Dr Laura Medina-Ruiz
- Honorary Senior Lecturer (School of Infection & Immunity)
Publications
2025
Pingen, Marieke ORCID: https://orcid.org/0000-0001-5689-9076, Hughes, Catherine E.
ORCID: https://orcid.org/0000-0002-2152-0238, Medina-Ruiz, Laura, Mathie, Heather, Barrie, Jennifer A., Hansell, Chris A.H., Bartolini, Robin, Macleod, Megan K.L.
ORCID: https://orcid.org/0000-0003-1843-8580 and Graham, Gerard J.
ORCID: https://orcid.org/0000-0002-7801-204X
(2025)
Inflammatory chemokine receptors CCR1, CCR2, CCR3 and CCR5 are essential for an optimal T cell response to influenza.
Mucosal Immunology,
(Accepted for Publication)
2024
Medina-Ruiz, Laura, Bartolini, Robin ORCID: https://orcid.org/0000-0001-6875-6734, Mathie, Heather, Halawa, Heba A., Cunningham, Madeleine
ORCID: https://orcid.org/0000-0002-7545-6868 and Graham, Gerard
ORCID: https://orcid.org/0000-0002-7801-204X
(2024)
CCR1 and CCR2 coexpression on monocytes is nonredundant and delineates a distinct monocyte subpopulation.
Journal of Immunology,
(doi: 10.4049/jimmunol.2400007)
(PMID:38829123)
(PMCID:PMC11215633)
(Early Online Publication)
2023
Cuesta-Gomez, Nerea, Medina-Ruiz, Laura, Graham, Gerard J. ORCID: https://orcid.org/0000-0002-7801-204X and Campbell, John D.M.
(2023)
IL-6 and TGF-β-secreting adoptively-transferred murine mesenchymal stromal cells accelerate healing of psoriasis-like skin inflammation and upregulate IL-17A and TGF-β.
International Journal of Molecular Sciences, 24(12),
10132.
(doi: 10.3390/ijms241210132)
(PMID:37373278)
(PMCID:PMC10298958)
Gray, A. L. et al. (2023) Chemokine CXCL4 interactions with extracellular matrix proteoglycans mediate widespread immune cell recruitment independent of chemokine receptors. Cell Reports, 42(1), 111930. (doi: 10.1016/j.celrep.2022.111930) (PMID:36640356)
2022
Bartolini, Robin ORCID: https://orcid.org/0000-0001-6875-6734, Medina-Ruiz, Laura, Hayes, Alan J., Kelly, Christopher J., Halawa, Heba A. and Graham, Gerard J.
ORCID: https://orcid.org/0000-0002-7801-204X
(2022)
Inflammatory chemokine receptors support inflammatory macrophage and dendritic cell maturation.
ImmunoHorizons, 6(11),
pp. 743-759.
(doi: 10.4049/immunohorizons.2200069)
(PMID:36426967)
Medina-Ruiz, L. et al. (2022) Analysis of combinatorial chemokine receptor expression dynamics using multi-receptor reporter mice. eLife, 11, e72418. (doi: 10.7554/eLife.72418) (PMID:35699420) (PMCID:PMC9236609)
2021
Passman, A. M. et al. (2021) Maraviroc prevents HCC development by suppressing macrophages and the liver progenitor cell response in a murine chronic liver disease model. Cancers, 13(19), 4935. (doi: 10.3390/cancers13194935) (PMID:34638423) (PMCID:PMC8508380)
2020
Nosalski, R. et al. (2020) T cell-derived miRNA-214 mediates perivascular fibrosis in hypertension. Circulation Research, 126, pp. 988-1003. (doi: 10.1161/CIRCRESAHA.119.315428) (PMID:32065054) (PMCID:PMC7147427)
2019
Lee, Kit Ming, Wilson, Gillian J. ORCID: https://orcid.org/0000-0002-9513-8437, Pingen, Marieke
ORCID: https://orcid.org/0000-0001-5689-9076, Fukuoka, Ayumi
ORCID: https://orcid.org/0000-0002-6752-7814, Hansell, Christopher A.H., Bartolini, Robin, Medina-Ruiz, Laura and Graham, Gerard J.
ORCID: https://orcid.org/0000-0002-7801-204X
(2019)
Placental chemokine compartmentalisation: a novel mammalian molecular control mechanism.
PLoS Biology, 17(5),
e3000287.
(doi: 10.1371/journal.pbio.3000287)
(PMID:31141500)
(PMCID:PMC6557524)
Dyer, Douglas P. ORCID: https://orcid.org/0000-0001-5567-6241, Nebot, Joan Boix, Kelly, Christopher J., Medina-Ruiz, Laura, Schuette, Fabian and Graham, Gerard J.
ORCID: https://orcid.org/0000-0002-7801-204X
(2019)
The chemokine receptor CXCR2 contributes to murine adipocyte development.
Journal of Leukocyte Biology, 105(3),
pp. 497-506.
(doi: 10.1002/JLB.1A0618-216RR)
(PMID:30517976)
(PMCID:PMC6392114)
Dyer, D. P. et al. (2019) Chemokine receptor redundancy and specificity are context dependent. Immunity, 50(2), 378-389.e5. (doi: 10.1016/j.immuni.2019.01.009) (PMID:30784579) (PMCID:PMC6382461)
2018
Hansell, C. A.H. et al. (2018) The atypical chemokine receptor Ackr2 constrains NK cell migratory activity and promotes metastasis. Journal of Immunology, 201(8), pp. 2510-2519. (doi: 10.4049/jimmunol.1800131) (PMID:30158126) (PMCID:PMC6176105)
2017
Dyer, Douglas P. ORCID: https://orcid.org/0000-0001-5567-6241, Pallas, Kenneth, Medina Ruiz, Laura, Schuette, Fabian, Wilson, Gillian J.
ORCID: https://orcid.org/0000-0002-9513-8437 and Graham, Gerard J.
ORCID: https://orcid.org/0000-0002-7801-204X
(2017)
CXCR2 deficient mice display macrophage-dependent exaggerated acute inflammatory responses.
Scientific Reports, 7,
42681.
(doi: 10.1038/srep42681)
(PMID:28205614)
(PMCID:PMC5311995)
2011
Quesada, Víctor, Sarmiento-Mañús, Raquel, González-Bayón, Rebeca, Hricová, Andrea, Pérez-Marcos, Rubén, Graciá-Martínez, Eva, Medina-Ruiz, Laura, Leyva-Díaz, Eduardo, Ponce, Maria Rosa and Micol, José Luis (2011) Arabidopsis RUGOSA2 encodes an mTERF family member required for mitochondrion, chloroplast and leaf development. Plant Journal, 68(4), pp. 738-753. (doi: 10.1111/j.1365-313X.2011.04726.x) (PMID:21790815)
2010
Medina-Ruiz, Laura, Campoy, Susan, Latasa, Cristina, Cardenas, Paula, Alonso, Juan Carlos and Barbé, Jordi (2010) Overexpression of the recA gene decreases oral but not intraperitoneal fitness of Salmonella enterica. Infection and Immunity, 78(7), pp. 3217-3225. (doi: 10.1128/IAI.01321-09) (PMID:20457791) (PMCID:PMC2897385)
Articles
Pingen, Marieke ORCID: https://orcid.org/0000-0001-5689-9076, Hughes, Catherine E.
ORCID: https://orcid.org/0000-0002-2152-0238, Medina-Ruiz, Laura, Mathie, Heather, Barrie, Jennifer A., Hansell, Chris A.H., Bartolini, Robin, Macleod, Megan K.L.
ORCID: https://orcid.org/0000-0003-1843-8580 and Graham, Gerard J.
ORCID: https://orcid.org/0000-0002-7801-204X
(2025)
Inflammatory chemokine receptors CCR1, CCR2, CCR3 and CCR5 are essential for an optimal T cell response to influenza.
Mucosal Immunology,
(Accepted for Publication)
Medina-Ruiz, Laura, Bartolini, Robin ORCID: https://orcid.org/0000-0001-6875-6734, Mathie, Heather, Halawa, Heba A., Cunningham, Madeleine
ORCID: https://orcid.org/0000-0002-7545-6868 and Graham, Gerard
ORCID: https://orcid.org/0000-0002-7801-204X
(2024)
CCR1 and CCR2 coexpression on monocytes is nonredundant and delineates a distinct monocyte subpopulation.
Journal of Immunology,
(doi: 10.4049/jimmunol.2400007)
(PMID:38829123)
(PMCID:PMC11215633)
(Early Online Publication)
Cuesta-Gomez, Nerea, Medina-Ruiz, Laura, Graham, Gerard J. ORCID: https://orcid.org/0000-0002-7801-204X and Campbell, John D.M.
(2023)
IL-6 and TGF-β-secreting adoptively-transferred murine mesenchymal stromal cells accelerate healing of psoriasis-like skin inflammation and upregulate IL-17A and TGF-β.
International Journal of Molecular Sciences, 24(12),
10132.
(doi: 10.3390/ijms241210132)
(PMID:37373278)
(PMCID:PMC10298958)
Gray, A. L. et al. (2023) Chemokine CXCL4 interactions with extracellular matrix proteoglycans mediate widespread immune cell recruitment independent of chemokine receptors. Cell Reports, 42(1), 111930. (doi: 10.1016/j.celrep.2022.111930) (PMID:36640356)
Bartolini, Robin ORCID: https://orcid.org/0000-0001-6875-6734, Medina-Ruiz, Laura, Hayes, Alan J., Kelly, Christopher J., Halawa, Heba A. and Graham, Gerard J.
ORCID: https://orcid.org/0000-0002-7801-204X
(2022)
Inflammatory chemokine receptors support inflammatory macrophage and dendritic cell maturation.
ImmunoHorizons, 6(11),
pp. 743-759.
(doi: 10.4049/immunohorizons.2200069)
(PMID:36426967)
Medina-Ruiz, L. et al. (2022) Analysis of combinatorial chemokine receptor expression dynamics using multi-receptor reporter mice. eLife, 11, e72418. (doi: 10.7554/eLife.72418) (PMID:35699420) (PMCID:PMC9236609)
Passman, A. M. et al. (2021) Maraviroc prevents HCC development by suppressing macrophages and the liver progenitor cell response in a murine chronic liver disease model. Cancers, 13(19), 4935. (doi: 10.3390/cancers13194935) (PMID:34638423) (PMCID:PMC8508380)
Nosalski, R. et al. (2020) T cell-derived miRNA-214 mediates perivascular fibrosis in hypertension. Circulation Research, 126, pp. 988-1003. (doi: 10.1161/CIRCRESAHA.119.315428) (PMID:32065054) (PMCID:PMC7147427)
Lee, Kit Ming, Wilson, Gillian J. ORCID: https://orcid.org/0000-0002-9513-8437, Pingen, Marieke
ORCID: https://orcid.org/0000-0001-5689-9076, Fukuoka, Ayumi
ORCID: https://orcid.org/0000-0002-6752-7814, Hansell, Christopher A.H., Bartolini, Robin, Medina-Ruiz, Laura and Graham, Gerard J.
ORCID: https://orcid.org/0000-0002-7801-204X
(2019)
Placental chemokine compartmentalisation: a novel mammalian molecular control mechanism.
PLoS Biology, 17(5),
e3000287.
(doi: 10.1371/journal.pbio.3000287)
(PMID:31141500)
(PMCID:PMC6557524)
Dyer, Douglas P. ORCID: https://orcid.org/0000-0001-5567-6241, Nebot, Joan Boix, Kelly, Christopher J., Medina-Ruiz, Laura, Schuette, Fabian and Graham, Gerard J.
ORCID: https://orcid.org/0000-0002-7801-204X
(2019)
The chemokine receptor CXCR2 contributes to murine adipocyte development.
Journal of Leukocyte Biology, 105(3),
pp. 497-506.
(doi: 10.1002/JLB.1A0618-216RR)
(PMID:30517976)
(PMCID:PMC6392114)
Dyer, D. P. et al. (2019) Chemokine receptor redundancy and specificity are context dependent. Immunity, 50(2), 378-389.e5. (doi: 10.1016/j.immuni.2019.01.009) (PMID:30784579) (PMCID:PMC6382461)
Hansell, C. A.H. et al. (2018) The atypical chemokine receptor Ackr2 constrains NK cell migratory activity and promotes metastasis. Journal of Immunology, 201(8), pp. 2510-2519. (doi: 10.4049/jimmunol.1800131) (PMID:30158126) (PMCID:PMC6176105)
Dyer, Douglas P. ORCID: https://orcid.org/0000-0001-5567-6241, Pallas, Kenneth, Medina Ruiz, Laura, Schuette, Fabian, Wilson, Gillian J.
ORCID: https://orcid.org/0000-0002-9513-8437 and Graham, Gerard J.
ORCID: https://orcid.org/0000-0002-7801-204X
(2017)
CXCR2 deficient mice display macrophage-dependent exaggerated acute inflammatory responses.
Scientific Reports, 7,
42681.
(doi: 10.1038/srep42681)
(PMID:28205614)
(PMCID:PMC5311995)
Quesada, Víctor, Sarmiento-Mañús, Raquel, González-Bayón, Rebeca, Hricová, Andrea, Pérez-Marcos, Rubén, Graciá-Martínez, Eva, Medina-Ruiz, Laura, Leyva-Díaz, Eduardo, Ponce, Maria Rosa and Micol, José Luis (2011) Arabidopsis RUGOSA2 encodes an mTERF family member required for mitochondrion, chloroplast and leaf development. Plant Journal, 68(4), pp. 738-753. (doi: 10.1111/j.1365-313X.2011.04726.x) (PMID:21790815)
Medina-Ruiz, Laura, Campoy, Susan, Latasa, Cristina, Cardenas, Paula, Alonso, Juan Carlos and Barbé, Jordi (2010) Overexpression of the recA gene decreases oral but not intraperitoneal fitness of Salmonella enterica. Infection and Immunity, 78(7), pp. 3217-3225. (doi: 10.1128/IAI.01321-09) (PMID:20457791) (PMCID:PMC2897385)