Dr Alexander Harkiss
- Honorary Research Associate (School of Chemistry)
email:
Alexander.Harkiss@glasgow.ac.uk
School of Chemistry, Joseph Black Building, University of Glasgow, Glasgow, G12 8QQ
Biography
Research Associate in the Cooke Research Group
Research interests
Research groups
Publications
2024
Riley, Leanne M. ORCID: https://orcid.org/0000-0003-0615-9752, Marshall, Olivia, Harkiss, Alexander H., Senn, Hans M.
ORCID: https://orcid.org/0000-0001-8232-5957 and Sutherland, Andrew
ORCID: https://orcid.org/0000-0001-7907-5766
(2024)
Synthesis of β-pyridyl α-amino acids: conformationally sensitive charge transfer-based fluorophores.
Organic Letters, 26(25),
pp. 5391-5395.
(doi: 10.1021/acs.orglett.4c01951)
(PMID:38865167)
(PMCID:PMC11217948)
2023
Songsri, Sineenard, Harkiss, Alexander H. and Sutherland, Andrew ORCID: https://orcid.org/0000-0001-7907-5766
(2023)
Synthesis and photophysical properties of charge-transfer based pyrimidine-derived ∝-amino acids.
Journal of Organic Chemistry, 88(18),
pp. 13214-13224.
(doi: 10.1021/acs.joc.3c01437)
(PMID:37621156)
(PMCID:PMC10507667)
Uno, Shinpei, Harkiss, Alexander H., Chowdhury, Roy, Caldwell, Stuart T. ORCID: https://orcid.org/0000-0003-1604-3462, Prime, Tracy A., James, Andrew M., Gallagher, Brendan, Prudent, Julien, Hartley, Richard C.
ORCID: https://orcid.org/0000-0003-1033-5405 and Murphy, Michael P.
(2023)
Incorporating a polyethyleneglycol linker to enhance the hydrophilicity of mitochondria‐targeted triphenylphosphonium constructs.
ChemBioChem, 24(11),
e202200774.
(doi: 10.1002/cbic.202200774)
(PMID:36917207)
(PMCID:PMC10946768)
2022
Cariello, Michele ORCID: https://orcid.org/0000-0001-9699-3710, Pant, Namrata, Harkiss, Alexander H., Tracey, Frances M., Cameron, Joseph
ORCID: https://orcid.org/0000-0001-8622-8353, Skabara, Peter J.
ORCID: https://orcid.org/0000-0001-7319-0464, Holliman, Peter J., Docampo, Pablo
ORCID: https://orcid.org/0000-0001-6164-4748 and Cooke, Graeme
ORCID: https://orcid.org/0000-0003-0890-5720
(2022)
Synthesis of SOT-OH and its application as a building block for the synthesis of new dimeric and trimeric Spiro-OMeTAD materials.
Molecular Systems Design and Engineering, 7(8),
pp. 899-905.
(doi: 10.1039/D2ME00038E)
2020
Bell, Jonathan D., Harkiss, Alexander H., Nobis, David, Malcolm, Eilidh, Knuhtsen, Astrid, Wellaway, Christopher R., Jamieson, Andrew G. ORCID: https://orcid.org/0000-0003-1726-7353, Magennis, Steven W.
ORCID: https://orcid.org/0000-0002-4327-8366 and Sutherland, Andrew
ORCID: https://orcid.org/0000-0001-7907-5766
(2020)
Conformationally rigid pyrazoloquinazoline α-amino acids: one- and two-photon induced fluorescence.
Chemical Communications, 56(12),
pp. 1887-1890.
(doi: 10.1039/C9CC09064A)
(PMID:31956866)
2019
Bell, Jonathan D., Morgan, Timaeus E.F., Buijs, Ned, Harkiss, Alexander H., Wellaway, Christopher R. and Sutherland, Andrew ORCID: https://orcid.org/0000-0001-7907-5766
(2019)
Synthesis and photophysical properties of benzotriazole-derived unnatural α -amino acids.
Journal of Organic Chemistry, 84(16),
pp. 10436-10448.
(doi: 10.1021/acs.joc.9b01685)
(PMID:31340638)
Harkiss, Alexander H., Bell, Jonathan D., Knuhtsen, Astrid, Jamieson, Andrew G. ORCID: https://orcid.org/0000-0003-1726-7353 and Sutherland, Andrew
ORCID: https://orcid.org/0000-0001-7907-5766
(2019)
Synthesis and fluorescent properties of β-pyridyl α-amino acids.
Journal of Organic Chemistry, 84(5),
pp. 2879-2890.
(doi: 10.1021/acs.joc.9b00036)
(PMID:30726078)
2018
Bell, Jonathan D., Harkiss, Alexander H., Wellaway, Christopher R. and Sutherland, Andrew ORCID: https://orcid.org/0000-0001-7907-5766
(2018)
Stereoselective synthesis of 2,6-trans-4-oxopiperidines using an acid-mediated 6-endo-trig cyclisation.
Organic and Biomolecular Chemistry, 16(35),
pp. 6410-6422.
(doi: 10.1039/C8OB01363B)
(PMID:30011344)
Harkiss, Alexander H. and Sutherland, Andrew ORCID: https://orcid.org/0000-0001-7907-5766
(2018)
Access to 2,6-disubstituted 4-oxopiperidines using a 6-endo-trig cyclization: stereoselective synthesis of spruce alkaloid and (+)-241D.
Journal of Organic Chemistry, 83(1),
pp. 535-542.
(doi: 10.1021/acs.joc.7b02799)
(PMID:29218988)
2016
Sharif, Salaheddin A.I., Calder, Ewen D.D., Harkiss, Alexander, Maduro, Marie and Sutherland, Andrew ORCID: https://orcid.org/0000-0001-7907-5766
(2016)
Synthesis of allylic amide functionalized 2H-chromenes and coumarins using a one-pot overman rearrangement and gold(I)-catalyzed hydroarylation.
Journal of Organic Chemistry, 81(20),
pp. 9810-9819.
(doi: 10.1021/acs.joc.6b01881)
(PMID:27680202)
Harkiss, Alexander and Sutherland, Andrew ORCID: https://orcid.org/0000-0001-7907-5766
(2016)
Recent advances in the synthesis and application of fluorescent α-amino acids.
Organic and Biomolecular Chemistry, 14(38),
pp. 8911-8921.
(doi: 10.1039/C6OB01715K)
(PMID:27714204)
2015
Gilfillan, Lynne, Artschwager, Raik, Harkiss, Alexander H., Liskamp, Rob M.J. ORCID: https://orcid.org/0000-0001-8897-8975 and Sutherland, Andrew
ORCID: https://orcid.org/0000-0001-7907-5766
(2015)
Synthesis of pyrazole containing α-amino acids via a highly regioselective condensation/aza-Michael reaction of β-aryl α,β-unsaturated ketones.
Organic and Biomolecular Chemistry, 13(15),
pp. 4514-4523.
(doi: 10.1039/C5OB00364D)
(PMID:25774874)
2014
Calder, Ewen D.D., McGonagle, Fiona I., Harkiss, Alexander H., McGonagle, Grant A. and Sutherland, Andrew ORCID: https://orcid.org/0000-0001-7907-5766
(2014)
Preparation of amino-substituted indenes and 1,4-dihydronaphthalenes using a one-pot multireaction approach: total synthesis of oxybenzo[c]phenanthridine alkaloids.
Journal of Organic Chemistry, 79(16),
pp. 7633-7648.
(doi: 10.1021/jo5014492)
(PMID:25060853)
Articles
Riley, Leanne M. ORCID: https://orcid.org/0000-0003-0615-9752, Marshall, Olivia, Harkiss, Alexander H., Senn, Hans M.
ORCID: https://orcid.org/0000-0001-8232-5957 and Sutherland, Andrew
ORCID: https://orcid.org/0000-0001-7907-5766
(2024)
Synthesis of β-pyridyl α-amino acids: conformationally sensitive charge transfer-based fluorophores.
Organic Letters, 26(25),
pp. 5391-5395.
(doi: 10.1021/acs.orglett.4c01951)
(PMID:38865167)
(PMCID:PMC11217948)
Songsri, Sineenard, Harkiss, Alexander H. and Sutherland, Andrew ORCID: https://orcid.org/0000-0001-7907-5766
(2023)
Synthesis and photophysical properties of charge-transfer based pyrimidine-derived ∝-amino acids.
Journal of Organic Chemistry, 88(18),
pp. 13214-13224.
(doi: 10.1021/acs.joc.3c01437)
(PMID:37621156)
(PMCID:PMC10507667)
Uno, Shinpei, Harkiss, Alexander H., Chowdhury, Roy, Caldwell, Stuart T. ORCID: https://orcid.org/0000-0003-1604-3462, Prime, Tracy A., James, Andrew M., Gallagher, Brendan, Prudent, Julien, Hartley, Richard C.
ORCID: https://orcid.org/0000-0003-1033-5405 and Murphy, Michael P.
(2023)
Incorporating a polyethyleneglycol linker to enhance the hydrophilicity of mitochondria‐targeted triphenylphosphonium constructs.
ChemBioChem, 24(11),
e202200774.
(doi: 10.1002/cbic.202200774)
(PMID:36917207)
(PMCID:PMC10946768)
Cariello, Michele ORCID: https://orcid.org/0000-0001-9699-3710, Pant, Namrata, Harkiss, Alexander H., Tracey, Frances M., Cameron, Joseph
ORCID: https://orcid.org/0000-0001-8622-8353, Skabara, Peter J.
ORCID: https://orcid.org/0000-0001-7319-0464, Holliman, Peter J., Docampo, Pablo
ORCID: https://orcid.org/0000-0001-6164-4748 and Cooke, Graeme
ORCID: https://orcid.org/0000-0003-0890-5720
(2022)
Synthesis of SOT-OH and its application as a building block for the synthesis of new dimeric and trimeric Spiro-OMeTAD materials.
Molecular Systems Design and Engineering, 7(8),
pp. 899-905.
(doi: 10.1039/D2ME00038E)
Bell, Jonathan D., Harkiss, Alexander H., Nobis, David, Malcolm, Eilidh, Knuhtsen, Astrid, Wellaway, Christopher R., Jamieson, Andrew G. ORCID: https://orcid.org/0000-0003-1726-7353, Magennis, Steven W.
ORCID: https://orcid.org/0000-0002-4327-8366 and Sutherland, Andrew
ORCID: https://orcid.org/0000-0001-7907-5766
(2020)
Conformationally rigid pyrazoloquinazoline α-amino acids: one- and two-photon induced fluorescence.
Chemical Communications, 56(12),
pp. 1887-1890.
(doi: 10.1039/C9CC09064A)
(PMID:31956866)
Bell, Jonathan D., Morgan, Timaeus E.F., Buijs, Ned, Harkiss, Alexander H., Wellaway, Christopher R. and Sutherland, Andrew ORCID: https://orcid.org/0000-0001-7907-5766
(2019)
Synthesis and photophysical properties of benzotriazole-derived unnatural α -amino acids.
Journal of Organic Chemistry, 84(16),
pp. 10436-10448.
(doi: 10.1021/acs.joc.9b01685)
(PMID:31340638)
Harkiss, Alexander H., Bell, Jonathan D., Knuhtsen, Astrid, Jamieson, Andrew G. ORCID: https://orcid.org/0000-0003-1726-7353 and Sutherland, Andrew
ORCID: https://orcid.org/0000-0001-7907-5766
(2019)
Synthesis and fluorescent properties of β-pyridyl α-amino acids.
Journal of Organic Chemistry, 84(5),
pp. 2879-2890.
(doi: 10.1021/acs.joc.9b00036)
(PMID:30726078)
Bell, Jonathan D., Harkiss, Alexander H., Wellaway, Christopher R. and Sutherland, Andrew ORCID: https://orcid.org/0000-0001-7907-5766
(2018)
Stereoselective synthesis of 2,6-trans-4-oxopiperidines using an acid-mediated 6-endo-trig cyclisation.
Organic and Biomolecular Chemistry, 16(35),
pp. 6410-6422.
(doi: 10.1039/C8OB01363B)
(PMID:30011344)
Harkiss, Alexander H. and Sutherland, Andrew ORCID: https://orcid.org/0000-0001-7907-5766
(2018)
Access to 2,6-disubstituted 4-oxopiperidines using a 6-endo-trig cyclization: stereoselective synthesis of spruce alkaloid and (+)-241D.
Journal of Organic Chemistry, 83(1),
pp. 535-542.
(doi: 10.1021/acs.joc.7b02799)
(PMID:29218988)
Sharif, Salaheddin A.I., Calder, Ewen D.D., Harkiss, Alexander, Maduro, Marie and Sutherland, Andrew ORCID: https://orcid.org/0000-0001-7907-5766
(2016)
Synthesis of allylic amide functionalized 2H-chromenes and coumarins using a one-pot overman rearrangement and gold(I)-catalyzed hydroarylation.
Journal of Organic Chemistry, 81(20),
pp. 9810-9819.
(doi: 10.1021/acs.joc.6b01881)
(PMID:27680202)
Harkiss, Alexander and Sutherland, Andrew ORCID: https://orcid.org/0000-0001-7907-5766
(2016)
Recent advances in the synthesis and application of fluorescent α-amino acids.
Organic and Biomolecular Chemistry, 14(38),
pp. 8911-8921.
(doi: 10.1039/C6OB01715K)
(PMID:27714204)
Gilfillan, Lynne, Artschwager, Raik, Harkiss, Alexander H., Liskamp, Rob M.J. ORCID: https://orcid.org/0000-0001-8897-8975 and Sutherland, Andrew
ORCID: https://orcid.org/0000-0001-7907-5766
(2015)
Synthesis of pyrazole containing α-amino acids via a highly regioselective condensation/aza-Michael reaction of β-aryl α,β-unsaturated ketones.
Organic and Biomolecular Chemistry, 13(15),
pp. 4514-4523.
(doi: 10.1039/C5OB00364D)
(PMID:25774874)
Calder, Ewen D.D., McGonagle, Fiona I., Harkiss, Alexander H., McGonagle, Grant A. and Sutherland, Andrew ORCID: https://orcid.org/0000-0001-7907-5766
(2014)
Preparation of amino-substituted indenes and 1,4-dihydronaphthalenes using a one-pot multireaction approach: total synthesis of oxybenzo[c]phenanthridine alkaloids.
Journal of Organic Chemistry, 79(16),
pp. 7633-7648.
(doi: 10.1021/jo5014492)
(PMID:25060853)
Research datasets
2025
Harkiss, A. H., Warrington, S., Caldwell, S. T. and Hartley, R. C. (2025) Simultaneous and sensitive quantification of protein and low molecular weight persulfides, polysulfides and H2S in biological samples. [Data Collection]
2023
Uno, S., Harkiss, A., Chowdhury, R., Caldwell, S. , Prime, T. A., James, A. M., Gallagher, B., Prudent, J., Hartley, R. and Murphy, M. (2023) Incorporating a Polyethyleneglycol Linker to Enhance the Hydrophilicity of Mitochondria-Targeted Triphenylphosphonium Constructs. [Data Collection]
