Dr John Mercer

  • Senior Lecturer (Cardiovascular & Metabolic Health)

telephone: 01413302929
email: John.Mercer@glasgow.ac.uk

Bhf, Cardiovascular Research Centre, G12 8ta

Import to contacts

ORCID iDhttps://orcid.org/0000-0002-3204-7511

Biography

John is a Senior Lecturer at the School of Cardiovascular & Metabolic Health (SCMH) at the University of Glasgow. He has successfully developed cross-disciplinary and applied research projects with the School of Engineering, Computer Sciences, and the NHS. He has networked across national and international boundaries towards developing new types of cardiovascular implantable devices. He is an expert in leading the design concept, prototyping and biologically validating his group’s prototyping and has led preclinical testing of devices with commercial potential. His basic research projects investigated the role of nuclear DNA damage and mitochondrial dysfunction in transgenic models of atherosclerosis with the goal of developing new translational therapies.

John graduated from Oxford Brookes with a BSc (Hons) in Cell and Molecular biology in 1995 and then undertook an MPhil/PhD investigating the emerging role of p53 in radiation induced mutations in thyroid cancer at the radiobiology labs at Berkeley, graduating from the University of St Andrews in 2000. He was recruited to Glasgow in 2013.

For his postdoctoral research, John joined the University of Cambridge, Department of Medicine at Addenbrooke’s hospital. At this British Heart Foundation (BHF) Cardiovascular Research Centre of Excellence where he investigated the inducible role of p53 in vascular smooth muscle cell (vsmc) biology, with a significant emphasis of developing transgenic mouse models of disease. In 2003 John won a British Atherosclerosis Society (BAS) Young Investigator award and an International travel award in 2004. His research led to further investigations into the upstream DNA damage repair kinase, Ataxia Talengectasia (ATM) in the ApoE model of atherosclerosis. This work was supported by BHF program grants, and as well as investigating the mechanism of vsmc senescence and nuclear DNA damage, it also highlighted the emerging role mitochondrial DNA damage in vsmc bioenergetics. Collaborations with Dr Mike Murphy at the MRC Mitochondrial Biology Unit on the role of mitochondrial targeted antioxidants, such as MitoQ and the role of DNA damage in promoting metabolic syndrome with Prof.Toni-Vidal Puig led to him being awarded the European Atherosclerosis Society (EAS) Young Investigator Award in Gothenburg in 2011.

As Senior Lecturer his goal is to exploit this area of investigation and John has developed a strong multidisciplinary team in collaboration with Prof Steve Neale from the James Watt Nanofabrication Centre (JWNC), Glasgow and Prof Hadi Heidari. The group includes vascular biologists, micro and nano engineers and clinical leads from the NHS. John is based at the British Heart Foundation Glasgow Cardiovascular Research Centre (BHF GCRC). This is a BHF Translational Centre of Research Excellence with a focus on primary and secondary prevention of cardiovascular disease. To help accelerate development of transformative technologies related to cardiovascular disease John was awarded a Lord Kelvin Adam Smith PhD scholarship in 2015 and an EPSRC-DTP PhD scholarship in 2019, MRC Precision Medicine PhD 2023.

Research interests

Current Research: Active and self-reporting Vascular implants. Using advanced bioengineering techniques towards developing novel cardiovascular medical implants for arteriovenous grafts and peripheral vascular disease, cardiac, renal and paediatric applications. Leads on Vascugraft, VascuStent and VascuValve projects with advanced wireless data and powering of diagnostic and therapeutic features.

Previous Research: Role of mitochondrial dysfunction in Atherosclerosis, transgenic models of disease. DNA damage and repair, role of p53 / ATM axis in vascular smooth muscle damage response pathways, including Lin28 and anti-aging Klotho on metabolic switching between oxidative and glycolytic metabolism.

Research Expertise: Transgenic models of disease, bioengineering, design and fabrication, Electrical impedance spectroscopy (EIS), biosensor microfabrication, vessel phantoms, biocompatible 2D and 3D printing and secondary processes. Timelapse and fluorescent microscopy for cell and blood products.

Reviewer:

British Heart foundation, Medical Research Council, European Council, Biochemistry Society, Hypertension Journal, Clinical Sciences, British Journal of Pharmacology, FEBS Journal, Biosciences Reports, Oncotaget, IEEE Sensors, BMC Series and others.

Funding:

Project title: Development of therapeutic telemetry system for a self-reporting covered stent: Phase 2
Timescale: 2023-26 (Pending contract
Funding body Philips Healthcare Global
Total Award: £517,872
Applications Lead PI John Mercer
Co-Applicants Steve Neale – School of Engineering

Project title: VascuSens – Auto calibrating implants
Timescale: 2023
Funding body Welcome IAA
Total Award: £43,765
Applications Lead PI John Mercer
Co-Applicants Steve Neale – Hadi Heidari – School of Engineering

Project title: VascuSenS – A therapeutic vascular biosensor for a self-reporting stent graft
Timescale: 2022-23
Funding body British Heart Foundation
Total Award: £50,000
Applications Lead PI John Mercer Steve Neale & Hadi Heidari – School of Engineering

Project title: VascuSenS – A therapeutic vascular biosensor for a self-reporting stent graft
Timescale: 2022-23
Funding body Reinvigorating Research, UofG
Total Award: £40,000
Applications Lead PI John Mercer

Project title: Development of therapeutic telemetry system for a self-reporting covered stent: Phase 1&2
Timescale: 2022-23
Funding body Philips Healthcare BRIDGE program
Total Award: £80,400
Applications Lead PI John Mercer

Project title: Economic Case for self-reporting vascular grafts
Timescale: 2022-23
Funding body Glasgow Knowledge Exchange Fund
Total Award: £38,163
Applications Lead PI John Mercer, Olivia Wu, Neil Hawkins

Project title: VascuSens – An advanced A Self Reporting Vascular Graft Development Part 2
Timescale: 2022-2023
Funding body Glasgow Knowledge Exchange Fund
Total Award: £38,967 (£24,193 plus £14,774)
Applications Lead PI John Mercer

Project title: VascuSens – An Advanced Self Reporting Vascular Graft Development Part 1
Timescale: 2021-2022
Funding body Glasgow Knowledge Exchange Fund
Total Award: £10,000
Applications Lead PI John Mercer,

Project title: Advanced Wireless Power transfer to a SMART Cardiovascular implantable medical device
Timescale: 2021-2022
Funding body Flexible Glasgow Knowledge Exchange Fund
Total Award: £2000
Applications Lead PI John Mercer, Hadi Heidari

Project title: Development of SMART intravascular biosensor for Cardiovascular disease II
Timescale: 2021-2022
Funding body MRC Confidence in Concept – University of Edinburgh
Total Award: £80,000
Applications Srinjoy Mitra, John Mercer Co-I, Steve Neale

Project title: Development of a SMART intravascular biosensor for Cardiovascular disease I
Timescale: 2020-2021
Funding body MRC-Confidence in Concept – University of Glasgow
Total Award: £38,000
Applications Lead PI John Mercer, Steve Neale

Project title: Integration of a miniaturised impedance biosensor for detecting vascular cells using interdigitated gold biosensors
Timescale: 2019-2020
Funding body University of Glasgow – Pump prime 2
Total Award: £10,000
Applications Lead PI John Mercer, Steve Neale

Project title: A miniaturised impedance biosensor for detecting vascular cells
Timescale: 2019-2020
Funding body University of Glasgow – Pump prime 1
Total Award: £8000
Applications Lead PI John Mercer, Steve Neale
Ownership: 50% Project title:

Project title: Fabrication and validation of a remote-controlled cardiovascular biosensor
Timescale: 2017-2018
Funding body CSO Chief Scientific Office
Total Award: £20,000
Applications Lead PI John Mercer, Steve Neale
Ownership: 50% Project title:

Project title: Development of a SMART stent for cardiovascular disease
Timescale: 2016-2017
Funding body British Heart Foundation
Total Award: £20,000
Applications Lead PI John Mercer, Steve Neale

Publications

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Jump to: 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2016 | 2015 | 2014 | 2013 | 2012 | 2010 | 2008 | 2007 | 2006 | 2005 | 2001
Number of items: 42.

2024

Kirimi, M.T., Hoare, D., Holsgrove, M., Czyzewski, J., Mirzai, N., Mercer, J.R. and Neale, S. (2024) Detection of blood clots using a whole stent as an active implantable biosensor. Advanced Science, (doi: 10.1002/advs.202304748) (PMID:38342628) (Early Online Publication)

Hoare, D., Kingsmore, D., Holsgrove, M., Russell, E., Kirimi, M. T., Czyzewski, J., Mirzai, N., Kennedy, S. , Neale, S. L. and Mercer, J. R. (2024) Realtime monitoring of thrombus formation in vivo using a self-reporting vascular access graft. Communications Medicine, 4, 15. (doi: 10.1038/s43856-024-00436-8) (PMID:38316912) (PMCID:PMC10844314)

2023

Zhang, J., Wagih, M. , Hoare, D., Mirzai, N., Mercer, J. , Das, R. and Heidari, H. (2023) Highly Integrated and Ultra-Compact Rectenna with Wireless Powering for Implantable Vascular Devices. In: 21st IEEE Interregional NEWCAS Conference (IEEE NEWCAS 2023), Edinburgh, UK, 26-28 June 2023, ISBN 9798350300246 (doi: 10.1109/NEWCAS57931.2023.10198083)

Zhang, J., Das, R. , Hoare, D., Wang, H., Ofiare, A., Mirzai, N., Mercer, J. and Heidari, H. (2023) A compact dual-band implantable antenna for wireless biotelemetry in arteriovenous grafts. IEEE Transactions on Antennas and Propagation, 71(6), pp. 4759-4771. (doi: 10.1109/TAP.2023.3266786)

Marland, J. R.K., Tsiamis, A., Hoare, D., Ledesma Lopez, P. G., Neale, S. L. , Mercer, J. R. and Mitra, S. (2023) Towards synthetic vascular graft monitoring using a flip-chip-on-flex impedance spectroscopy sensor. IEEE Sensors Journal, 23(1), pp. 88-96. (doi: 10.1109/JSEN.2022.3220022)

2022

Zhang, J., Hoare, D., Das, R. , Holsgrove, M., Czyzewski, J., Mirzai, N., Mercer, J. and Heidari, H. (2022) Wireless Impedance Platform for Autonomous Vascular Implantable Devices. In: 29th IEEE International Conference on Electronics, Circuits and Systems (ICECS 2022), Glasgow, UK, 24-26 October 2022, ISBN 9781665488235 (doi: 10.1109/ICECS202256217.2022.9970833)

Hoare, D., Fisher, S., Nelson, F., Tsiamis, A., Marland, J. R. K., Mitra, S., Neale, S. L. and Mercer, J. (2022) An Impedance Sensor for Pathologically Relevant Detection of In-Stent Restenosis in Vitro. In: 44th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Glasgow, 11-15 July 2022, pp. 2298-2301. ISBN 9781728127828 (doi: 10.1109/EMBC48229.2022.9871936)

Liang, X., Li, H., Vuckovic, A., Mercer, J. and Heidari, H. (2022) A neuromorphic model with delay-based reservoir for continuous ventricular heartbeat detection. IEEE Transactions on Biomedical Engineering, 69(6), pp. 1837-1849. (doi: 10.1109/TBME.2021.3129306)

Zhang, J., Das, R. , Zhao, J., Mirzai, N., Mercer, J. and Heidari, H. (2022) Battery-free and wireless technologies for cardiovascular implantable medical devices. Advanced Materials Technologies, 7(6), 2101086. (doi: 10.1002/admt.202101086)

Hoare, D. et al. (2022) Predicting cardiovascular stent complications using self-reporting biosensors for noninvasive detection of disease. Advanced Science, 9(15), 2105285. (doi: 10.1002/advs.202105285) (PMID:35322587) (PMCID:PMC9130883)

Docherty, C. K., Strembitska, A., Baker, C. P., Schmidt, F. F., Reay, K. and Mercer, J. R. (2022) Inducing energetic switching using Klotho improves vascular smooth muscle cell phenotype. International Journal of Molecular Sciences, 23(1), 217. (doi: 10.3390/ijms23010217) (PMID:35008643) (PMCID:PMC8745077)

Molloy, A., Beaumont, K., Alyami, A., Kirimi, M., Hoare, D., Mirzai, N., Heidari, H. , Mitra, S., Neale, S. L. and Mercer, J. R. (2022) Challenges to the development of the next generation of self-reporting cardiovascular implantable medical devices. IEEE Reviews in Biomedical Engineering, 15, pp. 260-272. (doi: 10.1109/RBME.2021.3110084) (PMID:34520361)

2021

Zhang, J., Das, R. , Abbasi, Q. H. , Mirzai, N., Mercer, J. and Heidari, H. (2021) Dual-band Microstrip Patch Antenna for Fully-Wireless Smart Stent. In: 2021 IEEE International Symposium on Antennas and Propagation and USNC-URSI Radio Science Meeting, Singapore, 04-10 Dec 2021, pp. 1035-1036. ISBN 9781728146706 (doi: 10.1109/APS/URSI47566.2021.9703759)

Docherty, C., Bresciani, J., Carswell, A., Chanderseka, A., Friel, E., Stasi, M. and Mercer, J. (2021) An inducible and vascular smooth muscle cell specific Pink-1 knockout induces mitochondrial dysfunction during atherogenesis. International Journal of Molecular Sciences, 22(18), 9993. (doi: 10.3390/ijms22189993) (PMID:34576157) (PMCID:PMC8467198)

Flouda, K., Mercer, J. , Davies, M. J. and Hawkins, C. L. (2021) Role of myeloperoxidase-derived oxidants in the induction of vascular smooth muscle cell damage. Free Radical Biology and Medicine, 166, pp. 165-177. (doi: 10.1016/j.freeradbiomed.2021.02.021) (PMID:33631301)

2020

Charla, E., Mercer, J. , Maffia, P. and Nicklin, S. (2020) Extracellular vesicle signalling in atherosclerosis. Cellular Signalling, 75, 109751. (doi: 10.1016/j.cellsig.2020.109751) (PMID:32860954) (PMCID:PMC7534042)

Liang, X., Fan, H., Mercer, J. and Heidari, H. (2020) A Delay-Based Neuromorphic Processor for Arrhythmias Detection. In: 2020 IEEE International Symposium on Circuits and Systems, Seville, Spain, 17-20 May 2020, ISBN 9781728133201 (doi: 10.1109/ISCAS45731.2020.9181032)

Bussooa, A., Hoare, D., Kirimi, M. T., Mitra, S., Mirzai, N., Neale, S. L. and Mercer, J. (2020) Impedimetric detection and electromediated apoptosis of vascular smooth muscle using microfabricated biosensors for diagnosis and therapeutic treatment in cardiovascular diseases. Advanced Science, 7(18), 1902999. (doi: 10.1002/advs.201902999) (PMID:32999823) (PMCID:PMC7509665)

Gnaiger, E. et al. (2020) Mitochondrial physiology. Bioenergetic Communications, 2020(1), (doi: 10.26124/bec:2020-0001.v1)

2019

Hoare, D., Bussooa, A., Neale, S. , Mirzai, N. and Mercer, J. (2019) The future of cardiovascular stents: bioresorbable and integrated biosensor technology. Advanced Science, 6(20), 1900856. (doi: 10.1002/advs.201900856) (PMID:31637160) (PMCID:PMC6794628)

Mercer, J. and Guzik, T. J. (2019) Atherosclerosis. In: Touyz, R. M. and Delles, C. (eds.) Textbook of Vascular Medicine. Springer: Cham, pp. 215-228. ISBN 9783030164805 (doi: 10.1007/978-3-030-16481-2_20)

2018

Bussooa, A., Neale, S. and Mercer, J. R. (2018) Future of smart cardiovascular implants. Sensors, 18(7), 2008. (doi: 10.3390/s18072008) (PMID:29932154) (PMCID:PMC6068883)

Docherty, C. K., Carswell, A., Friel, E. and Mercer, J. R. (2018) Impaired mitochondrial respiration in human carotid plaque atherosclerosis: a potential role for Pink1 in vascular smooth muscle cell energetics. Atherosclerosis, 268, pp. 1-11. (doi: 10.1016/j.atherosclerosis.2017.11.009) (PMID:29156421) (PMCID:PMC6565844)

2016

Docherty, C. K., Salt, I. P. and Mercer, J. R. (2016) Lin28A induces energetic switching to glycolytic metabolism in human embryonic kidney cells. Stem Cell Research and Therapy, 7(1), 78. (doi: 10.1186/s13287-016-0323-2)

2015

Gray, K. L., Kumar, S. V., Figg, N., Harrison, J., Baker, L., Mercer, J. R. , Littlewood, T. D. and Bennett, M. R. (2015) Effects of DNA damage in smooth muscle cells in atherosclerosis. Circulation Research, 116, pp. 816-826. (doi: 10.1161/CIRCRESAHA.116.304921) (PMID:25524056)

2014

Mercer, J. R. (2014) Mitochondrial bioenergetics and therapeutic intervention in cardiovascular disease. Pharmacology and Therapeutics, 141(1), pp. 13-20. (doi: 10.1016/j.pharmthera.2013.07.011) (PMID:23911986)

Zhongzhao, T., He, J., Sadat, U., Mercer, J.R. , Xiaoyan, W., Bahaei, N.S., Thomas, O.M. and Gillard, J.H. (2014) How does juxtaluminal calcium affect critical mechanical conditions in carotid atherosclerotic plaque? An exploratory study. IEEE Transactions on Biomedical Engineering, 61(1), pp. 35-40. (doi: 10.1109/TBME.2013.2275078) (PMID:23912462)

2013

Yu, E. et al. (2013) Mitochondrial DNA damage can promote atherosclerosis independently of reactive oxygen species through effects on smooth muscle cells and monocytes, and correlates with higher risk plaques in humans. Circulation, 128, pp. 702-712. (doi: 10.1161/CIRCULATIONAHA.113.002271)

Gorenne, I., Kumar, S., Gray, K., Figg, N., Yu, H., Mercer, J.R. and Bennett, M. (2013) Vascular smooth muscle cell sirtuin 1 protects against DNA damage and inhibits atherosclerosis. Circulation, 127(3), pp. 386-396. (doi: 10.1161/CIRCULATIONAHA.112.124404)

2012

Mercer, J.R. , Gray, K., Figg, N., Kumar, S. and Bennett, M.R. (2012) The methyl xanthine caffeine inhibits DNA damage signaling and reactive species and reduces atherosclerosis in ApoE-/- mice. Arteriosclerosis, Thrombosis, and Vascular Biology, 32(10), pp. 2461-2467. (doi: 10.1161/ATVBAHA.112.251322)

Blackmore, H.L., Piekarz, A.V., Fernandez‑Twinn, D.S., Mercer, J.R. , Figg, N., Bennett, M. and Ozanne, S.E. (2012) Poor maternal nutrition programmes a pro-atherosclerotic phenotype in ApoE−/−mice. Clinical Science, 123(4), pp. 251-257. (doi: 10.1042/CS20110487)

Yu, E., Mercer, J.R. and Bennett, M. (2012) Mitochondria in vascular disease. Cardiovascular Research, 95(2), pp. 173-182. (doi: 10.1093/cvr/cvs111) (PMID:22392270)

Mercer, J.R. , Yu, E., Figg, N., Cheng, K., Prime, T.A., Griffin, J.L., Masoodi, M., Vidal-Puig, A., Murphy, M.P. and Bennett, M.R. (2012) The mitochondria-targeted antioxidant MitoQ decreases features of the metabolic syndrome in ATM+/–/ApoE–/– mice. Free Radical Biology and Medicine, 52(5), pp. 841-849. (doi: 10.1016/j.freeradbiomed.2011.11.026)

2010

Mercer, J.R. , Cheng, K.-K., Figg, N., Gorenne, I., Mahmoudi, M., Griffin, J., Vidal-Puig, A., Logan, A., Murphy, M.P. and Bennett, M. (2010) DNA damage links mitochondrial dysfunction to atherosclerosis and the metabolic syndrome. Circulation Research, 107(8), pp. 1021-1031. (doi: 10.1161/CIRCRESAHA.110.218966)

2008

Mahmoudi, M., Gorenne, I., Mercer, J.R. , Figg, N., Littlewood, T. and Bennett, M. (2008) Statins use a novel nijmegen breakage syndrome-1-dependent pathway to accelerate DNA repair in vascular smooth muscle cells. Circulation Research, 103(7), pp. 717-725. (doi: 10.1161/CIRCRESAHA.108.182899)

2007

Kavurma, M.M., Figg, N., Bennett, M.R., Mercer, J.R. , Khachigian, L.M. and Littlewood, T.D. (2007) Oxidative stress regulates IGF1R expression in vascular smooth-muscle cells via p53 and HDAC recruitment. Biochemical Journal, 407(1), p. 79. (doi: 10.1042/BJ20070380)

Mercer, J.R. , Mahmoudi, M. and Bennett, M. (2007) DNA damage, p53, apoptosis and vascular disease. Mutation Research: Fundamental and Molecular Mechanisms of Mutagenesis, 621(1-2), pp. 75-86. (doi: 10.1016/j.mrfmmm.2007.02.011)

Stoneman, V., Braganza, D., Figg, N., Mercer, J.R. , Lang, R., Goddard, M. and Bennett, M. (2007) Monocyte/macrophage suppression in CD11b diphtheria toxin receptor transgenic mice differentially affects atherogenesis and established plaques. Circulation Research, 100(6), pp. 884-893. (doi: 10.1161/01.RES.0000260802.75766.00)

2006

Mercer, J.R. and Bennett, M. (2006) The role of p53 in atherosclerosis. Cell Cycle, 5(17), pp. 1907-1909. (doi: 10.4161/cc.5.17.3166)

Mahmoudi, M., Mercer, J.R. and Bennett, M. (2006) DNA damage and repair in atherosclerosis. Cardiovascular Research, 71(2), pp. 259-268. (doi: 10.1016/j.cardiores.2006.03.002)

2005

Mercer, J.R. , Figg, N., Stoneman, V., Braganza, D. and Bennett, M.R. (2005) Endogenous p53 protects vascular smooth muscle cells from apoptosis and reduces atherosclerosis in ApoE knockout mice. Circulation Research, 96(6), pp. 667-674. (doi: 10.1161/01.RES.0000161069.15577.ca)

2001

McCarthy, N., Mercer, J.R. and Bennett, M. (2001) Apoptotic proteins: p53 and c-myc related pathways. Cardiology Clinics, 19(1), pp. 75-89. (doi: 10.1016/S0733-8651(05)70196-X)

This list was generated on Sat Feb 24 10:47:52 2024 GMT.
Number of items: 42.

Articles

Kirimi, M.T., Hoare, D., Holsgrove, M., Czyzewski, J., Mirzai, N., Mercer, J.R. and Neale, S. (2024) Detection of blood clots using a whole stent as an active implantable biosensor. Advanced Science, (doi: 10.1002/advs.202304748) (PMID:38342628) (Early Online Publication)

Hoare, D., Kingsmore, D., Holsgrove, M., Russell, E., Kirimi, M. T., Czyzewski, J., Mirzai, N., Kennedy, S. , Neale, S. L. and Mercer, J. R. (2024) Realtime monitoring of thrombus formation in vivo using a self-reporting vascular access graft. Communications Medicine, 4, 15. (doi: 10.1038/s43856-024-00436-8) (PMID:38316912) (PMCID:PMC10844314)

Zhang, J., Das, R. , Hoare, D., Wang, H., Ofiare, A., Mirzai, N., Mercer, J. and Heidari, H. (2023) A compact dual-band implantable antenna for wireless biotelemetry in arteriovenous grafts. IEEE Transactions on Antennas and Propagation, 71(6), pp. 4759-4771. (doi: 10.1109/TAP.2023.3266786)

Marland, J. R.K., Tsiamis, A., Hoare, D., Ledesma Lopez, P. G., Neale, S. L. , Mercer, J. R. and Mitra, S. (2023) Towards synthetic vascular graft monitoring using a flip-chip-on-flex impedance spectroscopy sensor. IEEE Sensors Journal, 23(1), pp. 88-96. (doi: 10.1109/JSEN.2022.3220022)

Liang, X., Li, H., Vuckovic, A., Mercer, J. and Heidari, H. (2022) A neuromorphic model with delay-based reservoir for continuous ventricular heartbeat detection. IEEE Transactions on Biomedical Engineering, 69(6), pp. 1837-1849. (doi: 10.1109/TBME.2021.3129306)

Zhang, J., Das, R. , Zhao, J., Mirzai, N., Mercer, J. and Heidari, H. (2022) Battery-free and wireless technologies for cardiovascular implantable medical devices. Advanced Materials Technologies, 7(6), 2101086. (doi: 10.1002/admt.202101086)

Hoare, D. et al. (2022) Predicting cardiovascular stent complications using self-reporting biosensors for noninvasive detection of disease. Advanced Science, 9(15), 2105285. (doi: 10.1002/advs.202105285) (PMID:35322587) (PMCID:PMC9130883)

Docherty, C. K., Strembitska, A., Baker, C. P., Schmidt, F. F., Reay, K. and Mercer, J. R. (2022) Inducing energetic switching using Klotho improves vascular smooth muscle cell phenotype. International Journal of Molecular Sciences, 23(1), 217. (doi: 10.3390/ijms23010217) (PMID:35008643) (PMCID:PMC8745077)

Molloy, A., Beaumont, K., Alyami, A., Kirimi, M., Hoare, D., Mirzai, N., Heidari, H. , Mitra, S., Neale, S. L. and Mercer, J. R. (2022) Challenges to the development of the next generation of self-reporting cardiovascular implantable medical devices. IEEE Reviews in Biomedical Engineering, 15, pp. 260-272. (doi: 10.1109/RBME.2021.3110084) (PMID:34520361)

Docherty, C., Bresciani, J., Carswell, A., Chanderseka, A., Friel, E., Stasi, M. and Mercer, J. (2021) An inducible and vascular smooth muscle cell specific Pink-1 knockout induces mitochondrial dysfunction during atherogenesis. International Journal of Molecular Sciences, 22(18), 9993. (doi: 10.3390/ijms22189993) (PMID:34576157) (PMCID:PMC8467198)

Flouda, K., Mercer, J. , Davies, M. J. and Hawkins, C. L. (2021) Role of myeloperoxidase-derived oxidants in the induction of vascular smooth muscle cell damage. Free Radical Biology and Medicine, 166, pp. 165-177. (doi: 10.1016/j.freeradbiomed.2021.02.021) (PMID:33631301)

Charla, E., Mercer, J. , Maffia, P. and Nicklin, S. (2020) Extracellular vesicle signalling in atherosclerosis. Cellular Signalling, 75, 109751. (doi: 10.1016/j.cellsig.2020.109751) (PMID:32860954) (PMCID:PMC7534042)

Bussooa, A., Hoare, D., Kirimi, M. T., Mitra, S., Mirzai, N., Neale, S. L. and Mercer, J. (2020) Impedimetric detection and electromediated apoptosis of vascular smooth muscle using microfabricated biosensors for diagnosis and therapeutic treatment in cardiovascular diseases. Advanced Science, 7(18), 1902999. (doi: 10.1002/advs.201902999) (PMID:32999823) (PMCID:PMC7509665)

Gnaiger, E. et al. (2020) Mitochondrial physiology. Bioenergetic Communications, 2020(1), (doi: 10.26124/bec:2020-0001.v1)

Hoare, D., Bussooa, A., Neale, S. , Mirzai, N. and Mercer, J. (2019) The future of cardiovascular stents: bioresorbable and integrated biosensor technology. Advanced Science, 6(20), 1900856. (doi: 10.1002/advs.201900856) (PMID:31637160) (PMCID:PMC6794628)

Bussooa, A., Neale, S. and Mercer, J. R. (2018) Future of smart cardiovascular implants. Sensors, 18(7), 2008. (doi: 10.3390/s18072008) (PMID:29932154) (PMCID:PMC6068883)

Docherty, C. K., Carswell, A., Friel, E. and Mercer, J. R. (2018) Impaired mitochondrial respiration in human carotid plaque atherosclerosis: a potential role for Pink1 in vascular smooth muscle cell energetics. Atherosclerosis, 268, pp. 1-11. (doi: 10.1016/j.atherosclerosis.2017.11.009) (PMID:29156421) (PMCID:PMC6565844)

Docherty, C. K., Salt, I. P. and Mercer, J. R. (2016) Lin28A induces energetic switching to glycolytic metabolism in human embryonic kidney cells. Stem Cell Research and Therapy, 7(1), 78. (doi: 10.1186/s13287-016-0323-2)

Gray, K. L., Kumar, S. V., Figg, N., Harrison, J., Baker, L., Mercer, J. R. , Littlewood, T. D. and Bennett, M. R. (2015) Effects of DNA damage in smooth muscle cells in atherosclerosis. Circulation Research, 116, pp. 816-826. (doi: 10.1161/CIRCRESAHA.116.304921) (PMID:25524056)

Mercer, J. R. (2014) Mitochondrial bioenergetics and therapeutic intervention in cardiovascular disease. Pharmacology and Therapeutics, 141(1), pp. 13-20. (doi: 10.1016/j.pharmthera.2013.07.011) (PMID:23911986)

Zhongzhao, T., He, J., Sadat, U., Mercer, J.R. , Xiaoyan, W., Bahaei, N.S., Thomas, O.M. and Gillard, J.H. (2014) How does juxtaluminal calcium affect critical mechanical conditions in carotid atherosclerotic plaque? An exploratory study. IEEE Transactions on Biomedical Engineering, 61(1), pp. 35-40. (doi: 10.1109/TBME.2013.2275078) (PMID:23912462)

Yu, E. et al. (2013) Mitochondrial DNA damage can promote atherosclerosis independently of reactive oxygen species through effects on smooth muscle cells and monocytes, and correlates with higher risk plaques in humans. Circulation, 128, pp. 702-712. (doi: 10.1161/CIRCULATIONAHA.113.002271)

Gorenne, I., Kumar, S., Gray, K., Figg, N., Yu, H., Mercer, J.R. and Bennett, M. (2013) Vascular smooth muscle cell sirtuin 1 protects against DNA damage and inhibits atherosclerosis. Circulation, 127(3), pp. 386-396. (doi: 10.1161/CIRCULATIONAHA.112.124404)

Mercer, J.R. , Gray, K., Figg, N., Kumar, S. and Bennett, M.R. (2012) The methyl xanthine caffeine inhibits DNA damage signaling and reactive species and reduces atherosclerosis in ApoE-/- mice. Arteriosclerosis, Thrombosis, and Vascular Biology, 32(10), pp. 2461-2467. (doi: 10.1161/ATVBAHA.112.251322)

Blackmore, H.L., Piekarz, A.V., Fernandez‑Twinn, D.S., Mercer, J.R. , Figg, N., Bennett, M. and Ozanne, S.E. (2012) Poor maternal nutrition programmes a pro-atherosclerotic phenotype in ApoE−/−mice. Clinical Science, 123(4), pp. 251-257. (doi: 10.1042/CS20110487)

Yu, E., Mercer, J.R. and Bennett, M. (2012) Mitochondria in vascular disease. Cardiovascular Research, 95(2), pp. 173-182. (doi: 10.1093/cvr/cvs111) (PMID:22392270)

Mercer, J.R. , Yu, E., Figg, N., Cheng, K., Prime, T.A., Griffin, J.L., Masoodi, M., Vidal-Puig, A., Murphy, M.P. and Bennett, M.R. (2012) The mitochondria-targeted antioxidant MitoQ decreases features of the metabolic syndrome in ATM+/–/ApoE–/– mice. Free Radical Biology and Medicine, 52(5), pp. 841-849. (doi: 10.1016/j.freeradbiomed.2011.11.026)

Mercer, J.R. , Cheng, K.-K., Figg, N., Gorenne, I., Mahmoudi, M., Griffin, J., Vidal-Puig, A., Logan, A., Murphy, M.P. and Bennett, M. (2010) DNA damage links mitochondrial dysfunction to atherosclerosis and the metabolic syndrome. Circulation Research, 107(8), pp. 1021-1031. (doi: 10.1161/CIRCRESAHA.110.218966)

Mahmoudi, M., Gorenne, I., Mercer, J.R. , Figg, N., Littlewood, T. and Bennett, M. (2008) Statins use a novel nijmegen breakage syndrome-1-dependent pathway to accelerate DNA repair in vascular smooth muscle cells. Circulation Research, 103(7), pp. 717-725. (doi: 10.1161/CIRCRESAHA.108.182899)

Kavurma, M.M., Figg, N., Bennett, M.R., Mercer, J.R. , Khachigian, L.M. and Littlewood, T.D. (2007) Oxidative stress regulates IGF1R expression in vascular smooth-muscle cells via p53 and HDAC recruitment. Biochemical Journal, 407(1), p. 79. (doi: 10.1042/BJ20070380)

Mercer, J.R. , Mahmoudi, M. and Bennett, M. (2007) DNA damage, p53, apoptosis and vascular disease. Mutation Research: Fundamental and Molecular Mechanisms of Mutagenesis, 621(1-2), pp. 75-86. (doi: 10.1016/j.mrfmmm.2007.02.011)

Stoneman, V., Braganza, D., Figg, N., Mercer, J.R. , Lang, R., Goddard, M. and Bennett, M. (2007) Monocyte/macrophage suppression in CD11b diphtheria toxin receptor transgenic mice differentially affects atherogenesis and established plaques. Circulation Research, 100(6), pp. 884-893. (doi: 10.1161/01.RES.0000260802.75766.00)

Mercer, J.R. and Bennett, M. (2006) The role of p53 in atherosclerosis. Cell Cycle, 5(17), pp. 1907-1909. (doi: 10.4161/cc.5.17.3166)

Mahmoudi, M., Mercer, J.R. and Bennett, M. (2006) DNA damage and repair in atherosclerosis. Cardiovascular Research, 71(2), pp. 259-268. (doi: 10.1016/j.cardiores.2006.03.002)

Mercer, J.R. , Figg, N., Stoneman, V., Braganza, D. and Bennett, M.R. (2005) Endogenous p53 protects vascular smooth muscle cells from apoptosis and reduces atherosclerosis in ApoE knockout mice. Circulation Research, 96(6), pp. 667-674. (doi: 10.1161/01.RES.0000161069.15577.ca)

McCarthy, N., Mercer, J.R. and Bennett, M. (2001) Apoptotic proteins: p53 and c-myc related pathways. Cardiology Clinics, 19(1), pp. 75-89. (doi: 10.1016/S0733-8651(05)70196-X)

Book Sections

Mercer, J. and Guzik, T. J. (2019) Atherosclerosis. In: Touyz, R. M. and Delles, C. (eds.) Textbook of Vascular Medicine. Springer: Cham, pp. 215-228. ISBN 9783030164805 (doi: 10.1007/978-3-030-16481-2_20)

Conference Proceedings

Zhang, J., Wagih, M. , Hoare, D., Mirzai, N., Mercer, J. , Das, R. and Heidari, H. (2023) Highly Integrated and Ultra-Compact Rectenna with Wireless Powering for Implantable Vascular Devices. In: 21st IEEE Interregional NEWCAS Conference (IEEE NEWCAS 2023), Edinburgh, UK, 26-28 June 2023, ISBN 9798350300246 (doi: 10.1109/NEWCAS57931.2023.10198083)

Zhang, J., Hoare, D., Das, R. , Holsgrove, M., Czyzewski, J., Mirzai, N., Mercer, J. and Heidari, H. (2022) Wireless Impedance Platform for Autonomous Vascular Implantable Devices. In: 29th IEEE International Conference on Electronics, Circuits and Systems (ICECS 2022), Glasgow, UK, 24-26 October 2022, ISBN 9781665488235 (doi: 10.1109/ICECS202256217.2022.9970833)

Hoare, D., Fisher, S., Nelson, F., Tsiamis, A., Marland, J. R. K., Mitra, S., Neale, S. L. and Mercer, J. (2022) An Impedance Sensor for Pathologically Relevant Detection of In-Stent Restenosis in Vitro. In: 44th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Glasgow, 11-15 July 2022, pp. 2298-2301. ISBN 9781728127828 (doi: 10.1109/EMBC48229.2022.9871936)

Zhang, J., Das, R. , Abbasi, Q. H. , Mirzai, N., Mercer, J. and Heidari, H. (2021) Dual-band Microstrip Patch Antenna for Fully-Wireless Smart Stent. In: 2021 IEEE International Symposium on Antennas and Propagation and USNC-URSI Radio Science Meeting, Singapore, 04-10 Dec 2021, pp. 1035-1036. ISBN 9781728146706 (doi: 10.1109/APS/URSI47566.2021.9703759)

Liang, X., Fan, H., Mercer, J. and Heidari, H. (2020) A Delay-Based Neuromorphic Processor for Arrhythmias Detection. In: 2020 IEEE International Symposium on Circuits and Systems, Seville, Spain, 17-20 May 2020, ISBN 9781728133201 (doi: 10.1109/ISCAS45731.2020.9181032)

This list was generated on Sat Feb 24 10:47:52 2024 GMT.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Automated Nano AnaLysing, characterisatiOn and additive packaGing sUitE (ANALOGUE)
    Engineering and Physical Sciences Research Council
    2024 - 2027
     
  • Sercader VascuSenS Commercial Assessment
    Wellcome Trust
    2023 - 2023
     
  • VascuSens Follow On - Laris and Autocalibrating implants
    Medical Research Council
    2023 - 2023
     
  • VascuSens Follow On
    Medical Research Council
    2022 - 2022
     
  • Design and fabrication of a remote controlled wireless impedance sensing unit for a new cardiovascular medical device.
    Chief Scientist Office
    2017 - 2018
     

Supervision

  • Alshuwayer, Noha
    Elucidation of the role of methylarginine metabolism in regulation of nitric oxide production and inflammation in experimental atherosclerosis.
  • Kirimi, Mahmut Talha
    Smart Stent Devices

Teaching

I am coordinator of the basic science component of the new MSc Cardiovascular Sciences postgraduate degree. In semester 1 the program covers evidence based biomedical research method, clinical and research laboratory skills, clinical aspects of cardiovascular disease (CVD) and diabetes. In semester 2 the course covers the basic science of CVD, tissues, cells and signaling and includes a 12 week laboratory based research project.

In addition I take students for basic science and engineering research projects across a number of undergraduate and masters programs including the integrated mammalian biology course (IMB-MRes and Meng schemes). I also contribute to a number of undergraduate lecture programs including Year 2 SSC research methods, Year 3 Human biology and Physiology - mitochondria in health, Year 4, Molecular basis of disease and the new Level 4 Mitochondrial option. I also coordinate the Level 4 Biochemistry Mitochondrial lab practical.

I am a fellow of the higher education authority (FHEA) and STEM Ambassador to promote science technology, engineering and maths at primary and secondary school level.