Dr Jason Brown

Lecturer in Oral Sciences (Dental School)

378 Sauchiehall Street (Level 8, office K12), Glasgow, Glasgow City, Scotland, United Kingdom, G2 3JZ

Biography

Dr Jason L Brown graduated from Durham University with a BSc (hons) in Biomedical Sciences in 2014 before undertaking a research masters (MPhil) in Dental Microbiology at the University of Liverpool the following academic year. He completed his PhD jointly at the Universities of Glasgow and the West of Scotland in 2018 with a thesis entitled "Cellular Responses in Oral Health and Disease". Subsequently, he worked as a research assistant at the University of Glasgow Dental School in an industrially collaborative project with GlaxoSmithKline for 1.5 years and a National Biofilm Innovation Centre (NBIC) funded project for 0.5 years.

Jason became a research associate in 2021 on a Engineering and Physical Sciences Research Council (EPSRC) collaborative project with the Universities of Bath and Lancaster studying the potential use of plasma technology to combat wound-related biofilms. Jason became a lecturer in Oral Sciences in February 2022. He lectures on a wide range of courses, including the BDS, Nursing and Microbiology undergraduate courses, and plays a pivotal role in the running of the postgraduate taught Oral Sciences course at the University (https://www.gla.ac.uk/postgraduate/taught/oralsciences/) - becoming the programme lead for the academic year, 2023/24.

Jason is an active researcher within the fields of infection biology/microbiology and has had a long-standing research interest in understanding the microbial and host-pathogen interactions in multi-kingdom biofilm infections. The current work conducted in his research group concerns studying novel antimicrobial interventions for biofilm control and profiling of biofilms using unique technologies. This research utilizes a range of microbiological and immunological in vitro systems with an emphasis on studying biofilm models within the context of the oral cavity and skin/wound infections. Jason supervises multiple BSc and MSc level dissertation projects per year, has overseen completion of three PhD projects as secondary supervisor and is currently primary supervisor to another three;

Abdullah Baz (2021-) PhD entitled "Novel therapies for combatting wound infections using biofilm models in vitro"

Muhanna Ali Alshehri (2023-) PhD entitled “Investigating interactions between Candida albicans and oral microorganisms: implications for biofilm control?”

Zainab Bilal (2023-) in collaboration with University of Strathclyde, PhD entitled "Investigating phenotypic changes in wound biofilms in response to antimicrobial treatment using Raman Spectroscopy"

Externally, Dr Brown is a member of several societies including the European Society of Clinical Microbiology and Infectious Diseases and International Association of Dental Research. He is currently the Chair for the Oral Microbiology and Immunology Group, the largest study group of British Society of Dental Research. He is on the Editorial board for Microbiology (Microbiology Society journal) and Senior Editor (Deputy Editor-in-Chief) for the Critical Reviews in Microbiology journal. Jason has served as external examiner for various PhD thesis within his areas of research.

Research interests

Dr Brown has an extensive research background in bacterial, fungal and interkingdom biofilm models relating to different niches within the human body including the oral cavity and the skin. He is also interested in investigating host-pathogen interactions at these mucosal sites using simple and complex organotypic co-culture systems.

Publications

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Jump to: 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018

Number of items: 48.

2025

Allkja, J. et al. (2025) Investigating the prevalence of fungi in diabetic ulcers: an under-recognised contributor to polymicrobial biofilms. APMIS: Journal of Pathology, Microbiology and Immunology, 133(4), e70025. (doi: 10.1111/apm.70025) (PMID:40264255) (PMCID:PMC12015384)

Allkja, J., Bairoliya, S., Bakri, A., Brown, J. , Newby, K., Gilmour, A., Williams, C., Bin, C. and Ramage, G. (2025) A Look into the Microbiome of Diabetic Foot Ulcers: How Does it Impact Patient Outcomes? Microbiology Society Annual Conference 2025, Liverpool, United Kingdom, 31 March - 03 April 2025.

Delaney, C., Sherry, L. and Brown, J. (2025) Implementing Virtual Laboratory Simulations to Enhance Student Engagement and Confidence: a Comparative Study Between Undergraduate and Postgraduate Cohorts. Microbiology Society Annual Conference 2025, Liverpool, United Kingdom, 31 March - 03 April 2025.

Alshehri, M., Alqahtani, S., Murali, P., Delaney, C., Johnston, W. and Brown, J. L. (2025) Organotypic tissue model systems for investigating host-pathogen interactions in vitro. Journal of Visualized Experiments, 28(217), e67487. (doi: 10.3791/67487) (PMID:40228028)

2024

Ashcroft, L., Caldwell, S., Rowan, L., Brown, J. , Hawkins, R., Bradshaw, D., Douglas, C., Ramage, G. and Delaney, C. (2024) Beyond the Oral Microbiome: Investigating the Oral Ecosystem and Disease Development. British Society for Oral and Dental Research (BSODR) Annual Scientific Meeting, Newcastle, United Kingdom, 02-04 September 2024.

Ashcroft, L., Hunt, A., Bradshaw, D., Walker Hall, O., Howlin, R., Pinel, O. and Brown, J. (2024) In the Nooks and Crannies – Biofilm Treatment for the Hard to Reach Areas of a Denture: an In Vitro Study. British Society for Oral and Dental Research (BSODR) Annual Scientific Meeting, Newcastle, United Kingdom, 02-04 September 2024.

Williams, C., Bakri, A., Allkja, J., Short, B., Brown, J. , Delaney, C., Smith, P. and Ramage, G. (2024) Microbiome Analysis of Non-healing Diabetic Foot Ulcers Reveal Distinct Patient Specific Microbiomes Containing Fungi that are Minimally Impacted by Antibiotic Therapy. 34th European Congress of Clinical Microbiology and Infectious Diseases, Barcelona, Spain, 27-30 April 2024.

2023

Baz, A. et al. (2023) Staphylococcus aureus strains exhibit heterogenous tolerance to direct cold atmospheric plasma therapy. Biofilm, 5, 100123. (doi: 10.1016/j.bioflm.2023.100123) (PMID:37138646) (PMCID:PMC10149328)

Johnston, W., Ware, A., Kuiters, W. F., Delaney, C., Brown, J. L. , Hagen, S., Corcoran, D., Cummings, M., Ramage, G. and Kean, R. (2023) In vitro bacterial vaginosis biofilm community manipulation using endolysin therapy. Biofilm, 5, 100101. (doi: 10.1016/j.bioflm.2022.100101) (PMID:36655001) (PMCID:PMC9841237)

Delaney, C., Alapati, S., Alshehri, M., Kubalova, D., Veena, C. L. R., Abusrewil, S., Short, B., Bradshaw, D. and Brown, J. L. (2023) Investigating the role of Candida albicans as a universal substrate for oral bacteria using a transcriptomic approach: implications for interkingdom biofilm control? APMIS: Journal of Pathology, Microbiology and Immunology, 131(11), pp. 601-612. (doi: 10.1111/apm.13327) (PMID:37170476)

Brown, J. , Alqahtani, S., Alshehri, M. A. M., McDonnell, U., Moghaddam, B. and Bradshaw, D. (2023) An In Vitro Co-culture Model System for Investigating Host-pathogen Interactions. British Society for Oral and Dental Research (BSODR) Annual Scientific Meeting, London, United Kingdom, 06-08 September 2023.

Delaney, C., Alshehri, M. A. M., Ramage, G. , Bradshaw, D. and Brown, J. (2023) Understanding the Role of Candida albicans in Interkingdom Oral Biofilms. British Society for Oral and Dental Research (BSODR) Annual Scientific Meeting, London, United Kingdom, 06-08 September 2023.

Brown, J. , Baz, A., Bakri, A., Short, B., Butcher, M., Jenkins, T., Williams, C., Short, R. and Ramage, G. (2023) Cold Atmospheric Plasma Therapy to Combat Skin-related Biofilm Infections. 33rd European Congress of Clinical Microbiology & Infectious Diseases, Copenhagen, Denmark, 15-18 April 2023.

Short, B., Bakri, A., Baz, A., Williams, C., Brown, J. and Ramage, G. (2023) There is more to wounds than bacteria: fungal biofilms in chronic wounds. Current Clinical Microbiology Reports, 10(1), pp. 9-16. (doi: 10.1007/s40588-022-00187-x)

Malcolm, J. et al. (2023) C-terminal citrullinated peptide alters antigen-specific APC:T cell interactions leading to breach of immune tolerance. Journal of Autoimmunity, 135, 102994. (doi: 10.1016/j.jaut.2023.102994) (PMID:36706535)

Brown, J. L. , Butcher, M. C., Ramalingam Veena, C. L., Chogule, S., Johnston, W. and Ramage, G. (2023) Generation of multispecies oral bacteria biofilm models. In: Seymour, Gregory J., Cullinan, Mary P., Heng, Nicholas C. K. and Cooper, Paul R. (eds.) Oral Biology: Molecular Techniques and Applications. Series: Methods in Molecular Biology, 2588. Humana Press: New York, pp. 187-199. ISBN 9781071627792 (doi: 10.1007/978-1-0716-2780-8_12)

2022

Ramage, G. , Short, B., McKloud, E., Alshanta, O. A., Butcher, M., Mclean, W. and Brown, J. L. (2022) Clinical management of fungal biofilm infections. In: Richter, Katharina and Kragh, Kasper Nørskov (eds.) Antibiofilm Strategies: Current and Future Applications to Prevent, Control and Eradicate Biofilms. Series: Springer series on biofilms (vol 11). Springer: Cham, pp. 441-465. ISBN 9783031109911 (doi: 10.1007/978-3-031-10992-8_17)

Abduljalil, H., Bakri, A., Albashaireh, K., Alshanta, O. A., Brown, J. L. , Sherry, L. , Kean, R., Nile, C. , McLean, W. and Ramage, G. (2022) Screening the Tocriscreen™ bioactive compound library in search for inhibitors of Candida biofilm formation. APMIS: Journal of Pathology, Microbiology and Immunology, 130(9), pp. 568-577. (doi: 10.1111/apm.13260) (PMID:35791082)

Brown, J. , Bakri, A., Baz, A., Short, B., Jenkins, T., Short, R., Williams, C. and Ramage, G. (2022) Cold Plasma Therapy for Combatting Skin-related Biofilm Infections. 7th European Congress on Biofilms, Eurobiofilms 2022, Mallorca, Spain, 31 Aug - 03 September 2022.

Short, B., Brown, J. , Baibek, A., Lilienkampf, A., Williams, C., Mackay, W. and Ramage, G. (2022) Developing an Informed Early-colonising Oropharyngeal Biofilm Model in Chronic Obstructive Pulmonary Disease. 7th European Congress on Biofilms, Eurobiofilms, Mallorca, Spain, 31 Aug - 03 September 2022.

Short, B., Brown, J. , Delaney, C., Williams, C., Short, R. and Ramage, G. (2022) Monitoring Diabetic Foot Ulcer Microbiome Dynamics via Bench-top Sequencing. 7th European Congress on Biofilms, Eurobiofilms, Mallorca, Spain, 31 Aug - 03 September 2022.

Gülmez, D., Brown, J. L. , Butcher, M. C., Delaney, C., Kean, R., Ramage, G. and Short, B. (2022) Investigating dual-species Candida auris and staphylococcal biofilm antiseptic challenge. Antibiotics, 11(7), 931. (doi: 10.3390/antibiotics11070931) (PMID:35884184) (PMCID:PMC9312070)

Brown, J. L. , Short, B., Ware, A., Sherry, L. , Kean, R. and Ramage, G. (2022) Cell viability assays for Candida auris. In: Lorenz, A. (ed.) Candida auris. Series: Methods in molecular biology (2517). Humana: New York, pp. 129-153. ISBN 9781071624166 (doi: 10.1007/978-1-0716-2417-3_10)

Brown, J. , Townsend, E., Short, R., Williams, C., Woodall, C., Nile, C. and Ramage, G. (2022) In Vitro Polymicrobial Wound Biofilm Model Systems for Assessing Antimicrobial Treatment Efficacy and Host-pathogen Interactions. 32nd European Congress of Clinical Microbiology & Infectious Diseases, Lisbon, Portugal, 23-26 April 2022.

Brown, J. L. , Townsend, E., Short, R. D., Williams, C., Woodall, C., Nile, C. J. and Ramage, G. (2022) Assessing the inflammatory response to in vitro polymicrobial wound biofilms in a skin epidermis model. npj Biofilms and Microbiomes, 8, 19. (doi: 10.1038/s41522-022-00286-z) (PMID:35393409) (PMCID:PMC8991182)

Brown, J. L. , Young, T., McKloud, E., Butcher, M. C., Bradshaw, D., Pratten, J. R. and Ramage, G. (2022) An in vitro evaluation of denture cleansing regimens against a polymicrobial denture biofilm model. Antibiotics, 11(1), 113. (doi: 10.3390/antibiotics11010113) (PMID:35052990) (PMCID:PMC8772836)

Butcher, M. C., Brown, J. L. , Hansom, D., Wilson-Van Os, R., Delury, C., Laycock, P. A. and Ramage, G. (2022) Antifungal loaded calcium sulfate beads as a potential therapeutic in combating Candida auris. Antimicrobial Agents and Chemotherapy, 66(1), e01713-21. (doi: 10.1128/AAC.01713-21) (PMID:34694875) (PMCID:PMC8765289)

2021

Short, B., Delaney, C., McKloud, E., Brown, J. L. , Kean, R., Litherland, G. J., Williams, C., Martin, S. L., MacKay, W. G. and Ramage, G. (2021) Investigating the transcriptome of Candida albicans in a dual-species Staphylococcus aureus biofilm mode. Frontiers in Cellular and Infection Microbiology, 11, 791523. (doi: 10.3389/fcimb.2021.791523)

Abusrewil, S., Brown, J. L. , Delaney, C., Butcher, M. C., Tiba, M., Scott, J. A. , Ramage, G. and McLean, W. (2021) Chitosan enhances the anti-biofilm activity of biodentine against an interkingdom biofilm model. Antibiotics, 10(11), 1317. (doi: 10.3390/antibiotics10111317)

Śmiga, M., Smalley, J. W., Ślęzak, P., Brown, J. L. , Siemińska, K., Jenkins, R. E., Yates, E. A. and Olczak, T. (2021) Glycation of host proteins increases pathogenic potential of Porphyromonas gingivalis. International Journal of Molecular Sciences, 22(21), 12084. (doi: 10.3390/ijms222112084) (PMID:34769513) (PMCID:PMC8585099)

Butcher, M. C., Brown, J. L. , Hansom, D., Wilson-van Os, R., Delury, C., Laycock, P. A. and Ramage, G. (2021) Assessing the bioactive profile of anti-fungal loaded calcium sulfate against fungal biofilms. Antimicrobial Agents and Chemotherapy, 65(6), e02551-20. (doi: 10.1128/AAC.02551-20) (PMID:33753336)

Johnston, W., Rosier, B.T., Artacho, A., Paterson, M., Piela, K., Delaney, C., Brown, J.L. , Ramage, G. , Mira, A. and Culshaw, S. (2021) Mechanical biofilm disruption causes microbial and immunological shifts in periodontitis patients. Scientific Reports, 11, 9796. (doi: 10.1038/s41598-021-89002-z) (PMID:33963212) (PMCID:PMC8105330)

2020

Young, T., Alshanta, O.-A., Kean, R., Bradshaw, D., Pratten, J., Williams, C., Woodall, C., Ramage, G. and Brown, J. L. (2020) Candida albicans as an essential “keystone” component within polymicrobial oral biofilm models? Microorganisms, 9(1), 59. (doi: 10.3390/microorganisms9010059) (PMID:33379333) (PMCID:PMC7823588)

Abusrewil, S., Brown, J. L. , Delaney, C. D., Butcher, M. C., Kean, R., Gamal, D., Scott, J. A., McLean, W. and Ramage, G. (2020) Filling the void: an optimized polymicrobial interkingdom biofilm model for assessing novel antimicrobial agents in endodontic infection. Microorganisms, 8(12), 1988. (doi: 10.3390/microorganisms8121988) (PMID:33327403) (PMCID:PMC7764896)

Salomão Arias, L., Butcher, M. C., Short, B., McKloud, E., Delaney, C., Kean, R., Monteiro, D. R., Williams, C., Ramage, G. and Brown, J. L. (2020) Chitosan ameliorates Candida auris virulence in a Galleria mellonella infection model. Antimicrobial Agents and Chemotherapy, 64(8), e00476-20. (doi: 10.1128/AAC.00476-20) (PMID:32482674) (PMCID:PMC7526850)

Brown, J. L. , Delaney, C., Short, B., Butcher, M. C., McKloud, E., Williams, C., Kean, R. and Ramage, G. (2020) Candida auris phenotypic heterogeneity determines pathogenicity in vitro. mSphere, 5(3), e00371-20. (doi: 10.1128/mSphere.00371-20) (PMID:32581078) (PMCID:PMC7316489)

Kean, R., Brown, J. , Gulmez, D., Ware, A. and Ramage, G. (2020) Candida auris: a decade of understanding of an enigmatic pathogenic yeast. Journal of Fungi, 6(1), 30. (doi: 10.3390/jof6010030) (PMID:32110970)

Arias, L. S., Brown, J. L. , Butcher, M. C., Delaney, C., Monteiro, D. R. and Ramage, G. (2020) A nanocarrier system that potentiates the effect of miconazole within different interkingdom biofilms. Journal of Oral Microbiology, 12(1), 1771071. (doi: 10.1080/20002297.2020.1771071) (PMID:32922677) (PMCID:PMC7448886)

2019

Delaney, C. et al. (2019) Interkingdom interactions on the denture surface: implications for oral hygiene. Biofilm, 1, 100002. (doi: 10.1016/j.bioflm.2019.100002) (PMID:32201858) (PMCID:PMC7067236)

Brown, J. L. , Johnston, W., Delaney, C., Short, B., Butcher, M. C., Young, T., Butcher, J., Riggio, M. , Culshaw, S. and Ramage, G. (2019) Polymicrobial oral biofilm models: simplifying the complex. Journal of Medical Microbiology, 68(11), pp. 1573-1584. (doi: 10.1099/jmm.0.001063) (PMID:31524581)

Arias, L., Brown, J. , Kean, R. and Ramage, G. (2019) Evaluation of the Antifungal Activity of Chitosan Against Candida auris Using an In Vivo Infection Model. 6th European Congress on Biofilms, Eurobiofilms 2019, Glasgow, United Kingdom, 03-06 September 2019.

Brown, J. , Johnston, W., Delaney, C., Butcher, J., Khan, S., Bradshaw, D., Culshaw, S. and Ramage, G. (2019) Multi-species Oral Biofilms Stimulated Human Gingival Epithelium Differentially Regulates Inflammatory Responses in Co-cultured Immune Cells: a Model to Investigate Cell-signaling in Host-pathogen Interactions. 6th European Congress on Biofilms, Eurobiofilms 2019, Glasgow, United Kingdom, 03-06 September 2019.

Short, B., Brown, J. , Delaney, C., Sherry, L. , Williams, C., Ramage, G. and Kean, R. (2019) Candida auris exhibits resilient biofilm characteristics in vitro: implications for environmental persistence. Journal of Hospital Infection, 103(1), pp. 92-96. 31226270. (doi: 10.1016/j.jhin.2019.06.006)

Brown, J. , Johnston, W., Delaney, C., Butcher, J., Khan, S., Bradshaw, D., Culshaw, S. and Ramage, G. (2019) Oral Biofilm-stimulated Human Gingival Epithelium Differentially Regulates Inflammatory Responses in Co-cultured Immune Cells. Montana Biofilm Science & Technology Meeting, Montana, USA, 16-18 July 2019.

Brown, J. L. , Johnston, W., Delaney, C., Rajendran, R., Butcher, J., Khan, S., Bradshaw, D., Ramage, G. and Culshaw, S. (2019) Biofilm-stimulated epithelium modulates the inflammatory responses in co-cultured immune cells. Scientific Reports, 9, 15779. (doi: 10.1038/s41598-019-52115-7) (PMID:31673005) (PMCID:PMC6823452)

2018

Brown, J.L. , Campbell, L., Malcolm, J. , Adrados Planell, A., Butcher, J.P. and Culshaw, S. (2018) Enrichment of innate lymphoid cell populations in gingival tissue. Journal of Dental Research, 97(12), pp. 1399-1405. (doi: 10.1177/0022034518782141) (PMID:29928824)

Brown, J.L. , Yates, E.A., Bielecki, M., Olczak, T. and Smalley, J.W. (2018) Potential role for Streptococcus gordonii-derived hydrogen peroxide in heme acquisition by Porphyromonas gingivalis. Molecular Oral Microbiology, 33(4), pp. 322-335. (doi: 10.1111/omi.12229) (PMID:29847019)

Brown, J. , Rajendran, R., Khan, S., Bradshaw, D., Butcher, J., Ramage, G. and Culshaw, S. (2018) Structure and Function of a 3D Gingivae-biofilm Interface Model. 96th General Session of the International Association of Dental Research, London, United Kingdom, 25-28 July 2018.

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