Dr Adam Fletcher

  • Research Fellow: UKRI Future Leadership Fellow (Virology)

telephone: 01413304557
email: Adam.Fletcher@glasgow.ac.uk
pronouns: He/him/his

Import to contacts

ORCID iDhttps://orcid.org/0000-0003-1742-6588

Publications

List by: Type | Date

Jump to: 2025 | 2021 | 2020 | 2019 | 2018 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2008
Number of items: 19.

2025

Ahel, J. et al. (2025) ATP functions as a pathogen-associated molecular pattern to activate the E3 ubiquitin ligase RNF213. Nature Communications, 16(1), 4414. (doi: 10.1038/s41467-025-59444-4) (PMID:40360510) (PMCID:PMC12075652)

2021

De Cesare, Virginia, Carbajo Lopez, Daniel, Mabbitt, Peter D., Fletcher, Adam J. ORCID logoORCID: https://orcid.org/0000-0003-1742-6588, Soetens, Mathieu, Antico, Odetta, Wood, Nicola T. and Virdee, Satpal (2021) Deubiquitinating enzyme amino acid profiling reveals a class of ubiquitin esterases. Proceedings of the National Academy of Sciences, 118(4), e200694711. (doi: 10.1073/pnas.2006947118) (PMID:33479176) (PMCID:PMC7848729)

2020

Mabbitt, Peter D., Loreto, Andrea, Déry, Marc-André, Fletcher, Adam J. ORCID logoORCID: https://orcid.org/0000-0003-1742-6588, Stanley, Mathew, Pao, Kuan-Chuan, Wood, Nicola T., Coleman, Michael P. and Virdee, Satpal (2020) Structural basis for RING-Cys-Relay E3 ligase activity and its role in axon integrity. Nature Chemical Biology, 16(11), pp. 1227-1236. (doi: 10.1038/s41589-020-0598-6) (PMID:32747811) (PMCID:PMC7610530)

2019

Mallery, D. L. et al. (2019) Cellular IP6 levels limit HIV production while viruses that cannot efficiently package IP6 are attenuated for infection and replication. Cell Reports, 29(12), 3983-3996.e4. (doi: 10.1016/j.celrep.2019.11.050) (PMID:31851928) (PMCID:PMC6931105)

Mathur, Sunil, Fletcher, Adam J. ORCID logoORCID: https://orcid.org/0000-0003-1742-6588, Branigan, Emma, Hay, Ronald T. and Virdee, Satpal (2019) Photocrosslinking activity-based probes for ubiquitin RING E3 ligases. Cell Chemical Biology, 27(1), 74-82.e6. (doi: 10.1016/j.chembiol.2019.11.013) (PMID:31859248) (PMCID:PMC6963778)

2018

Fletcher, Adam J. ORCID logoORCID: https://orcid.org/0000-0003-1742-6588, Vaysburd, Marina, Maslen, Sarah, Zeng, Jingwei, Skehel, J. Mark, Towers, Greg J. and James, Leo C. (2018) Trivalent RING assembly on retroviral capsids activates TRIM5 ubiquitination and innate immune signaling. Cell Host and Microbe, 24(6), 761-775.e6. (doi: 10.1016/j.chom.2018.10.007) (PMID:30503508) (PMCID:PMC6299210)

Dickson, C. et al. (2018) Intracellular antibody signalling is regulated by phosphorylation of the Fc receptor TRIM21. eLife, 7, e32660. (doi: 10.7554/eLife.32660) (PMID:29667579) (PMCID:PMC5906095)

2016

Fletcher, Adam J. ORCID logoORCID: https://orcid.org/0000-0003-1742-6588, James, Leo C. and Tsai, B. (2016) Coordinated neutralization and immune activation by the cytosolic antibody receptor TRIM21. Journal of Virology, 90(10), pp. 4856-4859. (doi: 10.1128/JVI.00050-16) (PMID:26937031) (PMCID:PMC4859718)

2015

Fletcher, Adam J. ORCID logoORCID: https://orcid.org/0000-0003-1742-6588, Mallery, Donna L., Watkinson, Ruth E., Dickson, Claire F. and James, Leo C. (2015) Sequential ubiquitination and deubiquitination enzymes synchronize the dual sensor and effector functions of TRIM21. Proceedings of the National Academy of Sciences, 112(32), pp. 10014-10019. (doi: 10.1073/pnas.1507534112) (PMID:26150489) (PMCID:PMC4538650)

Fletcher, Adam J. ORCID logoORCID: https://orcid.org/0000-0003-1742-6588, Christensen, Devin E., Nelson, Chad, Tan, Choon Ping, Schaller, Torsten, Lehner, Paul J., Sundquist, Wesley I. and Towers, Greg J. (2015) TRIM 5α requires Ube2W to anchor Lys63‐linked ubiquitin chains and restrict reverse transcription. EMBO Journal, 34(15), pp. 2078-2095. (doi: 10.15252/embj.201490361) (PMID:26101372) (PMCID:PMC4551353)

2014

Guiliano, D. B. et al. (2014) Endoplasmic reticulum degradation-enhancing α-mannosidase-like protein 1 targets misfolded HLA-B27 dimers for endoplasmic reticulum-associated degradation. Arthritis and Rheumatology, 66(11), pp. 2976-2988. (doi: 10.1002/art.38809) (PMID:25132672) (PMCID:PMC4399817)

Cullen, Bryan R., Price, Amanda J., Jacques, David A., McEwan, William A., Fletcher, Adam J. ORCID logoORCID: https://orcid.org/0000-0003-1742-6588, Essig, Sebastian, Chin, Jason W., Halambage, Upul D., Aiken, Christopher and James, Leo C. (2014) Host cofactors and pharmacologic ligands share an essential interface in HIV-1 capsid that is lost upon disassembly. PLoS Pathogens, 10(10), e1004459. (doi: 10.1371/journal.ppat.1004459) (PMID:25356722) (PMCID:PMC4214760)

2013

Rasaiyaah, J. et al. (2013) HIV-1 evades innate immune recognition through specific cofactor recruitment. Nature, 503(7476), pp. 402-405. (doi: 10.1038/nature12769) (PMID:24196705) (PMCID:PMC3928559)

Fletcher, Adam J. ORCID logoORCID: https://orcid.org/0000-0003-1742-6588 and Towers, Greg J. (2013) Inhibition of retroviral replication by members of the TRIM protein family. In: Cullen, B. (ed.) Intrinsic Immunity. Series: Current topics in microbiology and immunology (371). Springer, pp. 29-66. ISBN 9783642377655 (doi: 10.1007/978-3-642-37765-5_2)

2012

Krausslich, Hans-Georg, Price, Amanda J., Fletcher, Adam J. ORCID logoORCID: https://orcid.org/0000-0003-1742-6588, Schaller, Torsten, Elliott, Tom, Lee, KyeongEun, KewalRamani, Vineet N., Chin, Jason W., Towers, Greg J. and James, Leo C. (2012) CPSF6 defines a conserved capsid interface that modulates HIV-1 replication. PLoS Pathogens, 8(8), e1002896. (doi: 10.1371/journal.ppat.1002896) (PMID:22956906) (PMCID:PMC3431306)

2011

Aiken, C. et al. (2011) HIV-1 capsid-cyclophilin interactions determine nuclear import pathway, integration targeting and replication efficiency. PLoS Pathogens, 7(12), e1002439. (doi: 10.1371/journal.ppat.1002439) (PMID:22174692) (PMCID:PMC3234246)

2010

Fletcher, Adam J. ORCID logoORCID: https://orcid.org/0000-0003-1742-6588, Hué, Stéphane, Schaller, Torsten, Pillay, Deenan and Towers, Greg J. (2010) Hare TRIM5α restricts divergent retroviruses and exhibits significant sequence variation from closely related Lagomorpha TRIM5 genes. Journal of Virology, 84(23), pp. 12463-12468. (doi: 10.1128/jvi.01514-10) (PMID:20861252) (PMCID:PMC2976397)

Ylinen, Laura M. J., Schaller, Torsten, Price, Amanda, Fletcher, Adam J. ORCID logoORCID: https://orcid.org/0000-0003-1742-6588, Noursadeghi, Mahdad, James, Leo C. and Towers, Greg J. (2010) Cyclophilin A levels dictate infection efficiency of human immunodeficiency virus type 1 capsid escape mutants A92E and G94D. Journal of Virology, 83(4), pp. 2044-2047. (doi: 10.1128/jvi.01876-08) (PMID:19073742) (PMCID:PMC2643744)

2008

Lyulcheva, Ekaterina, Taylor, Eleanor, Michael, Magdalene, Vehlow, Anne, Tan, Shengjiang, Fletcher, Adam ORCID logoORCID: https://orcid.org/0000-0003-1742-6588, Krause, Matthias and Bennett, Daimark (2008) Drosophila pico and its mammalian ortholog lamellipodin activate serum response factor and promote cell proliferation. Developmental Cell, 15(5), pp. 680-690. (doi: 10.1016/j.devcel.2008.09.020) (PMID:19000833) (PMCID:PMC2691947)

This list was generated on Sat Jun 14 21:06:12 2025 BST.
Jump to: Articles | Book Sections
Number of items: 19.

Articles

Ahel, J. et al. (2025) ATP functions as a pathogen-associated molecular pattern to activate the E3 ubiquitin ligase RNF213. Nature Communications, 16(1), 4414. (doi: 10.1038/s41467-025-59444-4) (PMID:40360510) (PMCID:PMC12075652)

De Cesare, Virginia, Carbajo Lopez, Daniel, Mabbitt, Peter D., Fletcher, Adam J. ORCID logoORCID: https://orcid.org/0000-0003-1742-6588, Soetens, Mathieu, Antico, Odetta, Wood, Nicola T. and Virdee, Satpal (2021) Deubiquitinating enzyme amino acid profiling reveals a class of ubiquitin esterases. Proceedings of the National Academy of Sciences, 118(4), e200694711. (doi: 10.1073/pnas.2006947118) (PMID:33479176) (PMCID:PMC7848729)

Mabbitt, Peter D., Loreto, Andrea, Déry, Marc-André, Fletcher, Adam J. ORCID logoORCID: https://orcid.org/0000-0003-1742-6588, Stanley, Mathew, Pao, Kuan-Chuan, Wood, Nicola T., Coleman, Michael P. and Virdee, Satpal (2020) Structural basis for RING-Cys-Relay E3 ligase activity and its role in axon integrity. Nature Chemical Biology, 16(11), pp. 1227-1236. (doi: 10.1038/s41589-020-0598-6) (PMID:32747811) (PMCID:PMC7610530)

Mallery, D. L. et al. (2019) Cellular IP6 levels limit HIV production while viruses that cannot efficiently package IP6 are attenuated for infection and replication. Cell Reports, 29(12), 3983-3996.e4. (doi: 10.1016/j.celrep.2019.11.050) (PMID:31851928) (PMCID:PMC6931105)

Mathur, Sunil, Fletcher, Adam J. ORCID logoORCID: https://orcid.org/0000-0003-1742-6588, Branigan, Emma, Hay, Ronald T. and Virdee, Satpal (2019) Photocrosslinking activity-based probes for ubiquitin RING E3 ligases. Cell Chemical Biology, 27(1), 74-82.e6. (doi: 10.1016/j.chembiol.2019.11.013) (PMID:31859248) (PMCID:PMC6963778)

Fletcher, Adam J. ORCID logoORCID: https://orcid.org/0000-0003-1742-6588, Vaysburd, Marina, Maslen, Sarah, Zeng, Jingwei, Skehel, J. Mark, Towers, Greg J. and James, Leo C. (2018) Trivalent RING assembly on retroviral capsids activates TRIM5 ubiquitination and innate immune signaling. Cell Host and Microbe, 24(6), 761-775.e6. (doi: 10.1016/j.chom.2018.10.007) (PMID:30503508) (PMCID:PMC6299210)

Dickson, C. et al. (2018) Intracellular antibody signalling is regulated by phosphorylation of the Fc receptor TRIM21. eLife, 7, e32660. (doi: 10.7554/eLife.32660) (PMID:29667579) (PMCID:PMC5906095)

Fletcher, Adam J. ORCID logoORCID: https://orcid.org/0000-0003-1742-6588, James, Leo C. and Tsai, B. (2016) Coordinated neutralization and immune activation by the cytosolic antibody receptor TRIM21. Journal of Virology, 90(10), pp. 4856-4859. (doi: 10.1128/JVI.00050-16) (PMID:26937031) (PMCID:PMC4859718)

Fletcher, Adam J. ORCID logoORCID: https://orcid.org/0000-0003-1742-6588, Mallery, Donna L., Watkinson, Ruth E., Dickson, Claire F. and James, Leo C. (2015) Sequential ubiquitination and deubiquitination enzymes synchronize the dual sensor and effector functions of TRIM21. Proceedings of the National Academy of Sciences, 112(32), pp. 10014-10019. (doi: 10.1073/pnas.1507534112) (PMID:26150489) (PMCID:PMC4538650)

Fletcher, Adam J. ORCID logoORCID: https://orcid.org/0000-0003-1742-6588, Christensen, Devin E., Nelson, Chad, Tan, Choon Ping, Schaller, Torsten, Lehner, Paul J., Sundquist, Wesley I. and Towers, Greg J. (2015) TRIM 5α requires Ube2W to anchor Lys63‐linked ubiquitin chains and restrict reverse transcription. EMBO Journal, 34(15), pp. 2078-2095. (doi: 10.15252/embj.201490361) (PMID:26101372) (PMCID:PMC4551353)

Guiliano, D. B. et al. (2014) Endoplasmic reticulum degradation-enhancing α-mannosidase-like protein 1 targets misfolded HLA-B27 dimers for endoplasmic reticulum-associated degradation. Arthritis and Rheumatology, 66(11), pp. 2976-2988. (doi: 10.1002/art.38809) (PMID:25132672) (PMCID:PMC4399817)

Cullen, Bryan R., Price, Amanda J., Jacques, David A., McEwan, William A., Fletcher, Adam J. ORCID logoORCID: https://orcid.org/0000-0003-1742-6588, Essig, Sebastian, Chin, Jason W., Halambage, Upul D., Aiken, Christopher and James, Leo C. (2014) Host cofactors and pharmacologic ligands share an essential interface in HIV-1 capsid that is lost upon disassembly. PLoS Pathogens, 10(10), e1004459. (doi: 10.1371/journal.ppat.1004459) (PMID:25356722) (PMCID:PMC4214760)

Rasaiyaah, J. et al. (2013) HIV-1 evades innate immune recognition through specific cofactor recruitment. Nature, 503(7476), pp. 402-405. (doi: 10.1038/nature12769) (PMID:24196705) (PMCID:PMC3928559)

Krausslich, Hans-Georg, Price, Amanda J., Fletcher, Adam J. ORCID logoORCID: https://orcid.org/0000-0003-1742-6588, Schaller, Torsten, Elliott, Tom, Lee, KyeongEun, KewalRamani, Vineet N., Chin, Jason W., Towers, Greg J. and James, Leo C. (2012) CPSF6 defines a conserved capsid interface that modulates HIV-1 replication. PLoS Pathogens, 8(8), e1002896. (doi: 10.1371/journal.ppat.1002896) (PMID:22956906) (PMCID:PMC3431306)

Aiken, C. et al. (2011) HIV-1 capsid-cyclophilin interactions determine nuclear import pathway, integration targeting and replication efficiency. PLoS Pathogens, 7(12), e1002439. (doi: 10.1371/journal.ppat.1002439) (PMID:22174692) (PMCID:PMC3234246)

Fletcher, Adam J. ORCID logoORCID: https://orcid.org/0000-0003-1742-6588, Hué, Stéphane, Schaller, Torsten, Pillay, Deenan and Towers, Greg J. (2010) Hare TRIM5α restricts divergent retroviruses and exhibits significant sequence variation from closely related Lagomorpha TRIM5 genes. Journal of Virology, 84(23), pp. 12463-12468. (doi: 10.1128/jvi.01514-10) (PMID:20861252) (PMCID:PMC2976397)

Ylinen, Laura M. J., Schaller, Torsten, Price, Amanda, Fletcher, Adam J. ORCID logoORCID: https://orcid.org/0000-0003-1742-6588, Noursadeghi, Mahdad, James, Leo C. and Towers, Greg J. (2010) Cyclophilin A levels dictate infection efficiency of human immunodeficiency virus type 1 capsid escape mutants A92E and G94D. Journal of Virology, 83(4), pp. 2044-2047. (doi: 10.1128/jvi.01876-08) (PMID:19073742) (PMCID:PMC2643744)

Lyulcheva, Ekaterina, Taylor, Eleanor, Michael, Magdalene, Vehlow, Anne, Tan, Shengjiang, Fletcher, Adam ORCID logoORCID: https://orcid.org/0000-0003-1742-6588, Krause, Matthias and Bennett, Daimark (2008) Drosophila pico and its mammalian ortholog lamellipodin activate serum response factor and promote cell proliferation. Developmental Cell, 15(5), pp. 680-690. (doi: 10.1016/j.devcel.2008.09.020) (PMID:19000833) (PMCID:PMC2691947)

Book Sections

Fletcher, Adam J. ORCID logoORCID: https://orcid.org/0000-0003-1742-6588 and Towers, Greg J. (2013) Inhibition of retroviral replication by members of the TRIM protein family. In: Cullen, B. (ed.) Intrinsic Immunity. Series: Current topics in microbiology and immunology (371). Springer, pp. 29-66. ISBN 9783642377655 (doi: 10.1007/978-3-642-37765-5_2)

This list was generated on Sat Jun 14 21:06:12 2025 BST.

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