Professor Rob Nibbs

  • Professor of Chemokine Biology (Immunology & Infection)

telephone: 01413303960
email: Robert.Nibbs@glasgow.ac.uk

Room B326 Level B3, Iii - Gbrc, University Place, Glasgow G12 8TA

Import to contacts

ORCID iDhttps://orcid.org/0000-0002-8150-0044

Research interests

Our research is broadly aimed at understanding the biological and pathological roles played by chemokines and their receptors.  These important molecules control leukocyte migration and function, and are implicated in a spectrum of diseases, from allergy and autoimmunity, to cancer and infectious disease.  
We study several chemokine receptors, but we are particularly focused on dissecting the biochemical, physiological, and pathological function of ‘atypical’ chemokine receptors (ACKRs). Our work has revealed that these unusual molecules do not directly mediate leukocyte migration, but instead act to control chemokine abundance and distribution to regulate responses mediated by conventional chemokine receptors.
ACKRs are emerging as key regulators of chemokine networks in a range of developmental, homeostatic, and inflammatory contexts, and our work has led us to study diverse biological processes, including reproduction, infection, tissue inflammation, adaptive immune responses, and the development of cancer.
Our studies have also nurtured an ongoing interest in the biology of lymphatic endothelial cells. These cells, which are prominent sites of ACKR expression, line lymphatic vessels and control the movement of immune cells, pathogens, molecules and metastatic cells from tissues to lymph nodes.

Productive collaborations are established with researchers locally, nationally and internationally, and our research has been generously supported by several biomedical funding agencies, including Cancer Research UK, Arthritis Research UK, MRC, BBSRC, and the Wellcome Trust.  
We are always keen to hear from researchers and students interested in studying chemokines and cell migration, and Prof Nibbs can be contacted by email on Robert.nibbs@glasgow.ac.uk

Publications

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Number of items: 100.

2024

Nair, R., Lannagan, T. R.M., Jackstadt, R., Andrusaite, A., Cole, J., Boyne, C., Nibbs, R. J.B. , Sansom, O. J. and Milling, S. (2024) Co-inhibition of TGF-β and PD-L1 pathways in a metastatic colorectal cancer mouse model triggers interferon responses, innate cells and T cells, alongside metabolic changes and tumor resistance. OncoImmunology, 13(1), 2330194. (doi: 10.1080/2162402X.2024.2330194)

2023

McIntyre, K. , Sherry, L. , Stapleton, G. , Latkovskis, I., McDonnell, N. , Nibbs, R. , Douce, G. and Milling, S. (2023) Can Virtual Reality (VR) enhance students’ learning experience? Journal of Perspectives in Applied Academic Practice, 11(3), pp. 3-9. (doi: 10.56433/jpaap.v11i3.573)

Stapleton, G. , McIntyre, K. , Sherry, L. , Douce, G. , Milling, S. , Nibbs, R. , Latkovskis, I., Donald, C. and McDonnell, N. (2023) ‘I felt as if I was there’ - Can Virtual Reality (VR) Enhance Students’ Learning Experience of Immunology Teaching? AMEE Glasgow 2023, Glasgow, UK, 26-30 August 2023.

Pærregaard, S. I. et al. (2023) The small and large intestine contain related mesenchymal subsets that derive from embryonic Gli1+ precursors. Nature Communications, 14, 2307. (doi: 10.1038/s41467-023-37952-5) (PMID:37085516) (PMCID:PMC10121680)

McIntyre, K. , Stapleton, G. , Sherry, L. , Donald, C. , Milling, S. , Nibbs, R. , Douce, G. , Latkovskis, I. and McDonnell, N. (2023) ‘I felt as if I was there’ - Can Virtual Reality (VR) Enhance Students’ Learning Experience of Immunology Teaching? 16th Annual University of Glasgow Learning and Teaching Conference, 29 Mar 2023. (Unpublished)

2022

Naylor, G., Julian, L., Watson-Bryce, S., Mullin, M., Nibbs, R. J. and Olson, M. F. (2022) Immunogenic death of hepatocellular carcinoma cells in mice expressing caspase-resistant ROCK1 is not replicated by ROCK inhibitors. Cancers, 14(23), 5943. (doi: 10.3390/cancers14235943) (PMID:36497425) (PMCID:PMC9740421)

Bonneuil, W., Watson, D., Frattolin, J., Russell, M. J., Fasanella Masci, F., Bandara, M. , Brook, B. S., Nibbs, R. J.B. and Moore, J. (2022) Generation of stable advective-diffusive chemokine gradients in a three-dimensional hydrogel. AIP Advances, 12(2), 025121. (doi: 10.1063/5.0064947)

2021

Frattolin, J., Watson, D. J., Bonneuil, W. V., Russell, M. J., Fasanella Masci, F., Bandara, M. , Brook, B. S., Nibbs, R. and Moore, J. E. (2021) The critical importance of spatial and temporal scales in designing and interpreting immune cell migration assays. Cells, 10(12), e3439. (doi: 10.3390/cells10123439) (PMID:34943947) (PMCID:PMC8700135)

2020

Menzies, F. M., Oldham, R. S., Waddell, C., Nelson, S. M. and Nibbs, R. J.B. (2020) A comprehensive profile of chemokine gene expression in the tissues of the female reproductive tract in mice. Immunological Investigations, 49(3), pp. 264-286. (doi: 10.1080/08820139.2019.1655573) (PMID:31429329)

2019

Collins, P. E., Somma, D. , Kerrigan, D., Herrington, F., Keeshan, K. R. , Nibbs, R. J.B. and Carmody, R. J. (2019) The IκB-protein BCL-3 controls toll-like receptor-induced MAPK activity by promoting TPL-2 degradation in the nucleus. Proceedings of the National Academy of Sciences of the United States of America, 116(51), pp. 25828-25838. (doi: 10.1073/pnas.1900408116) (PMID:31772019) (PMCID:PMC6926074)

Wang, C., Baer, H. M., Gaya, D. R., Nibbs, R. J.B. and Milling, S. (2019) Can molecular stratification improve the treatment of inflammatory bowel disease? Pharmacological Research, 148, 104442. (doi: 10.1016/j.phrs.2019.104442) (PMID:31491469) (PMCID:PMC6902263)

Shergold, A. L., Millar, R. and Nibbs, R. J.B. (2019) Understanding and overcoming the resistance of cancer to PD-1/PD-L1 blockade. Pharmacological Research, 145, 104258. (doi: 10.1016/j.phrs.2019.104258) (PMID:31063806)

2018

Hansell, C. A.H. et al. (2018) The atypical chemokine receptor Ackr2 constrains NK cell migratory activity and promotes metastasis. Journal of Immunology, 201(8), pp. 2510-2519. (doi: 10.4049/jimmunol.1800131) (PMID:30158126) (PMCID:PMC6176105)

Bird, T. G. et al. (2018) TGFβ inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence. Science Translational Medicine, 10(454), eaan1230. (doi: 10.1126/scitranslmed.aan1230) (PMID:30111642) (PMCID:PMC6420144)

Hughes, C. E. and Nibbs, R. J.B. (2018) A guide to chemokines and their receptors. FEBS Journal, 285(16), pp. 2944-2971. (doi: 10.1111/febs.14466) (PMID:29637711) (PMCID:PMC6120486)

Thomson, C. A., van de Pavert, S. A., Stakenborg, M., Labeeuw, E., Matteoli, G., Mowat, A. M. and Nibbs, R. J.B. (2018) Expression of the atypical chemokine receptor ACKR4 identifies a novel population of intestinal submucosal fibroblasts that preferentially expresses endothelial cell regulators. Journal of Immunology, 201(1), pp. 215-229. (doi: 10.4049/jimmunol.1700967) (PMID:29760193) (PMCID:PMC6013047)

Moore, J. E., Brook, B. S. and Nibbs, R. J.B. (2018) Chemokine transport dynamics and emerging recognition of their role in immune function. Current Opinion in Biomedical Engineering, 5, pp. 90-95. 30320240. (doi: 10.1016/j.cobme.2018.03.001) (PMID:PMC6176735)

Wilson, R. A.M., Evans, T.R. J. , Fraser, A. R. and Nibbs, R. J.B. (2018) Immune checkpoint inhibitors: new strategies to checkmate cancer. Clinical and Experimental Immunology, 191(2), pp. 133-148. (doi: 10.1111/cei.13081) (PMID:29139554)

Kara, E. E. et al. (2018) Atypical chemokine receptor 4 shapes activated B cell fate. Journal of Experimental Medicine, 215(3), pp. 801-813. (doi: 10.1084/jem.20171067) (PMID:29386231)

Onyiaodike, C. C. et al. (2018) Pre-conception maternal erythrocyte saturated to unsaturated fatty acid ratio predicts pregnancy after natural cycle frozen embryo transfer. Scientific Reports, 8, 1216. (doi: 10.1038/s41598-018-19500-0) (PMID:29352147) (PMCID:PMC5775249)

2017

Jafarnejad, M., Zawieja, D. C., Brook, B. S., Nibbs, R. J.B. and Moore, Jr., J. E. (2017) A novel computational model predicts key regulators of chemokine gradient formation in lymph nodes and site-specific roles for CCL19 and ACKR4. Journal of Immunology, 199(7), pp. 2291-2304. (doi: 10.4049/jimmunol.1700377) (PMID:28807994) (PMCID:PMC5602158)

HULME, H. E. et al. (2017) Mass spectrometry imaging identifies palmitoylcarnitine as an immunological mediator during Salmonella Typhimurium infection. Scientific Reports, 7, 2786. (doi: 10.1038/s41598-017-03100-5) (PMID:28584281) (PMCID:PMC5459799)

2016

Steele, C. W. et al. (2016) CXCR2 inhibition profoundly suppresses metastases and augments immunotherapy in pancreatic ductal adenocarcinoma. Cancer Cell, 29(6), pp. 832-845. (doi: 10.1016/j.ccell.2016.04.014) (PMID:27265504) (PMCID:PMC4912354)

Herrington, F. D. and Nibbs, R. J.B. (2016) Regulation of the adaptive immune response by the IκB family protein Bcl-3. Cells, 5(2), 14. (doi: 10.3390/cells5020014) (PMID:27023613) (PMCID:PMC4931663)

Bryce, S. A., Wilson, R. A.M., Tiplady, E. M. , Asquith, D. L., Bromley, S. K., Luster, A. D., Graham, G. J. and Nibbs, R. J.B. (2016) ACKR4 on stromal cells scavenges CCL19 to enable CCR7-dependent trafficking of APCs from inflamed skin to lymph nodes. Journal of Immunology, 196(8), pp. 3341-3353. (doi: 10.4049/jimmunol.1501542) (PMID:26976955)

Meyer, B. J., Onyiaodike, C. C., Brown, E. A., Jordan, F., Murray, H., Nibbs, R. J. B. , Sattar, N. , Lyall, H., Nelson, S. M. and Freeman, D. J. (2016) Maternal plasma DHA levels increase prior to 29 days post-LH surge in women undergoing frozen embryo transfer: a prospective, observational study of human pregnancy. Journal of Clinical Endocrinology and Metabolism, 101(4), pp. 1745-1753. (doi: 10.1210/jc.2015-3089) (PMID:26895389)

2015

Serrels, A. et al. (2015) Nuclear FAK controls chemokine transcription, tregs, and evasion of anti-tumor immunity. Cell, 163(1), pp. 160-173. (doi: 10.1016/j.cell.2015.09.001) (PMID:26406376) (PMCID:PMC4597190)

Steele, C. et al. (2015) CXCR2 inhibition suppresses acute and chronic pancreatic inflammation. Journal of Pathology, 237(1), pp. 85-97. (doi: 10.1002/path.4555) (PMID:25950520)

Bachelerie, F., Graham, G.J. , Locati, M., Mantovani, A., Murphy, P.M., Nibbs, R. , Rot, A., Sozzani, S. and Thelen, M. (2015) An atypical addition to the chemokine receptor nomenclature: IUPHAR Review 15. British Journal of Pharmacology, 172(16), pp. 3945-3949. (doi: 10.1111/bph.13182) (PMID:25958743)

Oliver-Bell, J., Butcher, J.P., Malcolm, J. , Macleod, M.K.L. , Adrados Planell, A., Campbell, L., Nibbs, R.J.B. , Garside, P. , McInnes, I.B. and Culshaw, S. (2015) Periodontitis in the absence of B cells and specific anti-bacterial antibody. Oral Microbiology and Immunology, 30(2), pp. 160-169. (doi: 10.1111/omi.12082) (PMID:25219939)

Asquith, D. L., Bryce, S. A. and Nibbs, R. J.B. (2015) Targeting cell migration in rheumatoid arthritis. Current Opinion in Rheumatology, 27(2), pp. 204-211. (doi: 10.1097/BOR.0000000000000150) (PMID:25603038)

Hansell, C. A., MacLellan, L. M., Oldham, R. S., Doonan, J., Chapple, K. J., Anderson, E. J., Linington, C. , McInnes, I. B. , Nibbs, R. J. and Goodyear, C. S. (2015) The atypical chemokine receptor ACKR2 suppresses Th17 responses to protein autoantigens. Immunology and Cell Biology, 93(2), pp. 167-176. (doi: 10.1038/icb.2014.90) (PMID:25348934) (PMCID:PMC4340511)

Lucas, B., White, A. J., Ulvmar, M. H., Nibbs, R. J.B. , Sitnik, K. M., Agace, W. W., Jenkinson, W. E., Anderson, G. and Rot, A. (2015) CCRL1/ACKR4 is expressed in key thymic microenvironments but is dispensable for T lymphopoiesis at steady state in adult mice. European Journal of Immunology, 45(2), pp. 574-583. (doi: 10.1002/eji.201445015) (PMID:25521433)

2014

Teoh, P. J., Menzies, F. M., Hansell, C. A.H., Clarke, M. , Waddell, C., Burton, G. J., Nelson, S. M. and Nibbs, R. J.B. (2014) Atypical chemokine receptor ACKR2 mediates chemokine scavenging by primary human trophoblasts and can regulate fetal growth, placental structure, and neonatal mortality in mice. Journal of Immunology, 193(10), pp. 5218-5228. (doi: 10.4049/jimmunol.1401096)

Lee, K. M., Danuser, R., Stein, J. V., Graham, D. , Nibbs, R. J.B. and Graham, G. J. (2014) The chemokine receptors ACKR2 and CCR2 reciprocally regulate lymphatic vessel density. EMBO Journal, 33(21), pp. 2564-2580. (doi: 10.15252/embj.201488887)

Ford, L. B., Cerovic, V., Milling, S. W.F. , Graham, G. J. , Hansell, C. A.H. and Nibbs, R. J.B. (2014) Characterization of conventional and atypical receptors for the chemokine CCL2 on mouse leukocytes. Journal of Immunology, 193(1), pp. 400-411. (doi: 10.4049/jimmunol.1303236)

Le Brocq, M. L., Fraser, A. R., Cotton, G., Woznica, K., McCulloch, C. V., Hewit, K. D., McKimmie, C. S., Nibbs, R. J.B. , Campbell, J. D.M. and Graham, G. J. (2014) Chemokines as novel and versatile reagents for flow cytometry and cell sorting. Journal of Immunology, 192(12), pp. 6120-6130. (doi: 10.4049/jimmunol.1303371) (PMID:24850722)

Hewit, K. D., Fraser, A., Nibbs, R. J.B. and Graham, G. J. (2014) The N-terminal region of the atypical chemokine receptor ACKR2 is a key determinant of ligand binding. Journal of Biological Chemistry, 289(18), pp. 12330-12342. (doi: 10.1074/jbc.M113.534545)

Patterson, H., Nibbs, R. , McInnes, I. and Siebert, S. (2014) Protein kinase inhibitors in the treatment of inflammatory and autoimmune diseases. Clinical and Experimental Immunology, 176(1), pp. 1-10. (doi: 10.1111/cei.12248)

Bachelerie, F., Graham, G.J. , Locati, M., Mantovani, A., Murphy, P.M., Nibbs, R. , Rot, A., Sozzani, S. and Thelen, M. (2014) New nomenclature for atypical chemokine receptors. Nature Immunology, 15(3), pp. 207-208. (doi: 10.1038/ni.2812)

Bachelerie, F. et al. (2014) International union of pharmacology. LXXXIX. update on the extended family of chemokine receptors and introducing a new nomenclature for atypical chemokine receptors. Pharmacological Reviews, 66(1), pp. 1-79. (doi: 10.1124/pr.113.007724)

Ulvmar, M. H. et al. (2014) The atypical chemokine receptor CCRL1 shapes functional CCL21 gradients in lymph nodes. Nature Immunology, 15(7), pp. 623-630. (doi: 10.1038/ni.2889) (PMID:24813163)

2013

Baldwin, H.M., Pallas, K., King, V., Jamieson, T., McKimmie, C.S., Nibbs, R.J.B. , Carballido, J.M., Jaritz, M., Rot, A. and Graham, G.J. (2013) Microarray analyses demonstrate the involvement of type i interferons in psoriasiform pathology development in D6-deficient mice. Journal of Biological Chemistry, 288(51), pp. 36473-36483. (doi: 10.1074/jbc.M113.491563)

O'Carroll, C., Moloney, G., Hurley, G., Melgar, S., Brint, E., Nally, K., Nibbs, R.J. , Shanahan, F. and Carmody, R.J. (2013) Bcl-3 deficiency protects against dextran-sodium sulphate-induced colitis in the mouse. Clinical and Experimental Immunology, 173(2), pp. 332-342. (doi: 10.1111/cei.12119) (PMID:23607276)

Ford, L. B., Hansell, C. A.H. and Nibbs, R. J.B. (2013) Using fluorescent chemokine uptake to detect chemokine receptors by fluorescent activated cell sorting. In: Cardona, A. E. and Ubogu, E. E. (eds.) Chemokines: Methods and Protocols. Series: Methods in Molecular Biology, 1013 (1013). Humana Press Inc.: New York, NY, pp. 203-214. ISBN 9781627034258 (doi: 10.1007/978-1-62703-426-5_13)

Rot, A., McKimmie, C., Burt, C.L., Pallas, K.J., Jamieson, T., Pruenster, M., Horuk, R., Nibbs, R.J.B. and Graham, G.J. (2013) Cell-autonomous regulation of neutrophil migration by the D6 chemokine decoy receptor. Journal of Immunology, 190(12), pp. 6450-6456. (doi: 10.4049/jimmunol.1201429)

McKimmie, C.S. et al. (2013) An analysis of the function and expression of D6 on lymphatic endothelial cells. Blood, 121(18), pp. 3768-3777. (doi: 10.1182/blood-2012-04-425314)

Bunting, M.D., Comerford, I., Seach, N., Hammett, M. V., Asquith, D.L., Korner, H., Boyd, R. L., Nibbs, R.J.B. and McColl, S. R. (2013) CCX-CKR deficiency alters thymic stroma impairing thymocyte development and promoting autoimmunity. Blood, 121(1), pp. 118-128. (doi: 10.1182/blood-2012-06-434886)

Lee, K., Nibbs, R.J.B. and Graham, G.J. (2013) D6: the 'crowd controller’ at the immune gateway. Trends in Immunology, 34(1), pp. 7-12. (doi: 10.1016/j.it.2012.08.001)

Oleinika, K., Nibbs, R.J. , Graham, G.J. and Fraser, A.R. (2013) Suppression, subversion and escape: the role of regulatory T cells in cancer progression. Clinical and Experimental Immunology, 171(1), pp. 36-45. (doi: 10.1111/j.1365-2249.2012.04657.x)

Nibbs, R.J.B. and Graham, G.J. (2013) Immune regulation by atypical chemokine receptors. Nature Reviews Immunology, 13(11), pp. 815-829. (doi: 10.1038/nri3544)

2012

Jamieson, T. et al. (2012) Inhibition of CXCR2 profoundly suppresses inflammation-driven and spontaneous tumorigenesis. Journal of Clinical Investigation, 122(9), pp. 3127-3144. (doi: 10.1172/JCI61067)

Menzies, F.M., Higgins, C.A., Shepherd, M.C., Nibbs, R.J.B. and Nelson, S.M. (2012) Mast cells reside in myometrium and cervix, but are dispensable in mice for successful pregnancy and labor. Immunology and Cell Biology, 90, pp. 321-329. (doi: 10.1038/icb.2011.40)

Menzies, F. M., Khan, A. H., Higgins, C. A., Nelson, S. M. and Nibbs, R. J. B. (2012) The chemokine receptor CCR2 is not required for successful initiation of labor in mice. Biology of Reproduction, 86(4), p. 118. (doi: 10.1095/biolreprod.111.094631)

2011

Lee, K. M. et al. (2011) D6 facilitates cellular migration and fluid flow to lymph nodes by suppressing lymphatic congestion. Blood, 118(23), pp. 6220-6229. (doi: 10.1182/blood-2011-03-344044)

MacLellan, L. M., Montgomery, J., Sugiyama, F., Kitson, S. M., Thümmler, K. , Silverman, G. J., Beers, S. A., Nibbs, R. J.B. , McInnes, I. B. and Goodyear, C. S. (2011) Co-opting endogenous immunoglobulin for the regulation of inflammation and osteoclastogenesis in humans and mice. Arthritis and Rheumatism, 63(12), pp. 3897-3907. (doi: 10.1002/art.30629) (PMID:22127707) (PMCID:PMC3598489)

Hansell, C.A.H. and Nibbs, R.J.B. (2011) The odd couple: innate-like B cells and the chemokine scavenger D6. Cell Cycle, 10(21), pp. 3619-3620. (doi: 10.4161/cc.10.21.17851)

Hansell, C. A. H., Schiering, C., Kinstrie, R., Ford, L., Bordon, Y., McInnes, I. B. , Goodyear, C. S. and Nibbs, R. J.B. (2011) Universal expression and dual function of the atypical chemokine receptor D6 on innate-like B cells in mice. Blood, 117(20), pp. 5413-5424. (doi: 10.1182/blood-2010-11-317115) (PMID:21450903) (PMCID:PMC3188399)

Hansell, C.A.H., Hurson, C.E. and Nibbs, R.J.B. (2011) DARC and D6: silent partners in chemokine regulation? Immunology and Cell Biology, 89(2), pp. 197-206. (doi: 10.1038/icb.2010.147) (PMID:21151196) (PMCID:PMC3041651)

Menzies, F.M., Shepherd, M.C., Nibbs, R.J. and Nelson, S.M. (2011) The role of mast cells and their mediators in reproduction, pregnancy and labour. Human Reproduction Update, 17(3), pp. 383-396. (doi: 10.1093/humupd/dmq053)

2010

Comerford, I., Nibbs, R. , Litchfield, W., Bunting, M., Harata-Lee, Y., Haylock-Jacobs, S., Forrow, S., Korner, H. and McColl, S.R. (2010) The atypical chemokine receptor CCX-CKR scavenges homeostatic chemokines in circulation and tissues and suppresses Th17 responses. Blood, 116(20), pp. 4130-4140. (doi: 10.1182/blood-2010-01-264390)

Singh, M., Nibbs, R.J. and Graham, G.J. (2010) The atypical chemokine receptors. In: Smit, M.J., Lira, S.A. and Leurs, R. (eds.) Chemokine Receptors as Drug Targets. Wiley-VCH: Weinheim, Germany. ISBN 9783527632008

Leick, M., Catusse, J., Follo, M., Nibbs, R.J. , Hartmann, T.N., Veelken, H. and Burger, M. (2010) CCL19 is a specific ligand of the constitutively recycling atypical human chemokine receptor CRAM-B. Immunology, 129(4), pp. 536-546. (doi: 10.1111/j.1365-2567.2009.03209.x)

Henriques, C. M., Rino, J., Nibbs, R. J. , Graham, G. J. and Barata, J. T. (2010) IL-7 induces rapid clathrin-mediated internalization and JAK3-dependent degradation of IL-7R alpha in T cells. Blood, 115(16), pp. 3269-3277. (doi: 10.1182/blood-2009-10-246876)

Madigan, J. et al. (2010) Chemokine Scavenger D6 Is Expressed by Trophoblasts and Aids the Survival of Mouse Embryos Transferred into Allogeneic Recipients. Journal of Immunology, 184(6), pp. 3202-3212. (doi: 10.4049/jimmunol.0902118)

Menzies, F.M., Shepherd, M.C., Nibbs, R.J. and Nelson, S.M. (2010) The role of mast cells and their mediators in reproduction, pregnancy and labour. Human Reproduction Update, 17(3), pp. 383-396. (doi: 10.1093/humupd/dmq0532)

2009

Nibbs, R.J. (2009) HIV: getting to the heart of DARCness. Blood, 114(13), p. 2783.

Alexander-Sefre, F., Nibbs, R.J. , Rafferty, T., Ayhan, A., Singh, N. and Jacobs, I. (2009) Clinical value of immunohistochemically detected lymphatic and vascular invasions in clinically staged endometrioid endometrial cancer. International Journal of Gynecological Cancer, 19(6), pp. 1074-1079. (doi: 10.1111/IGC.0b013e3181abb0c0)

McKimmie, C. S. et al. (2009) A TLR2 ligand suppresses inflammation by modulation of chemokine receptors and redirection of leukocyte migration. Blood, 113(18), pp. 4224-4231. (doi: 10.1182/blood-2008-08-174698) (PMID:19202130)

Bordon, Y., Hansell, C. A. H., Sester, D. P., Clarke, M. , Mowat, A. M. and Nibbs, R. J. B. (2009) The atypical chemokine receptor D6 contributes to the development of experimental colitis. Journal of Immunology, 182(8), pp. 5032-5040. (doi: 10.4049/jimmunol.0802802)

He, W. et al. (2009) Reply to: “Experimental aspects of copy number variant assays at CCL3L1”. Nature Medicine, 15(10), pp. 1117-1120. (doi: 10.1038/nm1009-1117)

Nibbs, R. J.B. , McLean, P., McCulloch, C., Riboldi‐Tunnicliffe, A., Blair, E., Zhu, Y., Isaacs, N. and Graham, G. J. (2009) Structure–function dissection of D6, an atypical scavenger receptor. In: Abelson, J. N. and Simon, M. I. (eds.) Chemokines, Part A. Series: Methods in enzymology (460). Academic Press: Amsterdam, pp. 245-261. ISBN 9780123749086 (doi: 10.1016/S0076-6879(09)05212-4)

Pruenster, M. et al. (2009) The Duffy antigen receptor for chemokines transports chemokines and supports their promigratory activity. Nature Immunology, 10(1), pp. 101-108. (doi: 10.1038/ni.1675)

2008

McKimmie, C. S. et al. (2008) Hemopoietic cell expression of the chemokine decoy receptor D6 is dynamic and regulated by GATA1. Journal of Immunology, 181(5), pp. 3353-3363. (doi: 10.4049/jimmunol.181.11.8170-a) (PMID:19039854)

McCulloch, C., Morrow, V., Milasta, S., Comerford, I., Milligan, G. , Graham, G. , Isaacs, N. and Nibbs, R. (2008) Multiple roles for the C-terminal tail of the chemokine scavenger D6. Journal of Biological Chemistry, 283(12), pp. 7972-7982. (doi: 10.1074/jbc.M710128200)

Truman, L. et al. (2008) CX3CL1/fractalkine is released from apoptotic lymphocytes to stimulate macrophage chemotaxis. Blood, 112(13), pp. 5026-5036. (doi: 10.1182/blood-2008-06-162404)

2007

Kosta, K., Sabroe, I., Göke, J., Nibbs, R. J.D. , Tsanakas, J., Whyte, M. K. and Teare, M. D. (2007) A Bayesian approach to copy-number-polymorphism analysis in nuclear pedigrees. American Journal of Human Genetics, 81(4), pp. 808-812. (doi: 10.1086/520096)

Nibbs, R. J.B. , Gilchrist, D. S., King, V., Ferra, A., Forrow, S., Hunter, K. D. and Graham, G. J. (2007) The atypical chemokine receptor D6 suppresses the development of chemically induced skin tumors. Journal of Clinical Investigation, 117(7), pp. 1884-1892. (doi: 10.1172/JCI30068)

Comerford, I., Harata-Lee, Y., Litchfield, W., Mccoll, S. and Nibbs, R. (2007) Regulation of chemotactic networks by 'atypical' receptors. BioEssays, 29, pp. 237-247. (doi: 10.1002/bies.20537)

Graham, G.J. and Nibbs, R.J. (2007) Chemokine receptors: a structural overview. In: Harrison, J.K. and Lukacs, N.W. (eds.) The Chemokine Receptors. Series: Receptors. Humana Press: Totowa, NJ, pp. 31-54. ISBN 978-1-58829-773-0

Hansell, C. and Nibbs, R. (2007) Professional and Part-Time Chemokine Decoys in the Resolution of Inflammation. Science's Stke, 2007(384), e18. (doi: 10.1126/stke.3842007pe18)

2006

Comerford, I., Milasta, S., Morrow, V., Milligan, G. and Nibbs, R. (2006) The chemokine receptor CCX-CKR mediates effective scavenging of CCL19 in vitro. European Journal of Immunology, 36(7), pp. 1904-1916. (doi: 10.1002/eji.200535716)

Cook, G., Harrison, S., Nibbs, R. and Prince, H. (2006) Immunotherapy of multiple myeloma: the start of a long and tortuous journey. Expert Review of Anticancer Therapy, 6, pp. 1769-1785. (doi: 10.1586/14737140.6.12.1769)

Hansell, C., Nibbs, R. and Simpson, C. (2006) Chernokine sequestration by atypical chemokine receptors. Biochemical Society Transactions, 34, pp. 1009-1013.

2005

Kuroumalis, A., Nibbs, R. J. , Aptel, H., Wright, K. L., Kolios, G. and Ward, S. G. (2005) The chemokines CXCL9, CXCL10, and CXCL11 differentially stimulate G alpha(i)-independent signaling and actin responses in human intestinal myofibroblasts. Journal of Immunology, 175, pp. 5403-5411.

Comerford, L. and Nibbs, R. (2005) Post-translational control of chemokines: a role for,decoy receptors? Immunology Letters, 96, pp. 163-174. (doi: 10.1016/j.imlet.2004.08.018)

Gonzalez, E. et al. (2005) The influence of CCL3L1 gene-containing segmental duplications on HIV-1/AIDS susceptibility. Science, 307(5714), pp. 1434-1440.

Jamieson, T., Cook, D. N., Nibbs, R. J.B. , Rot, A., Nixon, C., Mclean, P., Alcami, A., Lira, S. A., Wiekowski, M. and Graham, G. J. (2005) The chemokine receptor D6 limits the inflammatory response in vivo. Nature Immunology, 6, pp. 403-411. (doi: 10.1038/ni1182)

Neil, S., Aasa-Chapman, M., Clapham, P., Nibbs, R. , McKnight, A. and Weiss, R. (2005) The promiscuous CC chemokine receptor D6 is a functional coreceptor for primary isolates of human immunodeficiency virus type 1 (HIV-1) and HIV-2 on astrocytes. Journal of Virology, 79, pp. 9618-9624. (doi: 10.1128/JVI.79.15.9618-9624.2005)

2004

Weber, M., Blair, E., Simpson, C. V., O'Hara, M., Blackburn, P. E., Rot, A., Graham, G. J. and Nibbs, R. J.B. (2004) The chemokine receptor D6 constitutively traffics to and from the cell surface to internalize and degrade chemokine. Molecular Biology of the Cell, 15(5), pp. 2492-2508. (doi: 10.1091/mbc.E03-09-0634)

Blackburn, P. E., Simpson, C. V., Nibbs, R. J. B. , O'Hara, M., Booth, R., Poulos, J., Isaacs, N. W. and Graham, G. J. (2004) Purification and biochemical characterization of the D6 chemokine receptor. Biochemical Journal, 379(2), p. 263. (doi: 10.1042/BJ20031266)

2003

Chvatchko, Y. et al. (2003) Inhibition of airway inflammation by amino-terminally modified RANTES/CC chemokine ligand 5 analogues is not mediated through CCR3. Journal of Immunology, 171(10), pp. 5498-5506.

Graham, G. and Nibbs, R. (2003) CCL27/PESKY: a novel paradigm for chemokine function. Expert Opinion on Biological Therapy, 3(1), pp. 15-22.

Nibbs, R. , Graham, G. and Rot, A. (2003) Chemokines on the move: control by the chemokine 'interceptors' Duffy blood group antigen and D6. Seminars in Immunology, 15(5), pp. 287-294.

2002

Townson, J. R., Barcellos, L. F. and Nibbs, R. J.B. (2002) Gene copy number regulates the production of the human chemokine CCL3-L1. European Journal of Immunology, 32(10), pp. 3016-3026. (doi: 10.1002/1521-4141(2002010)32:10<3016::AID-IMMU3016>3.0.CO;2-D)

Gortz, A., Nibbs, R. J.B. , McLean, P., Jarmin, D., Lambie, W., Baird, J. W. and Graham, G. J. (2002) The chemokine ESkine/CCL27 displays novel modes of intracrine and paracrine function. Journal of Immunology, 169(3), pp. 1387-1394.

Townson, J. and Nibbs, R. (2002) Characterization of mouse CCX-CKR, a receptor for the lymphocyte-attracting chemokines TECK/mCCL25, SLC/mCCL21 and MIP-3 beta/mCCL19: comparison to human CCX-CKR. European Journal of Immunology, 32(5), pp. 1230-1241.

2001

Nibbs, R. et al. (2001) The beta-chemokine receptor D6 is expressed by lymphatic endothelium and a subset of vascular tumors. American Journal of Pathology, 158, pp. 867-877.

2000

Townson, J. R., Graham, G. J. , Landau, N. R., Rasala, B. and Nibbs, R. J.B. (2000) Aminooxypentane addition to the chemokine macrophage inflammatory Protein-1 alpha P increases receptor affinities and HIV inhibition. Journal of Biological Chemistry, 275(50), pp. 39254-39261. (doi: 10.1074/jbc.M006768200)

Nibbs, R. J.B. et al. (2000) C-C chemokine receptor 3 antagonism by the beta-chemokine macrophage inflammatory protein 4, a property strongly enhanced by an amino-terminal alanine-methionine swap. Journal of Immunology, 164(3), pp. 1488-97.

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Articles

Nair, R., Lannagan, T. R.M., Jackstadt, R., Andrusaite, A., Cole, J., Boyne, C., Nibbs, R. J.B. , Sansom, O. J. and Milling, S. (2024) Co-inhibition of TGF-β and PD-L1 pathways in a metastatic colorectal cancer mouse model triggers interferon responses, innate cells and T cells, alongside metabolic changes and tumor resistance. OncoImmunology, 13(1), 2330194. (doi: 10.1080/2162402X.2024.2330194)

McIntyre, K. , Sherry, L. , Stapleton, G. , Latkovskis, I., McDonnell, N. , Nibbs, R. , Douce, G. and Milling, S. (2023) Can Virtual Reality (VR) enhance students’ learning experience? Journal of Perspectives in Applied Academic Practice, 11(3), pp. 3-9. (doi: 10.56433/jpaap.v11i3.573)

Pærregaard, S. I. et al. (2023) The small and large intestine contain related mesenchymal subsets that derive from embryonic Gli1+ precursors. Nature Communications, 14, 2307. (doi: 10.1038/s41467-023-37952-5) (PMID:37085516) (PMCID:PMC10121680)

Naylor, G., Julian, L., Watson-Bryce, S., Mullin, M., Nibbs, R. J. and Olson, M. F. (2022) Immunogenic death of hepatocellular carcinoma cells in mice expressing caspase-resistant ROCK1 is not replicated by ROCK inhibitors. Cancers, 14(23), 5943. (doi: 10.3390/cancers14235943) (PMID:36497425) (PMCID:PMC9740421)

Bonneuil, W., Watson, D., Frattolin, J., Russell, M. J., Fasanella Masci, F., Bandara, M. , Brook, B. S., Nibbs, R. J.B. and Moore, J. (2022) Generation of stable advective-diffusive chemokine gradients in a three-dimensional hydrogel. AIP Advances, 12(2), 025121. (doi: 10.1063/5.0064947)

Frattolin, J., Watson, D. J., Bonneuil, W. V., Russell, M. J., Fasanella Masci, F., Bandara, M. , Brook, B. S., Nibbs, R. and Moore, J. E. (2021) The critical importance of spatial and temporal scales in designing and interpreting immune cell migration assays. Cells, 10(12), e3439. (doi: 10.3390/cells10123439) (PMID:34943947) (PMCID:PMC8700135)

Menzies, F. M., Oldham, R. S., Waddell, C., Nelson, S. M. and Nibbs, R. J.B. (2020) A comprehensive profile of chemokine gene expression in the tissues of the female reproductive tract in mice. Immunological Investigations, 49(3), pp. 264-286. (doi: 10.1080/08820139.2019.1655573) (PMID:31429329)

Collins, P. E., Somma, D. , Kerrigan, D., Herrington, F., Keeshan, K. R. , Nibbs, R. J.B. and Carmody, R. J. (2019) The IκB-protein BCL-3 controls toll-like receptor-induced MAPK activity by promoting TPL-2 degradation in the nucleus. Proceedings of the National Academy of Sciences of the United States of America, 116(51), pp. 25828-25838. (doi: 10.1073/pnas.1900408116) (PMID:31772019) (PMCID:PMC6926074)

Wang, C., Baer, H. M., Gaya, D. R., Nibbs, R. J.B. and Milling, S. (2019) Can molecular stratification improve the treatment of inflammatory bowel disease? Pharmacological Research, 148, 104442. (doi: 10.1016/j.phrs.2019.104442) (PMID:31491469) (PMCID:PMC6902263)

Shergold, A. L., Millar, R. and Nibbs, R. J.B. (2019) Understanding and overcoming the resistance of cancer to PD-1/PD-L1 blockade. Pharmacological Research, 145, 104258. (doi: 10.1016/j.phrs.2019.104258) (PMID:31063806)

Hansell, C. A.H. et al. (2018) The atypical chemokine receptor Ackr2 constrains NK cell migratory activity and promotes metastasis. Journal of Immunology, 201(8), pp. 2510-2519. (doi: 10.4049/jimmunol.1800131) (PMID:30158126) (PMCID:PMC6176105)

Bird, T. G. et al. (2018) TGFβ inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence. Science Translational Medicine, 10(454), eaan1230. (doi: 10.1126/scitranslmed.aan1230) (PMID:30111642) (PMCID:PMC6420144)

Hughes, C. E. and Nibbs, R. J.B. (2018) A guide to chemokines and their receptors. FEBS Journal, 285(16), pp. 2944-2971. (doi: 10.1111/febs.14466) (PMID:29637711) (PMCID:PMC6120486)

Thomson, C. A., van de Pavert, S. A., Stakenborg, M., Labeeuw, E., Matteoli, G., Mowat, A. M. and Nibbs, R. J.B. (2018) Expression of the atypical chemokine receptor ACKR4 identifies a novel population of intestinal submucosal fibroblasts that preferentially expresses endothelial cell regulators. Journal of Immunology, 201(1), pp. 215-229. (doi: 10.4049/jimmunol.1700967) (PMID:29760193) (PMCID:PMC6013047)

Moore, J. E., Brook, B. S. and Nibbs, R. J.B. (2018) Chemokine transport dynamics and emerging recognition of their role in immune function. Current Opinion in Biomedical Engineering, 5, pp. 90-95. 30320240. (doi: 10.1016/j.cobme.2018.03.001) (PMID:PMC6176735)

Wilson, R. A.M., Evans, T.R. J. , Fraser, A. R. and Nibbs, R. J.B. (2018) Immune checkpoint inhibitors: new strategies to checkmate cancer. Clinical and Experimental Immunology, 191(2), pp. 133-148. (doi: 10.1111/cei.13081) (PMID:29139554)

Kara, E. E. et al. (2018) Atypical chemokine receptor 4 shapes activated B cell fate. Journal of Experimental Medicine, 215(3), pp. 801-813. (doi: 10.1084/jem.20171067) (PMID:29386231)

Onyiaodike, C. C. et al. (2018) Pre-conception maternal erythrocyte saturated to unsaturated fatty acid ratio predicts pregnancy after natural cycle frozen embryo transfer. Scientific Reports, 8, 1216. (doi: 10.1038/s41598-018-19500-0) (PMID:29352147) (PMCID:PMC5775249)

Jafarnejad, M., Zawieja, D. C., Brook, B. S., Nibbs, R. J.B. and Moore, Jr., J. E. (2017) A novel computational model predicts key regulators of chemokine gradient formation in lymph nodes and site-specific roles for CCL19 and ACKR4. Journal of Immunology, 199(7), pp. 2291-2304. (doi: 10.4049/jimmunol.1700377) (PMID:28807994) (PMCID:PMC5602158)

HULME, H. E. et al. (2017) Mass spectrometry imaging identifies palmitoylcarnitine as an immunological mediator during Salmonella Typhimurium infection. Scientific Reports, 7, 2786. (doi: 10.1038/s41598-017-03100-5) (PMID:28584281) (PMCID:PMC5459799)

Steele, C. W. et al. (2016) CXCR2 inhibition profoundly suppresses metastases and augments immunotherapy in pancreatic ductal adenocarcinoma. Cancer Cell, 29(6), pp. 832-845. (doi: 10.1016/j.ccell.2016.04.014) (PMID:27265504) (PMCID:PMC4912354)

Herrington, F. D. and Nibbs, R. J.B. (2016) Regulation of the adaptive immune response by the IκB family protein Bcl-3. Cells, 5(2), 14. (doi: 10.3390/cells5020014) (PMID:27023613) (PMCID:PMC4931663)

Bryce, S. A., Wilson, R. A.M., Tiplady, E. M. , Asquith, D. L., Bromley, S. K., Luster, A. D., Graham, G. J. and Nibbs, R. J.B. (2016) ACKR4 on stromal cells scavenges CCL19 to enable CCR7-dependent trafficking of APCs from inflamed skin to lymph nodes. Journal of Immunology, 196(8), pp. 3341-3353. (doi: 10.4049/jimmunol.1501542) (PMID:26976955)

Meyer, B. J., Onyiaodike, C. C., Brown, E. A., Jordan, F., Murray, H., Nibbs, R. J. B. , Sattar, N. , Lyall, H., Nelson, S. M. and Freeman, D. J. (2016) Maternal plasma DHA levels increase prior to 29 days post-LH surge in women undergoing frozen embryo transfer: a prospective, observational study of human pregnancy. Journal of Clinical Endocrinology and Metabolism, 101(4), pp. 1745-1753. (doi: 10.1210/jc.2015-3089) (PMID:26895389)

Serrels, A. et al. (2015) Nuclear FAK controls chemokine transcription, tregs, and evasion of anti-tumor immunity. Cell, 163(1), pp. 160-173. (doi: 10.1016/j.cell.2015.09.001) (PMID:26406376) (PMCID:PMC4597190)

Steele, C. et al. (2015) CXCR2 inhibition suppresses acute and chronic pancreatic inflammation. Journal of Pathology, 237(1), pp. 85-97. (doi: 10.1002/path.4555) (PMID:25950520)

Bachelerie, F., Graham, G.J. , Locati, M., Mantovani, A., Murphy, P.M., Nibbs, R. , Rot, A., Sozzani, S. and Thelen, M. (2015) An atypical addition to the chemokine receptor nomenclature: IUPHAR Review 15. British Journal of Pharmacology, 172(16), pp. 3945-3949. (doi: 10.1111/bph.13182) (PMID:25958743)

Oliver-Bell, J., Butcher, J.P., Malcolm, J. , Macleod, M.K.L. , Adrados Planell, A., Campbell, L., Nibbs, R.J.B. , Garside, P. , McInnes, I.B. and Culshaw, S. (2015) Periodontitis in the absence of B cells and specific anti-bacterial antibody. Oral Microbiology and Immunology, 30(2), pp. 160-169. (doi: 10.1111/omi.12082) (PMID:25219939)

Asquith, D. L., Bryce, S. A. and Nibbs, R. J.B. (2015) Targeting cell migration in rheumatoid arthritis. Current Opinion in Rheumatology, 27(2), pp. 204-211. (doi: 10.1097/BOR.0000000000000150) (PMID:25603038)

Hansell, C. A., MacLellan, L. M., Oldham, R. S., Doonan, J., Chapple, K. J., Anderson, E. J., Linington, C. , McInnes, I. B. , Nibbs, R. J. and Goodyear, C. S. (2015) The atypical chemokine receptor ACKR2 suppresses Th17 responses to protein autoantigens. Immunology and Cell Biology, 93(2), pp. 167-176. (doi: 10.1038/icb.2014.90) (PMID:25348934) (PMCID:PMC4340511)

Lucas, B., White, A. J., Ulvmar, M. H., Nibbs, R. J.B. , Sitnik, K. M., Agace, W. W., Jenkinson, W. E., Anderson, G. and Rot, A. (2015) CCRL1/ACKR4 is expressed in key thymic microenvironments but is dispensable for T lymphopoiesis at steady state in adult mice. European Journal of Immunology, 45(2), pp. 574-583. (doi: 10.1002/eji.201445015) (PMID:25521433)

Teoh, P. J., Menzies, F. M., Hansell, C. A.H., Clarke, M. , Waddell, C., Burton, G. J., Nelson, S. M. and Nibbs, R. J.B. (2014) Atypical chemokine receptor ACKR2 mediates chemokine scavenging by primary human trophoblasts and can regulate fetal growth, placental structure, and neonatal mortality in mice. Journal of Immunology, 193(10), pp. 5218-5228. (doi: 10.4049/jimmunol.1401096)

Lee, K. M., Danuser, R., Stein, J. V., Graham, D. , Nibbs, R. J.B. and Graham, G. J. (2014) The chemokine receptors ACKR2 and CCR2 reciprocally regulate lymphatic vessel density. EMBO Journal, 33(21), pp. 2564-2580. (doi: 10.15252/embj.201488887)

Ford, L. B., Cerovic, V., Milling, S. W.F. , Graham, G. J. , Hansell, C. A.H. and Nibbs, R. J.B. (2014) Characterization of conventional and atypical receptors for the chemokine CCL2 on mouse leukocytes. Journal of Immunology, 193(1), pp. 400-411. (doi: 10.4049/jimmunol.1303236)

Le Brocq, M. L., Fraser, A. R., Cotton, G., Woznica, K., McCulloch, C. V., Hewit, K. D., McKimmie, C. S., Nibbs, R. J.B. , Campbell, J. D.M. and Graham, G. J. (2014) Chemokines as novel and versatile reagents for flow cytometry and cell sorting. Journal of Immunology, 192(12), pp. 6120-6130. (doi: 10.4049/jimmunol.1303371) (PMID:24850722)

Hewit, K. D., Fraser, A., Nibbs, R. J.B. and Graham, G. J. (2014) The N-terminal region of the atypical chemokine receptor ACKR2 is a key determinant of ligand binding. Journal of Biological Chemistry, 289(18), pp. 12330-12342. (doi: 10.1074/jbc.M113.534545)

Patterson, H., Nibbs, R. , McInnes, I. and Siebert, S. (2014) Protein kinase inhibitors in the treatment of inflammatory and autoimmune diseases. Clinical and Experimental Immunology, 176(1), pp. 1-10. (doi: 10.1111/cei.12248)

Bachelerie, F., Graham, G.J. , Locati, M., Mantovani, A., Murphy, P.M., Nibbs, R. , Rot, A., Sozzani, S. and Thelen, M. (2014) New nomenclature for atypical chemokine receptors. Nature Immunology, 15(3), pp. 207-208. (doi: 10.1038/ni.2812)

Bachelerie, F. et al. (2014) International union of pharmacology. LXXXIX. update on the extended family of chemokine receptors and introducing a new nomenclature for atypical chemokine receptors. Pharmacological Reviews, 66(1), pp. 1-79. (doi: 10.1124/pr.113.007724)

Ulvmar, M. H. et al. (2014) The atypical chemokine receptor CCRL1 shapes functional CCL21 gradients in lymph nodes. Nature Immunology, 15(7), pp. 623-630. (doi: 10.1038/ni.2889) (PMID:24813163)

Baldwin, H.M., Pallas, K., King, V., Jamieson, T., McKimmie, C.S., Nibbs, R.J.B. , Carballido, J.M., Jaritz, M., Rot, A. and Graham, G.J. (2013) Microarray analyses demonstrate the involvement of type i interferons in psoriasiform pathology development in D6-deficient mice. Journal of Biological Chemistry, 288(51), pp. 36473-36483. (doi: 10.1074/jbc.M113.491563)

O'Carroll, C., Moloney, G., Hurley, G., Melgar, S., Brint, E., Nally, K., Nibbs, R.J. , Shanahan, F. and Carmody, R.J. (2013) Bcl-3 deficiency protects against dextran-sodium sulphate-induced colitis in the mouse. Clinical and Experimental Immunology, 173(2), pp. 332-342. (doi: 10.1111/cei.12119) (PMID:23607276)

Rot, A., McKimmie, C., Burt, C.L., Pallas, K.J., Jamieson, T., Pruenster, M., Horuk, R., Nibbs, R.J.B. and Graham, G.J. (2013) Cell-autonomous regulation of neutrophil migration by the D6 chemokine decoy receptor. Journal of Immunology, 190(12), pp. 6450-6456. (doi: 10.4049/jimmunol.1201429)

McKimmie, C.S. et al. (2013) An analysis of the function and expression of D6 on lymphatic endothelial cells. Blood, 121(18), pp. 3768-3777. (doi: 10.1182/blood-2012-04-425314)

Bunting, M.D., Comerford, I., Seach, N., Hammett, M. V., Asquith, D.L., Korner, H., Boyd, R. L., Nibbs, R.J.B. and McColl, S. R. (2013) CCX-CKR deficiency alters thymic stroma impairing thymocyte development and promoting autoimmunity. Blood, 121(1), pp. 118-128. (doi: 10.1182/blood-2012-06-434886)

Lee, K., Nibbs, R.J.B. and Graham, G.J. (2013) D6: the 'crowd controller’ at the immune gateway. Trends in Immunology, 34(1), pp. 7-12. (doi: 10.1016/j.it.2012.08.001)

Oleinika, K., Nibbs, R.J. , Graham, G.J. and Fraser, A.R. (2013) Suppression, subversion and escape: the role of regulatory T cells in cancer progression. Clinical and Experimental Immunology, 171(1), pp. 36-45. (doi: 10.1111/j.1365-2249.2012.04657.x)

Nibbs, R.J.B. and Graham, G.J. (2013) Immune regulation by atypical chemokine receptors. Nature Reviews Immunology, 13(11), pp. 815-829. (doi: 10.1038/nri3544)

Jamieson, T. et al. (2012) Inhibition of CXCR2 profoundly suppresses inflammation-driven and spontaneous tumorigenesis. Journal of Clinical Investigation, 122(9), pp. 3127-3144. (doi: 10.1172/JCI61067)

Menzies, F.M., Higgins, C.A., Shepherd, M.C., Nibbs, R.J.B. and Nelson, S.M. (2012) Mast cells reside in myometrium and cervix, but are dispensable in mice for successful pregnancy and labor. Immunology and Cell Biology, 90, pp. 321-329. (doi: 10.1038/icb.2011.40)

Menzies, F. M., Khan, A. H., Higgins, C. A., Nelson, S. M. and Nibbs, R. J. B. (2012) The chemokine receptor CCR2 is not required for successful initiation of labor in mice. Biology of Reproduction, 86(4), p. 118. (doi: 10.1095/biolreprod.111.094631)

Lee, K. M. et al. (2011) D6 facilitates cellular migration and fluid flow to lymph nodes by suppressing lymphatic congestion. Blood, 118(23), pp. 6220-6229. (doi: 10.1182/blood-2011-03-344044)

MacLellan, L. M., Montgomery, J., Sugiyama, F., Kitson, S. M., Thümmler, K. , Silverman, G. J., Beers, S. A., Nibbs, R. J.B. , McInnes, I. B. and Goodyear, C. S. (2011) Co-opting endogenous immunoglobulin for the regulation of inflammation and osteoclastogenesis in humans and mice. Arthritis and Rheumatism, 63(12), pp. 3897-3907. (doi: 10.1002/art.30629) (PMID:22127707) (PMCID:PMC3598489)

Hansell, C.A.H. and Nibbs, R.J.B. (2011) The odd couple: innate-like B cells and the chemokine scavenger D6. Cell Cycle, 10(21), pp. 3619-3620. (doi: 10.4161/cc.10.21.17851)

Hansell, C. A. H., Schiering, C., Kinstrie, R., Ford, L., Bordon, Y., McInnes, I. B. , Goodyear, C. S. and Nibbs, R. J.B. (2011) Universal expression and dual function of the atypical chemokine receptor D6 on innate-like B cells in mice. Blood, 117(20), pp. 5413-5424. (doi: 10.1182/blood-2010-11-317115) (PMID:21450903) (PMCID:PMC3188399)

Hansell, C.A.H., Hurson, C.E. and Nibbs, R.J.B. (2011) DARC and D6: silent partners in chemokine regulation? Immunology and Cell Biology, 89(2), pp. 197-206. (doi: 10.1038/icb.2010.147) (PMID:21151196) (PMCID:PMC3041651)

Menzies, F.M., Shepherd, M.C., Nibbs, R.J. and Nelson, S.M. (2011) The role of mast cells and their mediators in reproduction, pregnancy and labour. Human Reproduction Update, 17(3), pp. 383-396. (doi: 10.1093/humupd/dmq053)

Comerford, I., Nibbs, R. , Litchfield, W., Bunting, M., Harata-Lee, Y., Haylock-Jacobs, S., Forrow, S., Korner, H. and McColl, S.R. (2010) The atypical chemokine receptor CCX-CKR scavenges homeostatic chemokines in circulation and tissues and suppresses Th17 responses. Blood, 116(20), pp. 4130-4140. (doi: 10.1182/blood-2010-01-264390)

Leick, M., Catusse, J., Follo, M., Nibbs, R.J. , Hartmann, T.N., Veelken, H. and Burger, M. (2010) CCL19 is a specific ligand of the constitutively recycling atypical human chemokine receptor CRAM-B. Immunology, 129(4), pp. 536-546. (doi: 10.1111/j.1365-2567.2009.03209.x)

Henriques, C. M., Rino, J., Nibbs, R. J. , Graham, G. J. and Barata, J. T. (2010) IL-7 induces rapid clathrin-mediated internalization and JAK3-dependent degradation of IL-7R alpha in T cells. Blood, 115(16), pp. 3269-3277. (doi: 10.1182/blood-2009-10-246876)

Madigan, J. et al. (2010) Chemokine Scavenger D6 Is Expressed by Trophoblasts and Aids the Survival of Mouse Embryos Transferred into Allogeneic Recipients. Journal of Immunology, 184(6), pp. 3202-3212. (doi: 10.4049/jimmunol.0902118)

Menzies, F.M., Shepherd, M.C., Nibbs, R.J. and Nelson, S.M. (2010) The role of mast cells and their mediators in reproduction, pregnancy and labour. Human Reproduction Update, 17(3), pp. 383-396. (doi: 10.1093/humupd/dmq0532)

Nibbs, R.J. (2009) HIV: getting to the heart of DARCness. Blood, 114(13), p. 2783.

Alexander-Sefre, F., Nibbs, R.J. , Rafferty, T., Ayhan, A., Singh, N. and Jacobs, I. (2009) Clinical value of immunohistochemically detected lymphatic and vascular invasions in clinically staged endometrioid endometrial cancer. International Journal of Gynecological Cancer, 19(6), pp. 1074-1079. (doi: 10.1111/IGC.0b013e3181abb0c0)

McKimmie, C. S. et al. (2009) A TLR2 ligand suppresses inflammation by modulation of chemokine receptors and redirection of leukocyte migration. Blood, 113(18), pp. 4224-4231. (doi: 10.1182/blood-2008-08-174698) (PMID:19202130)

Bordon, Y., Hansell, C. A. H., Sester, D. P., Clarke, M. , Mowat, A. M. and Nibbs, R. J. B. (2009) The atypical chemokine receptor D6 contributes to the development of experimental colitis. Journal of Immunology, 182(8), pp. 5032-5040. (doi: 10.4049/jimmunol.0802802)

He, W. et al. (2009) Reply to: “Experimental aspects of copy number variant assays at CCL3L1”. Nature Medicine, 15(10), pp. 1117-1120. (doi: 10.1038/nm1009-1117)

Pruenster, M. et al. (2009) The Duffy antigen receptor for chemokines transports chemokines and supports their promigratory activity. Nature Immunology, 10(1), pp. 101-108. (doi: 10.1038/ni.1675)

McKimmie, C. S. et al. (2008) Hemopoietic cell expression of the chemokine decoy receptor D6 is dynamic and regulated by GATA1. Journal of Immunology, 181(5), pp. 3353-3363. (doi: 10.4049/jimmunol.181.11.8170-a) (PMID:19039854)

McCulloch, C., Morrow, V., Milasta, S., Comerford, I., Milligan, G. , Graham, G. , Isaacs, N. and Nibbs, R. (2008) Multiple roles for the C-terminal tail of the chemokine scavenger D6. Journal of Biological Chemistry, 283(12), pp. 7972-7982. (doi: 10.1074/jbc.M710128200)

Truman, L. et al. (2008) CX3CL1/fractalkine is released from apoptotic lymphocytes to stimulate macrophage chemotaxis. Blood, 112(13), pp. 5026-5036. (doi: 10.1182/blood-2008-06-162404)

Kosta, K., Sabroe, I., Göke, J., Nibbs, R. J.D. , Tsanakas, J., Whyte, M. K. and Teare, M. D. (2007) A Bayesian approach to copy-number-polymorphism analysis in nuclear pedigrees. American Journal of Human Genetics, 81(4), pp. 808-812. (doi: 10.1086/520096)

Nibbs, R. J.B. , Gilchrist, D. S., King, V., Ferra, A., Forrow, S., Hunter, K. D. and Graham, G. J. (2007) The atypical chemokine receptor D6 suppresses the development of chemically induced skin tumors. Journal of Clinical Investigation, 117(7), pp. 1884-1892. (doi: 10.1172/JCI30068)

Comerford, I., Harata-Lee, Y., Litchfield, W., Mccoll, S. and Nibbs, R. (2007) Regulation of chemotactic networks by 'atypical' receptors. BioEssays, 29, pp. 237-247. (doi: 10.1002/bies.20537)

Hansell, C. and Nibbs, R. (2007) Professional and Part-Time Chemokine Decoys in the Resolution of Inflammation. Science's Stke, 2007(384), e18. (doi: 10.1126/stke.3842007pe18)

Comerford, I., Milasta, S., Morrow, V., Milligan, G. and Nibbs, R. (2006) The chemokine receptor CCX-CKR mediates effective scavenging of CCL19 in vitro. European Journal of Immunology, 36(7), pp. 1904-1916. (doi: 10.1002/eji.200535716)

Cook, G., Harrison, S., Nibbs, R. and Prince, H. (2006) Immunotherapy of multiple myeloma: the start of a long and tortuous journey. Expert Review of Anticancer Therapy, 6, pp. 1769-1785. (doi: 10.1586/14737140.6.12.1769)

Hansell, C., Nibbs, R. and Simpson, C. (2006) Chernokine sequestration by atypical chemokine receptors. Biochemical Society Transactions, 34, pp. 1009-1013.

Kuroumalis, A., Nibbs, R. J. , Aptel, H., Wright, K. L., Kolios, G. and Ward, S. G. (2005) The chemokines CXCL9, CXCL10, and CXCL11 differentially stimulate G alpha(i)-independent signaling and actin responses in human intestinal myofibroblasts. Journal of Immunology, 175, pp. 5403-5411.

Comerford, L. and Nibbs, R. (2005) Post-translational control of chemokines: a role for,decoy receptors? Immunology Letters, 96, pp. 163-174. (doi: 10.1016/j.imlet.2004.08.018)

Gonzalez, E. et al. (2005) The influence of CCL3L1 gene-containing segmental duplications on HIV-1/AIDS susceptibility. Science, 307(5714), pp. 1434-1440.

Jamieson, T., Cook, D. N., Nibbs, R. J.B. , Rot, A., Nixon, C., Mclean, P., Alcami, A., Lira, S. A., Wiekowski, M. and Graham, G. J. (2005) The chemokine receptor D6 limits the inflammatory response in vivo. Nature Immunology, 6, pp. 403-411. (doi: 10.1038/ni1182)

Neil, S., Aasa-Chapman, M., Clapham, P., Nibbs, R. , McKnight, A. and Weiss, R. (2005) The promiscuous CC chemokine receptor D6 is a functional coreceptor for primary isolates of human immunodeficiency virus type 1 (HIV-1) and HIV-2 on astrocytes. Journal of Virology, 79, pp. 9618-9624. (doi: 10.1128/JVI.79.15.9618-9624.2005)

Weber, M., Blair, E., Simpson, C. V., O'Hara, M., Blackburn, P. E., Rot, A., Graham, G. J. and Nibbs, R. J.B. (2004) The chemokine receptor D6 constitutively traffics to and from the cell surface to internalize and degrade chemokine. Molecular Biology of the Cell, 15(5), pp. 2492-2508. (doi: 10.1091/mbc.E03-09-0634)

Blackburn, P. E., Simpson, C. V., Nibbs, R. J. B. , O'Hara, M., Booth, R., Poulos, J., Isaacs, N. W. and Graham, G. J. (2004) Purification and biochemical characterization of the D6 chemokine receptor. Biochemical Journal, 379(2), p. 263. (doi: 10.1042/BJ20031266)

Chvatchko, Y. et al. (2003) Inhibition of airway inflammation by amino-terminally modified RANTES/CC chemokine ligand 5 analogues is not mediated through CCR3. Journal of Immunology, 171(10), pp. 5498-5506.

Graham, G. and Nibbs, R. (2003) CCL27/PESKY: a novel paradigm for chemokine function. Expert Opinion on Biological Therapy, 3(1), pp. 15-22.

Nibbs, R. , Graham, G. and Rot, A. (2003) Chemokines on the move: control by the chemokine 'interceptors' Duffy blood group antigen and D6. Seminars in Immunology, 15(5), pp. 287-294.

Townson, J. R., Barcellos, L. F. and Nibbs, R. J.B. (2002) Gene copy number regulates the production of the human chemokine CCL3-L1. European Journal of Immunology, 32(10), pp. 3016-3026. (doi: 10.1002/1521-4141(2002010)32:10<3016::AID-IMMU3016>3.0.CO;2-D)

Gortz, A., Nibbs, R. J.B. , McLean, P., Jarmin, D., Lambie, W., Baird, J. W. and Graham, G. J. (2002) The chemokine ESkine/CCL27 displays novel modes of intracrine and paracrine function. Journal of Immunology, 169(3), pp. 1387-1394.

Townson, J. and Nibbs, R. (2002) Characterization of mouse CCX-CKR, a receptor for the lymphocyte-attracting chemokines TECK/mCCL25, SLC/mCCL21 and MIP-3 beta/mCCL19: comparison to human CCX-CKR. European Journal of Immunology, 32(5), pp. 1230-1241.

Nibbs, R. et al. (2001) The beta-chemokine receptor D6 is expressed by lymphatic endothelium and a subset of vascular tumors. American Journal of Pathology, 158, pp. 867-877.

Townson, J. R., Graham, G. J. , Landau, N. R., Rasala, B. and Nibbs, R. J.B. (2000) Aminooxypentane addition to the chemokine macrophage inflammatory Protein-1 alpha P increases receptor affinities and HIV inhibition. Journal of Biological Chemistry, 275(50), pp. 39254-39261. (doi: 10.1074/jbc.M006768200)

Nibbs, R. J.B. et al. (2000) C-C chemokine receptor 3 antagonism by the beta-chemokine macrophage inflammatory protein 4, a property strongly enhanced by an amino-terminal alanine-methionine swap. Journal of Immunology, 164(3), pp. 1488-97.

Book Sections

Ford, L. B., Hansell, C. A.H. and Nibbs, R. J.B. (2013) Using fluorescent chemokine uptake to detect chemokine receptors by fluorescent activated cell sorting. In: Cardona, A. E. and Ubogu, E. E. (eds.) Chemokines: Methods and Protocols. Series: Methods in Molecular Biology, 1013 (1013). Humana Press Inc.: New York, NY, pp. 203-214. ISBN 9781627034258 (doi: 10.1007/978-1-62703-426-5_13)

Singh, M., Nibbs, R.J. and Graham, G.J. (2010) The atypical chemokine receptors. In: Smit, M.J., Lira, S.A. and Leurs, R. (eds.) Chemokine Receptors as Drug Targets. Wiley-VCH: Weinheim, Germany. ISBN 9783527632008

Nibbs, R. J.B. , McLean, P., McCulloch, C., Riboldi‐Tunnicliffe, A., Blair, E., Zhu, Y., Isaacs, N. and Graham, G. J. (2009) Structure–function dissection of D6, an atypical scavenger receptor. In: Abelson, J. N. and Simon, M. I. (eds.) Chemokines, Part A. Series: Methods in enzymology (460). Academic Press: Amsterdam, pp. 245-261. ISBN 9780123749086 (doi: 10.1016/S0076-6879(09)05212-4)

Graham, G.J. and Nibbs, R.J. (2007) Chemokine receptors: a structural overview. In: Harrison, J.K. and Lukacs, N.W. (eds.) The Chemokine Receptors. Series: Receptors. Humana Press: Totowa, NJ, pp. 31-54. ISBN 978-1-58829-773-0

Conference or Workshop Item

Stapleton, G. , McIntyre, K. , Sherry, L. , Douce, G. , Milling, S. , Nibbs, R. , Latkovskis, I., Donald, C. and McDonnell, N. (2023) ‘I felt as if I was there’ - Can Virtual Reality (VR) Enhance Students’ Learning Experience of Immunology Teaching? AMEE Glasgow 2023, Glasgow, UK, 26-30 August 2023.

McIntyre, K. , Stapleton, G. , Sherry, L. , Donald, C. , Milling, S. , Nibbs, R. , Douce, G. , Latkovskis, I. and McDonnell, N. (2023) ‘I felt as if I was there’ - Can Virtual Reality (VR) Enhance Students’ Learning Experience of Immunology Teaching? 16th Annual University of Glasgow Learning and Teaching Conference, 29 Mar 2023. (Unpublished)

This list was generated on Tue Apr 23 04:31:36 2024 BST.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Placental chemokine compartmentalisation by atypical chemokine receptors.
    Medical Research Council
    2021 - 2026
     
  • Integrative Transport Phenomena in Chemokine Gradient Establishment
    Wellcome Trust
    2017 - 2023
     
  • Defining mechanisms that control T cell migration
    Medical Research Council
    2016 - 2019
     
  • The ACKR2-CCR2 axis in development and disease
    Medical Research Council
    2015 - 2020
     
  • Dissecting the function of Bcl-3 in NF-kappaB signaling in B cells
    Biotechnology and Biological Sciences Research Council
    2015 - 2018
     
  • Developing small molecule antagonists of the ACKR2 chemokine-scavenging receptor.
    Medical Research Council
    2014 - 2015
     
  • Regulation of intestinal Immune responses by the atypical Chemokine receptor CCRL1
    Medical Research Council
    2014 - 2017
     
  • The development of chemokines as novel clinical grade cell-sorting tools
    Chief Scientist Office
    2013 - 2015
     
  • Understanding and manipulating chemokines and their receptors in the context of adjuvants
    Biotechnology and Biological Sciences Research Council
    2011 - 2014
     
  • An investigation of the function of the atypical chemokine receptor D6 in trophoblasts
    Tenovus Scotland
    2011 - 2012
     
  • Improving Cellular Fitness for Therapy: the Novel Use of Chemokines as cell Sorting Agents
    Chief Scientist Office
    2011 - 2013
     
  • Regulation of the adaptive immune response by chemokine scavenging receptors
    Medical Research Council
    2010 - 2015
     
  • An investigation of the pro-tumorigenic activity of the chemokine receptor CXCR2 using models of de novo tumorigenesis.
    Medical Research Council
    2010 - 2012
     
  • Wellcome Trust VIP award
    Wellcome Trust
    2009 - 2009
     
  • Function of the chemokine receptor D6 on innate-like B cells
    Biotechnology and Biological Sciences Research Council
    2009 - 2012
     
  • The role of inflammation in the development and progression of oral cancer
    Tenovus Scotland
    2008 - 2009
     
  • Characterisation of the interaction of mast cells and myometrial smooth muscle in regulating parturition.
    Cunningham Trust
    2008 - 2010
     
  • Molecular mechanisms underpinning the anti-inflammatory activity of the D6 chemokine receptor
    Wellcome Trust
    2008 - 2011
     
  • Early pregnancy metabolic and inflammatory changes and their relationship to successful pregnancy
    Wellbeing of Women
    2007 - 2010
     
  • An investigation of the roles for leukocyte and lymphatic endothelial cell D6 in the orchestration of the in vivo inflammatory response
    Wellcome Trust
    2007 - 2010
     
  • Examining the impact of genetic variation in the chemokine network in multiple myeloma.
    British Society for Haematology
    2007 - 2008
     
  • Lymphangiogenesis in breast cancer
    West Research Endowment Funds
    2007 - 2009
     
  • An investigation of the in vivo function of the D6 chemokine decoy receptor
    Biotechnology and Biological Sciences Research Council
    2007 - 2010
     
  • The role of chemokine receptor in regulating intestinal inflammation
    Medical Research Council
    2007 - 2010
     
  • Pro-inflammatory chemokine function in de novo tumorigenesis
    Cancer Research UK
    2006 - 2009
     
  • Chemokine processing in rheumatoid arthritis
    Tenovus Scotland
    2006 - 2008
     
  • Function of the atypical chemokine receptor D6 in inflammation
    Arthritis Research UK
    2006 - 2009
     
  • The structure and function of the beta chemokine receptor D6 - a member of the family of G protein coupled receptors
    Biotechnology and Biological Sciences Research Council
    2006 - 2009
     
  • An investigation of the role of the chemokine receptor D6 in placental dysfunction
    Scottish Hospital Endowments Research Trust
    2005 - 2007
     
  • An investigation into the roles for RIN3 in normal haemopoiesis and leukaemia
    Leukaemia & Lymphoma Research
    2004 - 2007
     
  • Structural studies on the beta chemokine receptor D6
    Biotechnology and Biological Sciences Research Council
    2000 - 2006
     

Research datasets

Jump to: 2017
Number of items: 1.

2017

Onyiaodike, C. C., Murray, H., Zhang, Z., Meyer, B. J., Jordan, F., Brown, E. A., Nibbs, R. , Lyall, H., Sattar, N. , Nelson, S. and Freeman, D. (2017) Pre-conception maternal erythrocyte saturated to unsaturated fatty acid ratio predicts pregnancy after natural cycle frozen embryo transfer. [Data Collection]

This list was generated on Tue Apr 23 16:19:08 2024 BST.

Additional information

Invited International Presentations

  • 2012: Il Ciocco, Lucca, Italy - Gordon Conference "Chemotactic cytokines" - Session Chair
  • 2012: Dublin, Ireland - EACR/IACR Conference "The Tumour Microenvironment" - invited speaker
  • 2011: Montreal, Canada - Invited speaker at the University of Montreal
  • 2011: Konstanz, Germany - Invited speaker at the University of Konstanz
  • 2011: Glasgow, UK - Beatson International Cancer Conference "Cancer Models and Novel Therapeutics" - invited speaker
  • 2011: Montreal, Canada - 12th Annual Great Lakes GPCR Retreat - invited speaker
  • 2010: Liverpool, UK - National Cancer Research Institute Cancer Conference - invited speaker
  • 2010: Il Ciocco, Lucca, Italy - Gordon Conference "Chemotactic cytokines" - invited speaker
  • 2010: Glasgow, UK - West of Scotland School for Cancer Studies: "Skin cancer and melanoma: Bench to Clinic" - invited speaker
  • 2009: York, UK - Hull/York Medical School Symposium "Chemokine receptors in health and disease" - invited speaker
  • 2008: Lund, Sweden - Invited speaker at the University of Lund
  • 2008: Keystone, USA - Keystone symposium: "Chemokines and chemokine receptors" - Session Chair
  • 2007: Oslo, Norway - Invited speaker at the University of Oslo
  • 2007: Glasgow, UK - Beatson Institute workshop "Models of epithelial stem cells and cancer" - Session Chair
  • 2006: Belfast - Anglo-German Multiple Myeloma workshop - invited speaker
  • 2006: Glasgow - Bioscience2006 - invited speaker and session organiser
  • 2005: London, UK - Invited speaker at EuroSciCon meeting "Assaying chemokines and chemotaxis"
  • 2005: Harrogate - British Society of Immunology annual meeting - invited speaker