Dr Federica Giordani

  • Research Assistant (Parasitology)

telephone: 0141 330 5276
email: Federica.Giordani@glasgow.ac.uk

Biography

Dr. Federica Giordani is a post-doctoral researcher at the Wellcome Trust Centre for Molecular Parasitology in Glasgow. After a Master Degree in Biological Sciences/Genetics obtained at the University of Parma (Italy) in 2005, she kept working at the same institution as a researcher till 2007, focusing on assessment of the mutagenic risk of environmental matrices and of new anti-cancer and anti-parasitic leads. She then moved to the University of Glasgow, where she obtained her PhD in 2011, working on new fluorescence-based diagnostics for trypanosomiasis, supervised by Prof. Michael P. Barrett. As a research associate in the same lab, Dr. Giordani has continued working on drug discovery for trypanosomiasis and other neglected tropical diseases.


Research interests

Drug discovery for parasitic diseases (in particular for trypanosomiasis and leishmaniasis) is Dr. Giordani's main research interest. Working together with other academic institutions, non-profit organizations and private industry, she has contributed to several projects on this subject, gathering data on activity, mode of action and mechanisms of resistance of new leads. Her current project aims at establishing a long-term pipeline of new drugs to treat animal African trypanosomiasis, in collaboration with GALVmed. Management and control of communicable diseases, as well as their diagnosis, are all related themes of interest. 


Publications

List by: Type | Date

Jump to: 2018 | 2017 | 2016 | 2014
Number of items: 9.

2018

Steketee, P. C. et al. (2018) Benzoxaborole treatment perturbs S-adenosyl-L-methionine metabolism in Trypanosoma brucei. PLoS Neglected Tropical Diseases, 12(5), e0006450. (doi:10.1371/journal.pntd.0006450) (PMID:29758036) (PMCID:PMC5976210)

2017

Barrett, M. P. and Giordani, F. (2017) Inside Doctor Livingstone: a Scottish icon's encounter with tropical disease. Parasitology, 144(12), pp. 1652-1662. (doi:10.1017/S003118201600202X) (PMID:27928980)

Scott, F. J. et al. (2017) An evaluation of Minor Groove Binders as anti-fungal and anti-mycobacterial therapeutics. European Journal of Medicinal Chemistry, 136, pp. 561-572. (doi:10.1016/j.ejmech.2017.05.039)

2016

Giordani, F., Morrison, L. J., Rowan, T. G., De Koning, H. P. and Barrett, M. P. (2016) The animal trypanosomiases and their chemotherapy: a review. Parasitology, 143(14), pp. 1862-1889. (doi:10.1017/S0031182016001268) (PMID:27719692) (PMCID:PMC5142301)

Scott, F. J., Khalaf, A. I., Giordani, F., Wong, P. E., Duffy, S., Barrett, M. , Avery, V. M. and Suckling, C. J. (2016) An evaluation of Minor Groove Binders as anti-Trypanosoma brucei brucei therapeutics. European Journal of Medicinal Chemistry, 116, pp. 116-125. (doi:10.1016/j.ejmech.2016.03.064) (PMID:27060763) (PMCID:PMC4872591)

2014

Giordani, F., Buschini, A., Baliani, A., Kaiser, M., Brun, R., Barrett, M. P. , Pellacani, C., Poli, P. and Gilbert, I. H. (2014) Characterization of a melamino nitroheterocycle as a potential lead for the treatment of human African trypanosomiasis. Antimicrobial Agents and Chemotherapy, 58(10), pp. 5747-5757. (doi:10.1128/AAC.01449-13)

Giordani, F., Munde, M., Wilson, W. D., Ismail, M. A., Kumar, A., Boykin, D. W. and Barrett, M. P. (2014) Green fluorescent diamidines as diagnostic probes for trypanosomes. Antimicrobial Agents and Chemotherapy, 58(3), pp. 1793-1796. (doi:10.1128/AAC.02024-13)

Giordani, F., Mwenechanya, R. and Barrett, M. (2014) Advances in understanding and treatment of human African trypanosomiasis: divergent diseases caused by distinct parasites. In: Padmanabhan, S. (ed.) Handbook of Pharmacogenomics and Stratified Medicine. Academic Press, pp. 901-917. ISBN 9780123868824 (doi:10.1016/B978-0-12-386882-4.00039-6)

Khalaf, A. I., Huggan, J. K., Suckling, C. J., Gibson, C. L., Stewart, K., Giordani, F., Barrett, M. P. , Wong, P. E., Barrack, K. L. and Hunter, W. N. (2014) Structure-based design and synthesis of antiparasitic pyrrolopyrimidines targeting pteridine reductase 1. Journal of Medicinal Chemistry, 57(15), pp. 6479-6494. (doi:10.1021/jm500483b)

This list was generated on Thu Jul 19 19:17:22 2018 BST.
Number of items: 9.

Articles

Steketee, P. C. et al. (2018) Benzoxaborole treatment perturbs S-adenosyl-L-methionine metabolism in Trypanosoma brucei. PLoS Neglected Tropical Diseases, 12(5), e0006450. (doi:10.1371/journal.pntd.0006450) (PMID:29758036) (PMCID:PMC5976210)

Barrett, M. P. and Giordani, F. (2017) Inside Doctor Livingstone: a Scottish icon's encounter with tropical disease. Parasitology, 144(12), pp. 1652-1662. (doi:10.1017/S003118201600202X) (PMID:27928980)

Scott, F. J. et al. (2017) An evaluation of Minor Groove Binders as anti-fungal and anti-mycobacterial therapeutics. European Journal of Medicinal Chemistry, 136, pp. 561-572. (doi:10.1016/j.ejmech.2017.05.039)

Giordani, F., Morrison, L. J., Rowan, T. G., De Koning, H. P. and Barrett, M. P. (2016) The animal trypanosomiases and their chemotherapy: a review. Parasitology, 143(14), pp. 1862-1889. (doi:10.1017/S0031182016001268) (PMID:27719692) (PMCID:PMC5142301)

Scott, F. J., Khalaf, A. I., Giordani, F., Wong, P. E., Duffy, S., Barrett, M. , Avery, V. M. and Suckling, C. J. (2016) An evaluation of Minor Groove Binders as anti-Trypanosoma brucei brucei therapeutics. European Journal of Medicinal Chemistry, 116, pp. 116-125. (doi:10.1016/j.ejmech.2016.03.064) (PMID:27060763) (PMCID:PMC4872591)

Giordani, F., Buschini, A., Baliani, A., Kaiser, M., Brun, R., Barrett, M. P. , Pellacani, C., Poli, P. and Gilbert, I. H. (2014) Characterization of a melamino nitroheterocycle as a potential lead for the treatment of human African trypanosomiasis. Antimicrobial Agents and Chemotherapy, 58(10), pp. 5747-5757. (doi:10.1128/AAC.01449-13)

Giordani, F., Munde, M., Wilson, W. D., Ismail, M. A., Kumar, A., Boykin, D. W. and Barrett, M. P. (2014) Green fluorescent diamidines as diagnostic probes for trypanosomes. Antimicrobial Agents and Chemotherapy, 58(3), pp. 1793-1796. (doi:10.1128/AAC.02024-13)

Khalaf, A. I., Huggan, J. K., Suckling, C. J., Gibson, C. L., Stewart, K., Giordani, F., Barrett, M. P. , Wong, P. E., Barrack, K. L. and Hunter, W. N. (2014) Structure-based design and synthesis of antiparasitic pyrrolopyrimidines targeting pteridine reductase 1. Journal of Medicinal Chemistry, 57(15), pp. 6479-6494. (doi:10.1021/jm500483b)

Book Sections

Giordani, F., Mwenechanya, R. and Barrett, M. (2014) Advances in understanding and treatment of human African trypanosomiasis: divergent diseases caused by distinct parasites. In: Padmanabhan, S. (ed.) Handbook of Pharmacogenomics and Stratified Medicine. Academic Press, pp. 901-917. ISBN 9780123868824 (doi:10.1016/B978-0-12-386882-4.00039-6)

This list was generated on Thu Jul 19 19:17:22 2018 BST.