Dr Peter Childs
- Affiliate (School of Molecular Biosciences)
email:
Peter.Childs@glasgow.ac.uk
Room 722, Rankine Building, Biomedical Division, School of Engineering
Publications
2024
Dhawan, U. , Williams, J. A., Windmill, J. F.C., Childs, P., Gonzalez-Garcia, C., Dalby, M. J. and Salmeron-Sanchez, M. (2024) Engineered surfaces that promote capture of latent proteins to facilitate integrin-mediated mechanical activation of growth factors. Advanced Materials, (doi: 10.1002/adma.202310789) (PMID:38253339) (Early Online Publication)
2023
Romero-Torrecilla, J. A. et al. (2023) An engineered periosteum for efficient delivery of rhBMP-2 and mesenchymal progenitor cells during bone regeneration. npj Regenerative Medicine, 8, 54. (doi: 10.1038/s41536-023-00330-2) (PMID:37773177) (PMCID:PMC10541910)
Donnelly, H., Sprott, M. R. , Poudel, A., Campsie, P., Childs, P., Reid, S., Salmeron-Sanchez, M. and Biggs, M. (2023) Surface modified piezoelectric co-polymer poly (vinylidene fluoride-trifluoroethylene) supports physiological extracellular matrices to enhance mesenchymal stem cell adhesion for nanoscale mechanical stimulation. ACS Applied Materials and Interfaces, 15(44), pp. 50652-50662. (doi: 10.1021/acsami.3c05128) (PMID:37718477) (PMCID:PMC10636716)
Marshall, W. G. et al. (2023) Bioengineering an osteoinductive treatment for bone healing disorders: a small animal case series. VCOT Open, 6(1), e41-e51. (doi: 10.1055/s-0043-1762900)
2022
Damiati, L. A. et al. (2022) Materials-driven fibronectin assembly on nanoscale topography enhances mesenchymal stem cell adhesion, protecting cells from bacterial virulence factors and preventing biofilm formation. Biomaterials, 280, 121263. (doi: 10.1016/j.biomaterials.2021.121263) (PMID:34810036)
2021
Hodgkinson, T. et al. (2021) The use of nanovibration to discover specific and potent bioactive metabolites that stimulate osteogenic differentiation in mesenchymal stem cells. Science Advances, 7(9), eabb7921. (doi: 10.1126/sciadv.abb7921) (PMID:33637520) (PMCID:PMC7909882)
2020
Childs, P. G., Reid, S., Salmeron-Sanchez, M. and Dalby, M. J. (2020) Hurdles to uptake of mesenchymal stem cells and their progenitors in therapeutic products. Biochemical Journal, 477(17), pp. 3349-3366. (doi: 10.1042/BCJ20190382) (PMID:32941644) (PMCID:PMC7505558)
Orapiriyakul, W. et al. (2020) Nanovibrational stimulation of mesenchymal stem cells induces therapeutic reactive oxygen species and inflammation for 3D bone tissue engineering. ACS Nano, 14(8), pp. 10027-10044. (doi: 10.1021/acsnano.0c03130) (PMID:32658450) (PMCID:PMC7458485)
Alba, A., Jayawarna, V., Childs, P. G., Dalby, M. J. and Salmeron-Sanchez, M. (2020) Plasma polymerised nanoscale coatings of controlled thickness for efficient solid-phase presentation of growth factors. Materials Science and Engineering C: Materials for Biological Applications, 113, 110966. (doi: 10.1016/j.msec.2020.110966) (PMID:32487385)
Robertson, S., Childs, P. G., Akinbobola, A., Henriquez, F. L., Ramage, G. , Reid, S., Mackay, W. G. and Williams, C. (2020) Reduction of Pseudomonas aeruginosa biofilm formation through the application of nanoscale vibration. Journal of Bioscience and Bioengineering, 129(3), pp. 379-386. (doi: 10.1016/j.jbiosc.2019.09.003) (PMID:31623950)
2019
Campsie, P., Childs, P. G., Robertson, S. N., Cameron, K., Hough, J. , Salmeron-Sanchez, M. , Tsimbouri, P. M., Vichare, P., Dalby, M. J. and Reid, S. (2019) Design, construction and characterisation of a novel nanovibrational bioreactor and cultureware for osteogenesis. Scientific Reports, 9, 12944. (doi: 10.1038/s41598-019-49422-4) (PMID:31506561) (PMCID:PMC6736847)
Cheng, Z. A. et al. (2019) Nanoscale coatings for ultralow dose BMP‐2‐driven regeneration of critical‐sized bone defects. Advanced Science, 6(2), 1800361. (doi: 10.1002/advs.201800361) (PMID:30693176) (PMCID:PMC6343071)
2018
Robertson, S. N. et al. (2018) Control of cell behaviour through nanovibrational stimulation: nanokicking. Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 376(2120), 20170290. (doi: 10.1098/rsta.2017.0290) (PMID:29661978) (PMCID:PMC5915650)
2017
Tsimbouri, P. M. et al. (2017) Stimulation of 3D osteogenesis by mesenchymal stem cells using a nanovibrational bioreactor. Nature Biomedical Engineering, 1, pp. 758-770. (doi: 10.1038/s41551-017-0127-4) (PMID:31015671)
2015
Pemberton, G. D., Childs, P., Reid, S., Nikukar, H., Tsimbouri, M. , Gadegaard, N. , Curtis, A. S. and Dalby, M. J. (2015) Nanoscale stimulation of osteoblastogenesis from mesenchymal stem cells: nanotopography and nanokicking. Nanomedicine, 10(4), pp. 547-560. (doi: 10.2217/nnm.14.134) (PMID:25723089)
Articles
Dhawan, U. , Williams, J. A., Windmill, J. F.C., Childs, P., Gonzalez-Garcia, C., Dalby, M. J. and Salmeron-Sanchez, M. (2024) Engineered surfaces that promote capture of latent proteins to facilitate integrin-mediated mechanical activation of growth factors. Advanced Materials, (doi: 10.1002/adma.202310789) (PMID:38253339) (Early Online Publication)
Romero-Torrecilla, J. A. et al. (2023) An engineered periosteum for efficient delivery of rhBMP-2 and mesenchymal progenitor cells during bone regeneration. npj Regenerative Medicine, 8, 54. (doi: 10.1038/s41536-023-00330-2) (PMID:37773177) (PMCID:PMC10541910)
Donnelly, H., Sprott, M. R. , Poudel, A., Campsie, P., Childs, P., Reid, S., Salmeron-Sanchez, M. and Biggs, M. (2023) Surface modified piezoelectric co-polymer poly (vinylidene fluoride-trifluoroethylene) supports physiological extracellular matrices to enhance mesenchymal stem cell adhesion for nanoscale mechanical stimulation. ACS Applied Materials and Interfaces, 15(44), pp. 50652-50662. (doi: 10.1021/acsami.3c05128) (PMID:37718477) (PMCID:PMC10636716)
Marshall, W. G. et al. (2023) Bioengineering an osteoinductive treatment for bone healing disorders: a small animal case series. VCOT Open, 6(1), e41-e51. (doi: 10.1055/s-0043-1762900)
Damiati, L. A. et al. (2022) Materials-driven fibronectin assembly on nanoscale topography enhances mesenchymal stem cell adhesion, protecting cells from bacterial virulence factors and preventing biofilm formation. Biomaterials, 280, 121263. (doi: 10.1016/j.biomaterials.2021.121263) (PMID:34810036)
Hodgkinson, T. et al. (2021) The use of nanovibration to discover specific and potent bioactive metabolites that stimulate osteogenic differentiation in mesenchymal stem cells. Science Advances, 7(9), eabb7921. (doi: 10.1126/sciadv.abb7921) (PMID:33637520) (PMCID:PMC7909882)
Childs, P. G., Reid, S., Salmeron-Sanchez, M. and Dalby, M. J. (2020) Hurdles to uptake of mesenchymal stem cells and their progenitors in therapeutic products. Biochemical Journal, 477(17), pp. 3349-3366. (doi: 10.1042/BCJ20190382) (PMID:32941644) (PMCID:PMC7505558)
Orapiriyakul, W. et al. (2020) Nanovibrational stimulation of mesenchymal stem cells induces therapeutic reactive oxygen species and inflammation for 3D bone tissue engineering. ACS Nano, 14(8), pp. 10027-10044. (doi: 10.1021/acsnano.0c03130) (PMID:32658450) (PMCID:PMC7458485)
Alba, A., Jayawarna, V., Childs, P. G., Dalby, M. J. and Salmeron-Sanchez, M. (2020) Plasma polymerised nanoscale coatings of controlled thickness for efficient solid-phase presentation of growth factors. Materials Science and Engineering C: Materials for Biological Applications, 113, 110966. (doi: 10.1016/j.msec.2020.110966) (PMID:32487385)
Robertson, S., Childs, P. G., Akinbobola, A., Henriquez, F. L., Ramage, G. , Reid, S., Mackay, W. G. and Williams, C. (2020) Reduction of Pseudomonas aeruginosa biofilm formation through the application of nanoscale vibration. Journal of Bioscience and Bioengineering, 129(3), pp. 379-386. (doi: 10.1016/j.jbiosc.2019.09.003) (PMID:31623950)
Campsie, P., Childs, P. G., Robertson, S. N., Cameron, K., Hough, J. , Salmeron-Sanchez, M. , Tsimbouri, P. M., Vichare, P., Dalby, M. J. and Reid, S. (2019) Design, construction and characterisation of a novel nanovibrational bioreactor and cultureware for osteogenesis. Scientific Reports, 9, 12944. (doi: 10.1038/s41598-019-49422-4) (PMID:31506561) (PMCID:PMC6736847)
Cheng, Z. A. et al. (2019) Nanoscale coatings for ultralow dose BMP‐2‐driven regeneration of critical‐sized bone defects. Advanced Science, 6(2), 1800361. (doi: 10.1002/advs.201800361) (PMID:30693176) (PMCID:PMC6343071)
Robertson, S. N. et al. (2018) Control of cell behaviour through nanovibrational stimulation: nanokicking. Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 376(2120), 20170290. (doi: 10.1098/rsta.2017.0290) (PMID:29661978) (PMCID:PMC5915650)
Tsimbouri, P. M. et al. (2017) Stimulation of 3D osteogenesis by mesenchymal stem cells using a nanovibrational bioreactor. Nature Biomedical Engineering, 1, pp. 758-770. (doi: 10.1038/s41551-017-0127-4) (PMID:31015671)
Pemberton, G. D., Childs, P., Reid, S., Nikukar, H., Tsimbouri, M. , Gadegaard, N. , Curtis, A. S. and Dalby, M. J. (2015) Nanoscale stimulation of osteoblastogenesis from mesenchymal stem cells: nanotopography and nanokicking. Nanomedicine, 10(4), pp. 547-560. (doi: 10.2217/nnm.14.134) (PMID:25723089)
Research datasets
2020
Orapiriyakul, W., Tsimbouri, M. , Childs, P., Campsie, P., Wells, J., Fernandez-Yague, M. A., Burgess, K., Tanner, E., Tassieri, M. , Meek, D., Vassalli, M. , Biggs, M. J.P., Salmeron-Sanchez, M. , Oreffo, R. O. C., Reid, S. and Dalby, M. (2020) Nanovibrational Stimulation of Mesenchymal Stem Cells Induces Therapeutic Reactive Oxygen Species and Inflammation for Three- Dimensional Bone Tissue Engineering. [Data Collection]
Hodgkinson, T., Tsimbouri, M. , Llopis-Hernandez, V. , Campsie, P., Scurr, D., Childs, P., Phillips, D. , Donnelly, S., Wells, J., Salmeron-Sanchez, M. , Burgess, K., Alexander, M., Vassalli, M. , Oreffo, R., Reid, S., France, D. and Dalby, M. (2020) Nanovibrational mesenchymal stem cell stimulation allows detection of highly osteo-specific bioactive metabolites that can be modified for enhanced potency. [Data Collection]
2017
Tsimbouri, P. , Childs, P., Pemberton, G. D., Yang, J., Jayawarna, V., Orapiriyakul, W., Burgess, K., Gonzalez-Garcia, C., Blackburn, G., Thomas, D., Giraldo, C. V., Biggs, M. J. P., Curtis, A., Salmerón-Sanchez, M., Reid, S. and Dalby, M. (2017) Stimulation of 3D osteogenesis by mesenchymal stem cells via a nanovibrational bioreactor. [Data Collection]