Dr Gavin Meehan

  • Research Associate (Immunology)

Biography

I received a MSci (hons) degree in pharmacology from the University of Glasgow in 2011. As part of this degree I undertook research in the life sciences industry, working for both a local biotech company, Biofilm, and the pharmaceutical company, Pfizer. Upon completion of my undergraduate degree, I began a Ph.D., studying the roles of anti-glycolipid antibodies in autoimmune neuropathies, with Prof. Hugh Willison at the University of Glasgow.

After my Ph.D. I began my postdoctoral research at the University of Glasgow in the Laboratory of Immune Cell Visualisation and Examination (LIVE) under Profs James Brewer and Paul Garside. My research in this laboratory has focussed on the roles of the immune system during autoimmune diseases and infections with a particular focus on studying the dynamics of these processes using multiphoton microscopy.  

Research interests

I first developed an interest in the role of the immune system in autoimmune diseases during my Ph.D. where I created a series of anti-glycolipid antibodies for studying paralytic autoimmune neuropathies. Following on from my PhD, I was keen to expand my knowledge of immunology further and decided to join the Laboratory of Immune Cell Visualisation and Examination (LIVE). As part of LIVE, I was able to study various other autoimmune diseases including scleroderma and rheumatoid arthritis as well as infective diseases including malaria.

This research has involved the use of a number of techniques including multiparameter flow cytometry, cell-based assays, whole body imaging and multiphoton microscopy. One technique in which I am particularly interested is intravital imaging, which I use for studying the temporal and dynamic behaviours of immune cells in disease. Several of my projects have involved the use and development of mouse models for this purpose, allowing for the tracking and visualisation of both host and parasite interactions and responses in real time. This has allowed me to study these cells in a manner that is not possible with other methods and has proven useful for fostering collaborations with other researchers both within the University and across the UK.

Publications

List by: Type | Date

Jump to: 2020 | 2019 | 2018 | 2016 | 2015 | 2014 | 2013
Number of items: 13.

2020

Cunningham, M. E. , Meehan, G. R. , Robinson, S., Yao, D., McGonigal, R. and Willison, H. J. (2020) Perisynaptic Schwann cells phagocytose nerve terminal debris in a mouse model of Guillain-Barré syndrome. Journal of the Peripheral Nervous System, 25(2), pp. 143-151. (doi: 10.1111/jns.12373) (PMID:32250537)

Meehan, G. R. , Scales, H. E. , Osii, R., De Niz, M., Lawton, J. C., Marti, M. , Garside, P. , Craig, A. and Brewer, J. M. (2020) Developing a xenograft model of human vasculature in the mouse ear pinna. Scientific Reports, 10, 2058. (doi: 10.1038/s41598-020-58650-y) (PMID:32029768) (PMCID:PMC7004987)

2019

De Niz, M., Meehan, G. R. and Tavares, J. (2019) Intravital microscopy: imaging host‐parasite interactions in lymphoid organs. Cellular Microbiology, 21(12), e13117. (doi: 10.1111/cmi.13117) (PMID:31512335)

De Niz, M., Meehan, G. R. , Brancucci, N. M.B. , Marti, M. , Rotureau, B., Figueiredo, L. M. and Frischknecht, F. (2019) Intravital imaging of host-parasite interactions in skin and adipose tissues. Cellular Microbiology, 21(5), e13023. (doi: 10.1111/cmi.13023) (PMID:30825872)

Hayes, A. J. et al. (2019) Spatiotemporal modeling of the key migratory events during the initiation of adaptive immunity. Frontiers in Immunology, 10, 598. (doi: 10.3389/fimmu.2019.00598) (PMID:31024523) (PMCID:PMC6460458)

2018

Scales, H. E. et al. (2018) A novel cellular pathway of antigen presentation and CD4 T cell activation in vivo. Frontiers in Immunology, 9, 2684. (doi: 10.3389/fimmu.2018.02684)

Meehan, G. R. , McGonigal, R., Cunningham, M. E. , Wang, Y., Barrie, J. A., Halstead, S. K., Gourlay, D., Yao, D. and Willison, H. J. (2018) Differential binding patterns of anti-sulfatide antibodies to glial membranes. Journal of Neuroimmunology, 323, pp. 28-35. (doi: 10.1016/j.jneuroim.2018.07.004) (PMID:30196830) (PMCID:PMC6134133)

Noonan, J. et al. (2018) In vivo multiplex molecular imaging of vascular inflammation using surface-enhanced Raman spectroscopy. Theranostics, 8(22), pp. 6195-6209. (doi: 10.7150/thno.28665) (PMID:30613292) (PMCID:PMC6299693)

2016

Cunningham, M. , McGonigal, R., Meehan, G. R. , Barrie, J. A., Yao, D., Halstead, S. K. and Willison, H. J. (2016) Anti-ganglioside antibodies are removed from circulation in mice by neuronal endocytosis. Brain, 139(6), pp. 1657-1665. (doi: 10.1093/brain/aww056) (PMID:27017187) (PMCID:PMC4892750)

Meehan, G. (2016) Glycolipids in GBS: from basic science to clinical interface. In: Willison, H. J. and Goodfellow, J. (eds.) GBS100: Celebrating a Century of Progress in Guillain-Barré Syndrome. Peripheral Nerve Society: San Diego, CA, pp. 327-333. ISBN 9780997510300

2015

Delmont, E., Robb, H., Davidson, A., Halstead, S., Yao, D., Meehan, G. R. and Willison, H. (2015) Prospective study comparing enzyme-linked immunosorbent assay and glycoarray assay to detect antiglycolipid antibodies in a routine diagnostic neuroimmunology laboratory setting. Clinical and Experimental Neuroimmunology, 6(2), pp. 175-182. (doi: 10.1111/cen3.12193)

2014

Yao, D. et al. (2014) Neuronal expression of galnac transferase is sufficient to prevent the age-related neurodegenerative phenotype of complex ganglioside-deficient mice. Journal of Neuroscience, 34(3), pp. 880-891. (doi: 10.1523/JNEUROSCI.3996-13.2014)

2013

Rupp, A., Yao, D., Meehan, G. R. and Willison, H. J. (2013) Thy-1 Mice Lend Themselves for the Modelling of Anti-ganglioside Antibody-mediated Disorders. PNS Biennial Meeting of the Peripheral Nerve Society, St Malo, France, 11-14 Jun 2013.

This list was generated on Mon Oct 19 01:08:52 2020 BST.
Number of items: 13.

Articles

Cunningham, M. E. , Meehan, G. R. , Robinson, S., Yao, D., McGonigal, R. and Willison, H. J. (2020) Perisynaptic Schwann cells phagocytose nerve terminal debris in a mouse model of Guillain-Barré syndrome. Journal of the Peripheral Nervous System, 25(2), pp. 143-151. (doi: 10.1111/jns.12373) (PMID:32250537)

Meehan, G. R. , Scales, H. E. , Osii, R., De Niz, M., Lawton, J. C., Marti, M. , Garside, P. , Craig, A. and Brewer, J. M. (2020) Developing a xenograft model of human vasculature in the mouse ear pinna. Scientific Reports, 10, 2058. (doi: 10.1038/s41598-020-58650-y) (PMID:32029768) (PMCID:PMC7004987)

De Niz, M., Meehan, G. R. and Tavares, J. (2019) Intravital microscopy: imaging host‐parasite interactions in lymphoid organs. Cellular Microbiology, 21(12), e13117. (doi: 10.1111/cmi.13117) (PMID:31512335)

De Niz, M., Meehan, G. R. , Brancucci, N. M.B. , Marti, M. , Rotureau, B., Figueiredo, L. M. and Frischknecht, F. (2019) Intravital imaging of host-parasite interactions in skin and adipose tissues. Cellular Microbiology, 21(5), e13023. (doi: 10.1111/cmi.13023) (PMID:30825872)

Hayes, A. J. et al. (2019) Spatiotemporal modeling of the key migratory events during the initiation of adaptive immunity. Frontiers in Immunology, 10, 598. (doi: 10.3389/fimmu.2019.00598) (PMID:31024523) (PMCID:PMC6460458)

Scales, H. E. et al. (2018) A novel cellular pathway of antigen presentation and CD4 T cell activation in vivo. Frontiers in Immunology, 9, 2684. (doi: 10.3389/fimmu.2018.02684)

Meehan, G. R. , McGonigal, R., Cunningham, M. E. , Wang, Y., Barrie, J. A., Halstead, S. K., Gourlay, D., Yao, D. and Willison, H. J. (2018) Differential binding patterns of anti-sulfatide antibodies to glial membranes. Journal of Neuroimmunology, 323, pp. 28-35. (doi: 10.1016/j.jneuroim.2018.07.004) (PMID:30196830) (PMCID:PMC6134133)

Noonan, J. et al. (2018) In vivo multiplex molecular imaging of vascular inflammation using surface-enhanced Raman spectroscopy. Theranostics, 8(22), pp. 6195-6209. (doi: 10.7150/thno.28665) (PMID:30613292) (PMCID:PMC6299693)

Cunningham, M. , McGonigal, R., Meehan, G. R. , Barrie, J. A., Yao, D., Halstead, S. K. and Willison, H. J. (2016) Anti-ganglioside antibodies are removed from circulation in mice by neuronal endocytosis. Brain, 139(6), pp. 1657-1665. (doi: 10.1093/brain/aww056) (PMID:27017187) (PMCID:PMC4892750)

Delmont, E., Robb, H., Davidson, A., Halstead, S., Yao, D., Meehan, G. R. and Willison, H. (2015) Prospective study comparing enzyme-linked immunosorbent assay and glycoarray assay to detect antiglycolipid antibodies in a routine diagnostic neuroimmunology laboratory setting. Clinical and Experimental Neuroimmunology, 6(2), pp. 175-182. (doi: 10.1111/cen3.12193)

Yao, D. et al. (2014) Neuronal expression of galnac transferase is sufficient to prevent the age-related neurodegenerative phenotype of complex ganglioside-deficient mice. Journal of Neuroscience, 34(3), pp. 880-891. (doi: 10.1523/JNEUROSCI.3996-13.2014)

Book Sections

Meehan, G. (2016) Glycolipids in GBS: from basic science to clinical interface. In: Willison, H. J. and Goodfellow, J. (eds.) GBS100: Celebrating a Century of Progress in Guillain-Barré Syndrome. Peripheral Nerve Society: San Diego, CA, pp. 327-333. ISBN 9780997510300

Conference or Workshop Item

Rupp, A., Yao, D., Meehan, G. R. and Willison, H. J. (2013) Thy-1 Mice Lend Themselves for the Modelling of Anti-ganglioside Antibody-mediated Disorders. PNS Biennial Meeting of the Peripheral Nerve Society, St Malo, France, 11-14 Jun 2013.

This list was generated on Mon Oct 19 01:08:52 2020 BST.