Dr Adrian Lapthorn

  • Senior Lecturer (School of Chemistry)

telephone: 01413305940
email: Adrian.Lapthorn@glasgow.ac.uk

Room B3-06, Chemistry, Joseph Black Building, Glasgow G12 8QQ

Import to contacts

ORCID iDhttps://orcid.org/0000-0002-2197-8134

Research interests

Research Interests

My research interests are in using the technique of protein crystallography to elucidate protein structure with an aim to answering important questions on protein function and mechanism. I also have a specific interest in protein-protein interactions. Protein Structure and Function; Enzymes of the Shikimate pathway; Structure aided drug discovery; Protein Crystallography; Plant Glutathione S-transferases.

Research Topics

Protein Structure and Function
Enzymes of the Shikimate pathway
Structure aided drug discovery
Protein Crystallography
Plant Glutathione S-transferases

Publication Highlights

"Binding and glutathione conjugation of porphyrinogens by plant glutathione transferases". Dixon, D.P., Lapthorn, A.J., Madesis, P., Mudd, E.A., Day, A. and Edwards, R. J. Biol. Chem. 283, 20268-20276 (2008)

"Design, synthesis, and structural studies on potent biaryl inhibitors of type II dehydroquinases". Payne, R.J., Riboldi-Tunnicliffe, A., Kerbarh, O., Abell, A.D., Lapthorn, A.J. and Abell, C. ChemMedChem, 2, 1010-1013 (2007)

"Crystal structures of Helicobacter pylori type II dehydroquinase inhibitor complexes: New directions for inhibitor design". D.A. Robinson, K.A. Stewart, N.C. Price, P.A. Chalk, J.R. Coggins, A.J. Lapthorn, J. Med. Chem., 49, 1282-1290 (2006)

"Crystal structure of mouse succinic semialdehyde reductase AKR7A5: Structural basis for substrate specificity". X.F. Zhu, A.J. Lapthorn, E.M. Ellis, Biochemistry, 45, 1562-1570 (2006)

"The structure of Escherichia coli ATP-phosphoribosyltransferase: Identification of substrate binding sites and mode of AMP inhibition". B. Lohkamp, G. McDermott, S.A. Campbell, J.R. Coggins, A.J. Lapthorn, J. Mol. Biol., 336, 131-144 (2004)

 

 

Research groups

Publications

List by: Type | Date

Jump to: 2024 | 2023 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2011 | 2010 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000 | 1998 | 1997 | 1996 | 1995 | 1994 | 1993
Number of items: 61.

2024

Cardwell, Patrick A., Del Moro, Carlo, Murphy, Michael P., Lapthorn, Adrian J. ORCID logoORCID: https://orcid.org/0000-0002-2197-8134 and Hartley, Richard C. ORCID logoORCID: https://orcid.org/0000-0003-1033-5405 (2024) Human mitochondrial glutathione transferases: Kinetic parameters and accommodation of a mitochondria-targeting group in substrates. Bioorganic and Medicinal Chemistry, 104, 117712. (doi: 10.1016/j.bmc.2024.117712) (PMID:38593670)

2023

Wallace, S. et al. (2023) Multiplexed biosensing of proteins and virions with disposable plasmonic assays. ACS Sensors, 8(9), pp. 3338-3348. (doi: 10.1021/acssensors.2c02238) (PMID:37610841) (PMCID:PMC10521139)

2020

Kakkar, T. et al. (2020) Superchiral near fields detect virus structure. Light: Science and Applications, 9(1), 195. (doi: 10.1038/s41377-020-00433-1) (PMID:33298854) (PMCID:PMC7705013)

Rodier, Marion, Keijzer, Chantal, Milner, Joel ORCID logoORCID: https://orcid.org/0000-0003-3702-4295, Karimullah, Affar Shahid ORCID logoORCID: https://orcid.org/0000-0002-8792-9829, Barron, Laurence, Gadegaard, Nikolaj ORCID logoORCID: https://orcid.org/0000-0002-3396-846X, Lapthorn, Adrian J. ORCID logoORCID: https://orcid.org/0000-0002-2197-8134 and Kadodwala, Malcolm ORCID logoORCID: https://orcid.org/0000-0003-4989-5688 (2020) Biomacromolecular charge chirality detected using chiral plasmonic nanostructures. Nanoscale Horizons, 5, pp. 336-344. (doi: 10.1039/C9NH00525K)

2019

Rodier, Marion, Keijzer, Chantal, Milner, Joel ORCID logoORCID: https://orcid.org/0000-0003-3702-4295, Karimullah, Affar ORCID logoORCID: https://orcid.org/0000-0002-8792-9829, Barron, Laurence, Gadegaard, Nikolaj ORCID logoORCID: https://orcid.org/0000-0002-3396-846X, Lapthorn, Adrian ORCID logoORCID: https://orcid.org/0000-0002-2197-8134 and Kadodwala, Malcolm ORCID logoORCID: https://orcid.org/0000-0003-4989-5688 (2019) Probing specificity of protein-protein interactions with chiral plasmonic nanostructures. Journal of Physical Chemistry Letters, 10, pp. 6105-6111. (doi: 10.1021/acs.jpclett.9b02288) (PMID:31549842)

2018

Kelly, Christopher, Tullius, Ryan, Lapthorn, Adrian J. ORCID logoORCID: https://orcid.org/0000-0002-2197-8134, Gadegaard, Nikolaj ORCID logoORCID: https://orcid.org/0000-0002-3396-846X, Cooke, Graeme ORCID logoORCID: https://orcid.org/0000-0003-0890-5720, Barron, Laurence D., Karimullah, Affar S. ORCID logoORCID: https://orcid.org/0000-0002-8792-9829, Rotello, Vincent M. and Kadodwala, Malcolm ORCID logoORCID: https://orcid.org/0000-0003-4989-5688 (2018) Chiral plasmonic fields probe structural order of biointerfaces. Journal of the American Chemical Society, 140(27), pp. 8509-8517. (doi: 10.1021/jacs.8b03634) (PMID:29909628)

2017

Tullius, R. et al. (2017) Superchiral plasmonic phase sensitivity for fingerprinting of protein interface structure. ACS Nano, 11(12), pp. 12049-12056. (doi: 10.1021/acsnano.7b04698) (PMID:29220155)

Ramakrishnan, Gopakumar, González-Jiménez, Mario ORCID logoORCID: https://orcid.org/0000-0002-8853-0588, Lapthorn, Adrian J. ORCID logoORCID: https://orcid.org/0000-0002-2197-8134 and Wynne, Klaas ORCID logoORCID: https://orcid.org/0000-0002-5305-5940 (2017) Spectrum of slow and super-slow (picosecond to nanosecond) water dynamics around organic and biological solutes. Journal of Physical Chemistry Letters, 8(13), pp. 2964-2970. (doi: 10.1021/acs.jpclett.7b01127) (PMID:28612605)

Paschke, Beth, Ahmed, Shazia, Milne, Sue and Lapthorn, Adrian ORCID logoORCID: https://orcid.org/0000-0002-2197-8134 (2017) Maths Support for Science: A Blended and Online Development Project. Horizons in STEM Higher Education Conference: Making Connections and Sharing Pedagogy, Edinburgh, Scotland, 29-30 Jun 2017.

2016

Berger, Peter and Lapthorn, Adrian J. ORCID logoORCID: https://orcid.org/0000-0002-2197-8134 (2016) The molecular relationship between antigenic domains and epitopes on hCG. Molecular Immunology, 76, pp. 134-145. (doi: 10.1016/j.molimm.2016.06.015) (PMID:27450517)

González-Jiminéz, Mario ORCID logoORCID: https://orcid.org/0000-0002-8853-0588, Ramakrishnan, Gopakumar, Harwood, Thomas, Lapthorn, Adrian J. ORCID logoORCID: https://orcid.org/0000-0002-2197-8134, Kelly, Sharon M. ORCID logoORCID: https://orcid.org/0000-0002-3516-1387, Ellis, Elizabeth M. and Wynne, Klaas ORCID logoORCID: https://orcid.org/0000-0002-5305-5940 (2016) Observation of coherent delocalized phonon-like modes in DNA under physiological conditions. Nature Communications, 7, 11799. (doi: 10.1038/ncomms11799) (PMID:27248361) (PMCID:PMC4895446)

Jack, C. et al. (2016) Spatial control of chemical processes on nanostructures through nano-localized water heating. Nature Communications, 7, 10946. (doi: 10.1038/ncomms10946) (PMID:26961708) (PMCID:PMC4792951)

Berger, Peter and Lapthorn, Adrian ORCID logoORCID: https://orcid.org/0000-0002-2197-8134 (2016) Standardization of Epitopes for human chorionic gonadotropin (hCG) Immunoassays. Current Medicinal Chemistry, 23(30), pp. 3481-3494. (doi: 10.2174/0929867323666160530145503) (PMID:27237818)

2015

Tullius, Ryan, Karimullah, Affar S. ORCID logoORCID: https://orcid.org/0000-0002-8792-9829, Rodier, Marion, Fitzpatrick, Brian, Gadegaard, Nikolaj ORCID logoORCID: https://orcid.org/0000-0002-3396-846X, Barron, Laurence D., Rotello, Vincent M., Cooke, Graeme ORCID logoORCID: https://orcid.org/0000-0003-0890-5720, Lapthorn, Adrian ORCID logoORCID: https://orcid.org/0000-0002-2197-8134 and Kadodwala, Malcolm ORCID logoORCID: https://orcid.org/0000-0003-4989-5688 (2015) "Superchiral” spectroscopy: detection of protein higher order hierarchical structure with chiral plasmonic nanostructures. Journal of the American Chemical Society, 137(26), pp. 8380-8383. (doi: 10.1021/jacs.5b04806) (PMID:26102606)

2014

Turton, David A., Senn, Hans ORCID logoORCID: https://orcid.org/0000-0001-8232-5957, Harwood, Thomas, Lapthorn, Adrian J. ORCID logoORCID: https://orcid.org/0000-0002-2197-8134, Ellis, Elizabeth M. and Wynne, Klaas ORCID logoORCID: https://orcid.org/0000-0002-5305-5940 (2014) Terahertz underdamped vibrational motion governs protein-ligand binding in solution. Nature Communications, 5, p. 3999. (doi: 10.1038/ncomms4999)

2013

Turton, David, Harwood, Thomas, Lapthorn, Adrian ORCID logoORCID: https://orcid.org/0000-0002-2197-8134, Ellis, Elizabeth and Wynne, Klaas ORCID logoORCID: https://orcid.org/0000-0002-5305-5940 (2013) Ultrabroadband terahertz spectroscopies of biomolecules and water. Proceedings of the SPIE: The International Society for Optical Engineering, 8623(862303), (doi: 10.1117/12.2003796)

Lapthorn, Adrian J. ORCID logoORCID: https://orcid.org/0000-0002-2197-8134, Zhu, Xiaofeng and Ellis, Elizabeth M. (2013) The diversity of microbial aldo/keto reductases from Escherichia coli K12. Chemico-Biological Interactions, 202(1-3), pp. 168-177. (doi: 10.1016/j.cbi.2012.10.008) (PMID:23103600)

2011

Paz, S. et al. (2011) Tetrahydrobenzothiophene derivatives: conformationally restricted inhibitors of type II dehydroquinase. ChemMedChem, 6(2), pp. 266-272. (doi: 10.1002/cmdc.201000343)

Tran, A.T., Cergol, K.M., West, N.P., Randall, E.J., Britton, W.J., Bokhari, S.A.I., Ibrahim, M., Lapthorn, A.J. ORCID logoORCID: https://orcid.org/0000-0002-2197-8134 and Payne, R.J. (2011) Synthesis and evaluation of potent ene-yne inhibitors of type II dehydroquinases as tuberculosis drug leads. ChemMedChem, 6(2), pp. 262-265. (doi: 10.1002/cmdc.201000399)

2010

Hendry, E., Carpy, T., Johnston, J., Popland, M., Mikhaylovskiy, R.V., Lapthorn, A. ORCID logoORCID: https://orcid.org/0000-0002-2197-8134, Kelly, S.M., Barron, L.D., Gadegaard, N. ORCID logoORCID: https://orcid.org/0000-0002-3396-846X and Kadodwala, M. ORCID logoORCID: https://orcid.org/0000-0003-4989-5688 (2010) Ultrasensitive detection and characterization of biomolecules using superchiral fields. Nature Nanotechnology, 5(11), pp. 783-787. (doi: 10.1038/nnano.2010.209)

Tran, A.T., Cergol, K.M., Britton, W.J., Bokhari, S.A.I., Ibrahim, M., Lapthorn, A.J. ORCID logoORCID: https://orcid.org/0000-0002-2197-8134 and Payne, R.J. (2010) Rapid assembly of potent type II dehydroquinase inhibitors via "Click" chemistry. MedChemComm, 1(4), pp. 271-275. (doi: 10.1039/c0md00097c)

2008

Dixon, D. P., Lapthorn, A. ORCID logoORCID: https://orcid.org/0000-0002-2197-8134, Madesis, P., Mudd, E. A., Day, A. and Edwards, R. (2008) Binding and glutathione conjugation of porphyrinogens by plant glutathione transferases. Journal of Biological Chemistry, 283(29), pp. 20268-20276. (doi: 10.1074/jbc.M802026200)

Stewart, K. A., Robinson, D. A. and Lapthorn, A. J. ORCID logoORCID: https://orcid.org/0000-0002-2197-8134 (2008) Type II dehydroquinase: molecular replacement with many copies. Acta Crystallographica. Section D: Biological Crystallography, 64, pp. 108-118. (doi: 10.1107/S0907444907054923)

2007

Payne, R.J., Riboldi-Tunnicliffe, A., Kerbarh, O., Abell, A.D., Lapthorn, A.J. ORCID logoORCID: https://orcid.org/0000-0002-2197-8134 and Abell, C. (2007) Design, synthesis, and structural studies on potent biaryl inhibitors of type II dehydroquinases. ChemMedChem, 2(7), pp. 1010-1013. (doi: 10.1002/cmdc.200700062)

Prazeres, Veronica F.V., Sanchez-Sixto, Cristina, Castedo, Luis, Lamb, Heather, Hawkins, Alistair R., Riboldi-Tunnicliffe, Alan, Coggins, John R., Lapthorn, Adrian J. ORCID logoORCID: https://orcid.org/0000-0002-2197-8134 and Gonzalez-Bello, Concepcion (2007) Nanomolar competitive inhibitors of Mycobacterium tuberculosis and Streptomyces coelicolor type II dehydroquinase. ChemMedChem, 2(2), pp. 194-207. (doi: 10.1002/cmdc.200600208)

2006

Lohkamp, B, Paterson, NG and Lapthorn, AJ ORCID logoORCID: https://orcid.org/0000-0002-2197-8134 (2006) Application of a new vector system for efficient protein purification in the crystallization of PA5104/ORF from Pseudomonas aeruginosa. Journal of Structural Biology, 155, pp. 111-113. (doi: 10.1016/j.jsb.2006.03.016)

Robinson, D.A,, Stewart, K.A., Price, N.C., Chalk, P.A., Coggins, J.R. and Lapthorn, A.J. ORCID logoORCID: https://orcid.org/0000-0002-2197-8134 (2006) Crystal structures of Helicobacter pylori type II dehydroquinase inhibitor complexes: new directions for inhibitor design. Journal of Medicinal Chemistry, 49(4), pp. 1282-1290. (doi: 10.1021/jm0505361)

Zhu, XF, Lapthorn, AJ ORCID logoORCID: https://orcid.org/0000-0002-2197-8134 and Ellis, EM (2006) Crystal structure of mouse succinic semialdehyde reductase AKR7A5: Structural basis for substrate specificity. Biochemistry, 45, pp. 1562-1570. (doi: 10.1021/bi051610k)

2005

Dias-Gunasekara, S., Gubbens, J., van Lith, M., Dunne, C., Williams, J.A.G., Kataky, R., Scoones, D., Lapthorn, A., Bulleid, N.J. ORCID logoORCID: https://orcid.org/0000-0002-9839-5279 and Benham, A.M. (2005) Tissue-specific expression and dimerization of the endoplasmic reticulum oxidoreductase Ero1β. Journal of Biological Chemistry, 280, pp. 33066-33075. (doi: 10.1074/jbc.M505023200)

Charrel-Dennis, M. et al. (2005) The human chorionic gonadotropin-beta arginine(68) to glutamic acid substitution fixes the conformation of the C-terminal peptide. Molecular Endocrinology, 19, pp. 1803-1811. (doi: 10.1210/me.2004-0109)

Dixon, DP, Lapthorn, AJ ORCID logoORCID: https://orcid.org/0000-0002-2197-8134 and Edwards, R (2005) Synthesis and analysis of chimeric maize glutathione transferases. Plant Science, 168, pp. 873-881. (doi: 10.1016/j.plantsci.2004.11.009)

Toscano, M.D., Stewart, K.A., Coggins, J.R., Lapthorn, A.J. ORCID logoORCID: https://orcid.org/0000-0002-2197-8134 and Abell, C. (2005) Rational design of new bifunctional inhibitors of type II dehydroquinase. Organic and Biomolecular Chemistry, 3, pp. 3102-3104. (doi: 10.1039/B507156A)

2004

Lohkamp, B., McDermott, G., Campbell, S.A., Coggins, J.R. and Lapthorn, A.J. ORCID logoORCID: https://orcid.org/0000-0002-2197-8134 (2004) The structure of Escherichia coli ATP-phosphoribosyltransferase: identification of substrate binding sites and mode of AMP inhibition. Journal of Molecular Biology, 336(1), pp. 131-144. (doi: 10.1016/j.jmb.2003.12.020)

Charrel-Dennis, M, Jackson, AM, Lund, T, Lapthorn, AJ ORCID logoORCID: https://orcid.org/0000-0002-2197-8134, Berger, P, Roitt, IM and Delves, PJ (2004) The major hormone-specific discontinuous epitopes on human chorionic gonadotrophin. Journal of Molecular Endocrinology, 32, pp. 571-581.

Frederickson, Martyn, Roszak, Aleksander W., Coggins, John R., Lapthorn, Adrian J. ORCID logoORCID: https://orcid.org/0000-0002-2197-8134 and Abell, Chris (2004) (1R,4S,5R)-3-Fluoro-1,4,5-trihydroxy-2-cyclohexene-1-carboxylic acid: the fluoro analogue of the enolate intermediate in the reaction catalyzed by type II dehydroquinases. Organic and Biomolecular Chemistry, 2(11), pp. 1592-1596. (doi: 10.1039/B404535A)

2003

Coggins, J.R., Abell, C., Evan, L.B., Frederickson, M., Robinson, D.A., Roszak, A.W. and Lapthorn, A.P. ORCID logoORCID: https://orcid.org/0000-0002-2197-8134 (2003) Experiences with the Shikimate-pathway enzymes as targets for rational drug design. Biochemical Society Transactions, 31(3), pp. 548-552.

Cerasoli, E., Kelly, S.M. ORCID logoORCID: https://orcid.org/0000-0002-3516-1387, Coggins, J.R., Lapthorn, A.J. ORCID logoORCID: https://orcid.org/0000-0002-2197-8134, Clarke, D.T. and Price, N.C. (2003) Effects of salts on the function and conformational stability of shikimate kinase. Biochimica et Biophysica Acta: Proteins and Proteomics, 1648(1-2), pp. 43-54. (doi: 10.1016/S1570-9639(03)00110-9)

Michel, G., Roszak, A.W., Sauve, V., Maclean, J., Matte, A., Coggins, J.R., Cygler, M. and Lapthorn, A.J. ORCID logoORCID: https://orcid.org/0000-0002-2197-8134 (2003) Structures of Shikimate dehydrogenase AroE and its paralog YdiB: a common structural framework for different activities. Journal of Biological Chemistry, 278, pp. 19463-19472. (doi: 10.1074/jbc.M300794200)

Dixon, DP, McEwen, AG, Lapthorn, AJ ORCID logoORCID: https://orcid.org/0000-0002-2197-8134 and Edwards, R (2003) Forced evolution of a herbicide detoxifying glutathione transferase. Journal of Biological Chemistry, 278, pp. 23930-23935. (doi: 10.1074/jbc.M303620200)

Kozma, E., Brown, E., Ellis, E.M. and Lapthorn, A.J. ORCID logoORCID: https://orcid.org/0000-0002-2197-8134 (2003) The high resolution crystal structure of rat liver AKR7A1: understanding the substrate specificites of the AKR7 family. Chemico-Biological Interactions, 143, pp. 289-297.

2002

Evans, Lewis D.B., Roszak, Aleksander W., Noble, Lorna J., Robinson, David A., Chalk, Peter A., Matthews, Jennifer L., Coggins, John R., Price, Nicholas C. and Lapthorn, Adrian J. ORCID logoORCID: https://orcid.org/0000-0002-2197-8134 (2002) Specificity of substrate recognition by type II dehydroquinases as revealed by binding of polyanions. FEBS Letters, 530(1-3), pp. 24-30. (doi: 10.1016/S0014-5793(02)03346-X)

Roszak, A.W., Robinson, D.A., Krell, T., Hunter, I.S., Fredrickson, M., Abell, C., Coggins, J.R. and Lapthorn, A.J. ORCID logoORCID: https://orcid.org/0000-0002-2197-8134 (2002) The structure and mechanism of the type II dehydroquinase from Streptomyces coelicolor. Structure, 10(4), pp. 493-503. (doi: 10.1016/S0969-2126(02)00747-5)

Dixon, David P., Lapthorn, Adrian ORCID logoORCID: https://orcid.org/0000-0002-2197-8134 and Edwards, Robert (2002) Plant glutathione transferases. Genome Biology, 3(3), reviews300. (doi: 10.1186/gb-2002-3-3-reviews3004) (PMID:11897031) (PMCID:PMC139027)

Kozma, E, Brown, E, Ellis, EM and Lapthorn, AJ ORCID logoORCID: https://orcid.org/0000-0002-2197-8134 (2002) The crystal structure of rat liver AKR7A1 - A dimeric member of the aldo-keto reductase superfamily. Journal of Biological Chemistry, 277, pp. 16285-16293. (doi: 10.1074/jbc.M110808200)

Thom, R, Cummins, I, Dixon, DP, Edwards, R, Cole, DJ and Lapthorn, AJ ORCID logoORCID: https://orcid.org/0000-0002-2197-8134 (2002) Structure of a tau class glutathione S-transferase from wheat active in herbicide detoxification. Biochemistry, 41, pp. 7008-7020. (doi: 10.1021/bi015964x)

2001

Krell, T., Maclean, J., Boam, D.J., Cooper, A., Resmini, M., Brocklehurst, K., Kelly, S.M., Price, N.C., Lapthorn, A.J. ORCID logoORCID: https://orcid.org/0000-0002-2197-8134 and Coggins, J.R. (2001) Biochemical and X-ray crystallographic studies on shikimate kinase: the important structural role of the P-loop lysine. Protein Science, 10(6), pp. 1137-1149. (doi: 10.1110/ps.52501)

Thom, R, Dixon, DP, Edwards, R, Cole, DJ and Lapthorn, AJ ORCID logoORCID: https://orcid.org/0000-0002-2197-8134 (2001) The structure of a zeta class glutathione S-transferase from Arabidopsis thaliana: Characterisation of a GST with novel active-site architecture and a putative role in tyrosine catabolism. Journal of Molecular Biology, 308, pp. 949-962. (doi: 10.1006/jmbi.2001.4638)

Thom, R., Dixon, D., Edwards, R., Cole, D. and Lapthorn, A. ORCID logoORCID: https://orcid.org/0000-0002-2197-8134 (2001) Structure determination of zeta class glutathione transferase from Arabidopsis thaliana. Chemico-Biological Interactions, 133, pp. 53-54.

2000

Maclean, John, Campbell, Samantha A., Pollock, Kevin, Chackrewarthy, Sureka, Coggins, John R. and Lapthorn, Adrian J. ORCID logoORCID: https://orcid.org/0000-0002-2197-8134 (2000) Crystallization and preliminary X-ray analysis of shikimate dehydrogenase fromEscherichia coli. Acta Crystallographica. Section D: Biological Crystallography, 56(4), pp. 512-515. (doi: 10.1107/S0907444900002377)

1998

Krell, Tino, Coggins, John R. and Lapthorn, Adrian J. ORCID logoORCID: https://orcid.org/0000-0002-2197-8134 (1998) The three-dimensional structure of shikimate kinase. Journal of Molecular Biology, 278(5), pp. 983-997. (doi: 10.1006/jmbi.1998.1755) (PMID:9600856)

1997

Idziak, Christopher, Price, Nicholas C., Kelly, Sharon M., Krell, Tino, Boam, Deborah J., Lapthorn, Adrian J. ORCID logoORCID: https://orcid.org/0000-0002-2197-8134 and Coggins, John R. (1997) 93 The interaction of shikimate kinase fromErwinia chrystanthemiwith substrates. Biochemical Society Transactions, 25(4), S627-S627. (doi: 10.1042/bst025s627)

Krell, T., Coyle, J. E., Horsburgh, M. J., Coggins, J. R. and Lapthorn, A. J. ORCID logoORCID: https://orcid.org/0000-0002-2197-8134 (1997) Crystallization and preliminary X-ray crystallographic analysis of shikimate kinase fromErwinia chrysanthemi. Acta Crystallographica. Section D: Biological Crystallography, 53(5), pp. 612-614. (doi: 10.1107/S0907444997004319)

1996

Berger, P. et al. (1996) Immunochemical mapping of gonadotropins. Molecular and Cellular Endocrinology, 125(1-2), pp. 33-43. (doi: 10.1016/S0303-7207(96)03943-3)

Bhowmick, N., Huang, J., Puett, D., Isaacs, N.W. and Lapthorn, A.J. ORCID logoORCID: https://orcid.org/0000-0002-2197-8134 (1996) Determination of residues important in hormone binding to the extracellular domain of the luteinizing hormone/chorionic gonadotropin receptor by site-directed mutagenesis and modeling. Molecular Endocrinology, 10(9), pp. 1147-1159. (doi: 10.1210/mend.10.9.8885249)

Jackson, Alison M., Klonisch, Thomas, Lapthorn, Adrian J. ORCID logoORCID: https://orcid.org/0000-0002-2197-8134, Berger, Peter, Isaacs, Neil W., Delves, Peter J., Lund, Torben and Roitt, Ivan M. (1996) Identification and selective destruction of shared epitopes in human chorionic gonadotropin beta subunit. Journal of Reproductive Immunology, 31(1-2), pp. 21-36. (doi: 10.1016/0165-0378(96)00978-3)

Klonisch, Thomas, Delves, Peter J., Berger, Peter, Panayotou, George, Lapthorn, Adrian J. ORCID logoORCID: https://orcid.org/0000-0002-2197-8134, Isaacs, Neil W., Wick, Georg, Lund, Torben and Roitt, Ivan M. (1996) Relative location of epitopes involved in synergistic antibody binding using human chorionic gonadotropin as a model. European Journal of Immunology, 26(8), pp. 1897-1905. (doi: 10.1002/eji.1830260834) (PMID:8765037)

1995

Lapthorn, A.J. ORCID logoORCID: https://orcid.org/0000-0002-2197-8134, Janes, Robert W., Isaacs, N.W. and Wallace, B.A. (1995) Cystine nooses and protein specificity. Nature Structural Biology, 2(4), pp. 266-268. (doi: 10.1038/nsb0495-266) (PMID:7796259)

1994

Lapthorn, A. J. ORCID logoORCID: https://orcid.org/0000-0002-2197-8134, Harris, D. C., Littlejohn, A., Lustbader, J. W., Canfield, R. E., Machin, K. J., Morgan, F. J. and Isaacs, N. W. (1994) Crystal structure of human chorionic gonadotropin. Nature, 369(6480), pp. 455-461. (doi: 10.1038/369455a0) (PMID:8202136)

1993

Guillet, V., Lapthorn, A. ORCID logoORCID: https://orcid.org/0000-0002-2197-8134, Hartley, R.W. and Mauguen, Y. (1993) Recognition between a bacterial ribonuclease, barnase, and its natural inhibitor, barstar. Structure, 1(3), pp. 165-176. (doi: 10.1016/0969-2126(93)90018-C) (PMID:16100951)

Guillet, Valéric, Lapthorn, Adrian ORCID logoORCID: https://orcid.org/0000-0002-2197-8134 and Mauguen, Yves (1993) Three-dimensional structure of a barnase-3'GMP complex at 2.2Å resolution. FEBS Letters, 330(2), pp. 137-140. (doi: 10.1016/0014-5793(93)80259-W) (PMID:8396045)

Guillet, Valérie, Lapthorn, Adrian ORCID logoORCID: https://orcid.org/0000-0002-2197-8134, Fourniat, Jacky, Benoit, Jean-Pierre, Hartley, Robert W. and Mauguen, Yves (1993) Crystallization and prelilminary X-ray investigation of barster, the intracellular inhibitor of barnase. Proteins, 17(3), pp. 325-328. (doi: 10.1002/prot.340170309) (PMID:8272429)

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Number of items: 61.

Articles

Cardwell, Patrick A., Del Moro, Carlo, Murphy, Michael P., Lapthorn, Adrian J. ORCID logoORCID: https://orcid.org/0000-0002-2197-8134 and Hartley, Richard C. ORCID logoORCID: https://orcid.org/0000-0003-1033-5405 (2024) Human mitochondrial glutathione transferases: Kinetic parameters and accommodation of a mitochondria-targeting group in substrates. Bioorganic and Medicinal Chemistry, 104, 117712. (doi: 10.1016/j.bmc.2024.117712) (PMID:38593670)

Wallace, S. et al. (2023) Multiplexed biosensing of proteins and virions with disposable plasmonic assays. ACS Sensors, 8(9), pp. 3338-3348. (doi: 10.1021/acssensors.2c02238) (PMID:37610841) (PMCID:PMC10521139)

Kakkar, T. et al. (2020) Superchiral near fields detect virus structure. Light: Science and Applications, 9(1), 195. (doi: 10.1038/s41377-020-00433-1) (PMID:33298854) (PMCID:PMC7705013)

Rodier, Marion, Keijzer, Chantal, Milner, Joel ORCID logoORCID: https://orcid.org/0000-0003-3702-4295, Karimullah, Affar Shahid ORCID logoORCID: https://orcid.org/0000-0002-8792-9829, Barron, Laurence, Gadegaard, Nikolaj ORCID logoORCID: https://orcid.org/0000-0002-3396-846X, Lapthorn, Adrian J. ORCID logoORCID: https://orcid.org/0000-0002-2197-8134 and Kadodwala, Malcolm ORCID logoORCID: https://orcid.org/0000-0003-4989-5688 (2020) Biomacromolecular charge chirality detected using chiral plasmonic nanostructures. Nanoscale Horizons, 5, pp. 336-344. (doi: 10.1039/C9NH00525K)

Rodier, Marion, Keijzer, Chantal, Milner, Joel ORCID logoORCID: https://orcid.org/0000-0003-3702-4295, Karimullah, Affar ORCID logoORCID: https://orcid.org/0000-0002-8792-9829, Barron, Laurence, Gadegaard, Nikolaj ORCID logoORCID: https://orcid.org/0000-0002-3396-846X, Lapthorn, Adrian ORCID logoORCID: https://orcid.org/0000-0002-2197-8134 and Kadodwala, Malcolm ORCID logoORCID: https://orcid.org/0000-0003-4989-5688 (2019) Probing specificity of protein-protein interactions with chiral plasmonic nanostructures. Journal of Physical Chemistry Letters, 10, pp. 6105-6111. (doi: 10.1021/acs.jpclett.9b02288) (PMID:31549842)

Kelly, Christopher, Tullius, Ryan, Lapthorn, Adrian J. ORCID logoORCID: https://orcid.org/0000-0002-2197-8134, Gadegaard, Nikolaj ORCID logoORCID: https://orcid.org/0000-0002-3396-846X, Cooke, Graeme ORCID logoORCID: https://orcid.org/0000-0003-0890-5720, Barron, Laurence D., Karimullah, Affar S. ORCID logoORCID: https://orcid.org/0000-0002-8792-9829, Rotello, Vincent M. and Kadodwala, Malcolm ORCID logoORCID: https://orcid.org/0000-0003-4989-5688 (2018) Chiral plasmonic fields probe structural order of biointerfaces. Journal of the American Chemical Society, 140(27), pp. 8509-8517. (doi: 10.1021/jacs.8b03634) (PMID:29909628)

Tullius, R. et al. (2017) Superchiral plasmonic phase sensitivity for fingerprinting of protein interface structure. ACS Nano, 11(12), pp. 12049-12056. (doi: 10.1021/acsnano.7b04698) (PMID:29220155)

Ramakrishnan, Gopakumar, González-Jiménez, Mario ORCID logoORCID: https://orcid.org/0000-0002-8853-0588, Lapthorn, Adrian J. ORCID logoORCID: https://orcid.org/0000-0002-2197-8134 and Wynne, Klaas ORCID logoORCID: https://orcid.org/0000-0002-5305-5940 (2017) Spectrum of slow and super-slow (picosecond to nanosecond) water dynamics around organic and biological solutes. Journal of Physical Chemistry Letters, 8(13), pp. 2964-2970. (doi: 10.1021/acs.jpclett.7b01127) (PMID:28612605)

Berger, Peter and Lapthorn, Adrian J. ORCID logoORCID: https://orcid.org/0000-0002-2197-8134 (2016) The molecular relationship between antigenic domains and epitopes on hCG. Molecular Immunology, 76, pp. 134-145. (doi: 10.1016/j.molimm.2016.06.015) (PMID:27450517)

González-Jiminéz, Mario ORCID logoORCID: https://orcid.org/0000-0002-8853-0588, Ramakrishnan, Gopakumar, Harwood, Thomas, Lapthorn, Adrian J. ORCID logoORCID: https://orcid.org/0000-0002-2197-8134, Kelly, Sharon M. ORCID logoORCID: https://orcid.org/0000-0002-3516-1387, Ellis, Elizabeth M. and Wynne, Klaas ORCID logoORCID: https://orcid.org/0000-0002-5305-5940 (2016) Observation of coherent delocalized phonon-like modes in DNA under physiological conditions. Nature Communications, 7, 11799. (doi: 10.1038/ncomms11799) (PMID:27248361) (PMCID:PMC4895446)

Jack, C. et al. (2016) Spatial control of chemical processes on nanostructures through nano-localized water heating. Nature Communications, 7, 10946. (doi: 10.1038/ncomms10946) (PMID:26961708) (PMCID:PMC4792951)

Berger, Peter and Lapthorn, Adrian ORCID logoORCID: https://orcid.org/0000-0002-2197-8134 (2016) Standardization of Epitopes for human chorionic gonadotropin (hCG) Immunoassays. Current Medicinal Chemistry, 23(30), pp. 3481-3494. (doi: 10.2174/0929867323666160530145503) (PMID:27237818)

Tullius, Ryan, Karimullah, Affar S. ORCID logoORCID: https://orcid.org/0000-0002-8792-9829, Rodier, Marion, Fitzpatrick, Brian, Gadegaard, Nikolaj ORCID logoORCID: https://orcid.org/0000-0002-3396-846X, Barron, Laurence D., Rotello, Vincent M., Cooke, Graeme ORCID logoORCID: https://orcid.org/0000-0003-0890-5720, Lapthorn, Adrian ORCID logoORCID: https://orcid.org/0000-0002-2197-8134 and Kadodwala, Malcolm ORCID logoORCID: https://orcid.org/0000-0003-4989-5688 (2015) "Superchiral” spectroscopy: detection of protein higher order hierarchical structure with chiral plasmonic nanostructures. Journal of the American Chemical Society, 137(26), pp. 8380-8383. (doi: 10.1021/jacs.5b04806) (PMID:26102606)

Turton, David A., Senn, Hans ORCID logoORCID: https://orcid.org/0000-0001-8232-5957, Harwood, Thomas, Lapthorn, Adrian J. ORCID logoORCID: https://orcid.org/0000-0002-2197-8134, Ellis, Elizabeth M. and Wynne, Klaas ORCID logoORCID: https://orcid.org/0000-0002-5305-5940 (2014) Terahertz underdamped vibrational motion governs protein-ligand binding in solution. Nature Communications, 5, p. 3999. (doi: 10.1038/ncomms4999)

Turton, David, Harwood, Thomas, Lapthorn, Adrian ORCID logoORCID: https://orcid.org/0000-0002-2197-8134, Ellis, Elizabeth and Wynne, Klaas ORCID logoORCID: https://orcid.org/0000-0002-5305-5940 (2013) Ultrabroadband terahertz spectroscopies of biomolecules and water. Proceedings of the SPIE: The International Society for Optical Engineering, 8623(862303), (doi: 10.1117/12.2003796)

Lapthorn, Adrian J. ORCID logoORCID: https://orcid.org/0000-0002-2197-8134, Zhu, Xiaofeng and Ellis, Elizabeth M. (2013) The diversity of microbial aldo/keto reductases from Escherichia coli K12. Chemico-Biological Interactions, 202(1-3), pp. 168-177. (doi: 10.1016/j.cbi.2012.10.008) (PMID:23103600)

Paz, S. et al. (2011) Tetrahydrobenzothiophene derivatives: conformationally restricted inhibitors of type II dehydroquinase. ChemMedChem, 6(2), pp. 266-272. (doi: 10.1002/cmdc.201000343)

Tran, A.T., Cergol, K.M., West, N.P., Randall, E.J., Britton, W.J., Bokhari, S.A.I., Ibrahim, M., Lapthorn, A.J. ORCID logoORCID: https://orcid.org/0000-0002-2197-8134 and Payne, R.J. (2011) Synthesis and evaluation of potent ene-yne inhibitors of type II dehydroquinases as tuberculosis drug leads. ChemMedChem, 6(2), pp. 262-265. (doi: 10.1002/cmdc.201000399)

Hendry, E., Carpy, T., Johnston, J., Popland, M., Mikhaylovskiy, R.V., Lapthorn, A. ORCID logoORCID: https://orcid.org/0000-0002-2197-8134, Kelly, S.M., Barron, L.D., Gadegaard, N. ORCID logoORCID: https://orcid.org/0000-0002-3396-846X and Kadodwala, M. ORCID logoORCID: https://orcid.org/0000-0003-4989-5688 (2010) Ultrasensitive detection and characterization of biomolecules using superchiral fields. Nature Nanotechnology, 5(11), pp. 783-787. (doi: 10.1038/nnano.2010.209)

Tran, A.T., Cergol, K.M., Britton, W.J., Bokhari, S.A.I., Ibrahim, M., Lapthorn, A.J. ORCID logoORCID: https://orcid.org/0000-0002-2197-8134 and Payne, R.J. (2010) Rapid assembly of potent type II dehydroquinase inhibitors via "Click" chemistry. MedChemComm, 1(4), pp. 271-275. (doi: 10.1039/c0md00097c)

Dixon, D. P., Lapthorn, A. ORCID logoORCID: https://orcid.org/0000-0002-2197-8134, Madesis, P., Mudd, E. A., Day, A. and Edwards, R. (2008) Binding and glutathione conjugation of porphyrinogens by plant glutathione transferases. Journal of Biological Chemistry, 283(29), pp. 20268-20276. (doi: 10.1074/jbc.M802026200)

Stewart, K. A., Robinson, D. A. and Lapthorn, A. J. ORCID logoORCID: https://orcid.org/0000-0002-2197-8134 (2008) Type II dehydroquinase: molecular replacement with many copies. Acta Crystallographica. Section D: Biological Crystallography, 64, pp. 108-118. (doi: 10.1107/S0907444907054923)

Payne, R.J., Riboldi-Tunnicliffe, A., Kerbarh, O., Abell, A.D., Lapthorn, A.J. ORCID logoORCID: https://orcid.org/0000-0002-2197-8134 and Abell, C. (2007) Design, synthesis, and structural studies on potent biaryl inhibitors of type II dehydroquinases. ChemMedChem, 2(7), pp. 1010-1013. (doi: 10.1002/cmdc.200700062)

Prazeres, Veronica F.V., Sanchez-Sixto, Cristina, Castedo, Luis, Lamb, Heather, Hawkins, Alistair R., Riboldi-Tunnicliffe, Alan, Coggins, John R., Lapthorn, Adrian J. ORCID logoORCID: https://orcid.org/0000-0002-2197-8134 and Gonzalez-Bello, Concepcion (2007) Nanomolar competitive inhibitors of Mycobacterium tuberculosis and Streptomyces coelicolor type II dehydroquinase. ChemMedChem, 2(2), pp. 194-207. (doi: 10.1002/cmdc.200600208)

Lohkamp, B, Paterson, NG and Lapthorn, AJ ORCID logoORCID: https://orcid.org/0000-0002-2197-8134 (2006) Application of a new vector system for efficient protein purification in the crystallization of PA5104/ORF from Pseudomonas aeruginosa. Journal of Structural Biology, 155, pp. 111-113. (doi: 10.1016/j.jsb.2006.03.016)

Robinson, D.A,, Stewart, K.A., Price, N.C., Chalk, P.A., Coggins, J.R. and Lapthorn, A.J. ORCID logoORCID: https://orcid.org/0000-0002-2197-8134 (2006) Crystal structures of Helicobacter pylori type II dehydroquinase inhibitor complexes: new directions for inhibitor design. Journal of Medicinal Chemistry, 49(4), pp. 1282-1290. (doi: 10.1021/jm0505361)

Zhu, XF, Lapthorn, AJ ORCID logoORCID: https://orcid.org/0000-0002-2197-8134 and Ellis, EM (2006) Crystal structure of mouse succinic semialdehyde reductase AKR7A5: Structural basis for substrate specificity. Biochemistry, 45, pp. 1562-1570. (doi: 10.1021/bi051610k)

Dias-Gunasekara, S., Gubbens, J., van Lith, M., Dunne, C., Williams, J.A.G., Kataky, R., Scoones, D., Lapthorn, A., Bulleid, N.J. ORCID logoORCID: https://orcid.org/0000-0002-9839-5279 and Benham, A.M. (2005) Tissue-specific expression and dimerization of the endoplasmic reticulum oxidoreductase Ero1β. Journal of Biological Chemistry, 280, pp. 33066-33075. (doi: 10.1074/jbc.M505023200)

Charrel-Dennis, M. et al. (2005) The human chorionic gonadotropin-beta arginine(68) to glutamic acid substitution fixes the conformation of the C-terminal peptide. Molecular Endocrinology, 19, pp. 1803-1811. (doi: 10.1210/me.2004-0109)

Dixon, DP, Lapthorn, AJ ORCID logoORCID: https://orcid.org/0000-0002-2197-8134 and Edwards, R (2005) Synthesis and analysis of chimeric maize glutathione transferases. Plant Science, 168, pp. 873-881. (doi: 10.1016/j.plantsci.2004.11.009)

Toscano, M.D., Stewart, K.A., Coggins, J.R., Lapthorn, A.J. ORCID logoORCID: https://orcid.org/0000-0002-2197-8134 and Abell, C. (2005) Rational design of new bifunctional inhibitors of type II dehydroquinase. Organic and Biomolecular Chemistry, 3, pp. 3102-3104. (doi: 10.1039/B507156A)

Lohkamp, B., McDermott, G., Campbell, S.A., Coggins, J.R. and Lapthorn, A.J. ORCID logoORCID: https://orcid.org/0000-0002-2197-8134 (2004) The structure of Escherichia coli ATP-phosphoribosyltransferase: identification of substrate binding sites and mode of AMP inhibition. Journal of Molecular Biology, 336(1), pp. 131-144. (doi: 10.1016/j.jmb.2003.12.020)

Charrel-Dennis, M, Jackson, AM, Lund, T, Lapthorn, AJ ORCID logoORCID: https://orcid.org/0000-0002-2197-8134, Berger, P, Roitt, IM and Delves, PJ (2004) The major hormone-specific discontinuous epitopes on human chorionic gonadotrophin. Journal of Molecular Endocrinology, 32, pp. 571-581.

Frederickson, Martyn, Roszak, Aleksander W., Coggins, John R., Lapthorn, Adrian J. ORCID logoORCID: https://orcid.org/0000-0002-2197-8134 and Abell, Chris (2004) (1R,4S,5R)-3-Fluoro-1,4,5-trihydroxy-2-cyclohexene-1-carboxylic acid: the fluoro analogue of the enolate intermediate in the reaction catalyzed by type II dehydroquinases. Organic and Biomolecular Chemistry, 2(11), pp. 1592-1596. (doi: 10.1039/B404535A)

Coggins, J.R., Abell, C., Evan, L.B., Frederickson, M., Robinson, D.A., Roszak, A.W. and Lapthorn, A.P. ORCID logoORCID: https://orcid.org/0000-0002-2197-8134 (2003) Experiences with the Shikimate-pathway enzymes as targets for rational drug design. Biochemical Society Transactions, 31(3), pp. 548-552.

Cerasoli, E., Kelly, S.M. ORCID logoORCID: https://orcid.org/0000-0002-3516-1387, Coggins, J.R., Lapthorn, A.J. ORCID logoORCID: https://orcid.org/0000-0002-2197-8134, Clarke, D.T. and Price, N.C. (2003) Effects of salts on the function and conformational stability of shikimate kinase. Biochimica et Biophysica Acta: Proteins and Proteomics, 1648(1-2), pp. 43-54. (doi: 10.1016/S1570-9639(03)00110-9)

Michel, G., Roszak, A.W., Sauve, V., Maclean, J., Matte, A., Coggins, J.R., Cygler, M. and Lapthorn, A.J. ORCID logoORCID: https://orcid.org/0000-0002-2197-8134 (2003) Structures of Shikimate dehydrogenase AroE and its paralog YdiB: a common structural framework for different activities. Journal of Biological Chemistry, 278, pp. 19463-19472. (doi: 10.1074/jbc.M300794200)

Dixon, DP, McEwen, AG, Lapthorn, AJ ORCID logoORCID: https://orcid.org/0000-0002-2197-8134 and Edwards, R (2003) Forced evolution of a herbicide detoxifying glutathione transferase. Journal of Biological Chemistry, 278, pp. 23930-23935. (doi: 10.1074/jbc.M303620200)

Kozma, E., Brown, E., Ellis, E.M. and Lapthorn, A.J. ORCID logoORCID: https://orcid.org/0000-0002-2197-8134 (2003) The high resolution crystal structure of rat liver AKR7A1: understanding the substrate specificites of the AKR7 family. Chemico-Biological Interactions, 143, pp. 289-297.

Evans, Lewis D.B., Roszak, Aleksander W., Noble, Lorna J., Robinson, David A., Chalk, Peter A., Matthews, Jennifer L., Coggins, John R., Price, Nicholas C. and Lapthorn, Adrian J. ORCID logoORCID: https://orcid.org/0000-0002-2197-8134 (2002) Specificity of substrate recognition by type II dehydroquinases as revealed by binding of polyanions. FEBS Letters, 530(1-3), pp. 24-30. (doi: 10.1016/S0014-5793(02)03346-X)

Roszak, A.W., Robinson, D.A., Krell, T., Hunter, I.S., Fredrickson, M., Abell, C., Coggins, J.R. and Lapthorn, A.J. ORCID logoORCID: https://orcid.org/0000-0002-2197-8134 (2002) The structure and mechanism of the type II dehydroquinase from Streptomyces coelicolor. Structure, 10(4), pp. 493-503. (doi: 10.1016/S0969-2126(02)00747-5)

Dixon, David P., Lapthorn, Adrian ORCID logoORCID: https://orcid.org/0000-0002-2197-8134 and Edwards, Robert (2002) Plant glutathione transferases. Genome Biology, 3(3), reviews300. (doi: 10.1186/gb-2002-3-3-reviews3004) (PMID:11897031) (PMCID:PMC139027)

Kozma, E, Brown, E, Ellis, EM and Lapthorn, AJ ORCID logoORCID: https://orcid.org/0000-0002-2197-8134 (2002) The crystal structure of rat liver AKR7A1 - A dimeric member of the aldo-keto reductase superfamily. Journal of Biological Chemistry, 277, pp. 16285-16293. (doi: 10.1074/jbc.M110808200)

Thom, R, Cummins, I, Dixon, DP, Edwards, R, Cole, DJ and Lapthorn, AJ ORCID logoORCID: https://orcid.org/0000-0002-2197-8134 (2002) Structure of a tau class glutathione S-transferase from wheat active in herbicide detoxification. Biochemistry, 41, pp. 7008-7020. (doi: 10.1021/bi015964x)

Krell, T., Maclean, J., Boam, D.J., Cooper, A., Resmini, M., Brocklehurst, K., Kelly, S.M., Price, N.C., Lapthorn, A.J. ORCID logoORCID: https://orcid.org/0000-0002-2197-8134 and Coggins, J.R. (2001) Biochemical and X-ray crystallographic studies on shikimate kinase: the important structural role of the P-loop lysine. Protein Science, 10(6), pp. 1137-1149. (doi: 10.1110/ps.52501)

Thom, R, Dixon, DP, Edwards, R, Cole, DJ and Lapthorn, AJ ORCID logoORCID: https://orcid.org/0000-0002-2197-8134 (2001) The structure of a zeta class glutathione S-transferase from Arabidopsis thaliana: Characterisation of a GST with novel active-site architecture and a putative role in tyrosine catabolism. Journal of Molecular Biology, 308, pp. 949-962. (doi: 10.1006/jmbi.2001.4638)

Thom, R., Dixon, D., Edwards, R., Cole, D. and Lapthorn, A. ORCID logoORCID: https://orcid.org/0000-0002-2197-8134 (2001) Structure determination of zeta class glutathione transferase from Arabidopsis thaliana. Chemico-Biological Interactions, 133, pp. 53-54.

Maclean, John, Campbell, Samantha A., Pollock, Kevin, Chackrewarthy, Sureka, Coggins, John R. and Lapthorn, Adrian J. ORCID logoORCID: https://orcid.org/0000-0002-2197-8134 (2000) Crystallization and preliminary X-ray analysis of shikimate dehydrogenase fromEscherichia coli. Acta Crystallographica. Section D: Biological Crystallography, 56(4), pp. 512-515. (doi: 10.1107/S0907444900002377)

Krell, Tino, Coggins, John R. and Lapthorn, Adrian J. ORCID logoORCID: https://orcid.org/0000-0002-2197-8134 (1998) The three-dimensional structure of shikimate kinase. Journal of Molecular Biology, 278(5), pp. 983-997. (doi: 10.1006/jmbi.1998.1755) (PMID:9600856)

Idziak, Christopher, Price, Nicholas C., Kelly, Sharon M., Krell, Tino, Boam, Deborah J., Lapthorn, Adrian J. ORCID logoORCID: https://orcid.org/0000-0002-2197-8134 and Coggins, John R. (1997) 93 The interaction of shikimate kinase fromErwinia chrystanthemiwith substrates. Biochemical Society Transactions, 25(4), S627-S627. (doi: 10.1042/bst025s627)

Krell, T., Coyle, J. E., Horsburgh, M. J., Coggins, J. R. and Lapthorn, A. J. ORCID logoORCID: https://orcid.org/0000-0002-2197-8134 (1997) Crystallization and preliminary X-ray crystallographic analysis of shikimate kinase fromErwinia chrysanthemi. Acta Crystallographica. Section D: Biological Crystallography, 53(5), pp. 612-614. (doi: 10.1107/S0907444997004319)

Berger, P. et al. (1996) Immunochemical mapping of gonadotropins. Molecular and Cellular Endocrinology, 125(1-2), pp. 33-43. (doi: 10.1016/S0303-7207(96)03943-3)

Bhowmick, N., Huang, J., Puett, D., Isaacs, N.W. and Lapthorn, A.J. ORCID logoORCID: https://orcid.org/0000-0002-2197-8134 (1996) Determination of residues important in hormone binding to the extracellular domain of the luteinizing hormone/chorionic gonadotropin receptor by site-directed mutagenesis and modeling. Molecular Endocrinology, 10(9), pp. 1147-1159. (doi: 10.1210/mend.10.9.8885249)

Jackson, Alison M., Klonisch, Thomas, Lapthorn, Adrian J. ORCID logoORCID: https://orcid.org/0000-0002-2197-8134, Berger, Peter, Isaacs, Neil W., Delves, Peter J., Lund, Torben and Roitt, Ivan M. (1996) Identification and selective destruction of shared epitopes in human chorionic gonadotropin beta subunit. Journal of Reproductive Immunology, 31(1-2), pp. 21-36. (doi: 10.1016/0165-0378(96)00978-3)

Klonisch, Thomas, Delves, Peter J., Berger, Peter, Panayotou, George, Lapthorn, Adrian J. ORCID logoORCID: https://orcid.org/0000-0002-2197-8134, Isaacs, Neil W., Wick, Georg, Lund, Torben and Roitt, Ivan M. (1996) Relative location of epitopes involved in synergistic antibody binding using human chorionic gonadotropin as a model. European Journal of Immunology, 26(8), pp. 1897-1905. (doi: 10.1002/eji.1830260834) (PMID:8765037)

Lapthorn, A.J. ORCID logoORCID: https://orcid.org/0000-0002-2197-8134, Janes, Robert W., Isaacs, N.W. and Wallace, B.A. (1995) Cystine nooses and protein specificity. Nature Structural Biology, 2(4), pp. 266-268. (doi: 10.1038/nsb0495-266) (PMID:7796259)

Lapthorn, A. J. ORCID logoORCID: https://orcid.org/0000-0002-2197-8134, Harris, D. C., Littlejohn, A., Lustbader, J. W., Canfield, R. E., Machin, K. J., Morgan, F. J. and Isaacs, N. W. (1994) Crystal structure of human chorionic gonadotropin. Nature, 369(6480), pp. 455-461. (doi: 10.1038/369455a0) (PMID:8202136)

Guillet, V., Lapthorn, A. ORCID logoORCID: https://orcid.org/0000-0002-2197-8134, Hartley, R.W. and Mauguen, Y. (1993) Recognition between a bacterial ribonuclease, barnase, and its natural inhibitor, barstar. Structure, 1(3), pp. 165-176. (doi: 10.1016/0969-2126(93)90018-C) (PMID:16100951)

Guillet, Valéric, Lapthorn, Adrian ORCID logoORCID: https://orcid.org/0000-0002-2197-8134 and Mauguen, Yves (1993) Three-dimensional structure of a barnase-3'GMP complex at 2.2Å resolution. FEBS Letters, 330(2), pp. 137-140. (doi: 10.1016/0014-5793(93)80259-W) (PMID:8396045)

Guillet, Valérie, Lapthorn, Adrian ORCID logoORCID: https://orcid.org/0000-0002-2197-8134, Fourniat, Jacky, Benoit, Jean-Pierre, Hartley, Robert W. and Mauguen, Yves (1993) Crystallization and prelilminary X-ray investigation of barster, the intracellular inhibitor of barnase. Proteins, 17(3), pp. 325-328. (doi: 10.1002/prot.340170309) (PMID:8272429)

Conference or Workshop Item

Paschke, Beth, Ahmed, Shazia, Milne, Sue and Lapthorn, Adrian ORCID logoORCID: https://orcid.org/0000-0002-2197-8134 (2017) Maths Support for Science: A Blended and Online Development Project. Horizons in STEM Higher Education Conference: Making Connections and Sharing Pedagogy, Edinburgh, Scotland, 29-30 Jun 2017.

This list was generated on Sun Jun 15 16:47:09 2025 BST.

Teaching

Teaching

Science Fundamentals:- Aqueous Solutions Science Fundamentals:- Reaction Kinetics
Level-1 Chemistry:- Attractions and Repulsions
Level-3 Chemistry:- Biophysical Chemistry

Research datasets

Jump to: 2024 | 2016
Number of items: 2.

2024

Cardwell, P. A., Del Moro, C., Murphy, M. P., Lapthorn, A. J. and Hartley, R. C. (2024) Human mitochondrial glutathione transferases: kinetic parameters and accommodation of a mitochondria-targeting group in substrates. [Data Collection]

2016

Gonzalez-Jimenez, M., Ramakrishnan, G., Harwood, T., Lapthorn, A. , Kelly, S. , Ellis, E. and Wynne, K. (2016) Observation of coherent delocalised phonon-like modes in DNA under physiological conditions. [Data Collection]

This list was generated on Sun Jun 15 07:43:30 2025 BST.

Additional information

Awards

PhD (York)