Dr Richard Ward

  • Affiliate (School of Chemistry)

email: Richard.Ward@glasgow.ac.uk

R253 Level 2, PharmacologyResearch Theme, Wolfson Link Building, Glasgow G12 8QQ

Import to contacts

Publications

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Jump to: 2022 | 2021 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2004 | 2003
Number of items: 39.

2022

Marsango, S. et al. (2022) The M1 muscarinic receptor is present in situ as a ligand-regulated mixture of monomers and oligomeric complexes. Proceedings of the National Academy of Sciences of the United States of America, 119(24), e220110311. (doi: 10.1073/pnas.2201103119) (PMID:35671422) (PMCID:PMC9214538)

Marsango, S. et al. (2022) Selective phosphorylation of threonine residues defines GPR84-arrestin interactions of biased ligands. Journal of Biological Chemistry, 298(5), 101932. (doi: 10.1016/j.jbc.2022.101932) (PMID:35427647) (PMCID:PMC9118924)

Yu, J. et al. (2022) Dictamnine, a novel c-Met inhibitor, suppresses the proliferation of lung cancer cells by downregulating the PI3K/AKT/mTOR and MAPK signaling pathways. Biochemical Pharmacology, 195, 114864. (doi: 10.1016/j.bcp.2021.114864) (PMID:34861243)

2021

Ward, Richard J., Pediani, John D. ORCID logoORCID: https://orcid.org/0000-0001-6615-537X, Marsango, Sara, Jolly, Richard, Stoneman, Michael R., Biener, Gabriel, Handel, Tracy M., Raicu, Valerica and Milligan, Graeme ORCID logoORCID: https://orcid.org/0000-0002-6946-3519 (2021) Chemokine receptor CXCR4 oligomerization is disrupted selectively by the antagonist ligand IT1t. Journal of Biological Chemistry, 296, 100139. (doi: 10.1074/jbc.RA120.016612) (PMID:33268380)

2019

Stoneman, Michael R., Biener, Gabriel, Ward, Richard J., Pediani, John D. ORCID logoORCID: https://orcid.org/0000-0001-6615-537X, Badu, Dammar, Eis, Annie, Popa, Ionel, Milligan, Graeme ORCID logoORCID: https://orcid.org/0000-0002-6946-3519 and Raicu, Valerică (2019) A general method to quantify ligand-driven oligomerization from fluorescence-based images. Nature Methods, 16(6), pp. 493-496. (doi: 10.1038/s41592-019-0408-9) (PMID:31110281)

Milligan, Graeme ORCID logoORCID: https://orcid.org/0000-0002-6946-3519, Ward, Richard J. and Marsango, Sara (2019) GPCR homo-oligomerization. Current Opinion in Cell Biology, 57, pp. 40-47. (doi: 10.1016/j.ceb.2018.10.007) (PMID:30453145) (PMCID:PMC7083226)

Müskens, Frederike M., Ward, Richard J., Herkt, Dominik, van de Langemheen, Helmus, Tobin, Andrew B. ORCID logoORCID: https://orcid.org/0000-0002-1807-3123, Liskamp, Rob M.J. ORCID logoORCID: https://orcid.org/0000-0001-8897-8975 and Milligan, Graeme ORCID logoORCID: https://orcid.org/0000-0002-6946-3519 (2019) Design, synthesis and evaluation of a diazirine photoaffinity probe for ligand-based receptor capture targeting G protein-coupled receptors. Molecular Pharmacology, 95(2), pp. 196-209. (doi: 10.1124/mol.118.114249) (PMID:30514721) (PMCID:PMC6324650)

2018

Marsango, Sara, Ward, Richard J., Alvarez-Curto, Elisa ORCID logoORCID: https://orcid.org/0000-0003-4004-4545 and Milligan, Graeme ORCID logoORCID: https://orcid.org/0000-0002-6946-3519 (2018) Muscarinic receptor oligomerization. Neuropharmacology, 136(Part C), pp. 401-410. (doi: 10.1016/j.neuropharm.2017.11.023) (PMID:29146505) (PMCID:PMC6078712)

Liu, Y. et al. (2018) Assessing the real-time activation of the cannabinoid CB1 receptor and the associated structural changes using a FRET biosensor. International Journal of Biochemistry and Cell Biology, 99, pp. 114-124. (doi: 10.1016/j.biocel.2018.04.003) (PMID:29626639)

Liu, Y. et al. (2018) Visualization of the activation of the histamine H3 receptor (H3R) using novel fluorescence resonance energy transfer biosensors and their potential application to the study of H3R pharmacology. FEBS Journal, 285(12), pp. 2319-2336. (doi: 10.1111/febs.14484) (PMID:29701013)

Pediani, John D. ORCID logoORCID: https://orcid.org/0000-0001-6615-537X, Ward, Richard J., Marsango, Sara and Milligan, Graeme ORCID logoORCID: https://orcid.org/0000-0002-6946-3519 (2018) Spatial intensity distribution analysis: studies of G Protein-coupled receptor oligomerization. Trends in Pharmacological Sciences, 39(2), pp. 175-186. (doi: 10.1016/j.tips.2017.09.001) (PMID:29032835) (PMCID:PMC5783713)

2017

Ward, Richard J., Marsango, Sara, Pediani, John D. ORCID logoORCID: https://orcid.org/0000-0001-6615-537X and Milligan, Graeme ORCID logoORCID: https://orcid.org/0000-0002-6946-3519 (2017) The use of spatial intensity distribution analysis to examine G protein-coupled receptor oligomerization. In: Herrick-Davis, Katharine, Milligan, Graeme and Di Giovanni, Giuseppe (eds.) G-Protein-Coupled Receptor Dimers. Series: Receptors (33). Humana Press: Cham, pp. 15-38. ISBN 9783319601724 (doi: 10.1007/978-3-319-60174-8_2)

Ward, Richard J., Pediani, John D. ORCID logoORCID: https://orcid.org/0000-0001-6615-537X, Harikumar, Kaleeckal G., Miller, Laurence J. and Milligan, Graeme ORCID logoORCID: https://orcid.org/0000-0002-6946-3519 (2017) Spatial intensity distribution analysis quantifies the extent and regulation of homodimerization of the secretin receptor. Biochemical Journal, 474(11), pp. 1879-1895. (doi: 10.1042/BCJ20170184) (PMID:28424368) (PMCID:PMC5442643)

Marsango, Sara, Caltabiano, Gianluigi, Jiménez-Rosés, Mireia, Millan, Mark J., Pediani, John D. ORCID logoORCID: https://orcid.org/0000-0001-6615-537X, Ward, Richard J. and Milligan, Graeme ORCID logoORCID: https://orcid.org/0000-0002-6946-3519 (2017) A molecular basis for selective antagonist destabilization of dopamine D3 receptor quaternary organization. Scientific Reports, 7, 2134. (doi: 10.1038/s41598-017-02249-3) (PMID:28522847) (PMCID:PMC5437050)

Guo, Hui, An, Su, Ward, Richard J., Yang, Yang, Liu, Ying, Guo, Xiao-Xi, Hao, Qian and Xu, Tian-Rui (2017) Methods used to study the oligomeric structure of G protein-coupled receptors. Bioscience Reports, 37(2), (doi: 10.1042/bsr20160547) (PMID:28062602) (PMCID:PMC5398257)

2016

Liu, Ying, An, Su, Ward, Richard, Yang, Yang, Guo, Xiao, Li, Wei and Xu, Tian-Rui (2016) G protein-coupled receptors as promising cancer targets. Cancer Letters, 376(2), pp. 226-239. (doi: 10.1016/j.canlet.2016.03.031) (PMID:27000991)

Pediani, John D. ORCID logoORCID: https://orcid.org/0000-0001-6615-537X, Ward, Richard J., Godin, Antoine G., Marsango, Sara and Milligan, Graeme ORCID logoORCID: https://orcid.org/0000-0002-6946-3519 (2016) Dynamic regulation of quaternary organization of the M1 muscarinic receptor by subtype-selective antagonist drugs. Journal of Biological Chemistry, 291, pp. 13132-13146. (doi: 10.1074/jbc.M115.712562) (PMID:27080256) (PMCID:PMC4933229)

2015

An, Su, Yang, Yang, Ward, Richard, Liu, Ying, Guo, Xiao-Xi and Xu, Tian-Rui (2015) A-Raf: A new star of the family of raf kinases. Critical Reviews in Biochemistry and Molecular Biology, 50(6), pp. 520-531. (doi: 10.3109/10409238.2015.1102858) (PMID:26508523)

Liste, Maria J., Caltabiano, Gianluigi, Ward, Richard J., Alvarez-Curto, Elisa ORCID logoORCID: https://orcid.org/0000-0003-4004-4545, Marsango, Sara and Milligan, Graeme ORCID logoORCID: https://orcid.org/0000-0002-6946-3519 (2015) The molecular basis of oligomeric organization of the human m3 muscarinic acetylcholine receptor. Molecular Pharmacology, 87(6), pp. 936-953. (doi: 10.1124/mol.114.096925) (PMID:25769304)

Ward, Richard J., Pediani, John D. ORCID logoORCID: https://orcid.org/0000-0001-6615-537X, Godin, Antoine G. and Milligan, Graeme ORCID logoORCID: https://orcid.org/0000-0002-6946-3519 (2015) Regulation of oligomeric organization of the serotonin 5-hydroxytryptamine 2C (5-HT2C) receptor observed by spatial intensity distribution analysis. Journal of Biological Chemistry, 290(20), pp. 12844-12857. (doi: 10.1074/jbc.M115.644724) (PMID:25825490) (PMCID:PMC4432300)

An, Su, Yang, Yang, Ward, Richard, Liu, Ying, Guo, Xiao-Xi and Xu, Tian-Rui (2015) Raf-interactome in tuning the complexity and diversity of Raf function. FEBS Journal, 282(1), pp. 32-53. (doi: 10.1111/febs.13113)

Liu, Y., Yang, Y., Ward, R., An, S., Guo, X.-X., Li, W. and Xu, T.-R. (2015) Biased signalling: the instinctive skill of the cell in the selection of appropriate signalling pathways. Biochemical Journal, 470(2), pp. 155-167. (doi: 10.1042/bj20150358) (PMID:26348905)

2014

Zakrys, Linas, Ward, Richard J., Pediani, John D. ORCID logoORCID: https://orcid.org/0000-0001-6615-537X, Godin, Antoine G., Graham, Gerard J. ORCID logoORCID: https://orcid.org/0000-0002-7801-204X and Milligan, Graeme ORCID logoORCID: https://orcid.org/0000-0002-6946-3519 (2014) Roundabout 1 exists predominantly as a basal dimeric complex and this is unaffected by binding of the ligand Slit2. Biochemical Journal, 461(1), pp. 61-73. (doi: 10.1042/BJ20140190)

Ward, R.J. and Milligan, Graeme ORCID logoORCID: https://orcid.org/0000-0002-6946-3519 (2014) Structural and biophysical characterisation of G protein-coupled receptor ligand binding using resonance energy transfer and fluorescent labelling techniques. Biochimica et Biophysica Acta: Biomembranes, 1838(1A), pp. 3-14. (doi: 10.1016/j.bbamem.2013.04.007)

Yang, Y., Li, H., Ward, R., Gao, L., Wei, J. and Xu, T. (2014) Novel oxytocin receptor agonists and antagonists: a patent review (2002 – 2013). Expert Opinion on Therapeutic Patents, 24(1), pp. 29-46. (doi: 10.1517/13543776.2014.845168)

2013

Xu, T., Yang, Y., Ward, R., Gao, L. and Liu, Y. (2013) Orexin receptors: multi-functional therapeutic targets for sleeping disorders, eating disorders, drug addiction, cancers and other physiological disorders. Cellular Signalling, 25(12), pp. 2413-2423. (doi: 10.1016/j.cellsig.2013.07.025)

Hudson, B.D. et al. (2013) Defining the molecular basis for the first potent and selective orthosteric agonists of the FFA2 free fatty acid receptor. Journal of Biological Chemistry, 288(24), pp. 17296-17312. (doi: 10.1074/jbc.M113.455337)

Ward, R.W., Xu, T.-X. and Milligan, G. ORCID logoORCID: https://orcid.org/0000-0002-6946-3519 (2013) GPCR oligomerization and receptor trafficking. Methods in Enzymology, 521, pp. 69-90. (doi: 10.1016/B978-0-12-391862-8.00004-1)

2012

Xu, Tian-Rui, Ward, Richard J., Pediani, John D. ORCID logoORCID: https://orcid.org/0000-0001-6615-537X and Milligan, Graeme ORCID logoORCID: https://orcid.org/0000-0002-6946-3519 (2012) Intramolecular fluorescence resonance energy transfer (FRET) sensors of the orexin OX1 and OX2 receptors identify slow kinetics of agonist activation. Journal of Biological Chemistry, 287, pp. 14937-14949. (doi: 10.1074/jbc.M111.334300)

Laarman, A.J. et al. (2012) Staphylococcus aureus Staphopain A inhibits CXCR2-dependent neutrophil activation and chemotaxis. EMBO Journal, 31(17), pp. 3607-3619. (doi: 10.1038/emboj.2012.212)

2011

Ward, Richard J., Pediani, John D. ORCID logoORCID: https://orcid.org/0000-0001-6615-537X and Milligan, Graeme ORCID logoORCID: https://orcid.org/0000-0002-6946-3519 (2011) Heteromultimerization of cannabinoid CB1 receptor and orexin OX1 receptor generates a unique complex in which both protomers are regulated by orexin A. Journal of Biological Chemistry, 286(43), pp. 37414-37428. (doi: 10.1074/jbc.M111.287649)

Xu, Tian‑Rui, Ward, Richard J., Pediani, John D. ORCID logoORCID: https://orcid.org/0000-0001-6615-537X and Milligan, Graeme ORCID logoORCID: https://orcid.org/0000-0002-6946-3519 (2011) The orexin OX1 receptor exists predominantly as a homodimer in the basal state: potential regulation of receptor organization by both agonist and antagonist ligands. Biochemical Journal, 439(1), pp. 171-183. (doi: 10.1042/BJ20110230)

Smith, N.J. et al. (2011) Extracellular loop 2 of the free fatty acid receptor 2 mediates allosterism of a phenylacetamide ago-allosteric modulator. Molecular Pharmacology, 80(1), pp. 163-173. (doi: 10.1124/mol.110.070789)

Ward, Richard J., Pediani, John D. ORCID logoORCID: https://orcid.org/0000-0001-6615-537X and Milligan, Graeme ORCID logoORCID: https://orcid.org/0000-0002-6946-3519 (2011) Ligand-induced internalisation of the orexin OX1 and cannabinoid CB1 receptors assessed via N-terminal SNAP and CLIP-tagging. British Journal of Pharmacology, 162(6), pp. 1439-1452. (doi: 10.1111/j.1476-5381.2010.01156.x)

Ward, R.J., Alvarez-Curto, E. ORCID logoORCID: https://orcid.org/0000-0003-4004-4545 and Milligan, G ORCID logoORCID: https://orcid.org/0000-0002-6946-3519 (2011) Using the Flp-In™ T-Rex™ System to Regulate GPCR Expression. Methods in Molecular Biology, 746, pp. 21-37. (doi: 10.1007/978-1-61779-126-0_2)

2010

Alvarez-Curto, Elisa, Ward, Richard J., Pediani, John D. and Milligan, Graeme (2010) Ligand regulation of the quaternary organization of cell surface M3 muscarinic acetylcholine receptors analyzed by fluorescence resonance energy transfer (FRET) imaging and homogenous time-resolved FRET. Journal of Biological Chemistry, 285(30), pp. 23318-23330. (doi: 10.1074/jbc.M110.122184) (PMID:20489201) (PMCID:PMC2906324)

2009

Ward, Richard J., Jenkins, Laura ORCID logoORCID: https://orcid.org/0000-0003-1382-8547 and Milligan, Graeme ORCID logoORCID: https://orcid.org/0000-0002-6946-3519 (2009) Selectivity and functional consequences of interactions of family A G protein-coupled receptors with neurochondrin and periplakin. Journal of Neurochemistry, 109(1), pp. 182-192. (doi: 10.1111/j.1471-4159.2009.05918.x)

2004

Ward, R.J. and Milligan, G. ORCID logoORCID: https://orcid.org/0000-0002-6946-3519 (2004) Analysis of function of receptor-G-protein and receptor-RGS fusion proteins. Methods in Molecular Biology, 259, pp. 225-247. (PMID:15250496)

2003

Bahia, Daljit S., Sartania, Nana ORCID logoORCID: https://orcid.org/0000-0002-3196-2312, Ward, Richard j., Cavalli, Antonella, Jones, Teresa L.Z., Druey, Kirk M. and Milligan, Graeme (2003) Concerted stimulation and deactivation of pertussis toxin-sensitive G proteins by chimeric G protein-coupled receptor-regulator of G protein signaling 4 fusion proteins: analysis of the contribution of palmitoylated cysteine residues to the GAP activity o. Journal of Neurochemistry, 85(5), pp. 1289-1298. (doi: 10.1046/j.1471-4159.2003.01769.x) (PMID:12753087)

This list was generated on Mon Jun 16 00:09:58 2025 BST.
Jump to: Articles | Book Sections
Number of items: 39.

Articles

Marsango, S. et al. (2022) The M1 muscarinic receptor is present in situ as a ligand-regulated mixture of monomers and oligomeric complexes. Proceedings of the National Academy of Sciences of the United States of America, 119(24), e220110311. (doi: 10.1073/pnas.2201103119) (PMID:35671422) (PMCID:PMC9214538)

Marsango, S. et al. (2022) Selective phosphorylation of threonine residues defines GPR84-arrestin interactions of biased ligands. Journal of Biological Chemistry, 298(5), 101932. (doi: 10.1016/j.jbc.2022.101932) (PMID:35427647) (PMCID:PMC9118924)

Yu, J. et al. (2022) Dictamnine, a novel c-Met inhibitor, suppresses the proliferation of lung cancer cells by downregulating the PI3K/AKT/mTOR and MAPK signaling pathways. Biochemical Pharmacology, 195, 114864. (doi: 10.1016/j.bcp.2021.114864) (PMID:34861243)

Ward, Richard J., Pediani, John D. ORCID logoORCID: https://orcid.org/0000-0001-6615-537X, Marsango, Sara, Jolly, Richard, Stoneman, Michael R., Biener, Gabriel, Handel, Tracy M., Raicu, Valerica and Milligan, Graeme ORCID logoORCID: https://orcid.org/0000-0002-6946-3519 (2021) Chemokine receptor CXCR4 oligomerization is disrupted selectively by the antagonist ligand IT1t. Journal of Biological Chemistry, 296, 100139. (doi: 10.1074/jbc.RA120.016612) (PMID:33268380)

Stoneman, Michael R., Biener, Gabriel, Ward, Richard J., Pediani, John D. ORCID logoORCID: https://orcid.org/0000-0001-6615-537X, Badu, Dammar, Eis, Annie, Popa, Ionel, Milligan, Graeme ORCID logoORCID: https://orcid.org/0000-0002-6946-3519 and Raicu, Valerică (2019) A general method to quantify ligand-driven oligomerization from fluorescence-based images. Nature Methods, 16(6), pp. 493-496. (doi: 10.1038/s41592-019-0408-9) (PMID:31110281)

Milligan, Graeme ORCID logoORCID: https://orcid.org/0000-0002-6946-3519, Ward, Richard J. and Marsango, Sara (2019) GPCR homo-oligomerization. Current Opinion in Cell Biology, 57, pp. 40-47. (doi: 10.1016/j.ceb.2018.10.007) (PMID:30453145) (PMCID:PMC7083226)

Müskens, Frederike M., Ward, Richard J., Herkt, Dominik, van de Langemheen, Helmus, Tobin, Andrew B. ORCID logoORCID: https://orcid.org/0000-0002-1807-3123, Liskamp, Rob M.J. ORCID logoORCID: https://orcid.org/0000-0001-8897-8975 and Milligan, Graeme ORCID logoORCID: https://orcid.org/0000-0002-6946-3519 (2019) Design, synthesis and evaluation of a diazirine photoaffinity probe for ligand-based receptor capture targeting G protein-coupled receptors. Molecular Pharmacology, 95(2), pp. 196-209. (doi: 10.1124/mol.118.114249) (PMID:30514721) (PMCID:PMC6324650)

Marsango, Sara, Ward, Richard J., Alvarez-Curto, Elisa ORCID logoORCID: https://orcid.org/0000-0003-4004-4545 and Milligan, Graeme ORCID logoORCID: https://orcid.org/0000-0002-6946-3519 (2018) Muscarinic receptor oligomerization. Neuropharmacology, 136(Part C), pp. 401-410. (doi: 10.1016/j.neuropharm.2017.11.023) (PMID:29146505) (PMCID:PMC6078712)

Liu, Y. et al. (2018) Assessing the real-time activation of the cannabinoid CB1 receptor and the associated structural changes using a FRET biosensor. International Journal of Biochemistry and Cell Biology, 99, pp. 114-124. (doi: 10.1016/j.biocel.2018.04.003) (PMID:29626639)

Liu, Y. et al. (2018) Visualization of the activation of the histamine H3 receptor (H3R) using novel fluorescence resonance energy transfer biosensors and their potential application to the study of H3R pharmacology. FEBS Journal, 285(12), pp. 2319-2336. (doi: 10.1111/febs.14484) (PMID:29701013)

Pediani, John D. ORCID logoORCID: https://orcid.org/0000-0001-6615-537X, Ward, Richard J., Marsango, Sara and Milligan, Graeme ORCID logoORCID: https://orcid.org/0000-0002-6946-3519 (2018) Spatial intensity distribution analysis: studies of G Protein-coupled receptor oligomerization. Trends in Pharmacological Sciences, 39(2), pp. 175-186. (doi: 10.1016/j.tips.2017.09.001) (PMID:29032835) (PMCID:PMC5783713)

Ward, Richard J., Pediani, John D. ORCID logoORCID: https://orcid.org/0000-0001-6615-537X, Harikumar, Kaleeckal G., Miller, Laurence J. and Milligan, Graeme ORCID logoORCID: https://orcid.org/0000-0002-6946-3519 (2017) Spatial intensity distribution analysis quantifies the extent and regulation of homodimerization of the secretin receptor. Biochemical Journal, 474(11), pp. 1879-1895. (doi: 10.1042/BCJ20170184) (PMID:28424368) (PMCID:PMC5442643)

Marsango, Sara, Caltabiano, Gianluigi, Jiménez-Rosés, Mireia, Millan, Mark J., Pediani, John D. ORCID logoORCID: https://orcid.org/0000-0001-6615-537X, Ward, Richard J. and Milligan, Graeme ORCID logoORCID: https://orcid.org/0000-0002-6946-3519 (2017) A molecular basis for selective antagonist destabilization of dopamine D3 receptor quaternary organization. Scientific Reports, 7, 2134. (doi: 10.1038/s41598-017-02249-3) (PMID:28522847) (PMCID:PMC5437050)

Guo, Hui, An, Su, Ward, Richard J., Yang, Yang, Liu, Ying, Guo, Xiao-Xi, Hao, Qian and Xu, Tian-Rui (2017) Methods used to study the oligomeric structure of G protein-coupled receptors. Bioscience Reports, 37(2), (doi: 10.1042/bsr20160547) (PMID:28062602) (PMCID:PMC5398257)

Liu, Ying, An, Su, Ward, Richard, Yang, Yang, Guo, Xiao, Li, Wei and Xu, Tian-Rui (2016) G protein-coupled receptors as promising cancer targets. Cancer Letters, 376(2), pp. 226-239. (doi: 10.1016/j.canlet.2016.03.031) (PMID:27000991)

Pediani, John D. ORCID logoORCID: https://orcid.org/0000-0001-6615-537X, Ward, Richard J., Godin, Antoine G., Marsango, Sara and Milligan, Graeme ORCID logoORCID: https://orcid.org/0000-0002-6946-3519 (2016) Dynamic regulation of quaternary organization of the M1 muscarinic receptor by subtype-selective antagonist drugs. Journal of Biological Chemistry, 291, pp. 13132-13146. (doi: 10.1074/jbc.M115.712562) (PMID:27080256) (PMCID:PMC4933229)

An, Su, Yang, Yang, Ward, Richard, Liu, Ying, Guo, Xiao-Xi and Xu, Tian-Rui (2015) A-Raf: A new star of the family of raf kinases. Critical Reviews in Biochemistry and Molecular Biology, 50(6), pp. 520-531. (doi: 10.3109/10409238.2015.1102858) (PMID:26508523)

Liste, Maria J., Caltabiano, Gianluigi, Ward, Richard J., Alvarez-Curto, Elisa ORCID logoORCID: https://orcid.org/0000-0003-4004-4545, Marsango, Sara and Milligan, Graeme ORCID logoORCID: https://orcid.org/0000-0002-6946-3519 (2015) The molecular basis of oligomeric organization of the human m3 muscarinic acetylcholine receptor. Molecular Pharmacology, 87(6), pp. 936-953. (doi: 10.1124/mol.114.096925) (PMID:25769304)

Ward, Richard J., Pediani, John D. ORCID logoORCID: https://orcid.org/0000-0001-6615-537X, Godin, Antoine G. and Milligan, Graeme ORCID logoORCID: https://orcid.org/0000-0002-6946-3519 (2015) Regulation of oligomeric organization of the serotonin 5-hydroxytryptamine 2C (5-HT2C) receptor observed by spatial intensity distribution analysis. Journal of Biological Chemistry, 290(20), pp. 12844-12857. (doi: 10.1074/jbc.M115.644724) (PMID:25825490) (PMCID:PMC4432300)

An, Su, Yang, Yang, Ward, Richard, Liu, Ying, Guo, Xiao-Xi and Xu, Tian-Rui (2015) Raf-interactome in tuning the complexity and diversity of Raf function. FEBS Journal, 282(1), pp. 32-53. (doi: 10.1111/febs.13113)

Liu, Y., Yang, Y., Ward, R., An, S., Guo, X.-X., Li, W. and Xu, T.-R. (2015) Biased signalling: the instinctive skill of the cell in the selection of appropriate signalling pathways. Biochemical Journal, 470(2), pp. 155-167. (doi: 10.1042/bj20150358) (PMID:26348905)

Zakrys, Linas, Ward, Richard J., Pediani, John D. ORCID logoORCID: https://orcid.org/0000-0001-6615-537X, Godin, Antoine G., Graham, Gerard J. ORCID logoORCID: https://orcid.org/0000-0002-7801-204X and Milligan, Graeme ORCID logoORCID: https://orcid.org/0000-0002-6946-3519 (2014) Roundabout 1 exists predominantly as a basal dimeric complex and this is unaffected by binding of the ligand Slit2. Biochemical Journal, 461(1), pp. 61-73. (doi: 10.1042/BJ20140190)

Ward, R.J. and Milligan, Graeme ORCID logoORCID: https://orcid.org/0000-0002-6946-3519 (2014) Structural and biophysical characterisation of G protein-coupled receptor ligand binding using resonance energy transfer and fluorescent labelling techniques. Biochimica et Biophysica Acta: Biomembranes, 1838(1A), pp. 3-14. (doi: 10.1016/j.bbamem.2013.04.007)

Yang, Y., Li, H., Ward, R., Gao, L., Wei, J. and Xu, T. (2014) Novel oxytocin receptor agonists and antagonists: a patent review (2002 – 2013). Expert Opinion on Therapeutic Patents, 24(1), pp. 29-46. (doi: 10.1517/13543776.2014.845168)

Xu, T., Yang, Y., Ward, R., Gao, L. and Liu, Y. (2013) Orexin receptors: multi-functional therapeutic targets for sleeping disorders, eating disorders, drug addiction, cancers and other physiological disorders. Cellular Signalling, 25(12), pp. 2413-2423. (doi: 10.1016/j.cellsig.2013.07.025)

Hudson, B.D. et al. (2013) Defining the molecular basis for the first potent and selective orthosteric agonists of the FFA2 free fatty acid receptor. Journal of Biological Chemistry, 288(24), pp. 17296-17312. (doi: 10.1074/jbc.M113.455337)

Ward, R.W., Xu, T.-X. and Milligan, G. ORCID logoORCID: https://orcid.org/0000-0002-6946-3519 (2013) GPCR oligomerization and receptor trafficking. Methods in Enzymology, 521, pp. 69-90. (doi: 10.1016/B978-0-12-391862-8.00004-1)

Xu, Tian-Rui, Ward, Richard J., Pediani, John D. ORCID logoORCID: https://orcid.org/0000-0001-6615-537X and Milligan, Graeme ORCID logoORCID: https://orcid.org/0000-0002-6946-3519 (2012) Intramolecular fluorescence resonance energy transfer (FRET) sensors of the orexin OX1 and OX2 receptors identify slow kinetics of agonist activation. Journal of Biological Chemistry, 287, pp. 14937-14949. (doi: 10.1074/jbc.M111.334300)

Laarman, A.J. et al. (2012) Staphylococcus aureus Staphopain A inhibits CXCR2-dependent neutrophil activation and chemotaxis. EMBO Journal, 31(17), pp. 3607-3619. (doi: 10.1038/emboj.2012.212)

Ward, Richard J., Pediani, John D. ORCID logoORCID: https://orcid.org/0000-0001-6615-537X and Milligan, Graeme ORCID logoORCID: https://orcid.org/0000-0002-6946-3519 (2011) Heteromultimerization of cannabinoid CB1 receptor and orexin OX1 receptor generates a unique complex in which both protomers are regulated by orexin A. Journal of Biological Chemistry, 286(43), pp. 37414-37428. (doi: 10.1074/jbc.M111.287649)

Xu, Tian‑Rui, Ward, Richard J., Pediani, John D. ORCID logoORCID: https://orcid.org/0000-0001-6615-537X and Milligan, Graeme ORCID logoORCID: https://orcid.org/0000-0002-6946-3519 (2011) The orexin OX1 receptor exists predominantly as a homodimer in the basal state: potential regulation of receptor organization by both agonist and antagonist ligands. Biochemical Journal, 439(1), pp. 171-183. (doi: 10.1042/BJ20110230)

Smith, N.J. et al. (2011) Extracellular loop 2 of the free fatty acid receptor 2 mediates allosterism of a phenylacetamide ago-allosteric modulator. Molecular Pharmacology, 80(1), pp. 163-173. (doi: 10.1124/mol.110.070789)

Ward, Richard J., Pediani, John D. ORCID logoORCID: https://orcid.org/0000-0001-6615-537X and Milligan, Graeme ORCID logoORCID: https://orcid.org/0000-0002-6946-3519 (2011) Ligand-induced internalisation of the orexin OX1 and cannabinoid CB1 receptors assessed via N-terminal SNAP and CLIP-tagging. British Journal of Pharmacology, 162(6), pp. 1439-1452. (doi: 10.1111/j.1476-5381.2010.01156.x)

Ward, R.J., Alvarez-Curto, E. ORCID logoORCID: https://orcid.org/0000-0003-4004-4545 and Milligan, G ORCID logoORCID: https://orcid.org/0000-0002-6946-3519 (2011) Using the Flp-In™ T-Rex™ System to Regulate GPCR Expression. Methods in Molecular Biology, 746, pp. 21-37. (doi: 10.1007/978-1-61779-126-0_2)

Alvarez-Curto, Elisa, Ward, Richard J., Pediani, John D. and Milligan, Graeme (2010) Ligand regulation of the quaternary organization of cell surface M3 muscarinic acetylcholine receptors analyzed by fluorescence resonance energy transfer (FRET) imaging and homogenous time-resolved FRET. Journal of Biological Chemistry, 285(30), pp. 23318-23330. (doi: 10.1074/jbc.M110.122184) (PMID:20489201) (PMCID:PMC2906324)

Ward, Richard J., Jenkins, Laura ORCID logoORCID: https://orcid.org/0000-0003-1382-8547 and Milligan, Graeme ORCID logoORCID: https://orcid.org/0000-0002-6946-3519 (2009) Selectivity and functional consequences of interactions of family A G protein-coupled receptors with neurochondrin and periplakin. Journal of Neurochemistry, 109(1), pp. 182-192. (doi: 10.1111/j.1471-4159.2009.05918.x)

Ward, R.J. and Milligan, G. ORCID logoORCID: https://orcid.org/0000-0002-6946-3519 (2004) Analysis of function of receptor-G-protein and receptor-RGS fusion proteins. Methods in Molecular Biology, 259, pp. 225-247. (PMID:15250496)

Bahia, Daljit S., Sartania, Nana ORCID logoORCID: https://orcid.org/0000-0002-3196-2312, Ward, Richard j., Cavalli, Antonella, Jones, Teresa L.Z., Druey, Kirk M. and Milligan, Graeme (2003) Concerted stimulation and deactivation of pertussis toxin-sensitive G proteins by chimeric G protein-coupled receptor-regulator of G protein signaling 4 fusion proteins: analysis of the contribution of palmitoylated cysteine residues to the GAP activity o. Journal of Neurochemistry, 85(5), pp. 1289-1298. (doi: 10.1046/j.1471-4159.2003.01769.x) (PMID:12753087)

Book Sections

Ward, Richard J., Marsango, Sara, Pediani, John D. ORCID logoORCID: https://orcid.org/0000-0001-6615-537X and Milligan, Graeme ORCID logoORCID: https://orcid.org/0000-0002-6946-3519 (2017) The use of spatial intensity distribution analysis to examine G protein-coupled receptor oligomerization. In: Herrick-Davis, Katharine, Milligan, Graeme and Di Giovanni, Giuseppe (eds.) G-Protein-Coupled Receptor Dimers. Series: Receptors (33). Humana Press: Cham, pp. 15-38. ISBN 9783319601724 (doi: 10.1007/978-3-319-60174-8_2)

This list was generated on Mon Jun 16 00:09:58 2025 BST.

Research datasets

Jump to: 2022
Number of items: 1.

2022

Marsango, S., Jenkins, L. , Pediani, J. , Bradley, S. , Ward, R., Hesse, S. and Milligan, G. (2022) The M1 muscarinic receptor is present in situ as a ligand-regulated mixture of monomers and oligomeric complexes. [Data Collection]

This list was generated on Sun Jun 15 19:34:06 2025 BST.