Dr Karla Neves

  • Honorary Research Fellow (School of Cardiovascular & Metabolic Health)

Biography

Bachelor’s degree in nursing from the Federal University of Mato Grosso, Brazil (2009). Master's Degree in Sciences from the FCFRP-USP Pharmaceutical Sciences program at the University of São Paulo-USP, Ribeirao Preto, Brazil (2012). Doctorate Degree in Sciences in the same University program. During PhD, I developed one-year training at the British Heart Foundation (BHF) at the University of Glasgow in Prof. Rhian Touyz`s lab and I am currently a Research Associate at the Institute of Cardiovascular and Medical Sciences - University of Glasgow. 

Research interests

Currently working on the vascular and molecular mechanisms by which VEGF inhibitors cause cardiovascular toxicities, focusing mainly on the role of microparticles, NAD(P)H oxidases and the antioxidant system. We are also interested in elucidating how a Notch3 mutation in CADASIL affects peripheral small vessels causing vascular dysfunction.

Publications

List by: Type | Date

Jump to: 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2012
Number of items: 41.

2023

Neves, Karla B. ORCID logoORCID: https://orcid.org/0000-0001-5158-9263, Rios, Francisco J. ORCID logoORCID: https://orcid.org/0000-0002-8194-0787, Sevilla-Montero, Javier, Montezano, Augusto C. and Touyz, Rhian M. ORCID logoORCID: https://orcid.org/0000-0003-0670-0887 (2023) Exosomes and the cardiovascular system: role in cardiovascular health and disease. Journal of Physiology, 601(22), pp. 4923-4936. (doi: 10.1113/JP282054) (PMID:35306667) (PMCID:PMC10953460)

Montezano, A. C. et al. (2023) SARS-CoV-2 spike protein induces endothelial inflammation via ACE2 independently of viral replication. Scientific Reports, 13, 14086. (doi: 10.1038/s41598-023-41115-3) (PMID:37640791) (PMCID:PMC10462711)

Morris, Hannah E., Neves, Karla B. ORCID logoORCID: https://orcid.org/0000-0001-5158-9263, Nilsen, Margaret, Montezano, Augusto C., MacLean, Margaret R. and Touyz, Rhian M. ORCID logoORCID: https://orcid.org/0000-0003-0670-0887 (2023) Notch3/Hes5 induces vascular dysfunction in hypoxia-induced pulmonary hypertension through ER stress and redox-sensitive pathways. Hypertension, 80(8), pp. 1683-1696. (doi: 10.1161/hypertensionaha.122.20449) (PMID:37254738)

Sykes, R. A. et al. (2023) Vascular mechanisms of post-COVID-19 conditions: rho-kinase is a novel target for therapy. European Heart Journal: Cardiovascular Pharmacotherapy, 9(4), pp. 371-386. (doi: 10.1093/ehjcvp/pvad025) (PMID:37019821) (PMCID:PMC10236521)

Neves, Karla B. ORCID logoORCID: https://orcid.org/0000-0001-5158-9263, Alves‐Lopes, Rheure ORCID logoORCID: https://orcid.org/0000-0002-4885-6647, Montezano, Augusto C. and Touyz, Rhian M. ORCID logoORCID: https://orcid.org/0000-0003-0670-0887 (2023) Role of PARP and TRPM2 in VEGF inhibitor‐induced vascular dysfunction. Journal of the American Heart Association, 12(4), e027769. (doi: 10.1161/JAHA.122.027769) (PMID:36802924) (PMCID:PMC10111475)

2022

Rios, F. J. et al. (2022) TRPM7 deficiency exacerbates cardiovascular and renal damage induced by aldosterone-salt. Communications Biology, 5, 746. (doi: 10.1038/s42003-022-03715-z) (PMID:35882956) (PMCID:PMC9325869)

Mirabito Colafella, K. M. et al. (2022) Differential effects of cyclo-oxygenase 1 and 2 inhibition on angiogenesis inhibitor-induced hypertension and kidney damage. Clinical Science, 136(9), pp. 675-694. (doi: 10.1042/CS20220182) (PMID:35441670) (PMCID:PMC9093150)

Camargo, L. L. et al. (2022) Central role of c-Src in NOX5- mediated redox signaling in vascular smooth muscle cells in human hypertension. Cardiovascular Research, 118(5), pp. 1359-1373. (doi: 10.1093/cvr/cvab171) (PMID:34320175) (PMCID:PMC8953456)

2021

Alves-Lopes, R. et al. (2021) Selective inhibition of the C-domain of ACE (angiotensin-converting enzyme) combined with inhibition of NEP (neprilysin): a potential new therapy for hypertension. Hypertension, 78(3), pp. 604-616. (doi: 10.1161/HYPERTENSIONAHA.121.17041) (PMID:34304582) (PMCID:PMC8357049)

Da Silva, J. F. et al. (2021) Lysophosphatidylcholine induces oxidative stress in human endothelial cells via NOX5 activation - implications in atherosclerosis. Clinical Science, 135(15), pp. 1845-1858. (doi: 10.1042/CS20210468) (PMID:34269800)

van Dorst, Daan C.H., Dobbin, Stephen J.H. ORCID logoORCID: https://orcid.org/0000-0002-9111-0242, Neves, Karla B. ORCID logoORCID: https://orcid.org/0000-0001-5158-9263, Herrmann, Joerg, Herrmann, Sandra M., Versmissen, Jorie, Mathijssen, Ron H.J., Danser, A.H. Jan and Lang, Ninian N. ORCID logoORCID: https://orcid.org/0000-0001-8441-6887 (2021) Hypertension and prohypertensive antineoplastic therapies in cancer patients. Circulation Research, 128(7), pp. 1040-1061. (doi: 10.1161/CIRCRESAHA.121.318051) (PMID:33793337) (PMCID:PMC8011349)

Cameron, Alan C., Neves, Karla B. ORCID logoORCID: https://orcid.org/0000-0001-5158-9263, White, Jeff, Touyz, Rhian M. ORCID logoORCID: https://orcid.org/0000-0003-0670-0887 and Lang, Ninian N. ORCID logoORCID: https://orcid.org/0000-0001-8441-6887 (2021) Reply: Cisplatin-associated aortic thrombosis: a review of cases reported to the FDA adverse event reporting system. JACC: CardioOncology, 3(1), p. 166. (doi: 10.1016/j.jaccao.2021.01.005)

Neves, Karla B. ORCID logoORCID: https://orcid.org/0000-0001-5158-9263, Morris, Hannah, Alves-Lopes, Rhéure, Muir, Keith W. ORCID logoORCID: https://orcid.org/0000-0001-9535-022X, Moreton, Fiona, Delles, Christian ORCID logoORCID: https://orcid.org/0000-0003-2238-2612, Montezano, Augusto C. and Touyz, Rhian M. ORCID logoORCID: https://orcid.org/0000-0003-0670-0887 (2021) Peripheral arteriopathy caused by Notch3 gain-of-function mutation involves ER and oxidative stress and blunting of NO∕sGC∕cGMP pathway. Clinical Science, 135(6), pp. 753-773. (doi: 10.1042/CS20201412) (PMID:33681964)

2020

Rossitto, G. et al. (2020) Reduced lymphatic reserve in heart failure with preserved ejection fraction. Journal of the American College of Cardiology, 76(24), pp. 2817-2829. (doi: 10.1016/j.jacc.2020.10.022) (PMID:33303070) (PMCID:PMC7724570)

Cameron, A. C. et al. (2020) Comprehensive characterisation of the vascular effects of cisplatin-based chemotherapy in patients with testicular cancer. JACC: CardioOncology, 2(3), pp. 443-455. (doi: 10.1016/j.jaccao.2020.06.004) (PMID:33043304) (PMCID:PMC7539369)

Rossitto, G. et al. (2020) Tissue sodium excess is not hypertonic and reflects extracellular volume expansion. Nature Communications, 11, 4222. (doi: 10.1038/s41467-020-17820-2) (PMID:32839436) (PMCID:PMC7445299)

Zou, Z.-G. et al. (2020) Epidermal growth factor signaling through transient receptor potential melastatin 7 cation channel regulates vascular smooth muscle cell function. Clinical Science, 134(15), pp. 2019-2035. (doi: 10.1042/CS20200827) (PMID:32706027) (PMCID:PMC8299307)

Touyz, Rhian ORCID logoORCID: https://orcid.org/0000-0003-0670-0887, Rios, Francisco ORCID logoORCID: https://orcid.org/0000-0002-8194-0787, Alves-Lopes, Rhéure, Neves, Karla B. ORCID logoORCID: https://orcid.org/0000-0001-5158-9263, De Lucca Camargo, Livia ORCID logoORCID: https://orcid.org/0000-0002-7451-7147 and Montezano, Augusto C. (2020) Oxidative stress: a unifying paradigm in hypertension. Canadian Journal of Cardiology, 36, pp. 659-670. (doi: 10.1016/j.cjca.2020.02.081) (PMID:32389339) (PMCID:PMC7225748)

Cameron, Alan C., Welsh, Paul ORCID logoORCID: https://orcid.org/0000-0002-7970-3643, Neves, Karla Bianca ORCID logoORCID: https://orcid.org/0000-0001-5158-9263, Newby, David, Touyz, Rhian M. ORCID logoORCID: https://orcid.org/0000-0003-0670-0887 and Lang, Ninian ORCID logoORCID: https://orcid.org/0000-0001-8441-6887 (2020) Acute vascular effects of vascular endothelial growth factor inhibition in the forearm arterial circulation. Journal of Hypertension, 38(2), pp. 257-265. (doi: 10.1097/HJH.0000000000002230) (PMID:31449168) (PMCID:PMC7197298)

Alves-Lopes, Rhéure, Neves, Karla B. ORCID logoORCID: https://orcid.org/0000-0001-5158-9263, Anagnostopoulou, Aikaterini, Rios, Francisco J. ORCID logoORCID: https://orcid.org/0000-0002-8194-0787, Lacchini, Silvia, Montezano, Augusto C. and Touyz, Rhian M. ORCID logoORCID: https://orcid.org/0000-0003-0670-0887 (2020) Crosstalk between vascular redox and calcium signaling in hypertension involves TRPM2 (Transient Receptor Potential Melastatin 2) cation channel. Hypertension, 75(1), pp. 139-149. (doi: 10.1161/hypertensionaha.119.13861) (PMID:31735084)

2019

Morris, Hannah, Neves, Karla B. ORCID logoORCID: https://orcid.org/0000-0001-5158-9263, Montezano, Augusto C., Maclean, Margaret R. and Touyz, Rhian ORCID logoORCID: https://orcid.org/0000-0003-0670-0887 (2019) Notch3 signaling and vascular remodeling in pulmonary arterial hypertension. Clinical Science, 133(24), pp. 2481-2498. (doi: 10.1042/CS20190835) (PMID:31868216) (PMCID:PMC6928565)

Neves, K. B. et al. (2019) ER stress and Rho kinase activation underlie the vasculopathy of CADASIL. JCI Insight, 4(23), e131344. (doi: 10.1172/jci.insight.131344) (PMID:31647781) (PMCID:PMC6962020)

Neves, Karla Bianca ORCID logoORCID: https://orcid.org/0000-0001-5158-9263 and Touyz, Rhian M. ORCID logoORCID: https://orcid.org/0000-0003-0670-0887 (2019) Extracellular vesicles as biomarkers and biovectors in primary aldosteronism. Hypertension, 74(2), pp. 250-252. (doi: 10.1161/hypertensionaha.119.13088) (PMID:31230536)

Alves-Lopes, Rhéure, Neves, Karla B. ORCID logoORCID: https://orcid.org/0000-0001-5158-9263 and Touyz, Rhian M. ORCID logoORCID: https://orcid.org/0000-0003-0670-0887 (2019) Muscarinic receptor type-3 (MR3) in hypertension and cholinergic-adrenergic crosstalk: genetic insights and potential for new antihypertensive targets. Canadian Journal of Cardiology, 35(5), pp. 555-557. (doi: 10.1016/j.cjca.2019.02.003) (PMID:30954389) (PMCID:PMC6499128)

Neves, Karla B. ORCID logoORCID: https://orcid.org/0000-0001-5158-9263, Rios, Francisco J. ORCID logoORCID: https://orcid.org/0000-0002-8194-0787, Jones, Robert ORCID logoORCID: https://orcid.org/0000-0002-2904-6980, Evans, Thomas Ronald Jeffry ORCID logoORCID: https://orcid.org/0000-0002-4175-914X, Montezano, Augusto C. and Touyz, Rhian M. ORCID logoORCID: https://orcid.org/0000-0003-0670-0887 (2019) Microparticles from vascular endothelial growth factor pathway inhibitor-treated cancer patients mediate endothelial cell injury. Cardiovascular Research, 115(5), pp. 978-988. (doi: 10.1093/cvr/cvz021) (PMID:30753341) (PMCID:PMC6452312)

Neves, Karla B. ORCID logoORCID: https://orcid.org/0000-0001-5158-9263 and Touyz, Rhian M. ORCID logoORCID: https://orcid.org/0000-0003-0670-0887 (2019) Vascular signaling. In: Touyz, Rhian M. and Delles, Christian (eds.) Textbook of Vascular Medicine. Springer: Cham, pp. 83-91. ISBN 9783030164805 (doi: 10.1007/978-3-030-16481-2_8)

2018

Neves, Karla Bianca ORCID logoORCID: https://orcid.org/0000-0001-5158-9263, Nguyen Dinh Cat, Aurelie, Alves-Lopes, Rheure ORCID logoORCID: https://orcid.org/0000-0002-4885-6647, Harvey, Katie Yates, da Costa, Rafael Menezes, Lobato, Nubia Souza, Montezano, Augusto Cesar, Oliveira, Ana Maria, Touyz, Rhian M. ORCID logoORCID: https://orcid.org/0000-0003-0670-0887 and Tostes, Rita C. (2018) Chemerin receptor blockade improves vascular function in diabetic obese mice via redox-sensitive- and Akt-dependent pathways. American Journal of Physiology: Heart and Circulatory Physiology, 315(6), H1851-H1860. (doi: 10.1152/ajpheart.00285.2018) (PMID:30216119) (PMCID:PMC6336978)

Neves, Karla Bianca ORCID logoORCID: https://orcid.org/0000-0001-5158-9263, Montezano, Augusto Cesar, Alves-Lopes, Rheure ORCID logoORCID: https://orcid.org/0000-0002-4885-6647, Bruder-Nascimento, Thiago, Costa, Rafael Menezes, Costa, Roberto S, Touyz, Rhian M. ORCID logoORCID: https://orcid.org/0000-0003-0670-0887 and Tostes, Rita C. (2018) Upregulation of Nrf2 and decreased redox signaling contribute to renoprotective effects of chemerin receptor blockade in diabetic mice. International Journal of Molecular Sciences, 19(8), 2454. (doi: 10.3390/ijms19082454) (PMID:30126255) (PMCID:PMC6121242)

Montezano, A. C. et al. (2018) NADPH oxidase 5 is a pro‐contractile Nox isoform and a point of cross‐talk for calcium and redox signaling‐implications in vascular function. Journal of the American Heart Association, 7(12), e009388. (doi: 10.1161/JAHA.118.009388) (PMID:29907654) (PMCID:PMC6220544)

Montezano, A. C. et al. (2018) NADPH Oxidase 5 is a pro‐contractile Nox isoform and a point of cross‐talk for calcium and redox signaling‐implications in vascular function. Journal of the American Heart Association, 7(12), (doi: 10.1161/JAHA.118.009388) (PMID:29907654) (PMCID:PMC6220544)

Neves, Karla B. ORCID logoORCID: https://orcid.org/0000-0001-5158-9263, Rios, Francisco J. ORCID logoORCID: https://orcid.org/0000-0002-8194-0787, Van Der Mey, Lucas, Alves-Lopes, Rheure ORCID logoORCID: https://orcid.org/0000-0002-4885-6647, Cameron, Alan C., Volpe, Massimo, Montezano, Augusto C., Savoia, Carmine and Touyz, Rhian M. ORCID logoORCID: https://orcid.org/0000-0003-0670-0887 (2018) VEGFR (vascular endothelial growth factor receptor) inhibition induces cardiovascular damage via redox-sensitive processes. Hypertension, 71(4), pp. 638-647. (doi: 10.1161/HYPERTENSIONAHA.117.10490) (PMID:29483228)

Costa, Rafael M., Neves, Karla B. ORCID logoORCID: https://orcid.org/0000-0001-5158-9263, Tostes, Rita C. and Lobato, Núbia S. (2018) Perivascular adipose tissue as a relevant fat depot for cardiovascular risk in obesity. Frontiers in Physiology, 9, 253. (doi: 10.3389/fphys.2018.00253)

Souza-Silva, Leonardo, Alves-Lopes, Rhéure ORCID logoORCID: https://orcid.org/0000-0002-4885-6647, Silva Miguez, Jéssica, Dela Justina, Vanessa, Neves, Karla Bianca ORCID logoORCID: https://orcid.org/0000-0001-5158-9263, Mestriner, Fabíola Leslie, Tostes, Rita C., Giachini, Fernanda Regina and Lima, Victor V. (2018) Glycosylation with O-linked β-N-acetylglucosamine (O-GlcNAc) induces vascular dysfunction via production of superoxide anion/reactive oxygen species. Canadian Journal of Physiology and Pharmacology, 96(3), pp. 232-240. (doi: 10.1139/cjpp-2017-0225) (PMID:28793197)

2017

Carneiro, Fernando Silva, Alves-Lopes, Rhéure ORCID logoORCID: https://orcid.org/0000-0002-4885-6647, Neves, Karla B. ORCID logoORCID: https://orcid.org/0000-0001-5158-9263, Silva, Marcondes A.B., Olivon, Vânia C., Ruginsk, Silvia G., Antunes-Rodrigues, José, Ramalho, Leandra N.Z. and Tostes, Rita C. (2017) Functional and structural changes in internal pudendal arteries underlie erectile dysfunction induced by androgen deprivation. Asian Journal of Andrology, 19(5), pp. 526-532. (doi: 10.4103/1008-682X.173935) (PMID:27391248) (PMCID:PMC5566844)

Montezano, Augusto C., Lopes, Rheure A.M. ORCID logoORCID: https://orcid.org/0000-0002-4885-6647, Neves, Karla B. ORCID logoORCID: https://orcid.org/0000-0001-5158-9263, Rios, Francisco ORCID logoORCID: https://orcid.org/0000-0002-8194-0787 and Touyz, Rhian M. ORCID logoORCID: https://orcid.org/0000-0003-0670-0887 (2017) Isolation and culture of vascular smooth muscle cells from small and large vessels. In: Touyz, Rhian M. and Schiffrin, Ernesto L. (eds.) Hypertension: Methods and Protocols. Series: Methods in molecular biology (1527). Springer: New York, pp. 349-354. ISBN 9781493966233 (doi: 10.1007/978-1-4939-6625-7_27)

Montezano, Augusto C., Neves, Karla B. ORCID logoORCID: https://orcid.org/0000-0001-5158-9263, Lopes, Rheure A.M. ORCID logoORCID: https://orcid.org/0000-0002-4885-6647 and Rios, Francisco ORCID logoORCID: https://orcid.org/0000-0002-8194-0787 (2017) Isolation and culture of endothelial cells from large vessels. In: Touyz, Rhian M. and Schiffrin, Ernesto L. (eds.) Hypertension: Methods and Protocols. Series: Methods in molecular biology (1527). Springer: New York, pp. 345-348. ISBN 9781493966233 (doi: 10.1007/978-1-4939-6625-7_26)

2016

Alves-Lopes, Rhéure ORCID logoORCID: https://orcid.org/0000-0002-4885-6647, Neves, Karla B. ORCID logoORCID: https://orcid.org/0000-0001-5158-9263, Montezano, Augusto, Harvey, Adam, Carneiro, Fernando S., Touyz, Rhian ORCID logoORCID: https://orcid.org/0000-0003-0670-0887 and Tostes, Rita C. (2016) Internal pudendal artery dysfunction in diabetes is mediated by Nox1-derived Ros, NRF2- and RHO kinase-depedent mechanisms. Hypertension, 68(4), pp. 1056-1064. (doi: 10.1161/HYPERTENSIONAHA.116.07518) (PMID:27528061)

2015

Lopes, Rhéure ORCID logoORCID: https://orcid.org/0000-0002-4885-6647, Neves, Karla ORCID logoORCID: https://orcid.org/0000-0001-5158-9263, Tostes, Rita, Montezano, Augusto and Touyz, Rhian ORCID logoORCID: https://orcid.org/0000-0003-0670-0887 (2015) Downregulation of nuclear factor erythroid 2–related factor and associated antioxidant genes contributes to redox-sensitive vascular dysfunction in hypertension. Hypertension, 2015(66), pp. 1240-1250. (doi: 10.1161/hypertensionaha.115.06163) (PMID:26503970)

Silva, M. A. B. et al. (2015) Mineralocorticoid receptor blockade prevents vascular remodelling in a rodent model of type 2 diabetes mellitus. Clinical Science, 129(7), pp. 533-545. (doi: 10.1042/cs20140758) (PMID:25967696)

2014

Lopes, Rheure Alves Moreira ORCID logoORCID: https://orcid.org/0000-0002-4885-6647, Neves, Karla Bianca ORCID logoORCID: https://orcid.org/0000-0001-5158-9263, Pestana, Cezar Rangel, Queiroz, André Lima, Zanotto, Camila Ziliotto, Chignalia, Andréia Z., Valim, Yara Maria, Silveira, Leonardo R., Curti, Carlos and Tostes, Rita C. (2014) Testosterone induces apoptosis in vascular smooth muscle cells via extrinsic apoptotic pathway with mitochondria-generated reactive oxygen species involvement. American Journal of Physiology: Heart and Circulatory Physiology, 306(11), H1485-H1494. (doi: 10.1152/ajpheart.00809.2013) (PMID:24658017)

2012

Lopes, Rhéure A.M. ORCID logoORCID: https://orcid.org/0000-0002-4885-6647, Neves, Karla B. ORCID logoORCID: https://orcid.org/0000-0001-5158-9263, Carneiro, Fernando S. and Tostes, Rita C. (2012) Testosterone and vascular function in aging. Frontiers in Physiology, 3, 89. (doi: 10.3389/fphys.2012.00089) (PMID:22514541) (PMCID:PMC3322529)

This list was generated on Sun Jun 15 04:04:27 2025 BST.
Jump to: Articles | Book Sections
Number of items: 41.

Articles

Neves, Karla B. ORCID logoORCID: https://orcid.org/0000-0001-5158-9263, Rios, Francisco J. ORCID logoORCID: https://orcid.org/0000-0002-8194-0787, Sevilla-Montero, Javier, Montezano, Augusto C. and Touyz, Rhian M. ORCID logoORCID: https://orcid.org/0000-0003-0670-0887 (2023) Exosomes and the cardiovascular system: role in cardiovascular health and disease. Journal of Physiology, 601(22), pp. 4923-4936. (doi: 10.1113/JP282054) (PMID:35306667) (PMCID:PMC10953460)

Montezano, A. C. et al. (2023) SARS-CoV-2 spike protein induces endothelial inflammation via ACE2 independently of viral replication. Scientific Reports, 13, 14086. (doi: 10.1038/s41598-023-41115-3) (PMID:37640791) (PMCID:PMC10462711)

Morris, Hannah E., Neves, Karla B. ORCID logoORCID: https://orcid.org/0000-0001-5158-9263, Nilsen, Margaret, Montezano, Augusto C., MacLean, Margaret R. and Touyz, Rhian M. ORCID logoORCID: https://orcid.org/0000-0003-0670-0887 (2023) Notch3/Hes5 induces vascular dysfunction in hypoxia-induced pulmonary hypertension through ER stress and redox-sensitive pathways. Hypertension, 80(8), pp. 1683-1696. (doi: 10.1161/hypertensionaha.122.20449) (PMID:37254738)

Sykes, R. A. et al. (2023) Vascular mechanisms of post-COVID-19 conditions: rho-kinase is a novel target for therapy. European Heart Journal: Cardiovascular Pharmacotherapy, 9(4), pp. 371-386. (doi: 10.1093/ehjcvp/pvad025) (PMID:37019821) (PMCID:PMC10236521)

Neves, Karla B. ORCID logoORCID: https://orcid.org/0000-0001-5158-9263, Alves‐Lopes, Rheure ORCID logoORCID: https://orcid.org/0000-0002-4885-6647, Montezano, Augusto C. and Touyz, Rhian M. ORCID logoORCID: https://orcid.org/0000-0003-0670-0887 (2023) Role of PARP and TRPM2 in VEGF inhibitor‐induced vascular dysfunction. Journal of the American Heart Association, 12(4), e027769. (doi: 10.1161/JAHA.122.027769) (PMID:36802924) (PMCID:PMC10111475)

Rios, F. J. et al. (2022) TRPM7 deficiency exacerbates cardiovascular and renal damage induced by aldosterone-salt. Communications Biology, 5, 746. (doi: 10.1038/s42003-022-03715-z) (PMID:35882956) (PMCID:PMC9325869)

Mirabito Colafella, K. M. et al. (2022) Differential effects of cyclo-oxygenase 1 and 2 inhibition on angiogenesis inhibitor-induced hypertension and kidney damage. Clinical Science, 136(9), pp. 675-694. (doi: 10.1042/CS20220182) (PMID:35441670) (PMCID:PMC9093150)

Camargo, L. L. et al. (2022) Central role of c-Src in NOX5- mediated redox signaling in vascular smooth muscle cells in human hypertension. Cardiovascular Research, 118(5), pp. 1359-1373. (doi: 10.1093/cvr/cvab171) (PMID:34320175) (PMCID:PMC8953456)

Alves-Lopes, R. et al. (2021) Selective inhibition of the C-domain of ACE (angiotensin-converting enzyme) combined with inhibition of NEP (neprilysin): a potential new therapy for hypertension. Hypertension, 78(3), pp. 604-616. (doi: 10.1161/HYPERTENSIONAHA.121.17041) (PMID:34304582) (PMCID:PMC8357049)

Da Silva, J. F. et al. (2021) Lysophosphatidylcholine induces oxidative stress in human endothelial cells via NOX5 activation - implications in atherosclerosis. Clinical Science, 135(15), pp. 1845-1858. (doi: 10.1042/CS20210468) (PMID:34269800)

van Dorst, Daan C.H., Dobbin, Stephen J.H. ORCID logoORCID: https://orcid.org/0000-0002-9111-0242, Neves, Karla B. ORCID logoORCID: https://orcid.org/0000-0001-5158-9263, Herrmann, Joerg, Herrmann, Sandra M., Versmissen, Jorie, Mathijssen, Ron H.J., Danser, A.H. Jan and Lang, Ninian N. ORCID logoORCID: https://orcid.org/0000-0001-8441-6887 (2021) Hypertension and prohypertensive antineoplastic therapies in cancer patients. Circulation Research, 128(7), pp. 1040-1061. (doi: 10.1161/CIRCRESAHA.121.318051) (PMID:33793337) (PMCID:PMC8011349)

Cameron, Alan C., Neves, Karla B. ORCID logoORCID: https://orcid.org/0000-0001-5158-9263, White, Jeff, Touyz, Rhian M. ORCID logoORCID: https://orcid.org/0000-0003-0670-0887 and Lang, Ninian N. ORCID logoORCID: https://orcid.org/0000-0001-8441-6887 (2021) Reply: Cisplatin-associated aortic thrombosis: a review of cases reported to the FDA adverse event reporting system. JACC: CardioOncology, 3(1), p. 166. (doi: 10.1016/j.jaccao.2021.01.005)

Neves, Karla B. ORCID logoORCID: https://orcid.org/0000-0001-5158-9263, Morris, Hannah, Alves-Lopes, Rhéure, Muir, Keith W. ORCID logoORCID: https://orcid.org/0000-0001-9535-022X, Moreton, Fiona, Delles, Christian ORCID logoORCID: https://orcid.org/0000-0003-2238-2612, Montezano, Augusto C. and Touyz, Rhian M. ORCID logoORCID: https://orcid.org/0000-0003-0670-0887 (2021) Peripheral arteriopathy caused by Notch3 gain-of-function mutation involves ER and oxidative stress and blunting of NO∕sGC∕cGMP pathway. Clinical Science, 135(6), pp. 753-773. (doi: 10.1042/CS20201412) (PMID:33681964)

Rossitto, G. et al. (2020) Reduced lymphatic reserve in heart failure with preserved ejection fraction. Journal of the American College of Cardiology, 76(24), pp. 2817-2829. (doi: 10.1016/j.jacc.2020.10.022) (PMID:33303070) (PMCID:PMC7724570)

Cameron, A. C. et al. (2020) Comprehensive characterisation of the vascular effects of cisplatin-based chemotherapy in patients with testicular cancer. JACC: CardioOncology, 2(3), pp. 443-455. (doi: 10.1016/j.jaccao.2020.06.004) (PMID:33043304) (PMCID:PMC7539369)

Rossitto, G. et al. (2020) Tissue sodium excess is not hypertonic and reflects extracellular volume expansion. Nature Communications, 11, 4222. (doi: 10.1038/s41467-020-17820-2) (PMID:32839436) (PMCID:PMC7445299)

Zou, Z.-G. et al. (2020) Epidermal growth factor signaling through transient receptor potential melastatin 7 cation channel regulates vascular smooth muscle cell function. Clinical Science, 134(15), pp. 2019-2035. (doi: 10.1042/CS20200827) (PMID:32706027) (PMCID:PMC8299307)

Touyz, Rhian ORCID logoORCID: https://orcid.org/0000-0003-0670-0887, Rios, Francisco ORCID logoORCID: https://orcid.org/0000-0002-8194-0787, Alves-Lopes, Rhéure, Neves, Karla B. ORCID logoORCID: https://orcid.org/0000-0001-5158-9263, De Lucca Camargo, Livia ORCID logoORCID: https://orcid.org/0000-0002-7451-7147 and Montezano, Augusto C. (2020) Oxidative stress: a unifying paradigm in hypertension. Canadian Journal of Cardiology, 36, pp. 659-670. (doi: 10.1016/j.cjca.2020.02.081) (PMID:32389339) (PMCID:PMC7225748)

Cameron, Alan C., Welsh, Paul ORCID logoORCID: https://orcid.org/0000-0002-7970-3643, Neves, Karla Bianca ORCID logoORCID: https://orcid.org/0000-0001-5158-9263, Newby, David, Touyz, Rhian M. ORCID logoORCID: https://orcid.org/0000-0003-0670-0887 and Lang, Ninian ORCID logoORCID: https://orcid.org/0000-0001-8441-6887 (2020) Acute vascular effects of vascular endothelial growth factor inhibition in the forearm arterial circulation. Journal of Hypertension, 38(2), pp. 257-265. (doi: 10.1097/HJH.0000000000002230) (PMID:31449168) (PMCID:PMC7197298)

Alves-Lopes, Rhéure, Neves, Karla B. ORCID logoORCID: https://orcid.org/0000-0001-5158-9263, Anagnostopoulou, Aikaterini, Rios, Francisco J. ORCID logoORCID: https://orcid.org/0000-0002-8194-0787, Lacchini, Silvia, Montezano, Augusto C. and Touyz, Rhian M. ORCID logoORCID: https://orcid.org/0000-0003-0670-0887 (2020) Crosstalk between vascular redox and calcium signaling in hypertension involves TRPM2 (Transient Receptor Potential Melastatin 2) cation channel. Hypertension, 75(1), pp. 139-149. (doi: 10.1161/hypertensionaha.119.13861) (PMID:31735084)

Morris, Hannah, Neves, Karla B. ORCID logoORCID: https://orcid.org/0000-0001-5158-9263, Montezano, Augusto C., Maclean, Margaret R. and Touyz, Rhian ORCID logoORCID: https://orcid.org/0000-0003-0670-0887 (2019) Notch3 signaling and vascular remodeling in pulmonary arterial hypertension. Clinical Science, 133(24), pp. 2481-2498. (doi: 10.1042/CS20190835) (PMID:31868216) (PMCID:PMC6928565)

Neves, K. B. et al. (2019) ER stress and Rho kinase activation underlie the vasculopathy of CADASIL. JCI Insight, 4(23), e131344. (doi: 10.1172/jci.insight.131344) (PMID:31647781) (PMCID:PMC6962020)

Neves, Karla Bianca ORCID logoORCID: https://orcid.org/0000-0001-5158-9263 and Touyz, Rhian M. ORCID logoORCID: https://orcid.org/0000-0003-0670-0887 (2019) Extracellular vesicles as biomarkers and biovectors in primary aldosteronism. Hypertension, 74(2), pp. 250-252. (doi: 10.1161/hypertensionaha.119.13088) (PMID:31230536)

Alves-Lopes, Rhéure, Neves, Karla B. ORCID logoORCID: https://orcid.org/0000-0001-5158-9263 and Touyz, Rhian M. ORCID logoORCID: https://orcid.org/0000-0003-0670-0887 (2019) Muscarinic receptor type-3 (MR3) in hypertension and cholinergic-adrenergic crosstalk: genetic insights and potential for new antihypertensive targets. Canadian Journal of Cardiology, 35(5), pp. 555-557. (doi: 10.1016/j.cjca.2019.02.003) (PMID:30954389) (PMCID:PMC6499128)

Neves, Karla B. ORCID logoORCID: https://orcid.org/0000-0001-5158-9263, Rios, Francisco J. ORCID logoORCID: https://orcid.org/0000-0002-8194-0787, Jones, Robert ORCID logoORCID: https://orcid.org/0000-0002-2904-6980, Evans, Thomas Ronald Jeffry ORCID logoORCID: https://orcid.org/0000-0002-4175-914X, Montezano, Augusto C. and Touyz, Rhian M. ORCID logoORCID: https://orcid.org/0000-0003-0670-0887 (2019) Microparticles from vascular endothelial growth factor pathway inhibitor-treated cancer patients mediate endothelial cell injury. Cardiovascular Research, 115(5), pp. 978-988. (doi: 10.1093/cvr/cvz021) (PMID:30753341) (PMCID:PMC6452312)

Neves, Karla Bianca ORCID logoORCID: https://orcid.org/0000-0001-5158-9263, Nguyen Dinh Cat, Aurelie, Alves-Lopes, Rheure ORCID logoORCID: https://orcid.org/0000-0002-4885-6647, Harvey, Katie Yates, da Costa, Rafael Menezes, Lobato, Nubia Souza, Montezano, Augusto Cesar, Oliveira, Ana Maria, Touyz, Rhian M. ORCID logoORCID: https://orcid.org/0000-0003-0670-0887 and Tostes, Rita C. (2018) Chemerin receptor blockade improves vascular function in diabetic obese mice via redox-sensitive- and Akt-dependent pathways. American Journal of Physiology: Heart and Circulatory Physiology, 315(6), H1851-H1860. (doi: 10.1152/ajpheart.00285.2018) (PMID:30216119) (PMCID:PMC6336978)

Neves, Karla Bianca ORCID logoORCID: https://orcid.org/0000-0001-5158-9263, Montezano, Augusto Cesar, Alves-Lopes, Rheure ORCID logoORCID: https://orcid.org/0000-0002-4885-6647, Bruder-Nascimento, Thiago, Costa, Rafael Menezes, Costa, Roberto S, Touyz, Rhian M. ORCID logoORCID: https://orcid.org/0000-0003-0670-0887 and Tostes, Rita C. (2018) Upregulation of Nrf2 and decreased redox signaling contribute to renoprotective effects of chemerin receptor blockade in diabetic mice. International Journal of Molecular Sciences, 19(8), 2454. (doi: 10.3390/ijms19082454) (PMID:30126255) (PMCID:PMC6121242)

Montezano, A. C. et al. (2018) NADPH oxidase 5 is a pro‐contractile Nox isoform and a point of cross‐talk for calcium and redox signaling‐implications in vascular function. Journal of the American Heart Association, 7(12), e009388. (doi: 10.1161/JAHA.118.009388) (PMID:29907654) (PMCID:PMC6220544)

Montezano, A. C. et al. (2018) NADPH Oxidase 5 is a pro‐contractile Nox isoform and a point of cross‐talk for calcium and redox signaling‐implications in vascular function. Journal of the American Heart Association, 7(12), (doi: 10.1161/JAHA.118.009388) (PMID:29907654) (PMCID:PMC6220544)

Neves, Karla B. ORCID logoORCID: https://orcid.org/0000-0001-5158-9263, Rios, Francisco J. ORCID logoORCID: https://orcid.org/0000-0002-8194-0787, Van Der Mey, Lucas, Alves-Lopes, Rheure ORCID logoORCID: https://orcid.org/0000-0002-4885-6647, Cameron, Alan C., Volpe, Massimo, Montezano, Augusto C., Savoia, Carmine and Touyz, Rhian M. ORCID logoORCID: https://orcid.org/0000-0003-0670-0887 (2018) VEGFR (vascular endothelial growth factor receptor) inhibition induces cardiovascular damage via redox-sensitive processes. Hypertension, 71(4), pp. 638-647. (doi: 10.1161/HYPERTENSIONAHA.117.10490) (PMID:29483228)

Costa, Rafael M., Neves, Karla B. ORCID logoORCID: https://orcid.org/0000-0001-5158-9263, Tostes, Rita C. and Lobato, Núbia S. (2018) Perivascular adipose tissue as a relevant fat depot for cardiovascular risk in obesity. Frontiers in Physiology, 9, 253. (doi: 10.3389/fphys.2018.00253)

Souza-Silva, Leonardo, Alves-Lopes, Rhéure ORCID logoORCID: https://orcid.org/0000-0002-4885-6647, Silva Miguez, Jéssica, Dela Justina, Vanessa, Neves, Karla Bianca ORCID logoORCID: https://orcid.org/0000-0001-5158-9263, Mestriner, Fabíola Leslie, Tostes, Rita C., Giachini, Fernanda Regina and Lima, Victor V. (2018) Glycosylation with O-linked β-N-acetylglucosamine (O-GlcNAc) induces vascular dysfunction via production of superoxide anion/reactive oxygen species. Canadian Journal of Physiology and Pharmacology, 96(3), pp. 232-240. (doi: 10.1139/cjpp-2017-0225) (PMID:28793197)

Carneiro, Fernando Silva, Alves-Lopes, Rhéure ORCID logoORCID: https://orcid.org/0000-0002-4885-6647, Neves, Karla B. ORCID logoORCID: https://orcid.org/0000-0001-5158-9263, Silva, Marcondes A.B., Olivon, Vânia C., Ruginsk, Silvia G., Antunes-Rodrigues, José, Ramalho, Leandra N.Z. and Tostes, Rita C. (2017) Functional and structural changes in internal pudendal arteries underlie erectile dysfunction induced by androgen deprivation. Asian Journal of Andrology, 19(5), pp. 526-532. (doi: 10.4103/1008-682X.173935) (PMID:27391248) (PMCID:PMC5566844)

Alves-Lopes, Rhéure ORCID logoORCID: https://orcid.org/0000-0002-4885-6647, Neves, Karla B. ORCID logoORCID: https://orcid.org/0000-0001-5158-9263, Montezano, Augusto, Harvey, Adam, Carneiro, Fernando S., Touyz, Rhian ORCID logoORCID: https://orcid.org/0000-0003-0670-0887 and Tostes, Rita C. (2016) Internal pudendal artery dysfunction in diabetes is mediated by Nox1-derived Ros, NRF2- and RHO kinase-depedent mechanisms. Hypertension, 68(4), pp. 1056-1064. (doi: 10.1161/HYPERTENSIONAHA.116.07518) (PMID:27528061)

Lopes, Rhéure ORCID logoORCID: https://orcid.org/0000-0002-4885-6647, Neves, Karla ORCID logoORCID: https://orcid.org/0000-0001-5158-9263, Tostes, Rita, Montezano, Augusto and Touyz, Rhian ORCID logoORCID: https://orcid.org/0000-0003-0670-0887 (2015) Downregulation of nuclear factor erythroid 2–related factor and associated antioxidant genes contributes to redox-sensitive vascular dysfunction in hypertension. Hypertension, 2015(66), pp. 1240-1250. (doi: 10.1161/hypertensionaha.115.06163) (PMID:26503970)

Silva, M. A. B. et al. (2015) Mineralocorticoid receptor blockade prevents vascular remodelling in a rodent model of type 2 diabetes mellitus. Clinical Science, 129(7), pp. 533-545. (doi: 10.1042/cs20140758) (PMID:25967696)

Lopes, Rheure Alves Moreira ORCID logoORCID: https://orcid.org/0000-0002-4885-6647, Neves, Karla Bianca ORCID logoORCID: https://orcid.org/0000-0001-5158-9263, Pestana, Cezar Rangel, Queiroz, André Lima, Zanotto, Camila Ziliotto, Chignalia, Andréia Z., Valim, Yara Maria, Silveira, Leonardo R., Curti, Carlos and Tostes, Rita C. (2014) Testosterone induces apoptosis in vascular smooth muscle cells via extrinsic apoptotic pathway with mitochondria-generated reactive oxygen species involvement. American Journal of Physiology: Heart and Circulatory Physiology, 306(11), H1485-H1494. (doi: 10.1152/ajpheart.00809.2013) (PMID:24658017)

Lopes, Rhéure A.M. ORCID logoORCID: https://orcid.org/0000-0002-4885-6647, Neves, Karla B. ORCID logoORCID: https://orcid.org/0000-0001-5158-9263, Carneiro, Fernando S. and Tostes, Rita C. (2012) Testosterone and vascular function in aging. Frontiers in Physiology, 3, 89. (doi: 10.3389/fphys.2012.00089) (PMID:22514541) (PMCID:PMC3322529)

Book Sections

Neves, Karla B. ORCID logoORCID: https://orcid.org/0000-0001-5158-9263 and Touyz, Rhian M. ORCID logoORCID: https://orcid.org/0000-0003-0670-0887 (2019) Vascular signaling. In: Touyz, Rhian M. and Delles, Christian (eds.) Textbook of Vascular Medicine. Springer: Cham, pp. 83-91. ISBN 9783030164805 (doi: 10.1007/978-3-030-16481-2_8)

Montezano, Augusto C., Lopes, Rheure A.M. ORCID logoORCID: https://orcid.org/0000-0002-4885-6647, Neves, Karla B. ORCID logoORCID: https://orcid.org/0000-0001-5158-9263, Rios, Francisco ORCID logoORCID: https://orcid.org/0000-0002-8194-0787 and Touyz, Rhian M. ORCID logoORCID: https://orcid.org/0000-0003-0670-0887 (2017) Isolation and culture of vascular smooth muscle cells from small and large vessels. In: Touyz, Rhian M. and Schiffrin, Ernesto L. (eds.) Hypertension: Methods and Protocols. Series: Methods in molecular biology (1527). Springer: New York, pp. 349-354. ISBN 9781493966233 (doi: 10.1007/978-1-4939-6625-7_27)

Montezano, Augusto C., Neves, Karla B. ORCID logoORCID: https://orcid.org/0000-0001-5158-9263, Lopes, Rheure A.M. ORCID logoORCID: https://orcid.org/0000-0002-4885-6647 and Rios, Francisco ORCID logoORCID: https://orcid.org/0000-0002-8194-0787 (2017) Isolation and culture of endothelial cells from large vessels. In: Touyz, Rhian M. and Schiffrin, Ernesto L. (eds.) Hypertension: Methods and Protocols. Series: Methods in molecular biology (1527). Springer: New York, pp. 345-348. ISBN 9781493966233 (doi: 10.1007/978-1-4939-6625-7_26)

This list was generated on Sun Jun 15 04:04:27 2025 BST.

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