Dr Sam Wilson

  • Senior Research Fellow (Centre for Virus Research)

telephone: 0141 330 4557
email: Sam.Wilson@glasgow.ac.uk

Research interests

CVR logo

The ‘antiviral state’ induced by interferons attenuates the replication of most, if not all, mammalian viruses. Upon sensing a pathogen, interferon signaling results in the upregulation of hundreds of different genes. These interferon stimulated genes (ISGs) are able to mediate further signaling, modulate the cellular environment, or interfere with viruses directly, in order to impede viral replication. Despite intensive investigation, the exact contribution of individual ISGs to the antiviral state is often unknown. However, in some remarkable cases individual ISGs have been described that effectively render cells resistant to certain viruses. The extraordinary ability of these factors to restrict virus replication can protect individuals, populations and entire species from specific pathogens.

It is my belief that many restriction factors remain unidentified because evolution has rendered viruses supremely adept at avoiding and disabling the arsenal of intrinsic immune effectors within the host cell. My lab is focused on identifying and characterising these novel intrinsic immune factors. We mainly investigate a diverse range of retroviruses where multiple antiretroviral ISGs, such as APOBEC3G, TRIM5, tetherin and SAMHD1 have redefined our understanding of species-specific restriction. Based on this experience we utilize both human and rhesus macaque ISG-expression libraries to investigate retroviral replication. We are also diversifying our approach and applying medium- throughput ISG expression screening to an expanding array of virus families.

Our long-term goal is to harness the information gleaned from characterising host-viral interactions to identify novel therapeutic targets and develop biotechnologies, based upon intrinsic immune factors, that could reduce the disease burden in human or livestock populations.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Quinquennial Core Funds
    Medical Research Council
    2016 - 2021
     
  • Comparing the fitness and patient landscapes of HIV-1 (ISSF Catalyst)
    Wellcome Trust
    2014 - 2015
     
  • Identifying and characterising antiretroviral interferon stimulated genes (ISGs)
    Medical Research Council
    2013 - 2018
     

Publications

List by: Type | Date

Jump to: 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005
Number of items: 24.

2017

Rihn, S. J., Foster, T. L., Busnadiego, I., Aziz, M. A., Hughes, J., Neil, S. J.D. and Wilson, S. J. (2017) The envelope gene of transmitted HIV-1 resists a late interferon gamma-induced block. Journal of Virology, 91(7), e02254-16. (doi:10.1128/JVI.02254-16) (PMID:28100611) (PMCID:PMC5355616)

Terry, A., Kilbey, A., Naseer, A., Levy, L. S., Ahmad, S., Watts, C., Mackay, N., Cameron, E., Wilson, S. and Neil, J. C. (2017) Barriers to infection of human cells by feline leukemia virus: insights into resistance to zoonosis. Journal of Virology, 91(5), e02119-16. (doi:10.1128/JVI.02119-16) (PMID:28031367) (PMCID:PMC5309941)

2016

Kane, M., Zang, T. M., Rihn, S. J., Zhang, F., Kueck, T., Alim, M., Schoggins, J., Rice, C. M., Wilson, S. J. and Bieniasz, P. D. (2016) Identification of interferon-stimulated genes with antiretroviral activity. Cell Host and Microbe, 20(3), pp. 392-405. (doi:10.1016/j.chom.2016.08.005) (PMID:27631702) (PMCID:PMC5026698)

2015

Rihn, S. J., Hughes, J., Wilson, S. J. and Bieniasz, P. D. (2015) Uneven genetic robustness of HIV-1 integrase. Journal of Virology, 89(1), pp. 552-567. (doi:10.1128/JVI.02451-14)

Dittmann, M. et al. (2015) A Serpin shapes the extracellular environment to prevent influenza A virus maturation. Cell, 160(4), pp. 631-643. (doi:10.1016/j.cell.2015.01.040) (PMID:25679759)

2014

Busnadiego, I. et al. (2014) Host and viral determinants of Mx2 antiretroviral activity. Journal of Virology, 88(14), pp. 7738-7752. (doi:10.1128/JVI.00214-14) (PMID:24760893) (PMCID:PMC4097781)

2013

Kane, M. et al. (2013) MX2 is an interferon-induced inhibitor of HIV-1 infection. Nature, 502(7472), pp. 563-566. (doi:10.1038/nature12653)

Rihn, S.J., Wilson, S.J., Loman, N.J., Alim, M., Bakker, S.E., Bhella, D., Gifford, R.J., Rixon, F.J. and Bieniasz, P.D. (2013) Extreme genetic fragility of the HIV-1 capsid. PLoS Pathogens, 9(6), e1003461. (doi:10.1371/journal.ppat.1003461) (PMID:23818857) (PMCID:PMC3688543)

Soll, S.J., Wilson, S.J., Kutluay, S.B., Hatziioannou, T. and Bieniasz, P.D. (2013) Assisted evolution enables hiv-1 to overcome a high trim5α-imposed genetic barrier to rhesus macaque tropism. PLoS Pathogens, 9(9), e1003667. (doi:10.1371/journal.ppat.1003667)

2012

Wilson, S.J., Schoggins, J.W., Zang, T., Kutluay, S.B., Jouvenet, N., Alim, M., Bitzegeio, J., Rice, C.M. and Bieniasz, P.D. (2012) Inhibition of HIV-1 Particle Assembly by 2′,3′-Cyclic-Nucleotide 3′-Phosphodiesterase. Cell Host and Microbe, 12(4), pp. 585-597. (doi:10.1016/j.chom.2012.08.012)

Wilson, S.J., Schoggins, J.W., Zang, T., Kutluay, S.B., Jouvenet, N., Alim, M.A., Bitzegeio, J., Rice, C.M. and Bieniasz, P.D. (2012) Inhibition of HIV-1 particle assembly by 2′,3′-cyclic-nucleotide 3′-phosphodiesterase. Cell Host and Microbe, 12(4), pp. 585-597. (doi:10.1016/j.chom.2012.08.012)

Yadav, S.S., Wilson, S.J. and Bieniasz, P.D. (2012) A facile quantitative assay for viral particle genesis reveals cooperativity in virion assembly and saturation of an antiviral protein. Virology, 429(2), pp. 155-162. (doi:10.1016/j.virol.2012.04.008)

2011

Zhang, F., Zang, T., Wilson, S.J., Johnson, M.C. and Bieniasz, P.D. (2011) Clathrin facilitates the morphogenesis of retrovirus particles. PLoS Pathogens, 7(6), e1002119. (doi:10.1371/journal.ppat.1002119)

2010

Pardieu, C., Vigan, R., Wilson, S.J., Calvi, A., Zang, T., Bieniasz, P., Kellam, P., Towers, G.J. and Neil, S.J.D. (2010) The RING-CH ligase K5 antagonizes restriction of KSHV and HIV-1 particle release by mediating ubiquitin-dependent endosomal degradation of tetherin. PLoS Pathogens, 6(4), e1000843. (doi:10.1371/journal.ppat.1000843)

Schoggins, J.W., Wilson, S.J., Panis, M., Murphy, M., Jones, C.T., Bieniasz, P.D. and Rice, C.M. (2010) A diverse range of gene products are effectors of the type I interferon antiviral response. Nature, 472(7344), pp. 481-485. (doi:10.1038/nature09907)

2009

Price, A. J., Marzetta, F., Lammers, M., Ylinen, L.M.J., Schaller, T., Wilson, S.J., Towers, G.J. and James, L.C. (2009) Active site remodeling switches HIV specificity of antiretroviral TRIMCyp. Nature Structural and Molecular Biology, 16(10), pp. 1036-42. (doi:10.1038/nsmb.1667)

Dalton-Griffin, L., Wilson, S.J. and Kellam, P. (2009) X-box binding protein 1 contributes to induction of the Kaposi's sarcoma-associated herpesvirus lytic cycle under hypoxic conditions. Journal of Virology, 83(14), pp. 7202-7209. (doi:10.1128/JVI.00076-09)

Zaitseva, L., Cherepanov, P., Leyens, L., Wilson, S.J., Rasaiyaah, J. and Fassati, A. (2009) HIV-1 exploits importin 7 to maximize nuclear import of its DNA genome. Retrovirology, 6(11), (doi:10.1186/1742-4690-6-11)

Zhang, F., Wilson, S.J., Landford, W.C., Virgen, B., Gregory, D., Johnson, M.C., Munch, J., Kirchoff, F., Bieniasz, P.D. and Hatziioannou, T. (2009) Nef proteins from simian immunodeficiency viruses are tetherin antagonists. Cell Host and Microbe, 6(1), pp. 54-67. (doi:10.1016/j.chom.2009.05.008)

2008

Wilson, S.J., Webb, B.L.J., Maplanka, C., Newman, R.M., Verschoor, E.J., Heeney, J.L. and Towers, G.J. (2008) Rhesus macaque TRIM5 alleles have divergent antiretroviral specificities. Journal of Virology, 82(14), pp. 7243-7247. (doi:10.1128/JVI.00307-08)

Wilson, S.J., Webb, B.L.J., Ylinen, L.M., Verschoor, E., Heeney, J.L. and Towers, G.J. (2008) Independent evolution of an antiviral TRIMCyp in rhesus macaques. Proceedings of the National Academy of Sciences of the United States of America, 105(9), 3557 -3562. (doi:10.1073/pnas.0709003105)

2007

Wilson, S.J., Tsao, E.H., Webb, B.L.J., Ye, H., Dalton-Griffin, L., Tsantoulas, C., Gale, C.V., Du, M.-Q., Whitehouse, A. and Kellam, P. (2007) X box binding protein XBP-1s transactivates the Kaposi's sarcoma-associated herpesvirus (KSHV) ORF50 promoter, linking plasma cell differentiation to KSHV reactivation from latency. Journal of Virology, 81(24), pp. 13578-13586. (doi:10.1128/JVI.01663-07)

2006

Clements, M.O., Godfrey, A., Crossley, J., Wilson, S.J., Takeuchi, Y. and Boshoff, C. (2006) Lentiviral manipulation of gene expression in human adult and embryonic stem cells. Tissue Engineering, 12(7), pp. 1741-1751. (doi:10.1089/ten.2006.12.1741)

2005

Ylinen, L.M.J., Keckesova, Z., Wilson, S.J., Ranasinghe, S. and Towers, G.J. (2005) Differential restriction of human immunodeficiency virus type 2 and simian immunodeficiency virus SIVmac by TRIM5alpha alleles. Journal of Virology, 79(18), pp. 11580-11587. (doi:10.1128/JVI.79.18.11580-11587.2005)

This list was generated on Fri Oct 20 07:53:27 2017 BST.
Jump to: Articles
Number of items: 24.

Articles

Rihn, S. J., Foster, T. L., Busnadiego, I., Aziz, M. A., Hughes, J., Neil, S. J.D. and Wilson, S. J. (2017) The envelope gene of transmitted HIV-1 resists a late interferon gamma-induced block. Journal of Virology, 91(7), e02254-16. (doi:10.1128/JVI.02254-16) (PMID:28100611) (PMCID:PMC5355616)

Terry, A., Kilbey, A., Naseer, A., Levy, L. S., Ahmad, S., Watts, C., Mackay, N., Cameron, E., Wilson, S. and Neil, J. C. (2017) Barriers to infection of human cells by feline leukemia virus: insights into resistance to zoonosis. Journal of Virology, 91(5), e02119-16. (doi:10.1128/JVI.02119-16) (PMID:28031367) (PMCID:PMC5309941)

Kane, M., Zang, T. M., Rihn, S. J., Zhang, F., Kueck, T., Alim, M., Schoggins, J., Rice, C. M., Wilson, S. J. and Bieniasz, P. D. (2016) Identification of interferon-stimulated genes with antiretroviral activity. Cell Host and Microbe, 20(3), pp. 392-405. (doi:10.1016/j.chom.2016.08.005) (PMID:27631702) (PMCID:PMC5026698)

Rihn, S. J., Hughes, J., Wilson, S. J. and Bieniasz, P. D. (2015) Uneven genetic robustness of HIV-1 integrase. Journal of Virology, 89(1), pp. 552-567. (doi:10.1128/JVI.02451-14)

Dittmann, M. et al. (2015) A Serpin shapes the extracellular environment to prevent influenza A virus maturation. Cell, 160(4), pp. 631-643. (doi:10.1016/j.cell.2015.01.040) (PMID:25679759)

Busnadiego, I. et al. (2014) Host and viral determinants of Mx2 antiretroviral activity. Journal of Virology, 88(14), pp. 7738-7752. (doi:10.1128/JVI.00214-14) (PMID:24760893) (PMCID:PMC4097781)

Kane, M. et al. (2013) MX2 is an interferon-induced inhibitor of HIV-1 infection. Nature, 502(7472), pp. 563-566. (doi:10.1038/nature12653)

Rihn, S.J., Wilson, S.J., Loman, N.J., Alim, M., Bakker, S.E., Bhella, D., Gifford, R.J., Rixon, F.J. and Bieniasz, P.D. (2013) Extreme genetic fragility of the HIV-1 capsid. PLoS Pathogens, 9(6), e1003461. (doi:10.1371/journal.ppat.1003461) (PMID:23818857) (PMCID:PMC3688543)

Soll, S.J., Wilson, S.J., Kutluay, S.B., Hatziioannou, T. and Bieniasz, P.D. (2013) Assisted evolution enables hiv-1 to overcome a high trim5α-imposed genetic barrier to rhesus macaque tropism. PLoS Pathogens, 9(9), e1003667. (doi:10.1371/journal.ppat.1003667)

Wilson, S.J., Schoggins, J.W., Zang, T., Kutluay, S.B., Jouvenet, N., Alim, M., Bitzegeio, J., Rice, C.M. and Bieniasz, P.D. (2012) Inhibition of HIV-1 Particle Assembly by 2′,3′-Cyclic-Nucleotide 3′-Phosphodiesterase. Cell Host and Microbe, 12(4), pp. 585-597. (doi:10.1016/j.chom.2012.08.012)

Wilson, S.J., Schoggins, J.W., Zang, T., Kutluay, S.B., Jouvenet, N., Alim, M.A., Bitzegeio, J., Rice, C.M. and Bieniasz, P.D. (2012) Inhibition of HIV-1 particle assembly by 2′,3′-cyclic-nucleotide 3′-phosphodiesterase. Cell Host and Microbe, 12(4), pp. 585-597. (doi:10.1016/j.chom.2012.08.012)

Yadav, S.S., Wilson, S.J. and Bieniasz, P.D. (2012) A facile quantitative assay for viral particle genesis reveals cooperativity in virion assembly and saturation of an antiviral protein. Virology, 429(2), pp. 155-162. (doi:10.1016/j.virol.2012.04.008)

Zhang, F., Zang, T., Wilson, S.J., Johnson, M.C. and Bieniasz, P.D. (2011) Clathrin facilitates the morphogenesis of retrovirus particles. PLoS Pathogens, 7(6), e1002119. (doi:10.1371/journal.ppat.1002119)

Pardieu, C., Vigan, R., Wilson, S.J., Calvi, A., Zang, T., Bieniasz, P., Kellam, P., Towers, G.J. and Neil, S.J.D. (2010) The RING-CH ligase K5 antagonizes restriction of KSHV and HIV-1 particle release by mediating ubiquitin-dependent endosomal degradation of tetherin. PLoS Pathogens, 6(4), e1000843. (doi:10.1371/journal.ppat.1000843)

Schoggins, J.W., Wilson, S.J., Panis, M., Murphy, M., Jones, C.T., Bieniasz, P.D. and Rice, C.M. (2010) A diverse range of gene products are effectors of the type I interferon antiviral response. Nature, 472(7344), pp. 481-485. (doi:10.1038/nature09907)

Price, A. J., Marzetta, F., Lammers, M., Ylinen, L.M.J., Schaller, T., Wilson, S.J., Towers, G.J. and James, L.C. (2009) Active site remodeling switches HIV specificity of antiretroviral TRIMCyp. Nature Structural and Molecular Biology, 16(10), pp. 1036-42. (doi:10.1038/nsmb.1667)

Dalton-Griffin, L., Wilson, S.J. and Kellam, P. (2009) X-box binding protein 1 contributes to induction of the Kaposi's sarcoma-associated herpesvirus lytic cycle under hypoxic conditions. Journal of Virology, 83(14), pp. 7202-7209. (doi:10.1128/JVI.00076-09)

Zaitseva, L., Cherepanov, P., Leyens, L., Wilson, S.J., Rasaiyaah, J. and Fassati, A. (2009) HIV-1 exploits importin 7 to maximize nuclear import of its DNA genome. Retrovirology, 6(11), (doi:10.1186/1742-4690-6-11)

Zhang, F., Wilson, S.J., Landford, W.C., Virgen, B., Gregory, D., Johnson, M.C., Munch, J., Kirchoff, F., Bieniasz, P.D. and Hatziioannou, T. (2009) Nef proteins from simian immunodeficiency viruses are tetherin antagonists. Cell Host and Microbe, 6(1), pp. 54-67. (doi:10.1016/j.chom.2009.05.008)

Wilson, S.J., Webb, B.L.J., Maplanka, C., Newman, R.M., Verschoor, E.J., Heeney, J.L. and Towers, G.J. (2008) Rhesus macaque TRIM5 alleles have divergent antiretroviral specificities. Journal of Virology, 82(14), pp. 7243-7247. (doi:10.1128/JVI.00307-08)

Wilson, S.J., Webb, B.L.J., Ylinen, L.M., Verschoor, E., Heeney, J.L. and Towers, G.J. (2008) Independent evolution of an antiviral TRIMCyp in rhesus macaques. Proceedings of the National Academy of Sciences of the United States of America, 105(9), 3557 -3562. (doi:10.1073/pnas.0709003105)

Wilson, S.J., Tsao, E.H., Webb, B.L.J., Ye, H., Dalton-Griffin, L., Tsantoulas, C., Gale, C.V., Du, M.-Q., Whitehouse, A. and Kellam, P. (2007) X box binding protein XBP-1s transactivates the Kaposi's sarcoma-associated herpesvirus (KSHV) ORF50 promoter, linking plasma cell differentiation to KSHV reactivation from latency. Journal of Virology, 81(24), pp. 13578-13586. (doi:10.1128/JVI.01663-07)

Clements, M.O., Godfrey, A., Crossley, J., Wilson, S.J., Takeuchi, Y. and Boshoff, C. (2006) Lentiviral manipulation of gene expression in human adult and embryonic stem cells. Tissue Engineering, 12(7), pp. 1741-1751. (doi:10.1089/ten.2006.12.1741)

Ylinen, L.M.J., Keckesova, Z., Wilson, S.J., Ranasinghe, S. and Towers, G.J. (2005) Differential restriction of human immunodeficiency virus type 2 and simian immunodeficiency virus SIVmac by TRIM5alpha alleles. Journal of Virology, 79(18), pp. 11580-11587. (doi:10.1128/JVI.79.18.11580-11587.2005)

This list was generated on Fri Oct 20 07:53:27 2017 BST.

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