2024

Tobias, E. S. et al. (2024) SEC31A may be associated with pituitary hormone deficiency and gonadal dysgenesis. Endocrine, (doi: 10.1007/s12020-024-03701-x) (PMID:38400880) (Early Online Publication)

2023

Schigt, H. et al. (2023) Expanding the phenotypic spectrum of Kenny-Caffey syndrome: a case series and systematic literature review. Journal of Clinical Endocrinology and Metabolism, 108(9), e754-e768. (doi: 10.1210/clinem/dgad147) (PMID:36916904) (PMCID:PMC10438882)

de Sousa, J. A. C., Azul, F. V. C. S., de Araújo, A. B., Tomé, R. C., Silva, F. R. M., de Vasconcelos, S. M. M., Rios, F. J. and Leal, L. K. A. M. (2023) Epiisopiloturine, an alkaloid from Pilocarpus microphyllus, attenuates LPS-induced neuroinflammation by interfering in the TLR4/NF-κB-MAPK signaling pathway in microglial cells. Oxidative Medicine and Cellular Longevity, 2023, 4752502. (doi: 10.1155/2023/4752502) (PMID:37151606) (PMCID:PMC10162877)

2022

Gao, X. et al. (2022) Palmitoylation regulates cellular distribution of and transmembrane Ca flux through TrpM7. Cell Calcium, 106, 102639. (doi: 10.1016/j.ceca.2022.102639) (PMID:36027648)

Rios, F. J. et al. (2022) TRPM7 deficiency exacerbates cardiovascular and renal damage induced by aldosterone-salt. Communications Biology, 5, 746. (doi: 10.1038/s42003-022-03715-z) (PMID:35882956) (PMCID:PMC9325869)

Camargo, L. L. et al. (2022) Central role of c-Src in NOX5- mediated redox signaling in vascular smooth muscle cells in human hypertension. Cardiovascular Research, 118(5), pp. 1359-1373. (doi: 10.1093/cvr/cvab171) (PMID:34320175) (PMCID:PMC8953456)

Neves, K. B. , Rios, F. J. , Sevilla-Montero, J., Montezano, A. C. and Touyz, R. M. (2022) Exosomes and the cardiovascular system: role in cardiovascular health and disease. Journal of Physiology, (doi: 10.1113/JP282054) (PMID:35306667) (Early Online Publication)

2021

Touyz, R. M. et al. (2021) Cardiovascular and renal risk factors and complications associated with COVID-19. CJC Open, 3(10), pp. 1257-1272. (doi: 10.1016/j.cjco.2021.05.020) (PMID:34151246) (PMCID:PMC8205551)

Alves-Lopes, R. et al. (2021) Selective inhibition of the C-domain of ACE (angiotensin-converting enzyme) combined with inhibition of NEP (neprilysin): a potential new therapy for hypertension. Hypertension, 78(3), pp. 604-616. (doi: 10.1161/HYPERTENSIONAHA.121.17041) (PMID:34304582) (PMCID:PMC8357049)

Da Silva, J. F. et al. (2021) Lysophosphatidylcholine induces oxidative stress in human endothelial cells via NOX5 activation - implications in atherosclerosis. Clinical Science, 135(15), pp. 1845-1858. (doi: 10.1042/CS20210468) (PMID:34269800)

Wolf, F. I. et al. (2021) The magnesium global network (MaGNet) to promote research on magnesium in diseases focusing on covid-19. Magnesium Research, 34(2), pp. 90-92. (doi: 10.1684/mrh.2021.0479) (PMID:34524085)

Griendling, K. K., Camargo, L. L., Rios, F. , Alves-Lopes, R., Montezano, A. C. and Touyz, R. M. (2021) Oxidative stress and hypertension. Circulation Research, 128(7), pp. 993-1020. (doi: 10.1161/CIRCRESAHA.121.318063) (PMID:33793335)

2020

Cameron, A. C. et al. (2020) Comprehensive characterisation of the vascular effects of cisplatin-based chemotherapy in patients with testicular cancer. JACC: CardioOncology, 2(3), pp. 443-455. (doi: 10.1016/j.jaccao.2020.06.004) (PMID:33043304) (PMCID:PMC7539369)

Zou, Z.-G. et al. (2020) Epidermal growth factor signaling through transient receptor potential melastatin 7 cation channel regulates vascular smooth muscle cell function. Clinical Science, 134(15), pp. 2019-2035. (doi: 10.1042/CS20200827) (PMID:32706027) (PMCID:PMC8299307)

Touyz, R. , Rios, F. , Alves-Lopes, R., Neves, K. B. , De Lucca Camargo, L. and Montezano, A. C. (2020) Oxidative stress: a unifying paradigm in hypertension. Canadian Journal of Cardiology, 36, pp. 659-670. (doi: 10.1016/j.cjca.2020.02.081) (PMID:32389339) (PMCID:PMC7225748)

Rios, F. J. , Montezano, A. C. and Touyz, R. M. (2020) Lessons learned from RAG-1-deficient mice in hypertension. Hypertension, 75(4), pp. 935-937. (doi: 10.1161/hypertensionaha.119.14406) (PMID:32078397)

Rios, F. J. et al. (2020) Chanzyme TRPM7 protects against cardiovascular inflammation and fibrosis. Cardiovascular Research, 116(3), pp. 721-735. (doi: 10.1093/cvr/cvz164) (PMID:31250885) (PMCID:PMC7252442)

Alves-Lopes, R., Neves, K. B. , Anagnostopoulou, A., Rios, F. J. , Lacchini, S., Montezano, A. C. and Touyz, R. M. (2020) Crosstalk between vascular redox and calcium signaling in hypertension involves TRPM2 (Transient Receptor Potential Melastatin 2) cation channel. Hypertension, 75(1), pp. 139-149. (doi: 10.1161/hypertensionaha.119.13861) (PMID:31735084)

2019

Neves, K. B. et al. (2019) ER stress and Rho kinase activation underlie the vasculopathy of CADASIL. JCI Insight, 4(23), e131344. (doi: 10.1172/jci.insight.131344) (PMID:31647781) (PMCID:PMC6962020)

Touyz, R. M. , Anagnostopoulou, A., Rios, F. , Montezano, A. C. and De Lucca Camargo, L. (2019) NOX5: molecular biology and pathophysiology. Experimental Physiology, 104(5), pp. 605-616. (doi: 10.1113/EP086204) (PMID:30801870) (PMCID:PMC6519284)

Neves, K. B. , Rios, F. J. , Jones, R. , Evans, T. R. J. , Montezano, A. C. and Touyz, R. M. (2019) Microparticles from vascular endothelial growth factor pathway inhibitor-treated cancer patients mediate endothelial cell injury. Cardiovascular Research, 115(5), pp. 978-988. (doi: 10.1093/cvr/cvz021) (PMID:30753341) (PMCID:PMC6452312)

Zou, Z.-G., Rios, F. J. , Montezano, A. C. and Touyz, R. M. (2019) TRPM7, magnesium and signaling. International Journal of Molecular Sciences, 20(8), 1877. (doi: 10.3390/ijms20081877) (PMID:30995736) (PMCID:PMC6515203)

Touyz, R. M. , Anagnostopoulou, A., De Lucca Camargo, L. , Rios, F. J. and Montezano, A. C. (2019) Vascular biology of superoxide-generating NADPH oxidase 5 (Nox5)- implications in hypertension and cardiovascular disease. Antioxidants and Redox Signaling, 30(7), pp. 1027-1040. (doi: 10.1089/ars.2018.7583) (PMID:30334629) (PMCID:PMC6354601)

Kerr, D. M.I., Brooksbank, K. J.M., Taylor, R. G., Pinel, K., Rios, F. J. , Touyz, R. M. and Delles, C. (2019) Acute effects of electronic and tobacco cigarettes on vascular and respiratory function in healthy volunteers: a cross-over study. Journal of Hypertension, 37(1), pp. 154-166. (doi: 10.1097/HJH.0000000000001890) (PMID:30063637)

Rios, F. J. , Touyz, R. M. , Montezano, A. C. and Burger, D. (2019) Microparticles and exosomes in cell-cell communication. In: Touyz, R. M. and Delles, C. (eds.) Textbook of Vascular Medicine. Springer: Cham, pp. 159-168. ISBN 9783030164805 (doi: 10.1007/978-3-030-16481-2_15)

2018

Rios, F. J. , Moustaïd-Moussa, N. and Martins, J. O. (2018) Interplay between hormones, the immune system, and metabolic disorders. Mediators of Inflammation, 2018, 8654212. (doi: 10.1155/2018/8654212) (PMID:30363970) (PMCID:PMC6186352)

De Lucca Camargo, L. et al. (2018) Vascular Nox (NADPH oxidase) compartmentalization, protein hyperoxidation, and endoplasmic reticulum stress response in hypertension. Hypertension, 72(1), pp. 235-246. (doi: 10.1161/HYPERTENSIONAHA.118.10824) (PMID:29844144) (PMCID:PMC6004120)

Montezano, A. C. et al. (2018) NADPH oxidase 5 is a pro‐contractile Nox isoform and a point of cross‐talk for calcium and redox signaling‐implications in vascular function. Journal of the American Heart Association, 7(12), e009388. (doi: 10.1161/JAHA.118.009388) (PMID:29907654) (PMCID:PMC6220544)

Montezano, A. C. et al. (2018) NADPH Oxidase 5 is a pro‐contractile Nox isoform and a point of cross‐talk for calcium and redox signaling‐implications in vascular function. Journal of the American Heart Association, 7(12), (doi: 10.1161/JAHA.118.009388) (PMID:29907654) (PMCID:PMC6220544)

Neves, K. B. , Rios, F. J. , Van Der Mey, L., Alves-Lopes, R. , Cameron, A. C., Volpe, M., Montezano, A. C., Savoia, C. and Touyz, R. M. (2018) VEGFR (vascular endothelial growth factor receptor) inhibition induces cardiovascular damage via redox-sensitive processes. Hypertension, 71(4), pp. 638-647. (doi: 10.1161/HYPERTENSIONAHA.117.10490) (PMID:29483228)

Touyz, R. M. , Alves-Lopes, R. , Rios, F. J. , De Lucca Camargo, L. , Anagnostopoulou, A., Arner, A. and Montezano, A. C. (2018) Vascular smooth muscle contraction in hypertension. Cardiovascular Research, 114(4), pp. 529-539. (doi: 10.1093/cvr/cvy023) (PMID:29394331) (PMCID:PMC5852517)

2017

Skiba, D.S. et al. (2017) Anti‐atherosclerotic effect of the angiotensin 1–7 mimetic AVE0991 is mediated by inhibition of perivascular and plaque inflammation in early atherosclerosis. British Journal of Pharmacology, 174(22), pp. 4055-4069. (doi: 10.1111/bph.13685) (PMID:27935022) (PMCID:PMC5659999)

Harvey, A. P., Montezano, A. C., Hood, K. Y., Lopes, R. A. , Rios, F. , Ceravolo, G., Graham, D. and Touyz, R. M. (2017) Vascular dysfunction and fibrosis in stroke-prone spontaneously hypertensive rats: the aldosterone-mineralocorticoid receptor-Nox1 Axis. Life Sciences, 179, pp. 110-119. (doi: 10.1016/j.lfs.2017.05.002) (PMID:28478264) (PMCID:5446265)

Touyz, R. M. , Montezano, A. C., Rios, F. , Widlansky, M. E. and Liang, M. (2017) Redox stress defines the small artery vasculopathy of hypertension: how do we bridge the bench-to-bedside gap? Circulation Research, 120(11), pp. 1721-1723. (doi: 10.1161/CIRCRESAHA.117.310672) (PMID:28546356) (PMCID:PMC5520661)

Rios, F. J. , Touyz, R. M. and Montezano, A. C. (2017) Isolation and differentiation of human macrophages. In: Touyz, R. M. and Schiffrin, E. L. (eds.) Hypertension: Methods and Protocols. Series: Methods in molecular biology, 1527. Springer: New York, pp. 311-320. ISBN 9781493966233 (doi: 10.1007/978-1-4939-6625-7_24)

Montezano, A. C., Lopes, R. A.M. , Neves, K. B. , Rios, F. and Touyz, R. M. (2017) Isolation and culture of vascular smooth muscle cells from small and large vessels. In: Touyz, R. M. and Schiffrin, E. L. (eds.) Hypertension: Methods and Protocols. Series: Methods in molecular biology (1527). Springer: New York, pp. 349-354. ISBN 9781493966233 (doi: 10.1007/978-1-4939-6625-7_27)

Montezano, A. C., Neves, K. B. , Lopes, R. A.M. and Rios, F. (2017) Isolation and culture of endothelial cells from large vessels. In: Touyz, R. M. and Schiffrin, E. L. (eds.) Hypertension: Methods and Protocols. Series: Methods in molecular biology (1527). Springer: New York, pp. 345-348. ISBN 9781493966233 (doi: 10.1007/978-1-4939-6625-7_26)

Rios, F. J. , Touyz, R. M. and Montezano, A. C. (2017) Isolation and differentiation of murine macrophages. In: Touyz, R. M. and Shiffrin, E. L. (eds.) Hypertension: Methods and Protocols. Series: Methods in molecular biology. Humana Press, pp. 297-309. ISBN 9781493966233 (doi: 10.1007/978-1-4939-6625-7_23)

2016

Koga, M. M., Bizzarro, B., Sá-Nunes, A., Rios, F. J. and Jancar, S. (2016) Boosting adaptive immunity: a new role for PAFR antagonists. Scientific Reports, 6, 39146. (doi: 10.1038/srep39146) (PMID:27966635) (PMCID:PMC5155422)

Ishizuka, E. K., Filgueiras, L. R., Rios, F. J. , Serezani, C. H. and Jancar, S. (2016) PAFR activation of NF-κB p65 or p105 precursor dictates pro- and anti-inflammatory responses during TLR activation in murine macrophages. Scientific Reports, 6, 32092. (doi: 10.1038/srep32092) (PMID:27554194) (PMCID:PMC4995467)

Harvey, A., Montezano, A. C., Lopes, R. A. , Rios, F. and Touyz, R. (2016) Vascular fibrosis in aging and hypertension: molecular mechanisms and clinical implications. Canadian Journal of Cardiology, 32(5), pp. 659-668. (doi: 10.1016/j.cjca.2016.02.070) (PMID:27118293) (PMCID:PMC4906153)

Rios, F. J. , Lopes, R. A. , Neves, K. B., De Lucca Camargo, L. , Montezano, A. C. and Touyz, R. M. (2016) Off-target vascular effects of cholesteryl ester transfer protein inhibitors involve redox-sensitive and signal transducer and activator of transcription 3-dependent pathways. Journal of Pharmacology and Experimental Therapeutics, 357(2), pp. 415-422. (doi: 10.1124/jpet.115.230748) (PMID:26941168)

Rios, F. J. , Harvey, A., Lopes, R. A. , Montezano, A. C. and Touyz, R. (2016) Progenitor cells, bone marrow–derived fibrocytes and endothelial-to-mesenchymal transition: new players in vascular fibrosis. Hypertension, 67, pp. 272-274. (doi: 10.1161/HYPERTENSIONAHA.115.06220) (PMID:26693817)

Filgueiras, L. R., Koga, M. M., Quaresma, P. G., Ishizuka, E. K., Montes, M. B. A., Prada, P. O., Saad, M. J., Jancar, S. and Rios, F.J. (2016) PAFR in adipose tissue macrophages is associated with anti-inflammatory phenotype and metabolic homoeostasis. Clinical Science, 130(8), pp. 601-612. (doi: 10.1042/cs20150538) (PMID:26785675)

Rios, F. J. , Montezano, A. C., Antunes, T. T. and Touyz, R. M. (2016) Magnesium, vascular function, and hypertension. In: Collins, J. F. (ed.) Molecular, Genetic, and Nutritional Aspects of Major and Trace Minerals. Academic Press, pp. 353-364. ISBN 9780128021682 (doi: 10.1016/B978-0-12-802168-2.00029-4)

2015

Neves, K. B., Nguyen Dinh Cat, A., Lopes, R. A. M., Rios, F. J. , Anagnostopoulou, A., Lobato, N. S., de Oliveira, A. M., Tostes, R. C., Montezano, A. C. and Touyz, R. M. (2015) Chemerin regulates crosstalk between adipocytes and vascular cells through Nox. Hypertension, 66(3), pp. 657-666. (doi: 10.1161/HYPERTENSIONAHA.115.05616) (PMID:26150435)

Rios, F. , Neves, K. B., Nguyen Dinh Cat, A., Even, S., Palacios, R. , Montezano, A. C. and Touyz, R. (2015) Cholesteryl ester-transfer protein inhibitors stimulate aldosterone biosynthesis in adipocytes through nox-dependent processes. Journal of Pharmacology and Experimental Therapeutics, 353(1), pp. 27-34. (doi: 10.1124/jpet.114.221002) (PMID:25617244)

Bachi, A. L. L., Rios, F. J.O. , Vaisberg, P. H. C., Martins, M., Cavalcante de Sá, M., Victorino, A. B., Foster, R., Sierra, A. P. R., Dal'Molin Kiss, M. A. P. and Vaisberg, M. (2015) Neuro-immuno-endocrine modulation in marathon runners. Neuroimmunomodulation, 22(3), pp. 196-202. (doi: 10.1159/000363061)

Welsh, P. , Preiss, D. , Tsiropoulou, S., Rios, F. J. , Harvey, A., Dulak-Lis, M. G., Montezano, A. C. and Touyz, R. M. (2015) Biomarkers of vascular inflammation and cardiovascular disease. In: Berbari, A. and Mancia, G. (eds.) Arterial Disorders: Definition, Clinical Manifestations, Mechanisms and Therapeutic Approaches. Springer: Cham, pp. 115-136. ISBN 9783319145556 (doi: 10.1007/978-3-319-14556-3_9)

2014

Touyz, R. M. , Montezano, A. C., Rios, F. J. and Savoia, C. (2014) Reply to letter by McIntyre et al. Canadian Journal of Cardiology, 30(12), 1733.e3. (doi: 10.1016/j.cjca.2014.10.004)

Johansson, M. E. et al. (2014) Innate immune receptor NOD2 promotes vascular inflammation and formation of lipid-rich necrotic cores in hypercholesterolemic mice. European Journal of Immunology, 44(10), pp. 3081-3092. (doi: 10.1002/eji.201444755) (PMID:25042478)

Small, H. Y., Montezano, A. C., Rios, F. J. , Savoia, C. and Touyz, R. M. (2014) Hypertension due to antiangiogenic cancer therapy with vascular endothelial growth factor inhibitors: understanding and managing a new syndrome. Canadian Journal of Cardiology, 30(5), pp. 534-543. (doi: 10.1016/j.cjca.2014.02.011)

Montezano, A. C., Nguyen Dinh Cat, A., Rios, F. J. and Touyz, R. M. (2014) Angiotensin II and vascular injury. Current Hypertension Reports, 16(6), p. 431. (doi: 10.1007/s11906-014-0431-2)

Correa-Costa, M. et al. (2014) Activation of platelet-activating factor receptor exacerbates renal inflammation and promotes fibrosis. Laboratory Investigation, 94(4), pp. 455-466. (doi: 10.1038/labinvest.2013.155)

2013

Even, S. et al. (2013) The Nox4 inhibitor GKT137831, prevents aldosterone production by adipocytes and protects against adipose tissue inflammation and fibrosis in obese mice. Hypertension, 62(3 Sup), A74.

Rios, F. J. , Nguyen Dinh Cat, A., Palacios, R. , Carswell, A., Montezano, A. C. and Touyz, R. M. (2013) Torcetrapib and dalcetrapib, CETP inhibitors, induce adipocyte-derived aldosterone and reactive oxygen species formation. Hypertension, 62(3 Sup), A356.

Ferracini, M., Rios, F.J.O. , Pecenin, M. and Jancar, S. (2013) Clearance of apoptotic cells by macrophages induces regulatory phenotype and involves stimulation of cd36 and platelet-activating factor receptor. Mediators of Inflammation, 2013, p. 950273. (doi: 10.1155/2013/950273)

Rios, F.J. , Koga, M.M., Pecenin, M., Ferracini, M., Gidlund, M. and Jancar, S. (2013) Oxidized LDL induces alternative macrophage phenotype through activation of CD36 and PAFR. Mediators of Inflammation, 2013, p. 198193. (doi: 10.1155/2013/198193)

Rios, F.J.O. , Ferracini, M., Pecenin, M., Koga, M.M., Wang, Y., Ketelhuth, D.F.J. and Jancar, S. (2013) Uptake of oxLDL and IL-10 production by macrophages requires PAFR and CD36 recruitment into the same lipid rafts. PLoS ONE, 8(10), e76893. (doi: 10.1371/journal.pone.0076893) (PMID:24130805) (PMCID:PMC3793910)

Articles

Tobias, E. S. et al. (2024) SEC31A may be associated with pituitary hormone deficiency and gonadal dysgenesis. Endocrine, (doi: 10.1007/s12020-024-03701-x) (PMID:38400880) (Early Online Publication)

Schigt, H. et al. (2023) Expanding the phenotypic spectrum of Kenny-Caffey syndrome: a case series and systematic literature review. Journal of Clinical Endocrinology and Metabolism, 108(9), e754-e768. (doi: 10.1210/clinem/dgad147) (PMID:36916904) (PMCID:PMC10438882)

de Sousa, J. A. C., Azul, F. V. C. S., de Araújo, A. B., Tomé, R. C., Silva, F. R. M., de Vasconcelos, S. M. M., Rios, F. J. and Leal, L. K. A. M. (2023) Epiisopiloturine, an alkaloid from Pilocarpus microphyllus, attenuates LPS-induced neuroinflammation by interfering in the TLR4/NF-κB-MAPK signaling pathway in microglial cells. Oxidative Medicine and Cellular Longevity, 2023, 4752502. (doi: 10.1155/2023/4752502) (PMID:37151606) (PMCID:PMC10162877)

Gao, X. et al. (2022) Palmitoylation regulates cellular distribution of and transmembrane Ca flux through TrpM7. Cell Calcium, 106, 102639. (doi: 10.1016/j.ceca.2022.102639) (PMID:36027648)

Rios, F. J. et al. (2022) TRPM7 deficiency exacerbates cardiovascular and renal damage induced by aldosterone-salt. Communications Biology, 5, 746. (doi: 10.1038/s42003-022-03715-z) (PMID:35882956) (PMCID:PMC9325869)

Camargo, L. L. et al. (2022) Central role of c-Src in NOX5- mediated redox signaling in vascular smooth muscle cells in human hypertension. Cardiovascular Research, 118(5), pp. 1359-1373. (doi: 10.1093/cvr/cvab171) (PMID:34320175) (PMCID:PMC8953456)

Neves, K. B. , Rios, F. J. , Sevilla-Montero, J., Montezano, A. C. and Touyz, R. M. (2022) Exosomes and the cardiovascular system: role in cardiovascular health and disease. Journal of Physiology, (doi: 10.1113/JP282054) (PMID:35306667) (Early Online Publication)

Touyz, R. M. et al. (2021) Cardiovascular and renal risk factors and complications associated with COVID-19. CJC Open, 3(10), pp. 1257-1272. (doi: 10.1016/j.cjco.2021.05.020) (PMID:34151246) (PMCID:PMC8205551)

Alves-Lopes, R. et al. (2021) Selective inhibition of the C-domain of ACE (angiotensin-converting enzyme) combined with inhibition of NEP (neprilysin): a potential new therapy for hypertension. Hypertension, 78(3), pp. 604-616. (doi: 10.1161/HYPERTENSIONAHA.121.17041) (PMID:34304582) (PMCID:PMC8357049)

Da Silva, J. F. et al. (2021) Lysophosphatidylcholine induces oxidative stress in human endothelial cells via NOX5 activation - implications in atherosclerosis. Clinical Science, 135(15), pp. 1845-1858. (doi: 10.1042/CS20210468) (PMID:34269800)

Wolf, F. I. et al. (2021) The magnesium global network (MaGNet) to promote research on magnesium in diseases focusing on covid-19. Magnesium Research, 34(2), pp. 90-92. (doi: 10.1684/mrh.2021.0479) (PMID:34524085)

Griendling, K. K., Camargo, L. L., Rios, F. , Alves-Lopes, R., Montezano, A. C. and Touyz, R. M. (2021) Oxidative stress and hypertension. Circulation Research, 128(7), pp. 993-1020. (doi: 10.1161/CIRCRESAHA.121.318063) (PMID:33793335)

Cameron, A. C. et al. (2020) Comprehensive characterisation of the vascular effects of cisplatin-based chemotherapy in patients with testicular cancer. JACC: CardioOncology, 2(3), pp. 443-455. (doi: 10.1016/j.jaccao.2020.06.004) (PMID:33043304) (PMCID:PMC7539369)

Zou, Z.-G. et al. (2020) Epidermal growth factor signaling through transient receptor potential melastatin 7 cation channel regulates vascular smooth muscle cell function. Clinical Science, 134(15), pp. 2019-2035. (doi: 10.1042/CS20200827) (PMID:32706027) (PMCID:PMC8299307)

Touyz, R. , Rios, F. , Alves-Lopes, R., Neves, K. B. , De Lucca Camargo, L. and Montezano, A. C. (2020) Oxidative stress: a unifying paradigm in hypertension. Canadian Journal of Cardiology, 36, pp. 659-670. (doi: 10.1016/j.cjca.2020.02.081) (PMID:32389339) (PMCID:PMC7225748)

Rios, F. J. , Montezano, A. C. and Touyz, R. M. (2020) Lessons learned from RAG-1-deficient mice in hypertension. Hypertension, 75(4), pp. 935-937. (doi: 10.1161/hypertensionaha.119.14406) (PMID:32078397)

Rios, F. J. et al. (2020) Chanzyme TRPM7 protects against cardiovascular inflammation and fibrosis. Cardiovascular Research, 116(3), pp. 721-735. (doi: 10.1093/cvr/cvz164) (PMID:31250885) (PMCID:PMC7252442)

Alves-Lopes, R., Neves, K. B. , Anagnostopoulou, A., Rios, F. J. , Lacchini, S., Montezano, A. C. and Touyz, R. M. (2020) Crosstalk between vascular redox and calcium signaling in hypertension involves TRPM2 (Transient Receptor Potential Melastatin 2) cation channel. Hypertension, 75(1), pp. 139-149. (doi: 10.1161/hypertensionaha.119.13861) (PMID:31735084)

Neves, K. B. et al. (2019) ER stress and Rho kinase activation underlie the vasculopathy of CADASIL. JCI Insight, 4(23), e131344. (doi: 10.1172/jci.insight.131344) (PMID:31647781) (PMCID:PMC6962020)

Touyz, R. M. , Anagnostopoulou, A., Rios, F. , Montezano, A. C. and De Lucca Camargo, L. (2019) NOX5: molecular biology and pathophysiology. Experimental Physiology, 104(5), pp. 605-616. (doi: 10.1113/EP086204) (PMID:30801870) (PMCID:PMC6519284)

Neves, K. B. , Rios, F. J. , Jones, R. , Evans, T. R. J. , Montezano, A. C. and Touyz, R. M. (2019) Microparticles from vascular endothelial growth factor pathway inhibitor-treated cancer patients mediate endothelial cell injury. Cardiovascular Research, 115(5), pp. 978-988. (doi: 10.1093/cvr/cvz021) (PMID:30753341) (PMCID:PMC6452312)

Zou, Z.-G., Rios, F. J. , Montezano, A. C. and Touyz, R. M. (2019) TRPM7, magnesium and signaling. International Journal of Molecular Sciences, 20(8), 1877. (doi: 10.3390/ijms20081877) (PMID:30995736) (PMCID:PMC6515203)

Touyz, R. M. , Anagnostopoulou, A., De Lucca Camargo, L. , Rios, F. J. and Montezano, A. C. (2019) Vascular biology of superoxide-generating NADPH oxidase 5 (Nox5)- implications in hypertension and cardiovascular disease. Antioxidants and Redox Signaling, 30(7), pp. 1027-1040. (doi: 10.1089/ars.2018.7583) (PMID:30334629) (PMCID:PMC6354601)

Kerr, D. M.I., Brooksbank, K. J.M., Taylor, R. G., Pinel, K., Rios, F. J. , Touyz, R. M. and Delles, C. (2019) Acute effects of electronic and tobacco cigarettes on vascular and respiratory function in healthy volunteers: a cross-over study. Journal of Hypertension, 37(1), pp. 154-166. (doi: 10.1097/HJH.0000000000001890) (PMID:30063637)

Rios, F. J. , Moustaïd-Moussa, N. and Martins, J. O. (2018) Interplay between hormones, the immune system, and metabolic disorders. Mediators of Inflammation, 2018, 8654212. (doi: 10.1155/2018/8654212) (PMID:30363970) (PMCID:PMC6186352)

De Lucca Camargo, L. et al. (2018) Vascular Nox (NADPH oxidase) compartmentalization, protein hyperoxidation, and endoplasmic reticulum stress response in hypertension. Hypertension, 72(1), pp. 235-246. (doi: 10.1161/HYPERTENSIONAHA.118.10824) (PMID:29844144) (PMCID:PMC6004120)

Montezano, A. C. et al. (2018) NADPH oxidase 5 is a pro‐contractile Nox isoform and a point of cross‐talk for calcium and redox signaling‐implications in vascular function. Journal of the American Heart Association, 7(12), e009388. (doi: 10.1161/JAHA.118.009388) (PMID:29907654) (PMCID:PMC6220544)

Montezano, A. C. et al. (2018) NADPH Oxidase 5 is a pro‐contractile Nox isoform and a point of cross‐talk for calcium and redox signaling‐implications in vascular function. Journal of the American Heart Association, 7(12), (doi: 10.1161/JAHA.118.009388) (PMID:29907654) (PMCID:PMC6220544)

Neves, K. B. , Rios, F. J. , Van Der Mey, L., Alves-Lopes, R. , Cameron, A. C., Volpe, M., Montezano, A. C., Savoia, C. and Touyz, R. M. (2018) VEGFR (vascular endothelial growth factor receptor) inhibition induces cardiovascular damage via redox-sensitive processes. Hypertension, 71(4), pp. 638-647. (doi: 10.1161/HYPERTENSIONAHA.117.10490) (PMID:29483228)

Touyz, R. M. , Alves-Lopes, R. , Rios, F. J. , De Lucca Camargo, L. , Anagnostopoulou, A., Arner, A. and Montezano, A. C. (2018) Vascular smooth muscle contraction in hypertension. Cardiovascular Research, 114(4), pp. 529-539. (doi: 10.1093/cvr/cvy023) (PMID:29394331) (PMCID:PMC5852517)

Skiba, D.S. et al. (2017) Anti‐atherosclerotic effect of the angiotensin 1–7 mimetic AVE0991 is mediated by inhibition of perivascular and plaque inflammation in early atherosclerosis. British Journal of Pharmacology, 174(22), pp. 4055-4069. (doi: 10.1111/bph.13685) (PMID:27935022) (PMCID:PMC5659999)

Harvey, A. P., Montezano, A. C., Hood, K. Y., Lopes, R. A. , Rios, F. , Ceravolo, G., Graham, D. and Touyz, R. M. (2017) Vascular dysfunction and fibrosis in stroke-prone spontaneously hypertensive rats: the aldosterone-mineralocorticoid receptor-Nox1 Axis. Life Sciences, 179, pp. 110-119. (doi: 10.1016/j.lfs.2017.05.002) (PMID:28478264) (PMCID:5446265)

Touyz, R. M. , Montezano, A. C., Rios, F. , Widlansky, M. E. and Liang, M. (2017) Redox stress defines the small artery vasculopathy of hypertension: how do we bridge the bench-to-bedside gap? Circulation Research, 120(11), pp. 1721-1723. (doi: 10.1161/CIRCRESAHA.117.310672) (PMID:28546356) (PMCID:PMC5520661)

Koga, M. M., Bizzarro, B., Sá-Nunes, A., Rios, F. J. and Jancar, S. (2016) Boosting adaptive immunity: a new role for PAFR antagonists. Scientific Reports, 6, 39146. (doi: 10.1038/srep39146) (PMID:27966635) (PMCID:PMC5155422)

Ishizuka, E. K., Filgueiras, L. R., Rios, F. J. , Serezani, C. H. and Jancar, S. (2016) PAFR activation of NF-κB p65 or p105 precursor dictates pro- and anti-inflammatory responses during TLR activation in murine macrophages. Scientific Reports, 6, 32092. (doi: 10.1038/srep32092) (PMID:27554194) (PMCID:PMC4995467)

Harvey, A., Montezano, A. C., Lopes, R. A. , Rios, F. and Touyz, R. (2016) Vascular fibrosis in aging and hypertension: molecular mechanisms and clinical implications. Canadian Journal of Cardiology, 32(5), pp. 659-668. (doi: 10.1016/j.cjca.2016.02.070) (PMID:27118293) (PMCID:PMC4906153)

Rios, F. J. , Lopes, R. A. , Neves, K. B., De Lucca Camargo, L. , Montezano, A. C. and Touyz, R. M. (2016) Off-target vascular effects of cholesteryl ester transfer protein inhibitors involve redox-sensitive and signal transducer and activator of transcription 3-dependent pathways. Journal of Pharmacology and Experimental Therapeutics, 357(2), pp. 415-422. (doi: 10.1124/jpet.115.230748) (PMID:26941168)

Rios, F. J. , Harvey, A., Lopes, R. A. , Montezano, A. C. and Touyz, R. (2016) Progenitor cells, bone marrow–derived fibrocytes and endothelial-to-mesenchymal transition: new players in vascular fibrosis. Hypertension, 67, pp. 272-274. (doi: 10.1161/HYPERTENSIONAHA.115.06220) (PMID:26693817)

Filgueiras, L. R., Koga, M. M., Quaresma, P. G., Ishizuka, E. K., Montes, M. B. A., Prada, P. O., Saad, M. J., Jancar, S. and Rios, F.J. (2016) PAFR in adipose tissue macrophages is associated with anti-inflammatory phenotype and metabolic homoeostasis. Clinical Science, 130(8), pp. 601-612. (doi: 10.1042/cs20150538) (PMID:26785675)

Neves, K. B., Nguyen Dinh Cat, A., Lopes, R. A. M., Rios, F. J. , Anagnostopoulou, A., Lobato, N. S., de Oliveira, A. M., Tostes, R. C., Montezano, A. C. and Touyz, R. M. (2015) Chemerin regulates crosstalk between adipocytes and vascular cells through Nox. Hypertension, 66(3), pp. 657-666. (doi: 10.1161/HYPERTENSIONAHA.115.05616) (PMID:26150435)

Rios, F. , Neves, K. B., Nguyen Dinh Cat, A., Even, S., Palacios, R. , Montezano, A. C. and Touyz, R. (2015) Cholesteryl ester-transfer protein inhibitors stimulate aldosterone biosynthesis in adipocytes through nox-dependent processes. Journal of Pharmacology and Experimental Therapeutics, 353(1), pp. 27-34. (doi: 10.1124/jpet.114.221002) (PMID:25617244)

Bachi, A. L. L., Rios, F. J.O. , Vaisberg, P. H. C., Martins, M., Cavalcante de Sá, M., Victorino, A. B., Foster, R., Sierra, A. P. R., Dal'Molin Kiss, M. A. P. and Vaisberg, M. (2015) Neuro-immuno-endocrine modulation in marathon runners. Neuroimmunomodulation, 22(3), pp. 196-202. (doi: 10.1159/000363061)

Touyz, R. M. , Montezano, A. C., Rios, F. J. and Savoia, C. (2014) Reply to letter by McIntyre et al. Canadian Journal of Cardiology, 30(12), 1733.e3. (doi: 10.1016/j.cjca.2014.10.004)

Johansson, M. E. et al. (2014) Innate immune receptor NOD2 promotes vascular inflammation and formation of lipid-rich necrotic cores in hypercholesterolemic mice. European Journal of Immunology, 44(10), pp. 3081-3092. (doi: 10.1002/eji.201444755) (PMID:25042478)

Small, H. Y., Montezano, A. C., Rios, F. J. , Savoia, C. and Touyz, R. M. (2014) Hypertension due to antiangiogenic cancer therapy with vascular endothelial growth factor inhibitors: understanding and managing a new syndrome. Canadian Journal of Cardiology, 30(5), pp. 534-543. (doi: 10.1016/j.cjca.2014.02.011)

Montezano, A. C., Nguyen Dinh Cat, A., Rios, F. J. and Touyz, R. M. (2014) Angiotensin II and vascular injury. Current Hypertension Reports, 16(6), p. 431. (doi: 10.1007/s11906-014-0431-2)

Correa-Costa, M. et al. (2014) Activation of platelet-activating factor receptor exacerbates renal inflammation and promotes fibrosis. Laboratory Investigation, 94(4), pp. 455-466. (doi: 10.1038/labinvest.2013.155)

Even, S. et al. (2013) The Nox4 inhibitor GKT137831, prevents aldosterone production by adipocytes and protects against adipose tissue inflammation and fibrosis in obese mice. Hypertension, 62(3 Sup), A74.

Rios, F. J. , Nguyen Dinh Cat, A., Palacios, R. , Carswell, A., Montezano, A. C. and Touyz, R. M. (2013) Torcetrapib and dalcetrapib, CETP inhibitors, induce adipocyte-derived aldosterone and reactive oxygen species formation. Hypertension, 62(3 Sup), A356.

Ferracini, M., Rios, F.J.O. , Pecenin, M. and Jancar, S. (2013) Clearance of apoptotic cells by macrophages induces regulatory phenotype and involves stimulation of cd36 and platelet-activating factor receptor. Mediators of Inflammation, 2013, p. 950273. (doi: 10.1155/2013/950273)

Rios, F.J. , Koga, M.M., Pecenin, M., Ferracini, M., Gidlund, M. and Jancar, S. (2013) Oxidized LDL induces alternative macrophage phenotype through activation of CD36 and PAFR. Mediators of Inflammation, 2013, p. 198193. (doi: 10.1155/2013/198193)

Rios, F.J.O. , Ferracini, M., Pecenin, M., Koga, M.M., Wang, Y., Ketelhuth, D.F.J. and Jancar, S. (2013) Uptake of oxLDL and IL-10 production by macrophages requires PAFR and CD36 recruitment into the same lipid rafts. PLoS ONE, 8(10), e76893. (doi: 10.1371/journal.pone.0076893) (PMID:24130805) (PMCID:PMC3793910)

Book Sections

Rios, F. J. , Touyz, R. M. , Montezano, A. C. and Burger, D. (2019) Microparticles and exosomes in cell-cell communication. In: Touyz, R. M. and Delles, C. (eds.) Textbook of Vascular Medicine. Springer: Cham, pp. 159-168. ISBN 9783030164805 (doi: 10.1007/978-3-030-16481-2_15)

Rios, F. J. , Touyz, R. M. and Montezano, A. C. (2017) Isolation and differentiation of human macrophages. In: Touyz, R. M. and Schiffrin, E. L. (eds.) Hypertension: Methods and Protocols. Series: Methods in molecular biology, 1527. Springer: New York, pp. 311-320. ISBN 9781493966233 (doi: 10.1007/978-1-4939-6625-7_24)

Montezano, A. C., Lopes, R. A.M. , Neves, K. B. , Rios, F. and Touyz, R. M. (2017) Isolation and culture of vascular smooth muscle cells from small and large vessels. In: Touyz, R. M. and Schiffrin, E. L. (eds.) Hypertension: Methods and Protocols. Series: Methods in molecular biology (1527). Springer: New York, pp. 349-354. ISBN 9781493966233 (doi: 10.1007/978-1-4939-6625-7_27)

Montezano, A. C., Neves, K. B. , Lopes, R. A.M. and Rios, F. (2017) Isolation and culture of endothelial cells from large vessels. In: Touyz, R. M. and Schiffrin, E. L. (eds.) Hypertension: Methods and Protocols. Series: Methods in molecular biology (1527). Springer: New York, pp. 345-348. ISBN 9781493966233 (doi: 10.1007/978-1-4939-6625-7_26)

Rios, F. J. , Touyz, R. M. and Montezano, A. C. (2017) Isolation and differentiation of murine macrophages. In: Touyz, R. M. and Shiffrin, E. L. (eds.) Hypertension: Methods and Protocols. Series: Methods in molecular biology. Humana Press, pp. 297-309. ISBN 9781493966233 (doi: 10.1007/978-1-4939-6625-7_23)

Rios, F. J. , Montezano, A. C., Antunes, T. T. and Touyz, R. M. (2016) Magnesium, vascular function, and hypertension. In: Collins, J. F. (ed.) Molecular, Genetic, and Nutritional Aspects of Major and Trace Minerals. Academic Press, pp. 353-364. ISBN 9780128021682 (doi: 10.1016/B978-0-12-802168-2.00029-4)

Welsh, P. , Preiss, D. , Tsiropoulou, S., Rios, F. J. , Harvey, A., Dulak-Lis, M. G., Montezano, A. C. and Touyz, R. M. (2015) Biomarkers of vascular inflammation and cardiovascular disease. In: Berbari, A. and Mancia, G. (eds.) Arterial Disorders: Definition, Clinical Manifestations, Mechanisms and Therapeutic Approaches. Springer: Cham, pp. 115-136. ISBN 9783319145556 (doi: 10.1007/978-3-319-14556-3_9)