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telephone:
01413304019
email:
Derek.Wright@glasgow.ac.uk
Institute of Cancer Sciences, Wolfson Wohl Cancer Research Centre, Garscube Estate, Switchback Road, Bearsden, Glasgow, G61 1QH
Bioinformatics, computational biology, data science.
Meehan, G. R. et al. (2023) Phenotyping the virulence of SARS-CoV-2 variants in hamsters by digital pathology and machine learning. PLoS Pathogens, 19(11), e1011589. (doi: 10.1371/journal.ppat.1011589) (PMID:37934791) (PMCID:PMC10656012)
Cox, M. et al. (2023) SARS-CoV-2 variant evasion of monoclonal antibodies based on in vitro studies. Nature Reviews Microbiology, 21(2), pp. 112-124. (doi: 10.1038/s41579-022-00809-7) (PMID:36307535) (PMCID:PMC9616429)
Wright, D. W. et al. (2022) Tracking SARS-CoV-2 mutations and variants through the COG-UK-Mutation Explorer. Virus Evolution, 8(1), veac023. (doi: 10.1093/ve/veac023) (PMID:35502202) (PMCID:PMC9037374)
Vöhringer, H. S. et al. (2021) Genomic reconstruction of the SARS-CoV-2 epidemic in England. Nature, 600(7889), pp. 506-511. (doi: 10.1038/s41586-021-04069-y) (PMID:34649268) (PMCID:PMC8674138)
Dreyer, S. B. et al. (2021) Targeting DNA damage response and replication stress in pancreatic cancer. Gastroenterology, 160(1), pp. 362-377. (doi: 10.1053/j.gastro.2020.09.043) (PMID:33039466) (PMCID:PMC8167930)
Bailey, M. H. et al. (2020) Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples. Nature Communications, 11, 4748. (doi: 10.1038/s41467-020-18151-y) (PMID:32958763) (PMCID:PMC7505971)
Li, C. H. et al. (2020) Sex differences in oncogenic mutational processes. Nature Communications, 11, 4330. (doi: 10.1038/s41467-020-17359-2) (PMID:32859912) (PMCID:PMC7455744)
Brunton, H. et al. (2020) HNF4A and GATA6 loss reveals therapeutically actionable subtypes in pancreatic cancer. Cell Reports, 31(6), 107625. (doi: 10.1016/j.celrep.2020.107625) (PMID:32402285)
The ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium, et al. (2020) Pan-cancer analysis of whole genomes. Nature, 578(7793), pp. 82-93. (doi: 10.1038/s41586-020-1969-6) (PMID:32025007) (PMCID:PMC7025898)
Jiao, W. et al. (2020) A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns. Nature Communications, 11, 728. (doi: 10.1038/s41467-019-13825-8) (PMID:32024849) (PMCID:PMC7002586)
Livigni, A., O'Hara, L., Polak, M. E., Angus, T., Wright, D. W. , Smith, L. B. and Freeman, T. C. (2018) A graphical and computational modeling platform for biological pathways. Nature Protocols, 13(4), pp. 705-722. (doi: 10.1038/nprot.2017.144) (PMID:29543794)
O’Hara, L. et al. (2016) Modelling the structure and dynamics of biological pathways. PLoS Biology, 14(8), e1002530. (doi: 10.1371/journal.pbio.1002530) (PMID:27509052) (PMCID:PMC4980033)
Lizio, M. et al. (2015) Gateways to the FANTOM5 promoter level mammalian expression atlas. Genome Biology, 16, 22. (doi: 10.1186/s13059-014-0560-6) (PMID:25723102) (PMCID:PMC4310165)
Wright, D. W. , Angus, T., Enright, A. J. and Freeman, T. C. (2014) Visualisation of BioPAX Networks using BioLayout Express3D. F1000Research, 3, 246. (doi: 10.12688/f1000research.5499.1) (PMID:25949802) (PMCID:PMC4406191)
Evans, M. C.W., Purton, S., Patel, V., Wright, D. , Heathcote, P. and Rigby, S. E.J. (1999) Modification of electron transfer from the quinone electron carrier, A(1), of Photosystem 1 in a site directed mutant D576 double right arrow L within the Fe-S(x) binding site of PsaA and in second site suppressors of the mutation in Chlamydomonas reinhardtii. Photosynthesis Research, 61(1), pp. 33-42. (doi: 10.1023/A:1006205811407)
Hallahan, B. J., Purton, S., Ivison, A., Wright, D. and Evans, M. C. W. (1995) Analysis of the proposed Fe-SX binding region of Photosystem 1 by site directed mutation of PsaA in Chlamydomonas reinhardtii. Photosynthesis Research, 46(1-2), pp. 257-264. (doi: 10.1007/BF00020438) (PMID:24301590)
Meehan, G. R. et al. (2023) Phenotyping the virulence of SARS-CoV-2 variants in hamsters by digital pathology and machine learning. PLoS Pathogens, 19(11), e1011589. (doi: 10.1371/journal.ppat.1011589) (PMID:37934791) (PMCID:PMC10656012)
Cox, M. et al. (2023) SARS-CoV-2 variant evasion of monoclonal antibodies based on in vitro studies. Nature Reviews Microbiology, 21(2), pp. 112-124. (doi: 10.1038/s41579-022-00809-7) (PMID:36307535) (PMCID:PMC9616429)
Wright, D. W. et al. (2022) Tracking SARS-CoV-2 mutations and variants through the COG-UK-Mutation Explorer. Virus Evolution, 8(1), veac023. (doi: 10.1093/ve/veac023) (PMID:35502202) (PMCID:PMC9037374)
Vöhringer, H. S. et al. (2021) Genomic reconstruction of the SARS-CoV-2 epidemic in England. Nature, 600(7889), pp. 506-511. (doi: 10.1038/s41586-021-04069-y) (PMID:34649268) (PMCID:PMC8674138)
Dreyer, S. B. et al. (2021) Targeting DNA damage response and replication stress in pancreatic cancer. Gastroenterology, 160(1), pp. 362-377. (doi: 10.1053/j.gastro.2020.09.043) (PMID:33039466) (PMCID:PMC8167930)
Bailey, M. H. et al. (2020) Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples. Nature Communications, 11, 4748. (doi: 10.1038/s41467-020-18151-y) (PMID:32958763) (PMCID:PMC7505971)
Li, C. H. et al. (2020) Sex differences in oncogenic mutational processes. Nature Communications, 11, 4330. (doi: 10.1038/s41467-020-17359-2) (PMID:32859912) (PMCID:PMC7455744)
Brunton, H. et al. (2020) HNF4A and GATA6 loss reveals therapeutically actionable subtypes in pancreatic cancer. Cell Reports, 31(6), 107625. (doi: 10.1016/j.celrep.2020.107625) (PMID:32402285)
The ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium, et al. (2020) Pan-cancer analysis of whole genomes. Nature, 578(7793), pp. 82-93. (doi: 10.1038/s41586-020-1969-6) (PMID:32025007) (PMCID:PMC7025898)
Jiao, W. et al. (2020) A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns. Nature Communications, 11, 728. (doi: 10.1038/s41467-019-13825-8) (PMID:32024849) (PMCID:PMC7002586)
Livigni, A., O'Hara, L., Polak, M. E., Angus, T., Wright, D. W. , Smith, L. B. and Freeman, T. C. (2018) A graphical and computational modeling platform for biological pathways. Nature Protocols, 13(4), pp. 705-722. (doi: 10.1038/nprot.2017.144) (PMID:29543794)
O’Hara, L. et al. (2016) Modelling the structure and dynamics of biological pathways. PLoS Biology, 14(8), e1002530. (doi: 10.1371/journal.pbio.1002530) (PMID:27509052) (PMCID:PMC4980033)
Lizio, M. et al. (2015) Gateways to the FANTOM5 promoter level mammalian expression atlas. Genome Biology, 16, 22. (doi: 10.1186/s13059-014-0560-6) (PMID:25723102) (PMCID:PMC4310165)
Wright, D. W. , Angus, T., Enright, A. J. and Freeman, T. C. (2014) Visualisation of BioPAX Networks using BioLayout Express3D. F1000Research, 3, 246. (doi: 10.12688/f1000research.5499.1) (PMID:25949802) (PMCID:PMC4406191)
Evans, M. C.W., Purton, S., Patel, V., Wright, D. , Heathcote, P. and Rigby, S. E.J. (1999) Modification of electron transfer from the quinone electron carrier, A(1), of Photosystem 1 in a site directed mutant D576 double right arrow L within the Fe-S(x) binding site of PsaA and in second site suppressors of the mutation in Chlamydomonas reinhardtii. Photosynthesis Research, 61(1), pp. 33-42. (doi: 10.1023/A:1006205811407)
Hallahan, B. J., Purton, S., Ivison, A., Wright, D. and Evans, M. C. W. (1995) Analysis of the proposed Fe-SX binding region of Photosystem 1 by site directed mutation of PsaA in Chlamydomonas reinhardtii. Photosynthesis Research, 46(1-2), pp. 257-264. (doi: 10.1007/BF00020438) (PMID:24301590)
Meehan, G. , Herder, V. , Allan, J., Huang, X., Kerr, K., Correa Mendonca, D. , Ilia, G., Wright, D. , Nomikou, K., Gu, Q. , Molina Arias, S., Hansmann, F., Hardas, A., Attipa, C., De Lorenzo, G. , Cowton, V., Upfold, N. , Palmalux, N., Brown, J., Barclay, W., Da Silva Filipe, A. , Furnon, W. , Patel, A. and Palmarini, M. (2023) Phenotyping the virulence of SARS-CoV-2 variants in hamsters by digital pathology and machine learning. [Data Collection]
https://orcid.org/0000-0003-0411-4497