aggregation of high molar mass poly(N,N-diethylacrylamide)-b-poly(4-acryloylmorpholine) in tetrahydrofuran. Macromolecular Rapid Communications, 43(3), 2100656. (doi: 10.1002/marc.202100656) (PMID:34783099)

Loundras, Eleni-Anna, Streetley, James ORCID logoORCID: https://orcid.org/0000-0001-7808-605X, Herod, Morgan R., Thompson, Rebecca, Harris, Mark, Bhella, David ORCID logoORCID: https://orcid.org/0000-0003-2096-8310 and Stonehouse, Nicola J. (2022) Higher-order structures of the foot-and-mouth disease virus RNA-dependent RNA polymerase required for genome replication. Communications Biology, 5, 61. (doi: 10.1038/s42003-021-02989-z) (PMID:35039618) (PMCID:PMC8764057)

Mahindra, A. et al. (2021) Peptides derived from the SARS-CoV-2 receptor binding motif bind to ACE2 but do not block ACE2-mediated host cell entry or pro-inflammatory cytokine induction. PLoS ONE, 16(11), e0260283. (doi: 10.1371/journal.pone.0260283) (PMID:34793553) (PMCID:PMC8601423)

Morgan, D. C. et al. (2021) Stapled ACE2 peptidomimetics designed to target the SARS-CoV-2 spike protein do not prevent virus internalisation. Peptide Science, 113(4), e24217. (doi: 10.1002/pep2.24217) (PMID:33615115) (PMCID:PMC7883042)

Sutherland, Hazel, Conley, Michaela J. ORCID logoORCID: https://orcid.org/0000-0002-3457-1149, Emmott, Edward, Streetley, James ORCID logoORCID: https://orcid.org/0000-0001-7808-605X, Goodfellow, Ian G. and Bhella, David ORCID logoORCID: https://orcid.org/0000-0003-2096-8310 (2021) The cryo-EM structure of vesivirus 2117 highlights functional variations in entry pathways for viruses in different clades of the vesivirus genus. Journal of Virology, 95(13), e0028221. (doi: 10.1128/JVI.00282-21) (PMID:33853966)

Vijayakrishnan, Swetha ORCID logoORCID: https://orcid.org/0000-0002-1895-1272, McElwee, Marion, Loney, Colin ORCID logoORCID: https://orcid.org/0000-0002-0508-1781, Rixon, Frazer and Bhella, David ORCID logoORCID: https://orcid.org/0000-0003-2096-8310 (2020) In situ structure of virus capsids within cell nuclei by correlative light and cryo-electron tomography. Scientific Reports, 10, 17596. (doi: 10.1038/s41598-020-74104-x) (PMID:33077791) (PMCID:PMC7572381)

Guzik, T. J. et al. (2020) COVID-19 and the cardiovascular system: implications for risk assessment, diagnosis, and treatment options. Cardiovascular Research, 116(10), pp. 1666-1687. (doi: 10.1093/cvr/cvaa106) (PMID:32352535) (PMCID:PMC7197627)

Bhella, David ORCID logoORCID: https://orcid.org/0000-0003-2096-8310 (2019) Cryo-electron microscopy: an introduction to the technique, and considerations when working to establish a national facility. Biophysical Reviews, 11(4), pp. 515-519. (doi: 10.1007/s12551-019-00571-w) (PMID:31359340) (PMCID:PMC6682334)

Conley, M.J. ORCID logoORCID: https://orcid.org/0000-0002-3457-1149 and Bhella, D. ORCID logoORCID: https://orcid.org/0000-0003-2096-8310 (2019) Asymmetric analysis reveals novel virus capsid features. Biophysical Reviews, 11(4), pp. 603-609. (doi: 10.1007/s12551-019-00572-9) (PMID:31342264) (PMCID:PMC6682188)

Conley, Michaela J. ORCID logoORCID: https://orcid.org/0000-0002-3457-1149, McElwee, Marion, Azmi, Liyana, Gabrielsen, Mads ORCID logoORCID: https://orcid.org/0000-0002-9848-2276, Byron, Olwyn ORCID logoORCID: https://orcid.org/0000-0001-7857-4520, Goodfellow, Ian G. and Bhella, David ORCID logoORCID: https://orcid.org/0000-0003-2096-8310 (2019) Calicivirus VP2 forms a portal-like assembly following receptor engagement. Nature, 565(7739), pp. 377-381. (doi: 10.1038/s41586-018-0852-1) (PMID:30626974)

Ho, Kok Lian, Gabrielsen, Mads, Beh, Poay Ling, Kueh, Chare Li, Qiu Xian, Thong, Streetley, James ORCID logoORCID: https://orcid.org/0000-0001-7808-605X, Tan, Wen Siang and Bhella, David ORCID logoORCID: https://orcid.org/0000-0003-2096-8310 (2018) Structure of the Macrobrachium rosenbergii nodavirus: a new genus within the Nodaviridae? PLoS Biology, 16(10), e3000038. (doi: 10.1371/journal.pbio.3000038) (PMID:30346944) (PMCID:PMC6211762)

McElwee, Marion, Vijayakrishnan, Swetha ORCID logoORCID: https://orcid.org/0000-0002-1895-1272, Rixon, Frazer and Bhella, David ORCID logoORCID: https://orcid.org/0000-0003-2096-8310 (2018) Structure of the herpes-simplex virus portal-vertex. PLoS Biology, 16(6), e2006191. (doi: 10.1371/journal.pbio.2006191) (PMID:29924793) (PMCID:PMC6028144)

Burns, Andrew M. and Bhella, David ORCID logoORCID: https://orcid.org/0000-0003-2096-8310 (2017) Killer microbes in movies. Microbiology Today, 44(4), pp. 162-165.

Barski, Michal, Brennan, Benjamin ORCID logoORCID: https://orcid.org/0000-0003-4707-726X, Miller, Ona K., Potter, Jane A., Vijayakrishnan, Swetha ORCID logoORCID: https://orcid.org/0000-0002-1895-1272, Bhella, David ORCID logoORCID: https://orcid.org/0000-0003-2096-8310, Naismith, James H., Elliott, Richard M. and Schwarz-Linek, Ulrich (2017) Rift Valley fever phlebovirus NSs protein core domain structure suggests molecular basis for nuclear filaments. eLife, 6, e29236. (doi: 10.7554/elife.29236) (PMID:28915104) (PMCID:PMC5601994)

Ho, Kok Lian, Kueh, Chare Li, Beh, Poay Ling, Tan, Wen Siang and Bhella, David ORCID logoORCID: https://orcid.org/0000-0003-2096-8310 (2017) Cryo-electron microscopy structure of the Macrobrachium rosenbergii nodavirus capsid at 7 angstroms resolution. Scientific Reports, 7, 2083. (doi: 10.1038/s41598-017-02292-0) (PMID:28522842) (PMCID:PMC5437026)

Conley, Michaela ORCID logoORCID: https://orcid.org/0000-0002-3457-1149, Emmott, Edward, Orton, Richard ORCID logoORCID: https://orcid.org/0000-0002-3389-4325, Taylor, David, Carneiro, Daniel G., Murata, Kazuyoshi, Goodfellow, Ian G., Hansman, Grant S. and Bhella, David ORCID logoORCID: https://orcid.org/0000-0003-2096-8310 (2017) Vesivirus 2117 capsids more closely resemble sapovirus and lagovirus particles than other known vesivirus structures. Journal of General Virology, 98(1), pp. 68-76. (doi: 10.1099/jgv.0.000658) (PMID:27902397) (PMCID:PMC537039)

Dadonaite, Bernadeta, Vijayakrishnan, Swetha ORCID logoORCID: https://orcid.org/0000-0002-1895-1272, Fodor, Ervin, Bhella, David ORCID logoORCID: https://orcid.org/0000-0003-2096-8310 and Hutchinson, Edward C. ORCID logoORCID: https://orcid.org/0000-0003-3673-9096 (2016) Filamentous influenza viruses. Journal of General Virology, 97(8), pp. 1755-1764. (doi: 10.1099/jgv.0.000535) (PMID:27365089)

Bhella, David ORCID logoORCID: https://orcid.org/0000-0003-2096-8310 (2015) The role of cellular adhesion molecules in virus attachment and entry. Philosophical Transactions of the Royal Society B: Biological Sciences, 370(1661), (doi: 10.1098/rstb.2014.0035) (PMID:25533093) (PMCID:PMC4275905)

Fan, Wan H., Robertson, Ashley P.E., McElwee, Marion, Bhella, David ORCID logoORCID: https://orcid.org/0000-0003-2096-8310, Rixon, Frazer J. and Lauder, Rebecca (2015) The large tegument protein pUL36 is essential for formation of the capsid vertex-specific component at the capsid-tegument interface of herpes simplex virus 1. Journal of Virology, 89(3), pp. 1502-1511. (doi: 10.1128/JVI.02887-14) (PMID:25410861) (PMCID:PMC4300765)

McGonigle, Richard, Yap, Wei Boon, Ong, Swee Tin, Gatherer, Derek, Bakker, Saskia E., Tan, Wen Siang and Bhella, David ORCID logoORCID: https://orcid.org/0000-0003-2096-8310 (2015) An N-terminal extension to the hepatitis B virus core protein forms a poorly ordered trimeric spike in assembled virus-like particles. Journal of Structural Biology, 189(2), pp. 73-80. (doi: 10.1016/j.jsb.2014.12.006) (PMID:25557498) (PMCID:PMC4318616)

Hacker, Christian, Howell, Matthew, Bhella, David ORCID logoORCID: https://orcid.org/0000-0003-2096-8310 and Lucocq, John (2014) Strategies for maximizing ATP supply in the microsporidian Encephalitozoon cuniculi: direct binding of mitochondria to the parasitophorous vacuole and clustering of the mitochondrial porin VDAC. Cellular Microbiology, 16(4), pp. 565-579. (doi: 10.1111/cmi.12240) (PMID:24245785) (PMCID:PMC4233961)

Bakker, S. E., Duquerroy, S., Galloux, M., Loney, C., Conner, E., Eleouet, J.-F., Rey, F. A. and Bhella, D. ORCID logoORCID: https://orcid.org/0000-0003-2096-8310 (2013) The respiratory syncytial virus nucleoprotein–RNA complex forms a left-handed helical nucleocapsid. Journal of General Virology, 94(8), pp. 1734-1738. (doi: 10.1099/vir.0.053025-0) (PMID:23677789) (PMCID:PMC3749527)

Rihn, S.J. ORCID logoORCID: https://orcid.org/0000-0001-9495-4056, Wilson, S.J. ORCID logoORCID: https://orcid.org/0000-0002-6065-0895, Loman, N.J., Alim, M., Bakker, S.E., Bhella, D. ORCID logoORCID: https://orcid.org/0000-0003-2096-8310, Gifford, R.J., Rixon, F.J. and Bieniasz, P.D. (2013) Extreme genetic fragility of the HIV-1 capsid. PLoS Pathogens, 9(6), e1003461. (doi: 10.1371/journal.ppat.1003461) (PMID:23818857) (PMCID:PMC3688543)

Bhella, David ORCID logoORCID: https://orcid.org/0000-0003-2096-8310 and Bakker, Saskia E. (2013) Pretty Nasty, symmetry in virus architecture. Biochemist, 35(2), pp. 14-19.

Vijayakrishnan, S. ORCID logoORCID: https://orcid.org/0000-0002-1895-1272, Loney, C. ORCID logoORCID: https://orcid.org/0000-0002-0508-1781, Jackson, D., Suphamungmee, W., Rixon, F.J. and Bhella, D. ORCID logoORCID: https://orcid.org/0000-0003-2096-8310 (2013) Cryotomography of budding influenza a virus reveals filaments with diverse morphologies that mostly do not bear a genome at their distal end. PLoS Pathogens, 9(6), e1003413. (doi: 10.1371/journal.ppat.1003413)

Schmid, Michael F., Hecksel, Corey W., Rochat, Ryan H., Bhella, David ORCID logoORCID: https://orcid.org/0000-0003-2096-8310, Chiu, Wah and Rixon, Frazer J. (2012) A tail-like assembly at the portal vertex in intact herpes simplex type-1 virions. PLoS Pathogens, 8(10), e1002961. (doi: 10.1371/journal.ppat.1002961) (PMID:23055933) (PMCID:PMC3464221)

Bhella, David ORCID logoORCID: https://orcid.org/0000-0003-2096-8310 and Goodfellow, Ian G. (2011) The cryo-electron microscopy structure of feline calicivirus bound to junctional adhesion molecule A at 9-angstrom resolution reveals receptor-induced flexibility and two distinct conformational changes in the capsid protein VP1. Journal of Virology, 85(21), pp. 11381-11390. (doi: 10.1128/JVI.05621-11) (PMID:21865392) (PMCID:PMC3194967)

Neuman, B. W. et al. (2011) A structural analysis of M protein in coronavirus assembly and morphology. Journal of Structural Biology, 174(1), pp. 11-22. (doi: 10.1016/j.jsb.2010.11.021) (PMID:21130884)

Vijayakrishnan, S. ORCID logoORCID: https://orcid.org/0000-0002-1895-1272, Kelly, S.M., Gilbert, R.J.C., Callow, P., Bhella, D. ORCID logoORCID: https://orcid.org/0000-0003-2096-8310, Forsyth, T., Lindsay, J.G. and Byron, O. (2010) Solution structure and characterisation of the human pyruvate dehydrogenase complex core assembly. Journal of Molecular Biology, 399(1), pp. 71-93. (doi: 10.1016/j.jmb.2010.03.043) (PMID:20361979) (PMCID:PMC2880790)

Parsons, J.B., Frank, S., Bhella, D. ORCID logoORCID: https://orcid.org/0000-0003-2096-8310, Liang, M., Prentice, M.B., Mulvihill, D.P. and Warren, M.J. (2010) Synthesis of empty bacterial microcompartments, directed organelle protein incorporation, and evidence of filament-associated organelle movement. Molecular Cell, 38(2), pp. 305-315. (doi: 10.1016/j.molcel.2010.04.008) (PMID:20417607)

Tawar, R.G. et al. (2009) Crystal structure of a nucleocapsid-like nucleoprotein-RNA complex of respiratory syncytial virus. Science, 326(5957), pp. 1279-1283. (doi: 10.1126/science.1177634)

Loney, C., Mottet-Osman, G., Roux, L. and Bhella, D. ORCID logoORCID: https://orcid.org/0000-0003-2096-8310 (2009) Paramyxovirus ultrastructure and genome packaging: cryo-electron tomography of Sendai virus. Journal of Virology, 83(16), pp. 8191-8197. (doi: 10.1128/JVI.00693-09)

Alba, R. et al. (2009) Identification of coagulation factor (F)X binding sites on the adenovirus serotype 5 hexon: effect of mutagenesis on FX interactions and gene transfer. Blood, 114(5), pp. 965-971. (doi: 10.1182/blood-2009-03-208835)

Greig, J.A. et al. (2009) Influence of Coagulation Factor X on In Vitro and In Vivo Gene Delivery by Adenovirus (Ad) 5, Ad35, and Chimeric Ad5/Ad35 Vectors. Molecular Therapy, 17(10), pp. 1683-1691. (doi: 10.1038/mt.2009.152)

Bhella, D. ORCID logoORCID: https://orcid.org/0000-0003-2096-8310, Gatherer, D., Chaudhry, Y., Pink, R. and Goodfellow, I.G. (2008) Structural insights into calicivirus attachment and uncoating. Journal of Virology, 82(16), pp. 8051-8058. (doi: 10.1128/JVI.00550-08)

Waddington, S. et al. (2008) Adenovirus serotype 5 hexon mediates liver gene transfer. Cell, 132(3), pp. 397-409. (doi: 10.1016/j.cell.2008.01.016)

Maclellan, K., Loney, C. ORCID logoORCID: https://orcid.org/0000-0002-0508-1781, Yeo, R.P. and Bhella, D. ORCID logoORCID: https://orcid.org/0000-0003-2096-8310 (2007) The 24-angstrom structure of respiratory syncytial virus nucleocapsid protein-RNA decameric rings. Journal of Virology, 81(17), pp. 9519-9524. (doi: 10.1128/JVI.00526-07)

Tran, T. et al. (2007) The nine C-terminal amino acids of the respiratory syncytial virus protein P are necessary and sufficient for binding to ribonucleoprotein complexes in which six ribonucleotides are contacted per N protein protomer. Journal of General Virology, 88(1), pp. 196-206. (doi: 10.1099/vir.0.82282-0)

Cao, Z., Bhella, D. ORCID logoORCID: https://orcid.org/0000-0003-2096-8310 and Lindsay, J.G. (2007) Reconstitution of the mitochondrial PrxII antioxidant defence pathway: General properties and factors affecting PrxII activity and oligomeric state. Journal of Molecular Biology, 372, pp. 1022-1033. (doi: 10.1016/j.jmb.2007.07.018)

Pettigrew, D.M., Williams, D.T., Kerrigan, D., Evans, D.J., Lea, S.M. and Bhella, D. ORCID logoORCID: https://orcid.org/0000-0003-2096-8310 (2006) Structural and functional insights into the interaction of echoviruses and decay-accelerating factor. Journal of Biological Chemistry, 281, pp. 5169-5177. (doi: 10.1074/jbc.M510362200)

Bhella, D. ORCID logoORCID: https://orcid.org/0000-0003-2096-8310, Ralph, A. and Yeo, R.P. (2004) Conformational flexibility in recombinant measles virus nucleocapsids visualised by cryo-negative stain electron microscopy and real-space helical reconstruction. Journal of Molecular Biology, 340(2), pp. 319-331. (doi: 10.1016/j.jmb.2004.05.015)

Bhella, D. ORCID logoORCID: https://orcid.org/0000-0003-2096-8310, Goodfellow, I.G., Roversi, P., Pettigrew, D., Chaudhry, Y., Evans, D.J. and Lea, S.M. (2004) The structure of echovirus type 12 bound to a two-domain fragment of its cellular attachment protein decay-accelerating factor (CD 55). Journal of Biological Chemistry, 279, pp. 8325-8332. (doi: 10.1074/jbc.M311334200)

Longhi, Sonia, Receveur-Bréchot, Véronique, Karlin, David, Johansson, Kenth, Darbon, Hervé, Bhella, David ORCID logoORCID: https://orcid.org/0000-0003-2096-8310, Yeo, Robert, Finet, Stéphanie and Canard, Bruno (2003) The C-terminal domain of the measles virus nucleoprotein is intrinsically disordered and folds upon binding to the C-terminal moiety of the phosphoprotein. Journal of Biological Chemistry, 278(20), pp. 18638-18648. (doi: 10.1074/jbc.M300518200)

Murphy, L.B., Loney, C. ORCID logoORCID: https://orcid.org/0000-0002-0508-1781, Murray, J., Bhella, D. ORCID logoORCID: https://orcid.org/0000-0003-2096-8310, Ashton, P. and Yeo, R.P. (2003) Investigations into the amino-terminal domain of the respiratory syncytial virus nucleocapsid protein reveal elements important for nucleocapsid formation and interaction with the phosphoprotein. Virology, 307(1), pp. 143-53. (doi: 10.1016/S0042-6822(02)00063-6)

Bhella, D. ORCID logoORCID: https://orcid.org/0000-0003-2096-8310, Ralph, A., Murphy, L. and Yeo, R.P. (2002) Significant differences in nucleocapsid morphology within the Paramyxoviridae. Journal of General Virology, 83(8), pp. 1831-1839.

Clayton, R.F., Owsianka, A., Aitken, J., Graham, S., Bhella, D. ORCID logoORCID: https://orcid.org/0000-0003-2096-8310 and Patel, A.H. ORCID logoORCID: https://orcid.org/0000-0003-4600-2047 (2002) Analysis of antigenicity and topology of E2 glycoprotein present on recombinant hepatitis C virus-like particles. Journal of Virology, 76(18), p. 9562. (doi: 10.1128/jvi.76.18.9562.2002)

McCLelland, D.A., Aitken, J.D., Bhella, David ORCID logoORCID: https://orcid.org/0000-0003-2096-8310, McNab, David, Mitchell, Joyce, Kelly, S.M. ORCID logoORCID: https://orcid.org/0000-0002-3516-1387, Price, N.C. and Rixon, F.J. (2002) pH reduction as a trigger for dissociation of herpes simplex virus type 1 scaffolds. Journal of Virology, 76, pp. 7407-7417. (doi: 10.1128/VJI.76.15.7407-7417.2002)

Bhella, D. ORCID logoORCID: https://orcid.org/0000-0003-2096-8310, Rixon, F.J. and Dargan, D.J. (2000) Cryomicroscopy of human cytomegalovirus virions reveals more densely packed genomic DNA than in herpes simplex virus type 1. Journal of Molecular Biology, 295(2), pp. 155-161. (doi: 10.1006/jmbi.1999.3344)

AL-Khayat, H.A, Bhella, D. ORCID logoORCID: https://orcid.org/0000-0003-2096-8310, Kenney, J.M, Roth, J.F, Kingsman, A.J, Martin-Rendon, E. and Saibil, H.R (1999) Yeast Ty retrotransposons assemble into virus-like particles whose T-numbers depend on the C-terminal length of the capsid protein. Journal of Molecular Biology, 292(1), pp. 65-73. (doi: 10.1006/jmbi.1999.3055)

Book Sections

Bhella, D. ORCID logoORCID: https://orcid.org/0000-0003-2096-8310 (2007) Measles virus nucleocapsid structure, conformational flexibility and the rule of six. In: Longhi, S. (ed.) Measles Virus Nucleoprotein. Series: Intrinsically disordered proteins. Nova Publishers, pp. 37-50. ISBN 9781606925218

Davidson, A.J. and Bhella, D. ORCID logoORCID: https://orcid.org/0000-0003-2096-8310 (2007) Comparative genome and virion structure. In: Arvin, A., Campadelli-Fiume, G. and Mocarski, E. (eds.) Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis. Cambridge University Press. ISBN 9780521827140

This list was generated on Sun Jun 15 09:59:55 2025 BST.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Accelerating throughput at Scotland's national Cryo-EM centre - a next generation direct electron detector for SCMI.
    Medical Research Council
    2022 - 2023
     
  • Molecular basis for Rift Valley fever phlebovirus NSs protein function
    Medical Research Council
    2022 - 2025
     
  • Host and viral factors in the emergence of a virulent strain of calicivirus
    Biotechnology and Biological Sciences Research Council
    2020 - 2022
     
  • CryoEM - SULSA
    Scottish Universities Life Sciences Alliance
    2018 - 2022
     
  • SMIC-SULSA
    Scottish Funding Council
    2018 - 2021
     
  • The Scottish Macromolecular Imaging Centre (SMIC)
    Medical Research Council
    2017 - 2022
     
  • SCMI - CryoEM - St Andrews
    University of St Andrews
    2017 - 2022
     
  • SCMI - CryoEM - University of Dundee
    University of Dundee
    2017 - 2022
     
  • SCMI - CryoEM - University of Edinburgh
    University of Edinburgh
    2017 - 2022
     
  • Quinquennial Core Funds
    Medical Research Council
    2016 - 2021
     
  • Characterisation of Zika virus neutralisation and virion structure by cryogenic electron microscopy and 3D reconstruction.
    Medical Research Council
    2016 - 2017
     
  • A structure analysis of the intact virion and replicative complexes of human respiratory syncytial virus
    Medical Research Council
    2014 - 2019
     
  • Initiation and regulation of RSV mRNA transcription and genome replication
    National Institute of Allergy and Infectious Diseases
    2014 - 2018
     
  • Structural studies of human viruses and host interactions
    Medical Research Council
    2013 - 2016
     

Research datasets

Jump to: 2021
Number of items: 2.

2021

Syme, C. , Bhella, D. and Hutchinson, E. (2021) A global map of the Zika virus phosphoproteome reveals host-driven regulation of viral budding. [Data Collection]

Goldfarb, D. M., Piras, I., Bone, J., Amat, J., Parrish, C., Bhella, D. , Hutchinson, E. and Murcia, P. (2021) Identification of previously unknown genetic determinants of influenza A virus morphology. [Data Collection]

This list was generated on Sun Jun 15 04:20:52 2025 BST.

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