Mrs Jenna Nichols
- Affiliate Researcher (School of Biodiversity, One Health & Veterinary Medicine)
Publications
2024
Chan, B., Nuismer, S. L., Alqirbi, H., Nichols, J. , Remien, C. H., Davison, A. J. , Jarvis, M. A. and Redwood, A. J. (2024) Fine-tuning the evolutionary stability of recombinant herpesviral transmissible vaccines. Proceedings of the Royal Society B: Biological Sciences, 291(2034), 20241827. (doi: 10.1098/rspb.2024.1827) (PMID:39532136) (PMCID:PMC11557244)
Herder, V. et al. (2024) Correlates of disease severity in bluetongue as a model of acute arbovirus infection. PLoS Pathogens, 20(8), e1012466. (doi: 10.1371/journal.ppat.1012466) (PMID:39150989) (PMCID:PMC11357116)
Bangura, U. et al. (2024) Spatio-temporal spread of Lassa virus and a new rodent host in the Mano River Union area, West Africa. Emerging Microbes and Infections, 13(1), 2290834. (doi: 10.1080/22221751.2023.2290834) (PMID:38047354) (PMCID:PMC10919312)
Herder, V. et al. (2024) A machine learning framework to identify the correlates of disease severity in acute arbovirus infection. bioRxiv, (doi: 10.1101/2024.02.23.581333)
Gonzalo Nadal, V. et al. (2024) Suspected tick-borne flavivirus meningoencephalomyelitis in dogs from the UK: six cases (2021). Journal of Small Animal Practice, 65(2), pp. 132-143. (doi: 10.1111/jsap.13682) (PMID:37956993)
2023
Rubina, A. et al. (2023) ADAM17 targeting by human cytomegalovirus remodels the cell surface proteome to simultaneously regulate multiple immune pathways. Proceedings of the National Academy of Sciences of the United States of America, 120(33), e2303155120. (doi: 10.1073/pnas.2303155120) (PMID:37561786) (PMCID:PMC10438378)
Lista, M. J. et al. (2023) Strain-dependent restriction of human cytomegalovirus by zinc finger antiviral proteins. Journal of Virology, 97(3), e0184622. (doi: 10.1128/jvi.01846-22) (PMID:36916924) (PMCID:PMC10062169)
Whitlock, A. O. B. et al. (2023) Identifying the genetic basis of viral spillover using Lassa virus as a test case. Royal Society Open Science, 10(3), 221503. (doi: 10.1098/rsos.221503) (PMID:36968239) (PMCID:PMC10031424)
Tong, L., Smollett, K. , Kwok, K. , Nomikou, K. , Galarion, M. J., Mair, D. , Filipe, A. and Nichols, J. (2023) Discovery of RNA and DNA viruses using next-generation sequencing: Metagenomics V.1. [Protocols]
Tong, L., Smollett, K. , Kwok, K. , Nomikou, K. , Galarion, M. J., Mair, D. , Filipe, A. and Nichols, J. (2023) Discovery of RNA and DNA viruses using next-generation sequencing: Targeted enrichment. [Protocols]
2022
Smollett, K. , Tong, L., Nomikou, K. , Nichols, J. , Kwok, K. , Galarion, M. J., Mair, D. and Filipe, A. (2022) Library clean up and quality control for Illumina sequencing. [Protocols]
Vucak, M. et al. (2022) Genome sequences of five arenaviruses from pygmy mice (Mus minutoides) in Sierra Leone. Microbiology Resource Announcements, 11(5), e0009522. (doi: 10.1128/mra.00095-22) (PMID:35389260) (PMCID:PMC9119099)
Aggarwal, D. et al. (2022) Genomic assessment of quarantine measures to prevent SARS-CoV-2 importation and transmission. Nature Communications, 13, 1012. (doi: 10.1038/s41467-022-28371-z) (PMID:35197443) (PMCID:PMC8866425)
Aggarwal, D. et al. (2022) Genomic epidemiology of SARS-CoV-2 in a UK university identifies dynamics of transmission. Nature Communications, 13, 751. (doi: 10.1038/s41467-021-27942-w) (PMID:35136068) (PMCID:PMC8826310)
Nightingale, K. et al. (2022) Human cytomegalovirus protein RL1 degrades the antiviral factor SLFN11 via recruitment of the CRL4 E3 ubiquitin ligase complex. Proceedings of the National Academy of Sciences of the United States of America, 119(6), e2108173119. (doi: 10.1073/pnas.2108173119) (PMID:35105802) (PMCID:PMC8832970)
Twohig, K. A. et al. (2022) Hospital admission and emergency care attendance risk for SARS-CoV-2 delta (B.1.617.2) compared with alpha (B.1.1.7) variants of concern: a cohort study. Lancet Infectious Diseases, 22(1), pp. 35-42. (doi: 10.1016/S1473-3099(21)00475-8) (PMID:34461056) (PMCID:PMC8397301)
2021
Vöhringer, H. S. et al. (2021) Genomic reconstruction of the SARS-CoV-2 epidemic in England. Nature, 600(7889), pp. 506-511. (doi: 10.1038/s41586-021-04069-y) (PMID:34649268) (PMCID:PMC8674138)
Herder, V. et al. (2021) Elevated temperature inhibits SARS-CoV-2 replication in respiratory epithelium independently of IFN-mediated innate immune defences. PLoS Biology, 19(12), e3001065. (doi: 10.1371/journal.pbio.3001065) (PMID:34932557) (PMCID:PMC8765667)
Wood, M. L. et al. (2021) Variation in human herpesvirus 6B telomeric integration, excision and transmission between tissues and individuals. eLife, 10, e70452. (doi: 10.7554/eLife.70452) (PMID:34545807) (PMCID:PMC8492063)
Li, K. K. et al. (2021) Genetic epidemiology of SARS-CoV-2 transmission in renal dialysis units - a high risk community-hospital interface. Journal of Infection, 83(1), pp. 96-103. (doi: 10.1016/j.jinf.2021.04.020) (PMID:33895226) (PMCID:PMC8061788)
Graham, M. S. et al. (2021) Changes in symptomatology, reinfection, and transmissibility associated with the SARS-CoV-2 variant B.1.1.7: an ecological study. Lancet Public Health, 6(5), e335-e345. (doi: 10.1016/S2468-2667(21)00055-4)
Volz, E. et al. (2021) Assessing transmissibility of SARS-CoV-2 lineage B.1.1.7 in England. Nature, 593(7858), pp. 266-269. (doi: 10.1038/s41586-021-03470-x) (PMID:33767447)
Thomson, E. C. et al. (2021) Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity. Cell, 184(5), 1171-1187.e20. (doi: 10.1016/j.cell.2021.01.037) (PMID:33621484) (PMCID:PMC7843029)
Rihn, S. J. et al. (2021) A plasmid DNA-launched SARS-CoV-2 reverse genetics system and coronavirus toolkit for COVID-19 research. PLoS Biology, 19(2), e3001091. (doi: 10.1371/journal.pbio.3001091) (PMID:33630831) (PMCID:PMC7906417)
Al Qaffas, A., Nichols, J. , Davison, A. J. , Ourahmane, A., Hertel, L., McVoy, M. A. and Camiolo, S. (2021) LoReTTA, a user-friendly tool for assembling viral genomes from PacBio sequence data. Virus Evolution, 7(1), veab042. (doi: 10.1093/ve/veab042) (PMID:33996146) (PMCID:PMC8111061)
Da Silva Filipe, A. et al. (2021) Genomic epidemiology reveals multiple introductions of SARS-CoV-2 from mainland Europe into Scotland. Nature Microbiology, 6(1), pp. 112-122. (doi: 10.1038/s41564-020-00838-z) (PMID:33349681)
Parker, M. D. et al. (2021) Subgenomic RNA identification in SARS-CoV-2 genomic sequencing data. Genome Research, 31, pp. 645-658. (doi: 10.1101/gr.268110.120) (PMID:33722935) (PMCID:PMC8015849)
2020
Fletcher-Etherlington, A., Nobre, L., Nightingale, K., Antrobus, R., Nichols, J. , Davison, A. J. , Stanton, R. J. and Weekes, M. P. (2020) Human cytomegalovirus protein pUL36: a dual cell death pathway inhibitor. Proceedings of the National Academy of Sciences of the United States of America, 117(31), pp. 18771-18779. (doi: 10.1073/pnas.2001887117) (PMID:32690704)
Al Qaffas, A., Camiolo, S. , Nichols, J. , Davison, A. J. , Ourahmane, A., Cui, X., Schleiss, M. R., Hertel, L., Dittmer, D. P. and McVoy, M. A. (2020) Genome sequence of human cytomegalovirus Ig-KG-H2, a variant of strain KG propagated in the presence of neutralizing antibodies. Microbiology Resource Announcements, 9(17), e00063-20. (doi: 10.1128/MRA.00063-20) (PMID:32327516) (PMCID:PMC7180270)
2019
Nobre, L. V. et al. (2019) Human cytomegalovirus interactome analysis identifies degradation hubs, domain associations and viral protein functions. eLife, 8, e49894. (doi: 10.7554/elife.49894) (PMID:31873071) (PMCID:PMC6959991)
Articles
Chan, B., Nuismer, S. L., Alqirbi, H., Nichols, J. , Remien, C. H., Davison, A. J. , Jarvis, M. A. and Redwood, A. J. (2024) Fine-tuning the evolutionary stability of recombinant herpesviral transmissible vaccines. Proceedings of the Royal Society B: Biological Sciences, 291(2034), 20241827. (doi: 10.1098/rspb.2024.1827) (PMID:39532136) (PMCID:PMC11557244)
Herder, V. et al. (2024) Correlates of disease severity in bluetongue as a model of acute arbovirus infection. PLoS Pathogens, 20(8), e1012466. (doi: 10.1371/journal.ppat.1012466) (PMID:39150989) (PMCID:PMC11357116)
Bangura, U. et al. (2024) Spatio-temporal spread of Lassa virus and a new rodent host in the Mano River Union area, West Africa. Emerging Microbes and Infections, 13(1), 2290834. (doi: 10.1080/22221751.2023.2290834) (PMID:38047354) (PMCID:PMC10919312)
Herder, V. et al. (2024) A machine learning framework to identify the correlates of disease severity in acute arbovirus infection. bioRxiv, (doi: 10.1101/2024.02.23.581333)
Gonzalo Nadal, V. et al. (2024) Suspected tick-borne flavivirus meningoencephalomyelitis in dogs from the UK: six cases (2021). Journal of Small Animal Practice, 65(2), pp. 132-143. (doi: 10.1111/jsap.13682) (PMID:37956993)
Rubina, A. et al. (2023) ADAM17 targeting by human cytomegalovirus remodels the cell surface proteome to simultaneously regulate multiple immune pathways. Proceedings of the National Academy of Sciences of the United States of America, 120(33), e2303155120. (doi: 10.1073/pnas.2303155120) (PMID:37561786) (PMCID:PMC10438378)
Lista, M. J. et al. (2023) Strain-dependent restriction of human cytomegalovirus by zinc finger antiviral proteins. Journal of Virology, 97(3), e0184622. (doi: 10.1128/jvi.01846-22) (PMID:36916924) (PMCID:PMC10062169)
Whitlock, A. O. B. et al. (2023) Identifying the genetic basis of viral spillover using Lassa virus as a test case. Royal Society Open Science, 10(3), 221503. (doi: 10.1098/rsos.221503) (PMID:36968239) (PMCID:PMC10031424)
Vucak, M. et al. (2022) Genome sequences of five arenaviruses from pygmy mice (Mus minutoides) in Sierra Leone. Microbiology Resource Announcements, 11(5), e0009522. (doi: 10.1128/mra.00095-22) (PMID:35389260) (PMCID:PMC9119099)
Aggarwal, D. et al. (2022) Genomic assessment of quarantine measures to prevent SARS-CoV-2 importation and transmission. Nature Communications, 13, 1012. (doi: 10.1038/s41467-022-28371-z) (PMID:35197443) (PMCID:PMC8866425)
Aggarwal, D. et al. (2022) Genomic epidemiology of SARS-CoV-2 in a UK university identifies dynamics of transmission. Nature Communications, 13, 751. (doi: 10.1038/s41467-021-27942-w) (PMID:35136068) (PMCID:PMC8826310)
Nightingale, K. et al. (2022) Human cytomegalovirus protein RL1 degrades the antiviral factor SLFN11 via recruitment of the CRL4 E3 ubiquitin ligase complex. Proceedings of the National Academy of Sciences of the United States of America, 119(6), e2108173119. (doi: 10.1073/pnas.2108173119) (PMID:35105802) (PMCID:PMC8832970)
Twohig, K. A. et al. (2022) Hospital admission and emergency care attendance risk for SARS-CoV-2 delta (B.1.617.2) compared with alpha (B.1.1.7) variants of concern: a cohort study. Lancet Infectious Diseases, 22(1), pp. 35-42. (doi: 10.1016/S1473-3099(21)00475-8) (PMID:34461056) (PMCID:PMC8397301)
Vöhringer, H. S. et al. (2021) Genomic reconstruction of the SARS-CoV-2 epidemic in England. Nature, 600(7889), pp. 506-511. (doi: 10.1038/s41586-021-04069-y) (PMID:34649268) (PMCID:PMC8674138)
Herder, V. et al. (2021) Elevated temperature inhibits SARS-CoV-2 replication in respiratory epithelium independently of IFN-mediated innate immune defences. PLoS Biology, 19(12), e3001065. (doi: 10.1371/journal.pbio.3001065) (PMID:34932557) (PMCID:PMC8765667)
Wood, M. L. et al. (2021) Variation in human herpesvirus 6B telomeric integration, excision and transmission between tissues and individuals. eLife, 10, e70452. (doi: 10.7554/eLife.70452) (PMID:34545807) (PMCID:PMC8492063)
Li, K. K. et al. (2021) Genetic epidemiology of SARS-CoV-2 transmission in renal dialysis units - a high risk community-hospital interface. Journal of Infection, 83(1), pp. 96-103. (doi: 10.1016/j.jinf.2021.04.020) (PMID:33895226) (PMCID:PMC8061788)
Graham, M. S. et al. (2021) Changes in symptomatology, reinfection, and transmissibility associated with the SARS-CoV-2 variant B.1.1.7: an ecological study. Lancet Public Health, 6(5), e335-e345. (doi: 10.1016/S2468-2667(21)00055-4)
Volz, E. et al. (2021) Assessing transmissibility of SARS-CoV-2 lineage B.1.1.7 in England. Nature, 593(7858), pp. 266-269. (doi: 10.1038/s41586-021-03470-x) (PMID:33767447)
Thomson, E. C. et al. (2021) Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity. Cell, 184(5), 1171-1187.e20. (doi: 10.1016/j.cell.2021.01.037) (PMID:33621484) (PMCID:PMC7843029)
Rihn, S. J. et al. (2021) A plasmid DNA-launched SARS-CoV-2 reverse genetics system and coronavirus toolkit for COVID-19 research. PLoS Biology, 19(2), e3001091. (doi: 10.1371/journal.pbio.3001091) (PMID:33630831) (PMCID:PMC7906417)
Al Qaffas, A., Nichols, J. , Davison, A. J. , Ourahmane, A., Hertel, L., McVoy, M. A. and Camiolo, S. (2021) LoReTTA, a user-friendly tool for assembling viral genomes from PacBio sequence data. Virus Evolution, 7(1), veab042. (doi: 10.1093/ve/veab042) (PMID:33996146) (PMCID:PMC8111061)
Da Silva Filipe, A. et al. (2021) Genomic epidemiology reveals multiple introductions of SARS-CoV-2 from mainland Europe into Scotland. Nature Microbiology, 6(1), pp. 112-122. (doi: 10.1038/s41564-020-00838-z) (PMID:33349681)
Parker, M. D. et al. (2021) Subgenomic RNA identification in SARS-CoV-2 genomic sequencing data. Genome Research, 31, pp. 645-658. (doi: 10.1101/gr.268110.120) (PMID:33722935) (PMCID:PMC8015849)
Fletcher-Etherlington, A., Nobre, L., Nightingale, K., Antrobus, R., Nichols, J. , Davison, A. J. , Stanton, R. J. and Weekes, M. P. (2020) Human cytomegalovirus protein pUL36: a dual cell death pathway inhibitor. Proceedings of the National Academy of Sciences of the United States of America, 117(31), pp. 18771-18779. (doi: 10.1073/pnas.2001887117) (PMID:32690704)
Al Qaffas, A., Camiolo, S. , Nichols, J. , Davison, A. J. , Ourahmane, A., Cui, X., Schleiss, M. R., Hertel, L., Dittmer, D. P. and McVoy, M. A. (2020) Genome sequence of human cytomegalovirus Ig-KG-H2, a variant of strain KG propagated in the presence of neutralizing antibodies. Microbiology Resource Announcements, 9(17), e00063-20. (doi: 10.1128/MRA.00063-20) (PMID:32327516) (PMCID:PMC7180270)
Nobre, L. V. et al. (2019) Human cytomegalovirus interactome analysis identifies degradation hubs, domain associations and viral protein functions. eLife, 8, e49894. (doi: 10.7554/elife.49894) (PMID:31873071) (PMCID:PMC6959991)
Protocols
Tong, L., Smollett, K. , Kwok, K. , Nomikou, K. , Galarion, M. J., Mair, D. , Filipe, A. and Nichols, J. (2023) Discovery of RNA and DNA viruses using next-generation sequencing: Metagenomics V.1. [Protocols]
Tong, L., Smollett, K. , Kwok, K. , Nomikou, K. , Galarion, M. J., Mair, D. , Filipe, A. and Nichols, J. (2023) Discovery of RNA and DNA viruses using next-generation sequencing: Targeted enrichment. [Protocols]
Smollett, K. , Tong, L., Nomikou, K. , Nichols, J. , Kwok, K. , Galarion, M. J., Mair, D. and Filipe, A. (2022) Library clean up and quality control for Illumina sequencing. [Protocols]