Dr William McLean

  • Senior Clinical University Lecturer in Restorative Dentistry (Dental School)

telephone: 0141 211 9626
email: William.McLean@glasgow.ac.uk

Biography

William McLean graduated from the University of Wales College of Medicine Dental School in 1997. During his undergraduate years, he intercalated and was awarded a Bachelor of Science (Hons) Degree in Dental Science. Following graduation, he was awarded an Action Research Training Fellowship to pursue his PhD. The following four years were spent at Harvard Medical School Department of Cell Biology investigating craniofacial and skeletal development. In 2002, he took up a position as a lecturer at Manchester University in the School of Biological Sciences. In 2004, he returned to clinical practice and subsequently undertook postgraduate training in Endodontology.

He now divides him time between Endodontic referral practice and academic practice. He is the Academic Lead for Undergraduate Endodontics at the University of Glasgow Dental School, programme co-ordinator for the MSc Endodontics and lead for the Glasgow Endodontology Group. He currently is treasurer of the British Endodontic Society and a Dental School Tutor for the Royal College of Physicians and Surgeons of Glasgow.


Research interests

Glasgow Endodontology Group

The Glasgow Endodontology Group (GEG) is a multidisciplinary group working on the immunopathobiology and microbiology of endodontic disease towards the development of novel strategies in its clinical management. The group consists of bioengineers, microbiologists, biologists and clinicians.

The overall aim of the group is to develop strategies to manage endodontic disease using regenerative procedures.

Overarching Theme

Race for the Space - interaction between cells, surfaces and therapeutics in endodontic regeneration

Endodontic disease, an infection of the root canal space is a significant cause of dental morbidity worldwide. Endodontic infections can result from dental trauma, carious lesions, non-carious tooth surface loss or on rare occasions from periodontal infection progressing to the root apex. This condition, in which complex biofilms form within the intricate anatomy of the root canal system is treated by mechanical debridement, chemical disinfection and subsequently obturation of the space in a process termed root canal treatment. One million root canal treatments are performed under the National Health Service each year, costing £50.5 million. Outcomes vary considerably for the established treatments.  It is clear that although allowing patients to retain teeth, it is far from ideal, and despite many “advances” in clinical endodontics we have seen little improvement in outcomes. It has been proposed that the ideal outcome for endodontic therapy would be to establish, through regenerative endodontics, a healthy pulp within the cleansed and disinfected root canal system.

interaction between cells, surfaces and therapeutics in endodontic regeneration

‌ 

Research Streams

  1. Understanding endodontic biofilms, inter-kingdom relationships within them, and managing them to prepare for regeneration
  2. Inflammation in regeneration
  3. Orchestrating cellular invasion and organisation in regeneration

Group Members/Collaborators

  • Dr Will McLean – Senior Clinical Lecturer in Restorative Dentistry (Dental School)
  • Professor Gordon Ramage – Professor of Microbiology (Dental School)
  • Dr Chris Nile - Senior Lecturer in Oral Biosciences (Dental School)
  • Professor Matthew Dalby - Professor of Cell Engineering (Institute of Molecular Cell and Systems Biology)

Students

  • Khawlah Albashaireh – PhD Student
  • Om-Alkhir Shanta – PhD Student
  • Suror Shaban – MSc Student
  • Ashwin Mallya – MSc Student
  • Neha Verma – MSc Student

Twitter

Glasgow Endodontology Group:  @GlasgowEndo

Will McLean: @McLeanDr


Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Do interkingdom polymicrobial biofilms impede the treatment of apical periodontitis?
    British Endodontic Society
    2018 - 2020
     

Publications

List by: Type | Date

Jump to: 2018 | 2009 | 2008 | 2004 | 2002 | 2001 | 2000 | 1997 | 1995 | 1994
Number of items: 18.

2018

Abusrewil, S. M., McLean, W. and Scott, J. A. (2018) The use of Bioceramics as root-end filling materials in periradicular surgery: a literature review. Saudi Dental Journal, 30(4), pp. 273-282. (doi:10.1016/j.sdentj.2018.07.004) (PMID:30202163) (PMCID:PMC6128316)

Delaney, C., Kean, R., Short, B., Tumelty, M., McLean, W., Nile, C. and Ramage, G. (2018) Fungi at the scene of the crime: innocent bystanders or accomplices in oral infections? Current Clinical Microbiology Reports, 5(3), pp. 190-200. (doi:10.1007/s40588-018-0100-3)

McKerlie, R. A. , Rennie, E., Hudda, S., McAllan, W., Al-Ani, Z., McLean, W. and Bagg, J. (2018) Facilitation of student-staff partnership in development of digital learning tools through a special study module. International Journal for Students as Partners, 2(1), pp. 121-129. (doi:10.15173/ijsap.v2i1.3235)

Kean, R., Delaney, C., Rajendran, R., Sherry, L., Metcalfe, R., Thomas, R., McLean, W., Williams, C. and Ramage, G. (2018) Gaining insights from Candida biofilm heterogeneity: one size does not fit all. Journal of Fungi, 4(1), 12. (doi:10.3390/jof4010012) (PMID:29371505) (PMCID:PMC5872315)

2009

Risley, M., Garrod, D., Henkemeyer, M. and McLean, W. (2009) EphB2 and EphB3 forward signalling are required for palate development. Mechanisms of Development, 126(3-4), pp. 230-239. (doi:10.1016/j.mod.2008.10.009) (PMID:19032981)

2008

Wilkosz, S., Epstein, J., de Giorgio-Miller, A., McLean, W., Ireland, G. and Herrick, S. (2008) Remodelling of adipose tissue during experimental omental adhesion formation. British Journal of Surgery, 95(3), pp. 387-396. (doi:10.1002/bjs.6073) (PMID:18278783)

2004

Zeggini, E., Reginato, A. M., Prais, A., Thomson, W., McLean, W. and Donn, R. (2004) Linkage and association studies of discoidin domain receptor 1 (DDR1) single nucleotide polymorphisms (SNPs) in juvenile oligoarthritis. Rheumatology, 43(9), pp. 1138-1141. (doi:10.1093/rheumatology/keh261) (PMID:15213330)

McLean, W. and Olsen, B. R. (2004) Diseases of excess bone formation. In: Bronner, F. and Farach-Carson, M. C. (eds.) Bone Formation. Series: Topics in bone biology (1). Springer: London, pp. 120-137. ISBN 9781849969000 (doi:10.1007/978-1-4471-3777-1_7)

2002

Zelzer, E., McLean, W., Ng, Y.-S., Fukai, N., Reginato, A. M., Lovejoy, S., D'Amore, P. A. and Olsen, B. R. (2002) Skeletal defects in VEGF(120/120) mice reveal multiple roles for VEGF in skeletogenesis. Development, 129(8), pp. 1893-1904. (PMID:11934855)

2001

McLean, W. and Olsen, B. R. (2001) Mouse models of abnormal skeletal development and homeostasis. Trends in Genetics, 17(10), S38-S43. (doi:10.1016/S0168-9525(01)02458-1) (PMID:11585675)

Lavrin, I. O., McLean, W., Seegmiller, R. E., Olsen, B. R. and Hay, E. D. (2001) The mechanism of palatal clefting in the Col11a1 mutant mouse. Archives of Oral Biology, 46(9), pp. 865-869. (doi:10.1016/S0003-9969(01)00044-9) (PMID:11420059)

Rieger, D. K., Reichenberger, E., McLean, W., Sidow, A. and Olsen, B. R. (2001) A double-deletion mutation in the Pitx3 gene causes arrested lens development in aphakia mice. Genomics, 72(1), pp. 61-72. (doi:10.1006/geno.2000.6464) (PMID:11247667)

2000

McLean, W., Lavrin, I.G., Seegmiller, R.E., Archer, C.W., Hay, E.D. and Olsen, B.R. (2000) The mechanism of cleft palate formation in the chondrodysplasia mouse. Teratology Society 40th Annual Meeting, Palm Beach, FL, USA, 24-29 Jun 2000. (doi:10.1002/1096-9926(200006)61:6<435::AID-TERA2>3.0.CO;2-B)

1997

McLean, W., Shepherd, J.P., Brann, C.R. and Westmoreland, D. (1997) Risks associated with occupational glass injury in bar staff with special consideration of hepatitis B infection. Occupational Medicine, 47(3), pp. 147-150. (doi:10.1093/occmed/47.3.147) (PMID:9156469)

1995

Moxham, B.J., McLean, W. and Hall, R.C. (1995) Immunolocalisation of decorin within rat palatal shelves prior to and after shelf elevation. Proceedings of the Anatomical Society of Great Britain and Ireland and the Anatomische Gesellschaft, Southampton, UK, 14-17 Dec 1994.

McLean, W., Brann, C.R., Shepherd, J.P. and Westmorland, D. (1995) Risk of hepatitis B infection through occupational glass injury in bar staff. The British Society for Dental Research (A Division of the IADR) 43rd Annual Meeting, Manchester, UK, 10-13 Apr 1995. (doi:10.1177/00220345950740030801)

McLean, W., Moxham, B.J. and Hall, R.C. (1995) Localisation of decorin and versican within rat palatal shelves during normal palatogenesis. The British Society for Dental Research (A Division of the IADR) 43rd Annual Meeting, Manchester, UK, 10-13 Apr 1995. (doi:10.1177/00220345950740030801)

1994

Hall, R.C., McLean, W., Archer, C.W. and Moxham, B.J. (1994) Molecular heterogeneity of chondroitin sulphate in the developing rat palatal shelves prior to and after shelf elevation. British Connective Tissue Society Meeting, Cardiff, UK, 22-23 Sep 1994.

This list was generated on Wed Jun 19 20:48:08 2019 BST.
Number of items: 18.

Articles

Abusrewil, S. M., McLean, W. and Scott, J. A. (2018) The use of Bioceramics as root-end filling materials in periradicular surgery: a literature review. Saudi Dental Journal, 30(4), pp. 273-282. (doi:10.1016/j.sdentj.2018.07.004) (PMID:30202163) (PMCID:PMC6128316)

Delaney, C., Kean, R., Short, B., Tumelty, M., McLean, W., Nile, C. and Ramage, G. (2018) Fungi at the scene of the crime: innocent bystanders or accomplices in oral infections? Current Clinical Microbiology Reports, 5(3), pp. 190-200. (doi:10.1007/s40588-018-0100-3)

McKerlie, R. A. , Rennie, E., Hudda, S., McAllan, W., Al-Ani, Z., McLean, W. and Bagg, J. (2018) Facilitation of student-staff partnership in development of digital learning tools through a special study module. International Journal for Students as Partners, 2(1), pp. 121-129. (doi:10.15173/ijsap.v2i1.3235)

Kean, R., Delaney, C., Rajendran, R., Sherry, L., Metcalfe, R., Thomas, R., McLean, W., Williams, C. and Ramage, G. (2018) Gaining insights from Candida biofilm heterogeneity: one size does not fit all. Journal of Fungi, 4(1), 12. (doi:10.3390/jof4010012) (PMID:29371505) (PMCID:PMC5872315)

Risley, M., Garrod, D., Henkemeyer, M. and McLean, W. (2009) EphB2 and EphB3 forward signalling are required for palate development. Mechanisms of Development, 126(3-4), pp. 230-239. (doi:10.1016/j.mod.2008.10.009) (PMID:19032981)

Wilkosz, S., Epstein, J., de Giorgio-Miller, A., McLean, W., Ireland, G. and Herrick, S. (2008) Remodelling of adipose tissue during experimental omental adhesion formation. British Journal of Surgery, 95(3), pp. 387-396. (doi:10.1002/bjs.6073) (PMID:18278783)

Zeggini, E., Reginato, A. M., Prais, A., Thomson, W., McLean, W. and Donn, R. (2004) Linkage and association studies of discoidin domain receptor 1 (DDR1) single nucleotide polymorphisms (SNPs) in juvenile oligoarthritis. Rheumatology, 43(9), pp. 1138-1141. (doi:10.1093/rheumatology/keh261) (PMID:15213330)

Zelzer, E., McLean, W., Ng, Y.-S., Fukai, N., Reginato, A. M., Lovejoy, S., D'Amore, P. A. and Olsen, B. R. (2002) Skeletal defects in VEGF(120/120) mice reveal multiple roles for VEGF in skeletogenesis. Development, 129(8), pp. 1893-1904. (PMID:11934855)

McLean, W. and Olsen, B. R. (2001) Mouse models of abnormal skeletal development and homeostasis. Trends in Genetics, 17(10), S38-S43. (doi:10.1016/S0168-9525(01)02458-1) (PMID:11585675)

Lavrin, I. O., McLean, W., Seegmiller, R. E., Olsen, B. R. and Hay, E. D. (2001) The mechanism of palatal clefting in the Col11a1 mutant mouse. Archives of Oral Biology, 46(9), pp. 865-869. (doi:10.1016/S0003-9969(01)00044-9) (PMID:11420059)

Rieger, D. K., Reichenberger, E., McLean, W., Sidow, A. and Olsen, B. R. (2001) A double-deletion mutation in the Pitx3 gene causes arrested lens development in aphakia mice. Genomics, 72(1), pp. 61-72. (doi:10.1006/geno.2000.6464) (PMID:11247667)

McLean, W., Shepherd, J.P., Brann, C.R. and Westmoreland, D. (1997) Risks associated with occupational glass injury in bar staff with special consideration of hepatitis B infection. Occupational Medicine, 47(3), pp. 147-150. (doi:10.1093/occmed/47.3.147) (PMID:9156469)

Book Sections

McLean, W. and Olsen, B. R. (2004) Diseases of excess bone formation. In: Bronner, F. and Farach-Carson, M. C. (eds.) Bone Formation. Series: Topics in bone biology (1). Springer: London, pp. 120-137. ISBN 9781849969000 (doi:10.1007/978-1-4471-3777-1_7)

Conference or Workshop Item

McLean, W., Lavrin, I.G., Seegmiller, R.E., Archer, C.W., Hay, E.D. and Olsen, B.R. (2000) The mechanism of cleft palate formation in the chondrodysplasia mouse. Teratology Society 40th Annual Meeting, Palm Beach, FL, USA, 24-29 Jun 2000. (doi:10.1002/1096-9926(200006)61:6<435::AID-TERA2>3.0.CO;2-B)

Moxham, B.J., McLean, W. and Hall, R.C. (1995) Immunolocalisation of decorin within rat palatal shelves prior to and after shelf elevation. Proceedings of the Anatomical Society of Great Britain and Ireland and the Anatomische Gesellschaft, Southampton, UK, 14-17 Dec 1994.

McLean, W., Brann, C.R., Shepherd, J.P. and Westmorland, D. (1995) Risk of hepatitis B infection through occupational glass injury in bar staff. The British Society for Dental Research (A Division of the IADR) 43rd Annual Meeting, Manchester, UK, 10-13 Apr 1995. (doi:10.1177/00220345950740030801)

McLean, W., Moxham, B.J. and Hall, R.C. (1995) Localisation of decorin and versican within rat palatal shelves during normal palatogenesis. The British Society for Dental Research (A Division of the IADR) 43rd Annual Meeting, Manchester, UK, 10-13 Apr 1995. (doi:10.1177/00220345950740030801)

Hall, R.C., McLean, W., Archer, C.W. and Moxham, B.J. (1994) Molecular heterogeneity of chondroitin sulphate in the developing rat palatal shelves prior to and after shelf elevation. British Connective Tissue Society Meeting, Cardiff, UK, 22-23 Sep 1994.

This list was generated on Wed Jun 19 20:48:08 2019 BST.