Selected Publications - Anti-Microbial Resistance
Investigate some of our research into Anti-Mocrobial Resistance and Combating Infection by exploring some of our key publications in this area:
Ahmad, A., Græsbøll, K., Christiansen, L. E., Toft, N., Matthews, L., and Nielsen, S. S. (2015) Pharmacokinetic-pharmacodynamic model to evaluate intramuscular tetracycline treatment protocols to prevent antimicrobial resistance in pigs. Antimicrobial Agents and Chemotherapy, 59(3), pp. 1634-1642. (doi:10.1128/AAC.03919-14)(PMID:25547361)
Beckham, K. S.H., and Roe, A. J. (2014) From screen to target: insights and approaches for the development of anti-virulence compounds. Frontiers in Cellular and Infection Microbiology, 4(139), (doi:10.3389/fcimb.2014.00139)
Benavides JA, Godreuil S, Bodenham R, Ratiarison S, Devos C, Petretto MO, Raymond M, Escobar-Páramo P. No evidence for transmission of antibiotic-resistant Escherichia coli strains from humans to wild western lowland gorillas in Lopé National Park, Gabon. Appl Environ Microbiol. 2012 Jun;78(12):4281-7. doi:10.1128/AEM.07593-11
Brown, C.L., Smith, K., McCaughey, L., and Walker, D. (2012)Colicin-like bacteriocins as novel therapeutic agents for the treatment of chronic biofilm-mediated infection. Biochemical Society Transactions, 40(6), pp. 1549-1552. (doi:10.1042/BST20120241)
Call, D.R., Matthews, L., Subbiah, M., and Liu, J. (2013) Do antibiotic residues in soils play a role in amplification and transmission of antibiotic resistant bacteria in cattle populations? Frontiers in Microbiology, 4(193), pp. 1-8. (doi:10.3389/fmicb.2013.00193)
Carnwath, R., Graham, E.M., Reynolds, K., and Pollock, P.J. (2014) The antimicrobial activity of honey against common equine wound bacterial isolates. Veterinary Journal, 199(1), pp. 110-114. (doi:10.1016/j.tvjl.2013.07.003)
Coia JE, Leanord AT, Reilly J. Screening for meticillin resistant Staphylococcus aureus (MRSA): who, when, and how? BMJ. 2014 Feb 27;348:g1697.
Dryden M, Saeed K, Townsend R, Winnard C, Bourne S, Parker N, Coia J, Jones B, Lawson W, Wade P, Howard P, Marshall S. Antibiotic stewardship and early discharge from hospital: impact of a structured approach to antimicrobial management. J Antimicrob Chemother. 2012 Sep;67(9):2289-96
Everest, P., Hamilton, K., and Coia , J. (2010) The use of culture based screening as a semi-quantitative predictor of hospital MRSA acquisition. Journal of Hospital Infection, 76(Sup. 1), S7. (doi:10.1016/S0195-6701(10)60023-0)
Gabrielsen, M., Beckham, K. S. H., Feher, V. A., Zetterström, C. E., Wang, D., Müller, S., Elofsson, M., Amaro, R., Byron, O. and Roe, A. J. Structural characterisation of Tpx from Yersinia pseudotuberculosis reveals insights into the binding of salicylidene acylhydrazide compounds. PLoS ONE, 2012, 7, e32217 (doi:10.1371/journal.pone.0032217).
Grinter, R., Josts, I., Zeth, K., Roszak A. W., McCaughey L., Cogdell, R. J., Milner, J. J., Kelly, S., Smith, B., Byron, O. and Walker D. (2014) The structure of pectocin M2 suggests an alternative translocation pathway for colicin-like bacteriocins and protein uptake for nutrient acquisition in Gram-negative bacteria. Molecular Microbiology, 93, 234-46 (doi: 10.1111/mmi.12655).
Grinter, R., Milner, J., and Walker, D. (2013) Beware of proteins bearing gifts: protein antibiotics that use iron as a Trojan horse. FEMS Microbiology Letters, 338(1), pp. 1-9. (doi:10.1111/1574-6968.12011)
Harrison EM, Paterson GK, Holden MT, Larsen J, Stegger M, Larsen AR, Petersen A, Skov RL, Christensen JM, Bak Zeuthen A, Heltberg O, Harris SR, Zadoks RN, Parkhill J, Peacock SJ, Holmes MA. Whole genome sequencing identifies zoonotic transmission of MRSA isolates with the novel mecA homologue mecC. EMBO Mol Med. 2013 Apr;5(4):509-15. doi: 10.1002/emmm.201202413. Epub 2013 Mar 25. PubMed PMID: 23526809; PubMed Central PMCID: PMC3628104.
Heller, J., Innocent, G.T., Denwood, M.J., Reid, S.W.J., Kelly, L., and Mellor, D.J. (2011) Assessing the probability of acquisition of meticillin-resistant Staphylococcus aureus (MRSA) in a dog using a nested stochastic simulation model and logistic regression sensitivity analysis. Preventive Veterinary Medicine, 99(2-4), pp. 211-224. (doi:10.1016/j.prevetmed.2010.10.007)
Leuzzi, R., Spencer, J., Buckley, A., Brettoni, C., Martinelli, M., Tulli, L., Marchi, S.,Luzzi, E., Irvine, J., Candlish, D., Veggi, D., Pansegrau, W., Fiaschi, L., Savino, S., Swennen, E., Cakici, O., Oviedo-Orta E, Giraldi M, Baudner B, D'Urzo N, Maione D, Soriani M, Rappuoli, R., Pizza, M., Douce, G.R., Scarselli, M. (2013) Protective efficacy induced by recombinant Clostridium difficile toxin fragments. Infect Immun 81:2851-60.
Mather, A.E. et al. (2013) Distinguishable epidemics of multidrug-resistant Salmonella typhimurium DT104 in different hosts. Science, 341(6153), pp. 1514-1517. (doi:10.1126/science.1240578)
Mather AE, Matthews L, Mellor DJ, Reeve R, Denwood MJ, Boerlin P, Reid-Smith RJ, Brown DJ, Coia JE, Browning LM, Haydon DT, Reid SW. (2012) An ecological approach to assessing the epidemiology of antimicrobial resistance in animal and human populations. Proceedings of the Royal Society of London Series B: Biological Sciences, 279(1733), pp. 1630-1639. (doi:10.1098/rspb.2011.1975) .
Mather, A.E. et al. (2012) The diversity of antimicrobial resistance is different in Salmonella Typhimurium DT104 from co-located animals and humans. Proceedings of the Royal Society of London Series B: Biological Sciences, 279(1740), pp. 2924-2925.(doi:10.1098/rspb.2012.0614)
Paterson, G.K., Morgan, F.J.E., Harrison, E.M., Cartwright, E.J.P., Torok, M.E., Zadoks, R.N., Parkhill, J., Peacock, S.J., and Holmes, M.A. (2014) Prevalence and characterization of human mecC methicillin-resistant Staphylococcus aureus isolates in England. Journal of Antimicrobial Chemotherapy, 69(4), pp. 907-910. (doi:10.1093/jac/dkt462)
Paterson, G.K., Morgan, F.J.E., Harrison, E.M., Peacock, S.J., Parkhill, J., Zadoks, R.N., and Holmes, M.A. (2014) Prevalence and properties of mecC methicillin-resistant Staphylococcus aureus (MRSA) in bovine bulk tank milk in Great Britain. Journal of Antimicrobial Chemotherapy, 69(3), pp. 598-602. (doi:10.1093/jac/dkt417)
Spencer, J., Leuzzi, R., Buckley, A.M., Irvine, J.J., Candlish, D., Scarselli, M., Douce, G.R. (2014). Vaccination against Clostridium difficile using toxin fragments: Observations and analysis in animal models. Gut Microbes. 5:225-32.
Strachan, N.J.C. et al. (2013) Identifying the seasonal origins of human campylobacteriosis. Epidemiology and Infection, 141(06), pp. 1267-1275. (doi:10.1017/S0950268812002063)
Walker, D. (2015) Activity of species-specific antibiotics against Crohn’s disease associated adherent-invasive E. coli. Inflammatory Bowel Diseases, (Accepted for Publication)
Wiuff C, Murdoch H, Coia JE. Control of Clostridium difficile infection in the hospital setting. Expert Rev Anti Infect Ther. 2014 Apr;12(4):457-69.
Zambelloni, R., Marquez, R., and Roe, A. J. (2015) Development of antivirulence compounds: a biochemical review. Chemical Biology and Drug Design, 85(1), pp. 43-55. (doi:10.1111/cbdd.12430)