Dr Julia Edgar

  • Senior Lecturer (Immunology)
  • Associate (School of Veterinary Medicine)

Research interests

I am interested in how disorders of the central nervous system myelin sheath affect axonal health and in particular, how the oligodendrocyte exerts axonal protection. Studies investigating the relationship between oligodendrocyte dysfunction and axonal pathology are undertaken in collaboration with the Nave lab at the Max Planck Institute of Experimental Medicine, in Göttingen, Germany. Our findings demonstrate that normal oligodendrocyte function is required for the long-term support of axonal integrity (Glia 57:1815-1824 and EMBO Mol Med 2:42-50). Although the mechanisms are still not fully understood, our data indicate that the oligodendrocyte modulates fast axonal transport (reviewd in Journal of Neuroscience 29:12776-12786) and a recent study led by the Nave lab raises the possibility that oligodendrocytes support axonal energy requirements (Nature 485Pages: 517–521). Our findings have implications for understanding axonal degeneration in neurodegenerative disorders such as multiple sclerosis and the leukodystrophies (reviewed in Current Opinion in Neurobiology 19 498-504).


 


Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Pro-inflammatory feedback loops in progressive multiple sclerosis: a role for the intrathecal antibody repertoire
    Multiple Sclerosis Society
    2016 - 2019
     
  • ZikaPLAN
    European Commission
    2016 - 2019
     
  • The role of the myelinic channel in axonal support
    Multiple Sclerosis Society
    2016 - 2019
     
  • response to MRC ZIKA call
    Medical Research Council
    2016 - 2017
     
  • Assocation studies with Guillain-Barre syndrome and neurotropism
    Medical Research Council
    2016 - 2017
     
  • A high throughput to identify small molecules
    Multiple Sclerosis Society
    2014 - 2015
     
  • Development of a in vitro screening system to minimise animal use in the search for factors that modulate (re)myelination
    National Centre for the Replacement of Animals Research
    2013 - 2014
     
  • An examination of demyelinated, dystrophic axons
    ELA Foundation
    2011 - 2012
     
  • An investigation of the role of microglia/macrophages in axonal damage, in the context of demyelination
    Multiple Sclerosis Society
    2009 - 2011
     
  • The development of an in vitro assay to test the consequences of the acute ablation of myelin proteins on axonal integrity.
    Multiple Sclerosis Society
    2008 - 2009
     
  • The mechanisms and markers of axonal damage in myelin abnormalities
    Multiple Sclerosis Society
    2005 - 2009
     

Teaching

  • BVMS Level 1
  • BSc Veterinary Biosciences Levels 1 and 3
  • BSc Neuroscience Levels 2, 3 and 4
  • BSc Immunology Level 3
  • MSc courses in ‘Brain Sciences’ and ‘Immunology and Inflammatory Disease’
  • Intercalated BSc Med Sci (Neuroscience)

 

Course/Programme Coordination

  • Post Graduate Taught Convenor for 3Is: 2016-present
  • Course coordinator Immunology Level 3A: 2015-present
  • Course coordinator MSc course in ‘in vitro and analytical techniques in neuroscience’: 2015-2018
  • Deputy Programme Director MSc programme in Infection Biology: 2015-16

Additional information

Grant Advisory Board

  • 2017 - present: Member, Multiple Sclerosis Society grant review panel 1

Invited International Presentations

  • 2018: Leipzig, Germany - Invited speaker, University of Leipzig Neurosciences Seminar series
  • 2017: Invited (by Biomed Central) Video Abstract of our manuscript ‘Zika virus tropism and interactions in myelinating neural cell cultures: CNS cells and myelin are preferentially affected’, Cumberworth et al., 2017 in Acta Neuropathologica Communications
  • 2016: Maine, USA - Invited oral presentation and session chair, 6th Molecular Mechanisms of Axonal Degeneration meeting
  • 2016: Il Ciocco, Italy - Invited co-discussant, Gordon Research Conference on Myelin
  • 2015: Obergurgl, Austria - Invited speaker, 5th Obergurgl Optic Nerve meeting
  • 2015: London, England, UK - Invited speaker, MS Frontiers
  • 2015: Edinburgh, Scotland, UK - Invited speaker, British Neuroscience Association Meeting
  • 2014: Edinburgh, Scotland, UK - Invited speaker Franco-Scottish seminar: Towards repair in multiple sclerosis
  • 2014: Edinburgh, Scotland, UK - Invited speaker, International Scientific Conference organised by The Myelin Project
  • 2013: Cancun, Mexico - Invited presentation, ISN/ASN Myelin Satellite Meeting
  • 2010: Portsmouth, England, UK - Invited speaker, Anatomical Society of Great Britain and Ireland
  • 2010: Liverpool, England, UK - Invited speaker, British Society for Immunology annual conference
  • 2009: Chicago, Illinois, USA - Invited speaker, Society for Neuroscience
  • 2008: Il Chioco, Italy - Invited speaker, Myelin Gordon Conference
  • 2007: Dead Sea, Israel - Invited speaker, MRI of Brain Connectivity and Microstructure
  • 2006: Cambridge, England, UK - Invited speaker, Molecular and Cellular Mechanisms of Axon Degeneration Meeting
  • 2005: Barcelona, Spain - Invited speaker, Euroconference on Intra-neuronal Transport and Communication

Prizes, Awards and Distinctions

  • 2018: Invited organizer (with M Coleman, Cambridge) 7th Molecular Mechanisms of Axonal Degeneration meeting
  • 2017: Invited local organising committee member, XIII European Meeting on Glial Cells in Health and Disease, Edinburgh
  • 2017: University of Glasgow, Scotland - Member of team awarded MVLS College Teaching Excellence Award
  • 2013: Göttingen, Germany - Associate Staff Scientist, Department of Neurogenetics, Max Planck Institute for Experimental Medicine
  • 1995: Wellcome Trust - Prize PhD Studentship, University of Edinburgh

Research Fellowship

  • 2011 - 2013: Göttingen, Germany - Department of Neurogenetics, Max Planck Institute for Experimental Medicine
  • 2005 - 2009: Multiple Sclerosis Society (Scotland) - Junior Fellowship

Publications

List by: Type | Date

Jump to: 2019 | 2018 | 2017 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2002 | 2001 | 2000
Number of items: 47.

2019

Bijland, S. et al. (2019) An in vitro model for studying CNS white matter: functional properties and experimental approaches. F1000Research, 8, 117. (doi:10.12688/f1000research.16802.1)

2018

Stassart, R. M., Möbius, W., Nave, K.-A. and Edgar, J. M. (2018) The axon-myelin unit in development and degenerative disease. Frontiers in Neuroscience, 12, 467. (doi:10.3389/fnins.2018.00467) (PMID:30050403) (PMCID:PMC6050401)

Konda, P. C. , Edgar, J. , Barnett, S. and Harvey, A. R. (2018) Minimally Invasive Microscopy Using GRIN Lens Microendoscopes. Biophotonics Congress: Biomedical Optics Congress 2018, Hollywood, FL, USA, 03-06 Apr 2018. BTh4C.4. ISBN 9781943580415 (doi:10.1364/BRAIN.2018.BTh4C.4)

2017

Bahey, N. G., Gadalla, K. K.E. , McGonigal, R., Bailey, M. E.S. , Edgar, J. M. and Cobb, S. R. (2017) Reduced axonal diameter of peripheral nerve fibres in a mouse model of Rett syndrome. Neuroscience, 358, pp. 261-268. (doi:10.1016/j.neuroscience.2017.06.061)

Cumberworth, S. L. et al. (2017) Zika virus tropism and interactions in myelinating neural cell cultures: CNS cells and myelin are preferentially affected. Acta Neuropathologica Communications, 5, 50. (doi:10.1186/s40478-017-0450-8) (PMID:28645311) (PMCID:PMC5481922)

Goebbels, S. et al. (2017) A neuronal PI(3,4,5)P3-dependent program of oligodendrocyte precursor recruitment and myelination. Nature Neuroscience, 20(1), pp. 10-15. (doi:10.1038/nn.4425) (PMID:27775720)

Berghoff, S. A. et al. (2017) Dietary cholesterol promotes repair of demyelinated lesions in the adult brain. Nature Communications, 8, 14241. (doi:10.1038/ncomms14241) (PMID:28117328) (PMCID:PMC5286209)

2015

Lindner, M. et al. (2015) Fibroblast growth factor signaling in multiple sclerosis: inhibition of myelination and induction of pro-inflammatory environment by FGF9 environment by Fibroblast Growth Factor 9. Brain, 2015(138), pp. 1875-1893. (doi:10.1093/brain/awv102) (PMID:25907862)

2014

Deighton, R. F., Le Bihan, T., Martin, S. F., Gerth, A. M. J., McCulloch, M., Edgar, J. M. , Kerr, L. E., Whittle, I. R. and McCulloch, J. (2014) Interactions among mitochondrial proteins altered in glioblastoma. Journal of Neuro-Oncology, 118(2), pp. 247-256. (doi:10.1007/s11060-014-1430-5)

Snaidero, N. et al. (2014) Myelin membrane wrapping of CNS axons by PI(3,4,5)P3-dependent polarized growth at the inner tongue. Cell, 156(1-2), pp. 277-290. (doi:10.1016/j.cell.2013.11.044)

Ioannidou, K., Anderson, K. I., Strachan, D., Edgar, J. M. and Barnett, S. C. (2014) Astroglial-axonal interactions during early stages of myelination in mixed cultures using in vitro and ex vivo imaging techniques. BMC Neuroscience, 15(1), p. 59. (doi:10.1186/1471-2202-15-59)

Yao, D. et al. (2014) Neuronal expression of galnac transferase is sufficient to prevent the age-related neurodegenerative phenotype of complex ganglioside-deficient mice. Journal of Neuroscience, 34(3), pp. 880-891. (doi:10.1523/JNEUROSCI.3996-13.2014)

2013

de Monasterio-Schrader, P., Patzig, J., Möbius, W., Barrette, B., Wagner, T.L., Kusch, K., Edgar, J.M. , Brophy, P.J. and Werner, H.B. (2013) Uncoupling of neuroinflammation from axonal degeneration in mice lacking the myelin protein tetraspanin-2. Glia, 61(11), pp. 1832-1847. (doi:10.1002/glia.22561)

Barrette, B., Nave, K.-A. and Edgar, J.M. (2013) Molecular triggers of neuroinflammation in mouse models of demyelinating diseases. Biological Chemistry, 394(12), (doi:10.1515/hsz-2013-0219)

2012

Franklin, R.J.M., ffrench-Constant, C., Edgar, J.M. and Smith, K.J. (2012) Neuroprotection and repair in multiple sclerosis. Nature Reviews Neurology, 8(11), pp. 624-634. (doi:10.1038/nrneurol.2012.200)

Gutierrez Quintana, R., Edgar, J. , Wessmann, A., Cherubini, G.B. and Penderis, J. (2012) The cutaneous trunci reflex for localising and grading thoracolumbar spinal cord injuries in dogs. Journal of Small Animal Practice, 53(8), pp. 470-475. (doi:10.1111/j.1748-5827.2012.01244.x) (PMID:22845846)

Funfschilling, U. et al. (2012) Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity. Nature, 485(7399), pp. 517-521. (doi:10.1038/nature11007)

Ioannidou, K., Anderson, K.I., Strachan, D., Edgar, J.M. and Barnett, S.C. (2012) Time-lapse imaging of the dynamics of CNS glial-axonal interactions in vitro and ex vivo. PLoS ONE, 7(1), e30775. (doi:10.1371/journal.pone.0030775)

Ip, C.W. et al. (2012) Neuroinflammation by cytotoxic T-lymphocytes impairs retrograde axonal transport in an oligodendrocyte mutant mouse. PLoS ONE, 7(8), e42554. (doi:10.1371/journal.pone.0042554) (PMID:22905147) (PMCID:PMC3414455)

2011

Ruest, T., Holmes, W.M. , Barrie, J.A., Griffiths, I.R., Anderson, T.J. , Dewar, D. and Edgar, J.M. (2011) High-resolution diffusion tensor imaging of fixed brain in a mouse model of Pelizaeus-Merzbacher disease: comparison with quantitative measures of white matter pathology. NMR in Biomedicine, 24(10), pp. 1369-1379. (doi:10.1002/nbm.1700)

Gruenenfelder, F.I., Thomson, G., Penderis, J. and Edgar, J.M. (2011) Axon-glial interaction in the CNS: what we have learned from mouse models of Pelizaeus-Merzbacher disease. Journal of Anatomy, 219(1), pp. 33-43. (doi:10.1111/j.1469-7580.2011.01363.x)

2010

Karim, S., Barrie, J., McCulloch, M., Montague, P., Edgar, J.M. , Iden, D.L., Anderson, T.J. , Nave, K.-A., Griffiths, I.R. and McLaughlin, M. (2010) PLP/DM20 expression and turnover in a transgenic mouse model of pelizaeus-merzbacher disease. Glia, 58(14), pp. 1727-1738. (doi:10.1002/glia.21043)

Edgar, J.M. , McCulloch, M.C., Montague, P., Brown, A., Thilemann, S., Pratola, L., Gruenenfelder, F.I., Griffiths, I. and Nave, K.A. (2010) Demyelination and axonal preservation in a transgenic mouse model of Pelizaeus-Merzbacher disease. EMBO Molecular Medicine, 2(2), pp. 42-50. (doi:10.1002/emmm.200900057)

2009

Hogan, V., White, K., Edgar, J. , McGill, A., Karim, S., McLaughlin, M. , Griffiths, I., Turnbull, D. and Nichols, P. (2009) Increase in mitochondrial density within axons and supporting cells in response to demyelination in the Plp1 mouse model. Journal of Neuroscience Research, 87(2), pp. 452-459. (doi:10.1002/jnr.21867)

Edgar, J. M. and Nave, K. A. (2009) The role of CNS glia in preserving axon function. Current Opinion in Neurobiology, 19(5), pp. 498-504. (doi:10.1016/j.conb.2009.08.003)

Edgar, J.M. , McLaughlin, M. , Werner, H.B., McCulloch, M.C., Barrie, J.A., Brown, A., Faichney, A., Snaidero, N., Nave, K.A. and Griffiths, I.R. (2009) Early Ultrastructural Defects of Axons and Axon-Glia Junctions in Mice Lacking Expression of Cnp1. Glia, 57(16), pp. 1815-1824. (doi:10.1002/glia.20893)

Morfini, G.A. et al. (2009) Axonal Transport Defects in Neurodegenerative Diseases. Journal of Neuroscience, 29(41), pp. 12776-12786. (doi:10.1523/JNEUROSCI.3463-09.2009 [Morfini, Gerardo A.; Burns, Matthew; Atagi, Yuka; Song, Yuyu; Pigino, Gustavo; Brady, Scott T.] Univ Illinois, Dept Anat & Cell Biol, Chicago, IL 60612 USA. [Binder, Lester I.; Kanaan, Nicholas M.; LaPointe, Nichole] No)

2008

Wang, E., Dimova, N., Sperle, K., Huang, Z., Lock, L., McCulloch, M., Edgar, J. , Hobson, G. and Cambi, F. (2008) Deletion of a splicing enhancer disrupts PLP1/DM20 ratio and myelin stability. Experimental Neurology, 214(2), pp. 322-330. (doi:10.1016/j.expneurol.2008.09.001)

Edgar, J.M. , McCulloch, M.C., Thomson, C.E. and Griffith, I.R. (2008) Distribution of mitochondria along small-diameter myelinated central nervous system axons. Journal of Neuroscience Research, 86(10), pp. 2250-2257. (doi:10.1002/jnr.21672)

2007

Edgar, J. (2007) Calcineurin differentially regulates fast myosin heavy chain genes in oxidative muscle fibre type conversion. Cell and Tissue Research, 329(3), pp. 515-527.

Karim, S.A., Barrie, J.A., McCulloch, M.C., Montague, M., Edgar, J.M. , Kirkham, D., Anderson, T.J. , Nave, K.A., Griffiths, I.R. and Mclaughlin, M. (2007) PLP overexpression perturbs myelin protein composition and myelination in a mouse model of Pelizaeus-Merzbacher disease. Glia, 55(4), pp. 341-351. (doi:10.1002/glia.20465)

McLaughlin, M., Karim, S., Montague, P., Barrie, J., Kirkham, D., Griffiths, I. and Edgar, J. (2007) Genetic background influences UPR but not PLP processing in the rumpshaker model of PMD/SPG2. Neurochemical Research, 32, pp. 167-176. (doi:10.1007/s11064-006-9122-y)

da Costa, N., Edgar, J. , Ooi, P., Su, Y., Meissner, J. and Chang, K. (2007) Calcineurin differentially regulates genes in oxidative muscle fibre type fast myosin heavy chain conversion. Cell and Tissue Research, 329, pp. 515-527. (doi:10.1007/s00441-007-0441-3)

2006

Ooi, P., da Costa, N., Edgar, J. and Chang, K. (2006) Porcine congenital splayleg is characterised by muscle fibre atrophy associated with relative rise in MAFbx and fall in P311 expression. BMC Veterinary Research, 2(1), p. 23. (doi:10.1186/1746-6148-2-23)

Andrews, H., White, K., Thomson, C., Edgar, J. , Bates, D., Griffiths, I., Turnbull, D. and Nichols, P. (2006) Increased axonal mitochondrial activity as an adaptation to myelin deficiency in the shiverer mouse. Journal of Neuroscience Research, 83, pp. 1533-1539. (doi:10.1002/jnr.20842)

Fowler, J., Edgar, J. , Pringle, A., McLaughlin, M., McCulloch, J., Griffiths, I., Garbern, J., Nave, K. and Dewar, D. (2006) alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid-mediated excitotoxic axonal damage is attenuated in the absence of myelin proteolipid protein. Journal of Neuroscience Research, 84, pp. 68-77. (doi:10.1002/jnr.20859)

McLaughlin, M., Barrie, J., Karim, S., Montague, P., Edgar, J. , Kirkham, D., Thomson, C. and Griffiths, I. (2006) Processing of PLP in a model of Pelizaeus-Merzbacher disease/SPG2 due to the rumpshaker mutation. Glia, 53, pp. 715-722. (doi:10.1002/glia.20325)

Thomson, C., Hunter, A., Griffiths, I., Edgar, J. and McCulloch, M. (2006) Murine spinal cord explants: A model for evaluating axonal growth and myelination in vitro. Journal of Neuroscience Research, 84, pp. 1703-1715. (doi:10.1002/jnr.21084)

2005

Montague, P., McCallion, A., Barrie, J., Edgar, J. , McLaughlin, M., Davies, R. and Griffiths, I. (2005) Characterization of the murine splice variant Mobp155: Developmental CNS expression pattern and subcellular localization of epitope-tagged protein. Glia, 50, pp. 80-85. (doi:10.1002/glia.20155)

2004

Edgar, J. et al. (2004) Oligodendroglial modulation of fast axonal transport in a mouse model of hereditary spastic paraplegia. Journal of Cell Biology, 166(1), pp. 121-131. (doi:10.1083/jcb.200312012) (PMID:15226307) (PMCID:PMC2172145)

Edgar, J. and Garbern, J. (2004) The myelinated axon is dependent on the myelinating cell for support and maintenance: Molecules involved. Journal of Neuroscience Research, 76(5), pp. 593-598. (doi:10.1002/jnr.20063)

Edgar, J. , McLaughlin, M., Barrie, J., McCulloch, M., Garbern, J. and Griffiths, I. (2004) Age-related axonal and myelin changes in the rumpshaker mutation of the Plp gene. Acta Neuropathologica, 107, pp. 331-335. (doi:10.1007/s00401-003-0808-9)

2002

Yool, D. , Montague, P., McLaughlin, M., McCulloch, M., Edgar, J., Nave, K., Davies, R., Griffiths, I. and McCallion, A. (2002) Phenotypic analysis of mice deficient in the major myelin protein MOBP, and evidence for a novel Mobp isoform. Glia, 39(3), pp. 256-267. (doi:10.1002/glia.10103) (PMID:12203392)

Edgar, J.M. , Anderson, T.J. , Dickinson, P.J., Barrie, J.A., McCulloch, M.C., Nave, K.A. and Griffiths, I.R. (2002) Survival of, and competition between, oligodendrocytes expressing different alleles of the Plp gene. Journal of Cell Biology, 158, pp. 719-729. (doi:10.1083/jcb.200202124)

2001

Edgar, J. (2001) Radial migration in the cerebral cortex is enhanced by signals from thalamus. European Journal of Neuroscience, 13(9), pp. 1745-1754.

Edgar, J. (2001) The fates of cells generated at the end of neurogenesis in developing mouse cortex. Journal of Neurobiology, 48(4), pp. 265-277.

2000

Yool, D. A. , Edgar, J. M. , Montague, P. and Malcolm, S. (2000) The proteolipid protein gene and myelin disorders in man and animal models. Human Molecular Genetics, 9(6), pp. 987-992. (doi:10.1093/hmg/9.6.987) (PMID:10767322)

This list was generated on Tue Apr 23 10:32:59 2019 BST.
Number of items: 47.

Articles

Bijland, S. et al. (2019) An in vitro model for studying CNS white matter: functional properties and experimental approaches. F1000Research, 8, 117. (doi:10.12688/f1000research.16802.1)

Stassart, R. M., Möbius, W., Nave, K.-A. and Edgar, J. M. (2018) The axon-myelin unit in development and degenerative disease. Frontiers in Neuroscience, 12, 467. (doi:10.3389/fnins.2018.00467) (PMID:30050403) (PMCID:PMC6050401)

Bahey, N. G., Gadalla, K. K.E. , McGonigal, R., Bailey, M. E.S. , Edgar, J. M. and Cobb, S. R. (2017) Reduced axonal diameter of peripheral nerve fibres in a mouse model of Rett syndrome. Neuroscience, 358, pp. 261-268. (doi:10.1016/j.neuroscience.2017.06.061)

Cumberworth, S. L. et al. (2017) Zika virus tropism and interactions in myelinating neural cell cultures: CNS cells and myelin are preferentially affected. Acta Neuropathologica Communications, 5, 50. (doi:10.1186/s40478-017-0450-8) (PMID:28645311) (PMCID:PMC5481922)

Goebbels, S. et al. (2017) A neuronal PI(3,4,5)P3-dependent program of oligodendrocyte precursor recruitment and myelination. Nature Neuroscience, 20(1), pp. 10-15. (doi:10.1038/nn.4425) (PMID:27775720)

Berghoff, S. A. et al. (2017) Dietary cholesterol promotes repair of demyelinated lesions in the adult brain. Nature Communications, 8, 14241. (doi:10.1038/ncomms14241) (PMID:28117328) (PMCID:PMC5286209)

Lindner, M. et al. (2015) Fibroblast growth factor signaling in multiple sclerosis: inhibition of myelination and induction of pro-inflammatory environment by FGF9 environment by Fibroblast Growth Factor 9. Brain, 2015(138), pp. 1875-1893. (doi:10.1093/brain/awv102) (PMID:25907862)

Deighton, R. F., Le Bihan, T., Martin, S. F., Gerth, A. M. J., McCulloch, M., Edgar, J. M. , Kerr, L. E., Whittle, I. R. and McCulloch, J. (2014) Interactions among mitochondrial proteins altered in glioblastoma. Journal of Neuro-Oncology, 118(2), pp. 247-256. (doi:10.1007/s11060-014-1430-5)

Snaidero, N. et al. (2014) Myelin membrane wrapping of CNS axons by PI(3,4,5)P3-dependent polarized growth at the inner tongue. Cell, 156(1-2), pp. 277-290. (doi:10.1016/j.cell.2013.11.044)

Ioannidou, K., Anderson, K. I., Strachan, D., Edgar, J. M. and Barnett, S. C. (2014) Astroglial-axonal interactions during early stages of myelination in mixed cultures using in vitro and ex vivo imaging techniques. BMC Neuroscience, 15(1), p. 59. (doi:10.1186/1471-2202-15-59)

Yao, D. et al. (2014) Neuronal expression of galnac transferase is sufficient to prevent the age-related neurodegenerative phenotype of complex ganglioside-deficient mice. Journal of Neuroscience, 34(3), pp. 880-891. (doi:10.1523/JNEUROSCI.3996-13.2014)

de Monasterio-Schrader, P., Patzig, J., Möbius, W., Barrette, B., Wagner, T.L., Kusch, K., Edgar, J.M. , Brophy, P.J. and Werner, H.B. (2013) Uncoupling of neuroinflammation from axonal degeneration in mice lacking the myelin protein tetraspanin-2. Glia, 61(11), pp. 1832-1847. (doi:10.1002/glia.22561)

Barrette, B., Nave, K.-A. and Edgar, J.M. (2013) Molecular triggers of neuroinflammation in mouse models of demyelinating diseases. Biological Chemistry, 394(12), (doi:10.1515/hsz-2013-0219)

Franklin, R.J.M., ffrench-Constant, C., Edgar, J.M. and Smith, K.J. (2012) Neuroprotection and repair in multiple sclerosis. Nature Reviews Neurology, 8(11), pp. 624-634. (doi:10.1038/nrneurol.2012.200)

Gutierrez Quintana, R., Edgar, J. , Wessmann, A., Cherubini, G.B. and Penderis, J. (2012) The cutaneous trunci reflex for localising and grading thoracolumbar spinal cord injuries in dogs. Journal of Small Animal Practice, 53(8), pp. 470-475. (doi:10.1111/j.1748-5827.2012.01244.x) (PMID:22845846)

Funfschilling, U. et al. (2012) Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity. Nature, 485(7399), pp. 517-521. (doi:10.1038/nature11007)

Ioannidou, K., Anderson, K.I., Strachan, D., Edgar, J.M. and Barnett, S.C. (2012) Time-lapse imaging of the dynamics of CNS glial-axonal interactions in vitro and ex vivo. PLoS ONE, 7(1), e30775. (doi:10.1371/journal.pone.0030775)

Ip, C.W. et al. (2012) Neuroinflammation by cytotoxic T-lymphocytes impairs retrograde axonal transport in an oligodendrocyte mutant mouse. PLoS ONE, 7(8), e42554. (doi:10.1371/journal.pone.0042554) (PMID:22905147) (PMCID:PMC3414455)

Ruest, T., Holmes, W.M. , Barrie, J.A., Griffiths, I.R., Anderson, T.J. , Dewar, D. and Edgar, J.M. (2011) High-resolution diffusion tensor imaging of fixed brain in a mouse model of Pelizaeus-Merzbacher disease: comparison with quantitative measures of white matter pathology. NMR in Biomedicine, 24(10), pp. 1369-1379. (doi:10.1002/nbm.1700)

Gruenenfelder, F.I., Thomson, G., Penderis, J. and Edgar, J.M. (2011) Axon-glial interaction in the CNS: what we have learned from mouse models of Pelizaeus-Merzbacher disease. Journal of Anatomy, 219(1), pp. 33-43. (doi:10.1111/j.1469-7580.2011.01363.x)

Karim, S., Barrie, J., McCulloch, M., Montague, P., Edgar, J.M. , Iden, D.L., Anderson, T.J. , Nave, K.-A., Griffiths, I.R. and McLaughlin, M. (2010) PLP/DM20 expression and turnover in a transgenic mouse model of pelizaeus-merzbacher disease. Glia, 58(14), pp. 1727-1738. (doi:10.1002/glia.21043)

Edgar, J.M. , McCulloch, M.C., Montague, P., Brown, A., Thilemann, S., Pratola, L., Gruenenfelder, F.I., Griffiths, I. and Nave, K.A. (2010) Demyelination and axonal preservation in a transgenic mouse model of Pelizaeus-Merzbacher disease. EMBO Molecular Medicine, 2(2), pp. 42-50. (doi:10.1002/emmm.200900057)

Hogan, V., White, K., Edgar, J. , McGill, A., Karim, S., McLaughlin, M. , Griffiths, I., Turnbull, D. and Nichols, P. (2009) Increase in mitochondrial density within axons and supporting cells in response to demyelination in the Plp1 mouse model. Journal of Neuroscience Research, 87(2), pp. 452-459. (doi:10.1002/jnr.21867)

Edgar, J. M. and Nave, K. A. (2009) The role of CNS glia in preserving axon function. Current Opinion in Neurobiology, 19(5), pp. 498-504. (doi:10.1016/j.conb.2009.08.003)

Edgar, J.M. , McLaughlin, M. , Werner, H.B., McCulloch, M.C., Barrie, J.A., Brown, A., Faichney, A., Snaidero, N., Nave, K.A. and Griffiths, I.R. (2009) Early Ultrastructural Defects of Axons and Axon-Glia Junctions in Mice Lacking Expression of Cnp1. Glia, 57(16), pp. 1815-1824. (doi:10.1002/glia.20893)

Morfini, G.A. et al. (2009) Axonal Transport Defects in Neurodegenerative Diseases. Journal of Neuroscience, 29(41), pp. 12776-12786. (doi:10.1523/JNEUROSCI.3463-09.2009 [Morfini, Gerardo A.; Burns, Matthew; Atagi, Yuka; Song, Yuyu; Pigino, Gustavo; Brady, Scott T.] Univ Illinois, Dept Anat & Cell Biol, Chicago, IL 60612 USA. [Binder, Lester I.; Kanaan, Nicholas M.; LaPointe, Nichole] No)

Wang, E., Dimova, N., Sperle, K., Huang, Z., Lock, L., McCulloch, M., Edgar, J. , Hobson, G. and Cambi, F. (2008) Deletion of a splicing enhancer disrupts PLP1/DM20 ratio and myelin stability. Experimental Neurology, 214(2), pp. 322-330. (doi:10.1016/j.expneurol.2008.09.001)

Edgar, J.M. , McCulloch, M.C., Thomson, C.E. and Griffith, I.R. (2008) Distribution of mitochondria along small-diameter myelinated central nervous system axons. Journal of Neuroscience Research, 86(10), pp. 2250-2257. (doi:10.1002/jnr.21672)

Edgar, J. (2007) Calcineurin differentially regulates fast myosin heavy chain genes in oxidative muscle fibre type conversion. Cell and Tissue Research, 329(3), pp. 515-527.

Karim, S.A., Barrie, J.A., McCulloch, M.C., Montague, M., Edgar, J.M. , Kirkham, D., Anderson, T.J. , Nave, K.A., Griffiths, I.R. and Mclaughlin, M. (2007) PLP overexpression perturbs myelin protein composition and myelination in a mouse model of Pelizaeus-Merzbacher disease. Glia, 55(4), pp. 341-351. (doi:10.1002/glia.20465)

McLaughlin, M., Karim, S., Montague, P., Barrie, J., Kirkham, D., Griffiths, I. and Edgar, J. (2007) Genetic background influences UPR but not PLP processing in the rumpshaker model of PMD/SPG2. Neurochemical Research, 32, pp. 167-176. (doi:10.1007/s11064-006-9122-y)

da Costa, N., Edgar, J. , Ooi, P., Su, Y., Meissner, J. and Chang, K. (2007) Calcineurin differentially regulates genes in oxidative muscle fibre type fast myosin heavy chain conversion. Cell and Tissue Research, 329, pp. 515-527. (doi:10.1007/s00441-007-0441-3)

Ooi, P., da Costa, N., Edgar, J. and Chang, K. (2006) Porcine congenital splayleg is characterised by muscle fibre atrophy associated with relative rise in MAFbx and fall in P311 expression. BMC Veterinary Research, 2(1), p. 23. (doi:10.1186/1746-6148-2-23)

Andrews, H., White, K., Thomson, C., Edgar, J. , Bates, D., Griffiths, I., Turnbull, D. and Nichols, P. (2006) Increased axonal mitochondrial activity as an adaptation to myelin deficiency in the shiverer mouse. Journal of Neuroscience Research, 83, pp. 1533-1539. (doi:10.1002/jnr.20842)

Fowler, J., Edgar, J. , Pringle, A., McLaughlin, M., McCulloch, J., Griffiths, I., Garbern, J., Nave, K. and Dewar, D. (2006) alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid-mediated excitotoxic axonal damage is attenuated in the absence of myelin proteolipid protein. Journal of Neuroscience Research, 84, pp. 68-77. (doi:10.1002/jnr.20859)

McLaughlin, M., Barrie, J., Karim, S., Montague, P., Edgar, J. , Kirkham, D., Thomson, C. and Griffiths, I. (2006) Processing of PLP in a model of Pelizaeus-Merzbacher disease/SPG2 due to the rumpshaker mutation. Glia, 53, pp. 715-722. (doi:10.1002/glia.20325)

Thomson, C., Hunter, A., Griffiths, I., Edgar, J. and McCulloch, M. (2006) Murine spinal cord explants: A model for evaluating axonal growth and myelination in vitro. Journal of Neuroscience Research, 84, pp. 1703-1715. (doi:10.1002/jnr.21084)

Montague, P., McCallion, A., Barrie, J., Edgar, J. , McLaughlin, M., Davies, R. and Griffiths, I. (2005) Characterization of the murine splice variant Mobp155: Developmental CNS expression pattern and subcellular localization of epitope-tagged protein. Glia, 50, pp. 80-85. (doi:10.1002/glia.20155)

Edgar, J. et al. (2004) Oligodendroglial modulation of fast axonal transport in a mouse model of hereditary spastic paraplegia. Journal of Cell Biology, 166(1), pp. 121-131. (doi:10.1083/jcb.200312012) (PMID:15226307) (PMCID:PMC2172145)

Edgar, J. and Garbern, J. (2004) The myelinated axon is dependent on the myelinating cell for support and maintenance: Molecules involved. Journal of Neuroscience Research, 76(5), pp. 593-598. (doi:10.1002/jnr.20063)

Edgar, J. , McLaughlin, M., Barrie, J., McCulloch, M., Garbern, J. and Griffiths, I. (2004) Age-related axonal and myelin changes in the rumpshaker mutation of the Plp gene. Acta Neuropathologica, 107, pp. 331-335. (doi:10.1007/s00401-003-0808-9)

Yool, D. , Montague, P., McLaughlin, M., McCulloch, M., Edgar, J., Nave, K., Davies, R., Griffiths, I. and McCallion, A. (2002) Phenotypic analysis of mice deficient in the major myelin protein MOBP, and evidence for a novel Mobp isoform. Glia, 39(3), pp. 256-267. (doi:10.1002/glia.10103) (PMID:12203392)

Edgar, J.M. , Anderson, T.J. , Dickinson, P.J., Barrie, J.A., McCulloch, M.C., Nave, K.A. and Griffiths, I.R. (2002) Survival of, and competition between, oligodendrocytes expressing different alleles of the Plp gene. Journal of Cell Biology, 158, pp. 719-729. (doi:10.1083/jcb.200202124)

Edgar, J. (2001) Radial migration in the cerebral cortex is enhanced by signals from thalamus. European Journal of Neuroscience, 13(9), pp. 1745-1754.

Edgar, J. (2001) The fates of cells generated at the end of neurogenesis in developing mouse cortex. Journal of Neurobiology, 48(4), pp. 265-277.

Yool, D. A. , Edgar, J. M. , Montague, P. and Malcolm, S. (2000) The proteolipid protein gene and myelin disorders in man and animal models. Human Molecular Genetics, 9(6), pp. 987-992. (doi:10.1093/hmg/9.6.987) (PMID:10767322)

Conference or Workshop Item

Konda, P. C. , Edgar, J. , Barnett, S. and Harvey, A. R. (2018) Minimally Invasive Microscopy Using GRIN Lens Microendoscopes. Biophotonics Congress: Biomedical Optics Congress 2018, Hollywood, FL, USA, 03-06 Apr 2018. BTh4C.4. ISBN 9781943580415 (doi:10.1364/BRAIN.2018.BTh4C.4)

This list was generated on Tue Apr 23 10:32:59 2019 BST.