Professor Sheila Graham

Professor of Molecular Virology (Centre for Virus Research)
Associate (Institute of Cancer Sciences)
Associate (School of Life Sciences)

telephone: 01413306256
email: Sheila.Graham@glasgow.ac.uk

Centre for Virus Research, 464 Bearsden Road, Garscube Estate G61 1QH

ORCID iD https://orcid.org/0000-0002-7140-8279

Research interests

My group investigates the links between human papillomavirus (HPV) infectious lifecyle & epithelial differentiation, and how HPV-associated tumour progression is achieved. Our studies range from basic molecular & cellular virology to clinical studies in HPV testing & therapeutics.

Publications

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Number of items: 58.

2021

Herder, V. et al. (2021) Elevated temperature inhibits SARS-CoV-2 replication in respiratory epithelium independently of IFN-mediated innate immune defences. PLoS Biology, 19(12), e3001065. (doi: 10.1371/journal.pbio.3001065) (PMID:34932557)

Cuschieri, K., Pan, J., O Donnell, M., Kirkwood, K., Kavanagh, K., Pollock, K.G., Bhatia, R., Graham, S.V. and Wakeham, K. (2021) Penile cancer and the HPV attributable fraction in Scotland; a retrospective cohort study. Journal of Clinical Virology, 134, 104717. (doi: 10.1016/j.jcv.2020.104717) (PMID:33360857)

2020

Graham, S. , Mole, S., Faizo, A. A. A., Hernandez-Lopez, H., Griffiths, M., Stevenson, A. and Roberts, S. (2020) Human papillomavirus type 16 infection activates the host serine arginine protein kinase 1 (SRPK1) - splicing factor axis. Journal of General Virology, 101(5), pp. 523-532. (doi: 10.1099/jgv.0.001402) (PMID:32182205)

2019

Wakeham, K. et al. (2019) A prospective cohort study of human papillomavirus-driven oropharyngeal cancers: implications for prognosis and immunisation. Clinical Oncology, 31(9), e132-e142. (doi: 10.1016/j.clon.2019.05.010) (PMID:31248692)

Pan, J. et al. (2019) Increased risk of HPV-associated genital cancers in men and women as a consequence of pre-invasive disease. International Journal of Cancer, 145(2), pp. 427-434. (doi: 10.1002/ijc.32126) (PMID:30650180)

Aasen, T., Leithe, E., Graham, S. V. , Kameritsch, P., Mayán, M. D., Mesnil, M., Pogoda, K. and Tabernero, A. (2019) Connexins in cancer: bridging the gap to the clinic. Oncogene, 38(23), pp. 4429-4451. (doi: 10.1038/s41388-019-0741-6) (PMID:30814684) (PMCID:PMC6555763)

Saiz-Ros, N. et al. (2019) Host vesicle fusion protein VAPB contributes to the nuclear egress stage of herpes simplex virus type-1 (HSV-1) replication. Cells, 8(2), 120. (doi: 10.3390/cells8020120)

2018

Stevenson, A., Kavanagh, K., Pan, J., Stevenson, L., Griffin, H., Doorbar, J., Scott, E., Deeny, M., Cuschieri, K. and Graham, S. V. (2018) Risk stratification of cervical disease using detection of human papillomavirus (HPV) E4 protein and cellular MCM protein in clinical liquid based cytology samples. Journal of Clinical Virology, 108, pp. 19-25. (doi: 10.1016/j.jcv.2018.08.011) (PMID:30218891) (PMCID:PMC6224362)

Graham, S. V. , Jiang, J. X. and Mesnil, M. (2018) Connexins and pannexins: important players in tumorigenesis, metastasis and potential therapeutics. International Journal of Molecular Sciences, 19(6), 1645. (doi: 10.3390/ijms19061645) (PMID:29865195)

2017

Klymenko, T. et al. (2017) RNA-Seq analysis of differentiated keratinocytes reveals a massive response to late events during human papillomavirus 16 infection, including loss of epithelial barrier function. Journal of Virology, 91(24), e01001-17. (doi: 10.1128/JVI.01001-17) (PMID:29021401) (PMCID:PMC5709591)

Graham, S. V. (2017) The human papillomavirus replication cycle, and its links to cancer progression: a comprehensive review. Clinical Science, 131(17), pp. 2201-2221. (doi: 10.1042/CS20160786) (PMID:28798073)

Graham, S. V. (2017) Keratinocyte differentiation-dependent human papillomavirus gene regulation. Viruses, 9(9), 245. (doi: 10.3390/v9090245) (PMID:28867768) (PMCID:PMC5618011)

Smith, R. W.P., Anderson, R. C., Larralde, O., Smith, J. W.S., Gorgoni, B., Richardson, W. A., Malik, P., Graham, S. V. and Gray, N. K. (2017) Viral and cellular mRNA-specific activators harness PABP and eIF4G to promote translation initiation downstream of cap binding. Proceedings of the National Academy of Sciences of the United States of America, 114(24), pp. 6310-6315. (doi: 10.1073/pnas.1610417114) (PMID:28559344) (PMCID:PMC5474791)

Graham, S. and Faizo, A. A. A. (2017) Control of human papillomavirus gene expression by alternative splicing. Virus Research, 231, pp. 83-95. (doi: 10.1016/j.virusres.2016.11.016) (PMID:27867028) (PMCID:PMC5335905)

Wakeham, K., Kavanagh, K., Cuschieri, K., Millan, D., Pollock, K. G., Bell, S., Burton, K., Reed, N. S. and Graham, S. V. (2017) HPV status and favorable outcome in vulvar squamous cancer. International Journal of Cancer, 140(5), pp. 1134-1146. (doi: 10.1002/ijc.30523) (PMID:27864932)

2016

Graham, S. V. (2016) Human papillomavirus E2 protein: linking replication, transcription, and RNA processing. Journal of Virology, 90(19), pp. 8384-8388. (doi: 10.1128/JVI.00502-16) (PMID:27412596)

Klymenko, T., Hernandez-Lopez, H., MacDonald, A.I., Bodily, J. M. and Graham, S. V. (2016) Human papillomavirus E2 regulates SRSF3 (SRp20) to promote capsid protein expression in infected differentiated keratinocytes. Journal of Virology, 90(10), pp. 5047-5058. (doi: 10.1128/JVI.03073-15) (PMID:26962216)

2015

Sun, P., Dong, L., MacDonald, A. I., Akbari, S., Edward, M., Hodgins, M. B., Johnstone, S. R. and Graham, S. V. (2015) HPV16 E6 controls the gap junction protein Cx43 in cervical tumour cells. Viruses, 7(10), pp. 5243-5256. (doi: 10.3390/v7102871) (PMID:26445057) (PMCID:PMC4632379)

McFarlane, M. , MacDonald, A. I., Stevenson, A. and Graham, S. V. (2015) Human papillomavirus type 16 oncoprotein expression is controlled by the cellular splicing factor SRSF2 (SC35). Journal of Virology, 89(10), pp. 5276-5287. (doi: 10.1128/JVI.03434-14) (PMID:25717103)

2014

Prescott, E. L., Brimacombe, C. L., Hartley, M., Bell, I., Graham, S. and Roberts, S. (2014) Human papillomavirus type 1 E1^E4 protein is a potent inhibitor of the Serine-Arginine (SR) protein kinase SRPK1 and inhibits phosphorylation of host SR proteins and of the viral transcription and replication regulator E2. Journal of Virology, 88(21), pp. 12599-12611. (doi: 10.1128/JVI.02029-14)

Chambers, G., Millan, D., Cuschieri, K., Cubie, H.A. and Graham, S.V. (2014) Assessing the detection of human papillomavirus late mRNA in liquid base cytology samples for risk stratification of cervical disease. Journal of Medical Virology, 86(4), pp. 627-633. (doi: 10.1002/jmv.23793) (PMID:24142394) (PMCID:PMC4282440)

2013

Braidwood, L., Graham, S.V. , Graham, A. and Conner, J. (2013) Oncolytic herpes viruses, chemotherapeutics, and other cancer drugs. Oncolytic Virotherapy, 2, pp. 57-74. (doi: 10.2147/OV.S52601)

McCusker, S.M., Macqueen, I., Lough, G., MacDonald, A.I., Campbell, C. and Graham, S.V. (2013) Gaps in detailed knowledge of human papillomavirus (HPV) and the HPV vaccine among medical students in Scotland. BMC Public Health, 13(264), (doi: 10.1186/1471-2458-13-264)

2012

Malik, P., Tabarraei, A., Kehlenbach, R. H., Korfali, N., Iwasawa, R., Graham, S. and Schirmer, E. C. (2012) Herpes simplex virus ICP27 protein directly interacts with the nuclear pore complex through NUP62, inhibiting host nucleocytoplasmic transport pathways. Journal of Biological Chemistry, 287(15), pp. 12277-12292. (doi: 10.1074/jbc.M111.331777)

Hernandez-Lopez, H. and Graham, S. (2012) Alternative splicing in tumour viruses: a therapeutic target? Biochemical Journal, 445, pp. 145-156. (doi: 10.1042/BJ20120413) (PMID:22738337)

Hernandez-Lopez, H.R. and Graham, S.V. (2012) Alternative splicing in human tumour viruses: a therapeutic target? Biochemical Journal, 445(2), pp. 145-156.

Klymenko, T. and Graham, S. (2012) Human papillomavirus gene expression is controlled by host cell splicing factors. Biochemical Society Transactions, 40, pp. 773-777. (doi: 10.1042/BST20120079) (PMID:22817732)

MacDonald, A.I. et al. (2012) A functional interaction between the MAGUK protein hDlg and the gap junction protein Connexin 43 in cervical tumour cells. Biochemical Journal, 446(1), pp. 9-21. (doi: 10.1042/BJ20111144)

2011

Burgess, H. M., Richardson, W. A., Anderson, R. C., Salaun, C., Graham, S. V. and Gray, N. K. (2011) Nuclear relocalisation of cytoplasmic poly(A)-binding proteins PABP1 and PABP4 in response to UV irradiation reveals mRNA-dependent export of metazoan PABPs. Journal of Cell Science, 124(19), pp. 3344-3355. (doi: 10.1242/jcs.087692)

2010

Salaun, C., MacDonald, A.I., Larralde, O., Howard, L., Lochtie, K., Burgess, H.M., Brook, M., Malik, P., Gray, N.K. and Graham, S.V. (2010) Poly(A)-binding protein 1 (PABP1) partially relocalises to the nucleus during HSV-1 infection in an ICP27-independent manner and does not inhibit virus replication. Journal of Virology, 84(17), pp. 8539-8548. (doi: 10.1128/JVI.00668-10) (PMID:20573819) (PMCID:PMC2919032)

Salaun, C., MacDonald, A.I., Larralde, O., Howard, L., Lochtie, K., Burgess, H.M., Brook, M., Malik, P., Gray, N.K. and Graham, S.V. (2010) Poly(A)-binding protein 1 partially relocalizes to the nucleus during herpes simplex virus type 1 infection in an ICP27-independent manner and does not inhibit virus replication. Journal of Virology, 84(17), pp. 8539-8548. (doi: 10.1128/JVI.00668-10)

Chuen-Im, T., Areekijseree, M., Chongthammakun, S. and Graham, S.V. (2010) Aerobic bacterial infections in captive juvenile green turtles (Chelonia mydas) and hawksbill turtles (Eretmochelys imbricata) from Thailand. Chelonian Conservation and Biology, 9(1), pp. 135-142. (doi: 10.2744/CCB-0808.1)

Barbaresi, S., Cortese, M. S., Quinn, J., Ashrafi, G. H., Graham, S.V. and Campo, M.S. (2010) Effects of human papillomavirus type 16 E5 deletion mutants on epithelial morphology: functional characterization of each transmembrane domain. Journal of General Virology, 91(2), pp. 521-530. (doi: 10.1099/vir.0.016295-0)

Campo, M.S., Graham, S.V. , Cortese, M.S., Ashrafi, G.H., Araibi, E.H., Dornan, E.S., Miners, K., Nunes, C. and Man, S. (2010) HPV-16 E5 down-regulates expression of surface HLA class I and reduces recognition by CD8 T cells. Virology, 407(1), pp. 137-142. (doi: 10.1016/j.virol.2010.07.044)

Chuen-Im, T., Areekijseree, M., Chongthammakun, S. and Graham, S.V. (2010) Aerobic Bacterial Infections in Captive Juvenile Green Turtles (Chelonia mydas) and Hawksbill Turtles (Eretmochelys imbricata) from Thailand. Chelonian Conservation and Biology, 9(1), pp. 135-142. (doi: 10.2744/CCB-0808.1)

Graham, S.V. (2010) Human papillomavirus: gene expression, regulation and prospects for novel diagnostic methods and antiviral therapies. Future Microbiology, 5(10), pp. 1493-1506. (doi: 10.2217/fmb.10.107)

McFarlane, M. and Graham, S.V. (2010) Human papillomavirus regulation of SR proteins. Biochemical Society Transactions, 38(4), pp. 1116-1121. (doi: 10.1042/BST0381116)

2009

Johansson, C., Graham, S.V. , Dornan, E.S. and Morgan, I.M. (2009) The human papillomavirus 16 E2 protein is stabilised in S phase. Virology, 394(2), pp. 194-199. (doi: 10.1016/j.virol.2009.08.046) (PMID:19781729)

Mole, S., McFarlane, M. , Chuen-Im, T., Milligan, S.G., Millan, D. and Graham, S.V. (2009) RNA splicing factors regulated by HPV16 during cervical tumour progression. Journal of Pathology, 219(3), pp. 383-391. (doi: 10.1002/path.2608) (PMID:19718710) (PMCID:PMC2779514)

Cumming, S.A., Chuen-Im, T., Zhang, J. and Graham, S.V. (2009) The RNA stability regulator HuR regulates L1 protein expression in vivo in differentiating cervical epithelial cells. Virology, 383(1), pp. 142-149. (doi: 10.1016/j.virol.2008.10.003)

Mole, S., Milligan, S.G. and Graham, S.V. (2009) Human Papillomavirus Type 16 E2 Protein Transcriptionally Activates the Promoter of a Key Cellular Splicing Factor, SF2/ASF. Journal of Virology, 83(1), pp. 357-367. (doi: 10.1128/JVI.01414-08) (PMID:18945764) (PMCID:PMC2612322)

2008

Smith, R. W.P., Graham, S. V. and Gray, N. K. (2008) Regulation of translation initiation by herpesviruses. Biochemical Society Transactions, 36(4), pp. 701-707. (doi: 10.1042/BST0360701)

Cheunim, T., Zhang, J., Milligan, S.G., McPhillips, M.G. and Graham, S.V. (2008) The alternative splicing factor hnRNP A1 is up-regulated during virus-infected epithelial cell differentiation and binds the human papillomavirus type 16 late regulatory element. Virus Research, 131(2), pp. 189-198. (doi: 10.1016/j.virusres.2007.09.006)

Cumming, S. A., Cheun-Im, T., Milligan, S. G. and Graham, S. V. (2008) Human papillomavirus type 16 late gene expression is regulated by cellular RNA processing factors in response to epithelial differentiation. Biochemical Society Transactions, 36(3), pp. 522-524. (doi: 10.1042/BST0360522)

Graham, S.V. (2008) Papillomavirus 3' UTR regulatory elements. Frontiers in Bioscience, 13(1), pp. 5646-5663. (doi: 10.2741/3107)

2007

Milligan, S., Veerapraditsin, T., Ahamet, B., Mole, S. and Graham, S. (2007) Analysis of novel human papillomavirus type 16 late mRNAs in differentiated W12 cervical epithelial cells. Virology, 360, pp. 172-181. (doi: 10.1016/j.virol.2006.10.012)

2006

Mole, S., Veerapraditsin, T., McPhillips, M. and Graham, S. (2006) Regulation of splicing-associated SR proteins by HPV-16. Biochemical Society Transactions, 34, pp. 1145-1147.

2005

Aasen, T., Edward, M., Graham, S. and Hodgins, M. (2005) Reduced expression of multiple gap junction proteins is a feature of cervical dysplasia. Molecular Cancer, 4, (doi: 10.1186/1476-4598-4-31)

Daly, N.L., Arvanitis, D.A., Fairley, J.A., Gomez-Roman, N. , Morton, J.P. , Graham, S.V., Spandidos, D.A. and White, R.J. (2005) Deregulation of RNA polymerase III transcription in cervical epithelium in response to high-risk human papillomavirus. Oncogene, 24, pp. 880-888. (doi: 10.1038/sj.onc.1208031)

Graham, S. (2005) Analysis of regulatory motifs within HPV transcripts. Methods in Molecular Medicine, 119(.), pp. 291-315.

2004

McPhillips, M. G., Veerapraditsin, T., Cumming, S. A., Karali, D., Milligan, S. G., Boner, W. , Morgan, I. M. and Graham, S. V. (2004) SF2/ASF binds the human papillomavirus type 16 late RNA control element and is regulated during differentiation of virus-infected epithelial cells. Journal of Virology, 78, pp. 10598-10605. (doi: 10.1128/JVI.78.19.10598-10605.2004) (PMID:15367627) (PMCID:PMC516382)

2003

Aasen, T., Edward, M., Graham, S. and Hodgins, M. (2003) The relationship between connexins, gap junctions, tissue architecture and tumour invasion, as studied in a novel in vitro model of HPV-16-associated cervical cancer progression. Oncogene, 22, pp. 7969-7980. (doi: 10.1038/sj.onc.1206709)

Cumming, S., McPhillips, M., Veerapraditsin, T., Milligan, S. and Graham, S. (2003) Activity of the human papillomavirus type 16 late negative regulatory element is partly due to four weak consensus 5 ' splice sites that bind a U1 snRNP-like complex. Journal of Virology, 77, pp. 5167-5177. (doi: 10.1128/JVI.77.9.5167-5177.2003)

Graham, S. (2003) Nonsense-mediated decay breaks the circle? Biochemical Journal, 373(Pt 3), e5-e6.

2002

Attrill, H., Cumming, S., Clements, J. and Graham, S. (2002) The herpes simplex virus type 1 US11 protein binds the coterminal UL12, UL13, and UL14 RNAs and regulates UL13 expression in vivo. Journal of Virology, 76, pp. 8090-8100. (doi: 10.1128/JVI.76.16.8090-8100.2002)

Cumming, S., Repellin, C., McPhillips, M., Radford, J., Clements, J. and Graham, S. (2002) The human papillomavirus type 31 late 3 ' untranslated region contains a complex bipartite negative regulatory element. Journal of Virology, 76, pp. 5993-6003. (doi: 10.1128/JVI.76.12.5993-6003.2002)

2001

Adamson, R., Lyons, K., Sharrard, M., Kinnaird, J., Swan, D., Graham, S. , Shiels, B. and Hall, R. (2001) Transient transfection of Theileria annulata. Molecular and Biochemical Parasitology, 114, pp. 53-61. (PMID:11356513)

This list was generated on Mon Jan 24 16:45:53 2022 GMT.

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